View allAll Photos Tagged Development
Drug development is a risky business. More than half of candidate drugs that look promising in the research lab will ultimately fail. More than a quarter of drugs that reach the clinical trial stage will be rejected as ineffective. However, the wealth of genomic information now available through public databases - in particular, the rapidly growing number of known associations between diseases and specific genes - may significantly improve the drug-development success rate. At least, success rates will improve if drug developers let genomics guide their choice of molecular targets for research, according to a team of pharmaceutical industry and academic scientists.
Credit: Ernesto del Aguila III, NHGRI.
(spy)camera > Porst KX50 (Yashica Atoron rebranded) (*)
film > Minox Minocolor400 (@200iso)
development > Tetenal Colortec C41, 38 °C, homemade in tank AP Compact, attached on an old film 120 already developed.
scanned > Epson V600
negli ultimi frame, la pellicola è uscita dalla spirale e ha restituito questi colori strani... ;/)
Paper: Southworth Parchment Deed (old stock)
Iodiser: Le Gray / Pelegry (no whey, just lactose)
Sensitiser: Le Gray. 7% Silver, 7% Acetic
Washed for five minutes, dried, then exposed.
Exposure: 10.5 minutes @ f/3.7, EV 9 (dark, overcast, indoors)
Development: immersed for ~ 40 seconds in Ferrous Sulphate developer.
Ferrous Sulphate__ 6.8g
Glacial acetic acid__ 12ml
Distilled water ____ 200ml
washed for ten minutes, then fixed in a 9% solution of anhydrous hypo.
Observations: Iron development was rapid, but produced a weak image. The negative was floated image side down, then flipped and rocked to immerse. All details were out by 30 seconds, then nothing seemed to change, so I removed the paper for fear of fogging. Of the the three papers tested, this was the strongest. Mars Vellum and Canson Marker developed in under a minute, but the details were barely discernible. I made an attempt at intensification by adding aceto-nitrate to the developer, but this was a mistake. Within about a minute, the silver had precipitated out of the developer, resulting in a fogged negative (canson).
For my next test, I will reduce the wash time to two minutes after sensitising. I will also test an unwashed sheet.
a bit lopsided - that's what happens when you prepare you pictures on bouncy train....Around March 2014. Argyll Street. London.
C-41, E-6, 510-pyro, HC-110, wetting agent, a 2-roll and 3-roll Paterson tank, alkaline rapid fixer, measuring cups, thermometer and some extra spare powders. Not much space, all must fit in this plastic box.
USAID hosted a Signature Event —Shared Progress: Modernizing Development Finance on September 22, 2016 in New York City, NY. Running concurrently to the United Nations General Asembly, the event highlighted the challenges and opportunities for financing current and future development goals.
During the event, UAID Administrator Gayle Smith and Managing Director of the International Monetary Fund (IMF), Christine Lagarde, discussed how to foster an enabling environment for private investment and increasing domestic resource mobilization. A panel of speakers also offered recommendations on how to make better use of the three streams of finance in order to improve development outcomes.
Photo by Ellie Van Houtte/USAID
I've been taking macros of our "bleeding heart" plants, as the flowers develop. Here are a few of my shots.
The background this picture was taken against wasn't great, so have some edited-in bricks instead.
Change is afoot on the Toton Lane to Nottingham park and ride service, since the temporary allocation of mostly double deckers (for social distancing) can be eased off slightly and various members of the RB fleet fill in while the branded vehicles receive attention, with a couple being off the road at any given time. The first of these was 28, now back in traffic on the P&R in its updated livery so now the other buses can have their turn at being repainted.
Reduced PVR:
Although there are six buses branded for the park and ride, a revised timetable sees the same level of service (every 10 min departures with a small amount of recovery time at Toton Lane) but with a PVR of five buses, completely cutting out one of the service boards because a few months ago I sat up all night devising an ingenious new timetable. There are five boards Monday to Saturday and three on a Sunday, so having six branded buses is a massive overkill; four, maybe five would be better.
New Livery for the Darts:
Because I tried to paint all six P&R buses in 2017/18 at the same time, it ended up taking ages and the paint finish was pretty rubbish across all of them. Also I'm a bit sick of the livery now, only having lime green at the front and looking generally uninspired. Because I ideally want to get some more double deckers for the P&R and oust at least three of the Darts onto the 201/211 I wanted to change the livery so it looked better for the P&R but could also be repurposed without me having to repaint them all again.
