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The 4th annual Missed Connections event took place on Valentine’s Day (Thursday) 2014 at the New York Transit Museum. Guests got to spin Craigslist postings about those “lost subway love matches” into poetry and music. There was also art, local Brooklyn tastings, valentine-making, and a photo booth. Photo: Metropolitan Transportation Authority / Patrick Cashin
Students of color, the LGBTQ community and female students convened in Reeve Union Ballroom April 2 to hone their networking skills with professionals at Creating Connections: Empowering through Networking, a Social Justice Week event hosted by University of Wisconsin Oshkosh Career Services.
Connections 2020 brought together 900+ parents, alumni, faculty, staff, and friends to celebrate Lab's strengths and the power of philanthropy. The event raised over $1.6M for financial aid and professional development.
(Photo by Anna Johnson)
Goal::
To make giving information less of a 1-sided transaction and more of a way for a church to pastor an individual
Audience:
First Time Guests to Regular Attenders
Direction
The idea behind this new updated connection card was to create something that felt very "mobile first" friendly but translated to paper.
Secondarily, I wanted to take the connection card experience which seems like a very one-sided transaction of giving an organization your information, somewhere that was a little more meaningful.
This Connection Card design is based primarily around the person's Decision so that we can pastor them better.
Later on, I will take this same design and create an online form that will sit in our website and app.
Your feedback, favorites, and comments are much appreciated!
Update:
This iteration was improved upon from this original concept. I added a map to know where to bring the card, reduced the amount of input fields to make it less daunting, and added a box for kids' names. I also move the perforation to the middle since we had room and lowered the cost of printing. Most of the Decision icons came from Life.Church - so thanks to them!
Check out my other work (websites/apps/logos): andstud.io
From Wikipedia, the free encyclopedia
Coordinates21°19′07″N 157°55′21″W
TypeUS Air Force Base
Site information
OwnerDepartment of Defense
OperatorUS Air Force
Websitewww.hickam.af.mil
Site history
Built1938 (as Hickam Field)
In use1938 – 2010
FateMerged in 2010 to become an element of Joint Base Pearl Harbor–Hickam
Airfield information
IdentifiersIATA: HIK, ICAO: PHIK, FAA LID: HIK
Elevation3.9 metres (13 ft) AMSL
Runways
Direction Length and surface
8L/26R 3,752.6 metres (12,312 ft) Asphalt
8R/26L 3,657.6 metres (12,000 ft) Asphalt
4R/22L 2,743.2 metres (9,000 ft) Asphalt
4L/22R 2,118.9 metres (6,952 ft) Asphalt
8W/26W 1,524 metres (5,000 ft) Water
4W/22W 914.4 metres (3,000 ft) Water
Airfield shared with Honolulu International Airport
Source: Federal Aviation Administration[1]
U.S. National Register of Historic Places
Official nameHickam Field
U.S. National Historic Landmark District
Designated16 September 1985
Reference no.85002725
Periods of significance1925–1949
Areas of significanceMilitary
Hickam Air Force Base is a United States Air Force installation, named in honor of aviation pioneer Lieutenant Colonel Horace Meek Hickam. The installation merged in 2010 with Naval Station Pearl Harbor to become part of the newly formed Joint Base Pearl Harbor–Hickam, on the island of Oʻahu in the State of Hawaiʻi. The base neighbors Daniel K. Inouye International Airport and currently shares runways with the airport for its activities and operations.
Major units
Hickam is home to the 15th Wing (15 WG) and 67 partner units including Headquarters of Pacific Air Forces (PACAF), Hawaii Air National Guard and the 154th Wing (154 WG) of the Hawaii Air National Guard. The Air Mobility Command's 515th Air Mobility Operations Wing (515 AMOW) provides tactical and strategic airlift within the Pacific region.
In addition, Hickam supports 140 tenant and associate units.
