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Example of crocidolite mineral ore as it would naturally appear in environment from a particular location in the Prieska District, Griqualand, South Africa.
Crocidolite, the asbestiform variety of the mineral riebeckite, is also historically known as "blue asbestos" and is one of only five fibrous amphibole minerals currently defined and regulated as "asbestos" (a sixth regulated "asbestos" mineral is the serpentine mineral: chrysotile).
A wide seam or vein of very chatoyant dark blue-grey crocidolite fibers is shown on similarly colored jagged rock matrix. The band of crocidolite's surface exhibits minimal disturbance and preserves its unique ability to reflect light, but its crystal habit is quite asbestiform and can still easily separate into potentially harmful microscopic particles if physically disturbed.
Microscopic photo. H & E stain. 20X. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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“FIGHTING MALARIA---In an improvised laboratory on Guadalcanal, a pharmacist’s mate looks through a microscope, searching for evidence of malaria. U.S. Navy and Marine doctors and technicians are waging constant war against the disease which is prevalent in the tropical zone.”
"Microscopic examination at the hospital."
---
From the Thayer Soule Collection (COLL/2266) at the Archives Branch, Marine Corps History Division
OFFICIAL USMC PHOTOGRAPH
Microscopic photo showing atrophic epidermis, sclerosis of dermis and dermal lymphocyte activity. . H&E stain. 10X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
Microscopic Photo. Epithelial disorganization involving full thickness of cervical squamous epithelial lining. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Intranuclear eosinophilic inclusions surrounded by a clear halo within a intraalveolar multinucleate giant cell.
Contributed by Philip Kane, MD.
Microscopic photo. H & E stain. 10X. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic photo. H & E stain. 4X Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic photo showing patchy hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocyte activity. . H&E stain. 10X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
Microscopic Photo. Left Lung Mass, CT-Guided Needle Biopsy: Non-small cell carcinoma. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. Blood clots is tenuously adherent to placental floor. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. CIN 3 partially involving adjacent endocervical glands. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. Epithelial disorganization involving 2/3 of cervical squamous epithelial lining. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic photo. H & E stain. 20X. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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This bronchial mucosal lesion was found in a lobectomy specimen containing a poorly differentiated large cell carcinoma. The appearance is consistent with moderate dysplasia.
ANY OTHER SUGGESTIONS?
Microscopic Photo. 0.4 cm bands of degenerate placental basal tissue composed of fibrinoid material and intermediate trophoblast (X cells), necrosis of decidua, and fibrin deposition. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo. Left Lung Mass, CT-Guided Needle Core Biopsy Showing: Non-small Cell Carcinoma. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic photo showing a multiloculated liver cyst with fibrotic cystic wall. H & E stain. 4X. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA. (乔建华医学博士， 美国病理学家学院专家会员。美国加州洛杉矶)
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The gumma consists of a central area of coagulative necrosis well demarcated from a peripheral zone of fibrosis containing chronic inflammatory cells. The causative microorganism, Treponema pallidum, cannot usually be found.
Microscopic photo showing tumor cells from a fine needle aspiration cytology smear. Tumor cells exhibit nuclear features of papillary thyroid carcinoma, including indentation of nuclear envelope, deep nuclear groove, ground-glass (optically cleared or “Orphan Annie eye”) appearance of chromatin, and intranuclear cytoplasmic pseudoinclusions. Papanicolaou's stain. 100X Oil. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Placenta. Microscopic photo: Placenta parenchyma with hyalinized villi that have reduced vasculature and infiltration of lymphocytes and macrophages. H & E Stain. High Power View. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic photo showing tumor cells from a fine needle aspiration cytology smear. Tumor cells exhibit nuclear features of papillary thyroid carcinoma, including indentation of nuclear envelope, deep nuclear groove, ground-glass (optically cleared or “Orphan Annie eye”) appearance of chromatin, and intranuclear cytoplasmic pseudoinclusions. Papanicolaou's stain. 100X Oil. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic Photo. Five enlarged renal tubular epithelial cells are positive for CMV antibody stain. IHC Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Intraalveolar papillary growth with a few acinar (glandular) structures at the left side of the image.
Microscopic photo. H & E stain. 10X. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic photo showing nests and aggregates of glomus cells in the soft tissue of a nail bed. Glomus cells are arranged around vessels. H & E Stain. 10X Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA. (乔建华医师，病理学家)
A nodule of splenic tissue attached to the visceral pleura. Splenosis is autotransplantation of splenic tissue following post-traumatic splenic rupture. Splenosis is seen mostly in the abdominal cavity but if there is post-traumatic diaphragmatic rupture and/or a hiatus hernia splenic tissue may gain access to the pleural cavity and become implanted on the pleural surface or, rarely, within the lung, if there is concomitant lung laceration. Thoracic splenosis is almost always asypmtomatic and is usually diagnosed decades following the initial traumatic injury when detected as an incidental finding on a chest imaging study. It always occurs in the left pleural cavity. In this low magnification image there are 2 nodules of lymphoid tissue (white pulp See Notes)surrounded by red pulp. The nodule is encapsulated.
