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Since my parents have also gone through the 23andMe DNA analysis, we can compare genes.
Thanks for the endurance mom! For those who know her, this is a strong point. =)
The genome-wide comparison above covers almost a million SNPs (Single Nucleotide Polymorphisms), which are point letter mutations (like A → G or T → C swaps) that have accumulated in relatively recent generations and vary across the peoples of the planet.
For each of the traits, I added a note with explanatory text from 23andMe. For example, the 135 SNPs related to endurance cover “genes that have been associated with different endurance phenotypes, including VO2max (your maximum capacity to transport and utilize oxygen), running distance, exercise time, and power output.”
Immune System Compatibility is also pretty interesting as it is almost entirely genetic, and relates to organ transplant potential and mate preference (we have a natural aversion to people with immune systems too similar to our own). Whew!
The analysis above is on the 22 autosomal chromosomes which are a blend from mom and dad. To look at a segment of DNA that we know only came from Mom, we look at the mitochondrial DNA (mtDNA) which is outside the nucleus and resident in each of the mitochondria, or “power plants” of our cells. When you were a single cell, that cell came from mom. Dad’s genetic contribution went straight to the nucleus. And as that cell proceeded to divide, the mtDNA was copied as well, now replicated in all of the cells of your body, and entirely derived from mom. The sperm’s mitochondria are mainly in the tail, and the egg cell destroys any that might make it across. And it is abundant. Your liver cells, for example, have about 1500 mitochondria and about 10 thousand copies of mom’s mtDNA per cell.
By the way, this snippet of code is a clue to the endosymbiosis of the distant past where our cells engulfed energetic bacteria to power our much larger cells. The mtDNA forms a circle, instead of a strand, as found in viruses, bacteria and archaea. It also has a high mutation rate, like bacteria, which makes it useful for genetic archaeology.
So, for Mother's Day, it seemed appropriate to look at my mom and all of the moms in her maternal line. Our mtDNA pegs us as Maternal Haplogroup H11a, which is common to Nicolaus Copernicus and Marie Antoinette. =)
23andMe summarizes: "H originated in the Near East and then expanded after the peak of the Ice Age into Europe, where it is the most prevalent haplogroup today. It is present in about half of the Scandinavian population...
H originated about 40,000 years ago in the Near East, where favorable climate conditions allowed it to flourish. About 10,000 years later it spread westward all the way to the Atlantic coast and east into central Asia as far as the Altay Mountains.
About 21,000 years ago an intensification of Ice Age conditions blanketed much of Eurasia with mile-thick glaciers and squeezed people into a handful of ice-free refuges in Iberia, Italy, the Balkans and the Caucasus. Several branches of haplogroup H arose during that time, and after the glaciers began receding about 15,000 years ago most of them played a prominent role in the repopulation of the continent.
Haplogroup H achieved an even wider distribution later on with the spread of agriculture and the rise of organized military campaigns.
Recent research indicates Haplogroup H made its way into the deserts of northern Africa via the Strait of Gibraltar."
And for those wondering how we know Copernicus’ mtDNA, we turn to The Spittoon: "Even though DNA begins degrading immediately following death, the genetic material is often preserved in the teeth for hundreds or thousands of years. Scientists studying ancient DNA (aDNA) usually focus on the type of DNA that has the greatest chance of surviving: mitochondrial DNA (mtDNA), which is passed exclusively from mother to children. The sheer abundance of mtDNA makes it much more likely to survive; each cell contains hundreds of copies."
Free Christmas Quilt designed for a past edition of Australian Homespun. Will be available shortly on my blog for free.
is there anything special about you.
Grandiose delusions or delusions of grandeur are principally a subtype of delusional disorder but could possibly feature as a symptom of schizophrenia and manic episodes of bipolar disorder. Grandiose delusions are characterized by fantastical beliefs that one is famous, omnipotent, or otherwise very powerful. The delusions are generally fantastic, often with a supernatural, science-fictional, or religious bent (for example, belief that one is an incarnation of Jesus Christ).