The 15th Wing is composed of four groups each with specific functions. The 15th Operations Group (15 OG) controls all flying and airfield operations. The 15th Maintenance Group (15 MXG) performs aircraft and aircraft ground equipment maintenance. The 15th Mission Support Group (15 MSG) has a wide range of responsibilities but a few of its functions are Security, Civil Engineering, Communications, Personnel Management, Logistics, Services and Contracting support. The 15th Medical Group (15 MDG) provides medical and dental care.
15th Operations Group (Tail Code: HH)
15th Operations Support Squadron
25th Air Support Operations Squadron
535th Airlift Squadron (C-17)
65th Airlift Squadron (C-37)
19th Fighter Squadron (F-22)
15th Maintenance Group
15th Medical Group
15th Wing Staff Agencies
The 535th Airlift, 96th Air Refueling, and 19th Fighter Squadrons are each hybrid units joined with the Hawaii Air National Guard's 204th Airlift, and 199th Fighter Squadrons, respectively. These units are structured according to the Total Force Integration (TFI) concept, and as such have both an active duty Commander and a Guard Commander. They share missions as well as equipment.
Major Tenant Units
154th Wing Hawaii Air National Guard
515th Air Mobility Operations Wing
History
Origins
In 1934, the Army Air Corps saw the need for another airfield in Hawaii when Luke Field on Ford Island became too congested for both air operations and operation of the Hawaiian Air Depot. 2,225 acres (9.00 km2) of land and fishponds adjacent to John Rodgers Airport and Fort Kamehameha were purchased by the War Department from the Bishop, Damon and Queen Emma estates for a new air depot and air base at a cost of $1,095,543.78.[2] It was the largest peacetime military construction project in the United States to that date and continued through 1941.
The Quartermaster Corps was assigned the job of constructing a modern airdrome from tangled algaroba brush and sugar cane fields adjacent to Pearl Harbor. Planning, design, and supervision of construction were all conducted by Capt. Howard B. Nurse of the QMC. The site consisted of ancient, emerged coral reef covered by a thin layer of soil, with the Pearl Harbor entrance channel and naval reservation marking its western and northern boundaries, John Rodgers Airport (HIA today) to the east, and Fort Kamehameha on the south.[3] The new airfield was dedicated on 31 May 1935 and named in honor of Lt Col Horace Meek Hickam, a distinguished aviation pioneer who was killed in an aircraft accident the previous November 5 when his Curtiss A-12 Shrike, 33-250, hit an obstruction during night landing practice on the unlighted field at Fort Crockett in Galveston, Texas and overturned. Construction was still in progress when the first contingent of 12 men and four aircraft under the command of 1st Lt Robert Warren arrived from Luke Field on September 1, 1937.[2]
Hickam Field was completed and officially activated on September 15, 1938. By November 1939 all Air Corps troops and activities—including most facilities such as the chapel, enlisted housing, and theater, which were dismantled and ferried in sections across the channel—had transferred from Luke Field with the exception of the Hawaiian Air Depot, which required another year to move.[2] In early 1939 construction began on the main barracks, a single three-story nine-winged structure to house 3,200 men at a cost of $1,039,000. Personnel began moving into the barracks in January 1940, and by its completion on 30 September 1940, it was fully occupied and the largest structure of any kind on an American military installation. It included barber shops, a 24-hour medical dispensary, a laundry, a post exchange, multiple squadron dayrooms, and a massive consolidated mess hall at its center, and thus was dubbed the "Hickam Hotel".[4]
Hickam was the principal army airfield in Hawaii and the only one large enough to accommodate the B-17 Flying Fortress bomber. In connection with defense plans for the Pacific, aircraft were brought to Hawaii throughout 1941 to prepare for potential hostilities. The first mass flight of bombers (21 B-17Ds) from Hamilton Field, California arrived at Hickam on 14 May 1941. By December, the Hawaiian Air Force had been an integrated command for slightly more than one year and consisted of 754 officers and 6,706 enlisted men, with 233 aircraft assigned at its three primary bases: Hickam, Wheeler Field (now Wheeler Army Airfield), and Bellows Field (now Bellows Air Force Station).
