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We baked cookies to replicate the Settlers of Catan board game. Gumdrops and pieces of gumdrops were cities and settlements, respectively. Colored icing-covered pretzel sticks were roads. Wheat was meant to be lemon zest sticking up, but they fell flat. Ore was a big black gumdrop mountain with chocolate-covered cacao nib ore nuggets. Brick was raspberry jam with white icing mortar lines. Sheep was green coconut with little sheep carved from marshmallows. Forest was a stack of pretzel sticks for lumber, with one standing tree (basil seedling leaves atop pretzel stick trunk). Desert was cinnamon sugar. The robber was meant to be shaped like the piece, but flopped over so we stuck a parasol in him to make it easy to see.
The right hand side and middle are my lines. The left hand side is the original pinstriping, which I had to copy over to the right, as well as the lettering.
Genome dynamics and stability are the ne plus ultra requirements for cellular life. No matter whether life began with metabolism, with self-replicating genetic molecules, or as a cooperative chemical phenomenon, all cells and viruses maintain a genome capable of multiplication, variation and heredity. A population of living entities with these properties will evolve by natural selection, and while modern metabolism supplies the monomers from which genomes (i.e. replicators) are made, genomes alter the kinds of chemical reactions occurring in metabolism (Maynard Smith and Szathmary 1997). This book deals with DNA repair and replication. Together with two other planned volumes,one on transposable elements and genome dynamics and another on recombination and meiosis as a key issue of the metazoan germline development, this volume introduces the conceptual frame work of the series. An earlier review on the classic monograph Mobile DNA (Berg and Howe 1989) was entitled“On the Impossibility of Knowing More. ”It states:“This big book indeed tells us everything but says nothing. It provides no conceptual framework as to what the burgeoning bulk of molecular data means, not out of intent but because it is swept along by an attitude found increasingly in science of ‘never mind the quality, feel the width’ ... the book is essentially uninformative regarding the biological importance of transposable elements in ontogeny and phylogeny” (Dover 1990). The present book series tries to circumvent such criticism. Of course, there have been milder opinions of the monumental Mobile DNA book as well (Brookfield 1989; Fincham 1989). Actually, the 2002 publication of its successor Mobile DNA II (Craig et al. 2002) impressively demonstrates the swift progress int his significant research field, which now not only largely addresses questions of evolutionary relevance but pragmatically feeds additional knowledge applied in human gene therapy or helps to understand the somatic maturation of the immune system by V(D)J recombination. The latter actually demonstrates the closeness of transposable element transposition to DNA repair as the V(D)J recombination reaction is completed by the non-homologous end joining (NHEJ) DNA repair pathway in lymphocyte development where the DNA double-strand break (DSB) is generated through the transposase (i.e. endonuclease) activity of an ancient transposable element. This transposon inserted into an ancestral vertebrate genome some 450 million years ago(Yuetal.1999). In line with this important interface between a vertebrate transposon and DSB repair, the second chapter of Part II of this book reports on asimilar relationship of the Drosophila P elements triggering DSBs and facilitating the understanding of the mechanisms of replication-dependent DSB repair. Other molecularly fossilized but experimentally revitalized transposable elements which promise to be o fbiomedical relevance are planned for an upcoming book volume. As Carl Woese recently said, it seems to be about time that biology makes a choice between the comfortable path of continuing to follow molecular biology’s lead or the more refreshing one seeking a new and inspiring vision of the living world (Woese 2004). To accomplish this is my goal with the book series Genome Dynamics and Stability, where this first volume is dedicated to integrative aspects of replication and DNA repair providing an overview of some facets and perspectives of genome integrity. DNA integrity is relevant for all organisms, and therefore it opens avenues of curiosity ranging from viroids in applied plant research to grasping biodiversity. This vision however must include pragmatic aspects of biomedical relevance as well. The book at hand is entitled Genome Integrity: Facets and Perspectives. It contains a rather broad spectrum of chapters representing key aspects of DNA repair with a slight bias towards DSB repair as justified by its importance. Actually, every chapter is self-sufficient and could serve as an independent entry point to the whole book. The sequence chosen starts with three chapters introducing replication as a fundamental aspect of life. Here, the first chapter gives a general introduction to replication worth to be read by undergraduate students as well as academics, while the second chapter attempts to present a concept towards an anatomy of the eukaryotic replication fork. The third chapter adds the aspect of human diseases to the two more fundamental