straining photos on Flickr

- Here are some clips clip from Paul Verhoeven´s classic satirical anti-fascist anti-american film Starship Troopers (1997) that these days somehow seems like it could be a contemporary «documentary» from Israel… and USA.

A movie everyone should see again.

«Service guarantees citizenship! Would you like to know more?»

Starship Troopers: Propaganda (1997)

ISRAEL IS NOT A DEMOCRACY [Listen here]

by Chris Hedges (b. 1956), The Real News Network January 5, 2024

Israel's status as a bona fide democracy is often taken to be a self-evident truth, but a more critical look at the history and reality of Zionism calls this into question. After all, how can a democracy exist in a country constitutionally defined as an ethnostate that can only exist through the suppression and gradual elimination of its Others? Israeli historian Ilan Pappé joins The Chris Hedges Report for a discussion on Israel as an inherently colonial, and therefore anti-democratic, project.

Ilan Pappé (b. 1956) is a professor with the College of Social Sciences and International Studies at the University of Exeter in the UK, where he directs the European Centre for Palestine Studies, and co-directs the Exeter Centre for Ethno-Political Studies. Prior to coming to the UK, Pappé was a historian and politician in Israel. He is the author of several books, including The Ethnic Cleansing of Palestine.

Studio Production: Cameron Granadino, Adam Coley

Post-Production: David Hebden

TRANSCRIPT

The following is a rushed transcript and may contain errors. A proofread version will be made available as soon as possible.

Chris Hedges:

The scholar, Yeshayahu Leibowitz (1903-1994), who Isaiah Berlin (1909-1997) called the conscience of Israel, warned that, "If Israel did not separate church and state, it would give rise to a corrupt rabbinate that would warp Judaism into a fascistic cult. Religious nationalism is to religion what National Socialism was to socialism," warned Leibowitz, who died in 1994. He understood that the blind veneration of the military, especially after the 1967 war that captured the West Bank and East Jerusalem was dangerous and would lead to the ultimate destruction of democracy. "Our situation will deteriorate to that of a second Vietnam, to a war and constant escalation without prospect of ultimate resolution," he wrote.

He foresaw that, "The Arabs would be the working people and the Jews, the administrators, inspectors, officials and police; mainly secret police. A state ruling a hostile population of 1.5 million to 2 million foreigners would necessarily become a secret police state. With all that implies for education, free speech and democratic institutions. The corruption characteristic of every colonial regime would also prevail in the state of Israel. The administration would have to suppress Arab insurgency on the one hand and acquire Arab Quislings on the other. There is also good reason to fear that the Israeli Defense Force, which has been until now, a people's army would, as a result of being transformed into an army of occupation to generate and its commanders who will have become military governors, will resemble their colleagues in other nations." He warned that the rise of virulent racism would consume Israeli society. He knew that prolonged occupation of the Palestinians would spawn concentration camps for the occupied, and that in his words, "Israel would not deserve to exist and it will not be worthwhile to preserve it."

The decision to obliterate Gaza has long been the dream of Israeli fanatics, heirs of the fascistic movement led by the extremist Meir Kahane (1932-1990), who was barred from running for office and whose Kach Party was outlawed in 1994 and declared a terrorist organization by Israel and the United States. These Jewish extremists who today make up the ruling coalition government are orchestrating the genocide in Gaza, where hundreds of Palestinians are being killed or wounded a day. They champion the iconography and language of their homegrown fascism. Jewish identity and Jewish nationalism are the Zionist versions of blood and soil. Jewish supremacy is sanctified by God as is the slaughter of the Palestinians who are compared to the biblical Amalekites massacred by the Israelites. Enemies, usually Muslims, slated for extinction are subhuman who embody evil. Violence and the threat of violence are the only forms of communication those outside the magic circle of Jewish nationalism understand. Millions of Muslims and Christians, including those with Israeli citizenship, are to be purged.

Joining me to discuss what the occupation of Palestine has done to Israeli society and what the results of the current murderous campaign in Gaza and the West Bank portends for Israel in the future is Ilan Pappé, Professor of History of the University of Exeter in Great Britain, who has described what Israel does to the Palestinians as incremental genocide. He has written numerous books including The Biggest Prison on Earth: A History of the Occupied Territories and The Ethnic Cleansing of Palestine, which his French publisher has ceased publishing despite a surge in sales since the October 7th attacks, part of the concerted campaign by Zionists and their supporters to discredit and censor narratives that are critical of Israel.

I'd like to begin with a look at post Israel, the Zionist project that begins in the 1920s, and see whether the project itself, even before the creation of the state of Israel had built within it the seeds of its own destruction.

Ilan Pappé:

Yes, I do think it did. And you are right in pointing to the 1920s because of course the Zionist movement existed before, but I think it's in the mid-1920s when it started to purchase land and evict the people who were living on that land. And that happened around 1926. It became a settler colonial project and not just a project for salvaging Jews from anti-Semitism or a national cultural redefinition of Judaism as nationalism instead of as religion.

The moment that happened, it was very clear that it's going to impose itself by force on an indigenous native population. And it was not just the classical settler colonial imposition of settlers from abroad imposing themselves on a native population, it also was kind of creating this idea that they can produce or establish a European state in the midst of the Arab world, very much like the white supremacists in South Africa. And there's two facts, that you are trying to implement a project of displacement and replacement of an indigenous population and that you are trying to create a cultural political entity that would alienate the area it belongs to and the area would alienate you were sold, I think had been sold in the 1920s. And we can see the effect of this to our days, no doubt.

Chris Hedges:

And yet there was always a tension within the Zionist project. I, you may have known him too, I knew Abba Eban (1915-2002), Teddy Kollek (1911-2007). When I was in Israel, they outlawed Meir Kahane's Kach Party. The people around Netanyahu now are of course the heirs to the Kach Party, later assassinated, this very right wing rabbi. And I want you to talk about that tension because it was there. I mean, Teddy Kollek when he was mayor of Jerusalem, when I was there, he was building sewer systems for... it was a different approach to colonization, or perhaps I have that wrong?

Ilan Pappé:

It was a different approach, but it remained colonization. If I'm a bit more abrupt about it, I would say that there was definitely an ideological stream within Zionism that believed that you could be a progressive colonizer or an enlightened colonizer. And yet from the colonized people's point of view, even if you provided some benefits in economic terms, in infrastructural terms, the colonization was still there. And the colonization was translated not only in terms of whether you provide sewages for Jerusalem or not, but by the fact that Teddy Kollek as the mayor of Jerusalem oversaw the ethnic cleansing of quite a large number of Palestinians from East Jerusalem in order to make space for building new Jewish neighborhoods, which should rightly be called Jewish colonies or settlements.

So in the end of the day, the Zionist vision, even in its most liberal version, meant that the Palestinians at best, at best could be tolerated as individuals in limited spaces within Palestine. That would be determined according to the Israeli notions of national security. And at worst, they're an obstacle that has to be removed. And as the time went by, most of the Israeli Jews said, "Why just be content with limiting their presence? Why not get rid of them altogether?"

Chris Hedges:

And yet these figures represented a secular strain of Zionism. And I want you to talk a little bit about Yeshayahu Leibowitz, who you knew, who I quoted it in the introduction, and he talks about this religious strain within Zionism where the land itself becomes sacred as particularly dangerous, I think he even uses the word fascistic. There is that split. And of course those of us, Abba Eban spoke better English than I did, Oxford educated, urbane. And so talk a little bit about that tension between secular and religious Zionism. And of course ultra orthodox religious Zionism has essentially proved triumphant.

Ilan Pappé:

Yes, I call this tension, which you rightly point to, the struggle between the State of Israel and the State of Judea. The State of Judea grows up among the national religious groups and becomes particularly potent after '67 and it's kind of headquarters, it's habitat if you want, the settlements in the West Bank, and before that, even in the Gaza Strip. And they become a force to reckon with and they combine exactly what Leibowitz was talking about, and he saw it in the making. I mean I say it in hindsight, to his credit, he saw it and kind of predicted it happening, but now we have the benefit of time to see that he was absolutely right.

So that State of Judea, what you can call the settler state, is a combination of a messianic kind of Zionism combined with fundamentalist interpretation of Judaism, a wish to create a theocracy in which also secular Jews are the enemy, not just the Palestinians. And they become stronger. They used to be on the margins and we used to think that they are not really relevant, but now they are a central power in Israel. And against them stands the State of Israel. That is the kind of pre '67 Israel that wanted to be a liberal democracy, a pluralist, secular, but is losing it in the struggle against the State of Judea.

But what is so interesting and frustrating about this struggle, it does not concern the Palestinians at all. As you probably know, and we forgot it because of the dramatic events that occurred after 7th of October, but until the 7th of October, we witnessed in Israel a kind of a mini civil war between those two states that I'm talking about, the State of Israel and the State of Judea when hundreds of thousand of secular Israelis demonstrated daily trying to defend the kind of Israel they want. But when Palestinian citizens of Israel ask them, "Can we join you? And can we also include a rejection of the occupation as part of our struggle for a better Israel?" They were chucked out of this movement of protest because it was not against the occupation, it's not against the semi apartheid or full apartheid of Israel, depends where it is. It is what kind of an apartheid Israel should we have? A liberal democratic one for the Jews or a theocratic one for the Jews?

But unfortunately it does not evolve around the main issue, the most important issue that we started our conversation with, that can you impose yourself militarily and violently on millions of people against their will?

Chris Hedges:

I want to talk about 1948, this is the war of independence. All settler colonial projects are implanted by violence as was the one in the United States. The difference is that I think by 1600, over a 100-year period, 56 million indigenous inhabitants in North, Central and South America were obliterated through either diseases or violence so that by 1600 you only had about 10% of the original indigenous population was there. That wholesale extermination essentially allows a settler colonial project to survive because there's physically no opposition. That's not true in Israel. You have about 5.5 million Palestinians living under occupation, 9 million living in the diaspora. This from the establishment of the state of Israel is a huge problem for Israeli leaders. How are they going to cope? The demographic time bomb is real in terms of Arabs having larger families. You have huge flight, a kind of brain drain from Israel. I think there's a million Israelis living in the United States. But let's look at 1948, how they deal with a problem. And then we'll go to 1967 when Israel occupies what is the remaining part of Palestine, the West Bank and Gaza.

