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Modifications and upgrades are underway inside the Astronaut Crew Quarters in the Neil Armstrong Operations and Checkout Building at NASA's Kennedy Space Center in Florida. New carpeting and trim has been installed along a hallway and into some of the bedrooms. Photos of astronauts' families line the walls. The crew quarters are being prepared for the next generation of space explorers. The historic facility housed Apollo and space shuttle astronauts before and after their missions into space. Photo credit: NASA/Kim Shiflett
Rohloff wheel build, custom double split stops for roholoff cable routing, new swingarm bushing, cut out old CS and SS bridges, respace to 135 (was 120 with a 2 speed kickback and a Schlumpf), install new bridges, rear canti posts, cable stops for rear brake, various cable guides, fender install, run all new cables and housing with cable splitters, rewrap bars.
The "Pecking Mechanism" is my modifications of the "Pecking Kingfisher" by Yamada Katsuhisa.
A double-sided heart is attached to the "Pecking Mechanism" to form the "Heartbeat" model. See the video clip here - www.flickr.com/photos/61236172@N08/14230223695/
Other simple models can also be attached to the "Pecking Mechanism". Try to make your own model and attach it to the "Pecking Mechanism". You may want to "cheat" by using glue but try to do it without glue.
Another Matchbox Series No4 Dodge K Series Stake Bed Truck Modification. 1966 to 1968 - 1-75 Series. This is the testing with the new color and the restored stake bed painted green. The color I like but on the truck but I am not happy with the stake bed. The warp is bad and I tried to fix it without it breaking which it wanted to do. I even soaked it in hot water to soften it but not luck.
the drawn on plan for my friend's tattoo that she's getting next month :)
excuse the poor quality, it was taken with my phone
now that my subscritpion has expired see all of my art here www.flickr.com/groups/463498@N21/
Colosseum
Following, a text, in english, from the Wikipedia the Free Encyclopedia:
The Colosseum, or the Coliseum, originally the Flavian Amphitheatre (Latin: Amphitheatrum Flavium, Italian Anfiteatro Flavio or Colosseo), is an elliptical amphitheatre in the centre of the city of Rome, Italy, the largest ever built in the Roman Empire. It is considered one of the greatest works of Roman architecture and Roman engineering.
Occupying a site just east of the Roman Forum, its construction started between 70 and 72 AD[1] under the emperor Vespasian and was completed in 80 AD under Titus,[2] with further modifications being made during Domitian's reign (81–96).[3] The name "Amphitheatrum Flavium" derives from both Vespasian's and Titus's family name (Flavius, from the gens Flavia).
Capable of seating 50,000 spectators,[1][4][5] the Colosseum was used for gladiatorial contests and public spectacles such as mock sea battles, animal hunts, executions, re-enactments of famous battles, and dramas based on Classical mythology. The building ceased to be used for entertainment in the early medieval era. It was later reused for such purposes as housing, workshops, quarters for a religious order, a fortress, a quarry, and a Christian shrine.
Although in the 21st century it stays partially ruined because of damage caused by devastating earthquakes and stone-robbers, the Colosseum is an iconic symbol of Imperial Rome. It is one of Rome's most popular tourist attractions and still has close connections with the Roman Catholic Church, as each Good Friday the Pope leads a torchlit "Way of the Cross" procession that starts in the area around the Colosseum.[6]
The Colosseum is also depicted on the Italian version of the five-cent euro coin.
The Colosseum's original Latin name was Amphitheatrum Flavium, often anglicized as Flavian Amphitheater. The building was constructed by emperors of the Flavian dynasty, hence its original name, after the reign of Emperor Nero.[7] This name is still used in modern English, but generally the structure is better known as the Colosseum. In antiquity, Romans may have referred to the Colosseum by the unofficial name Amphitheatrum Caesareum; this name could have been strictly poetic.[8][9] This name was not exclusive to the Colosseum; Vespasian and Titus, builders of the Colosseum, also constructed an amphitheater of the same name in Puteoli (modern Pozzuoli).[10]
The name Colosseum has long been believed to be derived from a colossal statue of Nero nearby.[3] (the statue of Nero itself being named after one of the original ancient wonders, the Colossus of Rhodes[citation needed]. This statue was later remodeled by Nero's successors into the likeness of Helios (Sol) or Apollo, the sun god, by adding the appropriate solar crown. Nero's head was also replaced several times with the heads of succeeding emperors. Despite its pagan links, the statue remained standing well into the medieval era and was credited with magical powers. It came to be seen as an iconic symbol of the permanence of Rome.
In the 8th century, a famous epigram attributed to the Venerable Bede celebrated the symbolic significance of the statue in a prophecy that is variously quoted: Quamdiu stat Colisæus, stat et Roma; quando cadet colisæus, cadet et Roma; quando cadet Roma, cadet et mundus ("as long as the Colossus stands, so shall Rome; when the Colossus falls, Rome shall fall; when Rome falls, so falls the world").[11] This is often mistranslated to refer to the Colosseum rather than the Colossus (as in, for instance, Byron's poem Childe Harold's Pilgrimage). However, at the time that the Pseudo-Bede wrote, the masculine noun coliseus was applied to the statue rather than to what was still known as the Flavian amphitheatre.
The Colossus did eventually fall, possibly being pulled down to reuse its bronze. By the year 1000 the name "Colosseum" had been coined to refer to the amphitheatre. The statue itself was largely forgotten and only its base survives, situated between the Colosseum and the nearby Temple of Venus and Roma.[12]
The name further evolved to Coliseum during the Middle Ages. In Italy, the amphitheatre is still known as il Colosseo, and other Romance languages have come to use similar forms such as le Colisée (French), el Coliseo (Spanish) and o Coliseu (Portuguese).
Construction of the Colosseum began under the rule of the Emperor Vespasian[3] in around 70–72AD. The site chosen was a flat area on the floor of a low valley between the Caelian, Esquiline and Palatine Hills, through which a canalised stream ran. By the 2nd century BC the area was densely inhabited. It was devastated by the Great Fire of Rome in AD 64, following which Nero seized much of the area to add to his personal domain. He built the grandiose Domus Aurea on the site, in front of which he created an artificial lake surrounded by pavilions, gardens and porticoes. The existing Aqua Claudia aqueduct was extended to supply water to the area and the gigantic bronze Colossus of Nero was set up nearby at the entrance to the Domus Aurea.[12]
Although the Colossus was preserved, much of the Domus Aurea was torn down. The lake was filled in and the land reused as the location for the new Flavian Amphitheatre. Gladiatorial schools and other support buildings were constructed nearby within the former grounds of the Domus Aurea. According to a reconstructed inscription found on the site, "the emperor Vespasian ordered this new amphitheatre to be erected from his general's share of the booty." This is thought to refer to the vast quantity of treasure seized by the Romans following their victory in the Great Jewish Revolt in 70AD. The Colosseum can be thus interpreted as a great triumphal monument built in the Roman tradition of celebrating great victories[12], placating the Roman people instead of returning soldiers. Vespasian's decision to build the Colosseum on the site of Nero's lake can also be seen as a populist gesture of returning to the people an area of the city which Nero had appropriated for his own use. In contrast to many other amphitheatres, which were located on the outskirts of a city, the Colosseum was constructed in the city centre; in effect, placing it both literally and symbolically at the heart of Rome.
The Colosseum had been completed up to the third story by the time of Vespasian's death in 79. The top level was finished and the building inaugurated by his son, Titus, in 80.[3] Dio Cassius recounts that over 9,000 wild animals were killed during the inaugural games of the amphitheatre. The building was remodelled further under Vespasian's younger son, the newly designated Emperor Domitian, who constructed the hypogeum, a series of underground tunnels used to house animals and slaves. He also added a gallery to the top of the Colosseum to increase its seating capacity.
In 217, the Colosseum was badly damaged by a major fire (caused by lightning, according to Dio Cassius[13]) which destroyed the wooden upper levels of the amphitheatre's interior. It was not fully repaired until about 240 and underwent further repairs in 250 or 252 and again in 320. An inscription records the restoration of various parts of the Colosseum under Theodosius II and Valentinian III (reigned 425–455), possibly to repair damage caused by a major earthquake in 443; more work followed in 484[14] and 508. The arena continued to be used for contests well into the 6th century, with gladiatorial fights last mentioned around 435. Animal hunts continued until at least 523, when Anicius Maximus celebrated his consulship with some venationes, criticised by King Theodoric the Great for their high cost.
The Colosseum underwent several radical changes of use during the medieval period. By the late 6th century a small church had been built into the structure of the amphitheatre, though this apparently did not confer any particular religious significance on the building as a whole. The arena was converted into a cemetery. The numerous vaulted spaces in the arcades under the seating were converted into housing and workshops, and are recorded as still being rented out as late as the 12th century. Around 1200 the Frangipani family took over the Colosseum and fortified it, apparently using it as a castle.
Severe damage was inflicted on the Colosseum by the great earthquake in 1349, causing the outer south side, lying on a less stable alluvional terrain, to collapse. Much of the tumbled stone was reused to build palaces, churches, hospitals and other buildings elsewhere in Rome. A religious order moved into the northern third of the Colosseum in the mid-14th century and continued to inhabit it until as late as the early 19th century. The interior of the amphitheatre was extensively stripped of stone, which was reused elsewhere, or (in the case of the marble façade) was burned to make quicklime.[12] The bronze clamps which held the stonework together were pried or hacked out of the walls, leaving numerous pockmarks which still scar the building today.
During the 16th and 17th century, Church officials sought a productive role for the vast derelict hulk of the Colosseum. Pope Sixtus V (1585–1590) planned to turn the building into a wool factory to provide employment for Rome's prostitutes, though this proposal fell through with his premature death.[15] In 1671 Cardinal Altieri authorized its use for bullfights; a public outcry caused the idea to be hastily abandoned.
In 1749, Pope Benedict XIV endorsed as official Church policy the view that the Colosseum was a sacred site where early Christians had been martyred. He forbade the use of the Colosseum as a quarry and consecrated the building to the Passion of Christ and installed Stations of the Cross, declaring it sanctified by the blood of the Christian martyrs who perished there (see Christians and the Colosseum). However there is no historical evidence to support Benedict's claim, nor is there even any evidence that anyone prior to the 16th century suggested this might be the case; the Catholic Encyclopedia concludes that there are no historical grounds for the supposition. Later popes initiated various stabilization and restoration projects, removing the extensive vegetation which had overgrown the structure and threatened to damage it further. The façade was reinforced with triangular brick wedges in 1807 and 1827, and the interior was repaired in 1831, 1846 and in the 1930s. The arena substructure was partly excavated in 1810–1814 and 1874 and was fully exposed under Benito Mussolini in the 1930s.
The Colosseum is today one of Rome's most popular tourist attractions, receiving millions of visitors annually. The effects of pollution and general deterioration over time prompted a major restoration programme carried out between 1993 and 2000, at a cost of 40 billion Italian lire ($19.3m / €20.6m at 2000 prices). In recent years it has become a symbol of the international campaign against capital punishment, which was abolished in Italy in 1948. Several anti–death penalty demonstrations took place in front of the Colosseum in 2000. Since that time, as a gesture against the death penalty, the local authorities of Rome change the color of the Colosseum's night time illumination from white to gold whenever a person condemned to the death penalty anywhere in the world gets their sentence commuted or is released,[16] or if a jurisdiction abolishes the death penalty. Most recently, the Colosseum was illuminated in gold when capital punishment was abolished in the American state of New Mexico in April 2009.
Because of the ruined state of the interior, it is impractical to use the Colosseum to host large events; only a few hundred spectators can be accommodated in temporary seating. However, much larger concerts have been held just outside, using the Colosseum as a backdrop. Performers who have played at the Colosseum in recent years have included Ray Charles (May 2002),[18] Paul McCartney (May 2003),[19] Elton John (September 2005),[20] and Billy Joel (July 2006).
Exterior
Unlike earlier Greek theatres that were built into hillsides, the Colosseum is an entirely free-standing structure. It derives its basic exterior and interior architecture from that of two Roman theatres back to back. It is elliptical in plan and is 189 meters (615 ft / 640 Roman feet) long, and 156 meters (510 ft / 528 Roman feet) wide, with a base area of 6 acres (24,000 m2). The height of the outer wall is 48 meters (157 ft / 165 Roman feet). The perimeter originally measured 545 meters (1,788 ft / 1,835 Roman feet). The central arena is an oval 87 m (287 ft) long and 55 m (180 ft) wide, surrounded by a wall 5 m (15 ft) high, above which rose tiers of seating.
The outer wall is estimated to have required over 100,000 cubic meters (131,000 cu yd) of travertine stone which were set without mortar held together by 300 tons of iron clamps.[12] However, it has suffered extensive damage over the centuries, with large segments having collapsed following earthquakes. The north side of the perimeter wall is still standing; the distinctive triangular brick wedges at each end are modern additions, having been constructed in the early 19th century to shore up the wall. The remainder of the present-day exterior of the Colosseum is in fact the original interior wall.
The surviving part of the outer wall's monumental façade comprises three stories of superimposed arcades surmounted by a podium on which stands a tall attic, both of which are pierced by windows interspersed at regular intervals. The arcades are framed by half-columns of the Tuscan, Ionic, and Corinthian orders, while the attic is decorated with Corinthian pilasters.[21] Each of the arches in the second- and third-floor arcades framed statues, probably honoring divinities and other figures from Classical mythology.
Two hundred and forty mast corbels were positioned around the top of the attic. They originally supported a retractable awning, known as the velarium, that kept the sun and rain off spectators. This consisted of a canvas-covered, net-like structure made of ropes, with a hole in the center.[3] It covered two-thirds of the arena, and sloped down towards the center to catch the wind and provide a breeze for the audience. Sailors, specially enlisted from the Roman naval headquarters at Misenum and housed in the nearby Castra Misenatium, were used to work the velarium.[22]
The Colosseum's huge crowd capacity made it essential that the venue could be filled or evacuated quickly. Its architects adopted solutions very similar to those used in modern stadiums to deal with the same problem. The amphitheatre was ringed by eighty entrances at ground level, 76 of which were used by ordinary spectators.[3] Each entrance and exit was numbered, as was each staircase. The northern main entrance was reserved for the Roman Emperor and his aides, whilst the other three axial entrances were most likely used by the elite. All four axial entrances were richly decorated with painted stucco reliefs, of which fragments survive. Many of the original outer entrances have disappeared with the collapse of the perimeter wall, but entrances XXIII (23) to LIV (54) still survive.[12]
Spectators were given tickets in the form of numbered pottery shards, which directed them to the appropriate section and row. They accessed their seats via vomitoria (singular vomitorium), passageways that opened into a tier of seats from below or behind. These quickly dispersed people into their seats and, upon conclusion of the event or in an emergency evacuation, could permit their exit within only a few minutes. The name vomitoria derived from the Latin word for a rapid discharge, from which English derives the word vomit.