World War II
When the Imperial Japanese Navy attacked Oahu on 7 December 1941, its planes bombed and strafed Hickam to eliminate air opposition[5] and prevent American aircraft from following them back to their aircraft carriers. Hickam suffered extensive damage and aircraft losses, with 189 people killed and 303 wounded. Notable casualties included nine Honolulu Fire Department (HFD) firefighters (three killed, six injured) who fought fires at Hickam during the attack; they later received Purple Hearts for their heroic actions that day in peacetime history, the only civilian firefighters awarded as such to date.
During World War II, the base became a major center for training pilots and assembling aircraft. It also served as the hub of the Pacific aerial network, supporting transient aircraft ferrying troops and supplies to—and evacuating wounded from—the forward areas—a role it would reprise during the Korean and Vietnam wars and earning it the official nickname "America's Bridge Across the Pacific".
Cold War
After World War II, the Air Force in Hawaii consisted primarily of the Air Transport Command and its successor, the Military Air Transport Service (MATS), until 1 July 1957 when Headquarters Far East Air Forces completed its move from Japan to Hawai‘i and was redesignated the Pacific Air Forces (PACAF). The 15th Air Base Wing, host unit at Hickam AFB, supported the Apollo astronauts in the 1960s and 1970s; Operation Homecoming (return of prisoners of war from Vietnam) in 1973; Operation Babylift / New Life (movement of nearly 94,000 orphans, refugees, and evacuees from Southeast Asia) in 1975; and NASA's Space Shuttle flights in the 1980s and 1990s. Hickam is home to the 65th Airlift Squadron which transports theater senior military leaders throughout the world in the C-37B and C-40 Clipper aircraft. In mid-2003, the 15th Air Base Wing (15 ABW) was converted to the 15th Airlift Wing (15 AW) as it prepared to beddown and fly the Air Force's newest transport aircraft, the C-17 Globemaster III. The first Hickam-based C-17 arrived in February 2006, with seven more to follow during the year. The C-17s will be flown by the 535th Airlift Squadron.
Hawaii ANG 199th Fighter Interceptor Squadron F-102s in maintenance hangar at Hickam, 1976 Convair F-102A-30-CO Delta Dagger 54-1373 identifiable, aircraft now on static display at Hickam.
On September 16, 1985, the Secretary of the Interior designated Hickam AFB a National Historic Landmark, recognizing its key role in the World War II Pacific campaign.[6] A bronze plaque reflecting Hickam's "national significance in commemorating the history of the United States of America" took its place among other memorials surrounding the base flagpole. Dominating the area is a large bronze tablet engraved with the names of those who died as a result of the 1941 attack. Other reminders of the attack can still be seen. Bullet holes mark many buildings in use, including World War II era hangars and the base hospital.,[7] including the tattered American flag that flew over the base that morning. It is on display in the lobby of the Pacific Air Forces Headquarters building, whose bullet-scarred walls (the structure was a barracks and mess hall known as "the Big Barracks" in 1941) have been carefully preserved as a reminder to never again be caught unprepared.