Ilan Pappé:

Yes, as you rightly say, settler colonial projects have always these two dimension, geography and demography, or if you want space and population, you want the space without the population. And the more space you take, the more unwanted population you have. So the Zionist leadership exploited the end of the mandate, the circumstances that developed in the region and in the world three years after the Holocaust to implement a massive ethnic cleansing that left half of the Palestinian refugees and expelled half of the Palestinian population, destroyed half of the Palestinian villages, more than 500, and demolished most of the Palestinian towns.

So within the borders that were kind of established after 1948, that is Israel today without the West Bank and the Gaza Strip, Israel was unable to fully complete the ethnic cleansing, but it had a relatively small Palestinian minority that did not endanger the demographic majority of the Jews. So you could even have a demographic state because you always knew that democracy and demography would go hand in hand. Although because of the paranoia of Ben-Gurion until 1966, although the Palestinians in Israel had the right to vote and to be elected, they were under a very harsh military rule as it is.

Now, it's not surprising that David Ben-Gurion (1886-1973), the big architect of the ethnic cleansing of 1948, was trying to pressure the government of Israel. He was out of effective politics already in 1963, but he was trying after June '67 to convince the Israeli government to get out of the West Bank, almost saying to them, "I was able to get rid of about 1 million Palestinians, and now you are incorporating even a larger number of Palestinian under your rule." The kind of leadership that followed him, some of them were young generals during the '48 war and some other politicians like Levi Eshkol (1895-1969) and you mentioned also Abba Eban and Teddy Kollek, they decided there is no need for massive ethnic cleansing in order to keep the demography in such a way that it doesn't endanger the Jewish democracy.

So what did they do? They decided to keep millions of people in the West Bank and the Gaza Strip without the right to take part in the Israeli political system. When some people said to them, "Okay, that's fine, but can you in return give the Palestinian the right to determine their future in a Palestinian state in the West Bank and the Gaza Strip?" They didn't accept that either. So they really believed that they could somehow contain the Palestinian national ambition and resistance within that idea of a West Bank and a Gaza Strip that is our enclave controlled by Israel, maybe with some autonomy for the Palestinian inside, and convince the world that this is the best solution and even call it a kind of a two-state solution. Of course, it had nothing to do with a two-state solution.

So historically speaking, it's the same problem all the time, as you rightly say, Chris, it's having the territory without the people, but because of circumstances and things that changed, '48 is not '67 and '67 is not 2023, and because of that, the methods of maintaining this balance between territory and population changes. But the vision is the same one, and the purpose is the same one, and the failures are the same one. The massive expulsion didn't work. The idea of keeping people without citizenship rights is not working, and even putting them under siege as we have seen on the 7th of October is not working. And whatever the Israelis have in mind for Gaza, I can assure you, without knowing how it would unfold, it's going to be a huge failure, which unfortunately will have an incredible human cost, mainly for the Palestinians.

Chris Hedges:

Leibowitz really takes the 1967 war, which sees Israel seize the remaining land by Palestinians as the dividing point. He defines himself as a Zionist. He seems to argue that the pre 1967 borders known as the Green Line could work. But '67 for him and the refusal on the part of the Israeli leadership to give up the occupation, or after '67, move back to the pre '67 borders, really, he argues quite passionately is in many ways the death now of Israeli democracy, civil society. Can you explain that?

Ilan Pappé:

Yeah. Well, first of all, I would say that I think that as we started our conversation, the seeds for this end or implosion from within had been sold much earlier in the 1920s. But let's go along with this thesis, although I think it was doomed to fail from the very beginning. But there's no doubt that the occupation of 1967 accelerated these processes by which you had a legal system, a political system, and the culture system that justified a daily violation of the human rights and the civil rights of the Palestinians, at least inside Israel. In the pre '67 Israel, there was an attempt all the time to improve the situation of the Palestinian citizens in Israel. And as we said, they had the right to vote, they had the right to be elected, and finally they even were allowed to create their own national parties and so on.

But at the same time, the direction in the West Bank and the Gaza Strip was going towards a different kind of a future, a long and never ending building of two mega prisons, one in the West Bank and one in the Gaza Strip maintained by at least hundreds of thousands of Israeli had to be daily involved in maintaining this mega prison of policing millions of people. And the idea, and I think that's where Leibowitz, which was different from Kollek and Abba, even for instance, Leibowitz warned them that their sense that they might separate, there will be this democratic liberal pluralist Israel within the pre '67 borders, and there will be something less admirable, less fortunate, but hopefully manageable beyond the Green Line, beyond the borders of Israel. And he warned rightly so that you will not be able to contain it, that it would spill over into Israel, and you will not have, in the end of the day, two entities, namely a liberal democratic Israel next to an occupied Palestine.

No, in the end of the day, you will have one apartheid system that may have varieties in the way it controls the lives of Palestinians, but in essence, as indeed Human Rights Watch and Amnesty International eventually understood recently, would have to be ruled through segregation, discrimination, and oppression. And it doesn't matter whether we talk about Tel Aviv and Haifa or we talk about Nablus and Gaza, it became one organic country where the people who are Palestinians are subjected to a variety of legal regimes and military regimes that violate the basic civil and human rights.

Chris Hedges:

And I just want to say that Israeli Arabs, even though pre '67 there were moves to incorporate them in the side, nevertheless did not serve in the army or the intelligence units. That's correct, right?

Ilan Pappé:

Yeah, yeah.

Chris Hedges:

Yeah. So Leibowitz, it's not just that the occupation for him is not sustainable, but it's what it does, how it deforms Israeli society. And I wonder if you could speak to what happened. I'm especially interested in why you believe these Zionist fanatics and bigots and crypto-fascists, these people surrounding Netanyahu, why they became ascendant?

Ilan Pappé:

Well, I think that there are two crises here at work. One crisis is what you can call the Zionist left, this attempt to, if you want, to square the circle to somehow say to yourself, I can be both an occupier and a socialist or a liberal. This failed to work on so many levels. First of all, the Palestinians were not impressed by that. They understood, as I once put it, that when a Zionist has a boot on your face, it doesn't matter whether he holds the Book of Marks or the Bible, what matters is the boot. And I think that's one reason the Zionist left was not working. Secondly, there was a sense among the Israeli Jewish electorate that this is a deception actually. And there was something in it, they said, "You actually think like us, but you would've liked it to be nicer. You would've liked the world not to be fully aware of it. You don't want to lose international legitimacy. It's not because you have different moral approach, but you have a more functional approach to it." And that did not convince the Jewish electorate.

So one crisis was this, what I call the failure to square the circle and take universal values and say that they can coexist with the values of colonialism and oppression. The second and no less important is the failure or the collapse of the idea that you can redefine Judaism as nationalism. There was an attempt to create a Jewish culture, a Jewish identity, which is secular, and it didn't work. There are some successes. There is a Hebrew culture, no doubt. I myself dream in Hebrew. Hebrew is my mother tongue so I'm fully aware of the success of Zionism to create a Hebrew culture. But the Hebrew culture is not a substitute for Judaism. It creates a culture around language, but doesn't have the power that a religious affiliation has.

And what happened was that while the religious Jews had a clear idea what Judaism is, Israeli Jews never knew what does it mean to be an Israeli Jew? As you probably know, in our idea, on our identity cards, our nationality is not Israeli. No, Israeli has an nationality identity that is an Israeli. In my idea, it's written that my nationality is Jewish. And in the idea of my neighbor who is a Palestinian Israeli, it says that his nationality is Muslim, not Palestinian or Christian, which I mean, they try to impose this idea that they can play with religious identities and even impose it on Christians and Muslims. It doesn't work. It doesn't work. And I think anywhere you look at the world and attempt to create a state identity that is equivalent to a religious identity in the modern world is not working. It is not working.

And this crisis has led to the return to Judaism as a religion by many Israeli Jews, including the Arab Jews who were anyway more traditional. And then they asked themselves similar things that are happening in political Islam. Can we translate the Jewish scriptures into political documents of our day? Can we impose the imperatives of the religion on the public domain, on the state policy, both the domestic one and the foreign one? And for secular Israelis, this is something they cannot coexist with. But they don't really have a very good answer. So what does it mean to be a Jew if it's not to be a religious Jew? What is a secular Jew? What is a secular Muslim for that matter? Or secular Christian? And that's a crisis that maybe also exists in other places, but there's no, this pressure cooker that Israel is where these questions become vital and existential.

Chris Hedges:

When Thucydides (c. 460 BC – c. 400 BC) talked about the expansion of the Athenian Empire, he wrote that, "The tyranny Athens imposed on others, it finally imposed on itself." To what extent is the tyranny that Israel has imposed on occupied Palestinians now being imposed on itself?

Ilan Pappé:

Well, we had clear indications, especially... I mean, they were there before, but I think the 7th of October was a pretext for this tyranny to be directed towards freethinking Israeli citizens who are also Jewish by definition. We have a clear case of a history teacher in Petah Tikva who all he did, he shared with his students, pupils rather, some alternative views to the ones they hear in the Israeli media. And he was arrested for few days before he was released. Any attempt by Palestinian citizens of Israel or anti-Zionist Israeli citizens to express doubts or even say that you have to understand the context of the 7th of October is regarded by the police as incitement to terrorism. So inevitable, as any historian would know, this can never be contained towards one group of people, and eventually you use these powers against your own people, and it depends who is the one who uses the power.

