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Chemical modifications of peptides introduced strategically at potential enzymatic cleavage sites may dramatically increase the in vivo stability of peptide drug candidates. One simple approach to stabilizing a peptide is to modify the side-chains of some of the amino acids involved in the protease recognition site. The residues of interest are replaced by natural or non-natural amino acids with chemically similar side-chains. The introduction of non-natural amino acids generates modifications in the secondary and tertiary structures of a peptide, and is used to further enhance the stability and activity of peptide sequences. More at www.creative-peptides.com/services/unusual-and-non-natura...

"Slight modifications required" to fit all of my wiring into my car lol

Architecture, also modifications

Automatic focus, guider scope and dotfinder.

Added retention straps for the ARB fridge and an access panel for the storage area that fomerly housed a donut.

ETA-6497 hand-wind, Sapphire Crystal

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Goss performs a song on the piano on November 12, 2017. Colored stickers are placed on different keys for his convenience. Because of his disability, it is challenging for Goss to comprehend certain things, such as learning musical notes. A great way to make accommodate for cognitive impairment is to use colors instead of letters. In this case, Goss is able to memorize colors to perform a song instead of the classic letter scales.

Modification of Firas Abu-Jaber 10295 Alternate build.

This image is FREE for modification, publication, and other use under a Creative Commons attribution license. Suggested credit: “by Dan Wahl, dontdoubtyourhorses.com”

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The self-determined 400 Horses Project required that I create 400 horse drawings in one year while learning to like every horse. The liking part was especially challenging.

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This evolved into Don't Doubt Your Horses, a participatory art project that encourages you to unharness your creative spirit ​by making horses.

For these images I tried to take a landscape type shot by putting 400 ISO 35mm film into a Holga 120 camera. These shots were taken in Athens, OH. I took these shots based on the predominant colors of yellow and green that I saw while capturing this image, although they aren't conveyed as well as I would have hoped. The main problem I had with this process was that I didn't take into consideration how much more cropped these images would be by using the 35mm film, thus the top portion of the image I believed I was taking is sliced off.

I almost forgot to do the big pieces first

Compact Camera Hardware Glitch

this is the backside of the unit. it is also clear and as you can see it has 2 switches and 6 lights. when the first is on, the leds go into sound reactive mode and are wired to the internal speakers. when music is played, the brightness increases with sound up to 75% brightness and when no sound is played, the lights are as well. the lights flash perfect with no delay and is very smooth. when both switches are active, it enables the light feature and the lights all go tofull power. it is VERY bright and shouldnt be directly looked at...

Beginnings of genetically modified corn costume for Josie

With the catch-pin removed, the forward portion of the block can slide forward, releasing the rollers. After dropping the new rollers into place, the process is simply reversed, and the pin hammered back into place to secure them.

The Impossible Waistline.

Mixed Media Illustration. Pencil & Photography Collage.

Charlotte Josephine 2013.

Building a tool.

 

This is an inexpensive disposable film camera modified to fire the flash when a momentary contact button mounted on the scrap wood is pressed.

Step 6: Remove 3 screws from the back of the turret that were uncovered by the removal of the advancing mechanism.

Before modification

Architecture, also modifications

I had an old Toshiba Satellite Pro 420CDS, a DLINK Wireless Router, and a Lockergnome mousepad laying around...here's what happened.

Compact Camera Hardware Glitch

Sirion/YRV anti roll bar need to bend narrower to fit Cuore lower arm. Please check the red circle for burn mark after heat bending process.

1 human leg + 1 human leg + one kitty leg photobombing what was admittedly not a great photo to begin with.

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