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Sur cette image de neurone d’hippocampe de rat, obtenue en microscopie confocale après 21 jours en culture (in vitro), on observe les détails des compartiments du neurone permettant la transmission d'une information au sein du cerveau.
En magenta, on peut distinguer les dendrites (ramifications) d'un neurone et en jaune/orange la partie proximale de l'axone, une extension unique du neurone qui propage l'information depuis le corps, jusqu'aux terminaisons nerveuses (ou synapses). Sa partie proximale, appelée "Axon Initial Segment (AIS)", présente une concentration de la protéine anikyrine G (codée par le gène ANK3), qui participe à la transmission de l’information neuronale. Ici, le dysfonctionnement de cette protéine dans le neurone a eu pour conséquence la formation anormale de 5 axones au lieu d’un et, par conséquent, de 5 AIS.
Cette image est extraite d'un travail mené par une équipe de chercheurs de l'Inserm qui cherche à mieux comprendre les troubles du développement neurologique (TND). Ces troubles entrainent des pathologies telles que les troubles du spectre autistique (TSA) ou l'épilepsie. Les résultats de leurs recherches rapportent que lorsque la protéine Prickle 2 est défectueuse, différents compartiments du neurone sont affectés ce qui entraîne une mauvaise transmission d'information. Ces défauts peuvent avoir des conséquences sur l’efficacité des approches thérapeutiques actuellement proposées pour les TND. Les avoir repérés et avoir identifié cette protéine défectueuse est un pas de plus vers la mise au point de thérapies plus efficaces.
© Ana Dorrego-Rivas et Mireille Montcouquiol /Inserm.licence CC-BY-NC 4.0 international
Source : The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling, ScienceAdvances, 9 septembre 2022
Breaking The Spelll | Psychological Artistry - September 2013
Hi,
On the Sleight of Mind Set day we break the spell by not only teaching you the tricks and illusions but go behind the curtain and revealing the psychology of the methods.
This is where the real power lies, by giving you the recipe for turning these tricks into effects that work for you. My goal of the day is to share with you many of the tools, techniques and ideas that have entertained and mystified people over the past 100 years.
These ideas, tools and techniques are not just restricted to being used to deliver Mind Magic, they can be applied across other areas too. They allow you to:-IN THIS WEEK'S NEWSLETTER:
Raise Your Novelty Level
It's All Smoke and Mirror Neurons
Who Still Believes in Magic?
Enter the Mind Magician
Information Alone Is Not Motivation
Psychological Artistry
What Do You Get On The Workshops?
What Do People Say About The Workshops?
Booking Your Place
Show your unique perspective
Make events unique and special
Channel your drive
Exude your sense of fun
Inspire others with your ideas
Evidence your passion and empathy
Standout and apart from the crowd
Add value to others
Create curiosity and a buzz
Plant seeds of future conversations
Take up an authoritative stance
Provide a memorable experience
Forget neutrality; we have to make an impact. Your message has no value unless it makes an impact. We have to show agility in how we think, in cognitive fitness terms, we have to show mental acuity. By making an impact and showing mental acuity you make an emotional connection you are stirring the mirror neurons in others minds.
The Sleight of Mind Set Workshops are being held around the country in Doncaster - 13th September 2013, Bath - 21st September 2013, London - 1st October 2013, Glasgow - 8th October 2013 and Birmingham - 15th October 2013. For more information, please see www.mindsways.com/SMS/
RAISE YOUR NOVELTY LEVEL
Regardless of your current situation you are aware that you have a lot more potential. A way forward that comes from the neuroscience of leadership is to introduce something novel into your mix, this is precisely what the SMS day is all about. The overall idea is that by its very nature, learning Mind Magic is novel to many people, as are the tools and techniques used in it. It is about creating a new perspective, seeing your world from a different angle and raising your level through embracing novelty.