There's some very important critical sociologists in Israel, which I am not one of them, but they followed the way that the upper echelons of the Israeli Security Service, the upper echelons of the army, are now populated by what I call the State of Judea, namely settlers, national religious settlers are now occupying very important position. You have, of course, the ultimate example, and this is the terrorist from the Judea state, Itamar Ben-Gvir (b. 1976), as the Minister of Internal Security. So even at the top, you have someone who doesn't hesitate to use the same means against free thinking Israelis, regardless of who they are, Jews or Arabs, as he wants to use them against the Palestinians. But he may be a bit of a joke even in the eyes of his own subordinates, but there are more serious people below him who supposedly are part of the civil service and are not politically elected, but they come from this ideological hotbed that sees people like myself, if you want, as dangerous as any Palestinian, and that is something that is now spreading in Israel.

Chris Hedges:

Let's talk about October 7th, both the micro impact and as a historian, the macro impact?

Ilan Pappé:

Well, the micro impact is a bizarre, really and I'm trying to get my head around it, although I can begin to understand this. Let's start with the Israeli Jewish society. There is this almost impossible mixture of total disbelief in the ability of the Jewish state to defend you or even provide you with the most fundamental services. So it's a total breakdown in the confidence of the State to provide for you, not only defend you because the military failed, but the way the state was not there after the 7th of October. I don't know how much people are aware of it, but the State did not function for about two months in terms of providing social, economical... it was all done by the civil society. The government did not function at all in terms of helping people who were evicted from the north or the south.

So on the one hand, there is this breakdown in believing in the State. On the other hand, there is a total support for the genocidal policies in Gaza. It's a contradiction, but one can understand where it comes from, and that's one of the micro kind of impact you have, that you will have an even more intransigent, inflexible, theocratic, fanatic Israeli Jew society in the post 7 October Israel.

As for the Palestinians, I think some big questions would be asked also by the Palestinian national movement because it's a big responsibility to stage an operation when you probably know beforehand what the Israeli reaction would be. It always reminds me of the two... I had a webinar with some people from Lebanon and we talked about it, and I think there are similarities. People say to me, "But Hamas was kind of building on the legacy of 2000 when Hezbollah bravely succeeded in pushing the Israeli army outside of Lebanon." So there is an example of an Arab paramilitary group being a match to the might of the Israeli Army. But I said, "Yes, but there's another legacy, that's a legacy of 2006 when Hassan Nasrallah (b. 1960), the leader of Hezbollah, said, 'Had I known that Israeli reaction to the abduction of three soldiers would be the destruction of Beirut, I would not have ordered that operation.'"

So he did talk with responsibility of when you strategize, you have responsibility also for your own people. It would be interesting to see in the micro level, first of all how the Palestinians are reacting to the Israeli retaliation, beyond of course their ability. And I think they were able to galvanize public opinion to show that however one condemns or doesn't condemn the service of October, it does not weaken the basic growing solidarity with the Palestinians.

Now let's talk about the macro. The macro is that Israel is not going to defeat the Hamas that easily, and is going to be stuck there. And in order even to maintain some sort of success, victory, they would have to stay there for years in direct occupation. And this could easily escalate into an uprising in the West Bank and attack from the north by Hezbollah, and who knows, even undercurrents in the Arab world that would change the Arab tolerance of Israel that we have seen so far. This can escalate to regional war. On the one hand, that's the bleak scenario.

The more positive scenario in the macro one is that the civil society that is now very much pro-Palestinian and even supports boycott and divestments from Israel, may succeed in convincing some governments in the Global North, and definitely in the Global South, to move beyond actions of civil society into sanctions and pressure on Israel, and maybe have a total new perception about the need to pressure Israel to give up its supremacist policies, its oppression, and so on.

It's too early to judge which of the two processes will unfold. They may even unfold in conjunction, namely, the more violent the region would become, the more willing maybe the international community would be willing to change its basic perceptions of what is the essence of the problem and what is the way out of it.

Chris Hedges:

But isn't the key Washington? I mean Israel, along with the US, is already on this issue, they're pariah states, as we saw with the vote in the UN. As long as there's unconditional support from Washington, Israel can resist any kind of pressure, can't they?

Ilan Pappé:

Well, that's a very big question because I think that the Global South also has power. I taught in a Chinese university recently in September, and it was very clear that China, for instance, is still reluctant to be involved in the question of Palestine because as you know, Chinese foreign policy, contrary to the way it's portrayed in America, is interested in economic gains more than anything else. And rightly so, Palestine is not an economic bonanza these days. So I don't think they're likely to be involved too much in it.

But I do think that there are other powers on the international map that could challenge the American hegemony on the question of Palestine, that's one point. And secondly, yes, America is still a key, but something is happening in the American civil society. Israelis and pro-Israelis in America like to call it the rise of new anti-Semitism, which is a very superficial analysis of the fact that the younger generation of Americans, A, is much more knowledgeable than the previous generation what goes on in Palestine. B, is far more committed, some people would say naively, but they are more committed to moral dimension of foreign and security policies. And that includes large chunks of the young American Jewish community. So I'm not sure that also this determinist view of an American policy is the right approach, either. I do think there's a chance of a different American policy as well.

But I do think Chris, probably the best way to do it is by saying there are two coalitions now when it comes to Palestine. One I call global Israel. Global Israel is still governments in the Global South, multinational corporation, military industries, security industries, communities of Christian Zionists and Jews who more or less continue to provide Israel immunity for almost everything it does, almost automatically, kind of a faith. And against that is global Palestine. And global Palestine is made of civil societies. Some governments in the Global South who are not only pro-Palestinian, but they really believe that the struggle for justice in Palestine connects very well with their own struggles against injustice in their own societies. And this is the younger generation of the world.

And I think that this is a battle that goes beyond a Palestine, connects ecological issues, poverty issues, rights of minorities issues with Palestine, and therefore I don't think the balance of power is just America versus the rest of the world. I think there are much more complex two global coalitions, which are relevant not only to Palestine, but I see the relevance mainly in the case of Palestine because I'm interested in it. But I'm sure they can be also exposed in other places of contention and where conflicts are still raging.

Chris Hedges:

Let's close by looking at Gaza. First I want to talk about intent. The UN says that half of Gazans now face starvation. I was in Sarajevo during the war, that was 300 to 400 shells a day, four to five dead a day, about two dozen wounded a day. This is just by comparison, I don't want to minimize what happened in Sarajevo, I still have nightmares about it. But that's nothing compared to what's happening in Gaza in terms of the level of bombing. What is the intent? Is the intent to create a humanitarian crisis of such extremity that the international community is forced to intervene and become a partner in ethnic cleansing? Well what? You know the mindset of the people around Netanyahu better than I do.

Ilan Pappé:

Well, first of all, I think that there was really here an inertia of revenge to begin with, rather than a very careful planning. And not everything should be attributed to clear and systematic planning. As the days went by, it was clear to at least one group within the policymakers who thought that the war gives a pretext to get rid of Gaza, a more systematic planning. So the end result, as far as they're concerned, is the depopulation of the Gaza Strip from as many Palestinians as possible either to Egypt or to other parts of the world, because Gaza, if it's not sustainable now, it wouldn't even be less sustainable in the future. I think there is one component among the Israeli policy makers who believe that they have the power to do it.

There is a more, I don't know, even call them more moderate, I'll call them more pragmatic people like Benjamin Gantz (b. 1959), Gadi Eizenkot (b. 1960), also depends. I mean, they joined the government in the last moment from the opposition. I don't know how influential they will be for the day after. But if they're still influential on the day after, they would like to see... They have a certain end game in mind, which is to annex part of the Gaza Strip directly to Israel, which what will remain is a very small piece of land with a huge number of people living in it and hoping that someone else would run the domestic affairs of Gaza, whether it's the PA or a multinational force.

However, they don't think that it's even possible to discuss the day after scenarios before they fulfill what they promised to the Israeli public, which is something they cannot fulfill. And that's one of the reasons for the carnage that we are seeing, that they could have this victory photo, kind of triumphant photo that shows that the Hamas is nowhere to be seen in Gaza, or at least nowhere to be seen as a military force. I don't think they can achieve it, but they still believe that they can.

And until that happens, they continue relentlessly doing it by the way, [by that, even endangering more the lives of the still 130 and so Israeli hostages still held by the Hamas in the Gaza Strip]. They claim that the two objectives of what they call the land maneuver is to destroy the Hamas as a military power and to salvage the hostages. It's very clear from the way they're acting, they have given up on the hostages, but they still believe they have the power to get this picture that they want, either a dead Yahya Sinwar (b. 1962) or an expelled Sinwar, the scenario of Lebanon 1982 Arafat leaving to Tunis with the rest of the Palestinian leadership. These are the scenarios they have, and all the means seems to be justified in their eyes to achieve that.

Chris Hedges:

And you are arguing they won't. So what happens when they don't achieve that?

Ilan Pappé:

That's what I meant before that what happens is that they are going to be stuck there for much longer than they think, involved in a guerilla warfare which is much longer than they think, endangering every day an escalation that could bring other factors as other actors into that conflict with dire consequences also for Israel itself. Can you imagine, Chris, what would've happened if in the 7th of October Hezbollah would've coordinated with the Hamas a similar attack on the north? Remember, the main military problem for Israel was that most of its army was in the West Bank helping to defend the settlers and helping them with their ethnic cleansing. So there was not enough soldiers in the North and not enough soldiers on the Gaza border to prevent a operation like the one the Hamas conducted. Imagine what would happen if the Hezbollah would've joined in, how Israel would've got out of that. And somehow this lesson is not being learned by the Israeli policymakers.

So I think that they are going to take Israel into a very dire future, even for the Israelis themselves, in terms of casualties, in terms of international isolation, in terms of economic crisis. And relying all the time on the American Congress, it's not the best and most solid pillar in the world to build a future for a younger generation and tell them that they live in the best place the Jews could be in the world right now. They're sort of digging their own hole here because they don't want to see what the problem is and what price they have to pay if they really want to build a different future.

