The National Ignition Facility's target chamber is ringed with diagnostic instruments, including detectors, oscilloscopes, interferometers and streak cameras, to measure the system's performance and record experimental results. Pictured is the DANTE soft X-ray power diagnostic.

18/01/2022. London, United Kingdom. Boris Johnson-Finchley Memorial Hospital Community Diagnostic. The Prime Minister Boris Johnson visits Finchley Memorial Hospital Community Diagnostic during Covid-19. Picture by Andrew Parsons / No 10 Downing Street

"alors vous voyez les diagnostics possibles pour votre pied c'est comme quand on voit de la fumée sortir d'une maison...y'a plein de causes possibles...peut-être un rôti en train de griller, peut-être un feu de cheminée, peut-être le début d'un incendie qui va s'étendre et détruire la terre entière...on ne peut pas savoir...alors prenons les éléments que nous avons...de la fumée...pas inquiétante pour l'instant...alors ne nous alarmons pas et surveillons..."

:(

18/01/2022. London, United Kingdom. Boris Johnson-Finchley Memorial Hospital Community Diagnostic. The Prime Minister Boris Johnson visits Finchley Memorial Hospital Community Diagnostic during Covid-19. Picture by Andrew Parsons / No 10 Downing Street

© Arnaud Bouissou/MEDDE-MLETR

 

Élément de rendu, DPE (diagnostic de performance énergétique) actuel et DPE prévisible après rénovation conformément aux actions prescrites.

18/01/2022. London, United Kingdom. Boris Johnson-Finchley Memorial Hospital Community Diagnostic. The Prime Minister Boris Johnson visits Finchley Memorial Hospital Community Diagnostic during Covid-19. Picture by Andrew Parsons / No 10 Downing Street

Photographie aérienne par cerf-volant.

 

Kite Aerial Photography.

 

© Octobre 2012, François Levalet www.francoislevalet.fr

Assistance to Kyrgyzstan for diagnostics of COVID-19

 

Ashyralieva Damira, Head of the Laboratory of Molecular Genetic and Diagnostic Research, Department of Disease Prevention and State Sanitary Epidemiological Surveillance, Ministry of Health, Kyrgyzstan and Zhandaeva Aziza, National Liaison Assistant, and Head Specialist of the State Regulation Center on Environment Protection and Ecological Safety, State Agency on Environment Protection and Forestry, Kyrgyzstan with the COVID-19 equipment donated by the IAEA to Kyrgyzstan, received at the Laboratory of Molecular Genetic and Diagnostic Research, Department of Disease Prevention and State Sanitary Epidemiological Surveillance, Ministry of Health, Kyrgyzstan. 10 June 2020.

 

The International Atomic Energy Agency (IAEA) is dispatching equipment to countries around the world to enable them to use a nuclear-derived technique to rapidly detect the coronavirus that causes COVID-19. This emergency assistance is part of the IAEA's response to requests for support from Member States in controlling an increasing number of infections worldwide.

 

Photo Credit: Z. Bakai/State Regulation Center on Environment Protection and Ecological Safety, Kyrgyzstan

The ITER diagnostic residual gas analyzer is under development at ORNL. Photo: US ITER/ORNL

The Silver Star mobile diabetes unit pictured outside the Quotient Diagnostics facility.

20/01/2022. Taunton, United Kingdom. Prime Minister Boris Johnson visits Rutherford Diagnostic Centre. Rutherford Diagnostic. The Prime Minister Boris Johnsons visits Rutherford Diagnostic Centre in Taunton. Picture by Andrew Parsons / No 10 Downing Street

British Medical Ultrasound Society Master Class Meeting at UCD School of Medicine ; 14th November 2015

dx.com/p/pp2000-v23-25-lexia-3-v46-citroen-peugeot-car-di...

- Color: Black

- Material: ABS + copper

- Compatible with Citreon cars including C1, C2, C3, C4, C6, C8 , C-Crosser, Nemo Berlingo,

Jumpy, Jumper, AX, Saxo, BX, etc.

- Diagnostics is performed via OBD-II connector (which is located near steering wheel) or via

manufacturer-specific connector (only older cars, pre-2001)

- Unlike other universal car scanner tools which only read fault codes, this software performs

nearly all the functions like the original dealer diagnostic tool. It contains K-Line

multiplexor, CAN-BUS interfaces and SAE J1850 bus (both PWM and VPW)

- Function:

- Read identification: Displays complete identification of control unit, e.g. part number,

software/hardware version, manufacturer, etc...

- Read fault codes: Displays all stored and pending fault codes with complete description (e.g.

"Rail pressure - too low pressure"). Program supports report printing or copy to clipboard.

- Clear fault codes: This function clears all stored fault codes and other diagnostic

information.

- Auto-scan (complete car scan/test): Detects all ECUs (electronic control units) installed in

car and reads all diagnostic fault codes.

- Measured Values: Program displays live Data like Engine Speed, Battery voltage, Oxygen

Sensor, Coolant Temperature, etc. Values can be displayed in graph, 9 values at once, or full

listing (all measured values). Logging to file is also supported, which allows offline

analysis.

- Actuator test: Actuator test activates particular actuator (e.g. turn on fuel pump,

lock/unlock wheel, lock/unlock doors, cut off fuel, etc.)