Accidents and incidents
On 22 March 1955, a United States Navy Douglas R6D-1 Liftmaster on descent to a landing in darkness and heavy rain strayed off course and crashed into Pali Kea Peak in the southern part of Oahu's Waianae Range, killing all 66 people on board. It remains the worst air disaster in Hawaii's history and the deadliest heavier-than-air accident in the history of U.S. naval aviation.[8][9][10][11]
Previous names
Flying Field, Tracts A and B, near Ft Kamehameha, United States Army (Origins)
Hickam Field, 21 May 1935
Army Air Base, APO #953 (official designation, 16 May 1942 – 31 May 1946)
Hickam Field, 1 Jun 1946
Hickam Air Force Base, 26 March 1948 – 1 October 2010
Major commands to which assigned
1935–1940: Hawaiian Dept, United States Army
1940–1942: Hawaiian Air Force
1942–1944: Seventh Air Force
1944–1945: Army Air Forces Pacific Ocean Areas (Provisional)
1945: Seventh Air Force
1945–1946: Air Transport Command
1946–1949: Pacific Air Command
1949–1955: Military Air Transport Service
1955–1957: Far East Air Forces
1957–present: Pacific Air Forces
Geography
Hickam Air Force Base consists of 2,850 acres (11.5 km2), valued at more than $444 million. It was originally bounded on the north by Pearl Harbor Naval Shipyard, on the west by the Pearl Harbor entrance channel, on the south by Fort Kamehameha, and on the east by the airport complex. The original main gate is reached via Nimitz Highway (Hawaii Route 92) from Honolulu, and it shares its western terminus with the Pearl Harbor Naval Shipyard's main gate. This part of Nimitz Highway can be reached from the expressway Interstate H-1 (Exit 15) southeast from Halawa or west from Honolulu (Exit 15B) and from Kamehameha Highway (State Hawaii Route 99), the eastern termination of which is at Nimitz Highway.
The housing around the base is within the Hickam Housing CDP.[12]
Delta Connection (Operated by Republic Airways) flight 5636 departing from Norfolk International Airport (ORF) en rote New York LaGuardia Airport (LGA). Embraer E175LR.
@dailyshoot Make a photograph that illustrates the idea of connection. #ds468
The connection between my favourite lens; my Canon 50mm f/1.8 EF II and my Canon EOS 500D taken with my second favourite lens, my EF 100mm f/2.8 Macro USM lens.
Strobist info: Jessops 360AFDC 1/16 @ 85mm with CTB gel subject right. Yongnuo YN460-II 1/64 with CTO gel above and slightly behind subject aimed at contacts. Canon 430EX II 1/64 @ 105mm behind subject at same height with gridded snoot providing raking light across the top of the lens.
"Yhteys" / "Connection" - Sculpture by Essi Korva.
Oh, and the man is an additional element that I thought would give something more to this photo, something for "her" to look at, creating another kind of connection.
This book concludes our tandem edition on Recombination and Meiosis. Subtitled Models, Means and Evolution, it follows its first-born twin with emphasis on Crossing-Over and Disjunction. In the commissioning of chapter topics we have tried to cover numerous aspects of the meiotic system from many different angles. Both these books are embedded as volumes 2 and 3 in a topical Series devoted to Genome Dynamics and Stability, where DNA transmission and maintenance functions are discussed from experimental and theoretical perspectives. The earlier vol. 1 dealt with Facets and Perspectives of Genome Integrity, focusing on DNA damage repair mechanisms, and an upcoming vol.4 is on transposable elements. These books on meiotic processes, together with other volumes in this Series on genome management in mitotic cells, provide a grass-roots level starting platform—initiating a prospective trajectory superimposable upon the exploding field of molecular cell physiology, or systems biology (see below). The preceding volume preferentially dealt with meiotic processes in multicellular organisms, such as plants and animals including man. Also, basic accomplishments from work on yeasts was presented in a comparative perspective—concerning the decisive roles of Spo11-induced breaks for crossing-over, of sister chromatid cohesion in chromosome disjunction, and cell cycle modulation in the global control of the meiotic program. The present book puts additional focus on yeasts as unicellular model organisms, where progress in revealing the mechanisms of meiotic recombination has taken place most rapidly and systematically. Also, a central aspect of genetic recombination in E. coli is included for its outstanding merits as a universal model. Furthermore, three facets of evolutionary relevance are also discussed. As for the models and means of meiotic recombination, two prominent and