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EXPLORE, EXPERIENCE AND WONDER
Activities to stimulate, inspire and amuse your little grey cells....
Art and Science on the Brain
Wonder Street Fair 7-9 April 2013
Barbican Centre, London
Festival of Neuroscience - BNA 2013
A unique experience with outstanding speakers presenting the latest developments in research into the brain and CNS organised by British Neuroscience Association and supported by Wellcome Trust
This image shows neurons In The Nucleus of the Solitary Tract (NTS) of the rat brain that have been stained using immunohistochemistry. 5-HT2A receptors have been stained in red and Beta-Tubulin III (a neuronal marker) is shown in green. The NTS acts to regulate homeostatic mechanisms essential in a wide variety of bodily functions such as cardiovascular control and reflexes. It is part of widespread neuronal circuitry and forms reciprocal connections with many other regions of the brain.
This image reflects the magnificent layout and interplay of the neurons in a rat brain. If you look closely you can see the circular bodies of the neuron that glow in red, fit into the spaces made by the green Beta-Tubulin III marker. It is reminiscent of the intricate threads of a carpet intertwining into each other to give a beautiful display of colours.
This image was created using immunohistochemistry. 5-HT2A rabbit polyclonal antibodies, Beta-Tubulin III mouse monoclonal antibodies and fluorescent dyes were used. Images were then collected using an Olympus TIRF confocal microscope with appropriate excitation lasers.
This picture in particular strikes me because this is a beautiful visual illustration of how different receptors in the brain interact and complement each other to function. It helps you appreciate that despite the millions of neurons and their infinite connections there is an underlying organisation and meaning. This stunning visual display is reminiscent not only of a carpet but of a rose bush, reminding us that these layouts and patterns are all around us. It is a reminder of the ability and power of science and research to uncover these patterns and meanings.
La myéline est une substance qui enrobe l'axone, extension unique du neurone, qui propage l'information depuis le corps jusqu'aux terminaisons nerveuses (ou synapses). La myéline isole l'axone et permet d'accélérer la vitesse de transmission de l'information électrique qui le parcourt. Certaines maladies auto-immunes comme la sclérose en plaque se manifestent par la dégradation de cette gaine.
On observe ici la région cérébrale où se produit classiquement la démyélinisation suite à une attaque du système immunitaire similaire à ce qu'on peut observer dans les pathologies auto-immunes dégradant la gaine de myéline.
Les cellules visualisées en rouge correspondent à l’ensemble des cellules microgliales - cellules du système immunitaire (macrophages) spécifiques du système nerveux central -, qui présentent des propriétés inflammatoires se manifestant juste après la démyélinisation. Lorsque le processus de régénération spontanée de la myéline est efficace, le caractère inflammatoire des cellules microgliales s’atténue ensuite au profit d’un caractère anti-inflammatoire et pro-régénératif. Les cellules visualisées en vert sont une sous-population de ces cellules microgliales qui deviennent anti-inflammatoires.
© Zahaf et al./Inserm U1050.licence CC-BY-NC 4.0 international
En savoir plus :
La sclérose en plaques est une maladie auto-immune pour laquelle il n’existe pas encore de traitement curatif. Une de ses particularités est de toucher trois femmes pour un homme. Des scientifiques se sont donc intéressés au rôle des hormones sexuelles pour mieux comprendre les différences entre hommes et femmes face à cette maladie. Ils ont réussi à montrer que même s’ils ne sont présents qu’en faible quantité chez les souris femelles, les hormones mâles appelées androgènes (qui favorisent le développement des organes génitaux externes, la formation du sperme et l'apparition des caractères sexuels secondaires) ont bien une action favorisant une régénération optimale de la myéline détruite.
Ces résultats mettent en lumière la nécessité de prendre en considération le sexe du patient dans l’approche thérapeutique de cette pathologie. Ils pourraient aussi ouvrir de nouvelles pistes de traitements pour d'autres pathologies altérant la gaine de myéline du système nerveux central.
Sources : Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination, Nature communications, mars 2023 : doi.org/10.1038/s41467-023-36846-w
Authors: Xavier Figueroa and Albert Folch (Univ. of Washington, Bioeng. Dept.)
For details, see Tourovskaia, A., Barber, T., Wickes, B., Hirdes, D., Grin, B., Castner, D. G., Healy, K. E., and Folch, A. "Micropatterns of Chemisorbed Cell Adhesion-Repellent Films Using Oxygen Plasma Etching and Elastomeric Masks", Langmuir 19, 4754 (2002).