This is a very instructive case of the small cell variant of squamous cell carcinoma (SCC) mimicking small cell lung carcinoma (SCLC) based not only on morphologic features but also on the results of immunostains. CD56 and CK5/6, the immunostains that were initially obtained were both positive. TTF 1, chromogranin A and synaptophysin were negative. A small percentage of squamous cell carcinomas may express CD56 and a small percentage of high grade neuroendocrine carcinomas may express CK5/6. p63 and p40 stains were subsequently obtained and both were positive confirming the diagnosis of SCC. AE1/AE3 was also positive but did not exhibit the dot like staining of the nuclear membranes that is often seen in SCLC. Careful examination of cell morphology at higher magnifications shows some cells with eosinophilic cytoplasm. Nuclear detail is lacking in these images.
Case contributed by Dr. Jian-Hua Qiao.
Microscopic photo showing acute lymphadenitis. H & E Stain 20X. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Captured image showing microscopic chrysotile asbestos fibers and other ambient particles under 400x magnification using Phase-Contrast Microscopy (PCM) optical illumination method.
Although certain technical fiber-counting rules may prohibit identification of specific fiber types using the PCM technique, this example depicts a reference slide with a known type of fiber; in this case, chrysotile asbestos fibers. Note characteristic splitting, curvy lines, narrow width, and splayed ends of the fibers (fiber bundles).
The visible "fibers" in the image are actually bundles of yet further bundles of "fibers". One of the more distinguishing features of asbestos is its incredible capability to subdivide into increasingly smaller and thinner fibers (far beyond the resolution of this microscopy method); until the fiber reaches its ultimate particle size: the individual unit fibril (on the order of angstroms and nanometers).
Among other scientific microscopy applications, PCM is a fairly common, standard analytical technique also utilized for testing air monitoring samples for airborne fiber concentrations pertaining to asbestos-related work, such as projects related to: abatement, repair, clean-up, worker exposure, ambient background, etc.
Further, PCM equipment is relatively inexpensive, portable, and sturdy enough that it can be setup directly on many project sites, a particularly convenient advantage. This testing method is currently so routine, that if one is familiar with an asbestos abatement work project that has occurred or will occur, it's quite likely that PCM air monitoring is involved.
Also depicted is a standardized Walton-Beckett graticule with incremental graduated x-y axes measured in micrometer units; diameter is approx. 100-µm across. Encircling the graticule area are measured scale markers in 3:1 length-to-width aspect ratio for visual reference. The green color is from a green-tinted light interference filter.
Gallbladder. Microscopic Photo: Patchy low grade dysplasia involving flat mucosa, papillae, Rokitansky-Aschoff sinuses. H & E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic photo showing transitional cystic epithelial liningin. Clusters of small mucus glands are present in the cystic wall tissue. H & E stain. 20X objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA. (乔建华医学博士，美国病理学家学院专家会员。美国加州洛杉矶)
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Bladder Biopsy. Microscopic photo: Lamina propria with chronic inflammatory infiltrate with marked eosinophils. H & E Section. High Power View. Diagnosis: Eosinophilic cystitis. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Asteroid bodies are stellate inclusions with numerous rays radiating from a central core that are present in the cytoplasm of giant cells. . They may be be seen in sarcoidosis and other granulomatous disorders. They are most frequently encountered in the giant cells of foreign body granulomas. Multiple asteroid bodies may be present in a single giant cell as seen in this image.
Microscopic Photo. A tubular adenoma with superficial proliferation of neoplastic tubules. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic photo showing tumor cells from a fine needle aspiration cytology smear. Tumor cells exhibit nuclear features of papillary thyroid carcinoma, including indentation of nuclear envelope, deep nuclear groove, ground-glass (optically cleared or “Orphan Annie eye”) appearance of chromatin, and intranuclear cytoplasmic pseudoinclusions. Papanicolaou's stain. 100X Oil. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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In this transbronchial biopsy there are very few foamy alveolar casts.The GMS stain shows typical Pneumocystis cysts.
Asbestos fibers (not seen) coated with iron, resulting in production of characteristic dumbbell-shaped asbestos (ferruginous) bodies. Many of the asbestos bodies are fragmented. Similar structures may be induced by other fibrous minerals.
This alveolus is lined by highly atypical cells some of which have a hobnail appearance. Small nests of invasive adenocarcinoma are seen along the left border.
Gastric Polyp. Microscopic photo: Gastric polyp with dilated glands / microcysts lined by fundic epithelium. H & E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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Microscopic Photo Showing: The tumor is composed of large clear cells with glycogen and distinct margins. H & E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Microscopic Photo. The neoplastic glands are lined by hyperchromatic glandular epithelium with elongated nuclei and reduced cytoplasmic mucin production. H&E Stain. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA
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