Chris Hedges:

Great. That was Ilan Pappe, professor of history at the University of Exeter in Great Britain, author of the Biggest Prison on Earth: The History of the Occupied Territories and the Ethnic Cleansing of Palestine. I want to thank the Real News Network and its production team, Cameron Granadino, Adam Coley, David Hebden, and Kayla Rivara. You can find me at ChrisHedges.substack.com.

This article first appeared on The Real News Network and is republished here under a Creative Commons license.

Grace Strain by The Crochet Crowd

Avianaa Strain by Max Shuster

6 1

blue bounced, orange virus. hypodermic needle covers.|

MaxShuster.com | tumblr

Stráin by Kristján Haraldsson

Up hill Strain by Paul Clarke

Strain & Shields by Martin Mackillop

TXZ 6204

Richard Strain by nelottery

Richard Strain, Crete $5,000 MyDaY, March 2016

Strain by Charles Lee

strain by Tatuli Japoshvili

tatulie.wordpress.com/

The Acacia Strain by HEAVY METALSOURCE

The Acacia Strain, live at Chain Reaction on

The Acacia Strain, live at Chain Reaction on 6.14.08.

Vitesse Rouge by Mikael Colville-Andersen

5 6

Local train zipping past at speed.

a strain divine by Chris Ezelle

7 2

® 2013

Feel the strain by Barry Easton

Straining by Nathanael Handlang

Myrna Strain by nelottery

Myrna Strain of Genoa won $200,000 playing Royal Riches from the Nebraska Lottery! Myrna said she'd gone into the store to grab a pop and some Scratch tickets. When she saw how much she won she couldn't talk. Congrats, Myrna!

Repetitive Strain 106:365 2018 by Malcolm Smith

Until he is fit for active duty, Stormy's light duties appear to be centred around the data team. He thought things could not be any worse than yesterday's data transfer shift, he was wrong! Today he was helping the data entry guys. As he can't jump around like the others, he was put in charge of the space key. At least with all that bending, his abs got a workout. Stormy never thought the day would come that he longed to be back out on the battlefield.....

Strain with ease. by halcyon lee

Unknown Strain by Andrew

julie_strain_iii by Corina Chirla

6 1

Adam Strain Building by aimfree

Darien, GA

1813

Diavol Strain by Matt Carroll

Eye strain by Chris Grimwood

3 1

Kitchen strainer mesh

Llynefyrnwy Straining Tower by Keith Bellis

Groyne Strain by Smirko

6 4

Eastbourne, E-Sussex, Seafront

Boris Vallejo - Julie Strain by Corina Chirla

honey straining rig by dougjimison

So I got hit with colony collapse disorder all of my Bees died, or left. This gave us a lot more honey to extract. In stead of 10 small frames we had 10 smalls and 17 (with some empty spots) medium frames of capped honey. We tried uncapping and letting the frames sit in the hot bathroom in large black totes. the radiator got the wax so hot it started to fail but the honey did not flow out of the frames. We gave up and simply cut the comb from frames and crushed it. This made a LOT more wax to strain out of the honey. It took forever to strain. We cranked up the wood burner and got the room to over 80. in the end we got 4 gallons of honey. If we sold it we would almost pay off everything we bought for the first year of bee keeping. So we will start again next year, but with 2 hives.

The rig we used to begin with was a strainer bag from one of the Bee supply houses. Caution the elastic rips out easy. This was placed over a 5 gallon bucket, we chose one that was clear with volume markings on it. over this we placed a kitchen strainer on a rack so it would not fall in. We added a gate at the bottom of the bucket to allow the honey to be pulled off from the bottom. For the second day we grabbed a second 5 gallon bucket drilled some holes in the bottom and moved the strainer bag to it. This allowed the honey in the bottom bucket to be pulled off with out having the bag slow it down. It also allowed the bag to drain completely before it was harvested. We added a Gama seal lid ring to the top of the bottom bucket to reduce the opening and lift the top strainer bucket up closer to 1/2 way. This was done again to allow the bottom bucket to flow freely and not worry about filling up to the top strainer bucket.

A few notes:

1) do not drip honey or wax on top of the wood burner the smoke stinks.

2) Yes the most tarp you have as honey goes everywhere when you are cutting the comb out and squeezing the honey from it.

3) when you are squeezing honey form the comb make sure that your paints fit and your belt works. If you do not your will either be standing there in your shorts or counting on family to pull up your paints, and they are laughing too hard and taking pictures to help. ok, ok she only took one but this is a better story.

strain by deb

World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5) by rs Vots

_-----------------------------------------

The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021

*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety

*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)

——————————————————————————

(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021

-------------------------------------------------- ---------------------

According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.

The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.

, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent

What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of the cell. The ribosome is the place where protein biosynthesis occurs.

Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.

Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell

(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology

(2) New crown vaccine design, molecular biology and chemical structure, etc.

(3) The generality and particularity of the development of new coronavirus drugs

(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.

(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.

(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities

(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.

(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.

(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.

(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus

(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and

The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.

(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,

Hepatitis virus,

Marburg virus

Sars coronavirus, plague, anthracnose, cholera

and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.

However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.

　　　　 Delta mutant strain

According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.

At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.

(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.

(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.

And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.

, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.

Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2～8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.

(2) Live attenuated vaccine: It is a vaccine made by using artificial targeted mutation methods or by screening live microorganisms with highly weakened or basically non-toxic virulence from the natural world. After inoculation, the live attenuated vaccine has a certain ability to grow and reproduce in the body, which can cause the body to have a reaction similar to a recessive infection or a mild infection, and it is widely used.

(3) Subunit vaccine: Among the multiple specific antigenic determinants carried by macromolecular antigens, only a small number of antigenic sites play an important role in the protective immune response. Separate natural proteins through chemical decomposition or controlled proteolysis, and extract bacteria and virusesVaccines made from fragments with immunological activity are screened out of the special protein structure of, called subunit vaccines. Subunit vaccines have only a few major surface proteins, so they can eliminate antibodies induced by many unrelated antigens, thereby reducing the side effects of the vaccine and related diseases and other side effects caused by the vaccine. (4) Genetically engineered vaccine: It uses DNA recombination biotechnology to direct the natural or synthetic genetic material in the pathogen coat protein that can induce the body's immune response into bacteria, yeast or mammalian cells to make it fully expressed. A vaccine prepared after purification. The application of genetic engineering technology can produce subunit vaccines that do not contain infectious substances, stable attenuated vaccines with live viruses as carriers, and multivalent vaccines that can prevent multiple diseases. This is the second-generation vaccine following the first-generation traditional vaccine. It has the advantages of safety, effectiveness, long-term immune response, and easy realization of combined immunization. It has certain advantages and effects.

New coronavirus drug development, drug targets and chemical modification.

Ligand-based drug design (or indirect drug design planning) relies on the knowledge of other molecules that bind to the target biological target. These other molecules can be used to derive pharmacophore models and structural modalities, which define the minimum necessary structural features that the molecule must have in order to bind to the target. In other words, a model of a biological target can be established based on the knowledge of the binding target, and the model can be used to design new molecular entities and other parts that interact with the target. Among them, the quantitative structure-activity relationship (QSAR) is included, in which the correlation between the calculated properties of the molecule and its experimentally determined biological activity can be derived. These QSAR relationships can be used to predict the activity of new analogs. The structure-activity relationship is very complicated.

Based on structure

Structure-based drug design relies on knowledge of the three-dimensional structure of biological targets obtained by methods such as X-ray crystallography or NMR spectroscopy and quantum chemistry. If the experimental structure of the target is not available, it is possible to create a homology model of the target and other standard models that can be compared based on the experimental structure of the relevant protein. Using the structure of biological targets, interactive graphics and medical chemists’ intuitive design can be used to predict drug candidates with high affinity and selective binding to the target. Various automatic calculation programs can also be used to suggest new drug candidates.

The current structure-based drug design methods can be roughly divided into three categories. The 3D method is to search a large database of small molecule 3D structures to find new ligands for a given receptor, in order to use a rapid approximate docking procedure to find those suitable for the receptor binding pocket. This method is called virtual screening. The second category is the de novo design of new ligands. In this method, by gradually assembling small fragments, a ligand molecule is established within the constraints of the binding pocket. These fragments can be single atoms or molecular fragments. The main advantage of this method is that it can propose novel structures that are not found in any database. The third method is to optimize the known ligand acquisition by evaluating the proposed analogs in the binding cavity.

Bind site ID

Binding site recognition is a step in structure-based design. If the structure of the target or a sufficiently similar homologue is determined in the presence of the bound ligand, the ligand should be observable in that structure, in which case the location of the binding site is small. However, there may not be an allosteric binding site of interest. In addition, only apo protein structures may be available, and it is not easy to reliably identify unoccupied sites that have the potential to bind ligands with high affinity. In short, the recognition of binding sites usually depends on the recognition of pits. The protein on the protein surface can hold molecules the size of drugs, etc. These molecules also have appropriate "hot spots" that drive ligand binding, hydrophobic surfaces, hydrogen bonding sites, and so on.

Drug design is a creative process of finding new drugs based on the knowledge of biological targets. The most common type of drug is small organic molecules that activate or inhibit the function of biomolecules, thereby producing therapeutic benefits for patients. In the most important sense, drug design involves the design of molecules with complementary shapes and charges that bind to their interacting biomolecular targets, and therefore will bind to them. Drug design often but does not necessarily rely on computer modeling techniques. A more accurate term is ligand design. Although the design technology for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, etc., which must be optimized first before the ligand can become safe and effective. drug. These other features are usually difficult to predict and realize through reasonable design techniques. However, due to the high turnover rate, especially in the clinical stage of drug development, in the early stage of the drug design process, more attention is paid to the selection of drug candidates. The physical and chemical properties of these drug candidates are expected to be reduced during the development process. Complications are therefore more likely to lead to the approval of the marketed drug. In addition, in early drug discovery, in vitro experiments with computational methods are increasingly used to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological characteristics. A more accurate term is ligand design. Although the design technique for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, iatrogenic effects, etc., which must be optimized first, and then the ligand To become safe and effective.