Grandiose delusions are distinct from grandiosity, in that the sufferer does not have insight into his loss of touch with reality.
The heaviest pen I own, the Apogee in medium point. After a week with this, I regretted getting it in medium, but all it really means is that I don't use it in my Moleskine. It's still quie good for work. It is a fantastic pen, but so very heavy, especially with the cap posted.
The ink is mostly Montblanc black, with a splash of Waterman black in it. Montblanc ink I've finally decided is too thin for my tastes, but I don't have the heart to get rid of it, so I'm trying to use it up quickly. Ditto for the Quink, which I simply don't like.
Oh yes, and CAMERAS ARE KILLING ME!
the future has become the past....leather bound copies of La Technique Moderne slowly age, fade and decay....
Texting While Waiting for the Tram
Los Angeles, California
A woman texting while waiting for someone to arrive on the tram on a cold Fall night.
camera: Nikon D750 DSLR
lens: AF-S Nikkor 50mm 1:1.4 G "50mm f/1.4 G"
filter: Hoya HD Protector (Clear)
support: hand held
software: ACDSee Pro 8 Ultimate (64 bit)
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©2015 Chris Grossman, all rights reserved
this work is intended...meanings are ... simple. these will give interest...and...understanding. a simple scheme of...marking...words. many words...have...been introduced...and...included in the body of the work.
On the Eve of New Year holidays, the company Louis Vuitton ( www.louisvuitton.com/ ) has made a gift to their customers. Right in the store customers could sign a greeting cards.
Each customer himself thought the text of wishes, and I wrote this text on cards. A calligraphical composition – pure improvisation. Postcards with warm wishes was a touching sincere complements to the magnificent gifts, bought at the store.
В канун Новогодних праздников компания Луи Виттон ( www.louisvuitton.com/ ) сделала подарок своим покупателям, предоставив эксклюзивную услугу, – возможность подписать поздравительную открытку. Каждый покупатель сам сочинял текст пожелания, а я писала этот текст на открытке. Каллиграфическая композиция была чистой импровизацией и делалась в присутствии клиента. Фирменная открытка с тёплыми и искренними словами – прекрасный и трогательный сюрприз, дополняющий великолепие подарка, купленного в Луи Виттон.
This badge is to recognize the quilters for 3 years.
Special thanks to: Mandy (Mimi) for all of her templates, guidance, and the digital quilted creation of the 2015 BCA quilt using square contributions from friends.
Mandy started the Quilt to commemorate the fact her own mom was a survivor. And, Mandy has been privileged to spearhead this project for all 8 years.
Chris (martian cat) has participated in all 8 years of the digital BCA quilt. And, she has been Assistant Project Manager for 5 years of the Quilt. Mandy "met" her during the making of the first one. Chris tirelessly not only works on several sample squares each year, but secures many of our participants as well.
I just added a vintage NASA sticker to my deck, and it sports the old “spaghetti logo” of 1978.
The small text at the bottom reads:
“NASA FORM 1368A AUG 1978 PREVIOUS EDITION IS OBSOLETE.”
The history of the NASA logo is a bit unusual:
1915 NACA is formed, using winged logo (see below)
1958 NACA is dissolved and NASA is formed, blue circular seal is designed
1959 NASA simplifies the seal for its new logo
1975 NASA has a new logo designed because the old logo is difficult to reproduce with current technology. A mudslinging campaign against the old logo is started to promote the new logo. The term "Meatball logo" is coined as it looks like a blue meatball. The new sleek letters look like spaghetti. So this 1978 sticker is of that era.
1992 NASA, Administrator Daniel Golden longs for the good old days and revives the old logo. He starts a campaign to eradicate the spaghetti from existence, deriding the logotype as "the worm". He launched a "look for the worm" hunt that summer with the most prominent one being on the side of NASA headquarters (where Dan Goldin had his office). When Dan visited an office, people would scurry to tape over any remaining worms that may lie about.
To this day, any use of the worm insignia is highly scrutinized by the Visual Identity Coordinator at NASA Headquarters.