View allAll Photos Tagged LED
www.msn.com/en-us/money/markets/fda-lays-out-annual-covid...
FDA Lays Out Annual Covid Shot Plan Similar to Flu
(Bloomberg) -- Americans are about to get a clearer idea of how often they’ll roll up their sleeves for Covid-19 shots when advisers to US regulators meet Thursday to discuss an immunization schedule that looks more like the one used for flu.
The plan would have health officials meet each June to review which strains of the virus should be included in Covid shots to be deployed no later than September of the same year, according to documents released by the US Food and Drug Administration ahead of the Jan. 26 meeting.
Experts from around the world convene annually to make predictions about which flu strains will dominate during the upcoming season and, thus, should be targeted by shots. The FDA is looking for a similar coordinated effort to take place at least as often for Covid shots, one of several changes the agency hopes might help simplify the immunization process and encourage more Americans to stay up to date.
Waning immunity from vaccinations and the emergence of new variants every few months has led regulators to recommend variant-targeted boosters, a tactic that so far has been unpopular among Americans and has even split some health experts on costs and benefits. Just weeks after rolling out the updated BA.4 and BA.5 boosters in September, new mutations were rampant. Now, even as the US sees the rise of an immune-evasive variant called XBB.1.5, booster uptake is hovering at about 15%.
“Although the use of the bivalent mRNA boosters is supported by the available evidence, their deployment has been associated with significant implementation complexities,” the FDA said. Switching to one composition for both primary shots and boosters will help streamline the process, according to the agency documents.
Evidence suggests that immunity from prior exposure to the virus along with vaccination will provide enough protection so that most people will need one annual Covid booster, according to the documents. However, young children who might not have been previously exposed and people who are at higher risk for severe disease may need two yearly shots, the FDA said.
“An annual vaccine would be ideal because people would remember, they can do it with other vaccinations like flu and it can last,” Albert Bourla, chief executive officer of Covid vaccine-maker Pfizer Inc., said Jan. 18 in an interview with Bloomberg.
The FDA is still concerned about evasion of vaccine-induced immunity by mutants of the fast-spreading omicron strain, according to the documents. That warrants continued surveillance of variants and also monitoring of the protection previous vaccines provide against new strains.
Pfizer and Moderna Inc. are both working on next-generation vaccines that hold up against mutations and provide longer-lasting protection, but it’s unlikely those will be ready to go into arms anytime soon.
www.news-medical.net/news/20230123/SARS-CoV-2-Omicron-XBB...
SARS-CoV-2 Omicron XBB.1.5, CA.3.1, and CH.1.1 exhibit remarkable antibody resistance
In a recent study posted to bioRxiv* preprint server, researchers at Ohio State University examined the degree of neutralizing antibody (nAb) evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB.1.5, CA.3.1, and CH.1.1 subvariants.
Several subvariants have emerged from SARS-CoV-2 Omicron, some showing relatively higher immune evasion, threatening vaccination efficacy. The BQ.1.1 sub-variant was the most prevalent following months of BA.5 predominance in the United States. Nonetheless, it is being quickly replaced by XBB.1.5. The XBB lineage was first detected in India as a recombinant of BA.2.75 and BA.2.10.1.1. Its emergence was alarming since it contained numerous mutations with established immune escape characteristics.
The effectiveness of monoclonal antibodies (mAbs), mono- or bivalent vaccines, and infection-induced immunity were reduced against XBB. The XBB lineage acquired two additional substitutions in the spike, resulting in XBB.1 and XBB.1.5 subvariants, and their impact remains unknown. In addition, the CA.3.1 and CH.1.1 subvariants of Omicron have been notable lately, as they carry the L452R substitution in the spike, previously discovered in the Delta and Omicron BA.4/5 variants.
The study and findings
In the present study, researchers evaluated the spike protein biology of emergent SARS-CoV-2 Omicron subvariants XBB.1.5, CA.3.1, and CH.1.1. First, they assessed the infectivity of spike-pseudotyped lentiviruses in HEK293T-ACE2 cells expressing human angiotensin-converting enzyme 2 (ACE2) and Calu-3 cell line. XBB.1 and XBB.1.5 had higher infectivity, with nearly two-fold increased titers than SARS-CoV-2 D614G in HEK293T-ACE2 cells.
