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Sur cette image de neurone d’hippocampe de rat, obtenue en microscopie confocale après 7 jours en culture (in vitro), on observe les détails des compartiments du neurone permettant la transmission d'une information au sein du cerveau. En magenta, on peut distinguer les dendrites (ramifications) d'un neurone qui recueillent de l’information et en cyan la partie proximale de l'axone, une extension unique du neurone, qui propage l'information depuis le corps jusqu'aux terminaisons nerveuses (ou synapses).
Cette image est extraite d'un travail mené par une équipe de chercheurs de l'Inserm qui cherche à mieux comprendre les troubles du développement neurologique (TND). Ces troubles entrainent des pathologies telles que les troubles du spectre autistique (TSA) ou l'épilepsie. Les résultats de leurs recherches rapportent que lorsque la protéine Prickle 2 est défectueuse, différents compartiments du neurone sont affectés ce qui entraîne une mauvaise transmission d'information. Ces défauts peuvent avoir des conséquences sur l’efficacité des approches thérapeutiques actuellement proposées pour les TND. Les avoir repérés et avoir identifié cette protéine défectueuse est un pas de plus vers la mise au point de thérapies plus efficaces.
© Ana Dorrego-Rivas et Mireille Montcouquiol /Inserm.licence CC-BY-NC 4.0 international
Source : The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling, ScienceAdvances, 9 septembre 2022
EXPLORE, EXPERIENCE AND WONDER
Activities to stimulate, inspire and amuse your little grey cells....
Art and Science on the Brain
Wonder Street Fair 7-9 April 2013
Barbican Centre, London
Festival of Neuroscience - BNA 2013
A unique experience with outstanding speakers presenting the latest developments in research into the brain and CNS organised by British Neuroscience Association and supported by Wellcome Trust
La myéline est une substance qui enrobe l'axone, extension unique du neurone, qui propage l'information depuis le corps jusqu'aux terminaisons nerveuses (ou synapses). La myéline isole l'axone et permet d'accélérer la vitesse de transmission de l'information électrique qui le parcourt. Certaines maladies auto-immunes comme la sclérose en plaque se manifestent par la dégradation de cette gaine.
On observe ici la région cérébrale où se produit classiquement la démyélinisation suite à une attaque du système immunitaire similaire à ce qu'on peut observer dans les pathologies auto-immunes dégradant la gaine de myéline.
Les cellules visualisées en rouge correspondent à l’ensemble des cellules microgliales - cellules du système immunitaire (macrophages) spécifiques du système nerveux central -, qui présentent des propriétés inflammatoires se manifestant juste après la démyélinisation. Lorsque le processus de régénération spontanée de la myéline est efficace, le caractère inflammatoire des cellules microgliales s’atténue ensuite au profit d’un caractère anti-inflammatoire et pro-régénératif. Les cellules visualisées en vert sont une sous-population de ces cellules microgliales qui deviennent anti-inflammatoires.
© Zahaf et al./Inserm U1050.licence CC-BY-NC 4.0 international
En savoir plus :
La sclérose en plaques est une maladie auto-immune pour laquelle il n’existe pas encore de traitement curatif. Une de ses particularités est de toucher trois femmes pour un homme. Des scientifiques se sont donc intéressés au rôle des hormones sexuelles pour mieux comprendre les différences entre hommes et femmes face à cette maladie. Ils ont réussi à montrer que même s’ils ne sont présents qu’en faible quantité chez les souris femelles, les hormones mâles appelées androgènes (qui favorisent le développement des organes génitaux externes, la formation du sperme et l'apparition des caractères sexuels secondaires) ont bien une action favorisant une régénération optimale de la myéline détruite.
Ces résultats mettent en lumière la nécessité de prendre en considération le sexe du patient dans l’approche thérapeutique de cette pathologie. Ils pourraient aussi ouvrir de nouvelles pistes de traitements pour d'autres pathologies altérant la gaine de myéline du système nerveux central.
Sources : Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination, Nature communications, mars 2023 : doi.org/10.1038/s41467-023-36846-w
Authors: Xavier Figueroa and Albert Folch (Univ. of Washington, Bioeng. Dept.)