Interior
According to the Codex-Calendar of 354, the Colosseum could accommodate 87,000 people, although modern estimates put the figure at around 50,000. They were seated in a tiered arrangement that reflected the rigidly stratified nature of Roman society. Special boxes were provided at the north and south ends respectively for the Emperor and the Vestal Virgins, providing the best views of the arena. Flanking them at the same level was a broad platform or podium for the senatorial class, who were allowed to bring their own chairs. The names of some 5th century senators can still be seen carved into the stonework, presumably reserving areas for their use.
The tier above the senators, known as the maenianum primum, was occupied by the non-senatorial noble class or knights (equites). The next level up, the maenianum secundum, was originally reserved for ordinary Roman citizens (plebians) and was divided into two sections. The lower part (the immum) was for wealthy citizens, while the upper part (the summum) was for poor citizens. Specific sectors were provided for other social groups: for instance, boys with their tutors, soldiers on leave, foreign dignitaries, scribes, heralds, priests and so on. Stone (and later marble) seating was provided for the citizens and nobles, who presumably would have brought their own cushions with them. Inscriptions identified the areas reserved for specific groups.
Another level, the maenianum secundum in legneis, was added at the very top of the building during the reign of Domitian. This comprised a gallery for the common poor, slaves and women. It would have been either standing room only, or would have had very steep wooden benches. Some groups were banned altogether from the Colosseum, notably gravediggers, actors and former gladiators.
Each tier was divided into sections (maeniana) by curved passages and low walls (praecinctiones or baltei), and were subdivided into cunei, or wedges, by the steps and aisles from the vomitoria. Each row (gradus) of seats was numbered, permitting each individual seat to be exactly designated by its gradus, cuneus, and number.
The arena itself was 83 meters by 48 meters (272 ft by 157 ft / 280 by 163 Roman feet).[12] It comprised a wooden floor covered by sand (the Latin word for sand is harena or arena), covering an elaborate underground structure called the hypogeum (literally meaning "underground"). Little now remains of the original arena floor, but the hypogeum is still clearly visible. It consisted of a two-level subterranean network of tunnels and cages beneath the arena where gladiators and animals were held before contests began. Eighty vertical shafts provided instant access to the arena for caged animals and scenery pieces concealed underneath; larger hinged platforms, called hegmata, provided access for elephants and the like. It was restructured on numerous occasions; at least twelve different phases of construction can be seen.[12]
The hypogeum was connected by underground tunnels to a number of points outside the Colosseum. Animals and performers were brought through the tunnel from nearby stables, with the gladiators' barracks at the Ludus Magnus to the east also being connected by tunnels. Separate tunnels were provided for the Emperor and the Vestal Virgins to permit them to enter and exit the Colosseum without needing to pass through the crowds.[12]
Substantial quantities of machinery also existed in the hypogeum. Elevators and pulleys raised and lowered scenery and props, as well as lifting caged animals to the surface for release. There is evidence for the existence of major hydraulic mechanisms[12] and according to ancient accounts, it was possible to flood the arena rapidly, presumably via a connection to a nearby aqueduct.
The Colosseum and its activities supported a substantial industry in the area. In addition to the amphitheatre itself, many other buildings nearby were linked to the games. Immediately to the east is the remains of the Ludus Magnus, a training school for gladiators. This was connected to the Colosseum by an underground passage, to allow easy access for the gladiators. The Ludus Magnus had its own miniature training arena, which was itself a popular attraction for Roman spectators. Other training schools were in the same area, including the Ludus Matutinus (Morning School), where fighters of animals were trained, plus the Dacian and Gallic Schools.
Also nearby were the Armamentarium, comprising an armory to store weapons; the Summum Choragium, where machinery was stored; the Sanitarium, which had facilities to treat wounded gladiators; and the Spoliarium, where bodies of dead gladiators were stripped of their armor and disposed of.
Around the perimeter of the Colosseum, at a distance of 18 m (59 ft) from the perimeter, was a series of tall stone posts, with five remaining on the eastern side. Various explanations have been advanced for their presence; they may have been a religious boundary, or an outer boundary for ticket checks, or an anchor for the velarium or awning.
Right next to the Colosseum is also the Arch of Constantine.
he Colosseum was used to host gladiatorial shows as well as a variety of other events. The shows, called munera, were always given by private individuals rather than the state. They had a strong religious element but were also demonstrations of power and family prestige, and were immensely popular with the population. Another popular type of show was the animal hunt, or venatio. This utilized a great variety of wild beasts, mainly imported from Africa and the Middle East, and included creatures such as rhinoceros, hippopotamuses, elephants, giraffes, aurochs, wisents, barbary lions, panthers, leopards, bears, caspian tigers, crocodiles and ostriches. Battles and hunts were often staged amid elaborate sets with movable trees and buildings. Such events were occasionally on a huge scale; Trajan is said to have celebrated his victories in Dacia in 107 with contests involving 11,000 animals and 10,000 gladiators over the course of 123 days.
During the early days of the Colosseum, ancient writers recorded that the building was used for naumachiae (more properly known as navalia proelia) or simulated sea battles. Accounts of the inaugural games held by Titus in AD 80 describe it being filled with water for a display of specially trained swimming horses and bulls. There is also an account of a re-enactment of a famous sea battle between the Corcyrean (Corfiot) Greeks and the Corinthians. This has been the subject of some debate among historians; although providing the water would not have been a problem, it is unclear how the arena could have been waterproofed, nor would there have been enough space in the arena for the warships to move around. It has been suggested that the reports either have the location wrong, or that the Colosseum originally featured a wide floodable channel down its central axis (which would later have been replaced by the hypogeum).[12]
Sylvae or recreations of natural scenes were also held in the arena. Painters, technicians and architects would construct a simulation of a forest with real trees and bushes planted in the arena's floor. Animals would be introduced to populate the scene for the delight of the crowd. Such scenes might be used simply to display a natural environment for the urban population, or could otherwise be used as the backdrop for hunts or dramas depicting episodes from mythology. They were also occasionally used for executions in which the hero of the story — played by a condemned person — was killed in one of various gruesome but mythologically authentic ways, such as being mauled by beasts or burned to death.
The Colosseum today is now a major tourist attraction in Rome with thousands of tourists each year paying to view the interior arena, though entrance for EU citizens is partially subsidised, and under-18 and over-65 EU citizens' entrances are free.[24] There is now a museum dedicated to Eros located in the upper floor of the outer wall of the building. Part of the arena floor has been re-floored. Beneath the Colosseum, a network of subterranean passageways once used to transport wild animals and gladiators to the arena opened to the public in summer 2010.[25]
The Colosseum is also the site of Roman Catholic ceremonies in the 20th and 21st centuries. For instance, Pope Benedict XVI leads the Stations of the Cross called the Scriptural Way of the Cross (which calls for more meditation) at the Colosseum[26][27] on Good Fridays.
In the Middle Ages, the Colosseum was clearly not regarded as a sacred site. Its use as a fortress and then a quarry demonstrates how little spiritual importance was attached to it, at a time when sites associated with martyrs were highly venerated. It was not included in the itineraries compiled for the use of pilgrims nor in works such as the 12th century Mirabilia Urbis Romae ("Marvels of the City of Rome"), which claims the Circus Flaminius — but not the Colosseum — as the site of martyrdoms. Part of the structure was inhabited by a Christian order, but apparently not for any particular religious reason.
It appears to have been only in the 16th and 17th centuries that the Colosseum came to be regarded as a Christian site. Pope Pius V (1566–1572) is said to have recommended that pilgrims gather sand from the arena of the Colosseum to serve as a relic, on the grounds that it was impregnated with the blood of martyrs. This seems to have been a minority view until it was popularised nearly a century later by Fioravante Martinelli, who listed the Colosseum at the head of a list of places sacred to the martyrs in his 1653 book Roma ex ethnica sacra.
Martinelli's book evidently had an effect on public opinion; in response to Cardinal Altieri's proposal some years later to turn the Colosseum into a bullring, Carlo Tomassi published a pamphlet in protest against what he regarded as an act of desecration. The ensuing controversy persuaded Pope Clement X to close the Colosseum's external arcades and declare it a sanctuary, though quarrying continued for some time.
At the instance of St. Leonard of Port Maurice, Pope Benedict XIV (1740–1758) forbade the quarrying of the Colosseum and erected Stations of the Cross around the arena, which remained until February 1874. St. Benedict Joseph Labre spent the later years of his life within the walls of the Colosseum, living on alms, prior to his death in 1783. Several 19th century popes funded repair and restoration work on the Colosseum, and it still retains a Christian connection today. Crosses stand in several points around the arena and every Good Friday the Pope leads a Via Crucis procession to the amphitheatre.
Coliseu (Colosseo)
A seguir, um texto, em português, da Wikipédia, a enciclopédia livre:
O Coliseu, também conhecido como Anfiteatro Flaviano, deve seu nome à expressão latina Colosseum (ou Coliseus, no latim tardio), devido à estátua colossal de Nero, que ficava perto a edificação. Localizado no centro de Roma, é uma excepção de entre os anfiteatros pelo seu volume e relevo arquitectónico. Originalmente capaz de albergar perto de 50 000 pessoas, e com 48 metros de altura, era usado para variados espetáculos. Foi construído a leste do fórum romano e demorou entre 8 a 10 anos a ser construído.
O Coliseu foi utilizado durante aproximadamente 500 anos, tendo sido o último registro efetuado no século VI da nossa era, bastante depois da queda de Roma em 476. O edifício deixou de ser usado para entretenimento no começo da era medieval, mas foi mais tarde usado como habitação, oficina, forte, pedreira, sede de ordens religiosas e templo cristão.
Embora esteja agora em ruínas devido a terremotos e pilhagens, o Coliseu sempre foi visto como símbolo do Império Romano, sendo um dos melhores exemplos da sua arquitectura. Actualmente é uma das maiores atrações turísticas em Roma e em 7 de julho de 2007 foi eleita umas das "Sete maravilhas do mundo moderno". Além disso, o Coliseu ainda tem ligações à igreja, com o Papa a liderar a procissão da Via Sacra até ao Coliseu todas as Sextas-feiras Santas.
O coliseu era um local onde seriam exibidos toda uma série de espectáculos, inseridos nos vários tipos de jogos realizados na urbe. Os combates entre gladiadores, chamados muneras, eram sempre pagos por pessoas individuais em busca de prestígio e poder em vez do estado. A arena (87,5 m por 55 m) possuía um piso de madeira, normalmente coberto de areia para absorver o sangue dos combates (certa vez foi colocada água na representação de uma batalha naval), sob o qual existia um nível subterrâneo com celas e jaulas que tinham acessos diretos para a arena; Alguns detalhes dessa construção, como a cobertura removível que poupava os espectadores do sol, são bastante interessantes, e mostram o refinamento atingido pelos construtores romanos. Formado por cinco anéis concêntricos de arcos e abóbadas, o Coliseu representa bem o avanço introduzido pelos romanos à engenharia de estruturas. Esses arcos são de concreto (de cimento natural) revestidos por alvenaria. Na verdade, a alvenaria era construída simultaneamente e já servia de forma para a concretagem. Outro tipo de espetáculos era a caça de animais, ou venatio, onde eram utilizados animais selvagens importados de África. Os animais mais utilizados eram os grandes felinos como leões, leopardos e panteras, mas animais como rinocerontes, hipopótamos, elefantes, girafas, crocodilos e avestruzes eram também utilizados. As caçadas, tal como as representações de batalhas famosas, eram efetuadas em elaborados cenários onde constavam árvores e edifícios amovíveis.
Estas últimas eram por vezes representadas numa escala gigante; Trajano celebrou a sua vitória em Dácia no ano 107 com concursos envolvendo 11 000 animais e 10 000 gladiadores no decorrer de 123 dias.
Segundo o documentário produzido pelo canal televisivo fechado, History Channel, o Coliseu também era utilizado para a realização de naumaquias, ou batalhas navais. O coliseu era inundado por dutos subterrâneos alimentados pelos aquedutos que traziam água de longe. Passada esta fase, foi construída uma estrutura, que é a que podemos ver hoje nas ruínas do Coliseu, com altura de um prédio de dois andares, onde no passado se concentravam os gladiadores, feras e todo o pessoal que organizava os duelos que ocorreriam na arena. A arena era como um grande palco, feito de madeira, e se chama arena, que em italiano significa areia, porque era jogada areia sob a estrutura de madeira para esconder as imperfeições. Os animais podiam ser inseridos nos duelos a qualquer momento por um esquema de elevadores que surgiam em alguns pontos da arena; o filme "Gladiador" retrata muito bem esta questão dos elevadores. Os estudiosos, há pouco tempo, descobriram uma rede de dutos inundados por baixo da arena do Coliseu. Acredita-se que o Coliseu foi construído onde, outrora, foi o lago do Palácio Dourado de Nero; O imperador Vespasiano escolheu o local da construção para que o mal causado por Nero fosse esquecido por uma construção gloriosa.
Sylvae, ou recreações de cenas naturais eram também realizadas no Coliseu. Pintores, técnicos e arquitectos construiriam simulações de florestas com árvores e arbustos reais plantados no chão da arena. Animais seriam então introduzidos para dar vida à simulação. Esses cenários podiam servir só para agrado do público ou como pano de fundo para caçadas ou dramas representando episódios da mitologia romana, tão autênticos quanto possível, ao ponto de pessoas condenadas fazerem o papel de heróis onde eram mortos de maneiras horríveis mas mitologicamente autênticas, como mutilados por animais ou queimados vivos.
Embora o Coliseu tenha funcionado até ao século VI da nossa Era, foram proibidos os jogos com mortes humanas desde 404, sendo apenas massacrados animais como elefantes, panteras ou leões.
O Coliseu era sobretudo um enorme instrumento de propaganda e difusão da filosofia de toda uma civilização, e tal como era já profetizado pelo monge e historiador inglês Beda na sua obra do século VII "De temporibus liber": "Enquanto o Coliseu se mantiver de pé, Roma permanecerá; quando o Coliseu ruir, Roma ruirá e quando Roma cair, o mundo cairá".