XBB subvariants’ infectivity was not significantly different from that of D614G in this cell line. By contrast, CA.3.1 and CH.1.1 subvariants had nearly 2.5-fold lower infectivity than D614G in Calu-3. Next, the team tested neutralization of these emergent subvariants by sera from 14 healthcare workers (HCWs) boosted with a bivalent vaccine after two-to-four doses of monovalent mRNA vaccine.
Sera were obtained after a median of 66 days post-bivalent vaccination. CA.3.1, CH.1.1, and XBB.1.5 subvariants showed strong resistance to neutralization by sera relative to BA.4/5, with 4.6 to 17.7 times lower nAb titers than BA.4/5. Interestingly, XBB.1.5 had slightly higher nAb titers than its parent lineage (XBB).
Of note, BQ.1.1 showed higher neutralization resistance than any of the XBB subvariants, with 12.8 lower nAb titers than BA.4/5. The CA.3.1 and CH.1.1 subvariants displayed much higher resistance to neutralization by bivalent sera. Next, the neutralization experiments were repeated using sera from HCWs vaccinated thrice with monovalent mRNA vaccines.
Samples were obtained after 2-13 weeks post-vaccination. The mean nAb titers of triple-vaccinated sera against SARS-CoV-2 D614 and Omicron (BA.2 and BA.4/5) were up to 5.6-fold lower than those of bivalent sera. nAb titers were markedly reduced for CA.3.1, CH.1.1, and XBB.1.5 subvariants. Overall, the trends of triple-vaccinated sera in neutralizing subvariants were comparable to those of bivalent sera.
In addition, the team examined the neutralization resistance of subvariants to sera from individuals infected with BA.4/5. They observed potent and near-complete neutralization resistance for CA.3.1, CH.1.1, and XBB.1.1 subvariants, with 2.6 to 4.1-fold lower nAb titers than BA.4/5. Furthermore, the researchers determined fusogenicity, surface expression, and processing of spike proteins of the subvariants.
Reduced syncytia formation was evident for all subvariants relative to D614G. XBB.1 and XBB.1.5 showed no differences in spike fusogenicity compared to XBB. The efficiency of syncytia formation of CA.3.1 and CH.1.1 was lower than BA.2.75.2. XBB subvariants, BQ.1.1, and BA.2.75.2 exhibited higher spike processing than D614G. There were no differences in spike processing for CA.3.1 and CH.1.1 subvariants relative to the parental BA.2.75.2.
Finally, homology modeling of XBB lineage spikes complexed with ACE2 or nAbs was performed. The P486 residue in XBB.1.5 was more hydrophobic than the S486 residue in XBB/XBB.1, resulting in favorable interactions with residues in ACE2, which allows better receptor utilization. The residue 486 is a hotspot for class I nAb recognition, and mutations at this site in XBB subvariants completely abolish interactions with the therapeutic mAb, AZD8895. Mutations at K444 and L452 residues found in CA.3.1 and CH.1.1 also affect interactions with class II nAbs.
Conclusions
Taken together, the findings suggested that bivalent mRNA vaccines induce up to eight times higher nAbs than monovalent vaccines. XBB subvariants, CA.3.1 and CH.1.1, exhibited almost complete escape from neutralization by triple-vaccinated or BA.4/5 infection sera. Moreover, XBB.1.5 did not show enhanced immune evasion relative to BQ.1.1. CA.3.1 and CH.1.1 subvariants consistently showed higher resistance to neutralization than XBB subvariants, warranting continued surveillance and further analyses.
My photo walk of March 7, 2023 along the left bank of the Saône between l'Ile Barbe and the Quai Gillet, Lyon, France.
I used my recently arrived Rollei 35 camera (year 1973) and a Rollei Retro 400S (=Agfa Aviphot) 36-exposure film exposed for 400 ISO.
The Rollei 400S - Agfa Aviphot film used for aerial photography is specially sensitized in the red, up to 780nm in the near IR instead of the regular 650-680 nm limit of a normal panchromatic film. The film provides usually high-definition and high-contrast negative views. What is more, the Agfa Aviphot is coated on a thin and flat polyester base without any base color increasing the contrast as well. However to prevent the halation possible the Agfa Aviphot is coated on the backside with a black and blue anti-halation pigment to inhibit the light back diffusion (halation).