Repainting 28:
28 is the first Dart to be painted into the revised livery, which isn't too much of a drastic change from the previous one but different enough. The most important part is that I got the finish far better than before, so the whole thing looks neater. Unfortunately I managed to sand off most of the front detail so it looks rather flat... hopefully I won't end up doing the same to the other three. I eventually decided the headlights I painted on looked too rectangular, so I've changed them slightly since this photo and now 28 looks far more like an SLF Pointer. (with the 'rectangle' lights it looks almost like a Mercedes O405!)
Repainting 27 and 31:
Next to be pulled from service is 27, which I'm currently in the process of repainting. 31 wasn't meant to be done until after the Darts, but I had a closer look at it and thought it looked so bad I needed to fix it immediately, so that's being painted at the moment too. I just didn't like the idea of the revised P&R livery on the double deckers, so it's staying in the original P&R livery for now. What I do with it in the future I can worry about when I get to that stage.
Potential for New Buses:
As good as they are, the Darts are a bit of a compromise on the P&R since they are rather small for the job they have. The P&R could really do with a 100% allocation of deckers, but the existing double deckers in the fleet are a bit of a motley collection and, besides, none of them are Euro 6; unlike the Darts with their retrofitted E200 engines. I thought it wouldn't be too impossible to find four - five at a push - double deckers this year to completely renew the P&R fleet, enabling the six buses you see here to be cascaded off to other interesting developments on the RB network.
Of course this relies on some bus/model shows taking place and then me actually getting to them... and then them having models of low floor deckers for sale that aren't £25+ apiece. Hold on, this is sounding less likely by the minute.
In The Meantime:
For now the P&R is mostly back to normal, with 25/6/8/9 on it (providing they aren't breaking down that day) and the 5th board being covered by just about anything Enviro-Dart sized or bigger... 8 the ALX500, 14 the B7 Artic and 20 the BYD electric have all filled in although more commonly it's either 12, 16 or 30. Since going back to normal, the P&R hasn't seen either of the Excels again... yet. When 27 and 31 are finished I'll move on to the other two Darts, then 29 providing I don't change my mind again like I did with 31. Hopefully by then I'll have figured out how viable my "buy 4 or 5 double deckers" plan is and maybe even got some of them! Who knows?
(I mean I really do have a load of things planned for RB which pretty much hinge on me replacing all the current P&R fleet with new deckers.)
© Tan Bing Dun 2013
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Management is one basic piece of the business. With better and viable management, a business can get wanted development and benefit in less time. On account of digitization, Management Software is being utilized in each sort of business. Same goes for restaurant or bar business. To get a specific development, restaurant and bar business people counsel Restaurant and Bar Management Software Development Services to build up a management software for them.
Source: maxanderson.postach.io/post/what-benefits-can-be-get-by-r...
The Punjab Energy Development Agency (PEDA) recently allocated 500 MW worth of solar PV power plants to five separate developers. All the projects were allocated at less than Rs 6.00/kWh (9.2¢/kWh), the lowest tariffs for any project allocated under the Punjab solar power policy so far.
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Kristina is an 18 years old ballet dancer in Bosnia and Herzegovina. After the ballet hall of the Sarajevo Music School closed due to COVID-19, she had to practice in the confines of her little room for 5 months.
Now Kristina has received some good news. The school building, which is protected as a national monument of Bosnia and Herzegovina has been given a face-lift, as part of UNDP’s effort in partnership with the Embassy of Sweden to contribute to environmental protection and economic development of the country. When she returned, she was pleasantly surprised:. The building where she has been going for the past seven years is no longer drab and dilapidated. She now gets to do all the spins her heart desires!
Read more: bit.ly/2F46FYo
Photos: I.Kapetanovvić, S.Omerbašić, D.Ruvić/ UNDP Bosnia and Herzegovina
Copper was discovered at Kuridala in 1884 and the Hampden Mine commenced during the 1890s. A Melbourne syndicate took over operations in 1897 and with increasing development of the mine in 1905 - 1906 the Hampden Cloncurry Limited company was formed. The township was surveyed as Hampden in 1910 (later called Friezland, and finally Kuridala in 1916). The Hampden Smelter operated from 1911 to 1920 with World War I being a particularly prosperous time for the company. After the war, the operations and the township declined and the Hampden Cloncurry Limited company ceased to exist in 1928. Tribute mining and further exploration and testing of the ore body has continued from 1932 through to the present day.
The Kuridala Township and Hampden Smelter are located approximately 65km south of Cloncurry and 345m above sea level, on an open plain against a background of rugged but picturesque hills.
The Cloncurry copper fields were discovered by Ernest Henry in 1867 but lack of capital and transport combined with low base metal prices precluded any major development. However, rising prices, new discoveries in the region and the promise of a railway combined with an inflow of British capital stimulated development. Additionally, Melbourne based promoters eager to develop another base metal bonanza like Broken Hill led to a resurgence of interest, especially in the Hampden mines.