A construção do Coliseu foi iniciada por Vespasiano, nos anos 70 da nossa era. O edifício foi inaugurado por Tito, em 80, embora apenas tivesse sido finalizado poucos anos depois. Empresa colossal, este edifício, inicialmente, poderia sustentar no seu interior cerca de 50 000 espectadores, constando de três andares. Aquando do reinado de Alexandre Severo e Gordiano III, é ampliado com um quarto andar, podendo suster agora cerca de 90 000 espectadores. A grandiosidade deste monumento testemunha verdadeiramente o poder e esplendor de Roma na época dos Flávios.
Os jogos inaugurais do Coliseu tiveram lugar ano 80, sob o mandato de Tito, para celebrar a finalização da construção. Depois do curto reinado de Tito começar com vários meses de desastres, incluindo a erupção do Monte Vesúvio, um incêndio em Roma, e um surto de peste, o mesmo imperador inaugurou o edifício com uns jogos pródigos que duraram mais de cem dias, talvez para tentar apaziguar o público romano e os deuses. Nesses jogos de cem dias terão ocorrido combates de gladiadores, venationes (lutas de animais), execuções, batalhas navais, caçadas e outros divertimentos numa escala sem precedentes.
O Coliseu, como não se encontrava inserido numa zona de encosta, enterrado, tal como normalmente sucede com a generalidade dos teatros e anfiteatros romanos, possuía um “anel” artificial de rocha à sua volta, para garantir sustentação e, ao mesmo tempo, esta substrutura serve como ornamento ao edifício e como condicionador da entrada dos espectadores. Tal como foi referido anteriormente, possuía três pisos, sendo mais tarde adicionado um outro. É construído em mármore, pedra travertina, ladrilho e tufo (pedra calcária com grandes poros). A sua planta elíptica mede dois eixos que se estendem aproximadamente de 190 m por 155 m. A fachada compõe-se de arcadas decoradas com colunas dóricas, jónicas e coríntias, de acordo com o pavimento em que se encontravam. Esta subdivisão deve-se ao facto de ser uma construção essencialmente vertical, criando assim uma diversificação do espaço.
Os assentos eram em mármore e a cavea, escadaria ou arquibancada, dividia-se em três partes, correspondentes às diferentes classes sociais: o podium, para as classes altas; as maeniana, sector destinado à classe média; e os portici, ou pórticos, construídos em madeira, para a plebe e as mulheres. O pulvinar, a tribuna imperial, encontrava-se situada no podium e era balizada pelos assentos reservados aos senadores e magistrados. Rampas no interior do edifício facilitavam o acesso às várias zonas de onde podiam visualizar o espectáculo, sendo protegidos por uma barreira e por uma série de arqueiros posicionados numa passagem de madeira, para o caso de algum acidente. Por cima dos muros ainda são visíveis as mísulas, que sustentavam o velarium, enorme cobertura de lona destinada a proteger do sol os espectadores e, nos subterrâneos, ficavam as jaulas dos animais, bem como todas as celas e galerias necessárias aos serviços do anfiteatro.
O monumento permaneceu como sede principal dos espetáculos da urbe romana até ao período do imperador Honorius, no século V. Danificado por um terremoto no começo do mesmo século, foi alvo de uma extensiva restauração na época de Valentinianus III. Em meados do século XIII, a família Frangipani transformou-o em fortaleza e, ao longo dos séculos XV e XVI, foi por diversas vezes saqueado, perdendo grande parte dos materiais nobres com os quais tinha sido construído.
Os relatos romanos referem-se a cristãos sendo martirizados em locais de Roma descritos pouco pormenorizadamente (no anfiteatro, na arena...), quando Roma tinha numerosos anfiteatros e arenas. Apesar de muito provavelmente o Coliseu não ter sido utilizado para martírios, o Papa Bento XIV consagrou-o no século XVII à Paixão de Cristo e declarou-o lugar sagrado. Os trabalhos de consolidação e restauração parcial do monumento, já há muito em ruínas, foram feitos sobretudo pelos pontífices Gregório XVI e Pio IX, no século XIX.
For some reason, full-sized pickup trucks are built with a very high bed. My old mid-sized pickup had a bed you could lean over and reach into. The sides on the new pickup are higher than my shoulder.
For that reason, I frequently have to climb into the back of the pickup. When the tailgate is up, I can step on the hitch and then up onto the bumper and into the bed. When the tailgate is down, I can't step on the hitch because the tailgate covers it, so I have been stepping up onto the rear tire and pulling myself up into the bed. Also, just getting into the driver's seat is an effort so I put an aftermarket step on the side so I can get into the truck in two steps.
I don't know why they are built so high. There's no good reason for it. It can't be for clearance, because the clearance is defined by the axle, not the body. The tires are a bit larger than the old truck, but that only makes the clearance a couple inches higher. The bed is at least a foot higher. The only reason I can think of is style. Making the truck higher makes it look bigger. I'd much prefer it to be unstylishly low like my old truck.
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The modification to accommodate 11 modules, just like all the others, involves the changing of the angle of just one fold. This is another close estimate for the angle. Therefore, during the initial assembling of the modules, the centre "hole" of the model is not regular. The Modules can be adjusted to form a regular hole in the centre by simply inserting a finger through it and give the model a little spin. 7.5cm squares Duo-coloured papers are used for this assembly. Many thanks to Andrey Hechuev for sharing this excellent modular.
No diagrams for my modification of the modules but video tutorial of the original 8-Piece New-Found Hope Star is posted here -
I just picked up two Pentax AF360FGZ flashes for a decent price on the PentaxForums. The price was low because neither of them were usable due to the ubiquitous battery door problem (if you are not familiar with this "feature" of the AF360FGZ, do a google search).
Anyway, I took a chance that I could modify them to accept an external 6v power supply, thereby bypassing the battery door issue altogether. Searching the web I came up with very little about repairing a AF360FGZ nor could I find exploded diagrams nor wiring diagrams. So I set about this afternoon trying to figure out how these puppies are constructed. With a little fiddling around (and a bit of difficulty since the one I chose first just so happened to have been "glued" together -- something which I assume was due to a previous fall) I was able to take apart the first AF360FGZ unit. The attached photo shows the relationships of all the primary components. I determined that the only "free" space within the unit was beneath the AF spotbeam emitter. This is where I will add a 5.5mm x 2.1mm female power socket.
Once these arrive from China I will complete the mod and let you know how it works. In the meantime, I am posting it here on the assumption there is may be some interest in this mod by Pentax shooters.
Comments welcomed.
Here are some modifications to the 2023 UCS X-Wing Starfighter set 75355. The landing gear stand is the biggest addition, I've also made subtle changes to the nose of the ship and added an almost correctly scaled R2-D2. Free instructions and parts lists for all three mods are on Rebrickable.
rebrickable.com/mocs/MOC-149544/ron_mcphatty/ucs-x-wing-s...
The Landing Gear Stand provides an easy way to display the X-Wing on a coffee table. The ship doesn't need to be modified at all, just lifted off the set's original stand and slotted onto the positioning support. The gear are built into the stand itself!
As a seperate mod I've rebuilt the top surface of the nose section to give it a bit of a slope, hopefully improving the very flat looking nose. The side panels need some slight modifications to fill some gaps and I've made the nose grey, just out of personal perference.
The midi-scale R2-D2 is slightly too large but I think looks good next to the ship when landed! Huge thanks to Jan Woźnica for letting me use his very clever R2 design and make some adjustments, please check out his instagram (@john.carter.creations) and his awesome Tales of The Space Age Lego Ideas set!
World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5)
_-----------------------------------------
The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021
*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety
*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)
——————————————————————————
(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021
-------------------------------------------------- ---------------------
According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.
The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.
, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent
What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of the cell. The ribosome is the place where protein biosynthesis occurs.
Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.
Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell
(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology
(2) New crown vaccine design, molecular biology and chemical structure, etc.
(3) The generality and particularity of the development of new coronavirus drugs
(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.
(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.
(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities
(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.
(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.
(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.
(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus
(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and
The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.
(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,
Hepatitis virus,
Marburg virus
Sars coronavirus, plague, anthracnose, cholera
and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.
However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.
Delta mutant strain
According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.
At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.
(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.
(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.
And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.
, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.
Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2～8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.
World leader, international leader, scientist, medical scientist, virologist, philosopher, thinker, cosmologist, sociologist, and Professor Fangruida
World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5)
_-----------------------------------------
The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021
*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety
*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)
——————————————————————————
(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021
-------------------------------------------------- ---------------------
According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.
The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.
, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent
What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of the cell. The ribosome is the place where protein biosynthesis occurs.
Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.
Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell
(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology
(2) New crown vaccine design, molecular biology and chemical structure, etc.
(3) The generality and particularity of the development of new coronavirus drugs
(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.
(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.
(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities
(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.
(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.
(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.
(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus
(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and
The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.
(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,
Hepatitis virus,
Marburg virus
Sars coronavirus, plague, anthracnose, cholera
and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.
However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.
Delta mutant strain
According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.
At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.
(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.
(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.
And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.
, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.
Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2～8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.
(2) Live attenuated vaccine: It is a vaccine made by using artificial targeted mutation methods or by screening live microorganisms with highly weakened or basically non-toxic virulence from the natural world. After inoculation, the live attenuated vaccine has a certain ability to grow and reproduce in the body, which can cause the body to have a reaction similar to a recessive infection or a mild infection, and it is widely used.
(3) Subunit vaccine: Among the multiple specific antigenic determinants carried by macromolecular antigens, only a small number of antigenic sites play an important role in the protective immune response. Separate natural proteins through chemical decomposition or controlled proteolysis, and extract bacteria and virusesVaccines made from fragments with immunological activity are screened out of the special protein structure of, called subunit vaccines. Subunit vaccines have only a few major surface proteins, so they can eliminate antibodies induced by many unrelated antigens, thereby reducing the side effects of the vaccine and related diseases and other side effects caused by the vaccine. (4) Genetically engineered vaccine: It uses DNA recombination biotechnology to direct the natural or synthetic genetic material in the pathogen coat protein that can induce the body's immune response into bacteria, yeast or mammalian cells to make it fully expressed. A vaccine prepared after purification. The application of genetic engineering technology can produce subunit vaccines that do not contain infectious substances, stable attenuated vaccines with live viruses as carriers, and multivalent vaccines that can prevent multiple diseases. This is the second-generation vaccine following the first-generation traditional vaccine. It has the advantages of safety, effectiveness, long-term immune response, and easy realization of combined immunization. It has certain advantages and effects.
New coronavirus drug development, drug targets and chemical modification.
Ligand-based drug design (or indirect drug design planning) relies on the knowledge of other molecules that bind to the target biological target. These other molecules can be used to derive pharmacophore models and structural modalities, which define the minimum necessary structural features that the molecule must have in order to bind to the target. In other words, a model of a biological target can be established based on the knowledge of the binding target, and the model can be used to design new molecular entities and other parts that interact with the target. Among them, the quantitative structure-activity relationship (QSAR) is included, in which the correlation between the calculated properties of the molecule and its experimentally determined biological activity can be derived. These QSAR relationships can be used to predict the activity of new analogs. The structure-activity relationship is very complicated.
Based on structure
Structure-based drug design relies on knowledge of the three-dimensional structure of biological targets obtained by methods such as X-ray crystallography or NMR spectroscopy and quantum chemistry. If the experimental structure of the target is not available, it is possible to create a homology model of the target and other standard models that can be compared based on the experimental structure of the relevant protein. Using the structure of biological targets, interactive graphics and medical chemists’ intuitive design can be used to predict drug candidates with high affinity and selective binding to the target. Various automatic calculation programs can also be used to suggest new drug candidates.
The current structure-based drug design methods can be roughly divided into three categories. The 3D method is to search a large database of small molecule 3D structures to find new ligands for a given receptor, in order to use a rapid approximate docking procedure to find those suitable for the receptor binding pocket. This method is called virtual screening. The second category is the de novo design of new ligands. In this method, by gradually assembling small fragments, a ligand molecule is established within the constraints of the binding pocket. These fragments can be single atoms or molecular fragments. The main advantage of this method is that it can propose novel structures that are not found in any database. The third method is to optimize the known ligand acquisition by evaluating the proposed analogs in the binding cavity.
Bind site ID
Binding site recognition is a step in structure-based design. If the structure of the target or a sufficiently similar homologue is determined in the presence of the bound ligand, the ligand should be observable in that structure, in which case the location of the binding site is small. However, there may not be an allosteric binding site of interest. In addition, only apo protein structures may be available, and it is not easy to reliably identify unoccupied sites that have the potential to bind ligands with high affinity. In short, the recognition of binding sites usually depends on the recognition of pits. The protein on the protein surface can hold molecules the size of drugs, etc. These molecules also have appropriate "hot spots" that drive ligand binding, hydrophobic surfaces, hydrogen bonding sites, and so on.
Drug design is a creative process of finding new drugs based on the knowledge of biological targets. The most common type of drug is small organic molecules that activate or inhibit the function of biomolecules, thereby producing therapeutic benefits for patients. In the most important sense, drug design involves the design of molecules with complementary shapes and charges that bind to their interacting biomolecular targets, and therefore will bind to them. Drug design often but does not necessarily rely on computer modeling techniques. A more accurate term is ligand design. Although the design technology for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, etc., which must be optimized first before the ligand can become safe and effective. drug. These other features are usually difficult to predict and realize through reasonable design techniques. However, due to the high turnover rate, especially in the clinical stage of drug development, in the early stage of the drug design process, more attention is paid to the selection of drug candidates. The physical and chemical properties of these drug candidates are expected to be reduced during the development process. Complications are therefore more likely to lead to the approval of the marketed drug. In addition, in early drug discovery, in vitro experiments with computational methods are increasingly used to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological characteristics. A more accurate term is ligand design. Although the design technique for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, iatrogenic effects, etc., which must be optimized first, and then the ligand To become safe and effective.
For drug targets, two aspects should be considered when selecting drug targets:
1. The effectiveness of the target, that is, the target is indeed related to the disease, and the symptoms of the disease can be effectively improved by regulating the physiological activity of the target.
2. The side effects of the target. If the regulation of the physiological activity of the target inevitably produces serious side effects, it is inappropriate to select it as the target of drug action or lose its important biological activity. The reference frame of the target should be expanded in multiple dimensions to have a big choice.
3. Search for biomolecular clues related to diseases: use genomics, proteomics and biochip technology to obtain biomolecular information related to diseases, and perform bioinformatics analysis to obtain clue information.
4. Perform functional research on related biomolecules to determine the target of candidate drugs. Multiple targets or individual targets.
5. Candidate drug targets, design small molecule compounds, and conduct pharmacological research at the molecular, cellular and overall animal levels.