Expositions were determined using a Minolta Autometer III with a 10° finder for selective measurements privileging the shadow areas. Measuring was found consistent with the Rollei 35 build-in photometer when oriented to the zone of interest. Typically, 1/250s, was used at f/8-f/5.6 to f/3.5. Allthe vi ew were taken with a 24mm screwed Rollei filter anti-UV fitted on the Tessar 1:35 f=40mm lens with the original Rollei neoprene shade-hood.
Quai Georges Clémenceau, March 7, 2023
69300 Caluire-et-Cuire
France
After exposure, the film was processed using Adox Adonal (=Agfa Rodinal R09) developer at dilution 1+25, 20°C for 10 min 30s.
The film was then digitalized using a Sony A7 body adapted to a Minolta Auto Bellows III and a Minolta Slide Duplicator using a lens Minolta Bellow Macro Rokkor 50mm f/3.5 at a reproduction ratio of 1:1. The reproduced RAW files obtained were processed in LR prior the the final JPEG editions.
All views of the film are presented in the dedicated album either in the printed framed versions and unframed full-size jpeg.
About the camera and the lens:
This original Rollei 35 is equipped of the collapsible 40mm Tessar lens "Made by Rollei" under Carl Zeiss licence who designed the first 1:3.5 f=40mm Tessar lens for the Rollei 35. Original Rollei 35 were manufactured by Rollei Franke & Heideke company originally in Germany starting year 1966 then later in Singapore until 1981. Originally, the build-in CdS cell was design by Gossen and the central shutter by Compur. Diaphragm and shutter are operated mechanically by two wheels on the front of the camera. The CdS cell is coupled to both. The Rollei 35 was a miniature 35 mm camera weighting around 320g, about 100g more than the Rollei 35 LED for instance with less mechanical parts. Overall more than 2 millions of Rollei 35 camera were produced over 15 years under different versions. According the serial number (3 410 XXX) of this chrome-plated camera was produced by Rollei Singapore between 01/1971 and 06/1973 and likely after 04/1973 due to the Tessar lens "Made by Rollei" instead of formally Carl Zeiss Tessar (ref : rollei35.eu/rollei35numbers.php#r35ge). It came with its original leather pouch, the wrist strap, a Rollei soft collapsible shade hood, Rollei 24mm screw-on UV and medium yellow filters, and the original user manual.
DSLR Flycam, Canon 60D, Led video light на съемке ролика о жонглировании. Производство - Шибанов Андрей, аренда DSLR Flycam, Canon 60D, Led video light - cinemakit.ru
Houdini è la serie di lampade che oltre all'illuminazione produce sorpresa perché sembra non usare alcuna fonte luminosa.
E' la magia creata dalle centinaia di led (480 nel modello a sospensione) nascosti in soli 8 millimetri d'intercapedine. Tutto si gioca tra il paralume esterno, in alluminio verniciato, e il diffusore interno, in metacrilato bianco. Una volta accesa, il diffusore s'illumina e... stupisce l'osservatore.
Die Stromabnahme an vier Rädern. Mehr dazu findet sich in diesem Album: www.flickr.com/photos/14005159@N00/sets/72157629807529389/
As nossas luminárias são produzidas em acrílico com gravação laser + base em acrílico tipo sanduíche com luzes de LED.
My daughter bought an electric fan which has LED lights on it. As soon as I saw it I knew I'd have to take some night shots of it!
LEDs van een chemiluminescente en fluorescente imager op mijn werk (lab).
Diagonale uitsnede leek me interessanter dan horizontaal/verticaal.
Kleuren van de LEDs zijn echt!
Licht bewerkt (ruis,contrast)
Spout – this is what makes kitchen faucets so. That spout can clearly tell the difference between the kitchen faucet, and, say, bath mixer. Typically, spout Kitchen Faucets are high enough (for the convenience of washing up) and have a swivel mechanism allowing a stream of water exactly where it is needed. Distinguished by the type cast (seamless) and composite (made up of several parts) mixers. And she, and other technologies have their advantages, therefore, choosing faucets for the kitchen, do not make this a major factor in the assessment.
Free Shipping Faucets Here : www.FaucetSuperDeal.com
led litec is a manufacturer of high technology led lighting and light emitting diode bulbs, tubes, corn lights, indoor and outdoor lights, industrial & commercial lighting, strip lights, ropes and led neon tubes. www.ledlitec.com
Perspectives Charter Schools conducted a Chicago Ideas Week Lab introducing the schools’ A Disciplined Life® (ADL) education model to the general public, and teaching them how to apply social emotional learning (SEL) in their own lives.