aspects in Part I. Replication is then linked by two interface-chapters in Part II to the world of DSB repair. The second chapter of Part II first reviews the history of the discovery of the physical nature of the gene and gene mutations. Exploiting gene targeting as an experimental, technical pillar, it attempts to compose the different models of DSB repair into a unifying synthesis. This joins Part II with four key aspects of DSB repair representing Part III. These four key aspects review the structure and function of the Rad50/SMC protein complexes in chromosome biology, further focus on the simplest pathway for DSB repair, i.e. non-homologous endjoining (NHEJ), and focus on a central gatekeeper crucial to avoiding cancer development, i.e. p53, and the most complex role of chromatin in DSB repair. The chapter on DNA base damage recognition in Part IV introduces DNA repair pathways involving one-strand lesions and their pleiotropic interactions with cell physiological functions, such as cell cycle, apoptosis and examples of major human diseases. While DSBs can be triggered and their repair can be studied at precisely defined positions on nucleotide level within a given chromosome, DNA damage introduced through radiation and other genotoxic stress factors follows a slightly different research lead. This is the common theme of the four chapters in Part IV. Ion irradiation as a tool to reveal tracts of damage throughout the eukaryote nucleus reminds us of cloud or Wilson chamber experiments in atomic physics detecting elementary particles of ionizing radiation. Here, in the final chapter of Part V, the tract of damage in a cloud of chromatin is monitored using antibodies to proteins characteristic of specific DNA repair pathways, as discussed in the last chapter of Part III. The four final chapters are important for many reasons, ranging from a significance for irradiation treated cancer patients, or victims of the Chernobyl disaster to the exposure to cosmic radiation of astronauts on long-term space missions. The original idea forthis book came from the 8thmeeting of the DNA Repair Network in Ulm, Germany, and would not have been possible without the support of the Deutsche Gesellschaft für DNA-Reparaturforschung (DGDR). Here I would like to mention especially Jürgen Thomale, Alexander Bürkle, Lisa Wiesmüller, Bernd Kaina and Friederike Eckardt-Schupp, who supported the initial idea and acted in the background.Further I would like to thank the anonymous referees for doing a great job in peer reviewing and improving the manuscripts. I also thank the University of Heidelberg, which gave access to their electronic journal collection. Last but not least, I have to thank Sabine Schreck (Springer, Heidelberg) without whom I could never have engaged in this project. Ursula Gramm(Springer,Heidelberg) and Michael Reinfarth (LETeXGbR, Leipzig) did a fine job copye diting all manuscripts and the Springer team succeeded well in establishing the SpringerLink OnlineFirst version of this bookseries, which provides authors withmore flexibility in the individual handling of their contributions.
Denna video visar uppackningen och demonstration av en MakerBot Replicator personliga FDM 3D-skrivare.
Vi är svenska återförsäljare av personliga 3D-skrivare. Kontakta info@creativetools.se eller 035-77 77 880 för mer information.
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This video shows the unboxing, setup and a short demonstration of the MakerBot Replicator personal 3D printer.
We are Swedish resellers of MakerBot. (info@creativetools.se / +46 35-77 77 880)
Small self-replicating bits of nucleic acid are a simple and essential intermediate in the origin of life, but calling them "viruses" is a stretch. The distinction is that so far as I know, every modern virus known to man is a) incapable of making protein and b) requires protein to function. This is no small distinction, because the entire elaborate structure of the ribosome and its associated factors and metabolic machinery are required for usual methods of protein synthesis. (There are some clever alternatives used for making antibiotics - see Nonribosomal peptide - but I'm not aware of any virus making a capsid, etc. using such tricks) I cannot swear to you that no primordial snippet of catalytic RNA could have survived from the beginning of the world until this day without ever having been part of a normal cycle of cell replication, but if it did, it has somewhere along the line developed a great need for ribosomes it doesn't have, and has borrowed enough sequences from ribosome-containing cells to make all the protein-coding genes we identify in it today.
Of course, you could postulate that self-replicating RNAs developed protein synthesis before the proper cell membrane, and then some never became part of cells. The problem is that it is hard to picture a complete protein biochemistry, at least one of the usual ribosome-oriented type with loose aminoacyl-tRNAs and the wizard's stew of biochemical precursors to amino acids, existing free or within a typical tight-packed viral capsid. One would think that the such a protein synthesis machinery open to the environment would have special adaptations to keep components from escaping, and probably would have use some more rudimentary genetic code than the completed cell. Yet none of these primitive features show up in viruses either.