Covalent bonding type
The covalent bonding type is an irreversible form of bonding, similar to the organic synthesis reaction that occurs. Covalent bonding types mostly occur in the mechanism of action of chemotherapeutic drugs. For example, alkylating agent anti-tumor drugs produce covalent bonding bonds to guanine bases in DNA, resulting in cytotoxic activity.
. Verify the effectiveness of the target.
Based on the targets that interact with drugs, that is, receptors in a broad sense, such as enzymes, receptors, ion channels, membranes, antigens, viruses, nucleic acids, polysaccharides, proteins, enzymes, etc., find and design reasonable drug molecules. Targets of action and drug screening should focus on multiple points. Drug intermediates and chemical modification. Combining the development of new drugs with the chemical structure modification of traditional drugs makes it easier to find breakthroughs and develop new antiviral drugs. For example, careful selection, modification and modification of existing related drugs that can successfully treat and recover a large number of cases, elimination and screening of invalid drugs from severe death cases, etc., are targeted, rather than screening and capturing needles in a haystack, aimless, with half the effort. Vaccine design should also be multi-pronged and focused. The broad-spectrum, long-term, safety, efficiency and redundancy of the vaccine should all be considered. In this way, it will be more powerful to deal with the mutation and evolution of the virus. Of course, series of vaccines, series of drugs, second-generation vaccines, third-generation vaccines, second-generation drugs, third-generation drugs, etc. can also be developed. Vaccines focus on epidemic prevention, and medicines focus on medical treatment. The two are very different; however, the two complement each other and complement each other. Therefore, in response to large-scale epidemics of infectious diseases, vaccines and various drugs are the nemesis and killers of viral diseases. Of course, it also includes other methods and measures, so I won't repeat them here.
Mainly through the comprehensive and accurate understanding of the structure of the drug and the receptor at the molecular level and even the electronic level, structure-based drug design and the understanding of the structure, function, and drug action mode of the target and the mechanism of physiological activity Mechanism-based drug design.
Compared with the traditional extensive pharmacological screening and lead compound optimization, it has obvious advantages.
Viral RNA replicase, also known as RNA-dependent RNA polymerase (RdRp) is responsible for the replication and transcription of RNA virus genome, and plays a very important role in the process of virus self-replication in host cells, and It also has a major impact on the mutation of the virus, it will change and accelerate the replication and recombination. Because RdRp from different viruses has a highly conserved core structure, the virus replicase is an important antiviral drug target and there are other selection sites, rather than a single isolated target target such as the new coronavirus As with various mutant viruses, inhibitors developed for viral replicase are expected to become a broad-spectrum antiviral drug. The currently well-known anti-coronavirus drug remdesivir (remdesivir) is a drug for viral replicase.
New antiviral therapies are gradually emerging. In addition to traditional polymerase and protease inhibitors, nucleic acid drugs, cell entry inhibitors, nucleocapsid inhibitors, and drugs targeting host cells are also increasingly appearing in the research and development of major pharmaceutical companies. The treatment of mutated viruses is becoming increasingly urgent. The development of drugs for the new coronavirus pneumonia is very important. It is not only for the current global new coronavirus epidemic, but more importantly, it is of great significance to face the severe pneumonia-respiratory infectious disease that poses a huge threat to humans.
There are many vaccines and related drugs developed for the new coronavirus pneumonia, and countries are vying for a while, mainly including the following:
Identification test, appearance, difference in loading, moisture, pH value, osmolality, polysaccharide content, free polysaccharide content, potency test, sterility test, pyrogen test, bacterial endotoxin test, abnormal toxicity test.
Among them: such as sterility inspection, pyrogen inspection, bacterial endotoxin, and abnormal toxicity inspection are indicators closely related to safety.
Polysaccharide content, free polysaccharide content, and efficacy test are indicators closely related to vaccine effectiveness.
Usually, a vaccine will go through a long research and development process of at least 8 years or even more than 20 years from research and development to marketing. The outbreak of the new crown epidemic requires no delay, and the design and development of vaccines is speeding up. It is not surprising in this special period. Of course, it is understandable that vaccine design, development and testing can be accelerated, shortened the cycle, and reduced some procedures. However, science needs to be rigorous and rigorous to achieve great results. The safety and effectiveness of vaccines are of the utmost importance. There must not be a single error. Otherwise, it will be counterproductive and need to be continuously improved and perfected.
Pre-clinical research: The screening of strains and cells is the basic guarantee to ensure the safety, effectiveness, and continuous supply of vaccines. Taking virus vaccines as an example, the laboratory stage needs to carry out strain screening, necessary strain attenuation, strain adaptation to the cultured cell matrix and stability studies in the process of passaging, and explore the stability of process quality, establish animal models, etc. . Choose mice, guinea pigs, rabbits or monkeys for animal experiments according to each vaccine situation. Pre-clinical research generally takes 5-10 years or longer on the premise that the process is controllable, the quality is stable, and it is safe and effective. In order to be safe and effective, a certain redundant design is also needed, so that the safety and effectiveness of the vaccine can be importantly guaranteed.
These include the establishment of vaccine strain/cell seed bank, production process research, quality research, stability research, animal safety evaluation and effectiveness evaluation, and clinical trial programs, etc.
The ARS-CoV-2 genome contains at least 10 ORFs. ORF1ab is converted into a polyprotein and processed into 16 non-structural proteins (NSP). These NSPs have a variety of functional biological activities, physical and chemical reactions, such as genome replication, induction of host mRNA cleavage, membrane rearrangement, autophagosome production, NSP polyprotein cleavage, capping, tailing, methylation, RNA double-stranded Uncoiling, etc., and others, play an important role in the virus life cycle. In addition, SARS-CoV-2 contains 4 structural proteins, namely spike (S), nucleocapsid (N), envelope (E) and membrane (M), all of which are encoded by the 3'end of the viral genome. Among the four structural proteins, S protein is a large multifunctional transmembrane protein that plays an important role in the process of virus adsorption, fusion, and injection into host cells, and requires in-depth observation and research.
1S protein is composed of S1 and S2 subunits, and each subunit can be further divided into different functional domains. The S1 subunit has 2 domains: NTD and RBD, and RBD contains conservative RBM. The S2 subunit has 3 structural domains: FP, HR1 and HR2. The S1 subunit is arranged at the top of the S2 subunit to form an immunodominant S protein.
The virus uses the host transmembrane protease Serine 2 (TMPRSS2) and the endosomal cysteine protease CatB/L to enter the cell. TMPRSS2 is responsible for the cleavage of the S protein to expose the FP region of the S2 subunit, which is responsible for initiating endosome-mediated host cell entry into it. It shows that TMPRSS2 is a host factor necessary for virus entry. Therefore, the use of drugs that inhibit this protease can achieve the purpose of treatment.
mRNA-1273
The mRNA encoding the full length of SARS-CoV-2, and the pre-spike protein fusion is encapsulated into lipid nanoparticles to form mRNA-1273 vaccine. It can induce a high level of S protein specific antiviral response. It can also consist of inactivated antigens or subunit antigens. The vaccine was quickly approved by the FDA and has entered phase II clinical trials. The company has announced the antibody data of 8 subjects who received different immunization doses. The 25ug dose group achieved an effect similar to the antibody level during the recovery period. The 100ug dose group exceeded the antibody level during the recovery period. In the 25ug and 100ug dose groups, the vaccine was basically safe and tolerable, while the 250ug dose group had 3 levels of systemic symptoms.
Viral vector vaccines can provide long-term high-level expression of antigen proteins, induce CTLs, and ultimately eliminate viral infections.
1, Ad5-nCov
A vaccine of SARS-CoV-2 recombinant spike protein expressed by recombinant, replication-deficient type 5 adenovirus (Ad5) vector. Load the optimized full-length S protein gene together with the plasminogen activation signal peptide gene into the E1 and E3 deleted Ad5 vectors. The vaccine is constructed by the Admax system derived from Microbix Biosystem. In phase I clinical trials, RBD (S1 subunit receptor binding domain) and S protein neutralizing antibody increased by 4 times 14 days after immunization, reaching a peak on 28 days. CD4+T and CD8+T cells reached a peak 14 days after immunization. The existing Ad5 immune resistance partially limits the response of antibodies and T cells. This study will be further conducted in the 18-60 age group, receiving 1/3 of the study dose, and follow-up for 3-6 months after immunization.
DNA vaccine
The introduction of antigen-encoding DNA and adjuvants as vaccines is the most innovative vaccine method. The transfected cells stably express the transgenic protein, similar to live viruses. The antigen will be endocytosed by immature DC, and finally provide antigen to CD4 + T, CD8 + T cells (by MHC differentiation) To induce humoral and cellular immunity. Some specificities of the virus and the new coronavirus mutant are different from general vaccines and other vaccines. Therefore, it is worth noting the gene expression of the vaccine. Otherwise, the effectiveness and efficiency of the vaccine will be questioned.
Live attenuated vaccine
DelNS1-SARS-CoV2-RBD
Basic influenza vaccine, delete NS1 gene. Express SARS-CoV-2 RBD domain. Cultured in CEF and MDCK (canine kidney cells) cells. It is more immunogenic than wild-type influenza virus and can be administered by nasal spray.
The viral genome is susceptible to mutation, antigen transfer and drift can occur, and spread among the population. Mutations can vary depending on the environmental conditions and population density of the geographic area. After screening and comparing 7,500 samples of infected patients, scientists found 198 mutations, indicating the evolutionary mutation of the virus in the human host. These mutations may form different virus subtypes, which means that even after vaccine immunization, viral infections may occur. A certain amount of increment and strengthening is needed here.
Inactivated vaccines, adenovirus vector vaccines, recombinant protein vaccines, nucleic acid vaccines, attenuated influenza virus vector vaccines, etc. According to relevant information, there are dozens of new coronavirus vaccines in the world, and more varieties are being developed and upgraded. Including the United States, Britain, China, Russia, India and other countries, there are more R&D and production units.
AZ vaccine
Modena vaccine
Lianya Vaccine
High-end vaccine
Pfizer vaccine
Pfizer-BioNTech
A large study found that the vaccine developed by Pfizer and German biotechnology company BioNTech is 95% effective in preventing COVID-19.
The vaccine is divided into two doses, which are injected every three weeks.
This vaccine uses a molecule called mRNA as its basis. mRNA is a molecular cousin of DNA, which contains instructions to build specific proteins; in this case, the mRNA in the vaccine encodes the coronavirus spike protein, which is attached to the surface of the virus and used to infect human cells. Once the vaccine enters the human body, it will instruct the body's cells to make this protein, and the immune system will learn to recognize and attack it.
Moderna
The vaccine developed by the American biotechnology company Moderna and the National Institute of Allergy and Infectious Diseases (NIAID) is also based on mRNA and is estimated to be 94.5% effective in preventing COVID-19.
Like Pfizer's vaccine, this vaccine is divided into two doses, but injected every four weeks instead of three weeks. Another difference is that the Moderna vaccine can be stored at minus 20 degrees Celsius instead of deep freezing like Pfizer vaccine. At present, the importance of one of the widely used vaccines is self-evident.
Oxford-AstraZeneca
The vaccine developed by the University of Oxford and the pharmaceutical company AstraZeneca is approximately 70% effective in preventing COVID-19-that is, in clinical trials, adjusting the dose seems to improve this effect.
In the population who received two high-dose vaccines (28 days apart), the effectiveness of the vaccine was about 62%; according to early analysis, the effectiveness of the vaccine in those patients who received the half-dose first and then the full-dose Is 90%. However, in clinical trials, participants taking half doses of the drug are wrong, and some scientists question whether these early results are representative.
Sinopharm Group (Beijing Institute of Biological Products, China)
China National Pharmaceutical Group Sinopharm and Beijing Institute of Biological Products have developed a vaccine from inactivated coronavirus (SARS-CoV-2). The inactivated coronavirus is an improved version that cannot be replicated.
Estimates of the effectiveness of vaccines against COVID-19 vary.
Gamaleya Institute
The Gamaleya Institute of the Russian Ministry of Health has developed a coronavirus vaccine candidate called Sputnik V. This vaccine contains two common cold viruses, adenoviruses, which have been modified so that they will not replicate in the human body; the modified virus also contains a gene encoding the coronavirus spike protein.
New crown drugs
There are many small molecule antiviral drug candidates in the clinical research stage around the world. Including traditional drugs in the past and various drugs yet to be developed, antiviral drugs, immune drugs, Gene drugs, compound drugs, etc.
(A) Molnupiravir
Molnupiravir is a prodrug of the nucleoside analog N4-hydroxycytidine (NHC), jointly developed by Merck and Ridgeback Biotherapeutics.
The positive rate of infectious virus isolation and culture in nasopharyngeal swabs was 0% (0/47), while that of patients in the placebo group was 24% (6/25). However, data from the Phase II/III study indicate that the drug has no benefit in preventing death or shortening the length of stay in hospitalized patients.
Therefore, Merck has decided to fully advance the research of 800mg molnupiravir in the treatment of patients with mild to moderate COVID-19.
(B) AT-527
AT-527 is a small molecule inhibitor of viral RNA polymerase, jointly developed by Roche and Atea. Not only can it be used as an oral therapy to treat hospitalized COVID-19 patients, but it also has the potential as a preventive treatment after exposure.
Including 70 high-risk COVID-19 hospitalized patients data, of which 62 patients' data can be used for virological analysis and evaluation. The results of interim virological analysis show that AT-527 can quickly reduce viral load. On day 2, compared with placebo, patients treated with AT-527 had a greater decline in viral load than the baseline level, and the continuous difference in viral load decline was maintained until day 8.
In addition, compared with the control group, the potent antiviral activity of AT-527 was also observed in patients with a baseline median viral load higher than 5.26 log10. When testing by RT-qPCR to assess whether the virus is cleared,
The safety aspect is consistent with previous studies. AT-527 showed good safety and tolerability, and no new safety problems or risks were found. Of course, there is still a considerable distance between experiment and clinical application, and a large amount of experimental data can prove it.
(C) Prokrutamide
Prokalamide is an AR (androgen receptor) antagonist. Activated androgen receptor AR can induce the expression of transmembrane serine protease (TMPRSS2). TMPRSS2 has a shearing effect on the new coronavirus S protein and ACE2, which can promote the binding of viral spike protein (S protein) to ACE, thereby promoting The virus enters the host cell. Therefore, inhibiting the androgen receptor may inhibit the viral infection process, and AR antagonists are expected to become anti-coronavirus drugs.