comprehensive chapters call for particular attention. Inasmuch as theoretical interpretations of empirical data about the exchange of genetical markers in successive generations has long preceded their biochemical elucidation,James E.Haber gives expert guidance on a veritable tour de force, presenting the Evolution of Recombination Models frompurely genetic crosses into the molecular era. He follows the historical record from simplistic breaking/joining schemes to break-induced replication, from suspected single-strand breaks to partner choice by single-strand annealing, and from the generation of double-strand breaks (DSBs) to their repair by the establishment and resolution of single or double Holliday junctions, and finally to DSB repair in the absence of crossing over accomplished through synthesis-dependent strand annealing that does not involve Holliday junctions. This scenic ride is aptly complemented from the enzymatic perspective, as displayed by Kirk T. Ehmsen and Wolf-Dietrich Heyer on the Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates. These authors highlight the biochemistry of meiotic recombination, as more and more meiosis-specific enzymes have been added to the basic toolbox, which likewise is at work in mitotic cells (cf. GDS vol. 1, this Series). Overlapping with functions in replication and DSB repair these enzymes comprise topoisomerase, nuclease, recombinase, polymerase, and helicase activities, as well as single-strand stabilizing protein, a protective end-tethering complex and a range of modulating co-factors. The single most remarkable feature about the initiation of meiotic recombination is the deliberate and catalyzed introduction of numerous DSBs in the chromosomal DNA. Notably, the enzyme responsible for this pivotal and conserved activity is derived from a former topoisomerase (Spo11; Keeney, this SERIES), which as such had a cell-intrinsic function essential for the untangling of replication intermediates in every cell cycle. The total number of cuts is even larger than the number of effective crossovers later on2. The important question of how the sites to be cut are chosen in a given cell— among myriads of potentially equivalent sites that are ignored—is still one of the most vigorously pursued aspects of ongoing research. Foremost, the susceptible substrate for meiotic DSBs is not naked DNA, but DNA embedded in chromatin, as highlighted by Michael Lichten, in his chapter on Meiotic Chromatin—the Substrate for Recombination Initiation. The two yeasts compared for this traits how pronounced differences in the distribution of hotspot sites for DSB formation. In Saccharomyces cerevisiae, a fairly promiscuous DSB machinery can be assembled at about every stretch of accessible chromatin that has been opened up for other purposes, especially at activated promoter regions. Michael Lichten coins the term "opportunistic DSBs" for these phenomena, foremost in S. cerevisiae—differentiating meiotic DSBs from both lower
and higher degrees of sequence specificity: on one hand ionizing radiation induced DSBs,which occur with little sequence preference and without regard for chromatin structure, and on the other hand from the site-specific cuts of restriction-type endonucleases—or other nucleic acid transactions, such as transcription promotion, where both chromatinstructure and the recognition of DNA sequence elements contribute to specificity. Such opportunistic usage of promoter-modulated open chromatin can only in part explain the DSB pattern observed in the fission yeast Schizosaccharomyces pombe, where other determinants may play a significant, hotspot-specific role. Also to be determined by meiosis-specific chromatin organization, the assembly of and/or cleavage by the DSB machinery should not be all too promiscuous on a particular issue, in that at most one of two sister chromatids can become susceptible at any given site, whereas the other sister strand needs to be protected around the equivalent site. The molecular basis for this significant restriction still remains to be determined. After the meiosis-specific, Spo11-induced DSBs have been processed to protruding 3 ends, these single strands have to interact with the corresponding sequence on the homologous chromosome, in order to repair and seal the break by homologous recombination. In eukaryotes the crucial strand exchange reaction is catalyzed by RecA-like recombinases of the ubiquitous Rad51 family and/orthemeiosis-specificDmc1protein. As modeled by the most widely studied RecA recombinase of E.coli, Chantal Prévost, in herchapter on Searching for Homology by Filaments of RecA-Like Proteins, discerns their