Students led up to 50 participants in an ADL class on Thursday, October 16 from 9 a.m. to noon at the Perspectives Rodney D. Joslin campus, 1930 S. Archer Ave. Participants engaged in rigorous discussion and self-reflection like Perspectives students do every day.
A Disciplined Life is a toolbox that teaches students how to be their best selves, cultivate healthy relationships, make informed decisions and become ethical, conscientious leaders. The curriculum was developed by Perspectives’ founders Diana Shulla-Cose, president of Perspectives, and Kim Day, the chief education officer.
“People will come away with a better understanding of social emotional learning and what students in inner-city schools are capable of,” said Rhonda Hopps, Perspectives’ chief executive officer. “We will inspire them to practice the 26 principles of A Disciplined Life to raise their level of fulfillment and civic engagement to drive positive social change.”
For one week, October 13-19, Chicago Ideas Week brings together some of the world’s most outstanding thinkers, inventors, leaders and creators to present their ideas and inspire the innovations of tomorrow. It is a platform based on sharing big ideas and making big things happen. Perspectives students make no small plans. Last June, student leaders organized a peace march down State Street on the South Side to express their hopes for a violence-free summer. More than 2,000 Perspectives students were joined by business and civic leaders, and the event was covered by some 30 media outlets.
Chicago Ideas Week Labs give people a chance to explore the best of Chicago, through exclusive access, behind-the-scenes experiences that give them a glimpse of the inner workings of businesses and institutions that are otherwise unavailable to the public.
Hopps, Shulla-Cose and Day will be in attendance during the lab.
Founded in 1997 by two public school teachers, Perspectives Charter Schools is a network of five open-enrollment public schools on the South Side, serving nearly 2,200 students. Perspectives prepares students for college and for life with its A Disciplined Life® education model that combines academic rigor with a focus on character development. Despite coming from some of the most disadvantaged neighborhoods in Chicago, Perspectives students graduate from high school, enroll in college, and persist towards graduation at rates above the national average. Learn more at pcsedu.org.
About Chicago Ideas Week
Chicago Ideas Week (CIW) is a 501(c)(3) organization. CIW is a premier year-round gathering of thought leaders created to drive ideas into actionable results. It is a platform for ideas, created for innovators, thinkers, doers and interested citizens from across Chicago, the greater Midwest and the world. Its goal is to stimulate new initiatives and ventures, create new connections and collaborations, and establish a community of curiosity. For more information, please visit www.chicagoideas.com and follow Chicago Ideas on Facebook and Twitter via @chicagoideas.
Photo credit: Jason Brown Photography
Horloge : Eclipse
A la recherche de nouvelles expressions du temps,
Alainpers a créé cette horloge où deux disques se superposent.
L’un en verre, l’autre en bois et le temps-lumière entre les deux.
Principe :
la seconde tourne autour du disque de verre entraînant à chaque tour les minutes.
Les heures sont indiquées en clair.
Caractéristiques techniques :
Graphisme du disque de verre réalisé par sablage et
chiffres argentés.
La lumière est produite par des diodes électroluminescentes ambres.
Le bois est un plaquage de type "APLIKORD".
40 cm de diamètre.
_________________________
Clock : eclipse
In search of new expressions of time, Alainpers created this clock where two disks overlap.
The one glass, the other one wooden and the time - light between both.
Principle:
the second turns around the glass disk entailing in every tour the minutes.
The hours are indicated in number.
Graphicsof the disk of glass realized by sanding and silvery figures.
The light is produced by amber
light-emitting diodes.
The wood is a veneer of type
" APLIKORD ".
Dimensions: 40 cm in diameter.
Apologies for the poor picture. Seen here are LED reading/display lamps on board Erode WAP 4 #22268 (newly painted with new fonts). The older P4’s seem to be going through a sea of changes after their POH. This seems to be one of the many different features added. Also some older P4’s in the 222xx series have now been fitted with yellow high speed pantos instead of their regular ones.
led litec is a manufacturer of high technology led lighting and light emitting diode bulbs, tubes, corn lights, indoor and outdoor lights, industrial & commercial lighting, strip lights, ropes and led neon tubes. www.ledlitec.com
Based on: www.dealextreme.com/details.dx/sku.4530 and the brilliant fnordlicht constant current source: www.lochraster.org/fnordlicht/
I'm a chargin mah lazzzzzor...