Engaging with and using Mind Magic works on many levels for you. It is novel and entertaining, it attracts and holds people's attention. You will witness the attention that floating a borrowed note in front of people gives you. It is also about firing and stirring the mirror neurons whilst fufilling a need for:
Control
Status - Leadership
Showing Special Powers
Mystery and the unexplained
Emotional Connection with others
To see some of this in action please look at these videos at www.mindsways.com/SMS/
IT'S ALL SMOKE AND MIRROR NEURONS
Enter the magician: A saying that has long been associated with magicians is that it is all done with smoke and mirrors. Well, there is obviously a bit of truth in that, but Mind Magic is done through Mirror Neurons. In 1992 an Italian scientist called Giacomo Rizzolatti came across and articulated the concept of Mirror Neurons, the general idea being that "mirror neurons" become active in our brain by observing (or even reading) about other people's behaviours. The brain actually responds as if we were doing the observed behaviour.
To see more on this, please go to www.mindsways.com/SMS/
WHO STILL BELIEVES IN MAGIC?
You may think that you don't believe in magic in any way or form., but if we take a closer look at ourselves, we are surrounded by ritual, superstitions and the belief in invisible forces. I have sat with government officers, scientists, CEOs and whole mixture of people, and one phrase quickly shows the magical beliefs that abound: "touch wood".
At its mere mention you can see people desperately looking around for wood. How many of us have lucky charms, rituals we go through before exams, interviews, meetings etc. ? As people, we want to believe that there is something beyond, that there are invisible forces that impose order in the world.
There are many reasons that lie behind why we believe weird things. One is that we want to be in control. In fact the more uncertainty and unpredictable our situations become the more we grope for control. Mind Magic, otherwise known as mentalism, uses the idea that strange things are afoot. For more information on this or anything else in this newsletter, please see www.mindsways.com/SMS/
ENTER THE MIND MAGICIAN
We have a deep seated need for status, control and mystery. The Mind Magician (and mentalists like Derren Brown) are experts at tapping in to and meeting this need, especially as many think it may just be real. Regardless of how many rational explanations are made that it's based on psychology and trickery, our need for control and our beliefs in invisible forces rejects the rational in favour of the emotional. The mirror neurons are stirring in us and the needs for mystery are met through Mind Magic. This is why Mind Magic has held its popularity over the last 100 years.
The tools, techniques and ideas accrued are all very clever, some simpler than others but all share this rich tradition. Some of this tradition is the passing on and teaching of these ideas on days like the SMS. To see more about the rich history and tradition, please see www.mindsways.com/SMS/
INFORMATION ALONE IS NOT MOTIVATION
Your message to motivate others has to make an impact and leave an impression. Otherwise no actions will follow from it. To do this we have to think carefully about how we get our message across. In doing this "show me" is more powerful than "tell me". This is why we focus so much on the Show Not Tell (SNT) philosophy.
Visual illusions are real-world demonstrations of how our minds work. Because of their subjective nature, illusions are powerful expressions of we fail to match what we see to the real world around us. This is what the SNT kit shows.
The SNT kit is designed to give you a sense and understanding of what is going on beneath the surface, allowing you to grasp the psychology of every illusion. A strong visual illusion makes you;
See something that isn't there
Fail to see something that is, or
See something different to what is there
Remember, you can't believe what you see, but you see what you believe. It's easy to imagine that these illusions happen only on pieces of paper, on computer screens or during magic tricks; easy, but wrong. They're significant in all areas of our lives, affecting;
Our Identity (How you see yourself)
Our Aspirations (What you want to do in life)
Our Drives (Why you get out of bed in the morning)
Our Ambitions (Where you want to go)
Our Personality (Who you are)
And our very essence. Illusions, then, play a critical role in your life and in everyone else's. They determine how you act, behave and think. On the day, you also receive your own copy of the SNT kit, for more information, see www.mindsways.com/SNT/
Psychological Artistry and Mind Magic has at its core the idea of showing, not just telling. Imagine any magic trick where the magician just described what was happening. This also brings to the fore the idea of ensuring Multiple Moments of Interest (MMI's) as part of your message. These are Multiple Moments of:
Interest
Interaction
Insight
Imagine then taking this and combing it with ideas from "Thought Leadership" such as:
Focus creating clarity
Clarity showing power
Power giving you understanding
Understanding giving you certainty
Certainty leading to trust
Trust leading to actions
On the Sleight of Mind Set workshop, we use Psychological Artistry and Mind Magic as a means and a prism for looking at these ideas. Please go to www.mindsways.com/SMS/ for more.