basic functions in the genome-wide search for complementary DNA strands so as to facilitate the initial strand exchange reaction in highly coordinated, helical DNA–protein filaments, which likewise are formed by the eukaryotic RecA homologs. Corresponding studies to the leading work on meiosis in S.cerevisiae have also been pursued in S.pombe,showing striking differences indetail at various levels. The most interesting aspects of this work are pointed out in two chapters specifically devoted to the fission yeast. For one thing, S. pombe belongs to the rather few organisms that have lost the ability to form synaptonemal complexes in meiotic prophase, which usually stands out as the most characteristic structural basis of bivalent synapsis. Instead, another conserved feature of canonical meiosis, the clustering of telomeres in the so-called bouquet arrangement, is vastly exaggerated in a series of nuclear movements, which in S. pombe facilitates a dynamical alignment
of homologous chromosomes from nuclear fusion throughout the entire prophase of meiosis (D.Q. Dingand Y. Hiraoka, this BOOK). Furthermore, the crossover mechanism itself is peculiar as well. Whilst many organisms including S. cerevisiae actually employ two partly overlapping crossover pathways, one of these pathways is entirely missing in S. pombe. Characteristically, the main recombinational intermediate in S.pombe consists of single Holliday junctions (G. Cromie and G.R.Smith, this BOOK), whilst earlier results on S. cerevisiae had suggested double Holliday junctions as the canonical model. The species-oriented chapter by Gareth Cromie and Gerald R. Smith, on Meiotic Recombination in S. pombe: A Paradigm for Genetic and Molecular Analysis,was published Online FirstinJune2007. At thatrelatively early date, most of their extensive data on DSB hotspot distribution in S. pombe were mentioned in brief as unpublished results. These significant data are now more fully discussed, as mentioned above, in Michael Lichten’s comparative chapter—with due reference to their recent publication in the mean time (Cromie et al. 2007). Unfortunate as such asynchrony appears to be, this is a price to pay for the advantages of Online First publication for the individual chapters as they are being completed—with a spread of Online First dates up to a year per book in such a series. Three evolutionary topics relating to meiosis have been selected to conclude this book: the putative origin of the meiotic system, the confinement of meiosis to the germline in animals, and the abandonment of meiosis in relatively few eukaryotic lineages, some of which are remarkably persistent on the evolutionary time scale—capable of lasting for millions of years. At the dawn of genetics, crossing-over and meiosis had been considered very much the same, but the early view of apparent congruence between the two phenomena has long since been abandoned. Instead, genetic recombination as such has proved to have much earlier and more fundamental roles than the complex and highly integrated pattern of mainstream meiosis, of which crossing-over has become the most characteristic ingredient. In short, homologous DNA recombination has directly co-evolved with faithful replication (see R. Egel and D.Penny, thisBOOK), clearing physical damageand/or broken replication forks as they arise (C. Rudolph, K.A. Schürer, and W. Kramer, GDS vol. 1, this Series)—potentially in each cell cycle of prokaryotes and eukaryotes alike. Of more sporadic occurrence, on the other hand, meiosis only happens once per generation,or life cycle—whatever meaning may be attached to these derived terms for unicellular organisms (see below). N.B., bacteria and archaea are proficient in recombinational repair of DSB damage to their DNA, but meiosis is missing altogether. In multicellular organisms, the meanings of generation and lifecycle are evident, and the complex inter-relationship of germline development and maintaining sexuality in animals and plants was already recognized by Charles Darwin and August Weissmann by the end of the 19th century. In his chapter on The Legacy of the Germ Line—Maintaining Sex and Life in Metazoans: Cognitive Roots of the Concept of Hierarchical Selection, Dirk-Henner Lankenau follows the germline concept to its historical roots, and he addresses the multiple levels of selective evolution related to this concept. Also, he fathoms Weismann’s prescient usage of germ plasm in its original meaning that nowadays has been replaced by genes and genomes—and he sketches a tie to modern frontiers, discussing the so-called nuage as a germline-specific germplasm organelle of multiple RNA