It's a brainbow! Welcome to the human brain! No, it's not this color, ha ha. This is for a neuroscience poster for my department :)
(side note: All brain images were taken from consenting indviduals OR donor organs...I did not steal them out of medical files or offline, ha ha)
EXPLORE, EXPERIENCE AND WONDER
Activities to stimulate, inspire and amuse your little grey cells....
Art and Science on the Brain
Wonder Street Fair 7-9 April 2013
Barbican Centre, London
Festival of Neuroscience - BNA 2013
A unique experience with outstanding speakers presenting the latest developments in research into the brain and CNS organised by British Neuroscience Association and supported by Wellcome Trust
Entry in category 1. Object of study; Copyright CC-BY-NC-ND: Brian McCabe
Establishing with precision the quantity and identity of the cell types of the brain is a prerequisite for a detailed understanding of nervous system function. However precise quantitation of brain cell numbers has proven difficult to do manually and had only previously been achieved for the nematode c.elegans, which has 302 neurons. Using new genetic tools designed for computer-assisted science, we quantitated the exact number of cells in the entire Drosophila third instar larval central nervous system (CNS), an important model organism. We found less neurons (~10,300) and many more glia cells than previously predicted. We also unexpectedly found that female larva had ~10% more neurons than males. The image shows light sheet images of the ventral nerve cord region of the entire Drosophila larval CNS, with neurons or glia cells labelled. Our findings highlight that when studying behaviour, brain function or even cell numbers, researchers have to consider both sexes.
In higher acuity environments, such as the ICU or OR, continuous collection of vital signs data is required. When hospitals implement electronic medical charting through device integration in these environments, the collection of vital signs is automated thereby allowing nursing staff to spend more time on direct patient care, assessment and surveillance.
Capsule's solution is typically deployed in high acuity environtments by mounting the Capsule Neuron on the wall, near the patient. The Capsule Neuron then manages the collection of all vital signs from all devices for that patient. Electronic Medical Charting. The visual display at the bedside provides clinicians with continuous assurance that all patient data is being collected from connected devices and automatically being sent to the EMR waiting for validation when the clinician has time to chart.
Vélo de compétition des années 2000.
Equipé en Campagnolo - Composants à revoir
Cadre original et très rigide
Hauteur Axe en Axe 54
Longueur Axe en Axe 57
Courtesy of Matt Abramian
matthew.abramian@gmail.com
"This was done using Golgi staining...potassium dichromate and silver nitrate. First time doing this for me, so I was super excited to see how cool they looked. Camillo Golgi discovered this technique in the late 19th century...we still use it today cause it allows us to get really good images of synapse morphology."
"first image is the hippocampus, second one is the cortex and the third one is the thalamus"
Benefits of the Capsule Neuron include:
* Continuous assurance that vital signs data are automatically being transmitted from patient devices to enterprise information system(s)
* Immediate alerting at the bedside of connectivity problems for quicker troubleshooting
* Touch screen interface for easy access to additional device connectivity status information and history log of connectivity
* Wireless communication to the server to eliminate the need to pull Ethernet cabling to each bedside, reduce cable clutter, and provider greater flexibility for mounting and deployment
* Capsule’s platform of the future that will be field upgradeable to support an expanding set of solutions to enable improved bedside workflow and enhanced patient safety
by Zhirong Wang
Primary auditory neurons in mice exhibit spontaneous activity before
the animal can hear. This fascinating feature of the sensory system is
thought to help build neural circuits prior to sound input as if
orchestras rehearse before the show. This video captures both
discrete and synchronized spontaneous calcium transients using a
pan-neuronal genetically encoded calcium indicator, snap25-
GCaMP6s, in spiral ganglion neurons acutely dissected out of a
newborn mouse inner ear without any stimulation. Robust signals
spread throughout the neuronal cell bodies, axons, and axonal
terminals. Upon an increase or decrease of intracellular calcium
concentration, the green fluorescence intensity of GCaMP rise and
fall, respectively, as if a grand piano with keys, hammers, and strings
beautifully arranged, stroked, and vibrating is played by invisible
hands.
Frederick “Rusty” Gage has spent his life asking a question many neuroscientists once considered heretical: can the adult brain grow new neurons?
