View allAll Photos Tagged injectables
Shots from Fallout 4 (the PC game)
Using post-processing injector ReShade + UBER Fidelity Suite preset + a few Nexus mods.
Bonhams , les grandes marques du monde au Grand Palais 2019
Châssis N° 30837S111365
Moteur N° 3111365 F0305RF
•V8 culbuté à soupapes en tête, 327 cid (5 358 cm3)
•Injection mécanique Rochester
•arbre à cames à culbuteurs
•Rare et recherché modèle « Fuelie »
•360 ch à 6 000 tr/min
•Transmission manuelle à 4 rapports
•Suspension indépendante à ressorts hélicoïdaux
•Suspension arrière indépendante à ressort à lames transversal
•Freins à tambour aux quatre roues
Le directeur du style GM, Bill Mitchell, avait engagé Peter Brock et Larry Shinoda pour l'habiller d'une carrosserie Sting Ray spécifique et immédiatement reconnaissable. Avec une ceinture de caisse profondément marquée sous les ailes joliment courbées, elle avait des phares escamotables actionnés électriquement qui préservait ses qualités aérodynamiques.
doté du moteur à culbuteurs L84 327/360 ch, de la transmission manuelle à 4 rapports M20, des roues en alliage à blocage central, d'une radio AM à chercheur de fréquence et du différentiel Posi-Traction 3,73:1.
Le bloc moteur est estampillé des numéros de châssis et de moteur conformes à la configuration du 327/360 ch à injection mécanique Rochester alimentée en air par un collecteur d'admission Winters « snowflake » (un flocon est gravé dans la fonte).
Malgré un surcoût de 430,40 $, les clients de Corvette 1963 achetèrent 2 610 L84, soit 12,1% de la production totale de la Corvette 1963, en principe équipée de la transmission manuelle à 4 rapports facturée, elle, 180,30 $.
The energy injector is like 4000 microwave ovens, another innovative design element of this reactor.
They use a process called radio-frequency heating to ignite the nuclear fuel. These antennae outside the tokamak reactor use a specific frequency of radio waves to excite the particles. The radio waves are calibrated to target just the less abundant material, in this case hydrogen ions. Because the hydrogen accounts for a small fraction of the fuel's total density, focusing the radio-frequency heating on the minority ions allows them to reach extreme energy levels. The excited hydrogen ions then slam into the more abundant deuterium ions, and resulting particles fly into the reactor's outer shell, generating heat and electricity.
And then... "Researchers improved the efficiency of this process by adding helium-3 ions to the mix. The new fuel contains less than one percent helium-3. By focusing all the radio-frequency heating on this trace amount of helium-3, the researchers raised the ions to megaelectronvolt (MeV) energies. An electronvolt is the amount of energy gained or lost when a single electron jumps from a point of electric potential to a point one volt higher, a common unit of measurement for fusion experiments. The new results with helium-3 fuel, generating ions that reach megaelectronvolt energies, has never been achieved before, and the increase in ion energy is a full order of magnitude higher than previous efforts." — Popular Mechanics
injected new life into my old profile photo thanks to gimp and all the the tips and advice from Jenna xXx
Shots from Fallout 4
This was inspired by Dark Tomatoes' shot
www.flickr.com/photos/126266762@N06/23102082224/
Using post-processing injector ReShade + UBER Fidelity Suite preset + a few Nexus mods.
For Christmas, Will sent me a bunch of BA from a recent test run--a really interesting mix of wild fluorescents, trans colors, and metallics. I've been calling the color in this photo "neon metallic green". As you can see, the fluorescent additive in these test colors has the same bright green reaction to UV regardless of what the visible-light color is, although depending on the amount of ambient light and the thickness of the accessory, there is a noticeable tint from the visible-light color even under a blacklight. This is especially pronounced on the neon bronze.
These photos are for a review on the BAF. The Brickarms in the photos are:
1. Production accessories, not BAPs--they're from a test run through a production mold.
2. NON-production colors--while some may resemble current production colors, they are all test runs, and have no official names.
3. Gifts, which means they are ** NOT FOR SALE OR TRADE **.
Small girl inject the Teddy Bear by doctor toy set on the bed in bedroom, Kid, occupation, future, job and health care concept
FINALLY! After days of waiting it's finally arrived. My official bottle of Trump Medical Injectable Bleach! You know it's good when it features one of my favourite quotes from the big man himself "I'm not a doctor but i'm like a person that has good 'you know what" We know you do big fella. Trust us, we know.
In just the days it's taken to move from unsubstantiated claim into production they've even managed to cram in 'added heat and light' and we all know that can only be a good thing when combatting viruses. It even works in under a New York minute. Now that's speedy. Where's my hypodermic? If you want to use it after just let me know...
Cheers
id-iom
Lost in the fury of a psychedelic attack, Nunchuk stands confused. The phoenix passes over him, then seemingly melts into the form of Shadow Tracker.
Nunchuk holds himself, feeling a piercing pain tear through his abdomen as Shadow Tracker lands on the ground beyond the Joe ninja. Shadow Tracker turns to face Nuchuk as the Joe ninja realises that he has been stabbed! Nunchuk grips his side as if he were able to squeeze the searing agony away. He stumbles as Shadow Tracker turns and walks away from the ninja, leaving the Joe for dead.
Session #4 - Right Arm • Sleeve Tattoo
Ganesha is one of the best-known and most widely worshipped deities in the Hindu pantheon. He is widely revered as the Remover of Obstacles and more generally as Lord of Beginnings and Lord of Obstacles, patron of arts and sciences, and the deva of intellect and wisdom. He is honoured at the start of rituals and ceremonies and invoked as Patron of Letters during writing sessions.
Isabelle Villaire
Magnum Tattooing
2317 S. Division Ave.
Grand Rapids, Michigan 49507
Before testing the 3-D printed rocket injector, materials engineers at NASA's Marshall Space Flight Center in Huntsville, Ala., performed a computer tomography scan to ensure the part was fabricated according to the design.
Image credit: NASA/MSFC
Read more:
www.nasa.gov/exploration/systems/sls/multimedia/gallery/3...
www.nasa.gov/exploration/systems/sls/3dprinting.html
More about SLS:
www.nasa.gov/exploration/systems/sls/index.html
Space Launch System Flickr photoset:
www.flickr.com/photos/28634332@N05/sets/72157627559536895/
_____________________________________________
These official NASA photographs are being made available for publication by news organizations and/or for personal use printing by the subject(s) of the photographs. The photographs may not be used in materials, advertisements, products, or promotions that in any way suggest approval or endorsement by NASA. All Images used must be credited. For information on usage rights please visit: www.nasa.gov/audience/formedia/features/MP_Photo_Guidelin...
This section of wall shows the semi circular Davies Tower, built c1160 - 1230. The castle sits on top of a layer of rock known as black crags, similar to that at Lindisfarne. It's part of the Whin Sill, and is a mixture of sedimentary rock injected with a plug of molten rock.