PSYCHOLOGICAL ARTISTRY
The approach we take is what we call Psychological Artistry and involves using a blend of psychology, mind magic (or mentalism), personal development and smart thinking ideas. By tapping into people's imagination, curiosity and desire for mystery we can engage people in all different areas. By adding in psychological approaches, this is strengthened. I appreciate that by its very nature, it is not a traditional approach but that is where its power lies.
Interesting examples of how all is not as it appears are the McGurk effect, Richard Wiseman's "The Incredible Colour Changing Card Effect" and a twist on a classic Fred Astaire routine. I would love to know what you think. These illustrate both the power and the approach of Psychological Artistry. Please take a look here or go to mindsways.com/SNT/
WHAT DO YOU GET ON THE WORKSHOPS?
As well as learning the tricks, tools, techniques and ideas behind Mind Magic and Psychological Artistry from the day, you will get to take away with you:
The SMS Pack :- The materials you need to perform the tricks we go through on the day as well as a number of extras
The SNT Kit :- A pack of astounding and effective materials that can be used anytime, anywhere. For more information on this, please go to www.mindsways.com/SNT/
The Support Materials :- A 2 hour DVD that shows you through the kit, how to use it and background information. This is also available online.
The Presentation :- A copy of the presentation we use on the day for your reference
The eBook :- Written materials on the tricks, including scripts and how to use them
Follow-up Support :- Contact with the trainers for further support and advice
To learn more about the content of the workshop and any of the items above, please go to www.mindsways.com/SMS/
WHAT DO PEOPLE SAY ABOUT THE WORKSHOPS?
Over the past two years of delivering these workshops, the feedback from these has been extremely positive, with people from recent workshops saying things like:
"It really was most enjoyable and enlightening"
"The most unique training day I have ever been on"
"My target was to get 3 things to add to my training, I had 11 by lunchtime"
"Fantastic day... a great eye opener!"
"Thanks to you both for a challenging, stimulating and enjoyable day"
"I've had plenty of thoughts about how some of the approaches used might be incorporated into several areas of my work"
"A great course, with plenty to think about and over"
For more on what people say, please see www.mindsways.com/what-people-say/ and for more on the workshops themselves, please go to www.mindsways.com/SMS/
BOOKING YOUR PLACE
Overall, the workshops:
Acts as a catalyst for your future development
Are for people who are curious,
Add new skills to you
Enable you to apply the techniques and ideas from Psychological Artistry and Mind Magic
Act as a source of inspiration
Provide key insights in to the Power of Perspectives
Bridges the Creativity Gap,
Look at Innovation, creativity and creating extraordinary moments
Shows the power of Personal Touch,
Highlights the importance of Show, Not Tell
Using the materials from the SNT kit and the Sleight of Mind Set workshop, you will find a wealth of practical, real world techniques that can be applied to coaching, training, consultancy, presenting, business, personal development and therapy. To register your place on the Sleight of Mind Set Workshop, please click here to go to www.mindsways.com/SMS
Thanks
George
P.S. The Show, Not Tell kit is available separately. For more on what the SNT kit is and what it does, please see www.mindsways.com/SNT/
P.P.S. We are now offering a number of bespoke Mindstwist events for organisations and businesses. These take place in-house or during conferences, meetings or during organisational events. They range from Talks, Workshops, Performances and Shows. For more information on our new range of Mindstwist Events, please see www.mindsways.com/mindstwist-events/
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nEUROn, drone de combat DASSAULT AVIATION
la première fois dans l’histoire de l’aéronautique mondiale qu’un appareil furtif contrôlé depuis le sol évolue en public
this is what it's made up of, your brain that is - now whether it's your mindstuff is another question.