The bottom line is that viruses by their nature could have picked up snippets of code anywhere, but they are not primordial organisms from the first days of life. Wnt (talk) 15:32, 8 August 2008 (UTC)
Replicate Designs produces Architectural Scale Models and Custom Displays along with props for advertising, movies and more.
Following up on the exploration of Alan Jaras, David Hull and John Swierzbin I used my modified brain wave camera to examine the area around BL86/DS51/R15. It seems John's worst fears regarding gamma ray energy are confirmed. These high energy sources are somehow combining to form light or energy entities. They seem able to replicate. Is this a new lifeform. If so it seems more like a virus using whole planets and stars as a host in order to multiply. The edge of the galaxy is now littered with lifeless dead planets
Single long macro exposure
Replicating a move by the Pennsylvania Reading Seashore Lines from years ago where trains from Camden would come to Tuckahoe, and then split up depending on which shore point they were headed to. In this case, the RDC was headed south on the Cape May Branch - November 2006
Here's a view of Aaron Delehanty’s desk in the Replications Lab. He is testing resin samples with different surface treatments and colors. Replicating objects with the degree of accuracy required for exhibitions involves a deep understanding of your materials. The work demands diligence, curiosity, continued practice, and ongoing experimentation with materials. Replications artists are a bit like chemists perfecting a formula.
(c) The Field Museum, photo by Emily Krakoff
I was really inspired by Anthropologie's January 2010 catalogue and wanted to replicate the feeling of the images. A week later, I got a school assignment to do just that. Enjoy :)
Funny story about this image. I showed this photo in one of my Fine Art class and the students and teacher asked what the fuzzy thing on the bed is. I told them it was her cat, and told them funny stories about her, including the kinda gross fact that she gets dingle berries sometimes. At the end of the critique, the professor tells me to show the front of the cat, not the dingle berries, next time.
The cat is facing the camera :(
A C41 test with the CineStill 400D, I have replicated, different days different lighting these scenes before and linked in the comments to the M8 in some cases and M2 for film with the Harman new C41 "experimental" fil for which there are two or three in some cases different scans. these are commercial scans as jpeg with straightening and tint tweaks only in Capture One.
Another film with a definitive "look" I will post more later that show the halation being a nuisance in some shots where it really wasn't wanted, sometimes it contributes positively. I should add box speed @400 with no "issues" like the Harman and my usual "sunny sixteen" approach.
Acrylic marker and ink on paper 9.85" x 13.85" May 8, 2025. www.saatchiart.com/en-jp/art/Drawing-Self-replicating-Sur...
Replicating the Geek to Freak chapter from the 4 Hour Body. It is the Science of Building Lean Muscle FAST!!!
See my progress on with the routine on geektoFREAK.net
Follow on twitter @geektoFREAK
Replication of original etched window bug for corner of glass on a rare Ferrari. It's a tiny, tiny, detail.
Veterans Memorial Park, Cape Coral, Florida. This memorial park was a very moving experience for me and I was compelled to take a moment for a silent prayer and to salute the flag as a former member of the US Navy.
This is my attempt to replicate a dish I enjoyed at a restaurant recently. This is one of those synergistic dishes where the components are quite simple, but their combination makes the dish wonderful. The components are: Parmesan polenta, roasted Brussels sprouts, broccoli pesto, and balsamic reduction. This is perfect comfort food for cold weather.
The polenta is made with polenta, water, salt, Parmesan cheese, and butter. The Brussels sprouts are roasted with olive oil, salt, and pepper. The broccoli pesto is made with broccoli, olive oil, garlic, lemon juice, Parmesan cheese, water, salt, pepper, and walnuts. For the balsamic reduction, I simply microwaved balsamic vinegar until it was thick, syrupy, and sweet.
DNA single-strand repair protein, Parp-1 (green dots), also helps with doublestrand breaks, according to Sugimura et al. At replicating regions of the genome (red and bue dots) Parp-1 slows the replication fork to allow double-strand repair enzymes to work. (JCB 183(7) TOC1)
This image is available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
Reference: Sugimura et al. (2008) J. Cell Biol. 183:1203-1212.
Published on: December 22, 2008.
Doi: 10.1083/jcb.
Read the full article at:
Denna video visar uppackningen och demonstration av en MakerBot Replicator personliga FDM 3D-skrivare.
Vi är svenska återförsäljare av personliga 3D-skrivare. Kontakta info@creativetools.se eller 035-77 77 880 för mer information.
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This video shows the unboxing, setup and a short demonstration of the MakerBot Replicator personal 3D printer.
We are Swedish resellers of MakerBot. (info@creativetools.se / +46 35-77 77 880)