For drug targets, two aspects should be considered when selecting drug targets:

1. The effectiveness of the target, that is, the target is indeed related to the disease, and the symptoms of the disease can be effectively improved by regulating the physiological activity of the target.

2. The side effects of the target. If the regulation of the physiological activity of the target inevitably produces serious side effects, it is inappropriate to select it as the target of drug action or lose its important biological activity. The reference frame of the target should be expanded in multiple dimensions to have a big choice.

3. Search for biomolecular clues related to diseases: use genomics, proteomics and biochip technology to obtain biomolecular information related to diseases, and perform bioinformatics analysis to obtain clue information.

4. Perform functional research on related biomolecules to determine the target of candidate drugs. Multiple targets or individual targets.

5. Candidate drug targets, design small molecule compounds, and conduct pharmacological research at the molecular, cellular and overall animal levels.

Covalent bonding type

The covalent bonding type is an irreversible form of bonding, similar to the organic synthesis reaction that occurs. Covalent bonding types mostly occur in the mechanism of action of chemotherapeutic drugs. For example, alkylating agent anti-tumor drugs produce covalent bonding bonds to guanine bases in DNA, resulting in cytotoxic activity.

. Verify the effectiveness of the target.

Based on the targets that interact with drugs, that is, receptors in a broad sense, such as enzymes, receptors, ion channels, membranes, antigens, viruses, nucleic acids, polysaccharides, proteins, enzymes, etc., find and design reasonable drug molecules. Targets of action and drug screening should focus on multiple points. Drug intermediates and chemical modification. Combining the development of new drugs with the chemical structure modification of traditional drugs makes it easier to find breakthroughs and develop new antiviral drugs. For example, careful selection, modification and modification of existing related drugs that can successfully treat and recover a large number of cases, elimination and screening of invalid drugs from severe death cases, etc., are targeted, rather than screening and capturing needles in a haystack, aimless, with half the effort. Vaccine design should also be multi-pronged and focused. The broad-spectrum, long-term, safety, efficiency and redundancy of the vaccine should all be considered. In this way, it will be more powerful to deal with the mutation and evolution of the virus. Of course, series of vaccines, series of drugs, second-generation vaccines, third-generation vaccines, second-generation drugs, third-generation drugs, etc. can also be developed. Vaccines focus on epidemic prevention, and medicines focus on medical treatment. The two are very different; however, the two complement each other and complement each other. Therefore, in response to large-scale epidemics of infectious diseases, vaccines and various drugs are the nemesis and killers of viral diseases. Of course, it also includes other methods and measures, so I won't repeat them here.

Mainly through the comprehensive and accurate understanding of the structure of the drug and the receptor at the molecular level and even the electronic level, structure-based drug design and the understanding of the structure, function, and drug action mode of the target and the mechanism of physiological activity Mechanism-based drug design.

Compared with the traditional extensive pharmacological screening and lead compound optimization, it has obvious advantages.

Viral RNA replicase, also known as RNA-dependent RNA polymerase (RdRp) is responsible for the replication and transcription of RNA virus genome, and plays a very important role in the process of virus self-replication in host cells, and It also has a major impact on the mutation of the virus, it will change and accelerate the replication and recombination. Because RdRp from different viruses has a highly conserved core structure, the virus replicase is an important antiviral drug target and there are other selection sites, rather than a single isolated target target such as the new coronavirus As with various mutant viruses, inhibitors developed for viral replicase are expected to become a broad-spectrum antiviral drug. The currently well-known anti-coronavirus drug remdesivir (remdesivir) is a drug for viral replicase.

New antiviral therapies are gradually emerging. In addition to traditional polymerase and protease inhibitors, nucleic acid drugs, cell entry inhibitors, nucleocapsid inhibitors, and drugs targeting host cells are also increasingly appearing in the research and development of major pharmaceutical companies. The treatment of mutated viruses is becoming increasingly urgent. The development of drugs for the new coronavirus pneumonia is very important. It is not only for the current global new coronavirus epidemic, but more importantly, it is of great significance to face the severe pneumonia-respiratory infectious disease that poses a huge threat to humans.

There are many vaccines and related drugs developed for the new coronavirus pneumonia, and countries are vying for a while, mainly including the following:

Identification test, appearance, difference in loading, moisture, pH value, osmolality, polysaccharide content, free polysaccharide content, potency test, sterility test, pyrogen test, bacterial endotoxin test, abnormal toxicity test.

Among them: such as sterility inspection, pyrogen inspection, bacterial endotoxin, and abnormal toxicity inspection are indicators closely related to safety.

Polysaccharide content, free polysaccharide content, and efficacy test are indicators closely related to vaccine effectiveness.

Usually, a vaccine will go through a long research and development process of at least 8 years or even more than 20 years from research and development to marketing. The outbreak of the new crown epidemic requires no delay, and the design and development of vaccines is speeding up. It is not surprising in this special period. Of course, it is understandable that vaccine design, development and testing can be accelerated, shortened the cycle, and reduced some procedures. However, science needs to be rigorous and rigorous to achieve great results. The safety and effectiveness of vaccines are of the utmost importance. There must not be a single error. Otherwise, it will be counterproductive and need to be continuously improved and perfected.

Pre-clinical research: The screening of strains and cells is the basic guarantee to ensure the safety, effectiveness, and continuous supply of vaccines. Taking virus vaccines as an example, the laboratory stage needs to carry out strain screening, necessary strain attenuation, strain adaptation to the cultured cell matrix and stability studies in the process of passaging, and explore the stability of process quality, establish animal models, etc. . Choose mice, guinea pigs, rabbits or monkeys for animal experiments according to each vaccine situation. Pre-clinical research generally takes 5-10 years or longer on the premise that the process is controllable, the quality is stable, and it is safe and effective. In order to be safe and effective, a certain redundant design is also needed, so that the safety and effectiveness of the vaccine can be importantly guaranteed.

These include the establishment of vaccine strain/cell seed bank, production process research, quality research, stability research, animal safety evaluation and effectiveness evaluation, and clinical trial programs, etc.

The ARS-CoV-2 genome contains at least 10 ORFs. ORF1ab is converted into a polyprotein and processed into 16 non-structural proteins (NSP). These NSPs have a variety of functional biological activities, physical and chemical reactions, such as genome replication, induction of host mRNA cleavage, membrane rearrangement, autophagosome production, NSP polyprotein cleavage, capping, tailing, methylation, RNA double-stranded Uncoiling, etc., and others, play an important role in the virus life cycle. In addition, SARS-CoV-2 contains 4 structural proteins, namely spike (S), nucleocapsid (N), envelope (E) and membrane (M), all of which are encoded by the 3'end of the viral genome. Among the four structural proteins, S protein is a large multifunctional transmembrane protein that plays an important role in the process of virus adsorption, fusion, and injection into host cells, and requires in-depth observation and research.

1S protein is composed of S1 and S2 subunits, and each subunit can be further divided into different functional domains. The S1 subunit has 2 domains: NTD and RBD, and RBD contains conservative RBM. The S2 subunit has 3 structural domains: FP, HR1 and HR2. The S1 subunit is arranged at the top of the S2 subunit to form an immunodominant S protein.

The virus uses the host transmembrane protease Serine 2 (TMPRSS2) and the endosomal cysteine protease CatB/L to enter the cell. TMPRSS2 is responsible for the cleavage of the S protein to expose the FP region of the S2 subunit, which is responsible for initiating endosome-mediated host cell entry into it. It shows that TMPRSS2 is a host factor necessary for virus entry. Therefore, the use of drugs that inhibit this protease can achieve the purpose of treatment.

mRNA-1273

The mRNA encoding the full length of SARS-CoV-2, and the pre-spike protein fusion is encapsulated into lipid nanoparticles to form mRNA-1273 vaccine. It can induce a high level of S protein specific antiviral response. It can also consist of inactivated antigens or subunit antigens. The vaccine was quickly approved by the FDA and has entered phase II clinical trials. The company has announced the antibody data of 8 subjects who received different immunization doses. The 25ug dose group achieved an effect similar to the antibody level during the recovery period. The 100ug dose group exceeded the antibody level during the recovery period. In the 25ug and 100ug dose groups, the vaccine was basically safe and tolerable, while the 250ug dose group had 3 levels of systemic symptoms.

Viral vector vaccines can provide long-term high-level expression of antigen proteins, induce CTLs, and ultimately eliminate viral infections.

1, Ad5-nCov

A vaccine of SARS-CoV-2 recombinant spike protein expressed by recombinant, replication-deficient type 5 adenovirus (Ad5) vector. Load the optimized full-length S protein gene together with the plasminogen activation signal peptide gene into the E1 and E3 deleted Ad5 vectors. The vaccine is constructed by the Admax system derived from Microbix Biosystem. In phase I clinical trials, RBD (S1 subunit receptor binding domain) and S protein neutralizing antibody increased by 4 times 14 days after immunization, reaching a peak on 28 days. CD4+T and CD8+T cells reached a peak 14 days after immunization. The existing Ad5 immune resistance partially limits the response of antibodies and T cells. This study will be further conducted in the 18-60 age group, receiving 1/3 of the study dose, and follow-up for 3-6 months after immunization.

DNA vaccine

The introduction of antigen-encoding DNA and adjuvants as vaccines is the most innovative vaccine method. The transfected cells stably express the transgenic protein, similar to live viruses. The antigen will be endocytosed by immature DC, and finally provide antigen to CD4 + T, CD8 + T cells (by MHC differentiation) To induce humoral and cellular immunity. Some specificities of the virus and the new coronavirus mutant are different from general vaccines and other vaccines. Therefore, it is worth noting the gene expression of the vaccine. Otherwise, the effectiveness and efficiency of the vaccine will be questioned.