- Language: English / German / French / Japanese / Russian / Spanish / Portuguese / Swedish /

Turkish / Dutch / Polish / Italian / Hungary / Greek / Czech

- Hardware required: Intel Celeron/Pentium III 400 MHz, 128 MB RAM, 50MB free HDD space and USB

1.1 port (USB 2.0 recommended)

- OS required: Windows 98 SR2 / 2000 / XP

- Package includes:

- 1 x Main unit with extension OBD2 cable (120cm-cable)

- 1 x Long 9pin to USB cable (120cm)

- 1 x Short 9pin to USB cable (20cm)

- 1 x OBD2 cable (100cm)

- 1 x 16pin to Clip Cable (135cm)

- 1 x Instruction for Installation and Activation DVD for PP2000

Abay Demessie Health Specialist shows the procedures used to test HIV at Abay Health Centre, Bahirdar, Ethiopia. © UNICEF Ethiopia/2013/Sewunet

Diagnostics with orthopan scan

18/01/2022. London, United Kingdom. Boris Johnson-Finchley Memorial Hospital Community Diagnostic. The Prime Minister Boris Johnson visits Finchley Memorial Hospital Community Diagnostic during Covid-19. Picture by Andrew Parsons / No 10 Downing Street

18/01/2022. London, United Kingdom. Boris Johnson-Finchley Memorial Hospital Community Diagnostic. The Prime Minister Boris Johnson visits Finchley Memorial Hospital Community Diagnostic during Covid-19. Picture by Andrew Parsons / No 10 Downing Street

Diagnostic Cardiac Sonography — Echocardiography August 2016

The OMP Repair Manual tells the truth!

data and diagnostics

18/01/2022. London, United Kingdom. Boris Johnson-Finchley Memorial Hospital Community Diagnostic. The Prime Minister Boris Johnson visits Finchley Memorial Hospital Community Diagnostic during Covid-19. Picture by Andrew Parsons / No 10 Downing Street

PS2 HAEVY DUTY can diagnose VOLVO, SCANIA, MAN, IVECO,MERCEDES BENZ,ISUZU,MACK, COMMINS,HINO,FUSO at present, and will add DAF, Renault , ERF,SINOTRUCK,NISSAN UD etc in the near future!

  

PS2 Heavy automobile computer diagnostic tool is a major product which our company developed recently. Our technicians in programming and R&D section play a technical leading role in this business. Most engineers have rich experiences for designing platform and software. Therefore, our custom will feel the outstanding and powerful performance of the product.

As for the design of PS2, our technicians perfectly mix appearances with practicality. With jumbo size, true-color, full touching screen and simple body, customers will operate PS2 more intuitively and easily. The capability of the built-in highly processing chip could reach 400MHZ. Its ability is superior to the common used ARM7 chip. Such excellent performance of the chip and the superior diagnostic module will guarantee the accuracy and real-time function. The demonstration for data stream of PS2 shows its accuracy and rapidity which will enhance the convenience of our guests.

In the compatible aspect of data agreement, PS2 comprehensively supports all protocols and all modes for the OBD II. The built-in CAN BUS chip supports all CAN BUS agreements. The forward-looking design of PS2 meets the need not only for the present but also for the future automobile main-line examination. The drivers of diagnostic module can be updated through the internet. The formidable compatibility reduces the equipped adapter. PS2 is easy to handle and users will experience the unique design from our R&D team.

We also provides wireless communication version of PS2. The servicemen can sits in the office to carry on the functional test. The VAG connector could meet the various requests from customers. All test procedures places on a high-capacity SD card which facilitates the updating procedure. The mulit-language edition will satisfy the demands from our customer around the world.

As a result of massive field test, PS2 becomes a matured and integrated product. Excellence is our motto. We make every effort to develop and to innovate our product which enables PS2 to become an reliable automobile diagnostic equipment. The speedy test, the accuracy and the user-friendly design of SP2 help us to enjoy the support of all customers!

PS2 is a high-tech and professional automobile diagnostic tool. Please follow the instruction to use the product. If you have any problems or questions related to the operation, please contact post-sale Technical service department for further instruction.

  

Power switch: Uses for starting and closing of main engine

USB connection: Uses this connection to carry on the data synchronization with PC.

VGA connection: Uses this connection to link the external monitor (800×600 pixels)

Main test connection: Uses the testing line to carry on the vehicles diagnosis.

power connection: Uses for the exterior power supply

touching pen: Uses in clicking on the touching-screen.

  

4. functions of VCI diagnostic box:

 

The box is bridging the PS2 mainframe and the automobile diagnostic base. It is called lower position machine. This diagnostic box has two connections, the DB15 connection and the OBD II connection. The main testing line connects the PS2 mainframe with the DB15 adapter. The OBDII connection could link with the testing adapter (PS2 with OBDII diagnostic base could directly link with automobile connection base)

Because the blue-teeth communication module is installed in the VCI diagnosis box, the PS2 mainframe could proceed the diagnosis without the main testing line. The on-line diagnosis should be changed to the wireless diagnosis mode on the menu.serial port: Uses in the main body debugging.

SD card slot: uses for SD cardPower switch: Uses for starting and closing of main engine

USB connection: Uses this connection to carry on the data synchronization with PC.

VGA connection: Uses this connection to link the external monitor (800×600 pixels)

Main test connection: Uses the testing line to carry on the vehicles diagnosis.

power connection: Uses for the exterior power supply

touching pen: Uses in clicking on the touching-screen.

  

5. PS2 technical parameters:

operating system: WINCE 5.0 operating platforms

CPU: SAMSUNG 32 bits processors, basic frequency is 400MHZ random memory: SDRAM 64M

programming memory: FLASH 64M

exterior memory: supports SD card slot-in and slot-out

mainframe power supply: DC12V/24V

mainframe power: 25W

printer: Mini high-speed thermal sensitive printer

screen: 8 inches real-color touch-screens, 800×600 with LED back-light

machine composition: mainframe, testing adapter, group of lines, manual and outside box

temperature: -20-50

relative humidity: <90%

mainframe battery: rechargeable battery 3500m/Ah

wireless communication: blue-teeth

overall size: 305.2×215.2×85mm

weight: 10KG

    

www.auto-ecu-tool.com

20/01/2022. Taunton, United Kingdom. Prime Minister Boris Johnson visits Rutherford Diagnostic Centre. Rutherford Diagnostic. The Prime Minister Boris Johnsons visits Rutherford Diagnostic Centre in Taunton. Picture by Andrew Parsons / No 10 Downing Street