The copper deposits at Kuridala (initially named Hampden) were discovered by William McPhail and Robert Johnson on their pastoral lease, Eureka, in January 1884. The Hampden mine was held by Fred Gibson in the 1890s and acquired in 1897 by a Melbourne syndicate comprising the 'Broken Hillionaires' - William Orr, William Knox, and Herman Schlapp. They floated the Hampden Copper Mines N. L. with a capital of £100,000 in £100 shares of which 200 were fully paid up. With this capital, they commenced a prospecting and stockpiling program sending specimens to Dapto and Wallaroo for testing. Government Geologist, W.E. Cameron's report on the district in 1900 discouraged investors as he reported that few of the lodes, other than the Hampden Company's main lode at Kuridala, were worth working.
A world price rise in copper in 1905, combined with a government decision in 1906 to extend the Townsville railway from Richmond to Cloncurry, stimulated further development. The Hampden Cloncurry Copper Mines Limited was registered in Victoria in March 1906 to acquire the old company's mines. However, the company only had a working capital of £35,000 after distributing vendor's shares and buying the Duchess mines. During this period there were over 20 companies investing similarly on the Cloncurry field.
The township was surveyed by the Mines Department around 1910 and was first known as Hampden after the mines discovered in the 1880s. By 1912 it was called Friezland, however was officially renamed Kuridala in October 1916 to minimise confusion with another settlement in Queensland. The reason for this change was considered to be linked to German names being unpopular at the outbreak of World War I.
Hampden Cloncurry Copper Mines Limited and its competitor, Mount Elliott, formed a special company in 1908 to finance and construct the railway extension from Cloncurry through Malbon, to Kuridala, and Mount Elliott. The company reconstructed in July 1909 by increasing its capitalisation, and concluding arrangements for a debenture issue to be secured against its proposed smelters. Its smelters were not fired until March 1911 and over the next three years 85,266 tons of ore were treated with an initial dividend of £140,000 being declared in 1913. In one month in 1915 the Hampden Smelter produced 813 tons of copper, an Australian record at that time.
Concern over the dwindling reserves of high grade ore led to William Corbould, the general manager of Mount Elliott mines, negotiating an amalgamation with Hampden Cloncurry to halt the fierce rivalry. But the latter was uninterested having consolidated its prospects in 1911 by acquiring many promising mines in the region, and enlarging its smelters and erecting new converters. In 1913, following a fire in the Hampden Consol's mine, Corbould convinced his London directors to reopen negotiations for a joint venture in the northern section of the field which still awaited a railway. Although Corbould and Huntley, the Hampden Cloncurry general manager, inspected many properties, the proposal lapsed.
The railway reached the township by 1910. A sanitary system was installed in 1911, after a four month typhoid epidemic, and a hospital erected by 1913, run by Dr. Old. It was described as the best and most modern hospital in the northwest. At its height, the town supported six hotels, five stores, four billiard saloons, three dance halls, and a cinema, two ice works, and one aerated waters factory, and Chinese gardens along the creek. There were also drapers, fruiterer, butcher, baker, timber merchant, garage, four churches, police station, court house, post office, banks, and a school with up to 280 pupils. A cyclone in December 1918 damaged the town and wrecked part of the powerhouse and smelter.
A comprehensive description of the plant and operations of the Kuridala Hampden mines and smelters was given by the Cloncurry mining warden in the Queensland Government Mining Journal of the 14th of September 1912. Ore from other company-owned mines (Duchess, Happy Salmon, MacGregor, and Trekelano) was railed in via a 1.2km branch line to the reduction plant bins, while the heavy pyrites ore from the Hampden mines was separated at the main shaft into coarse and fine products and conveyed to separate 1,500 ton capacity bins over a standard gauge railway to the plant.
A central power plant was installed with three separate Dowson pressure gas plants powered by three tandem type Kynoch gas engines of 320hp and two duplex type Hornsby gas engines of 200hp. Two Swedish General Electric Company generators of 1,250kw and 56kw running at 460 volts, supplied electricity to the machines in the works, fitting shops and mine pumps. Electric light for the mine and works was supplied by a British Thompson-Houston generator of 42kw, running at 420 volts. The fuel used in the gas producers was bituminous coal, coke or charcoal, made locally in the retorts.
The reduction plant consisted of two water-jacket furnaces, 2.1m by 1m and 4.2m by 1m, with dust chambers and a 52m high steel stack. There were two electrically driven converter vessels, each 3.2m by 2.3m. The molten product ran into a 3.7m diameter forehearth, while the slag was drawn off into double ton slag pots, run to the dump over 3 foot gauge, 42lb steel rail tracks. The copper was delivered from the forehearth to the converters. A 1.06m gauge track ran under the converters and carried the copper mould cars to the cleaning and shipping shed, at the end of which was the siding for railing out the cakes of blister copper.