Bamburgh has been a Border stronghold throughout history, so there has been a castle here for hundreds of years. Originally a motte and baily castle, the castle was replaced with stone and the oldest surviving part, the Keep, dates to the C12th.
It was visited by a succession of kings, as well as serving as a prison. Having ceased to be a royal residence, in 1610 James I gave it to Claudius Forster, but he couldn't afford the upkeep, and together with the Civil War destroying parts of the castle, it fell into disrepair.
In 1704 it was bought by Lord Crewe, Bishop of Durham. On his death the Crewe Trust was set up to restore and manage it, and it was used as a library, hospital and school. It was eventually put up for sale again in 1894 and William Armstrong bought it. He was an inventor and engineer and he envisaged it as a home for retired gentlemen. (he also owned Cragside).
Today it is still privately owned by descendants of Armstrong.
Having a new lens to play with, no one to photograph and a pretty flower garland. I headed in to my garden and attempted taking a self portrait.
Injecting technology into our universe.
A wise operation?
Shot in MIlano looking at north towards the Alps, with Rubinar 1000mm and Canon 5D Mark II (video mode)
Music by John Zorn: The Dreamer - Raksasa.
Testosterone
The chemical structure of testosterone.
A ball-and-stick model of testosterone.
Names
IUPAC name
17β-Hydroxyandrost-4-en-3-one
Systematic IUPAC name
(8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Other names
Androst-4-en-17β-ol-3-one
Identifiers
CAS Number
58-22-0 ☑
3D model (JSmol)
Interactive image
ChEBI
CHEBI:17347 ☑
ChEMBL
ChEMBL386630 ☑
ChemSpider
5791 ☑
DrugBank
DB00624 ☑
ECHA InfoCard100.000.336
KEGG
D00075 ☑
PubChem CID
6013
UNII
3XMK78S47O ☑
InChI[show]
SMILES[show]
Properties
Chemical formula
C19H28O2
Molar mass288.431 g·mol−1
Melting point155 °C
Pharmacology
ATC code
G03BA03 (WHO)
License data
EU EMA: by INN
Routes of
administration
Transdermal (gel, cream, solution, patch), by mouth (as testosterone undecanoate), in the cheek, intranasal (gel), intramuscular injection (as esters), subcutaneous pellets
Pharmacokinetics:
Bioavailability
Oral: very low (due to extensive first pass metabolism)
Protein binding
97.0–99.5% (to SHBG and albumin)[1]
Metabolism
Liver (mainly reduction and conjugation)
Biological half-life
2–4 hours[citation needed]
Excretion
Urine (90%), feces (6%)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑ verify (what is ☑☒ ?)
Infobox references
Testosterone is the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.[2] In addition, testosterone is involved in health and well-being,[3] and the prevention of osteoporosis.[4] Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss.
Testosterone is a steroid from the androstane class containing a keto and hydroxyl groups at the three and seventeen positions respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites.[5] It exerts its action through binding to and activation of the androgen receptor.[5] In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. On average, in adult males, levels of testosterone are about 7 to 8 times as great as in adult females.[6] As the metabolism of testosterone in males is more pronounced, the daily production is about 20 times greater in men.[7][8] Females are also more sensitive to the hormone.[9]
In addition to its role as a natural hormone, testosterone is used as a medication, for instance in the treatment of low testosterone levels in men and breast cancer in women.[10] Since testosterone levels decrease as men age, testosterone is sometimes used in older men to counteract this deficiency. It is also used illicitly to enhance physique and performance, for instance in athletes.
Contents
1Biological effects
1.1Before birth
1.2Early infancy
1.3Before puberty
1.4Pubertal
1.5Adult
1.6Aggression and criminality
1.7Brain
2Medical use
3Biological activity
3.1Steroid hormone activity
3.2Neurosteroid activity
4Biochemistry
4.1Biosynthesis
4.2Distribution
4.3Metabolism
4.4Levels
5Measurement
6History
7Other animals
8See also
9References
10Further reading
Biological effects[edit]
In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors.[11] Testosterone can be described as having virilising and anabolic effects (though these categorical descriptions are somewhat arbitrary, as there is a great deal of mutual overlap between them).[12]
Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation.
Androgenic effects include maturation of the sex organs, particularly the penis and the formation of the scrotum in the fetus, and after birth (usually at puberty) a deepening of the voice, growth of facial hair (such as the beard) and axillary (underarm) hair. Many of these fall into the category of male secondary sex characteristics.
Testosterone effects can also be classified by the age of usual occurrence. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone.
Before birth[edit]
Effects before birth are divided into two categories, classified in relation to the stages of development.
The first period occurs between 4 and 6 weeks of the gestation. Examples include genital virilisation such as midline fusion, phallic urethra, scrotal thinning and rugation, and phallic enlargement; although the role of testosterone is far smaller than that of dihydrotestosterone. There is also development of the prostate gland and seminal vesicles.
During the second trimester, androgen level is associated with sex formation.[13] This period affects the femininization or masculinization of the fetus and can be a better predictor of feminine or masculine behaviours such as sex typed behaviour than an adult's own levels. A mother's testosterone level during pregnancy is correlated with her daughter's sex-typical behavior as an adult, and the correlation is even stronger than with the daughter's own adult testosterone level.[14]
Early infancy[edit]
Early infancy androgen effects are the least understood. In the first weeks of life for male infants, testosterone levels rise. The levels remain in a pubertal range for a few months, but usually reach the barely detectable levels of childhood by 4–7 months of age.[15][16] The function of this rise in humans is unknown. It has been theorized that brain masculinization is occurring since no significant changes have been identified in other parts of the body.[17] The male brain is masculinized by the aromatization of testosterone into estrogen, which crosses the blood–brain barrier and enters the male brain, whereas female fetuses have α-fetoprotein, which binds the estrogen so that female brains are not affected.[18]
Before puberty[edit]
Before puberty effects of rising androgen levels occur in both boys and girls. These include adult-type body odor, increased oiliness of skin and hair, acne, pubarche (appearance of pubic hair), axillary hair (armpit hair), growth spurt, accelerated bone maturation, and facial hair.[19]
Pubertal[edit]
Pubertal effects begin to occur when androgen has been higher than normal adult female levels for months or years. In males, these are usual late pubertal effects, and occur in women after prolonged periods of heightened levels of free testosterone in the blood. The effects include:[19][20]
Growth of spermatogenic tissue in testicles, male fertility, penis or clitoris enlargement, increased libido and frequency of erection or clitoral engorgement occurs. Growth of jaw, brow, chin, and nose and remodeling of facial bone contours, in conjunction with human growth hormone occurs.[21] Completion of bone maturation and termination of growth. This occurs indirectly via estradiol metabolites and hence more gradually in men than women. Increased muscle strength and mass, shoulders become broader and rib cage expands, deepening of voice, growth of the Adam's apple. Enlargement of sebaceous glands. This might cause acne, subcutaneous fat in face decreases. Pubic hair extends to thighs and up toward umbilicus, development of facial hair (sideburns, beard, moustache), loss of scalp hair (androgenetic alopecia), increase in chest hair, periareolar hair, perianal hair, leg hair, armpit hair.