Autism spectrum disorder[a] (ASD), or simply autism, is a neurodevelopmental disorder "characterized by persistent deficits in social communication and social interaction across multiple contexts" and "restricted, repetitive patterns of behavior, interests, or activities".[11] Sensory abnormalities are also included in the diagnostic manuals. Common associated traits such as motor coordination impairment are typical of the condition but not required for diagnosis. A formal diagnosis requires that symptoms cause significant impairment in multiple functional domains, in addition to being atypical or excessive for the person's age and sociocultural context.[12][13]

 

Autism is a spectrum disorder, meaning it manifests in various ways, with its severity and support needs varying widely across different autistic people.[12][13][14] For example, some autistic people are nonverbal, while others have proficient spoken language. Furthermore, the spectrum is multi-dimensional and not all dimensions have been identified as of 2024.[15][16]

 

Public health authorities and guideline developers classify autism as a neurodevelopmental disorder,[12][17][13][18][19] but the autism rights movement (and some researchers) disagree with the classification. From the latter point of view, autistic people may be diagnosed with a disability, but that disability may be rooted in the structures of a society rather than the person.[20][21][22] On the contrary, other scientists argue that autism impairs functioning in many ways that are inherent to the disorder itself and unrelated to society.[23][24] The neurodiversity perspective has led to significant controversy among those who are autistic and advocates, practitioners, and charities.[25][26]

 

The precise causes of autism are unknown in most individual cases. Research shows that the disorder is highly heritable and polygenic, and neurobiological risks from the environment are also relevant.[27][28][29] Boys are also significantly far more frequently diagnosed than girls.[30]

 

Autism frequently co-occurs with attention deficit hyperactivity disorder (ADHD), epilepsy, and intellectual disability.[31][32][33] Disagreements persist about what should be part of the diagnosis, whether there are meaningful subtypes or stages of autism,[34] and the significance of autism-associated traits in the wider population.[35][36]

 

The combination of broader criteria, increased awareness, and the potential increase of actual prevalence has led to considerably increased estimates of autism prevalence since the 1990s.[37][38] The WHO estimates about 1 in 100 children had autism between 2012 and 2021, as that was the average estimate in studies during that period, with a trend of increasing prevalence over time.[b][9][10] This increasing prevalence has contributed to the myth perpetuated by anti-vaccine activists that autism is caused by vaccines.[39]

 

There is no known cure for autism, and some advocates dispute the need to find one.[40][41] Interventions such as applied behavior analysis (ABA), speech therapy, and occupational therapy can help these children gain self-care, social, and language skills.[42][43] Guidelines from the Centres for Disease Control (CDC), and European Society for Child & Adolescent Psychiatry endorse the use of ABA on the grounds that it reduces symptoms impairing daily functioning and quality of life,[42][44] but the National Institute for Health and Care Excellence cites a lack of high-quality evidence to support its use.[45] Additionally, some in the autism rights movement oppose its application due to a perception that it emphasises normalisation.[46][47][48] No medication has been shown to reduce ASD's core symptoms,[44] but some can alleviate comorbid issues.[49][50][51]

 

Classification

Spectrum model

Before the DSM-5 (2013) and ICD-11 (2022) diagnostic manuals were adopted, ASD was found under the diagnostic category pervasive developmental disorder. The previous system relied on a set of closely related and overlapping diagnoses such as Asperger syndrome and the syndrome formerly known as Kanner syndrome. This created unclear boundaries between the terms, so for the DSM-5 and ICD-11, a spectrum approach was taken. The new system is also more restrictive, meaning fewer people qualify for diagnosis.[52]

 

The DSM-5 and ICD-11 use different categorization tools to define this spectrum. DSM-5 uses a "level" system, which ranks how in need of support the patient is, level 1 being the mildest and level 3 the severest,[53] while the ICD-11 system has two axes, intellectual impairment and language impairment,[54] as these are seen as the most crucial factors.

 

Autism is currently defined as a highly variable neurodevelopmental disorder[55] that is generally thought to cover a broad and deep spectrum, manifesting very differently from one person to another. Some have high support needs, may be nonspeaking, and experience developmental delays; this is more likely with other co-existing diagnoses. Others have relatively low support needs; they may have more typical speech-language and intellectual skills but atypical social/conversation skills, narrowly focused interests, and wordy, pedantic communication.[56] They may still require significant support in some areas of their lives. The spectrum model should not be understood as a continuum running from mild to severe, but instead means that autism can present very differently in each person.[57] How it presents in a person can depend on context, and may vary over time.[58]

 

While the DSM and ICD greatly influence each other, there are also differences. For example, Rett syndrome was included in ASD in the DSM-5, but in the ICD-11 it was excluded and placed in the chapter on Developmental Anomalies. The ICD and the DSM change over time, and there has been collaborative work toward a convergence of the two since 1980 (when DSM-III was published and ICD-9 was current), including more rigorous biological assessment—in place of historical experience—and a simplification of the classification system.[59][60][61][62]

 

As of 2023, empirical and theoretical research is leading to a growing consensus among researchers that the established ASD criteria are ineffective descriptors of autism as a whole, and that alternative research approaches must be encouraged, such as going back to autism prototypes, exploring new causal models of autism, or developing transdiagnostic endophenotypes.[63] Proposed alternatives to the current disorder-focused spectrum model deconstruct autism into at least two separate phenomena: (1) a non-pathological spectrum of behavioral traits in the population,[64][65] and (2) the neuropathological burden of rare genetic mutations and environmental risk factors potentially leading to neurodevelopmental and psychological disorders,[64][65] (3) governed by an individual's cognitive ability to compensate.[64]

 

ICD

The World Health Organization's International Classification of Diseases (11th revision), ICD-11, was released in June 2018 and came into full effect as of January 2022.[66][59] It describes ASD as follows:[67]

 

Autism spectrum disorder is characterised by persistent deficits in the ability to initiate and to sustain reciprocal social interaction and social communication, and by a range of restricted, repetitive, and inflexible patterns of behaviour, interests or activities that are clearly atypical or excessive for the individual's age and sociocultural context. The onset of the disorder occurs during the developmental period, typically in early childhood, but symptoms may not become fully manifest until later, when social demands exceed limited capacities. Deficits are sufficiently severe to cause impairment in personal, family, social, educational, occupational or other important areas of functioning and are usually a pervasive feature of the individual's functioning observable in all settings, although they may vary according to social, educational, or other context. Individuals along the spectrum exhibit a full range of intellectual functioning and language abilities.