For details, see Tourovskaia, A., Barber, T., Wickes, B., Hirdes, D., Grin, B., Castner, D. G., Healy, K. E., and Folch, A. "Micropatterns of Chemisorbed Cell Adhesion-Repellent Films Using Oxygen Plasma Etching and Elastomeric Masks", Langmuir 19, 4754 (2002).
It's a brainbow! Welcome to the human brain! No, it's not this color, ha ha. This is for a neuroscience poster for my department :)
(side note: All brain images were taken from consenting indviduals OR donor organs...I did not steal them out of medical files or offline, ha ha)
EXPLORE, EXPERIENCE AND WONDER
Activities to stimulate, inspire and amuse your little grey cells....
Art and Science on the Brain
Wonder Street Fair 7-9 April 2013
Barbican Centre, London
Festival of Neuroscience - BNA 2013
A unique experience with outstanding speakers presenting the latest developments in research into the brain and CNS organised by British Neuroscience Association and supported by Wellcome Trust
Messe Basel's new fair buildings (Hall 1), designed by Herzog & de Meuron architects. Video: vernissage.tv/blog/2013/04/27/herzog-de-meuron-architects...
The last SUBDUB of 2011 hosted at Vox, Leeds.
Iration Steppas sound in the main room, with Neuron Pro Audio room 2 and Central Beatz sound in room 3.
Huge selection of DJs playing everything from dub reggae, drum & bass, dubstep and bashment. Roll on 2012!
In higher acuity environments, such as the ICU or OR, continuous collection of vital signs data is required. When hospitals implement electronic medical charting through device integration in these environments, the collection of vital signs is automated thereby allowing nursing staff to spend more time on direct patient care, assessment and surveillance.
Capsule's solution is typically deployed in high acuity environtments by mounting the Capsule Neuron on the wall, near the patient. The Capsule Neuron then manages the collection of all vital signs from all devices for that patient. Electronic Medical Charting. The visual display at the bedside provides clinicians with continuous assurance that all patient data is being collected from connected devices and automatically being sent to the EMR waiting for validation when the clinician has time to chart.
Vélo de compétition des années 2000.
Equipé en Campagnolo - Composants à revoir
Cadre original et très rigide
Hauteur Axe en Axe 54
Longueur Axe en Axe 57
NIDCR and NCCIH researchers developed an innovative strategy for linking two powerful but disconnected approaches for classifying neurons: single cell RNA-sequencing, which defines neurons according to the expression of hundreds of genes, and in vivo functional imaging, which characterizes groups of neurons according to their activity.
Learn more: www.nccih.nih.gov/research/research-results/new-insights-...
Courtesy of Matt Abramian
matthew.abramian@gmail.com
"This was done using Golgi staining...potassium dichromate and silver nitrate. First time doing this for me, so I was super excited to see how cool they looked. Camillo Golgi discovered this technique in the late 19th century...we still use it today cause it allows us to get really good images of synapse morphology."
"first image is the hippocampus, second one is the cortex and the third one is the thalamus"
Benefits of the Capsule Neuron include:
* Continuous assurance that vital signs data are automatically being transmitted from patient devices to enterprise information system(s)
* Immediate alerting at the bedside of connectivity problems for quicker troubleshooting
* Touch screen interface for easy access to additional device connectivity status information and history log of connectivity
* Wireless communication to the server to eliminate the need to pull Ethernet cabling to each bedside, reduce cable clutter, and provider greater flexibility for mounting and deployment
* Capsule’s platform of the future that will be field upgradeable to support an expanding set of solutions to enable improved bedside workflow and enhanced patient safety
by Zhirong Wang
Primary auditory neurons in mice exhibit spontaneous activity before
the animal can hear. This fascinating feature of the sensory system is
thought to help build neural circuits prior to sound input as if
orchestras rehearse before the show. This video captures both
discrete and synchronized spontaneous calcium transients using a
pan-neuronal genetically encoded calcium indicator, snap25-
GCaMP6s, in spiral ganglion neurons acutely dissected out of a
newborn mouse inner ear without any stimulation. Robust signals
spread throughout the neuronal cell bodies, axons, and axonal
terminals. Upon an increase or decrease of intracellular calcium
concentration, the green fluorescence intensity of GCaMP rise and
fall, respectively, as if a grand piano with keys, hammers, and strings
beautifully arranged, stroked, and vibrating is played by invisible
hands.