Adult[edit]
Testosterone is necessary for normal sperm development. It activates genes in Sertoli cells, which promote differentiation of spermatogonia. It regulates acute HPA (hypothalamic–pituitary–adrenal axis) response under dominance challenge.[22] Androgen including testosterone enhances muscle growth. Testosterone also regulates the population of thromboxane A2 receptors on megakaryocytes and platelets and hence platelet aggregation in humans.[23][24]
Adult testosterone effects are more clearly demonstrable in males than in females, but are likely important to both sexes. Some of these effects may decline as testosterone levels might decrease in the later decades of adult life.[25]
Health risks[edit]
Testosterone does not appear to increase the risk of developing prostate cancer. In people who have undergone testosterone deprivation therapy, testosterone increases beyond the castrate level have been shown to increase the rate of spread of an existing prostate cancer.[26][27][28]
Conflicting results have been obtained concerning the importance of testosterone in maintaining cardiovascular health.[29][30] Nevertheless, maintaining normal testosterone levels in elderly men has been shown to improve many parameters that are thought to reduce cardiovascular disease risk, such as increased lean body mass, decreased visceral fat mass, decreased total cholesterol, and glycemic control.[31]
High androgen levels are associated with menstrual cycle irregularities in both clinical populations and healthy women.[32]
Sexual arousal[edit]
See also: Hormones and sexual arousal
When testosterone and endorphins in ejaculated semen meet the cervical wall after sexual intercourse, females receive a spike in testosterone, endorphin, and oxytocin levels, and males after orgasm during copulation experience an increase in endorphins and a marked increase in oxytocin levels. This adds to the hospitable physiological environment in the female internal reproductive tract for conceiving, and later for nurturing the conceptus in the pre-embryonic stages, and stimulates feelings of love, desire, and paternal care in the male (this is the only time male oxytocin levels rival a female's).[citation needed]
Testosterone levels follow a nyctohemeral rhythm that peaks early each day, regardless of sexual activity.[33]
There are positive correlations between positive orgasm experience in women and testosterone levels where relaxation was a key perception of the experience. There is no correlation between testosterone and men's perceptions of their orgasm experience, and also no correlation between higher testosterone levels and greater sexual assertiveness in either sex.[34]
Sexual arousal and masturbation in women produce small increases in testosterone concentrations.[35] The plasma levels of various steroids significantly increase after masturbation in men and the testosterone levels correlate to those levels.[36]
Mammalian studies[edit]
Studies conducted in rats have indicated that their degree of sexual arousal is sensitive to reductions in testosterone. When testosterone-deprived rats were given medium levels of testosterone, their sexual behaviors (copulation, partner preference, etc.) resumed, but not when given low amounts of the same hormone. Therefore, these mammals may provide a model for studying clinical populations among humans suffering from sexual arousal deficits such as hypoactive sexual desire disorder.[37]
In every mammalian species examined demonstrated a marked increase in a male's testosterone level upon encountering a novel female. The reflexive testosterone increases in male mice is related to the male's initial level of sexual arousal.[38]
In non-human primates, it may be that testosterone in puberty stimulates sexual arousal, which allows the primate to increasingly seek out sexual experiences with females and thus creates a sexual preference for females.[39] Some research has also indicated that if testosterone is eliminated in an adult male human or other adult male primate's system, its sexual motivation decreases, but there is no corresponding decrease in ability to engage in sexual activity (mounting, ejaculating, etc.).[39]
In accordance with sperm competition theory, testosterone levels are shown to increase as a response to previously neutral stimuli when conditioned to become sexual in male rats.[40] This reaction engages penile reflexes (such as erection and ejaculation) that aid in sperm competition when more than one male is present in mating encounters, allowing for more production of successful sperm and a higher chance of reproduction.
Males[edit]
In men, higher levels of testosterone are associated with periods of sexual activity.[41][42]
Men who watch a sexually explicit movie have an average increase of 35% in testosterone, peaking at 60–90 minutes after the end of the film, but no increase is seen in men who watch sexually neutral films.[43] Men who watch sexually explicit films also report increased motivation, competitiveness, and decreased exhaustion.[44] A link has also been found between relaxation following sexual arousal and testosterone levels.[45]
Men's levels of testosterone, a hormone known to affect men's mating behaviour, changes depending on whether they are exposed to an ovulating or nonovulating woman's body odour. Men who are exposed to scents of ovulating women maintained a stable testosterone level that was higher than the testosterone level of men exposed to nonovulation cues. Testosterone levels and sexual arousal in men are heavily aware of hormone cycles in females.[46] This may be linked to the ovulatory shift hypothesis,[47] where males are adapted to respond to the ovulation cycles of females by sensing when they are most fertile and whereby females look for preferred male mates when they are the most fertile; both actions may be driven by hormones.