Les astrocytes sont des cellules en forme d'étoile dont la fonction est de fournir les nutriments nécessaires et réguler l'environnement chimique des neurones, ainsi que de contrôler et moduler l'activité de ces derniers. Ici on peut visualiser des astrocytes en culture (en vert), dérivés de modèles murins (souris) de la maladie de Steinert, qui se caractérise notamment par une accumulation d’agrégats d’ARN toxiques (acide ribonucléique chimiquement proche de l'ADN dont il est issu, visualisé ici en rouge) dans le noyau (en bleu) de ces cellules.
©Inserm, Agence National de Recherche, AFM-Téléthon.licence CC-BY-NC 4.0 international
En savoir plus :
(), ́ , est une maladie neuromusculaire héréditaire qui touche des patients de tous âges. S’il s’agit d’une pathologie rare, elle fait tout de même partie des myopathies les plus fréquentes, touchant 5 000 à 8 000 personnes vivant en France.
L'altération des cellules neuronales et non neuronales est fréquemment impliquée dans les maladies neurologiques, comme la maladie de Steinert. Cependant, les cellules non neuronales font plus rarement l’objet de recherches.
Dans une étude, publiée en 2022 dans Nature Communications, des scientifiques de l'Inserm ont démontré pour la première fois l’implication dans la maladie de Steinert des astrocytes, des cellules cérébrales qui ont longtemps été considérées comme de simples cellules de soutien des neurones. Ce travail, mené chez des souris modèles de la pathologie, révèle des dysfonctionnements au niveau des astrocytes, dans lesquelles s’accumulent des agrégats d’ARN toxiques.Ces agrégats auraient notamment un effet délétère sur la morphologie complexe et ramifiée des astrocytes, ce qui pourrait compromettre leur capacité à soutenir et à réguler la fonction synaptique (qui permet la transmission de l'information d'un neurone à l'autre) dans le cerveau.
Hoy es raro
como bueno y malo
estas lineas se deben a que soy mujer, estos dias afectan mis neuronas
Hoy, ayer y antes de ayer siento mi fracaso
prefiero no pensarlo, asi no lo siento tanto, pero basta que mi cabeza me traicione y en 5 segundos estoy destruida llorando.
Me gusta llorar, pero cuando no tengo pintura en los ojos.
No me gusta limpiarme la cara despues de llorar.
Tampoco me gusta llorar en la noche, por la mañana mis ojos no se ven bien, son dos pelotas de golf.
Tengo que usar anteojos, no me gusta usarlos, veo todo negro.
Tampoco me gusta llorar cuando tengo pesadillas, el sabado desperte llorando, preocupada pensando que te habias muerto.
Me dio pena, eres pequeño y fragil, no mereces morir.
Antes dije que me gusta llorar, pero ahora creo que no. No, no , no, no me gusta!
Quiero llorar contigo, seria entretenido.
Quiero comer natur de arroz con un jugo kapo de frambuesa.
Nadie tiene de frambuesa, mejor no busco mas.
Quiero plata, es la unica forma de no sentirme tan fracasada y volver a empezar.
No volvere a empezar, solo seguire.
Quiero seguir, no volver a empezar.
Siempre imagino como sera mi vida, no quiero imaginar mas.
No quiero que sea navidad, no hay nada que celebrar.
No quiero nada. Quiero todo.
Quiero dejar de flotar no sabiendo que sigue.
Si resulta lo que quiero, seria bueno. Seria buena, Si soy buena y tras un buen par de años exitosa, la gente se preguntara... en que universidad estudio esa educadora?? o solo me admiraran por lo buena que soy sin importarles cual fue mi puntaje en la puta psu? Odio la psu, me traiciono, quiero que a ti te vaya bien, al comienzo a uno igual le importa los mil puntos xq la sociedad nos hace creer que unos puntos nos hace mejores que otros, pero yo no creo eso.