Positive results were obtained in a randomized, double-blind, placebo-controlled phase III clinical trial. The data shows that Prokalutamide reduces the risk of death in severely ill patients with new coronary disease by 92%, reduces the risk of new ventilator use by 92%, and shortens the length of hospital stay by 9 days. This shows that procrulamide has a certain therapeutic effect for patients with severe new coronary disease, which can significantly reduce the mortality of patients, and at the same time greatly reduce the new mechanical ventilation and shorten the patient's hospital stay.
With the continuous development of COVID-19 on a global scale, in addition to vaccines and prevention and control measures, we need a multi-pronged plan to control this disease. Oral antiviral therapy undoubtedly provides a convenient treatment option.
In addition, there are other drugs under development and experimentation. In dealing with the plague virus, in addition to the strict control of protective measures, it is very important that various efficient and safe vaccines and various drugs (including medical instruments, etc.) are the ultimate nemesis and killer of the virus.
(A) "Antiviral biological missiles" are mainly drugs for new coronaviruses and mutant viruses, which act on respiratory and lung diseases. The drugs use redundant designs to inhibit new coronaviruses and variant viruses.
(B) "New Coronavirus Epidemic Prevention Tablets" mainly use natural purified elements and chemical structure modifications.
(C) "Composite antiviral oral liquid" antiviral intermediate, natural antiviral plant, plus other preparations
(D) "New Coronavirus Long-acting Oral Tablets" Chemical modification of antiviral drugs, multiple targets, etc.
(E) "New Coronavirus Inhibitors" (injections) are mainly made of chemical drug structure modification and other preparations.
The development of these drugs mainly includes: drug target screening, structure-activity relationship, chemical modification, natural purification, etc., which require a lot of work and experimentation.
Humans need to vigorously develop drugs to deal with various viruses. These drugs are very important for the prevention and treatment of viruses and respiratory infectious diseases, influenza, pneumonia, etc.
The history of human development The history of human evolution, like all living species, will always be accompanied by the survival and development of microorganisms. It is not surprising that viruses and infectious diseases are frequent and prone to occur. The key is to prevent and control them before they happen.
This strain was first discovered in India in October 2020 and was initially called a "double mutant" virus by the media. According to the announcement by the Ministry of Health of India at the end of March this year, the "India New Coronavirus Genomics Alliance" composed of 10 laboratories found in samples collected in Maharashtra that this new mutant strain carries E484Q and L452R mutations. , May lead to immune escape and increased infectivity. This mutant strain was named B.1.617 by the WHO and was named with the Greek letter δ (delta) on May 31.
Shahid Jamil, the dean of the Trivedi School of Biological Sciences at Ashoka University in India and a virologist, said in an interview with the Shillong Times of India that this mutant strain called "double mutation" is not accurate enough. B. 1.617 contains a total of 15 mutations, of which 6 occur on the spike protein, of which 3 are more critical: L452R and E484Q mutations occur on the spike protein and the human cell "Angiotensin Converting Enzyme 2 (ACE2)" receptor In the bound region, L452R improves the ability of the virus to invade cells, and E484Q helps to enhance the immune escape of the virus; the third mutation P681R can also make the virus enter the cell more effectively. (Encyclopedia website)
There are currently dozens of antiviral COVID-19 therapies under development. The large drugmakers Merck and Pfizer are the closest to the end, as expected, a pair of oral antiviral COVID-19 therapies are undergoing advanced human clinical trials.
Merck's drug candidate is called monupiravir. It was originally developed as an influenza antiviral drug several years ago. However, preclinical studies have shown that it has a good effect on SARS and MERS coronavirus.
Monupiravir is currently undergoing in-depth large-scale Phase 3 human trials. So far, the data is so promising that the US government recently pre-ordered 1.7 million courses of drugs at a cost of $1.2 billion. If everything goes according to plan, the company hopes that the drug will be authorized by the FDA for emergency use and be on the market before the end of 2021.
Pfizer's large COVID-19 antiviral drug candidate is more unique. Currently known as PF-07321332, this drug is the first oral antiviral drug to enter human clinical trials, specifically targeting SARS-CoV-2.
Variant of Concern WHO Label First Detected in World First Detected in Washington State
B.1.1.7 Alpha United Kingdom, September 2020 January 2021
B.1.351 Beta South Africa, December 2020 February 2021
P.1 Gamma Brazil, April 2020 March 2021
B.1.617.2 Delta India, October 2020 April 2021
Although this particular molecule was developed in 2020 after the emergence of the new coronavirus, a somewhat related drug called PF-00835231 has been in operation for several years, targeting the original SARS virus. However, the new drug candidate PF-07321332 is designed as a simple pill that can be taken under non-hospital conditions in the initial stages of SARS-CoV-2 infection.
"The protease inhibitor binds to a viral enzyme and prevents the virus from replicating in the cell," Pfizer said when explaining the mechanism of its new antiviral drug. "Protease inhibitors have been effective in the treatment of other viral pathogens, such as HIV and hepatitis C virus, whether used alone or in combination with other antiviral drugs. Currently marketed therapeutic drugs for viral proteases are generally not toxic Therefore, such molecules may provide well-tolerated treatments against COVID-19."
Various studies on other types of antiviral drugs are also gaining momentum. For example, the new coronavirus pneumonia "antiviral biological missile", "new coronavirus prevention tablets", "composite antiviral oral liquid", "new coronavirus long-acting oral tablets", "new coronavirus inhibitors" (injections), etc., are worthy of attention. Like all kinds of vaccines, they will play a major role in preventing and fighting epidemics.
In addition, Japanese pharmaceutical company Shionoyoshi Pharmaceutical is currently conducting a phase 1 trial of a protease inhibitor similar to SARS-CoV-2. This is called S-217622, which is another oral antiviral drug, and hopes to provide people with an easy-to-take pill in the early stages of COVID-19. At present, the research and development of vaccines and various new crown drugs is very active and urgent. Time does not wait. With the passage of time, various new crown drugs will appear on the stage one after another, bringing the gospel to the complete victory of mankind.
The COVID-19 pandemic is far from over. The Delta mutant strain has quickly become the most prominent SARS-CoV-2 strain in the world. Although our vaccine is still maintained, it is clear that we need more tools to combat this new type of coronavirus. Delta will certainly not be the last new SARS-CoV-2 variant we encountered. Therefore, it is necessary for all mankind to persevere and fight the epidemic together.
Overcome illness and meet new challenges. The new crown epidemic and various mutated viruses are very important global epidemic prevention and anti-epidemic top priorities, especially for the current period of time. Vaccine injections, research and development of new drugs, strict prevention and control, wear masks, reduce gatherings, strictly control large gatherings, prevent the spread of various viruses Masks, disinfection and sterilization, lockdown of the city, vaccinations, accounting and testing are very important, but this does not mean that humans can completely overcome the virus. In fact, many spreading and new latently transmitted infections are still unsuccessful. There are detections, such as invisible patients, asymptomatic patients, migratory latent patients, new-onset patients, etc. The struggle between humans and the virus is still very difficult and complicated, and long-term efforts and exploration are still needed, especially for medical research on the new coronavirus. The origin of the disease, the course of the disease, the virus invaded The deep-level path and the reasons for the evolution and mutation of the new coronavirus and the particularity of prevention and treatment, etc.). Therefore, human beings should be highly vigilant and must not be taken lightly. The fierce battle between humans and various viruses must not be slackened. Greater efforts are needed to successfully overcome this pandemic, fully restore the normal life of the whole society, restore the normal production and work order, restore the normal operation of society, economy and culture, and give up food due to choking. Or eager for success, will pay a high price.
———————————————————————————————————————————————— ————
References References are made to web resources, and related images are from web resources and related websites.
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Wikipedia, "The Lancet", "English Journal of Medicine", "Nature", "Science", "Journal of the American Medical Association", etc.
Learning from history: do not flatten the curve of antiviral research!
T Bobrowski, CC Melo-Filho, D Korn, VM Alves...-Drug discovery today, 2020-
A critical overview of computational approaches employed for COVID-19 drug discovery
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Adoption of a contact tracing app for containing COVID-19: a health belief model approach
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Prophylactic Treatment Protocol Against the Severity of COVID-19 Using Melatonin
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany, New England Journal of Medicine
The actions of respiratory therapists facing COVID-19
Zhu Jiacheng-Respiratory Therapy, 2021-pesquisa.bvsalud.org
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, The Lancet
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China, JAMA, February 7
Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China, JAMA
Delta variant triggers new phase in the pandemic | Science
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YH HUANG, SS LI, X YAO, YR YANG, DH QIN…-jnewmed.com
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Risk of long QT syndrome in novel coronavirus COVID-19
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Study compares mRNA and adenovirus-based SARS-CoV-2 vaccines ...
First molecular-based detection of SARS-CoV-2 virus in the field-collected houseflies
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Covid 19 DELTA Variant Archives-Online essay writing service
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Compilation postscript
Once Fang Ruida's research literature on the new crown virus and mutant virus was published, it has been enthusiastically praised by readers and netizens in dozens of countries around the world, and has proposed some amendments and suggestions. Hope to publish a multilingual version of the book as an emergency To meet the needs of many readers around the world, in the face of the new crown epidemic and the prevention and treatment of various mutant viruses, including the general public, college and middle school students, medical workers, medical colleagues and so on. According to the English original manuscript, it will be re-compiled and published. Inconsistencies will be revised separately. Thank you very much.
Jacques Lucy, Geneva, Switzerland, August 2021
*********************************************************************
Leader mondial, scientifique, scientifique médical, virologue, pharmacien et professeur Fangruida (F.D Smith) sur l'épidémie mondiale et l'ennemi juré et la prévention des nouveaux coronavirus et virus mutants (Jacques Lucy 2021v1.5)
_-----------------------------------------
L'ennemi juré et le tueur du nouveau coronavirus et des virus mutés - Développement conjoint de vaccins et de médicaments (Fangruida) Juillet 2021
* La particularité des nouveaux coronavirus et des virus mutants * Le large spectre, la haute efficacité, la redondance et la sécurité de la conception et du développement du nouveau vaccin contre le coronavirus, Redondance et sécurité
VO pre-drills their fenders for a single centered draw bolt. But a double drawbolt attachment a la Honjo provides greater lateral rigidity. But where did the center hole go???
Go to the Book with image in the Internet Archive
Title: United States Naval Medical Bulletin Vol. 6, Nos. 1-4, 1912
Creator: U.S. Navy. Bureau of Medicine and Surgery
Publisher:
Sponsor:
Contributor:
Date: 1912
Language: eng
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Table of Contents</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Number 1</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Preface v</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Special articles:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The medical man and vital statistics, by J. D. Gatewood 1</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A plea for more liberal nomenclature for the Naval Medical Service, by A.
W. Dunbar 22</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Acid fast bacilli in the circulating blood of lepers, by G. B. Crow 26</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The tenth convention of the second Hague conference of 1907, and its
relation to the evacuation of the wounded in naval warfare, by F. L. Pleadwell (second
paper) 34</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A study of 3,268 venereal prophylactic treatments, by R. C. Holcomb and
D. C. Gather 52</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A year's experience in venereal prophylaxis on board the U. S. S.
Georgia, July 1, 1910-June 30, 1911, by C. L. Moran 60</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The recent advances in the prophylaxis and treatment of typhoid fever, by
M. W. Baker 62</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">United States Medical School laboratories:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The Naval Medical School collections, by P. E. Garrison 69</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the helminthological collection, United States Naval
Medical School, September-November, 1911 72</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the pathological collection, United States Naval Medical School,
September-November, 1911 72</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Suggested devices:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Modification in shoe for prevention of blisters on the heel, by W. S.
Sims. . 73</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">An improved cot for hospital ships and sick bays aboard ship, by E. M. Blackwell
73</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Clinical notes:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Umbilical hernia, by H. F. Strine 76</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Report of a case resembling gangosa in which treponema pertenuis was present,
by P. S. Rossiter 78</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Bunion operations, by A. M. Fauntleroy 79</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Late positive Wassermann in syphilis and tuberculosis, by W. B. Grove.
... 81</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Salvarsan in frambcesia, by G. F. Cottle<span> </span><span> </span>82</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Salvarsan in filariasis, by G. F. Cottle 84</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Current comment:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The twentieth annual meeting of the Association of Military Surgeons.
... 89</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The ninth international Red Cross conference 90</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Typhoid fever 91</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Yellow fever at Honolulu 92</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Opening of the Naval Hospital, Great Lakes training station, <span> </span><span> </span>92</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Progress in medical sciences: </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">General medicine. —Pulmonary tuberculosis, experiences with, during
last year; possible infectious origin of pernicious anemia; differential diagnosis
in albuminuria; observations on urine of marathon runners; alcohol in dermal
therapeutics; baldness and its cures; relationship of syphilis and
tuberculosis; present status of salvarsan therapeutics; effect of salvarsan upon
the heart; utilization of Wassermann reaction in the Navy; possible specific
treatment of diabetes mellitus; bromidrosis and hyperidrosis</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">of the feet; by A. W. Dunbar and J. L. Neilson 93</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Surgery. —Open treatment of transverse fracture of femoral shaft; cure
of prostatic obstruction; organization at main battle dressing station; by R.
Spear 107</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Hygiene and sanitation. — A strength and endurance test; dangers to
health from automobile engine gases; decomposing power of bacteria in water; epidemic
due to Gartner bacillus; bacteriological investigation of ice cream in Boston;
emergency rations; accidents of decompression; merits of low protein diet;
concerning particles of albuminous substance in exhaled air; influence of
storage and preservatives upon dissolved oxygen in waters; bacteriological
examinations of oysters; by H. G.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Beyer and C.N. Fiske 113</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Tropical medicine. — Preliminary report on method of preventing pernicious
malaria; recent advances in knowledge of sleeping sickness; experiments on the
cause of beriberi; action of quinine, salvarsan and atoxyl on Plasmodium
prrecox in canary birds; relationship between Gl. Morsitans and sleeping
sickness; by E. R. Stitt 124</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Pathology and bacteriology. —Detection of tubercle bacilli in sputum; method
of infection in pneumonic plague; study of arteritis of syphilitic origin;
isolation of typhoid, paratyphoid and dysentery bacilli; bacteriological
examination of stools in quarantine protection against cholera; local
production of antibodies; by M. E. Higgins 130</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Medical zoology.—Etiology of pellagra, by P. E. Garrison 136</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Chemistry and pharmacy. —Determination of arsenic in urine after administering
salvarsan; method for detection of salvarsan; method for estimation of gastric
acidity; absorption of chloroform and other chlorinated hydrocarbons by men and
animals; by E. W. Brown and O. G. Ruge... 136</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Eye, ear, nose, and throat. —Acute nephritis following acute tonsillitis;
when to remove tonsils and what operation to be used; recent contributions to
knowledge of sympathetic ophthalmia; protest against indiscriminate use of
organic compounds of silver in ophthalmic practice; two cases of iritis treated
with salvarsan ; a quick and easy method for removal of eyeball; by E. M. Shipp
138</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Reports and letters:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Sanitary report on Hampton Roads, Norfolk, and vicinity, by G. A. Lung.