Females[edit]
Androgens may modulate the physiology of vaginal tissue and contribute to female genital sexual arousal.[48] Women's level of testosterone is higher when measured pre-intercourse vs pre-cuddling, as well as post-intercourse vs post-cuddling.[49] There is a time lag effect when testosterone is administered, on genital arousal in women. In addition, a continuous increase in vaginal sexual arousal may result in higher genital sensations and sexual appetitive behaviors.[50]
When females have a higher baseline level of testosterone, they have higher increases in sexual arousal levels but smaller increases in testosterone, indicating a ceiling effect on testosterone levels in females. Sexual thoughts also change the level of testosterone but not level of cortisol in the female body, and hormonal contraceptives may affect the variation in testosterone response to sexual thoughts.[51]
Testosterone may prove to be an effective treatment in female sexual arousal disorders,[52] and is available as a dermal patch. There is no FDA approved androgen preparation for the treatment of androgen insufficiency; however, it has been used off-label to treat low libido and sexual dysfunction in older women. Testosterone may be a treatment for postmenopausal women as long as they are effectively estrogenized.[52]
Romantic relationships[edit]
Falling in love decreases men's testosterone levels while increasing women's testosterone levels. There has been speculation that these changes in testosterone result in the temporary reduction of differences in behavior between the sexes.[53] However, it is suggested that after the "honeymoon phase" ends—about four years into a relationship—this change in testosterone levels is no longer apparent.[53] Men who produce less testosterone are more likely to be in a relationship[54] or married,[55] and men who produce more testosterone are more likely to divorce;[55] however, causality cannot be determined in this correlation. Marriage or commitment could cause a decrease in testosterone levels.[56] Single men who have not had relationship experience have lower testosterone levels than single men with experience. It is suggested that these single men with prior experience are in a more competitive state than their non-experienced counterparts.[57] Married men who engage in bond-maintenance activities such as spending the day with their spouse/and or child have no different testosterone levels compared to times when they do not engage in such activities. Collectively, these results suggest that the presence of competitive activities rather than bond-maintenance activities are more relevant to changes in testosterone levels.[58]
Men who produce more testosterone are more likely to engage in extramarital sex.[55] Testosterone levels do not rely on physical presence of a partner; testosterone levels of men engaging in same-city and long-distance relationships are similar.[54] Physical presence may be required for women who are in relationships for the testosterone–partner interaction, where same-city partnered women have lower testosterone levels than long-distance partnered women.[59]
Fatherhood[edit]
Fatherhood decreases testosterone levels in men, suggesting that the emotions and behavior tied to decreased testosterone promote paternal care. In humans and other species that utilize allomaternal care, paternal investment in offspring is beneficial to said offspring's survival because it allows the parental dyad to raise multiple children simultaneously. This increases the reproductive fitness of the parents, because their offspring are more likely to survive and reproduce. Paternal care increases offspring survival due to increased access to higher quality food and reduced physical and immunological threats.[60] This is particularly beneficial for humans since offspring are dependent on parents for extended periods of time and mothers have relatively short inter-birth intervals.[61] While extent of paternal care varies between cultures, higher investment in direct child care has been seen to be correlated with lower average testosterone levels as well as temporary fluctuations.[62] For instance, fluctuation in testosterone levels when a child is in distress has been found to be indicative of fathering styles. If a father's testosterone levels decrease in response to hearing their baby cry, it is an indication of empathizing with the baby. This is associated with increased nurturing behavior and better outcomes for the infant.[63]
Motivation[edit]
Testosterone levels play a major role in risk-taking during financial decisions.[64][65]
Aggression and criminality [edit]
See also: Aggression § Testosterone, and Biosocial criminology
Most studies support a link between adult criminality and testosterone, although the relationship is modest if examined separately for each sex. Nearly all studies of juvenile delinquency and testosterone are not significant. Most studies have also found testosterone to be associated with behaviors or personality traits linked with criminality such as antisocial behavior and alcoholism. Many studies have also been done on the relationship between more general aggressive behavior/feelings and testosterone. About half the studies have found a relationship and about half no relationship.[66]
Testosterone is only one of many factors that influence aggression and the effects of previous experience and environmental stimuli have been found to correlate more strongly. A few studies indicate that the testosterone derivative estradiol (one form of estrogen) might play an important role in male aggression.[66][67][68][69] Studies have also found that testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus.[70]
The sexual hormone can encourage fair behavior. For the study, subjects took part in a behavioral experiment where the distribution of a real amount of money was decided. The rules allowed both fair and unfair offers. The negotiating partner could subsequently accept or decline the offer. The fairer the offer, the less probable a refusal by the negotiating partner. If no agreement was reached, neither party earned anything. Test subjects with an artificially enhanced testosterone level generally made better, fairer offers than those who received placebos, thus reducing the risk of a rejection of their offer to a minimum. Two later studies have empirically confirmed these results.[71][72][73] However men with high testosterone were significantly 27% less generous in an ultimatum game.[74] The Annual NY Academy of Sciences has also found anabolic steroid use which increase testosterone to be higher in teenagers, and this was associated with increased violence.[75] Studies have also found administered testosterone to increase verbal aggression and anger in some participants.[76]
Testosterone is significantly correlated with aggression and competitive behaviour and is directly facilitated by the latter. There are two theories on the role of testosterone in aggression and competition.[77] The first one is the challenge hypothesis which states that testosterone would increase during puberty thus facilitating reproductive and competitive behaviour which would include aggression.[77] Thus it is the challenge of competition among males of the species that facilitates aggression and violence.[77] Studies conducted have found direct correlation between testosterone and dominance especially among the most violent criminals in prison who had the highest testosterone levels.[77] The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males.[77]
The second theory is similar and is known as "evolutionary neuroandrogenic (ENA) theory of male aggression".[78][79] Testosterone and other androgens have evolved to masculinize a brain in order to be competitive even to the point of risking harm to the person and others. By doing so, individuals with masculinized brains as a result of pre-natal and adult life testosterone and androgens enhance their resource acquiring abilities in order to survive, attract and copulate with mates as much as possible.[78] The masculinization of the brain is not just mediated by testosterone levels at the adult stage, but also testosterone exposure in the womb as a fetus. Higher pre-natal testosterone indicated by a low digit ratio as well as adult testosterone levels increased risk of fouls or aggression among male players in a soccer game.[80] Studies have also found higher pre-natal testosterone or lower digit ratio to be correlated with higher aggression in males.[81][82][83][84][85]
The rise in testosterone levels during competition predicted aggression in males but not in females.[86] Subjects who interacted with hand guns and an experimental game showed rise in testosterone and aggression.[87] Natural selection might have evolved males to be more sensitive to competitive and status challenge situations and that the interacting roles of testosterone are the essential ingredient for aggressive behaviour in these situations.[88] Testosterone produces aggression by activating subcortical areas in the brain, which may also be inhibited or suppressed by social norms or familial situations while still manifesting in diverse intensities and ways through thoughts, anger, verbal aggression, competition, dominance and physical violence.[89] Testosterone mediates attraction to cruel and violent cues in men by promoting extended viewing of violent stimuli.[90] Testosterone specific structural brain characteristic can predict aggressive behaviour in individuals.[91]
Estradiol is known to correlate with aggression in male mice.[92] Moreover, the conversion of testosterone to estradiol regulates male aggression in sparrows during breeding season.[93] Rats who were given anabolic steroids that increase testosterone were also more physically aggressive to provocation as a result of "threat sensitivity".[94]
Brain[edit]
The brain is also affected by this sexual differentiation;[13] the enzyme aromatase converts testosterone into estradiol that is responsible for masculinization of the brain in male mice. In humans, masculinization of the fetal brain appears, by observation of gender preference in patients with congenital diseases of androgen formation or androgen receptor function, to be associated with functional androgen receptors.[95]
There are some differences between a male and female brain (possibly the result of different testosterone levels), one of them being size: the male human brain is, on average, larger.[96] Men were found to have a total myelinated fiber length of 176 000 km at the age of 20, whereas in women the total length was 149 000 km (approx. 15% less).[97]
No immediate short term effects on mood or behavior were found from the administration of supraphysiologic doses of testosterone for 10 weeks on 43 healthy men.[98] A correlation between testosterone and risk tolerance in career choice exists among women.[64][99]
Attention, memory, and spatial ability are key cognitive functions affected by testosterone in humans. Preliminary evidence suggests that low testosterone levels may be a risk factor for cognitive decline and possibly for dementia of the Alzheimer's type,[100][101][102][103] a key argument in life extension medicine for the use of testosterone in anti-aging therapies. Much of the literature, however, suggests a curvilinear or even quadratic relationship between spatial performance and circulating testosterone,[104] where both hypo- and hypersecretion (deficient- and excessive-secretion) of circulating androgens have negative effects on cognition.