Live attenuated vaccine

DelNS1-SARS-CoV2-RBD

Basic influenza vaccine, delete NS1 gene. Express SARS-CoV-2 RBD domain. Cultured in CEF and MDCK (canine kidney cells) cells. It is more immunogenic than wild-type influenza virus and can be administered by nasal spray.

The viral genome is susceptible to mutation, antigen transfer and drift can occur, and spread among the population. Mutations can vary depending on the environmental conditions and population density of the geographic area. After screening and comparing 7,500 samples of infected patients, scientists found 198 mutations, indicating the evolutionary mutation of the virus in the human host. These mutations may form different virus subtypes, which means that even after vaccine immunization, viral infections may occur. A certain amount of increment and strengthening is needed here.

Inactivated vaccines, adenovirus vector vaccines, recombinant protein vaccines, nucleic acid vaccines, attenuated influenza virus vector vaccines, etc. According to relevant information, there are dozens of new coronavirus vaccines in the world, and more varieties are being developed and upgraded. Including the United States, Britain, China, Russia, India and other countries, there are more R&D and production units.

AZ vaccine

Modena vaccine

Lianya Vaccine

High-end vaccine

Pfizer vaccine

Pfizer-BioNTech

A large study found that the vaccine developed by Pfizer and German biotechnology company BioNTech is 95% effective in preventing COVID-19.

The vaccine is divided into two doses, which are injected every three weeks.

This vaccine uses a molecule called mRNA as its basis. mRNA is a molecular cousin of DNA, which contains instructions to build specific proteins; in this case, the mRNA in the vaccine encodes the coronavirus spike protein, which is attached to the surface of the virus and used to infect human cells. Once the vaccine enters the human body, it will instruct the body's cells to make this protein, and the immune system will learn to recognize and attack it.

Moderna

The vaccine developed by the American biotechnology company Moderna and the National Institute of Allergy and Infectious Diseases (NIAID) is also based on mRNA and is estimated to be 94.5% effective in preventing COVID-19.

Like Pfizer's vaccine, this vaccine is divided into two doses, but injected every four weeks instead of three weeks. Another difference is that the Moderna vaccine can be stored at minus 20 degrees Celsius instead of deep freezing like Pfizer vaccine. At present, the importance of one of the widely used vaccines is self-evident.

Oxford-AstraZeneca

The vaccine developed by the University of Oxford and the pharmaceutical company AstraZeneca is approximately 70% effective in preventing COVID-19-that is, in clinical trials, adjusting the dose seems to improve this effect.

In the population who received two high-dose vaccines (28 days apart), the effectiveness of the vaccine was about 62%; according to early analysis, the effectiveness of the vaccine in those patients who received the half-dose first and then the full-dose Is 90%. However, in clinical trials, participants taking half doses of the drug are wrong, and some scientists question whether these early results are representative.

Sinopharm Group (Beijing Institute of Biological Products, China)

China National Pharmaceutical Group Sinopharm and Beijing Institute of Biological Products have developed a vaccine from inactivated coronavirus (SARS-CoV-2). The inactivated coronavirus is an improved version that cannot be replicated.

Estimates of the effectiveness of vaccines against COVID-19 vary.

Gamaleya Institute

The Gamaleya Institute of the Russian Ministry of Health has developed a coronavirus vaccine candidate called Sputnik V. This vaccine contains two common cold viruses, adenoviruses, which have been modified so that they will not replicate in the human body; the modified virus also contains a gene encoding the coronavirus spike protein.

New crown drugs

There are many small molecule antiviral drug candidates in the clinical research stage around the world. Including traditional drugs in the past and various drugs yet to be developed, antiviral drugs, immune drugs, Gene drugs, compound drugs, etc.

(A) Molnupiravir

Molnupiravir is a prodrug of the nucleoside analog N4-hydroxycytidine (NHC), jointly developed by Merck and Ridgeback Biotherapeutics.

The positive rate of infectious virus isolation and culture in nasopharyngeal swabs was 0% (0/47), while that of patients in the placebo group was 24% (6/25). However, data from the Phase II/III study indicate that the drug has no benefit in preventing death or shortening the length of stay in hospitalized patients.

Therefore, Merck has decided to fully advance the research of 800mg molnupiravir in the treatment of patients with mild to moderate COVID-19.

(B) AT-527

AT-527 is a small molecule inhibitor of viral RNA polymerase, jointly developed by Roche and Atea. Not only can it be used as an oral therapy to treat hospitalized COVID-19 patients, but it also has the potential as a preventive treatment after exposure.

Including 70 high-risk COVID-19 hospitalized patients data, of which 62 patients' data can be used for virological analysis and evaluation. The results of interim virological analysis show that AT-527 can quickly reduce viral load. On day 2, compared with placebo, patients treated with AT-527 had a greater decline in viral load than the baseline level, and the continuous difference in viral load decline was maintained until day 8.

In addition, compared with the control group, the potent antiviral activity of AT-527 was also observed in patients with a baseline median viral load higher than 5.26 log10. When testing by RT-qPCR to assess whether the virus is cleared,

The safety aspect is consistent with previous studies. AT-527 showed good safety and tolerability, and no new safety problems or risks were found. Of course, there is still a considerable distance between experiment and clinical application, and a large amount of experimental data can prove it.

Prokalamide is an AR (androgen receptor) antagonist. Activated androgen receptor AR can induce the expression of transmembrane serine protease (TMPRSS2). TMPRSS2 has a shearing effect on the new coronavirus S protein and ACE2, which can promote the binding of viral spike protein (S protein) to ACE, thereby promoting The virus enters the host cell. Therefore, inhibiting the androgen receptor may inhibit the viral infection process, and AR antagonists are expected to become anti-coronavirus drugs.

Positive results were obtained in a randomized, double-blind, placebo-controlled phase III clinical trial. The data shows that Prokalutamide reduces the risk of death in severely ill patients with new coronary disease by 92%, reduces the risk of new ventilator use by 92%, and shortens the length of hospital stay by 9 days. This shows that procrulamide has a certain therapeutic effect for patients with severe new coronary disease, which can significantly reduce the mortality of patients, and at the same time greatly reduce the new mechanical ventilation and shorten the patient's hospital stay.

With the continuous development of COVID-19 on a global scale, in addition to vaccines and prevention and control measures, we need a multi-pronged plan to control this disease. Oral antiviral therapy undoubtedly provides a convenient treatment option.

In addition, there are other drugs under development and experimentation. In dealing with the plague virus, in addition to the strict control of protective measures, it is very important that various efficient and safe vaccines and various drugs (including medical instruments, etc.) are the ultimate nemesis and killer of the virus.

(A) "Antiviral biological missiles" are mainly drugs for new coronaviruses and mutant viruses, which act on respiratory and lung diseases. The drugs use redundant designs to inhibit new coronaviruses and variant viruses.

(B) "New Coronavirus Epidemic Prevention Tablets" mainly use natural purified elements and chemical structure modifications.

(D) "New Coronavirus Long-acting Oral Tablets" Chemical modification of antiviral drugs, multiple targets, etc.

(E) "New Coronavirus Inhibitors" (injections) are mainly made of chemical drug structure modification and other preparations.

The development of these drugs mainly includes: drug target screening, structure-activity relationship, chemical modification, natural purification, etc., which require a lot of work and experimentation.

Humans need to vigorously develop drugs to deal with various viruses. These drugs are very important for the prevention and treatment of viruses and respiratory infectious diseases, influenza, pneumonia, etc.

The history of human development The history of human evolution, like all living species, will always be accompanied by the survival and development of microorganisms. It is not surprising that viruses and infectious diseases are frequent and prone to occur. The key is to prevent and control them before they happen.

This strain was first discovered in India in October 2020 and was initially called a "double mutant" virus by the media. According to the announcement by the Ministry of Health of India at the end of March this year, the "India New Coronavirus Genomics Alliance" composed of 10 laboratories found in samples collected in Maharashtra that this new mutant strain carries E484Q and L452R mutations. , May lead to immune escape and increased infectivity. This mutant strain was named B.1.617 by the WHO and was named with the Greek letter δ (delta) on May 31.

Shahid Jamil, the dean of the Trivedi School of Biological Sciences at Ashoka University in India and a virologist, said in an interview with the Shillong Times of India that this mutant strain called "double mutation" is not accurate enough. B. 1.617 contains a total of 15 mutations, of which 6 occur on the spike protein, of which 3 are more critical: L452R and E484Q mutations occur on the spike protein and the human cell "Angiotensin Converting Enzyme 2 (ACE2)" receptor In the bound region, L452R improves the ability of the virus to invade cells, and E484Q helps to enhance the immune escape of the virus; the third mutation P681R can also make the virus enter the cell more effectively. (Encyclopedia website)

There are currently dozens of antiviral COVID-19 therapies under development. The large drugmakers Merck and Pfizer are the closest to the end, as expected, a pair of oral antiviral COVID-19 therapies are undergoing advanced human clinical trials.

Merck's drug candidate is called monupiravir. It was originally developed as an influenza antiviral drug several years ago. However, preclinical studies have shown that it has a good effect on SARS and MERS coronavirus.

Monupiravir is currently undergoing in-depth large-scale Phase 3 human trials. So far, the data is so promising that the US government recently pre-ordered 1.7 million courses of drugs at a cost of $1.2 billion. If everything goes according to plan, the company hopes that the drug will be authorized by the FDA for emergency use and be on the market before the end of 2021.

Pfizer's large COVID-19 antiviral drug candidate is more unique. Currently known as PF-07321332, this drug is the first oral antiviral drug to enter human clinical trials, specifically targeting SARS-CoV-2.