149</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Recent pellagra clinic at Columbia, S. C, by P. E. Garrison 152</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A visit to the Finsen Institute, by R. B. Williams 157</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Number 2</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Preface vi</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Special articles:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Lead poisoning from inhalation of red-lead laden dust. The possible frequency
of lead encephalopathy in such cases, by E. R. Stitt 161</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Loss of life by drowning in naval warfare, by T. W. Richards 166</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Etiology of gangosa, based upon complement fixation, by E. P. Halton. .
. 190</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Further observations on the insane of the Navy, by Heber Butts 193</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Roaches and their extermination by the use of sodium fluorid, by M. F. Gates
212</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The prophylaxis of boils, by E. W. Phillips 214</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Extract from sanitary report, U. S. S. Washington, by J. H. Iden 215</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Comment, by J. D. Gatewood 216</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Damage table for physical disability in the United States Navy, 1910. International
nomenclature, by C. N. Fiske 217</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Indications for intubation and tracheotomy, by G. B. Trible 219</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Report on methods of administration of and results obtained from
"salvarsan." Based upon the treatment of over 200 cases of syphilis
at the naval hospital, Mare Island, Cal., by J. A. Biello 221</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Method used at naval hospital, Chelsea, Mass., by F. M. Furlong 225</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Method used at naval hospital, Norfolk, Va., by W. M. Garton 225</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Method used at naval hospital, New York, N. Y., by C. M. Oman 226</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Distribution of tubercle bacilli in the sputa of tuberculous patients,
by R. W. King 227</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">United States Naval Medical School laboratories:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Specimens added to the helminthological collection, December, 1911-February,
1912 229</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Specimens added to the pathological collection, December,
1911-February, 1912 231</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Miscellaneous collection, December, 1911-February, 1912 231</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Suggested devices:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">An incubator for gelatine cultures, by F. L. Letts 233</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Clinical notes:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Report of a case of perforation of the sigmoid by an ulcer, in a case
of dysentery (Flexner-Strong), by Raymond Spear and M. E. Higgins 235</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Plastic operation of lip, by R. A. Bachmann 236</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Removal of entire fibula, by J. L. Neilson 236</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Frontal sinusitis, followed by double mastoiditis; operations, by G. B.
Trible 239 </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">"Salvarsan " in syphilis, leprosy, and yaws, by W. M. Kerr
240</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Two surgical cases occurring on the U. S. S. South Carolina, by R. B. Williams
242</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">1. Abscess of prostate, gangrene of scrotum, pyemia, death.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">2. Tonsillitis; tonsillectomy, acute nephritis, uremia.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Surgical cases from the naval hospital, Norfolk, Va., by H. F. Strine
243</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">1. Lacerated kidney, nephrectomy.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">2. Gastro-enterostomy.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">3. Cholecystocolostomy; external biliary fistula; stricture of common duct.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">4. Multiple abscess of liver.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Editorial comment:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Yellow fever on the Yorktown, by C. F. Stokes 249</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The Naval Medical Bulletin 260</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Hospital ships 250</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Paresis and "line of duty " 253</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Progress in medical sciences:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">General medicine. — Relation of so-called Brill's disease to typhus
fever. Diagnostic importance of hemoptysis. Acute dilatation of the stomach in
pneumonia. Reaction induced by antityphoid vaccination, by A. W. Dunbar and J.
L. Neilfon 255</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Surgery. —Organization of the medical service at the main dressing
station in battle, by H. G. Beyer. The error of overlooking ureteral or renal stones
under the diagnosis of appendicitis. The incision for lumbar</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">exposure of the kidney. Iodine as the sole dressing for operation
wounds. A review of recent methods for the radical cure of hernia. Studies in peritoneal
adhesions. The surgical treatment of colitis, by Raymond Spear and C. M. Oman
259</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Hygiene and sanitation. —A symposium on the effects of athletics on
young men, by J. L. Neilson. Mosquito larvicides, by E. R. Stitt. Sur une cause
possible du gout empyreumatique de l'eau de boisson a bord des navires de
guerre, by C. L. Moran. Organic matter in expired air. Tests for freshness of
milk, by E. W. Brown. Experiments in book disinfection. The purification of
water by anhydrous chlorine. Oral hygiene (preliminary contribution on the care
of the mouth). On the survival of specific microorganisms in pupae and imagines
of musca domestica raised from experimentally infected larvae : Experiments
with B. typhosus. On the varieties of B. coli associated with the house fly, by
C. N. Fiske. 271</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Tropical medicine. —A few words on the distribution of smallpox,
tuberculosis, and typhoid in the tropics. Do mosquitoes require blood as
nourishment in the development of their eggs? By E. R. Stitt 279</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Pathology and bacteriology. —An attempt to differentiate the
diphtheroid group of organisms. The period of infectivity of the blood of
measles; an experimental demonstration of the presence of the virus of measles
in the mixed buccal and nasal secretions; the nature of the virus of measles; the
infectivity of the secretions and disquamating scales of measles. A new
conception of immunity. Complement in human serum, by M. E. Higgins 281</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Medical zoology. —A comparative study of the ameba in the Manila water supply,
in the intestinal tract of healthy persons and in amebic dysentery. The Rocky
Mountain spotted fever tick, with special reference to the problems of its
control in Bitter Root Valley, Montana, by P. B. Garrison 283</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Chemistry and pharmacy. —Some considerations on the absorption and excretion
of drugs. Detection of albumoses in urine. Estimation of free HC1 in gastric
contents by capillary method. Detection of albumin in urine by Merck's tablets.
Estimation of acetone in animal liquids. New test for bile in urine. Method for
determining formaldehyde. Indirect method for determining total volume of
gastric contents, by E. W. Brown and O. G. Ruge 286</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Eye, ear, nose, and throat.—Abscess of the nasal septum. Observations upon
the treatment of gonorrheal conjunctivitis in the adult, by E. M. Shipp 291</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Reports and letters: </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Yellow fever occurring on board the U. S. S. Yorktown at Guayaquil, Ecuador,
extracts from a report on cases of, by C. B. Camerer 295</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Report on military surgery at Foochow, China, by J. G. Omelvena 300</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Notes on Camp Meyer, Guantanamo Bay, Cuba, by L. W. Johnson 303</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Special report on the general surgical department, Naval Hospital,
Norfolk, Va. Anesthesia. Prophylaxis of wound infection. Appendicitis. Post-operative
treatment, by H. F. Strine 305</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">American Public Health Association meeting (abstract of report on), by W.
H. Short 309</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Number 3</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Preface v</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Special articles:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Leprosy, with notes on, and illustrations of the cases as they occurred
in the Tumon Leper Colony, Guam, Marianas, during the months of October and
November, 1911, by W. M. Kerr, assistant surgeon, United States Navy 313</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Photographs of lepers, by G. F. Cottle, passed assistant surgeon,
United States Navy 342</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Vision in relation to marksmanship, by E. J. Grow, surgeon, United States
Navy 344</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Technique of a Wassermann test in which guinea-pig complement is not required;
Emery technique; Noguchi reagents, by E. R. Stitt, medical inspector, United
States Navy 362</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Some minor sanitary defects in modern battleships, and their correction,
by F. L. Pleadwell, surgeon, United States Navy 309</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additional report of cases with unusual symptoms caused by contact with
some unknown variety of jelly fish, by E. H. Old, passed assistant surgeon,
United States Navy 377</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The effects of high temperature on the personnel of the fire rooms of
naval vessels with special reference to heat cramps (myalgia thermica), by W.
L. Mann, passed assistant surgeon, United States Navy 380</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Detection of methyl alcohol, by C. Schaffer, hospital steward, United States
Navy 392</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">United States Naval Medical School laboratories:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the helminthological collection 395</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the pathological collection 395</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the miscellaneous collection 396</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Suggested devices: </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A bunk locker, a tray, and a bracket stool for use in sick bays and
wards of hospital ships, by E. M. Blackwell, surgeon, United States Navy 397</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A method for use in opsonic index work and vaccine standardization, by R.
E. Weaver, hospital steward, United States Navy 398</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Clinical notes:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A note on a case of fish poisoning in Guam, by W. M. Kerr, assistant
surgeon, United States Navy 401</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Two cases of climatic bubo, by E. W. Phillips, assistant surgeon,
United States Navy 402</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Rupture of the left kidney (nephrectomy), by A. M. Fauntleroy, surgeon,
United States Navy 404</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Abscess of the liver in a young infant, by F. E. Sellers, passed
assistant surgeon, United States Navy 405</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Appendectomy on a haemophiliac, by B. F. Jenness, passed assistant surgeon.
United States Navy 407</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Editorial comment: </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">New accounting system at naval hospitals, by Surg. Gen. C. F. Stokes, United
States Navy 411</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The relations of the American National Red Cross with the Medical
Department of the Navy in war 413</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Progress in medical sciences:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">General medicine. — Physical exercise and blood pressure. On the
identity of typhus fever and Brill's disease. Studies on the virus of typhus,
by A. W. Dunbar and J. L. Neilson 417</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Surgery.— The prevention and treatment of ventral hernia. Technique and
remote results of vascular anastomoses. Accidents and deaths from exploratory
puncture of the pleura. The control of bleeding in brain operations. Surgical
pathology of the stomach and duodenum, by R. Spear and C. M. Oman 421</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Hygiene and sanitation.— The physiological influence of ozone.
Influence of benzine, toluene, and light and heavy "benzines" on the
organism, by E. W. Brown. Disinfection experiments with perautan and paragan. A
new and rapid method of bacteriological water examination, its applicability to
the testing of filtered and well water. A mosquito larvacide disinfectant and
the methods of its standardization. The sterilization of milk bottles with
calcium hypochlorite. Apyrexial malaria carriers, by H. G. Beyer and O. N.
Kiske 431</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Tropical medicine. — Cell-inclusions in the blood of a case of
blackwater fever. The estimation of the specific gravity of the blood and its
value in the treatment of cholera, by E. R. Stitt 436</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Pathology and bacteriology.— A study of 35 strains of streptococci
isolated from samples of milk, by C. N. Fiske. Method for the quantitative determination
of fecal bacteria, by E. W. Brown. Pure cultivation of</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">spirochieta refringens, by M. E. Higgins 438</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Chemistry and pharmacy. —On the diagnostic value of colloidal nitrogen
in the urine in cases of carcinoma. Determination of the quantity of residual
urine. Clarification of the urine in the estimation of sugar. On the excretion
of formaldehyde, ammonia, and hexamethylenamine. Organic compounds of the
aromatic series as cholagogucs, by E. W. Brown and O. G. Ruge 439</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Eye, ear, nose, and throat. — An operation for glaucoma. Notes from an Indian
eye clinic. In the report from the St. Louis Ophthalmological Society in a
discussion on the antiseptic and germicidal properties of the silver salts.
Notes of three cases illustrating infection of the accessory sinuses by entry
of water into the nose during bathing. Three cases of chronic suppurative
otitis media, by G. B. Trible 441</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Reports and letters:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">An account of the sinking of the Japanese battleship Hatsuse in the
late Russo-Japanese war, by F. L. Pleadwell, surgeon, United States Navy.. 447</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Organization, camp management, and sanitation in effect at the marine barracks,
Camp Elliott, Isthmus Canal Zone, Panama, April 15, 1910, to February 26, 1912,
by S. D. Butler, major, United States Marine Corps.. 458</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Sanitary conditions in Samoa, by R. U. Reed, passed assistant surgeon, United
States Navy 462</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Sanitary conditions in Guam, by C. P. Kindleberger, surgeon, United
States Navy 464</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Number 4</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;"> </p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Preface v</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Special articles</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A description of recent hospital construction in the United States
Navy, by A. W. Dunbar, surgeon, United States Navy 473</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A few general principles of hospital construction, by F. W. Southworth,
S. B., architect 523</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Ventilation of warships, by R. H. Robinson, naval constructor, United States
Navy 529</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Plans and description of a hospital ship for the United States Navy, by
E. M. Blackwell, surgeon, United States Navy 539</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A report on the prevalence of framboesia (yaws) in Guam, and its
connection with the etiology of gangosa, by W. M. Kerr, assistant surgeon,
United States Navy 549</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Diagnosis and dosage in hookworm cases in the Navy, by J. F. Leys,
surgeon, United States Navy 552</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Nitrous oxide-oxygen anesthesia, by H. F. Strine, surgeon, United
States Navy 555</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A theoretical discussion of the character and genesis of thermic
myospasms, with further observations on myalgia thermica, by W. L. Mann, passed
assistant surgeon. United States Navy 558</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Eight hundred and twenty complement-fixation tests on 461 patients, by E.
P. Huff, passed assistant surgeon. United States Navy 562</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">United States Naval Medical School laboratories:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the helminthological collection 575</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the pathological collection 575</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Additions to the miscellaneous collection 575</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Suggested devices:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A simple method of securing shelf-bottle stoppers during target
practice, by H. S. Coombs, hospital apprentice, first class. United States
Navy. . . . 577</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The rat guard used in the Philippine Islands, by C. Fox, passed assistant
surgeon, United States Public Health Service 577</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Clinical notes:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Case reports from the United States naval hospital, Philadelphia, by G.
B. Crow, L. W. Johnson, A. J. Toulon, and C. W. Smith, passed assistant surgeons,
United States Navy 579</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A case of very large stone in kidney without acute symptoms.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Pneumonia following an injury.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">The effect of salvarsan on the average number of sick days from
syphilis.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A case of extensive adenocarcinoma.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">A case of exceptionally severe syphilitic Irido-cyclltis with marked
changes in the interior of the eye and total loss of light perception.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">An interesting case of gunshot wound, by J. M. Minter, passed assistant
surgeon, United States Navy<span> </span>584</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Fracture of humerus by muscular action, by R. G . Davis, assistant
surgeon, United States Navy 585</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Editorial comment :</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Participation of Medical Officers in Professional Conferences 587</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Sight tests for seamen 588</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Recent legislation affecting the Medical Department of the Navy 589</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Naval Hospital Corps 590</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Progress in medical sciences:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">General medicine. —Bier's hypersemic treatment in gonorrhceal epididymitis,
by C. N . Fiske. Normal human blood serum in obstetric practice. The cutaneous
reaction of syphilis. Clinical experience with neosalvarsan. By A. W. Dunbar
and J. L. Neilson 591</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Surgery. — Local anesthesia in traumatic surgery. Surgery of the bile
ducts. Vanadium steel bone plates and screws. Observations on the diagnosis of
renal tuberculosis, the indications for nephrectomy in its treatment, and the
technic of the operation. Pyloroplasty. By R. Spear and C. M. Oman 596</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Hygiene and sanitation. —Notes on the ventilation of troopships in the Tropics.