Medical use[edit]
Main article: Testosterone (medication)
Testosterone is used as a medication for the treatment of males with too little or no natural testosterone production, certain forms of breast cancer,[10] and gender dysphoria in transgender men. This is known as hormone replacement therapy (HRT) or testosterone replacement therapy (TRT), which maintains serum testosterone levels in the normal range. Decline of testosterone production with age has led to interest in androgen replacement therapy.[105] It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful.[106]
Testosterone is included in the World Health Organization's list of essential medicines, which are the most important medications needed in a basic health system.[107] It is available as a generic medication.[10] The price depends on the form of testosterone used.[108] It can be administered as a cream or transdermal patch that is applied to the skin, by injection into a muscle, as a tablet that is placed in the cheek, or by ingestion.[10]
Common side effects from testosterone medication include acne, swelling, and breast enlargement in males.[10] Serious side effects may include liver toxicity, heart disease, and behavioral changes.[10] Women and children who are exposed may develop virilization.[10] It is recommended that individuals with prostate cancer not use the medication.[10] It can cause harm if used during pregnancy or breastfeeding.[10]
Biological activity[edit]
Steroid hormone activity[edit]
The effects of testosterone in humans and other vertebrates occur by way of multiple mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors.[109][110] Androgens such as testosterone have also been found to bind to and activate membrane androgen receptors.[111][112][113]
Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than testosterone, so that its androgenic potency is about 5 times that of T.[114] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Androgen receptors occur in many different vertebrate body system tissues, and both males and females respond similarly to similar levels. Greatly differing amounts of testosterone prenatally, at puberty, and throughout life account for a share of biological differences between males and females.
The bones and the brain are two important tissues in humans where the primary effect of testosterone is by way of aromatization to estradiol. In the bones, estradiol accelerates ossification of cartilage into bone, leading to closure of the epiphyses and conclusion of growth. In the central nervous system, testosterone is aromatized to estradiol. Estradiol rather than testosterone serves as the most important feedback signal to the hypothalamus (especially affecting LH secretion).[115] In many mammals, prenatal or perinatal "masculinization" of the sexually dimorphic areas of the brain by estradiol derived from testosterone programs later male sexual behavior.[116]
Neurosteroid activity[edit]
Testosterone, via its active metabolite 3α-androstanediol, is a potent positive allosteric modulator of the GABAA receptor.[117]
Testosterone has been found to act as an antagonist of the TrkA and p75NTR, receptors for the neurotrophin nerve growth factor (NGF), with high affinity (around 5 nM).[118][119][120] In contrast to testosterone, DHEA and DHEA sulfate have been found to act as high-affinity agonists of these receptors.[118][119][120]
Testosterone is an antagonist of the sigma σ1 receptor (Ki = 1,014 or 201 nM).[121] However, the concentrations of testosterone required for binding the receptor are far above even total circulating concentrations of testosterone in adult males (which range between 10 and 35 nM).[122]
Biochemistry[edit]
Human steroidogenesis, showing testosterone near bottom.[123]
Biosynthesis[edit]
Like other steroid hormones, testosterone is derived from cholesterol (see figure).[124] The first step in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to give pregnenolone. In the next step, two additional carbon atoms are removed by the CYP17A1 (17α-hydroxylase/17,20-lyase) enzyme in the endoplasmic reticulum to yield a variety of C19 steroids.[125] In addition, the 3β-hydroxyl group is oxidized by 3β-hydroxysteroid dehydrogenase to produce androstenedione. In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17β-hydroxysteroid dehydrogenase to yield testosterone.
The largest amounts of testosterone (>95%) are produced by the testes in men,[2] while the adrenal glands account for most of the remainder. Testosterone is also synthesized in far smaller total quantities in women by the adrenal glands, thecal cells of the ovaries, and, during pregnancy, by the placenta.[126] In the testes, testosterone is produced by the Leydig cells.[127] The male generative glands also contain Sertoli cells, which require testosterone for spermatogenesis. Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein, sex hormone-binding globulin (SHBG).
Regulation[edit]
Hypothalamic–pituitary–testicular axis
In males, testosterone is synthesized primarily in Leydig cells. The number of Leydig cells in turn is regulated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition, the amount of testosterone produced by existing Leydig cells is under the control of LH, which regulates the expression of 17β-hydroxysteroid dehydrogenase.[128]
The amount of testosterone synthesized is regulated by the hypothalamic–pituitary–testicular axis (see figure to the right).[129] When testosterone levels are low, gonadotropin-releasing hormone (GnRH) is released by the hypothalamus, which in turn stimulates the pituitary gland to release FSH and LH. These latter two hormones stimulate the testis to synthesize testosterone. Finally, increasing levels of testosterone through a negative feedback loop act on the hypothalamus and pituitary to inhibit the release of GnRH and FSH/LH, respectively.
Factors affecting testosterone levels may include:
Age: Testosterone levels gradually reduce as men age.[130][131] This effect is sometimes referred to as andropause or late-onset hypogonadism.[132]
Exercise: Resistance training increases testosterone levels,[133] however, in older men, that increase can be avoided by protein ingestion.[134] Endurance training in men may lead to lower testosterone levels.[135]
Nutrients: Vitamin A deficiency may lead to sub-optimal plasma testosterone levels.[136] The secosteroid vitamin D in levels of 400–1000 IU/d (10–25 µg/d) raises testosterone levels.[137] Zinc deficiency lowers testosterone levels[138] but over-supplementation has no effect on serum testosterone.[139]
Weight loss: Reduction in weight may result in an increase in testosterone levels. Fat cells synthesize the enzyme aromatase, which converts testosterone, the male sex hormone, into estradiol, the female sex hormone.[140] However no clear association between body mass index and testosterone levels has been found.[141]
Miscellaneous: Sleep: (REM sleep) increases nocturnal testosterone levels.[142] Behavior: Dominance challenges can, in some cases, stimulate increased testosterone release in men.[143] Drugs: Natural or man-made antiandrogens including spearmint tea reduce testosterone levels.[144][145][146] Licorice can decrease the production of testosterone and this effect is greater in females.[147]
Distribution[edit]
The plasma protein binding of testosterone is 98.0 to 98.5%, with 1.5 to 2.0% free or unbound.[148] It is bound 65% to sex hormone-binding globulin (SHBG) and 33% bound weakly to albumin.[149]
Plasma protein binding of testosterone and dihydrotestosterone show
Metabolism[edit]
vte Testosterone metabolism in humans
Testosterone structures
The image above contains clickable linksTestosterone metabolism in humans. Conjugation (sulfation and glucuronidation) occurs both with testosterone and with all of the other steroids that have one or more available hydroxyl (-OH) groups in this diagram.