 

— ICD-11, chapter 6, section A02

ICD-11 was produced by professionals from 55 countries out of the 90 involved and is the most widely used reference worldwide.

 

DSM

The American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), released in 2022, is the current version of the DSM. It is the predominant mental health diagnostic system used in the United States and Canada, and is often used in Anglophone countries.

 

Its fifth edition, DSM-5, released in May 2013, was the first to define ASD as a single diagnosis,[68] which is still the case in the DSM-5-TR.[69] ASD encompasses previous diagnoses, including the four traditional diagnoses of autism—classic autism, Asperger syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (PDD-NOS)—and the range of diagnoses that included the word "autism".[70] Rather than distinguishing among these diagnoses, the DSM-5 and DSM-5-TR adopt a dimensional approach with one diagnostic category for disorders that fall under the autism spectrum umbrella. Within that category, the DSM-5 and the DSM include a framework that differentiates each person by dimensions of symptom severity, as well as by associated features (i.e., the presence of other disorders or factors that likely contribute to the symptoms, other neurodevelopmental or mental disorders, intellectual disability, or language impairment).[69] The symptom domains are (a) social communication and (b) restricted, repetitive behaviors, and there is the option of specifying a separate severity—the negative effect of the symptoms on the person—for each domain, rather than just overall severity.[71] Before the DSM-5, the DSM separated social deficits and communication deficits into two domains.[72] Further, the DSM-5 changed to an onset age in the early developmental period, with a note that symptoms may manifest later when social demands exceed capabilities, rather than the previous, more restricted three years of age.[73] These changes remain in the DSM-5-TR.[69]

 

Signs and symptoms

See also: Outline of autism

Pre-diagnosis

For many autistic people, characteristics first appear during infancy or childhood and follow a steady course without remission (different developmental timelines are described in more detail below).[74] Autistic people may be severely impaired in some respects but average, or even superior, in others.[75][76][77]

 

Clinicians consider assessment for ASD when a patient shows:

 

Regular difficulties in social interaction or communication

Restricted or repetitive behaviors (often called "stimming")

Resistance to changes or restricted interests

These features are typically assessed with the following, when appropriate:

 

Problems in obtaining or sustaining employment or education

Difficulties in initiating or sustaining social relationships

Connections with mental health or learning disability services

A history of neurodevelopmental conditions (including learning disabilities and ADHD) or mental health conditions[78][79]

There are many signs associated with autism; the presentation varies widely. Common signs and symptoms include:[80][81]

 

Abnormalities in eye contact

Little or no babbling as an infant

Not showing interest in indicated objects

Delayed language skills (e.g., having a smaller vocabulary than peers or difficulty expressing themselves in words)

Reduced interest in other children or caretakers, possibly with more interest in objects

Difficulty playing reciprocal games (e.g., peek-a-boo)

Hyper- or hypo-sensitivity to or unusual response to the smell, texture, sound, taste, or appearance of things

Resistance to changes in routine

Repetitive, limited, or otherwise unusual usage of toys (e.g., lining up toys)

Repetition of words or phrases, including echolalia

Repetitive motions or movements, including stimming

Broader autism phenotype

The broader autism phenotype describes people who may not have ASD but do have autistic traits, such as abnormalities in eye contact and stimming.[82]

  

In 1996, American academic Temple Grandin published Emergence: Labeled Autistic, describing her life experiences as an autistic person.

Social and communication skills

According to the medical model, autistic people experience social communications impairments. Until 2013, deficits in social function and communication were considered two separate symptom domains.[83] The current social communication domain criteria for autism diagnosis require people to have deficits across three social skills: social-emotional reciprocity, nonverbal communication, and developing and sustaining relationships.[69]

 

A deficit-based view predicts that autistic–autistic interaction would be less effective than autistic–non-autistic interactions or even non-functional.[84] But recent research has found that autistic–autistic interactions are as effective in information transfer as interactions between non-autistics are, and that communication breaks down only between autistics and non-autistics.[84][85] Also contrary to social cognitive deficit interpretations, recent (2019) research recorded similar social cognitive performances in autistic and non-autistic adults, with both of them rating autistic individuals less favorably than non-autistic individuals; however, autistic individuals showed more interest in engaging with autistic people than non-autistic people did, and learning of a person's ASD diagnosis did not influence their interest level.[86]

 

Thus, there has been a recent shift to acknowledge that autistic people may simply respond and behave differently than people without ASD.[87] So far, research has identified two unconventional features by which autistic people create shared understanding (intersubjectivity): "a generous assumption of common ground that, when understood, led to rapid rapport, and, when not understood, resulted in potentially disruptive utterances; and a low demand for coordination that ameliorated many challenges associated with disruptive turns."[85] Autistic interests, and thus conversational topics, seem to be largely driven by an intense interest in specific topics (monotropism).[88][89]

 