Si me esfuerzo soy buena, si no, no y punto. Tampoco me quejo, tan mala no fui. "Logre" quedar en una estatal (y que?) fue lindo ver en el computador esa noticia, fue lindo ver la cara de mi mama. No fue lindo lo que seguio. No fue lindo hundirme, esos dias no fueron lindos.
Si me dieran a eligir, ubiera preferido no haber visto lo que en su momento fue lindo jamas.
Lalala, No me importa la psu, no me importa quien sale presidente, no me importas tu y no me importa la gente.
Me importa mi mundo y las personas que son contadas con una mano que son importantes para mi.
La boca hace meses me traiciono, me senti idiota, como siempre.
Asi que cuando tenga mi titulo en mano hablare, no antes.
Me importa estudiar y ser alguien en la vida. Me importa que no me falte el pan, me importa vivir normal.
No me importan los lujos, ni los autos y las casas gigantes.
Me importa mi vida y si es mejor de lo que quiero no me desagrada.
Me gusta morder el vaso de plastico que tengo en la mano.
Me gusta ver el club de la comedia, veo yingo, no me gusta que me guste ver yingo, pero si me gusta que me guste el club de la comedia.
No quiero ver television, quiero ver todas las teleseries.
No me gusta el miau de mi gato.
No me gusta que mi gato se ponga sobre el teclado me hace escribir puras to.n`´t-´-.ee´´r´as
Gene changes after nerve injury shed light on chronic pain conditions. Uninjured trigeminal neurons (left) had higher expression of genes—such as Trpv1 (green)— related to sensory detection and signaling. After injury (right), Trpv1 expression decreased, while expression of genes linked to nerve damage and regeneration—such as Atf3 (red)—increased.
Learn more: www.nidcr.nih.gov/news-events/nidcr-news/2019/new-view-ne...
Elm
BY SYLVIA PLATH
For Ruth Fainlight
I know the bottom, she says. I know it with my great tap root:
It is what you fear.
I do not fear it: I have been there.
Is it the sea you hear in me,
Its dissatisfactions?
Or the voice of nothing, that was your madness?
Love is a shadow.
How you lie and cry after it
Listen: these are its hooves: it has gone off, like a horse.
All night I shall gallop thus, impetuously,
Till your head is a stone, your pillow a little turf,
Echoing, echoing.
Or shall I bring you the sound of poisons?
This is rain now, this big hush.
And this is the fruit of it: tin-white, like arsenic.
I have suffered the atrocity of sunsets.
Scorched to the root
My red filaments burn and stand, a hand of wires.
Now I break up in pieces that fly about like clubs.
A wind of such violence
Will tolerate no bystanding: I must shriek.
The moon, also, is merciless: she would drag me
Cruelly, being barren.
Her radiance scathes me. Or perhaps I have caught her.
I let her go. I let her go
Diminished and flat, as after radical surgery.
How your bad dreams possess and endow me.
I am inhabited by a cry.
Nightly it flaps out
Looking, with its hooks, for something to love.
I am terrified by this dark thing
That sleeps in me;
All day I feel its soft, feathery turnings, its malignity.
Clouds pass and disperse.
Are those the faces of love, those pale irretrievables?
Is it for such I agitate my heart?
I am incapable of more knowledge.
What is this, this face
So murderous in its strangle of branches? -
Its snaky acids hiss.
It petrifies the will. These are the isolate, slow faults
That kill, that kill, that kill.
^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^
Located further along the same road at George's Dock Gates near to the Liver Building in Liverpool was the River of Light display exhibit Neuron. A display with lines of light at different angles which would either change colour or switch on and off, I attempted a zoom out mid shot to create extra lines of light.