Both testosterone and 5α-DHT are metabolized mainly in the liver.[1][151] Approximately 50% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases, respectively.[1] An additional 40% of testosterone is metabolized in equal proportions into the 17-ketosteroids androsterone and etiocholanolone via the combined actions of 5α- and 5β-reductases, 3α-hydroxysteroid dehydrogenase, and 17β-HSD, in that order.[1][151][152] Androsterone and etiocholanolone are then glucuronidated and to a lesser extent sulfated similarly to testosterone.[1][151] The conjugates of testosterone and its hepatic metabolites are released from the liver into circulation and excreted in the urine and bile.[1][151][152] Only a small fraction (2%) of testosterone is excreted unchanged in the urine.[151]
In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5α-reductase and 5β-reductase into 5α-DHT and the inactive 5β-DHT, respectively.[1][151] Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.[1][151] Subsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion.[1][151] 3β-Androstanediol and 3β-etiocholanediol can also be formed in this pathway when 5α-DHT and 5β-DHT are acted upon by 3β-HSD instead of 3α-HSD, respectively, and they can then be transformed into epiandrosterone and epietiocholanolone, respectively.[153][154] A small portion of approximately 3% of testosterone is reversibly converted in the liver into androstenedione by 17β-HSD.[152]
In addition to conjugation and the 17-ketosteroid pathway, testosterone can also be hydroxylated and oxidized in the liver by cytochrome P450 enzymes, including CYP3A4, CYP3A5, CYP2C9, CYP2C19, and CYP2D6.[155] 6β-Hydroxylation and to a lesser extent 16β-hydroxylation are the major transformations.[155] The 6β-hydroxylation of testosterone is catalyzed mainly by CYP3A4 and to a lesser extent CYP3A5 and is responsible for 75 to 80% of cytochrome P450-mediated testosterone metabolism.[155] In addition to 6β- and 16β-hydroxytestosterone, 1β-, 2α/β-, 11β-, and 15β-hydroxytestosterone are also formed as minor metabolites.[155][156] Certain cytochrome P450 enzymes such as CYP2C9 and CYP2C19 can also oxidize testosterone at the C17 position to form androstenedione.[155]
Two of the immediate metabolites of testosterone, 5α-DHT and estradiol, are biologically important and can be formed both in the liver and in extrahepatic tissues.[151] Approximately 5 to 7% of testosterone is converted by 5α-reductase into 5α-DHT, with circulating levels of 5α-DHT about 10% of those of testosterone, and approximately 0.3% of testosterone is converted into estradiol by aromatase.[2][151][157][158] 5α-Reductase is highly expressed in the male reproductive organs (including the prostate gland, seminal vesicles, and epididymides),[159] skin, hair follicles, and brain[160] and aromatase is highly expressed in adipose tissue, bone, and the brain.[161][162] As much as 90% of testosterone is converted into 5α-DHT in so-called androgenic tissues with high 5α-reductase expression,[152] and due to the several-fold greater potency of 5α-DHT as an AR agonist relative to testosterone,[163] it has been estimated that the effects of testosterone are potentiated 2- to 3-fold in such tissues.[164]
Levels[edit]
Total levels of testosterone in the body are 264 to 916 ng/dL in men age 19 to 39 years,[165] while mean testosterone levels in adult men have been reported as 630 ng/dL.[166] Levels of testosterone in men decline with age.[165] In women, mean levels of total testosterone have been reported to be 32.6 ng/dL.[167][168] In women with hyperandrogenism, mean levels of total testosterone have been reported to be 62.1 ng/dL.[167][168]
Testosterone levels in males and females show
Total testosterone levels in males throughout life show
Reference ranges for blood tests, showing adult male testosterone levels in light blue at center-left.
Measurement[edit]
Testosterone’s bioavailable concentration is commonly determined using the Vermeulen calculation or more precisely using the modified Vermeulen method,[174][175] which considers the dimeric form of sex-hormone-binding-globulin.[176]
Both methods use chemical equilibrium to derive the concentration of bioavailable testosterone: in circulation testosterone has two major binding partners, albumin (weakly bound) and sex-hormone-binding-globulin (strongly bound). These methods are described in detail in the accompanying figure.
Dimeric sex-hormone-binding-globulin with its testosterone ligands
Two methods for determining concentration of bioavailable testosterone.
History[edit]
A testicular action was linked to circulating blood fractions – now understood to be a family of androgenic hormones – in the early work on castration and testicular transplantation in fowl by Arnold Adolph Berthold (1803–1861).[177] Research on the action of testosterone received a brief boost in 1889, when the Harvard professor Charles-Édouard Brown-Séquard (1817–1894), then in Paris, self-injected subcutaneously a "rejuvenating elixir" consisting of an extract of dog and guinea pig testicle. He reported in The Lancet that his vigor and feeling of well-being were markedly restored but the effects were transient,[178] and Brown-Séquard's hopes for the compound were dashed. Suffering the ridicule of his colleagues, he abandoned his work on the mechanisms and effects of androgens in human beings.
In 1927, the University of Chicago's Professor of Physiologic Chemistry, Fred C. Koch, established easy access to a large source of bovine testicles — the Chicago stockyards — and recruited students willing to endure the tedious work of extracting their isolates. In that year, Koch and his student, Lemuel McGee, derived 20 mg of a substance from a supply of 40 pounds of bovine testicles that, when administered to castrated roosters, pigs and rats, remasculinized them.[179] The group of Ernst Laqueur at the University of Amsterdam purified testosterone from bovine testicles in a similar manner in 1934, but isolation of the hormone from animal tissues in amounts permitting serious study in humans was not feasible until three European pharmaceutical giants—Schering (Berlin, Germany), Organon (Oss, Netherlands) and Ciba (Basel, Switzerland)—began full-scale steroid research and development programs in the 1930s.
Nobel Prize winner, Leopold Ruzicka of Ciba, a pharmaceutical industry giant that synthesized testosterone.
The Organon group in the Netherlands were the first to isolate the hormone, identified in a May 1935 paper "On Crystalline Male Hormone from Testicles (Testosterone)".[180] They named the hormone testosterone, from the stems of testicle and sterol, and the suffix of ketone. The structure was worked out by Schering's Adolf Butenandt, at the Chemisches Institut of Technical University in Gdańsk.[181][182]
The chemical synthesis of testosterone from cholesterol was achieved in August that year by Butenandt and Hanisch.[183] Only a week later, the Ciba group in Zurich, Leopold Ruzicka (1887–1976) and A. Wettstein, published their synthesis of testosterone.[184] These independent partial syntheses of testosterone from a cholesterol base earned both Butenandt and Ruzicka the joint 1939 Nobel Prize in Chemistry.[182][185] Testosterone was identified as 17β-hydroxyandrost-4-en-3-one (C19H28O2), a solid polycyclic alcohol with a hydroxyl group at the 17th carbon atom. This also made it obvious that additional modifications on the synthesized testosterone could be made, i.e., esterification and alkylation.
