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I had a 7:00am sound check this morning. That whole concept is so wrong. Musicians aren't wired for mornings to start with, so asking us to do something at 7:00am is silly.
Asking us to do make music at 7:00am is sillier still.
7:00am Sound check? It's an oxymoron, like Airborne Infantry, and Military Intelligence.
So, this is an MRI printout I had done this morning after sound check, teaching, major's market, dot dot dot. This is my brain, not wired for mornings.
Neurona AP de sanguijuela (Hirudo medicinalis) regenerando en medio de cultivo con Concanavalina A... Ok después del choro técnico, esto era lo que hacia en el Instituto de FisiologÃa Celular, antes de cambiar los microscópios por los binoculares, o sea, antes de ser biólogo de campo era una rata de laboratorio que es lo mismo que un Biólogo molecular o BiofÃsico =) ja ja.. Sin ofender, que tengo muchos amigos biólogos moleculares
Neurone du cervelet (structure triangulaire en rouge au centre ; son noyau, circulaire apparaît en violet) projetant ses prolongements vers le site de genèse des mouvements involontaires dans la maladie de Parkinson. La stimulation intermittente des terminaisons nerveuses (en vert) dans un modèle de Parkinson chez la souris permet de prévenir l’apparition de ces mouvements involontaires.
©Daniela Popa/Inserm.licence CC-BY-NC 4.0 international
En savoir plus : Dans une étude parue en juin 2022, des chercheurs et chercheuses sous la supervision de Clément Léna et Daniela Popa, directeur et directrice de recherche Inserm, montrent que des stimulations depuis la surface du cerveau, au niveau du cervelet, suffisent à supprimer les mouvements involontaires (ou dyskinésies) liés à la maladie de Parkinson.
Ils ont entrepris de tester une voie thérapeutique alternative pour traiter ces mouvements anormaux dans un modèle animal de la maladie de Parkinson. Ils ont administré des stimulations spécifiques des cellules de Purkinje du cervelet depuis la surface du cerveau, quelques dizaines de secondes par jour.
Celles-ci se sont révélées capables de supprimer les mouvements anormaux. Mieux encore, ce traitement a normalisé l’activité des circuits moteurs, y compris au niveau du site de genèse présumée de ces dyskinésies, au sein des ganglions de la base.
Les résultats ont montré que ce traitement met en jeu des mécanismes de plasticité, qui perdurent pendant plusieurs jours voire semaines. Ces stimulations de la surface du cervelet, administrables de façon non invasive, fournissent une voie d’accès nouvelle pour le traitement d’affections profondes dans le cerveau. Les mécanismes cellulaires des plasticités restent à être identifiés.
L’équipe cherche maintenant à mieux comprendre et à optimiser ces pratiques pour reproduire leurs effets bénéfiques chez les patients
Source : Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network, 09/06/2022, Nature Communications
Neurons transmit electrical signals to muscles through a thin connection called an axon. The axon is covered by a sort of insulation called the myelin sheath, which is like the plastic coating on your charger cord. In ALS, this coating is eaten away, and the signal is lost before it reaches the muscle. When the muscle stops recieving signals, it begins wasting away. Using a copper-rich compound, OSU professor Joe Beckman and his team were able to restore the myelin sheath in mice damaged by ALS. The compound is in clinical trials to evaluate its safety, and patients and their families are cautiously optimistic that this might help extend the lives of people with Lou Gehrig’s disease. #OSU150
Inverted image of GFP expressing neurons in the larval ventral cord of a th-Gal4, UAS-GFP strain. For more info go here:
genetics.biozentrum.uni-wuerzburg.de/home/hiromut/paper/T...
or
Blue linen blouse screen printed with neurons of the hippocampus as illustrated by Santiago Ramon y Cajal.
Campo oscuro. Filtro DiI. Tinción con cristales.
Prácticas NeurobiologÃa. Diciembre 2011. Universidad de Málaga
Artist Gemma Wood MA created the concept of Being Now Here for the development of immersive environments and impactful art installations for festivals and exhibitions. Her work is uplifting, thought-provoking and offers the public a truly memorable experience. She has a background in social engagement and has collaborated with a multitude of craftsmen, engineers and communities to deliver unique creative workshops.
Gemma contacted Glow Inflatables Ltd with a vision; to create a pair of giant electrical neurons for display at the Deer Shed contemporary arts festival at Baldersby Park, North Yorkshire. She worked closely with Jenny, our creative director, to explore the concept of the transmission of thoughts and create a design that could also be used as part of a large neural network through connectivity.
The most exciting element of the already beautiful visual display was the LED light that chased through the piece from one to another. Gemma coupled these elements with sound from the broken orchestra so when walking in and around the piece it felt like you were walking through someone’s thoughts. Visitors to the Deer Shed Festival could enter the imaginary mind and experience the messages as they flashed from neuron to neuron.
The artist said that the spectators really understood what the concept was and enjoyed it. ‘’The installation worked brilliantly; people were interested day and night but especially as the lights became visible.’’
www.glowinflatables.com/inflatable-blog/inflatable-neuron...