Historically, autistic children were said to be delayed in developing a theory of mind, and the empathizing–systemizing theory has argued that while autistic people have compassion (affective empathy) for others with similar presentation of symptoms, they have limited, though not necessarily absent, cognitive empathy.[90] This may present as social naïvety,[91] lower than average intuitive perception of the utility or meaning of body language, social reciprocity,[92] or social expectations, including the habitus, social cues, and some aspects of sarcasm,[93] which to some degree may also be due to comorbid alexithymia.[94] But recent research has increasingly questioned these findings, as the "double empathy problem" theory (2012) argues that there is a lack of mutual understanding and empathy between both non-autistic persons and autistic individuals.[95][96][97][98][99]

 

As communication is bidirectional,[100] research on communication difficulties has since also begun to study non-autistic behavior, with researcher Catherine Crompton writing in 2020 that non-autistic people "struggle to identify autistic mental states, identify autistic facial expressions, overestimate autistic egocentricity, and are less willing to socially interact with autistic people. Thus, although non-autistic people are generally characterised as socially skilled, these skills may not be functional or effectively applied when interacting with autistic people."[84] Any previously observed communication deficits of autistic people may thus have been constructed through a neurotypical bias in autism research, which has come to be scrutinized for "dehumanization, objectification, and stigmatization".[101] Recent research has proposed that autistics' lack of readability and a neurotypical lack of effort to interpret atypical signals may cause a negative interaction loop, increasingly driving both groups apart into two distinct groups with different social interaction styles.[100]

 

Differences in verbal communication begin to be noticeable in childhood, as many autistic children develop language skills at an uneven pace. Verbal communication may be delayed or never developed (nonverbal autism), while reading ability may be present before school age (hyperlexia).[102][103] Reduced joint attention seem to distinguish autistic from non-autistic infants.[104] Infants may show delayed onset of babbling, unusual gestures, diminished responsiveness, and vocal patterns that are not synchronized with the caregiver. In the second and third years, autistic children may have less frequent and less diverse babbling, consonants, words, and word combinations; their gestures are less often integrated with words. Autistic children are less likely to make requests or share experiences and are more likely to simply repeat others' words (echolalia).[105] The CDC estimated in 2015 that around 40% of autistic children do not speak at all.[106] Autistic adults' verbal communication skills largely depend on when and how well speech is acquired during childhood.[102]

 

Autistic people display atypical nonverbal behaviors or show differences in nonverbal communication. They may make infrequent eye contact, even when called by name, or avoid it altogether. This may be due to the high amount of sensory input received when making eye contact.[107] Autistic people often recognize fewer emotions and their meaning from others' facial expressions, and may not respond with facial expressions expected by their non-autistic peers.[108][103] Temple Grandin, an autistic woman involved in autism activism, described her inability to understand neurotypicals' social communication as leaving her feeling "like an anthropologist on Mars".[109] Autistic people struggle to understand the social context and subtext of neurotypical conversational or printed situations, and form different conclusions about the content.[110] Autistic people may not control the volume of their voice in different social settings.[111] At least half of autistic children have atypical prosody.[111]

 

What may look like self-involvement or indifference to non-autistic people stems from autistic differences in recognizing how other people have their own personalities, perspectives, and interests.[110][112] Most published research focuses on the interpersonal relationship difficulties between autistic people and their non-autistic counterparts and how to solve them through teaching neurotypical social skills, but newer research has also evaluated what autistic people want from friendships, such as a sense of belonging and good mental health.[113][114] Children with ASD are more frequently involved in bullying situations than their non-autistic peers, and predominantly experience bullying as victims rather than perpetrators or victim-perpetrators, especially after controlling for comorbid psychopathology.[115] Prioritizing dependability and intimacy in friendships during adolescence, coupled with lowered friendship quantity and quality, often lead to increased loneliness in autistic people.[116] As they progress through life, autistic people observe and form a model of social patterns, and develop coping mechanisms, referred to as "masking",[117][118] which have recently been found to come with psychological costs and a higher increased risk of suicidality.[100]

 

Restricted and repetitive behaviors

Sleeping boy beside a dozen or so toys arranged in a line

A young autistic boy who has arranged his toys in a row

ASD includes a wide variety of characteristics. Some of these include behavioral characteristics, which widely range from slow development of social and learning skills to difficulties creating connections with other people. Autistic people may experience these challenges with forming connections due to anxiety or depression, which they are more likely to experience, and as a result isolate themselves.[119][120]

 

Other behavioral characteristics include abnormal responses to sensations (such as sights, sounds, touch, taste and smell) and problems keeping a consistent speech rhythm. The latter problem influences social skills, leading to potential problems in understanding for interlocutors. Autistic people's behavioral characteristics typically influence development, language, and social competence. Their behavioral characteristics can be observed as perceptual disturbances, disturbances of development rate, relating, speech and language, and motility.[121]

 

The second core symptom of autism spectrum is a pattern of restricted and repetitive behaviors, activities, and interests. In order to be diagnosed with ASD under the DSM-5-TR, a person must have at least two of the following behaviors:[69][122]

  

An autistic boy arranging brads on a cork coaster

Repetitive behaviors – Repetitive behaviors such as rocking, hand flapping, finger flicking, head banging, or repeating phrases or sounds.[123] These behaviors may occur constantly or only when the person gets stressed, anxious, or upset. These behaviors are also known as stimming.

Resistance to change – A strict adherence to routines such as eating certain foods in a specific order or taking the same path to school every day.[123] The person may become distressed if there is a change or disruption to their routine.

Restricted interests – An excessive interest in a particular activity, topic, or hobby, and devoting all their attention to it. For example, young children might completely focus on things that spin and ignore everything else. Older children might try to learn everything about a single topic, such as the weather or sports, and perseverate or talk about it constantly.[123]

Sensory reactivity – An unusual reaction to certain sensory inputs, such as negative reaction to specific sounds or textures, fascination with lights or movements, or apparent indifference to pain or heat.[124]

Autistic people can display many forms of repetitive or restricted behavior, which the Repetitive Behavior Scale-Revised (RBS-R) categorizes as follows.[125]

 

Stereotyped behaviors: Repetitive movements, such as hand flapping, head rolling, or body rocking.