The structure and functions of the foot. By H. G. Beyer and C. N. Fiske 608</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Tropical medicine. — The antineuritic bases of vegetable origin in
relation to beriberi, with a method of isolation of torulin, the antineuritic
base of yeast, by J. L. Neilson 609</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Pathology and bacteriology. —Double-stain method for the polar bodies
of diphtheria bacilli, by O. G. Huge. The examination of diphtheria specimens;
a new technique in staining with toluidin blue. A critical</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">study of the organisms cultivated from the lesions of human leprosy,
with a consideration of their etiological significance. By M. E. Higgins 611</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Medical zoology. — Trypanosoma rhodesiense, a second species of
trypanosome producing sleeping sickness in man, by J. L. Neilson 612</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Chemistry and pharmacy.— Studies in bacterial metabolism, by C. N. Fiske.
The definition of normal urine. The estimation of indican in urine. A new
method for the determination of total nitrogen in urine.</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">On the determination of ammonia in urine. By E. W. Brown and O. G. Ruge
613</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Eye, ear, nose, and throat. —Tonsillectomy with consideration of its
complications. Protargol in antisepsis of the visual apparatus. The trachoma
question. Keratitis as a cause of myopia. By G. B. Trible 617</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Reports and letters:</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Fourth Provisional Regiment, United States Marines, Camp Thomas, North
Island, San Diego, Cal., by R. E. Hoyt, passed assistant surgeon, United States
Navy 623</p>
<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:normal;">Marine Expeditionary Force, Pekin, China, by R. B. Henry, assistant surgeon,
United States Navy 632</p>
If you have questions concerning reproductions, please contact the Contributing Library.
Note: The colors, contrast and appearance of these illustrations are unlikely to be true to life. They are derived from scanned images that have been enhanced for machine interpretation and have been altered from their originals.
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+++ DISCLAIMER +++
Nothing you see here is real, even though the conversion or the presented background story might be based historical facts. BEWARE!
Some Background:
The Lockheed F-94 Starfire was a first-generation jet aircraft of the United States Air Force. It was developed from the twin-seat Lockheed T-33 Shooting Star in the late 1940s as an all-weather, day/night interceptor.
The aircraft reached operational service in May 1950 with Air Defense Command, replacing the propeller-driven North American F-82 Twin Mustang in the all-weather interceptor role. The F-94 was the first operational USAF fighter equipped with an afterburner and was the first jet-powered all-weather fighter to enter combat during the Korean War in January 1953.
The initial production model was the F-94A, which entered operational service in May 1950. Its armament consisted of four 0.50 in (12.7 mm) M3 Browning machine guns mounted in the fuselage with the muzzles exiting under the radome. Two 165 US Gallon (1,204 litre) drop tanks, as carried by the F-80 and T-33, were carried on the wingtips. Alternatively, these could be replaced by a pair of 1,000 lb (454 kg) bombs under the wings, giving the aircraft a secondary fighter bomber capability. 109 were produced.
The subsequent F-94B, which entered service in January 1951, was outwardly virtually identical to the F-94A. The Allison J33 turbojet had a number of modifications made, though, which made it a very reliable engine. The pilot was provided with a more roomy cockpit and the canopy was replaced by a canopy with a bow frame in the center between the two crew members, as well as a new Instrument Landing System (ILS). 356 of these were built.
The following F-94C was extensively modified and initially designated F-97, but it was ultimately decided to treat it as a new version of the F-94. USAF interest was lukewarm, since aircraft technology developed at a fast pace in the Fifties, so Lockheed funded development themselves, converting two F-94B airframes to YF-94C prototypes for evaluation.
To improve performance, a completely new, much thinner wing was fitted, along with a swept tail surface. The J33 engine was replaced with a more powerful Pratt & Whitney J48, a license-built version of the afterburning Rolls-Royce Tay, which produced a dry thrust of 6,350 pounds-force (28.2 kN) and approximately 8,750 pounds-force (38.9 kN) with afterburning.
The fire control system was upgraded to the Hughes E-5 with an AN/APG-40 radar in a modified nose with an enlarged radome. The guns were removed and replaced with an all-rocket armament, which was – at that time – regarded as more effective against high-flying, subsonic bomber formations. The internal armament consisted of four flip-up panels in a ring around the nose, each containing six rockets. External pods on the wings augmented the offensive ordnance to 48 projectiles. Operational service began with six squadrons by May 1954.
According to test pilot Tony LeVier, the F-94C was capable of supersonic flight, but Lockheed felt that the straight wing limited the airframe's potential, esp. with the uprated engine. Besides, the earlier F-94 variants already saw the end of their relatively brief operational life, already being replaced in the mid-1950s by the Northrop F-89 Scorpion and North American F-86D Sabre interceptor aircraft in front-line service and relegated to National Guard service. Therefore, Lockheed launched another update program for the F-94 in 1953, again as a private venture.
The resulting F-94E (the F-94D was a proposed fighter bomber variant which made it to prototype staus) was another, evolutionary modification of the basic concept, which, in the meantime, had almost nothing left in common with its F-80/T-33 ancestry.
It was based on the F-94C, most obvious change was the introduction of swept wings for supersonic capability in level flight. This change also necessitated other aerodynamic adjustments, including a new, deeper fin with increased area and a modified landing gear that would better cope with the increased AUW.
Under the hood, the F-94E was constructed around the new Hughes MG-3 fire control system, similar to the early F-102, but kept the AN/APG-40, even though it was coupled with an enlarged antenna. The respective new radome now covered the complete nose cross section. Furthermore, the F-94 E introduced innovations like a Texas Instruments infrared search/tracking system (IRST), which allowed passive tracking of heat emissions, mounted in a canoe fairing under the nose, passive radar warning receivers, transponders as well as backup artificial horizons.
With this improved equipment the interceptor was now able to deploy semi-active radar homing GAR-1s and/or infrared GAR-2s (later re-designated AIM-4A/B Falcon), operating at day and night as well as under harsh weather conditions.
All missiles were carried externally on underwing pylons. Beside the original main wet hardpoints outside the landing gear (typically a pair of 165 US Gallon (1,204 litre) drop tank, that were carried on the wing tips on the former versions), two additional pairs of lighter pylons were added under the wing roots and the outer wings.
Typically, a pair of SARH- and IR-guided AIM-4s were carried, one per pylon, plus a pair of drop tanks. Alternatively, the F-94E could carry up to 4.000 lb (1,816 kg) of ordnance, including up to six streamlined pods, each holding nineteen 2 ¾” in (70 mm) Mk 4/Mk 40 Folding-Fin Aerial Rockets. Any internal armament was deleted.
The F-94E's new wings allowed a top speed of 687mph at sea level and a top speed of 693 mph (1,115 km/h) at height – compared with the F-94C’s 640 mph (556 kn, 1,030 km/h) a rather mild improvement. But the enlarged wing area resulted in a considerably improved rate of climb as well as good maneuverability at height. The F-94E's performance was overall on par with the F-86D, with the benefit of a second crew member, while its weapon capability was comparable with the much bigger (but slower) F-89.
Both of these types were already introduced, so the Air Force's interest was, once more, less than enthusiastic. Eventually the F-94's proven resilience to harsh climate conditions, esp. in the Far North, earned Lockheed in 1955 a production contract for 72 F-94Es for interceptor squadrons based in Alaska, New Foundland, Greenland and Iceland.
These production machines arrived to the Northern theatre of operations in summer 1956 and featured an improved weapon capability: on the wet wing hardpoints, a pair of MB-1 Genie (formerly known as ‘Ding Dong’ missile, later re-coded AIR-2) nuclear unguided rockets could be carried.
For the missile pylons under the wing roots, twin launch rails were introduced so that the F-94E could theoretically carry a total of up to eight AIM-4 missiles, even though the wet pylons were typically occupied with the drop tanks and only two pairs of AIM-4A and B were carried under the wing roots. The J48 engine was slightly uprated, too: the F-94E’s P-9 variant delivered now 6,650 lbf (29.5 kN) dry thrust and 10,640 lbf (47.3 kN) at full afterburner.
Keflavik Airport, Iceland, although controlled by Military Air Transport Service (MATS), was the first base to be equipped with F-94Es as part of the 82d Fighter-Interceptor Squadron in early 1957, where the machines replaced F-94Bs and F-89Cs.
The type was popular among the crews, because it coupled a relatively high agility (compared with the F-89 Scorpion) with the psychological benefit of a two men crew, not to be underestimated during operations in the Far North as well as over open water.
The F-94's career didn't last long, though, the aircraft soon became outdated. The last F-94E was already retired from USAF front-line service in November 1962, only three years after the last F-94C Starfires were phased out of ANG service. Eventually, the fighters were replaced by the F-101, F-102 and the F-106.
General characteristics:
Crew: 2
Length: 44 ft 11 in (13.71 m)
Wingspan: 39 ft 10 in (12.16 m)
Height: 14 ft 6 in (4.43 m)
Wing area: 313.4 sq ft (29.11 m²)
Empty weight: 12,708 lb (5,764 kg)
Loaded weight: 18,300 lb (8,300 kg)
Max. takeoff weight: 24,184 lb (10,970 kg)
Powerplant:
1× Pratt & Whitney J48-P-9 turbojet, rated at 6,650 lbf (29.5 kN) dry thrust
and 10,640 lbf (47.3 kN) at full afterburner.
Performance:
Maximum speed: 693 mph (1,115 km/h) at height and in level flight
Range: 805 mi (700 nmi, 1,300 km) in combat configuration with four AAMs and two drop tanks
Ferry range: 1,275 mi (1,100 nmi, 2,050 km)
Service ceiling: 51,400 ft (15,670 m)
Rate of climb: 12,150 ft/min (61.7 m/s)
Wing loading: 78.6 lb/ft² (384 kg/m²)
Thrust/weight: 0.48
Armament:
Six underwing pylons for a mix of AIM-4 Falcon AAMs (IR- and SARH-guided),
pods with unguided 19× 2.75” (70 mm) Mk 4/Mk 40 Folding-Fin Aerial Rockets,
a pair of 165 gal. drop tanks or a pair of unguided nuclear MB-1 Genie air-to-air missiles
The kit and its assembly:
Another entry for the Cold War GB at whatifmodelers.com. This build was originally inspired by profiles of a P-80/F-86 hybrid, and respective kitbashings from other modelers. An elegant, though fictional, aircraft! Nevertheless, I wanted to build one, too, and take the original idea a step further. So I chose the F-94 as an ingredient for the kit mix – a rather overlooked aircraft, and getting hands on a donation kit took some time, since there are not many options.
I wanted to use the F-94C as starting point, which is already considerably different from the F-80/T-33. Adding swept wings (from a Hobby Boss F-86F, with larger “6-3” wings) changed this look even more. So much that I decided to modify the fin, which did not look appropriate anymore.
The fin and the spine’s rear end was replaced with the fin of a Kangnam/Revell Yak-38. In order to unify shapes and make the donation less obvious, the Yak-38 fin’s characteristic, pointed tip was clipped and replaced by a more conventional design, scratched from a piece of 1.5mm styrene sheet. In the wake of this modification, the round elevator tips were clipped, too.
Using the F-94’s landing gear wells as benchmarks, the F-86 wings (which had to be cut off of the Hobby Boss kit’s integral, lower fuselage part) were sanded into shape and simply glued into a proper position.
This worked so well that a completely new and plausible main landing gear installation was created. As a consequence, I used the F-86’s landing gear struts - they are much better detailed than the Emhar F-94C’s parts. The front wheel strut (it’s a single piece) was transplanted too, even though the suspension was switched 180°.
The Emhar F-94C’s cockpit is pretty good (esp. the seats) and were taken OOB. I just covered some gaps in the cockpit walls and under the windscreen with paper tissue, soaked with white glue.
The nose was replaced by a bigger radome, taken from an Armstrong Whitworth Meteor NF.14 (Matchbox kit). Its diameter and shape fit almost perfectly onto the F-94C’s front end, and the result reminds a lot of the EF-94C photo reconnaissance test aircraft! Under the nose, a shallow fairing for the IR sensor was added, and all four air brakes were mounted in open position.
The underwing pylons come from the scrap box (one pair from an Airfix A-1 Skyraider, another from an ESCI Kamow Ka-34 ‘Hokum’ which also provide the launch rails for the ordnance). The drop tanks come probably from an Italeri F-16 (not certain) while the four AIM-4s come from a Hasegawa USAF air-to-air weapons set.
Painting and markings:
This was supposed to become a classic USAF aircraft of the late Fifties, since the F-94 had never been exported. I was actually tempted to add Red Stars, though, because the overall shape has a certain Soviet look to it - esp. the nose, which reminds a lot of the contemporary Yak-25 interceptor?
But the original USAF idea won, with an all-metal finish. In order to brighten things up I chose a squadron that served with the Northeast or Alaskan Air Command, which added orange-red high-viz markings to wings and fuselage.
The NMF sections were primed with a base coat of Revell’s acrylic Aluminum. On top of that, single panels and details were painted with Alu Plate and Steel Metallizer from Modelmaster.
The International Orange markings were created with Humbrol 132, slightly shaded with orange (Humbrol 18).
Part of the nose section and the spine were painted in ADC Grey (FS 16473, Modelmaster), just for some diversity. Cockpit interior and landing gear wells received a coat of US Cockpit Green (Humbrol 226), while the interior of the air brakes was painted in Zinc Primer (Humbrol 81), according to pictures of operational F-94s.
The landing gear struts and the inside of their covers became Aluminum (Humbrol 56). The anti glare panel in front of the cockpit was done with dark olive drab (Humbrol 66), the radome flat black and weathered with wet-in-wet streaks of sand brown.
Operational F-94s show serious weathering on their di-electric noses, so this detail was taken over to the kit. Other weathering with paint, beyond a basic black ink wash and some shading on the orange areas, was not done.
The drop tanks were painted with Steel Metallizer, for a different metallic shade from the fuselage, and the AIM-4’s received a typical outfit in white and bright red with different seeker heads.