¿ nyur-uh-KANTH-us ? -- Greek: neuron (vein, nerve); ákantha (thorn, spine); spiny vein ... Dave's Botanary
sfay-ro-STAY-kee-us -- sphaero (round, globe shaped); stachyus (flower spikes) ... Dave's Botanary
commonly known as: pin cushion flower • Gujarati: ગંઠેર ganthera • Hindi: पुतलियो putliyo • Kachchhi: ગંઢારો gandharo • Kannada: ಸೂಜಿಮೆತ್ತೆ ಹೂವು sujimette hoovu • Konkani: घोशवे ghoshve • Marathi: घोसवेल ghosvel, गोलगोंडा golgonda
botanical names: Neuracanthus sphaerostachyus (Nees) Dalzell ... homotypic synonyms: Lepidagathis sphaerostachya Nees ... heterotypic synonyms: Neuracanthus lawii Wight ... and more at POWO, retrieved 06 July 2025
NOTE: Orthographic variant: Neuracanthus sphaerostachys (Nees) Dalzell
~~~~~ DISTRIBUTION in INDIA ~~~~~
Goa, Gujarat, Karnataka, Maharashtra, Nagar Haveli, Rajasthan; endemic
Names compiled / updated at Names of Plants in India.
made for a friend's wedding gift. details blogged here!
is-five.blogspot.com/2010/02/anatomical-day-of-week-tea-t...
Oligodendrocytes (cellules protectrices des neurones) présentant une accumulation de la protéine α-synucléine, caractéristiques de l'atrophie multisystématisée.
©Arotcarena et al./Inserm.licence CC-BY-NC 4.0 international
En savoir plus :
Les synucléinopathies sont des maladies neurodégénératives caractérisées par l’accumulation, au sein des cellules du système nerveux central, d'agrégats de la protéine α-synucléine. La maladie de Parkinson est la plus répandue, avec une accumulation de l’α-synucléine localisée au sein des neurones. Vient ensuite l’atrophie multisystématisée, caractérisée par l’accumulation de l’α-synucléine au sein des cellules protectrices des neurones, les oligodendrocytes (en photo ici). L’accumulation pathologique de l’α-synucléine dans ces cellules joue un rôle important dans la mort des neurones. Dans un article paru en août 2019 dans la revue JCI insight, l'équipe des chercheurs Inserm Benjamin Dehay et Erwan Bezard, présente une stratégie thérapeutique ayant pour but d’augmenter l’élimination de l’α-synucléine grâce à l’activation d’un des systèmes de dégradation des protéines (autophagie). Pour ce faire, les chercheurs ont ciblé spécifiquement les cellules affectées dans des modèles animaux de ces deux maladies. Ils ont démontré qu’un ciblage spécifique dans les neurones, pour la maladie de Parkinson, et dans les oligodendrocytes, pour l’atrophie multisystématisée, s'avérait être une stratégie efficace pour réguler la mort des neurones. L'équipe montre ainsi pour la première fois l’intérêt de jouer sur la dégradation de l’α-synucléine en ciblant spécifiquement les cellules où elle s'aggrège, ce qui en fait une piste thérapeutique intéressante pour ces maladies neurodégénératives.
I thought Neuron was the true companion for the Moebius Band! The Challenge was to use the Moebius Syndrome Foundation's logo as our string to raise awareness for this disorder. Each year on January 24th it's Moebius Syndrome Awareness Day. Purple is the colour for MSAD.
The images represent confocal reconstructions of hippocampal neurons grown on 3D-Scaffold.
The cultures were first immunolabelled for β-tubulin III (in red) in order to visualize the neurons; Glial Fibrillary Acidic Protein (GFAP, in green) to visualize glial cells and DAPI (in blue) for nuclei. The images were acquired using a sophisticated Laser-Scanning Confocal Microscope for viewing samples in 3D, which is not possible in standard microscopes.
The 3D renderings demonstrate that the cells grown on such substrates are capable of migrating and forming connections in all spatial configurations, thus overcoming the constraints imposed by culturing on flat surfaces. The reconstructions are of neurons and glial cells spreading through a thickness of 60-100 micron (consider that the size of neuronal soma is around 10 micron). Using this highly technological approach we were able to appreciate that the cells and their processes were not simply anchored to the scaffold but were in fact navigating the pores present in the 3D-structure.