Cerebellum tissue with clearly visible row of Purkinje cells (type of neurons in cerebellum).
Leitz Orthoplan, 40X objective, brightfield illumination
EXPLORE, EXPERIENCE AND WONDER
Activities to stimulate, inspire and amuse your little grey cells....
Art and Science on the Brain
Wonder Street Fair 7-9 April 2013
Barbican Centre, London
Festival of Neuroscience - BNA 2013
A unique experience with outstanding speakers presenting the latest developments in research into the brain and CNS organised by British Neuroscience Association and supported by Wellcome Trust
apart perhaps from a meteor crashing into the frozen pond, i don't know what creates these -- there were several of them there.
Elm
BY SYLVIA PLATH
For Ruth Fainlight
I know the bottom, she says. I know it with my great tap root:
It is what you fear.
I do not fear it: I have been there.
Is it the sea you hear in me,
Its dissatisfactions?
Or the voice of nothing, that was your madness?
Love is a shadow.
How you lie and cry after it
Listen: these are its hooves: it has gone off, like a horse.
All night I shall gallop thus, impetuously,
Till your head is a stone, your pillow a little turf,
Echoing, echoing.
Or shall I bring you the sound of poisons?
This is rain now, this big hush.
And this is the fruit of it: tin-white, like arsenic.
I have suffered the atrocity of sunsets.
Scorched to the root
My red filaments burn and stand, a hand of wires.
Now I break up in pieces that fly about like clubs.
A wind of such violence
Will tolerate no bystanding: I must shriek.
The moon, also, is merciless: she would drag me
Cruelly, being barren.
Her radiance scathes me. Or perhaps I have caught her.
I let her go. I let her go
Diminished and flat, as after radical surgery.
How your bad dreams possess and endow me.
I am inhabited by a cry.
Nightly it flaps out
Looking, with its hooks, for something to love.
I am terrified by this dark thing
That sleeps in me;
All day I feel its soft, feathery turnings, its malignity.
Clouds pass and disperse.
Are those the faces of love, those pale irretrievables?
Is it for such I agitate my heart?
I am incapable of more knowledge.
What is this, this face
So murderous in its strangle of branches? -
Its snaky acids hiss.
It petrifies the will. These are the isolate, slow faults
That kill, that kill, that kill.
^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^
I made this cake for my friend and lab mate Andy's thesis defense. It was chocolate cake with a white chocolate cream cheese frosting. Yum!
Considering the many neurons comprising a person's brain, it is fitting that the same neurons used to imagine and build and market and maintain and operate a jet airliner (contrail in the sky above the sculpture) also are the same neurons that make possible the concept and creation of this 2010 outdoor sculpture by Roxy Paine at the Meijer Gardens and Sculpture Park in Grand Rapids, pictured (in part) here. See also, www.meijergardens.org/explore/neuron/
Press L for lightbox full-screen; for full-size press Z or click the image.
Hover the mouse for pop-up annotations on the image.
These are typical Golgi stained neurons in the epileptic human dentate gyrus. Even more beautiful viewed large.
Des p'tits neurones dans les cerveaux
Qui disparaissent de jours en jours
Dans les p'tits bois les p'tits discours
Des petits rois dans les basses cours
Des p'tits qui s'cachent des p'tits qu'on cache
Des p'tits qu'on joue à pile ou face
Des p'tits qui vont grossir les ventres
Des p'tits caissiers dans les carrefours
Des p'tits problèmes de récession
Des p'tits ministres dans les prisons
Des p'tits pour payer ton loyer
Des p'tits pour la communauté
Tapez tapez sur les claviers
Des pompes funèbres aux cours d'écoles
Faut voir comme les p'tits sont frigués
Y'a de la griffe sur les guiboles
Des p'tits insectes sur les fleurs
Des p'tits bugs dans le computer
Des p'tits pour l'eau des p'tits pour l'air
Des p'tits pour pourrir l'atmosphère
Marchez marchez les p'tits pinçons
Les petits rois les petits cons
Des p'tits pour vendre qui on est
A la criée sur les marchés