The partial synthesis in the 1930s of abundant, potent testosterone esters permitted the characterization of the hormone's effects, so that Kochakian and Murlin (1936) were able to show that testosterone raised nitrogen retention (a mechanism central to anabolism) in the dog, after which Allan Kenyon's group[186] was able to demonstrate both anabolic and androgenic effects of testosterone propionate in eunuchoidal men, boys, and women. The period of the early 1930s to the 1950s has been called "The Golden Age of Steroid Chemistry",[187] and work during this period progressed quickly. Research in this golden age proved that this newly synthesized compound—testosterone—or rather family of compounds (for many derivatives were developed from 1940 to 1960), was a potent multiplier of muscle, strength, and well-being.[188]
Other animals[edit]
Testosterone is observed in most vertebrates. Testosterone and the classical nuclear androgen receptor first appeared in gnathostomes (jawed vertebrates).[189] Agnathans (jawless vertebrates) such as lampreys do not produce testosterone but instead use androstenedione as a male sex hormone.[190] Fish make a slightly different form called 11-ketotestosterone.[191] Its counterpart in insects is ecdysone.[192] The presence of these ubiquitous steroids in a wide range of animals suggest that sex hormones have an ancient evolutionary history.[193]
Der Mercedes R107 ist ein zweisitziger Roadster mit auf Wunsch lieferbaren hinteren Notsitzen. Das Schwestermodell Mercedes C107 verfügt gegenüber dem Roadster über einen verlängerten Radstand und ist ein fünfsitziges Coupé mit vollwertigen hinteren Sitzen. Die Wagen gehören zur SL-Baureihe von Mercedes-Benz.
Die SL-Baureihe 107, die 1971 als Nachfolger der sogenannten Pagoden-SL (Baureihe W113) debütierte, begründete mit den Breitband H4-Scheinwerfern und den großen geriffelten Rückleuchten eine neue Designlinie bei Mercedes-Benz. Eine leichte Keilform deutete auf eine verbesserte Aerodynamik hin. Verantwortlicher Designer dieser Serie war erneut Friedrich Geiger, der bereits für die zeitlosen Schöpfungen des 300 SL (einschließlich Roadster) und des vom W111 abgeleiteten Coupés verantwortlich zeichnete. [1]
Mit den Typen 450 SLC und 450 SLC 5.0 bzw. 500 SLC nahm Daimler-Benz Ende der siebziger Jahre an großen Rallyes wie der 30.000 km langen Vuelta à la America del Sud (1977), der Safari-Rallye (1979) und der Bandama-Rallye (1979/1980) teil.
Mittlerweile befindet sich der älteste noch erhaltene R107, ein 350 SL mit der Chassis-Nummer 107043-12-000008 und der Motor-Nummer 116982-12-000001, in der Hand eines Arztes aus Erlangen. Der Wagen ist sandbeigemetallic und wurde am 21. April 1971 in Italien zum ersten Mal zugelassen.
(Wikipedia)
---
The Mercedes-Benz R107 automobiles were produced from 1971 through 1989, being the longest single series ever produced by the firm, besides the G-Class. They were sold under the SL-Class and SLC-Class model names. The R107 replaced the W113 SL-Class in 1972 and was replaced by the R129 SL-Class in 1989.
The R107 took the chassis components of the mid size Mercedes-Benz W114 model and mated them to the larger engines from the S-Class. The W 107 chassis is also referred to as "R 107" for "Reihe" (series). The series comprised SL and SLC models.
The SL variant was a 2-seat convertible/roadster with standard soft top and hardtop. The SLC (technically C107) derivative was a 2 door hardtop coupe, with usable rear seats and in effect an SL stretched 10 inches (254 mm) with a fixed roof. Although some may air this car as an 'SL coupe'- though technically it might be, but in the real world it was an S-class coupe (modern day CL), replacing the former saloon-based 280/300SE coupé in Mercedes` lineup. The SLC was replaced earlier than the SL, in 1981, with a much larger model, the 380SEC. It was aimed at the same market as more exotic machines like the Jaguar E-Type and Citroën SM.
The 107 chassis had the longest run of any Mercedes chassis, 18 years from 1971 to 1989. Some 237,000 107 chassis SL's were built. About two thirds were sold in the US. These 107 cars are larger, heavier and more costly than the previous generation W113 SL cars.
Volume production of the first R107 car, the 350 SL, started in April, 1971 alongside the last of the W 113 cars; the 350 SLC followed in October. Early North American cars wore the name 350 SL, but had a larger 4.5L V8 (and were renamed 450 SL/SLC for model year 1973); the big V8 became available on other markets with the official introduction of the 450 SL/SLC on non-North American markets in March, 1973.
From July, 1974 both SL and SLC could also be ordered with a fuel-injected 2.8L straight-6 as 280 SL and SLC.
In September, 1977 the 450 SLC 5.0 joined the line. This was a special version of the big coupé featuring a bored five-liter version of the 4.5L V8, some light alloy body panels and a black plastic rear spoiler.
The 350, 450 and 450 SLC 5.0 models (like the 350 and 450 SL) were discontinued in 1980 with the introduction of the 380 and 500 SLC in March, 1980. At the same time, the cars received a very mild make-over; the 3-speed automatic was replaced by a four-speed unit, the 280 models came with a standard 5-speed (formerly a 4-speed) manual and all five-liter cars gained a black rear spoiler lip.
The 280, 380 and 500SLC were discontinued in 1981 with the introduction of the 126 series 380 and 500SEC coupes. A total of 62,888 SLCs had been manufactured over a ten year period of which just 1,636 were the 450SLC-5.0 and 1,133 were the 500SLC. Both these models are sought by collectors today. The SLC remains the only fixed roof Mercedes-Benz coupe based on a roadster rather than a sedan. Even today, an SLC in good mechanical condition still gives a mix of good performance, superb handling, comfort and safety, making it is easy to realise why they were a successful rally car.
Following the discontinuation of the SLC in September, 1981, the 107 series continued initially as the 280, 380 and 500SL. At this time, the V8 engines were re-tuned for greater efficiency, lost a few hp and consumed less fuel, helped by substantially numerically shorter axle ratios (that went from 3.27:1 to 2.47:1 for the 380 SL and from 2.72:1 to 2.27:1 for the 500 SL). From September, 1985 the 280SL was replaced by a new 300 SL, and the 380 SL by a 420 SL; the 500 SL continued and a 560SL was introduced for certain extra-European markets, most notably the USA. The final R107 SL was built on August 4, 1989. This eighteen-year run makes the 107 series the longest running series produced by Daimler-Benz.
The last 107 made, a 1989 500SL painted Astral Silver, resides in the Mercedes-Benz museum in Stuttgart, Germany. The W107 series today is prized by classic car collectors; almost all usable examples are worth £5000+ apiece, with the highest-range models sometimes worth £10,000 or more.
