View allAll Photos Tagged microscopic
Microscopic Photo. Five enlarged renal tubular epithelial cells with enlarged basophilic nuclei with inclusions. Tubular injury is present. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Sclerosis and narrowing of blood vessel lumens; interstitial fibrosis and mild inflammation; hemosiderin deposition in air spaces and alveolar walls; a few atypical type 2 pneumocytes.
Microscopic Photo. Tubular adenoma with focal high grade dysplasia. The high grade dysplasia shows complex glands and focal intraluminal tumor necrosis. There is no mucosal stromal desmoplastic reaction. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Malakoplakia, a condition often associated with immunodeficiency and characterized by abnormal macrophage function consists of sheets of large histiocytes in response to a bacterial infection. It represents a relatively ineffective inflammatory response because of persistence of bacteria and/or bacterial degradation products within the histiocytes. In the lungs it is almost always caused by infection with Rhodococcus equi but it may be caused by other bacteria. Malakoplakia is morphologically very similar to Mycobacterium avium complex infection in AIDS patients and to Whipples disease and lepromatous leprosy. The distinguishing and diagnostic feature of malakoplakia is the presence of small intracellular concentrically calcified structures called Michaelis-Gutman bodies (MG bodies). MG bodies also contain stainable iron. Intracytoplasmic calcifications not having the typical appearance of MG bodies may also be present.
In this low magnification photomicrograph the lung tissue to the right is occupied by a mixed inflammatory cellualr infiltrte with a predominance of large histiocytes. Relatively uninvolved lung tissue is seen at the left.
Microscopic Photo. The neoplastic glands are lined by hyperchromatic glandular epithelium with elongated nuclei and reduced cytoplasmic mucin production. The normal crypts are at right lower corner. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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In this case only a very small amount of tumor tissue is present. Without the aid of immunohistochemistry the diagnosis would be "non-small carcinoma, NOS". This diagnosis would not be helpful in the selection of targeted therapy. The immunostains (see following) clearly indicate that this is a squamous cell carcinoma.
Microscopic Photo. Gastric antral mass biopsy showing neoplastic intestinal glands resembling colonic adenocarcinoma, consistent with intestinal type gastric adenocarcinoma. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic photo showing cross section of posterior tibial artery with circumferential medial calcifications and 95 % of luminal stenosis. H & E stain. 10X Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Part of a pulmonary blood vessel exhibiting occlusion and recanalization. The nuclei in the fibrous bands that are bridging the lumen do not appear to be those of malignant cells.
Microscopic photo showing all the ducts in sclerosing adenosis are positive for SMMHC with patchy myoepithelial hyperplasia.. IHC stain. 10X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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In this case only a very small amount of tumor tissue is present. Without the aid of immunohistochemistry the diagnosis would be "non-small carcinoma, NOS" This diagnosis would not be helpful in the selection of targeted therapy.The immunostains (see following) clearly indicate that this is a squamous cell carcinoma.
Microscopic photo showing numerous coccobacilli microorganisms. Warthin–Starry Stain 100X oil. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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( microscopic sound )
CD :
( microscopic sound )
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Microscopic photo showing tumor cells from a fine needle aspiration cytology smear. Tumor cells exhibit nuclear features of papillary thyroid carcinoma, including indentation of nuclear envelope, deep nuclear groove, ground-glass (optically cleared or “Orphan Annie eye”) appearance of chromatin, and intranuclear cytoplasmic pseudoinclusions. Papanicolaou's stain. 100X Oil. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic photo. H & E stain. 20X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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20x microscopic image of a coronal section of an embryonic mouse brain.
The tissue was stained with DAPI which interacts with DNA. So every blue oval-circular object is a cell nuclei (that is where most of the DNA is kept)
Some cells were transfected with a plasmid containing a sea jelly (jellyfish) gene which fluoresces green with the correct wavelength of light. This was used to look at stem cells and their descendants at a specific time point.
Microscopic photo showing patchy hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocyte activity. H&E stain. 2X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
Microscopic photo showing transitional cystic epithelial liningin. Clusters of small mucus glands are present in the cystic wall tissue. H & E stain. 20X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA. (乔建华医学博士，美国病理学家学院专家会员。美国加州洛杉矶)
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Microscopic image of a pulmonary corpus amylaceum with central black-brown inclusion. Corpora amylacea are large, round to oval glycoprotein structures that are found within alveoli in a variety of circumstances. They have been reported to be present in up to about 4% of autopsy lungs and are incidental findings with no known clinical significance. They should be distinguished from alveolar microlithiasis. They often contain central inclusions which may appear as black fragments, crystals or ring forms. Prominent central black inclusions said to be birefringent are seen in these structures.
