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Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant death. The disease is caused due to the depletion of the ubiquitously expressed survival motor neuron (SMN) protein. However, the scientific community has still yet to understand how diminished levels of SMN specifically affect motor neurons, leading to paralysis and ultimately death.
Animal models are often used to explore therapeutic avenues for treatment of such diseases like SMA. Therefore, I was delighted to be given the opportunity to work with the three-time Nobel Prize ‘winner’ C.elegans. This amazing roundworm has proven itself to be highly valuable in making some of the most iconic scientific breakthroughs throughout history.
I decided to share an image of the C.elegans SMA model in comparison to a healthy animal, which are used by the University’s C.elegans research team, to investigate the molecular and cellular pathways, underpinning this devastating disorder.
My proposed research looks at using the C.elegans SMA model to ‘Investigate the role of oxidative stress’, with the ultimate goal to develop effective SMA therapies.
Fathama Mutaleb
Clinical, Pharmaceutical and Biological Science (CPBS)
School of Life and Medical Sciences
Hotulainen et al. investigate actin polymerization within dendritic spines, the small protrusions that form synapses with excitatory neurons. Expressing an inactive form of the small GTPase Rif (bottom), or depleting its effector, the formin mDia2 (middle), produces spines with shorter necks and larger heads. (JCB 185(2) TOC2)
This image is available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
Reference: Hotulainen (2009) J. Cell Biol. 323-339.
Published on: April 20, 2009.
Doi: 10.1083/jcb.200809046.
Read the full article at:
Excitatory pyramidal neurons from mouse visual cortex.
Render by Amy Sterling from
reconstructions by Seung Lab, Princeton Neuroscience Institute using images acquired by The Allen Institute. Funded by IARPA MICrONS. Rendered in Cinema 4D using Otoy Octane GPU renderer.
Something a bit different. I haven't had any time lately for photography. But I've been spending long days at the confocal microscope. This is one of my favorite images.
Linen blouse screen printed with regenerating neurons as illustrated by Santiago Ramon y Cajal. Textile print and blouse by Melina Bloomfield.
Synapses arriving at an excitatory neuron (blue) of mouse visual cortex.
Render by Amy Sterling from
reconstructions by Seung Lab, Princeton Neuroscience Institute using images acquired by The Allen Institute. Funded by IARPA MICrONS. Rendered in Cinema 4D using Otoy Octane GPU renderer.
This in vivo 2-photon image was created using viral vectors from the viral gene transfer core, a facility established in 2008 by the Picower Institute and the McGovern Institute to make viral vectors accessible to the MIT neuroscience community.
Image courtesy of Sam Clark, McGovern Institute for Brain Research at MIT
This neuron, created in the Su-Chun Zhang lab at the University of Wisconsin-Madison, makes dopamine, a neurotransmitter involved in normal movement. The cell originated in an induced pluripotent stem cell, which derive from adult tissues. Similar neurons survived and integrated normally after transplant into monkey brains -- as a proof of principle that personalized medicine may one day treat Parkinson's disease.
Photo credit: 2010 image, by Yan Liu and Su-Chun Zhang, Waisman Center, University of Wisconsin-Madison
Voy a guardarte en una neurona sin conexión para que no te deslices en cualquier dirección. En la primer gota de la ducha, en la tercera cuchara de azúcar y en el pliegue de mi pijama. En la luz roja del semáforo y en el olor de los pinos del bosque y del otoño de este año. En la lágrima que vino después de la risa. En la estrella de mi ventana. En el almohadón, en la manta y en los calcetines. En las sendas peatonales, en el billete del metro, en la moneda olvidada del monedero. En el jabón de vainilla. En el rosa de la lapicera, en las caricias de Clint y en la sal de las palomitas de maíz. Voy a guardarte, solo por quererte como te quiero y quererte solo para mí, en un lugar de ámbar que es solo mío, de sueños bonitos sin máscaras y sin concilios. En un lugar, un lugar que de tan mío no te vas a poder escapar pero tampoco te querras ir (...) Voy a guardarte en una caja china, en ninguna duda. LSS
Synapses arriving at an excitatory neuron (yellow) of mouse visual cortex.
Render by Amy Sterling from
reconstructions by Seung Lab, Princeton Neuroscience Institute using images acquired by The Allen Institute. Funded by IARPA MICrONS. Rendered in Cinema 4D using Otoy Octane GPU renderer.
Inside every adolescent brain, 86 billion neurons connect and collide to produce the most frustrating, chaotic and exhilarating changes that will ever happen to us.
#LYTMindYourHead
Lyceum Youth Theatre and Traverse Young Writers present Mind Your Head, a double bill of performances which examines the hot topic of mental wellbeing for young people today.
Each evening show will feature Brainstorm, exploring the complexities of the adolescent brain in a unique performance conceived by a playwright, a neuroscientist and partially devised by the LYT cast themselves.
Brainstorm will be paired with a selection of short scenes by the Traverse Young Writers who have responded to themes of the science and biology behind emotions, and nature verses nurture
What does happiness mean? Is it material or emotional? Controlled by circumstances or temperament?
Find out more at: lyceum.org.uk/whats-on/production/1061
Photography by Ryan Buchanan