Compulsive behaviors: Time-consuming behaviors intended to reduce anxiety, that a person feels compelled to perform repeatedly or according to rigid rules, such as placing objects in a specific order, checking things, or handwashing.

Sameness: Resistance to change; for example, insisting that the furniture not be moved or refusing to be interrupted.

Ritualistic behavior: Unvarying pattern of daily activities, such as an unchanging menu or a dressing ritual. This is closely associated with sameness and an independent validation has suggested combining the two factors.[125]

Self-injurious behaviors: Behaviors such as eye-poking, skin-picking, hand-biting and head-banging.[104]

Self-injury and suicide

Self-injurious behaviors are relatively common in autistic people, and can include head-banging, self-cutting, self-biting, and hair-pulling.[126] Some of these can result in serious injury or death.[126] Autistic people are about three times as likely as non-autistic people to engage in self-injury.[127]

 

Theories about the cause of self-injurious behavior in children with developmental delay, including autistic children, include:[128]

 

Frequency or continuation of self-injurious behavior can be influenced by environmental factors (e.g., reward in return for halting self-injurious behavior). This theory does not apply to younger children with autism. There is some evidence that frequency of self-injurious behavior can be reduced by removing or modifying environmental factors that reinforce the behavior.[128]: 10–12 

Higher rates of self-injury are noted in socially isolated autistic people. Studies have shown that socialization skills are related factors to self-injurious behavior for autistic people.[129]

Self-injury could be a response to modulate pain perception when chronic pain or other health problems that cause pain are present.[128]: 12–13 

Abnormal basal ganglia connectivity may predispose to self-injurious behavior.[128]: 13 

Risk factors for self-harm and suicidality include circumstances that could affect anyone, such as mental health problems (e.g., anxiety disorder) and social problems (e.g., unemployment and social isolation), plus factors that affect only autistic people, such as actively trying to behave like like a neurotypical person, which is called masking.[130]

 

Rates of suicidality vary significantly depending upon what is being measured.[130] This is partly because questionnaires developed for neurotypical subjects are not always valid for autistic people.[130] As of 2023, the Suicidal Behaviours Questionnaire–Autism Spectrum Conditions (SBQ-ASC) is the only test validated for autistic people.[130] According to some estimates, about a quarter of autistic youth[131] and a third of all autistic people[130][132] have experienced suicidal ideation at some point. Rates of suicidal ideation are the same for people formally diagnosed with autism and people who have typical intelligence and are believed to have autism but have not been diagnosed.[130]

 

Although most people who attempt suicide are not autistic,[130] autistic people are about three times as likely as non-autistic people to make a suicide attempt.[127][133] Less than 10% of autistic youth have attempted suicide,[131] but 15% to 25% autistic adults have.[130][132] The rates of suicide attempts are the same among people formally diagnosed with autism and those who have typical intelligence and are believed to have autism but have not been diagnosed.[130] The suicide risk is lower among cisgender autistic males and autistic people with intellectual disabilities.[130][133] The rate of suicide results in a global excess mortality among autistic people equal to approximately 2% of all suicide deaths each year.[133]

 

Burnout

Main article: Autistic burnout

 

This section should include a summary of Autistic burnout. See Wikipedia:Summary style for information on how to incorporate it into this article's main text. (August 2024)

Studies have supported the common belief that autistic people become exhausted or burnt out in some situations.[134][135][136][137]

  

In 2021, screenwriter and actor Wentworth Miller revealed his autism diagnosis in a now-deleted Instagram post, stating it was "a shock" but "not a surprise".[138]

Other features

Autistic people may have symptoms that do not contribute to the official diagnosis, but that can affect the person or the family.[139]

 

Some autistic people show unusual or notable abilities, ranging from splinter skills (such as the memorization of trivia) to rare talents in mathematics, music, or artistic reproduction, which in exceptional cases are considered a part of the savant syndrome.[140][141][142] One study describes how some autistic people show superior skills in perception and attention relative to the general population.[143] Sensory abnormalities are found in over 90% of autistic people, and are considered core features by some.[144]

More generally, autistic people tend to show a "spiky skills profile", with strong abilities in some areas contrasting with much weaker abilities in others.[145]

Autistic people are less likely to show cognitive or emotional biases, and usually process information more rationally.[146] On the other hand, most autistic people exhibit lower levels of emotional intelligence, the ability to understand nonverbal clues about other people's feelings.[147]

Differences between the previously recognized disorders under the autism spectrum are greater for under-responsivity (for example, walking into things) than for over-responsivity (for example, distress from loud noises) or for sensation seeking (for example, rhythmic movements).[148] An estimated 60–80% of autistic people have motor signs that include poor muscle tone, poor motor planning, and toe walking;[144][149] deficits in motor coordination are pervasive across ASD and are greater in autism proper.[150][151]

Pathological demand avoidance can occur. People with this set of autistic symptoms are more likely to refuse to do what is asked or expected of them, even to activities they enjoy.