Image contributed by Dr Sanjay Mukhopadhyay - @smlungpathguy
Microscopic photo showing a polypoid benign bladder mucosa with hemorrhage, vascular congestion, and patchy chronic inflammation. H & E Section. Low Power View. Diagnosis: Eosinophilic cystitis. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Approximately 16% of fibrocartilaginous hamartomas of the lung contain structures composed of abundant myxoid or fibroedematous stroma with respiratory epithelial lining resulting in papillary projections resembling immature placental villi. The epithelium lining these projections expresses TTF1 and CK7. Similar structures have also been reported in association with bullous emphysema and lipomatosis.
The Merriam-Webster dictionary definition of transmogrify is "to change or alter greatly and often with grotesque and humorous effect".
Microscopic photo showing solid tumor nodule in omental biopsy tissue. H&E stain. 4X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic Photo. Epithelial disorganization involving lower 1/3 of cervical squamous epithelial lining. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Approximately 16% of fibrocartilaginous hamartomas of the lung contain structures composed of abundant myxoid or fibroedematous stroma with respiratory epithelial lining resulting in papillary projections resembling immature placental villi. The epithelium lining these projections expresses TTF1 and CK7.. Similar structures have also been reported in association with bullous emphysema and lipomatosis.
The Merriam-Webster dictionary definition of transmogrify is "to change or alter greatly and often with grotesque and humorous effect".
Microscopic Photo. Chronic hepatitis C. Reticulin stain demonstrates bridging fibrosis with architectural distortion and cirrhosis (stage 4). Reticulin Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. 0.4 cm bands of degenerate placental basal tissue composed of fibrinoid material and intermediate trophoblast (X cells), necrosis of decidua, and fibrin deposition. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. Left Lung Mass, CT-Guided Needle Core Biopsy Showing: Non-small Cell Carcinoma. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic Photo. Left Lung Mass, CT-Guided Needle Biopsy. Cytology with Pap Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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This typical carcinoid exhibits an insular/organoid growth pattern with small, uniform nuclei containing finely granular chromatin, non-prominent nucleoli and no mitoses. The chromogranin immunostain typically marks these tumors. Other neuroendocrine markers are synaptophysin, CD56 & INSM1.
This is a very instructive case of the small cell variant of squamous cell carcinoma (SCC) mimicking small cell lung carcinoma (SCLC) based not only on morphologic features but also on the results of immunostains. CD56 and CK5/6, the immunostains that were initially obtained were both positive. TTF 1, chromogranin A and synaptophysin were negative. A small percentage of squamous cell carcinomas may express CD56 and a small percentage of high grade neuroendocrine carcinomas may express CK5/6. p63 and p40 stains were subsequently obtained and both were positive confirming the diagnosis of SCC. AE1/AE3 was also positive but did not exhibit the dot like staining of the nuclear membranes that is often seen in SCLC. Careful examination of cell morphology at higher magnifications shows some cells with eosinophilic cytoplasm. Nuclear detail is lacking in these images.
Case contributed by Dr. Jian-Hua Qiao.
This is a very instructive case of the small cell variant of squamous cell carcinoma (SCC) mimicking small cell lung carcinoma (SCLC) based not only on morphologic features but also on the results of immunostains. CD56 and CK5/6, the immunostains that were initially obtained were both positive. TTF 1, chromogranin A and synaptophysin were negative. A small percentage of squamous cell carcinomas may express CD56 and a small percentage of high grade neuroendocrine carcinomas may express CK5/6. p63 and p40 stains were subsequently obtained and both were positive confirming the diagnosis of SCC. AE1/AE3 was also positive but did not exhibit the dot like staining of the nuclear membranes that is often seen in SCLC. Careful examination of cell morphology at higher magnifications shows some cells with eosinophilic cytoplasm. Nuclear detail is lacking in these images.
Case contributed by Dr. Jian-Hua Qiao.
Gallbladder. Microscopic photo: Polypoid mucosal projections with lipid-laden macrophages covered by normal gallbladder epithelium. H & E Stain. Low Power View. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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TTF! immunostain stains the nuclei of compressed glanular structures. A nest of squamous carcinoma (at arrow) is unstained.
Microscopic photo showing tumor cells from a fine needle aspiration cytology smear. Tumor cells exhibit nuclear features of papillary thyroid carcinoma, including indentation of nuclear envelope, deep nuclear groove, ground-glass (optically cleared or “Orphan Annie eye”) appearance of chromatin, and intranuclear cytoplasmic pseudoinclusions. Papanicolaou's stain. 100X Oil. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Gastric Polyp. Microscopic photo: Gastric polyp with dilated glands / microcysts lined by fundic epithelium. H & E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. Cribriform DCIS with low nuclear grade and microcalcifications. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Invasion of the bronchial mucosa by metastatic colonic adenocarcinoma gives the misleading appearance of in situ carcinoma arising in the bronchial epithelium..Uninvolved ciliated bronchial epithelium is present at the right side of the image.
Microscopic Photo. Three enlarged renal tubular epithelial cells with enlarged basophilic nuclei with inclusions. Tubular injury is present. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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