When I photographed him at the Salk Institute in February 2026, that question felt less like rebellion and more like legacy. We made portraits in his study overlooking the Pacific, a quiet room washed in coastal light. The ocean moved below the cliffs in long, steady breaths. It is the same office once occupied by Jonas Salk, who recruited Rusty decades ago. The desk, the view, the gravity of the place. You feel it immediately. History is not abstract there. It presses in from the walls.
In the late twentieth century, neuroscience was built on a stark premise: you are born with a fixed number of neurons. Damage them and they are gone. Memory fades. Injury lingers. Aging narrows possibility. Rusty challenged that dogma with careful, methodical experiments that showed new neurons could, in fact, form in the adult hippocampus. The implications were enormous. Learning, mood, resilience, even the biology of hope took on new dimensions.
In person, what strikes you first is his attentiveness. He leans in slightly when you speak, hands folded, eyes steady behind round glasses. There is warmth in him that feels unforced. Soft spoken, yes, but never distant. You sense a mind that is constantly mapping connections, not only between neurons but between people. Students drift in and out of his orbit with ease. Colleagues seek him out. He listens more than he declares.
The study itself holds layers of meaning. Jonas Salk built the institute as a place where scientists could think expansively, where architecture and intellect met the horizon. Standing in that room with Rusty, you understand that recruitment was more than a hire. It was a passing of trust. Salk had imagined a future for biology that included imagination and risk. Rusty carried that forward into the living brain.
His work has since expanded beyond neurogenesis into how the genome shapes the nervous system over time. His lab explores mosaicism in the brain, the idea that our neurons are not genetically identical but subtly varied. The brain becomes not a static organ but a dynamic landscape, shaped by experience and by the restless choreography of DNA. It is a vision of the self that is fluid and intricate.
Photographing him in that office felt less like documenting a single scientist and more like tracing a lineage. Salk sought a vaccine that would protect children from paralysis. Rusty sought evidence that the adult brain was not condemned to decline. Both projects required a certain stubborn optimism. A belief that the body holds more possibility than we assume.
The weight of history was there, yes. But so was something lighter. A current of curiosity that refuses to settle. In Rusty Gage’s presence, you feel that science is not a monument. It is a conversation, still unfolding, with the ocean as witness.
NIDCR and NCCIH researchers developed an innovative strategy for linking two powerful but disconnected approaches for classifying neurons: single cell RNA-sequencing, which defines neurons according to the expression of hundreds of genes, and in vivo functional imaging, which characterizes groups of neurons according to their activity.
Learn more: www.nccih.nih.gov/research/research-results/new-insights-...
EXPLORE, EXPERIENCE AND WONDER
Activities to stimulate, inspire and amuse your little grey cells....
Art and Science on the Brain
Wonder Street Fair 7-9 April 2013
Barbican Centre, London
Festival of Neuroscience - BNA 2013
A unique experience with outstanding speakers presenting the latest developments in research into the brain and CNS organised by British Neuroscience Association and supported by Wellcome Trust
Sur cette image de neurone d’hippocampe de rat, obtenue en microscopie confocale après 7 jours en culture (in vitro), on observe les détails des compartiments du neurone permettant la transmission d'une information au sein du cerveau. En magenta, on peut distinguer les dendrites (ramifications) d'un neurone qui recueillent de l’information et en cyan la partie proximale de l'axone, une extension unique du neurone, qui propage l'information depuis le corps jusqu'aux terminaisons nerveuses (ou synapses).
Cette image est extraite d'un travail mené par une équipe de chercheurs de l'Inserm qui cherche à mieux comprendre les troubles du développement neurologique (TND). Ces troubles entrainent des pathologies telles que les troubles du spectre autistique (TSA) ou l'épilepsie. Les résultats de leurs recherches rapportent que lorsque la protéine Prickle 2 est défectueuse, différents compartiments du neurone sont affectés ce qui entraîne une mauvaise transmission d'information. Ces défauts peuvent avoir des conséquences sur l’efficacité des approches thérapeutiques actuellement proposées pour les TND. Les avoir repérés et avoir identifié cette protéine défectueuse est un pas de plus vers la mise au point de thérapies plus efficaces.
© Ana Dorrego-Rivas et Mireille Montcouquiol /Inserm.licence CC-BY-NC 4.0 international
Source : The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling, ScienceAdvances, 9 septembre 2022