(Wikipedia)
This series of 4 photos show basically how to fry a turkey. This one is the raw turkey injected with butter and cajun seasoning.
Bonhams , les grandes marques du monde au Grand Palais 2019
Châssis N° 30837S111365
Moteur N° 3111365 F0305RF
•V8 culbuté à soupapes en tête, 327 cid (5 358 cm3)
•Injection mécanique Rochester
•arbre à cames à culbuteurs
•Rare et recherché modèle « Fuelie »
•360 ch à 6 000 tr/min
•Transmission manuelle à 4 rapports
•Suspension indépendante à ressorts hélicoïdaux
•Suspension arrière indépendante à ressort à lames transversal
•Freins à tambour aux quatre roues
Le directeur du style GM, Bill Mitchell, avait engagé Peter Brock et Larry Shinoda pour l'habiller d'une carrosserie Sting Ray spécifique et immédiatement reconnaissable. Avec une ceinture de caisse profondément marquée sous les ailes joliment courbées, elle avait des phares escamotables actionnés électriquement qui préservait ses qualités aérodynamiques.
doté du moteur à culbuteurs L84 327/360 ch, de la transmission manuelle à 4 rapports M20, des roues en alliage à blocage central, d'une radio AM à chercheur de fréquence et du différentiel Posi-Traction 3,73:1.
Le bloc moteur est estampillé des numéros de châssis et de moteur conformes à la configuration du 327/360 ch à injection mécanique Rochester alimentée en air par un collecteur d'admission Winters « snowflake » (un flocon est gravé dans la fonte).
Malgré un surcoût de 430,40 $, les clients de Corvette 1963 achetèrent 2 610 L84, soit 12,1% de la production totale de la Corvette 1963, en principe équipée de la transmission manuelle à 4 rapports facturée, elle, 180,30 $.
A Leopard 2A4 tank from Lord Strathcona’s Horse (Royal Canadians) drives on a black track during EXERCISE MAPLE RESOLVE 21 in the 3rd Canadian Division Support Base Garrison Wainwright Training Area, Alberta on May 6, 2021.
Photo By: Sailor First Class Camden Scott,
Directorate of Army Public Affairs
20210506LFC0010D47
From May 1 to 11, 2021, about 2500 Canadian Armed Forces members are participating in Exercise MAPLE RESOLVE 21 in Wainwright, Alberta. As the premier annual Canadian Army field training event, Ex MAPLE RESOLVE tests soldier skills and abilities within a realistic, complex, and challenging combat environment.
Du 1er au 11 mai 2021, environ 2 500 membres des Forces armées canadiennes participent à l'exercice MAPLE RESOLVE 21 à Wainwright, en Alberta. En tant que principal événement d'entraînement annuel sur le terrain de l'Armée canadienne, l'exercice MAPLE RESOLVE teste les capacités des soldats dans un environnement de combat réaliste, complexe et stimulant.
ma79lt topic loool ,,
ALL BY : ME
[ without edit bs el nickname oOo el border]
Hope you like it =)
* seen on EXPLORE
Clio started injecting her hormones 3 months ago... But never had an injection as bloody as this one!
After doing this twice in a row, she later started moving the injection site slightly to the outside of the thigh muscle. This put an end to the blood. Nowadays she injects in the butt, anyway.
(1.0" needle for intramuscular thigh injection. Works VERY well, levels-wise, even if they recommend a 1.5" needle for this situation.)
Transition Progress at this point: On hormones since 8/1 (7.5 months); injections since 12/22 (3 months) [18 so far]. Full-time female since 9/15 (6.5 months). Publicly out as trans since 10/11 (5.5 months). Legally female since 12/21 (3 months). 4 transgender group speech therapy classes taken at GW Speech Clinic (since 2/22). Plastic surgery consults continuing. Have seen endo/primary therapist 6X, and 4 other therapists 10X. Weight down to 144lbs (53 down from 197). Hair removal includes 34 electrolysis treatments totaling 26hours; 30 laser hair removal sessions (51 area treatments: 16/15/13/12/8 mouth/goatee/face/neck/armpits, 7 legs/chest, 6 ears/Brazilian); and bi-weekly at-home IPL on arms since 6/17 (9 months). Latisse for eyelash lengthening since 4/17 (11 months). 2 dental implants, Zoom teeth whitening, pierced ears, dyed/layered hair, hypertrophic scars on arms removed. Female wardrobe replacement up to more than 700 items. Total transition expenditures now over $17,800 at this point.
Clio.
injecting estrogen.
bandage, bandaid, blood, hormones, leg, needle, prep pad, syringe, thigh.
upstairs, Clio and Carolyn's house, Alexandria, Virginia.
March 27, 2018.
... Read my blog at clintjcl at wordpress dot com
... Read Carolyn's blog at CarolynCASL at wordpress dot com
A Leopard 2A4 tank from Lord Strathcona’s Horse (Royal Canadians) drives across a road during EXERCISE MAPLE RESOLVE 21 in the 3rd Canadian Division Support Base Garrison Wainwright Training Area, Alberta on May 6, 2021.
Photo By: Sailor First Class Camden Scott,
Directorate of Army Public Affairs
20210506LFC0010D43
From May 1 to 11, 2021, about 2500 Canadian Armed Forces members are participating in Exercise MAPLE RESOLVE 21 in Wainwright, Alberta. As the premier annual Canadian Army field training event, Ex MAPLE RESOLVE tests soldier skills and abilities within a realistic, complex, and challenging combat environment.
Du 1er au 11 mai 2021, environ 2 500 membres des Forces armées canadiennes participent à l'exercice MAPLE RESOLVE 21 à Wainwright, en Alberta. En tant que principal événement d'entraînement annuel sur le terrain de l'Armée canadienne, l'exercice MAPLE RESOLVE teste les capacités des soldats dans un environnement de combat réaliste, complexe et stimulant.
A Leopard 2A4 tank from Lord Strathcona’s Horse (Royal Canadians) drives on a black track during EXERCISE MAPLE RESOLVE 21 in the 3rd Canadian Division Support Base Garrison Wainwright Training Area, Alberta on May 6, 2021.
Photo By: Sailor First Class Camden Scott,
Directorate of Army Public Affairs
20210506LFC0010D46
From May 1 to 11, 2021, about 2500 Canadian Armed Forces members are participating in Exercise MAPLE RESOLVE 21 in Wainwright, Alberta. As the premier annual Canadian Army field training event, Ex MAPLE RESOLVE tests soldier skills and abilities within a realistic, complex, and challenging combat environment.
Du 1er au 11 mai 2021, environ 2 500 membres des Forces armées canadiennes participent à l'exercice MAPLE RESOLVE 21 à Wainwright, en Alberta. En tant que principal événement d'entraînement annuel sur le terrain de l'Armée canadienne, l'exercice MAPLE RESOLVE teste les capacités des soldats dans un environnement de combat réaliste, complexe et stimulant.