processing, where a suspended term is thus revived in new guises. A hallmark of meiosis is the production of recombinant offspring, efficiently scrambling the parental genotypes. The overwhelming majority of taxonomic groups throughout eukaryotes show proficiency of meiosis, at least to begin with. Higher plants and animals would probably never have originated without the evolutionary thrust empowered by meiosis. Yet, sexual propagation including meiosis has been lost repeatedly in evolution, although major evolutionary innovations have never sprung from such secondarily asexual lineages. Hence, asexual lineages of relatively ancient origins can serve as virtual mirrors to reflect the evolutionary importance of meiosis in the remaining majority of animals and plants, as thoroughly discussed by Isa Schön, Dunja K.Lamatsch,
and Koen Martens in their chapter on Lessons to Learn from Ancient Asexuals. To single out a particular highlight, the purging of deleterious mutations by a meiotic recombination appears to be remarkably effective—readily compensating for the low mutation rates observed. As for the inferred origin of the meiotic system, this does not only far predate the emergence of multicellular animals, fungi and plants—it even dates back before the last common ancestor of all the eukaryotic phyla known today (LECA). As canonical meiosis, therefore, is a common heritage to all eukaryotes, there are no comparative cues among different lineages living today from which by parsimony to deduce a likely order of step-wise additions to the basic toolbox of meiotic mechanisms. On the other hand, the meiotic system is so complex in its widely conserved pattern, that its instantaneous invention from scratch appears unlikely. Against this rather uninformative backdrop, Richard Egel and David Penny, in their chapter On the Origin of Meiosis in Eukaryotic Evolution, propose a possible series of incremental steps towards meiosis, each of which could have added some selective advantage on its own. This series may well have started before the mitotic division system had been perfected to its present fidelity, e.g. when telomere-directed chromosome movements may have preceded the establishment of centromeres. Hence their hypothesis is subtitled Coevolution of Meiosis and Mitosis from Feeble Beginnings. A likely driving force to establish a proto-meiotic system—alternating with proto-mitotic nuclear division—is seen in maintaining a periodically needed dormancy program, so as to protect it against the accumulation of dormancy-deficient mutations at the higher error load presumed in early evolution. This is in line with the common correlation between meiosis and the formation of dormant spores or cysts in extant microbial eukaryotes. In a certain sense, therefore, a single generation in the life cycle of unicellular eukaryotes would last from one stage of encystment or sporulation to the next. With the commissioning and presentation of the various chapter topics on the genomic aspects of the meiotic system we hope to have served a salient need for integrating basic knowledge gained from studying diverse genetic model organisms. Research on meiotic exchange and segregation mechanisms may appear more esoteric than the vast resources spent on understanding metabolism and growth in mitotic cells. While emphasis on the latter area is motivated by the numerical predominance of mitotic divisions, as well as the direct connection of mitotic cell divisions to the immense problems of cancerous growth in human disease, meiosis in its paucity is more secluded and its medical aspects are limited to less pressing problems, such as impaired fertility or Down-like syndromes (H.Kokotas,M.Grigoriadou,andM.B.Petersen, this Series). Also, a certain twist of hierarchy is undeniable: whilst endless perpetuation of mitotic divisions can be viable as an evolutionarily stable strategy, a contiguous series of several meioses is certainly not. In this sense meiosis will always be the subordinate companion of mitosis. At the conceptual level, however, the complexity of molecular mechanisms applying to meiosis far exceeds that of its mitotic counterpart. And for the continuity of generations in most eukaryotic forms of life, both meiosis and mitosis are complementary features of general and essential interest. Traditionally, the largest share of meiotic research has been focused on DNA exchange and related features, whereas the immense field of protein–protein interactions in the rewiring of the meiotic cell out of and back into the mitotic cell cycle stood in second place. The concluding chapter of the preceding volume specifically deals