The war conferred four years of prosperity on the Cloncurry district despite marketing, transport, and labour difficulties. The Hampden Cloncurry Company declared liberal dividends during 1915 - 1918: £40,000, £140,000, £52,500 and £35,000 making a total disbursement since commencing operations of £437,500. Its smelters treated over a quarter of a million tons of ore in this period, averaging over 70,000 tons annually. The company built light railways to its mines (e.g. Wee MacGregor and Trekelano) to ensure regular ore supplies and to reduce transport costs. In order to improve its ore treatment, Hampden Cloncurry installed a concentration plant in 1917. In 1918 an Edwards furnace was erected to pre-roast fine sulphide concentrates from the mill before smelting.
The dropping of the copper price control by the British government in 1918 forced the company into difficulties. Smelting was postponed until September 1919 and the company lost heavily during the next season and had to rely on ores from the Trekelano mine. Its smelter treated 69,598 tons of ore in 1920, but the company was forced to halt all operations after the Commonwealth Bank withdrew funds on copper awaiting export.
Companies and mines turned to the Theodore Labor Government for assistance but they were unsympathetic to the companies, even though they alone had the capacity to revive the Cloncurry field. More negotiations for amalgamation occurred in 1925 but failed, and in 1926 Hampden Cloncurry offered its assets for sale by tender and Mount Elliott acquired them all except for the Trekelano mine. The company was de-listed in 1928.
The rise and decline of the township reflected the company's fortunes. In 1913 there were 1,500 people increasing to 2,000 by 1920, but by 1924 this had declined to 800. With the rise of Mount Isa, Kaiser's bakehouse, the hospital, courthouse, one ice works, and a picture theatre, moved there in 1923 followed by Boyds' Hampden Hotel (renamed the Argent) in 1924. Other buildings including the police residence and Clerk of Petty Sessions house were moved to Cloncurry.
In its nine years of smelting Hampden Cloncurry had been one of Australia's largest mining companies producing 50,800 tons of copper (compared with Mount Elliott's 27,000), 21,000 ounces of gold and 381,000 ounces of silver. A more permanent achievement was its part in creating the metal fabricating company, Metal Manufacturers Limited, of which it was one of the four founders in 1916. Much of the money which built their Port Kembla works into one of the country's largest manufacturers came from the now derelict smelters in north-west Queensland.
In 1942 Mount Isa Mines bought the Kuridala Smelters for £800 and used parts to construct a copper furnace which commenced operating in April 1943 in response to wartime demands. The Tunny family continued to live at Kuridala as tributers on the Hampden and Consol mines from 1932 until 1969 and worked the mines down to 15.25m. A post office operated until 1975 and the last inhabitant, Lizzy Belch, moved into Cloncurry about 1982.
Further exploration and testing of the Kuridala ore body has occurred from 1948 up until the present with activities being undertaking by Mount Isa Mines, Broken Hill South, Enterprise Exploration, Marshall and James Boyd, Australian Selection, Kennecott Exploration, Carpentaria Exploration, Metana Minerals, A.M. Metcalfe, Dampier Mining Co Ltd, Newmont Pty Ltd, Australian Anglo American, Era South Pacific Pty Ltd, CRA Exploration Pty Ltd, BHP Minerals Ltd, Metana Minerals and Matrix Metals Ltd.
Source: Queensland Heritage Register.
The first order of business after #00 was crushed was to establish a new development car. Of the eleven production units, we had saved #09 specifically for a "special case".
Whether it was for a certain buyer or in this case, the need for a dev car, #09 was there just in case.
Here is how the car sits today. Simple, yet effective. Surely it won't stay like this forever, but in it's current form I can't help but admire it's simplicity.
Photo: Ryan Gates
I had a successful molding run yesterday, and as a result there are now two different versions of the BrightScreen: the original microprism style on the left and a new one with a diagonal split image spot inside a microprism collar, shown on the right. This was I think the fourth molding run since the spring of 2018, and we seem to learn something on each run. We're actually getting pretty good at this now......
Makes for a long day, though, as the molding shop is a bit of a drive from home. I left the house at 7:30 yesterday morning and got back home at 9:30 last night. But I have enough screens on hand now that I won't have to do it again for a while.
So I have been working on this for a week. I have now figure out how to add the rig, make the animation, add the mesh modifier upload the mesh, and script it to work. There is a crazy limitation on distance, and I developed a hack to get more distance on the animations. I'm sure I know someone thinking, "how is he getting the distance so far"