Variant of Concern WHO Label First Detected in World First Detected in Washington State

B.1.1.7 Alpha United Kingdom, September 2020 January 2021

B.1.351 Beta South Africa, December 2020 February 2021

P.1 Gamma Brazil, April 2020 March 2021

B.1.617.2 Delta India, October 2020 April 2021

Although this particular molecule was developed in 2020 after the emergence of the new coronavirus, a somewhat related drug called PF-00835231 has been in operation for several years, targeting the original SARS virus. However, the new drug candidate PF-07321332 is designed as a simple pill that can be taken under non-hospital conditions in the initial stages of SARS-CoV-2 infection.

"The protease inhibitor binds to a viral enzyme and prevents the virus from replicating in the cell," Pfizer said when explaining the mechanism of its new antiviral drug. "Protease inhibitors have been effective in the treatment of other viral pathogens, such as HIV and hepatitis C virus, whether used alone or in combination with other antiviral drugs. Currently marketed therapeutic drugs for viral proteases are generally not toxic Therefore, such molecules may provide well-tolerated treatments against COVID-19."

Various studies on other types of antiviral drugs are also gaining momentum. For example, the new coronavirus pneumonia "antiviral biological missile", "new coronavirus prevention tablets", "composite antiviral oral liquid", "new coronavirus long-acting oral tablets", "new coronavirus inhibitors" (injections), etc., are worthy of attention. Like all kinds of vaccines, they will play a major role in preventing and fighting epidemics.

In addition, Japanese pharmaceutical company Shionoyoshi Pharmaceutical is currently conducting a phase 1 trial of a protease inhibitor similar to SARS-CoV-2. This is called S-217622, which is another oral antiviral drug, and hopes to provide people with an easy-to-take pill in the early stages of COVID-19. At present, the research and development of vaccines and various new crown drugs is very active and urgent. Time does not wait. With the passage of time, various new crown drugs will appear on the stage one after another, bringing the gospel to the complete victory of mankind.

The COVID-19 pandemic is far from over. The Delta mutant strain has quickly become the most prominent SARS-CoV-2 strain in the world. Although our vaccine is still maintained, it is clear that we need more tools to combat this new type of coronavirus. Delta will certainly not be the last new SARS-CoV-2 variant we encountered. Therefore, it is necessary for all mankind to persevere and fight the epidemic together.

Overcome illness and meet new challenges. The new crown epidemic and various mutated viruses are very important global epidemic prevention and anti-epidemic top priorities, especially for the current period of time. Vaccine injections, research and development of new drugs, strict prevention and control, wear masks, reduce gatherings, strictly control large gatherings, prevent the spread of various viruses Masks, disinfection and sterilization, lockdown of the city, vaccinations, accounting and testing are very important, but this does not mean that humans can completely overcome the virus. In fact, many spreading and new latently transmitted infections are still unsuccessful. There are detections, such as invisible patients, asymptomatic patients, migratory latent patients, new-onset patients, etc. The struggle between humans and the virus is still very difficult and complicated, and long-term efforts and exploration are still needed, especially for medical research on the new coronavirus. The origin of the disease, the course of the disease, the virus invaded The deep-level path and the reasons for the evolution and mutation of the new coronavirus and the particularity of prevention and treatment, etc.). Therefore, human beings should be highly vigilant and must not be taken lightly. The fierce battle between humans and various viruses must not be slackened. Greater efforts are needed to successfully overcome this pandemic, fully restore the normal life of the whole society, restore the normal production and work order, restore the normal operation of society, economy and culture, and give up food due to choking. Or eager for success, will pay a high price.

———————————————————————————————————————————————— ————

References References are made to web resources, and related images are from web resources and related websites.

Who official website UN .org www.gavi.org/ispe.org

Wikipedia, "The Lancet", "English Journal of Medicine", "Nature", "Science", "Journal of the American Medical Association", etc.

Learning from history: do not flatten the curve of antiviral research!

T Bobrowski, CC Melo-Filho, D Korn, VM Alves...-Drug discovery today, 2020-

go.drugbank.com/

A critical overview of computational approaches employed for COVID-19 drug discovery

EN Muratov, R Amaro, CH Andrade, N Brown...-Chemical Society..., 2021-pubs.rsc.org

Global Research Performance on COVID 19 in Dimensions Database

J Balasubramani, M Anbalagan-2021-researchgate.net

Adoption of a contact tracing app for containing COVID-19: a health belief model approach

M Walrave, C Waeterloos...- JMIR public health and..., 2020-publichealth.jmir.org

Prophylactic Treatment Protocol Against the Severity of COVID-19 Using Melatonin

N Charaa, M Chahed, H Ghedira...-Available at SSRN..., 2020-papers.ssrn.com

　Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet

　Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany, New England Journal of Medicine

The actions of respiratory therapists facing COVID-19

Zhu Jiacheng-Respiratory Therapy, 2021-pesquisa.bvsalud.org

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, The Lancet

　Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China, JAMA, February 7

Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China, JAMA

Delta variant triggers new phase in the pandemic | Science

science.sciencemag.org›

COVID vaccines slash viral spread – but Delta is an unknown

www.nature.com ›articles

Novel coronavirus pneumonia during ophthalmic surgery management strategy and recommendations

YH HUANG, SS LI, X YAO, YR YANG, DH QIN…-jnewmed.com

Delta variant: What is happening with transmission, hospital ...

www.bmj.com

Risk of long QT syndrome in novel coronavirus COVID-19

VN Oslopov, JV Oslopova, EV Hazova…-Kazan medical…, 2020-kazanmedjournal.ru

Study compares mRNA and adenovirus-based SARS-CoV-2 vaccines ...

www.news-medical.net

First molecular-based detection of SARS-CoV-2 virus in the field-collected houseflies

A Soltani, M Jamalidoust, A Hosseinpour, M Vahedi...-Scientific Reports, 2021-nature.com

Covid 19 DELTA Variant Archives-Online essay writing service

sourceessay.com ›tag› covid-19-delta-variant

SARS-CoV-2 Delta variant Likely to become dominant in the ...

www.news-medical.net

Compilation postscript

Once Fang Ruida's research literature on the new crown virus and mutant virus was published, it has been enthusiastically praised by readers and netizens in dozens of countries around the world, and has proposed some amendments and suggestions. Hope to publish a multilingual version of the book as an emergency To meet the needs of many readers around the world, in the face of the new crown epidemic and the prevention and treatment of various mutant viruses, including the general public, college and middle school students, medical workers, medical colleagues and so on. According to the English original manuscript, it will be re-compiled and published. Inconsistencies will be revised separately. Thank you very much.

Jacques Lucy, Geneva, Switzerland, August 2021

*********************************************************************

Leader mondial, scientifique, scientifique médical, virologue, pharmacien et professeur Fangruida (F.D Smith) sur l'épidémie mondiale et l'ennemi juré et la prévention des nouveaux coronavirus et virus mutants (Jacques Lucy 2021v1.5)

_-----------------------------------------

L'ennemi juré et le tueur du nouveau coronavirus et des virus mutés - Développement conjoint de vaccins et de médicaments (Fangruida) Juillet 2021

* La particularité des nouveaux coronavirus et des virus mutants * Le large spectre, la haute efficacité, la redondance et la sécurité de la conception et du développement du nouveau vaccin contre le coronavirus, Redondance et sécurité

* Nouvelle modification de la structure chimique des médicaments contre les coronavirus * Conception et dépistage des médicaments assistés par ordinateur. *"Missile biologique antiviral", "Nouveaux comprimés anti-épidémiques contre le coronavirus", "Liquide oral antiviral composite", "Nouveaux comprimés oraux à action prolongée contre le coronavirus", "Nouveaux inhibiteurs de coronavirus" (injection)

——————————————————————————

(leader mondial, scientifique, scientifique médical, biologiste, virologue, pharmacien, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" est un important document de recherche scientifique. Il a maintenant été révisé et réédité par l'auteur original à plusieurs reprises. La compilation est publiée et publiée selon le manuscrit original pour répondre aux besoins des lecteurs et des internautes du monde entier. En même temps, elle est également très bénéfique pour le grand nombre de chercheurs en médicaments cliniques médicaux et de divers experts et universitaires. Nous espérons qu'il sera corrigé dans la réimpression.------Compilé par Jacques Lucy à Genève, août 2021

-------------------------------------------------- ---------------------

Selon les statistiques en temps réel de Worldometer, vers 6h30 le 23 juillet, il y avait un total de 193 323 815 cas confirmés de nouvelle pneumonie coronarienne dans le monde, et un total de 4 150 213 décès. Il y a eu 570 902 nouveaux cas confirmés et 8 766 nouveaux décès dans le monde en une seule journée. Les données montrent que les États-Unis, le Brésil, le Royaume-Uni, l'Inde et l'Indonésie sont les cinq pays avec le plus grand nombre de nouveaux cas confirmés, et l'Indonésie, le Brésil, la Russie, l'Afrique du Sud et l'Inde sont les cinq pays avec le plus grand nombre de nouveaux décès.

Les nouvelles souches de coronavirus et de mutants delta ont été particulièrement graves ces derniers temps. De nombreux pays et lieux ont repris vie et le nombre de cas n'a pas diminué, mais a augmenté.