with these meiotic aspects of molecular cell physiology (L. Pérez-Hidalgo, S. Moreno, and C. Martin-Castellanos, this Series). As pioneered with yeasts, genome-wide expression studies have started with identifying all the genes upregulated in meiotic cells and sorting them into functional categories. This is a long way off fromknowing all their particular functions. To illustrate the scope of the barely charted field: of 4,824 annotated genes in S. pombe, 955 proteins contain coiled-coil motifs4; of these, 180 are upregulated before, during or after meiosis—21 exclusively so, but not expressed during mitosis (Ohtaka et al. 2007). The interactive potential of so many proteins is enormous, and the systemsbiology of meiosis has merely just begun. To form a link between both books on Recombination and Meiosis, the list of chapter titles in the preceding volume is included after the Contents table of this book. In fact, as some of the individual chapters already had been published Online First, before the editorial decision to divide the printed edition into two books, the preliminary cross references had not yet accounted for the split. We apologize for any inconvenience this may cause, but the listing of all the chapter titles in both books should hopefully direct the reader to the proper destination. We would also like to point out that the missing chapter numbers are no neglect but reflect an obligatory compromise necessitated by publishing all manuscripts OnlineFirst immediately
after they have been peer-reviewed, revised, accepted and copy-edited (see, www.springerlink.com/content/119766/). We most cordially thank all the chapter authors for contributing to this topical edition of two accompanying books focusing on meiotic recombination. Without their expertise and dedicated work this comprehensive treatise would not have been possible. Receiving the incoming drafts as editors, we had the great privilege of being the first to read so many up-to-date reviews on the various aspects of meiotic recombination and model studies elucidating this ever-captivating field. Also, we greatly appreciate the productive input of numerous referees, who have assisted us in thriving for the highest level of expertship, comprehensiveness, and readability. We are again deeply indebted to the editorial staff at Springer. We would especially like to mention the editor Sabine Schwarz at Springer Life Sciences(Heidelberg), the deskeditor Ursula Gramm (Springer,Heidelberg),and the production editor Martin Weissgerber (le-tex publishing services oHG, Leipzig).
April 2008
Copenhagen, Richard Egel
Ladenburg, Dirk-Henner Lankenau
Happy Birthday to all!
On this day in 1818, Emily Bronte was born, in 1938, the first edition of the Beano was published, and in 1958 Kate Bush was born.
So - Beano and Wuthering Heights connections > both reading material, and of course Kate Bush and Wuthering Heights. Now, just to find a link between KB and the Beano.......
And the pencils? A reminder we took part in the project to create a written manuscript of Wuthering Heights, when we visited the Parsonage. One line each, out of 10,000 (the project is now complete).
10/26/15 photo by Stephen Schatz, Office of Communications
Secretary Belton, Senator Ben Cardin and Rick Yount, Executive Director of the Warrior Canine Connection listen to personal stories on how veterans recovered through the support and training of dogs.
Delta Connection (Operated by Endeavor Air) flight 5181 arriving at Raleigh-Durham International Airport (RDU) from Newark Liberty International Airport (EWR). CRJ-900LR.
day 91::365::04/01/2011
100 words ~ connection
I couldnt think of a better way to kick off another month than with pieces of prepping dinner for my family. I love our Friday night dinners because it's one of two nights we clear our schedules and sit down to eat together. I love that we talk about our week, what we are thankful for and that everyone here, not just me looks forward to it. As the kids get older and busier they still make sure they are here for Thankful Friday and Pasta Sunday's. As a family we choose start and end the week together. Yep, I love our conversations over dinner as it keep us connected physically and emotionally. Life is SO good!
objectivity: judgment based on observable phenomena and uninfluenced by emotions or personal prejudices.
GM built 2062 027 rolls into Klostar with the 07.02 from Varazdin to Osijek passing railbus 7221 021 which has just arrived with the 06.43 stopping service from Krizevci. Most of these class 7221 railcars were destroyed during the Balkan war with lines of gutted body shells to be seen at Osijek depot.