Unusual or atypical eating behavior occurs in about three-quarters of children with ASD, to the extent that it was formerly a diagnostic indicator.[139] Selectivity is the most common problem, although eating rituals and food refusal also occur.[152]

Problematic digital media use

See also: Screen time, Internet addiction disorder, and Video game addiction

This section is an excerpt from Digital media use and mental health § Autism.[edit]

In September 2018, the Review Journal of Autism and Developmental Disorders published a systematic review of 47 studies published from 2005 to 2016 that concluded that associations between autism spectrum disorder (ASD) and screen time was inconclusive.[153] In May 2019, the Journal of Developmental and Behavioral Pediatrics published a systematic review of 16 studies that found that children and adolescents with ASD are exposed to more screen time than typically developing peers and that the exposure starts at a younger age.[154] In April 2021, Research in Autism Spectrum Disorders published a systematic review of 12 studies of video game addiction in ASD subjects that found that children, adolescents, and adults with ASD are at greater risk of video game addiction than those without ASD, and that the data from the studies suggested that internal and external factors (sex, attention and oppositional behavior problems, social aspects, access and time spent playing video games, parental rules, and game genre) were significant predictors of video game addiction in ASD subjects.[155] In March 2022, the Review Journal of Autism and Developmental Disorders published a systematic review of 21 studies investigating associations between ASD, problematic internet use, and gaming disorder where the majority of the studies found positive associations between the disorders.[156]

 

In August 2022, the International Journal of Mental Health and Addiction published a review of 15 studies that found that high rates of video game use in boys and young males with ASD was predominantly explained by video game addiction, but also concluded that greater video game use could be a function of ASD restricted interest and that video game addiction and ASD restricted interest could have an interactive relationship.[157] In December 2022, the Review Journal of Autism and Developmental Disorders published a systematic review of 10 studies researching the prevalence of problematic internet use with ASD that found that ASD subjects had more symptoms of problematic internet use than control group subjects, had higher screen time online and an earlier age of first-time use of the internet, and also greater symptoms of depression and ADHD.[158] In July 2023, Cureus published a systematic review of 11 studies that concluded that earlier and longer screen time exposure for children was associated with higher probability of a child "developing" ASD.[159] In December 2023, JAMA Network Open published a meta-analysis of 46 studies comprising 562,131 subjects that concluded that while screen time may be a developmental cause of ASD in childhood, associations between ASD and screen time were not statistically significant when accounting for publication bias.[160]

Possible causes

Main article: Causes of autism

Exactly what causes autism remains unknown.[161][162][163][164] It was long mostly presumed that there is a common cause at the genetic, cognitive, and neural levels for the social and non-social components of ASD's symptoms, described as a triad in the classic autism criteria.[165] But it is increasingly suspected that autism is instead a complex disorder whose core aspects have distinct causes that often cooccur.[165][166] It is unlikely that ASD has a single cause;[166] many risk factors identified in the research literature may contribute to ASD. These include genetics, prenatal and perinatal factors (meaning factors during pregnancy or very early infancy), neuroanatomical abnormalities, and environmental factors. It is possible to identify general factors, but much more difficult to pinpoint specific ones. Given the current state of knowledge, prediction can only be of a global nature and so requires the use of general markers.[clarification needed][167]

 

Biological subgroups

Research into causes has been hampered by the inability to identify biologically meaningful subgroups within the autistic population[168] and by the traditional boundaries between the disciplines of psychiatry, psychology, neurology and pediatrics.[169] Newer technologies such as fMRI and diffusion tensor imaging can help identify biologically relevant phenotypes (observable traits) that can be viewed on brain scans, to help further neurogenetic studies of autism;[170] one example is lowered activity in the fusiform face area of the brain, which is associated with impaired perception of people versus objects.[171] It has been proposed to classify autism using genetics as well as behavior.[172]

 

Syndromic autism and non-syndromic autism

Main article: Syndromic autism

Autism spectrum disorder (ASD) can be classified into two categories: "syndromic autism" and "non-syndromic autism".

 

Syndromic autism refers to cases where ASD is one of the characteristics associated with a broader medical condition or syndrome, representing about 25% of ASD cases. The causes of syndromic autism are often known, and monogenic disorders account for approximately 5% of these cases.

 

Non-syndromic autism, also known as classic or idiopathic autism, represents the majority of cases, and its cause is typically polygenic and unknown.

 

Genetics

Main articles: Heritability of autism and Epigenetics of autism

See also: Missing heritability problem

 

Hundreds of different genes are implicated in susceptibility to developing autism,[173] most of which alter the brain structure in a similar way.

Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether ASD is explained more by rare mutations with major effects, or by rare multi-gene interactions of common genetic variants.[174][175] Complexity arises due to interactions among multiple genes, the environment, and epigenetic factors which do not change DNA sequencing but are heritable and influence gene expression.[176] Many genes have been associated with autism through sequencing the genomes of affected people and their parents.[177] But most of the mutations that increase autism risk have not been identified. Typically, autism cannot be traced to a Mendelian (single-gene) mutation or to a single chromosome abnormality, and none of the genetic syndromes associated with ASD have been shown to selectively cause ASD.[174] Numerous genes have been found, with only small effects attributable to any particular gene.[174] Most loci individually explain less than 1% of cases of autism.[178] As of 2018, it appeared that between 74% and 93% of ASD risk is heritable.[122] After an older child is diagnosed with ASD, 7% to 20% of subsequent children are likely to be as well.[122] If parents have one autistic child, they have a 2% to 8% chance of having a second child who is autistic. If the autistic child is an identical twin, the other will be affected 36% to 95% of the time. A fraternal twin is affected up to 31% of the time.[179] The large number of autistic people with unaffected family members may result from spontaneous structural variation, such as deletions, duplications or inversions in genetic material during meiosis.[180][181] Hence, a substantial fraction of autism cases may be traceable to genetic causes that are highly heritable but not inherited: that is, the mutation that causes the autism is not present in the parental genome.[182]

 