, Il est digne de vigilance. Bien que de nombreux pays aient renforcé la prévention et le contrôle des vaccins et d'autres mesures de prévention et de contrôle, il existe encore de nombreuses lacunes et carences dans la suppression et la prévention du virus. Le nouveau coronavirus et diverses souches mutantes présentent un certain degré d'antagonisme par rapport aux médicaments traditionnels et à la plupart des vaccins. Bien que la plupart des vaccins aient de grandes propriétés anti-épidémiques et aient des effets et une protection importants et irremplaçables pour la prévention et le traitement, il est impossible d'empêcher complètement la propagation et l'infection des virus. La propagation de la nouvelle pneumonie à virus couronne a été retardée de près de deux ans. Il y a des centaines de millions de personnes infectées dans le monde, des millions de décès, et le temps est long, la propagation est généralisée et des milliards de personnes dans le monde sont parmi Les dommages causés par le virus sont assez terribles, c'est bien connu. Plus urgent

Ce qui est plus grave, c'est que le virus et les souches mutantes n'ont pas complètement reculé, surtout que de nombreuses personnes sont encore infectées et infectées après avoir été injectées avec divers vaccins.L'efficacité du vaccin et la résistance du virus mutant sont dignes des scientifiques médicaux, virologues , les pharmacologues Les zoologistes et autres réfléchissent et analysent sérieusement. La situation épidémique actuelle dans les pays européens et américains, la Chine, le Brésil, l'Inde, les États-Unis, la Russie et d'autres pays s'est considérablement améliorée par rapport à l'année dernière.Cependant, les chiffres pertinents montrent que la situation épidémique mondiale ne s'est pas complètement améliorée, et certains pays et régions sont encore très graves. En particulier, après une utilisation intensive de divers vaccins, des cas surviennent encore, et dans certains endroits ils sont encore très graves, ce qui mérite une grande vigilance. Les mesures de prévention et de contrôle sont très importantes.De plus, les vaccins et divers médicaments antiépidémiques sont les premiers choix nécessaires, et les autres méthodes sont irremplaçables. Il est particulièrement important de développer et de développer des médicaments complets, des médicaments antiviraux, des médicaments immunitaires et des médicaments génétiques. Les expériences de recherche sur les nouveaux coronavirus et virus mutants nécessitent une analyse plus rigoureuse et approfondie des données, des tissus pathogènes pathologiques, des gènes cellulaires, de la chimie moléculaire, de la chimie quantique, etc., ainsi que de la chimie moléculaire des vaccins, de la physique quantique, de la biologie quantique, de l'histologie cytologique, la chimie médicinale et les médicaments Et les symptômes, l'efficacité, la sécurité, l'efficacité à long terme, etc. du vaccin, bien sûr, y compris des dizaines de milliers de cas cliniques et de décès et d'autres informations et preuves de première main. La tâche de l'ARN (acide ribonucléique) dans le corps humain est d'utiliser les informations de notre matériel génétique ADN pour produire des protéines. Il accomplit cette tâche dans le ribosome, la zone productrice de protéines de la cellule. Le ribosome est le lieu où se produit la biosynthèse des protéines.

La médecine en profite : dans la vaccination, l'ARNm produit artificiellement fournit aux ribosomes des instructions pour construire des antigènes pathogènes contre lesquels lutter, par exemple, la protéine de pointe du coronavirus.

Les vaccins vivants traditionnels ou les vaccins inactivés contiennent des antigènes qui provoquent la réaction du système immunitaire. Le vaccin à ARNm est produit dans la cellule

(1) La spécificité des nouveaux coronavirus et virus mutants, etc., virologie et chimie quantique des virus mutants, physique quantique, microbiologie quantique

(2) Nouvelle conception de vaccin couronne, biologie moléculaire et structure chimique, etc.

(3) La généralité et la particularité du développement de nouveaux médicaments contre le coronavirus

(4) Diverses conceptions de médicaments pour la pneumonie à nouveau coronavirus, la chimie médicinale, la pharmacologie, etc., les cellules, les protéines, l'ADN, la chimie des enzymes, la chimie quantique pharmaceutique, la physique quantique pharmaceutique, la biochimie humaine, la biophysique humaine, etc.

(5) Les caractéristiques d'évolution et de mutation du nouveau coronavirus et de divers virus mutants, la nature à long terme, la répétabilité, la résistance aux médicaments et la résistance épidémique du virus, etc.

(6) Pneumonie à nouveau coronavirus et transmission infectieuse de divers nouveaux coronavirus et leurs particularités

(7) La transmission invisible de la pneumonie à nouveau coronavirus et de divers virus mutants chez l'homme ou l'animal, et la symbiose mutuelle de l'infection croisée de diverses bactéries et virus sont également l'une des causes très graves de dommages graves aux nouveaux coronavirus et virus mutants. La virologie, la pathologie, l'étiologie, le séquençage des gènes, la cartographie des gènes et un grand nombre d'études analytiques ont montré qu'il existe de nombreux cas en Chine, aux États-Unis, en Inde, en Russie, au Brésil et dans d'autres pays.

(8) Pour la prévention et le traitement symptomatiques du nouveau coronavirus, la combinaison de divers vaccins et de di

Day 126- Strain by Amanda

1 12

Casey's lungs are jerks.

She had lung surgery on her left lung in January. At that time, we knew she had cancer in her right lung again. She went in for her scans before her 2nd right lung surgery, and they found more cancer in her left lung. Basically, her cancer is not giving a single fuck about chemo or surgery.

So I don't know what we're doing yet. The nurse practitioner is running an idea past the surgeon for a new type of surgery using heat to kill the nodules. So that might happen.

This isn't funny anymore, guys.

Space Telescope Marks Key Milestone by NASA's James Webb Space Telescope

Goddard Space Flight Center Director Rob Strain (left) stands with Marshall Space Flight Center Director Robert Lightfoot. Between them, the James Webb Space Telescope mirror array is visible as it stands in the high bay clean room.

The first six of 18 segments that will form NASA's James Webb Space Telescope’s primary mirror for space observations will begin final round-the-clock cryogenic testing this week. These tests will confirm the mirrors will respond as expected to the extreme temperatures of space prior to integration into the telescope's permanent housing structure.

Credit: NASA/MSFC/David Higginbotham

NASA Image Use Policy

Like us on Facebook

Subscribe to our YouTube channel

Julie Strain by Corina Chirla

28131 by Corina Chirla

A Window into Twitter by Wendy Harman

16" x 20" on stretched canvas. Sealed.

So I took a 5 minute snapshot of the Twitter search mechanism for the word WINDOW and these are the tweets that came up:

Window washer came today at work. Dude with suction cups, squeegee, and cables dangling from a 30 story bldg. Couldn’t pay me enough money.

Woke up to a bird fling into my window this morning. :/

Haha! I just convinced my little brother that I can transport places cause I climbed out of my window and came back into the house. 

Just looked out the window and saw a kid face plant from a bike what a dumb kid he needs to learn how to use his breaks.

I apologize for making out with that mannequin. I thought it would lift my sagging window dressing career like in that documentary I saw.

When choosing aisle or window seat on plane you need only ask yourself one question: Do I go to the bathroom more or less often than the average person?

Being entertained by a child I cannot see. All I see is a tiny little arm stuck out the window of an enormous RV.

What ever happened to common sense? Did it really fly out the window?

So my kitchen window looks out on the road and across our street was a rooster peckin around making noise. Weird.

Creepy neighbor alert! I’m washing dishes and see the old man neighbor walk by, turn around, and strain his neck to look in my window.

The tramp who lives across the street is playing the harmonica. My bedroom window is wide open, I can hear it clear as a bell.

There is a bright red dragonfly sitting on a bush just outside my office window. It is awesome with a wingspan 5 inches across. Beautiful.

Just saw a tow truck with this across the back window: “We don’t want an arm and a leg, just your tows!” LOL

Signs of Strain by einaros

Couldn't decide between this one and the other similar shot (http://www.flickr.com/photos/einaros/3715618369/), so I went rogue and upped both.

Strain by Paul Oellermann

5 5

Approaching clouds signal the end of sunshine for Tauranga.

straining the syrup by deb

Fairytale of New York on smittenkitchen.com

Drucilla Strain 002 by Anjel Candy

Drucilla Anna Strain (1913-1994) Actress and Ziegfeld Girl born in New York City to parents Robert Strain (1893-1950) and Anna Fallon (1894-1981). She married Charles Eugene Teagarden (1913-1984) in 1931 and had a daughter Druanne Teagarden (1939-1981). She later married Dick Stone and died in Long Beach, Nassau, New York 1994.

photographer - Alfred Cheney Johnston

Image Enhancement - Vizmage Studio

Strain & Shields by Martin Mackillop

GF60 RTU

Strain your broth by Lauren

5 1

www.veganyumyum.com

The Acacia Strain by Alec Hartman

New England Metal and Hardcore Festival 7 (Day 2)

April 23rd, 2005

Worcester, MA - The Palladium

Chimaira, Bleeding Through, God Forbid, Blood Has Been Shed, Bury Your Dead, It Dies Today, Remembering Never, The Acacia Strain, Glass Casket, The Killing

-----

For video footage from some of the shows I've been to check out my Youtube account at: www.youtube.com/user/lanvids

For some of my other (non-concert) photography check out my main Flickr page at: www.flickr.com/photos/lanimilbus

For a full collection of my photography check out my website at: www.lanimilbus.com

Taking the strain by Chris Shepheard

Emsworth

Statue strain by Stephen Dowling

Lomo Lubitel 166U

Fuji Provia 100F

Unknown strain. by themadpothead

7 3

Funky!!!

Perhaps some kind of dream bud?... quick someone pinch me!

The Acacia strain by Will Putney

Tess by Colin Strain

8 3

Taking the Strain by Kenny Maths

1 48

Two performers from Cirque du Soleil's show 'Quidam' performed at Glasgow's SECC a couple of months ago.

I owe a debt of gratitute to Alex Hewitt from The Scotsman for arranging my photo pass for this show...and also to Marie-Josée Gagnon (the Publicist for Cirque du Soleil) for looking after the photographers at the SECC.

This was taken at ISO 3200 with a shutter speed of 1/25 sec...using the long end of a 70-300mm zoom (hand held).

You can more shots from this show in my Cirque du Soleil set.

Oh...and if you like this sort of thing, you may care to check out my rather popular Kataklo set.

1 2 ••• 9 10 11 12 13 14 15 ••• 79 80

Tags straining

View allAll Photos Tagged straining