Primary decals come from a Heller F-94B kit, which have the benefit of a silver background – even though this does not match 100% with the paint. Squadron markings come from an Xtradecal F-102 sheet, tailored to the kit. Most stencils come from the Emhar OOB sheet, plus some more from the aforementioned F-102 sheet.
After some soot stains around the exhaust were added with graphite, the kit was sealed under a coat of semi-glossy acrylic varnish. The anti glare panel and the radome were kept matt, though.
A pretty result. Mixing parts from a Shooting Star and a Sabre (a Shooting Sabre, perhaps?) results in a very elegant aircraft. And while the F-94 lost much of its original, elegant appeal, the combo still works with this later interceptor variant of the F-80. Very plausible, IMHO.
Front LED strobes & N/S locker. Both N/S & O/S lockers go right up to the bulkhead. Just need to decide wether to take out the back fuel tank next and put some thing in its place prehaps a spare wheel tray or underbox, mmmmm!!!
This church on Warwick Road in Acocks Green is St Mary the Virgin. It is the Parish Church of Acocks Green.
It is a Grade II listed building, since July 2009, possibly to help it with renovations (can't find listing on Heritage Gateway but it is on the Acocks Green History Society's website).
997/0/10468 WARWICK ROAD
23-JUL-09 Acocks Green
Anglican Church of St Mary the Virgin
II
An Anglican parish church in broadly C13 style, designed by J G Bland, dating from 1864-1882 with extensions of 1891-4 by J A Chatwin.
MATERIALS: The church is constructed from two colours of local sandstone, apart from red brick walls to the exterior of the transept arches marking the impact of WWII bombing; the roofs of the main church are of concrete tile, and those of the east ends of the aisles are of slate.
PLAN: The church is orientated north east-south west, though ritual compass points are used throughout this description. The plan has nave, north and south aisles, chancel, north vestry, south organ chamber and north porch.
EXTERIOR: The exterior is of red sandstone with cream sandstone dressings. The long elevations have five bays to the clerestoried nave, and a slightly lower two-bay chancel. The westernmost nave bays have aisle windows of three lights below clusters of trefoils, set into pointed archways with colonnettes with carved capitals including foliage and human heads. The clerestory windows above are paired plain lancets. In place of the transepts are continuations of the aisle in brick, with four lancets. The north porch has a steeply-gabled roof and elaborate Early English doorway with zig-zag and foliate decoration. The north vestry is also gabled, and has a further lean-to vestry with similar windows to those in the nave. The south side is similar but has a flush doorway instead of a porch in the western bay, and a C20 brick extension at the east end. The north and south sides of the chancel each have two tall two-light windows with trefoils above, running full height. The west end has a tall window of paired lancets with cusped decoration and a circular window above, with carved foliate decoration to the spandrels, and a drip mould with zig-zag decoration. Below this is a blind arcade of eight pointed arches carried on colonnettes with composite capitals and a continuous drip mould with zig-zag carving. The east window has Decorated tracery, giving five tall lights, quatrefoils and cinqefoils, and glazed spandrels.
INTERIOR: The interior has whitewashed brick walls above stone arcades. The five-bay arcades are of pointed arches in bands of red and cream sandstone, which spring from short, round piers carried on very high bases, with carved foliate capitals. The nave has an arch-braced collar-rafter roof whose trusses are carried on moulded stone corbels; the chancel roof is a timber barrel vault. The floor of the aisles is of large stone flags, and that to the east end is in polychrome tile. The westernmost bay is screened from the main body of the church by a pierced timber screen. The pews, which, like most of the furnishings were lost in the bombing of the church, have been replaced with chairs. The chancel arch and transept arches spring from slender clustered columns with foliate capitals carved by Bridgman of Lichfield. The interior of the church is dominated by the sumptuous east end. The chancel windows have red and cream banded stone surrounds, and those to the north and south sides are divided by full-height, slender clusters of columns rising to foliate capitals which serve as corbels for the trusses of the roof. A high and elaborate carved alabaster reredos, made in 1903, again by Bridgman of Lichfield, depicts Christ in Majesty, flanked by angels carrying the symbols of the Passion. Matching panels with statues of the Archangels in canopied niches are set to either side of the reredos, and the alabaster carvings are carried around the returns. Above the reredos, in a Decorated window, is a stained glass window from designs by Burne-Jones and Philip Webb, depicting the Crucifixion. The timber altar has painted angels in Pre-Raphaelite style. The altarpiece is carved from Devonshire marble, and has niches to either end housing figures of angels. The font and other furnishings date from after the church's restoration in the 1950s, including a polygonal timber pulpit with canopy by P B Chatwin.
SUBSIDIARY FEATURES: The church has a LYCH GATE in the west boundary wall of the plot. This has a buttressed sandstone base with a timber superstructure, under a hipped roof with slate covering, surmounted by a cream-coloured terracotta cross. Timber gates are mounted in the gateway.
HISTORY: The Church of St Mary the Virgin was begun in 1864, to designs by J G Bland, as a chapel of ease to St Eadburgha's in Yardley. The building, consisting of part of the nave, north and south aisles and north porch, was intended to have transepts, chancel, vestries and a south-west tower added at a later date. Subsequent phases of building were dependent on donations, and progressed slowly. The church was consecrated in 1866, and a parish was created in 1867, out of part of the parish of St Eadburgha. In 1878, work to complete the nave began, with the addition of transept arches and chancel arch. From 1891-2, the church was further enlarged, by J A Chatwin, who added the chancel, organ chamber and vestries; the work was not completed until 1894. A stained glass window by Morris and Co to designs by Burne-Jones was added in 1895, in memory of Reverend Frederick Thomas Swinburn, late Vicar of Acock's Green; it was paid for by his widow. Further stained glass was installed by various other benefactors, including a large west window by Hardman and Co. In 1903, an elaborate alabaster reredos, carved by Bridgman of Lichfield, was added to the east end.
In 1940, the church suffered a direct hit from a large incendiary bomb, which landed at the crossing. The church was badly damaged, with the loss of the roofs, internal furnishings, and most of the stained glass and other decoration. Remarkably, the west window and reredos survived with only minute damage, and the arcades were very little damaged, with the structure remaining sound. The church was repaired, with some modifications, during the 1950s: the steeply-pitched roof was replaced with a shallower roof, and the height of the clerestory increased; the circular clerestory windows were replaced with taller, rectangular windows. New furnishings were donated, including a new font, pulpit and west screen. The transepts and tower were never built.
SOURCES: Carew-Cox, A and Waters, W: Edward Burne-Jones - Stained Glass in Birmingham Churches (1998)
Pevsner, N and Wedgwood, A: The Buildings of England: Warwickshire (1966), 143-4
History of the County of Warwick (Victoria County History), Volume 7: City of Birmingham (1964), 391
REASONS FOR DESIGNATION: The Anglican Church of St Mary the Virgin is designated at Grade II, for the following principal reasons:
* The original church was a lively composition of 1865 by a recognised regional architect, J G Bland
* This was enhanced by additions by J A Chatwin, the prolific West Midlands church architect, in the 1890s
* Although the church was badly damaged by enemy action in 1940, and the proposed tower and transepts were never added, the church as it stands retains much historic fabric of good quality, and was fully restored in the 1950s
* The damage and losses (of some interest in their own right, for showing the impact of the 1940 Blitz) are outweighed by the survival of the sumptuous and high-quality carved alabaster reredos, and the large stained glass east window, made by Morris and Co from designs by Sir Edward Coley Burne-Jones.
This is a major modification of a stock Aoshima PA-36K “Berlon” kit – redesigned almost beyond recognition ;). In fact, the victim of my modifications was the second “spare” kit included in the kit box, and it found good and creative use.
I will tell a bit of the story behind this kit, because idea and inspiration evolved step by step over a longer course of time.
It all started with the idea of applying a stylish “state of the art” fractal camouflage scheme on a Dorvack Powered Armour. Considering colours and such a paint scheme’s purpose to break up an objects outlines, I remembered the so-called “Hinterhalt” (“Ambush”) scheme of German WWII military vehicles around 1943-1944: a scheme of 3 high contrast colors (RAL 7028 “Dunkelgelb”/”Dark Yellow”, RAL 6003 “Olivgruen”/”Olive Green” and RAL 8017 “Schokoladenbraun”/”Chocolate Brown” or RAL 8021, actually a rust primer).
The pattern of these basic colors was improvised in the field – with the result that many tanks did not look alike. You can find many different and even creative versions of the 3 basic colours, with stripes and mottles. Its design purpose was to conceal vehicles in forests, from above, mainly in mid Europe where air superiority faded.
This historic pattern has already found its way on some PAs I found in the internet, it is a classic. My idea was then to take the basic colors and follow the basic scheme idea, but apply it in a “digital” fashion, in a kind of grid that would effectively break up any outline.
At that time I considered a standard PA like a PA-58 as a kit basis, since I just followed the paint scheme idea at that time. And this camouflage idea got even more fuel when I saw parts of the Dorvack TV series in the internet – in some scenes (e. g. in episode 14), Powered Armours with a disruptive 3 tone camouflage scheme (I'd say a medium olive green, a very light grey-green and a sand tone with a very pink hue…) or in overall bronze green livery appear. So, camouflage on such a kit was not total fiction.
You might check here for reference:
Dorvack TV series - stills from Ep. 14 & 18 auf Yahoo! Video
Anyway, with the WWII inspiration, I stumbled across a certain vehicle while reading reference literature – the German “Sturmtiger” tank. It was an assault version of the famous Tiger tank, only 78 were re-built from damaged chassis. The turret was replaced by a heavily armoured “box” and a 38cm(!) rocket mortar was built into the tank’s front – actually a weapon which had been developed for the German navy. The Sturmtiger’s main purpose was to crack heavy fortifications like bunkers and to support soldiers in urban combat with building-wrecking firepower.
Bringing it all together, it clicked: I wanted to create a cross-breed between a Dorvack PA and a Sturmtiger tank – or, at least, bring both “spirits” together – and paint it with a weird camouflage scheme!
Here, a spare PA-36K “Berlon” kit came into play. The original kit from the box still waits for assembly, and since #2 comes without decals and its bigger arms’ and legs’ parts would make the figure appear more massive and “edgy” than a standard PA-36 “Nove”, this became an ideal basis.
The kit itself underwent major modification, e .g. the head/helmet with the visor front. Here, American locomotives like the Baldwin „Shark Nose“ diesel locomotive were an inspiration. The original round front/top of the basic PA-36 kit was replaced - besides lots of Tamiya 2C putty, the cockpit area of a 1:144 F-117 kit went into it! The former clear cockpit canopy now houses a new visor arrangement, and the broad and edgy new outline gives the PA-36 a totally different look, much like the PA-48Z "Paladin" conversion kit vs. its PA-48 "Guardian" base.
Another custom piece is the kit’s armament. Taking up the Sturmtiger idea and its characteristic mortar, I built a massive forearm gun from Dorvack spare parts and scratch. The basis is a reversed R6 cannon (the hand-held gun that comes with the standard blue PA-36N kit), its cannon muzzle actually is an A-10A’s engine exhaust in 1:72! Inside, a barrel was added as well as a characteristic exhaust ring (an engine part from a Matchbox 1:72 PB4Y -2Privateer) that creates a similar look like the Sturmtiger’s 38cm assault mortar’s mouthpiece.
Thinking the urban combat/assault task further through, I felt that this assault PA needed another weapon. Smoke dischargers for defence were already part of my plan, but just like in real life (like the German heavily armoured assault tanks in WWII), this PA lacked short range firepower at close range and against soft targets.
It had to be a gun, no further missiles, and so I salvaged a “CW-27 Gatling Smash” gun from a PA-58N kit – a 3 barrelled gatling gun with a drum magazine that is a 2 handed heavy weapon for the small PA-58, but a medium gun for the bulky PA-36 base.
The gatling gun was modified to hold a belted cartridge feed system with a corresponding magazine on the PA’s back (which made a new exhaust system for the jump jets necessary...). The gun itself was modified to be mounted on the PA’s left forearm, which offers – thanks to the different PA-36K’s parts – an even and credible basis to hold the massive gun.
All in all, the PA looks very intimidating with all this equipment – Idelians beware!
Finally the painting: I wanted to stay close to the German original colors. But even though some of the authentic tones are available, I slightly varied them for the kit:
• The RAL 7028 Dark Yellow became Humbrol 94 (“Brown Yellow”). Actually, it is IMHO a good approximation to the WWII RAL colour. Anyway, there were no colour samples left after the war, and nobody knows for sure what this tone actually looked like! As a side note: anything you see today on kits or in museums is just guesswork.
• I replaced RAL 6003 Green (very similar to FS 34102) with an FS tone I found from Testors: FS 34096, an obscure green/olive drab which had been used on B-52 bombers. It contains less yellow than both RAL 6003 and FS 34102 and yields a lighter, almost sun-bleached and worn look.
• RAL 8021 is actually available from Humbrol (tone 160). But again, I settled for a lighter colour with Humbrol 186 (“Brown”).
The colours were applied with a flat 4mm brush in rectangular “blocks”, so that each tone got a third share on the surface.
In a second step, the colour boundaries were frazzled and fractal “mottles” were added all over the kit – a time-consuming job, but the effect is stunning. I copied the fashion in which the original colors were applied: green on sand, and the sand on green and brown, so that the color shares become about 40% sand, 35% green and 25% brown.
Altogether, the overall look and impression of the “Hinterhalt” scheme was kept, despite the fractal scheme, and the kit looks less dark and murky.
Some typical PA details like the chest box were painted in orange - mainly because the water sliding decals (from various kits, including a Dougram Round Facer in 1:72) were orange, too.
Finally, the whole kit received a black ink wash and some weathering through dry painting in hemp and some silver, and finally a matte overall cote.
Pictures were taken with a simple Kodak CX 7330 digital pocket camera.
A building at the corner of Main and South Streets in Beacon, NY that's seen some modifications over the years.
Another Matchbox Series No4 Dodge K Series Stake Bed Truck Modification. 1966 to 1968 - 1-75 Series my second restoration of a stake bed. I like this color and I think it shows pretty good in the photos. Here it is as a bob tail, I like how it looks. What to add?
Ferry deck's layout, modifications, discussion below on changes...
SS Badger Carferry
Manitowoc Wisconsin
Modification of the Oliver + S free pattern.
More here: bartacksandsingletrack.blogspot.com.au/2015/12/a-million-...
and tutorial here: oliverands.com/community/blog/2015/12/customizing-the-ons...