As of 2018, understanding of genetic risk factors had shifted from a focus on a few alleles to an understanding that genetic involvement in ASD is probably diffuse, depending on a large number of variants, some of which are common and have a small effect, and some of which are rare and have a large effect. The most common gene disrupted with large effect rare variants appeared to be CHD8, but less than 0.5% of autistic people have such a mutation. The gene CHD8 encodes the protein chromodomain helicase DNA binding protein 8, which is a chromatin regulator enzyme that is essential during fetal development. CHD8 is an adenosine triphosphate (ATP)–dependent enzyme.[183][184][185] The protein contains an Snf2 helicase domain that is responsible for the hydrolysis of ATP to adenosine diphosphate (ADP).[185] CHD8 encodes a DNA helicase that functions as a repressor of transcription, remodeling chromatin structure by altering the position of nucleosomes. CHD8 negatively regulates Wnt signaling. Wnt signaling is important in the vertebrate early development and morphogenesis. It is believed that CHD8 also recruits the linker histone H1 and causes the repression of β-catenin and p53 target genes.[183] The importance of CHD8 can be observed in studies where CHD8-knockout mice died after 5.5 embryonic days because of widespread p53-induced apoptosis. Some studies have determined the role of CHD8 in autism spectrum disorder (ASD). CHD8 expression significantly increases during human mid-fetal development.[183] The chromatin remodeling activity and its interaction with transcriptional regulators have shown to play an important role in ASD aetiology.[184] The developing mammalian brain has conserved CHD8 target regions that are associated with ASD risk genes.[186] The knockdown of CHD8 in human neural stem cells results in dysregulation of ASD risk genes that are targeted by CHD8.[187] Recently CHD8 has been associated with the regulation of long non-coding RNAs (lncRNAs),[188] and the regulation of X chromosome inactivation (XCI) initiation, via regulation of Xist long non-coding RNA,[ambiguous] the master regulator of XCI,[ambiguous] though competitive binding to Xist regulatory regions.[189]

 

Some ASD is associated with clearly genetic conditions, like fragile X syndrome, but only around 2% of autistic people have fragile X.[122] Hypotheses from evolutionary psychiatry suggest that these genes persist because they are linked to human inventiveness, intelligence or systemising.[190][191]

 

Current research suggests that genes that increase susceptibility to ASD are ones that control protein synthesis in neuronal cells in response to cell needs, activity and adhesion of neuronal cells, synapse formation and remodeling, and excitatory to inhibitory neurotransmitter balance. Therefore, although up to 1,000 different genes are thought to increase the risk of ASD, all of them eventually affect normal neural development and connectivity between different functional areas of the brain in a similar manner that is characteristic of an ASD brain. Some of these genes are known to modulate production of the GABA neurotransmitter, the nervous system's main inhibitory neurotransmitter. These GABA-related genes are under-expressed in an ASD brain. On the other hand, genes controlling expression of glial and immune cells in the brain, e.g. astrocytes and microglia, respectively, are overexpressed, which correlates with increased number of glial and immune cells found in postmortem ASD brains. Some genes under investigation in ASD pathophysiology are those that affect the mTOR signaling pathway, which supports cell growth and survival.[192]

 

All these genetic variants contribute to the development of the autism spectrum, but it cannot be guaranteed that they are determinants for the development.[193]

 

ASD may be under-diagnosed in women and girls due to an assumption that it is primarily a male condition,[194] but genetic phenomena such as imprinting and X linkage have the ability to raise the frequency and severity of conditions in males, and theories have been put forward for a genetic reason why males are diagnosed more often, such as the imprinted brain hypothesis and the extreme male brain theory.[195][196][197]

 

Early life

See also: Refrigerator mother theory

Several prenatal and perinatal complications have been reported as possible risk factors for autism. These risk factors include maternal gestational diabetes, maternal and paternal age over 30,[198][199][200] bleeding during pregnancy after the first trimester, use of certain prescription medication (e.g. valproate) during pregnancy, and meconium in the amniotic fluid. Research is not conclusive on the relation of these factors to autism, but each of them has been identified more frequently in children with autism compared to their siblings who do not have autism and other typically developing youth.[201] While it is unclear if any single factors during the prenatal phase affect the risk of autism,[202] complications during pregnancy may be a risk.[202]

 

There are also studies being done to test whether certain types of regressive autism have an autoimmune basis.[203]

 

Maternal nutrition and inflammation during preconception and pregnancy influences fetal neurodevelopment. Intrauterine growth restriction is associated with ASD, in both term and preterm infants.[204] Maternal inflammatory and autoimmune diseases may damage fetal tissues, aggravating a genetic problem or damaging the nervous system.[205] Systematic reviews and meta-analyses have found that maternal prenatal infections, prenatal antibiotic exposure, and post-term pregnancies are associated with increased risk of ASD in children.[206][207][208]

 

Exposure to air pollution during child pregnancy, especially heavy metals and particulates, may increase the risk of autism.[209][210] Environmental factors that have been claimed without evidence to contribute to or exacerbate autism include certain foods, infectious diseases, solvents, PCBs, phthalates and phenols used in plastic products, pesticides, brominated flame retardants, alcohol, smoking, illicit drugs, vaccines,[211] and prenatal stress. Some, such as the MMR vaccine, have been completely disproven.[212][213][214][215]

 

Disproven vaccine hypothesis

Main articles: Vaccines and autism and MMR vaccine and autism

Parents may first become aware of ASD symptoms in their child around the time of a routine vaccination. This has led to unsupported and disproven theories blaming vaccine "overload", the vaccine preservative thiomersal, or the MMR vaccine for causing autism spectrum disorder.[216] In 1998, British physician and academic Andrew Wakefield led a fraudulent, litigation-funded study that suggested that the MMR vaccine may cause autism.[217][218][219][220][221]

 

Two versions of the vaccine causation hypothesis were that autism results from brain damage caused by either the MMR vaccine itself, or by mercury used as a vaccine preservative.[222] No convincing scientific evidence supports these claims.[39] They are biologically implausible,[216] and further evidence continues to refute them, including the observation that the rate of autism continues to climb despite elimination of thimerosal from most routine vaccines given to children from birth to 6 years of age.[223][224][225][226][227]

 

A 2014 meta-analysis examined ten major studies on autism and vaccines involving 1.25 million children worldwide; it concluded that neither the vaccine preservative thimerosal (mercury), nor the MMR vaccine, which has never contained thimerosal,[228] lead to the development of ASDs.[229] Despite this, misplaced parental concern has led to lower rates of childhood immunizations, outbreaks of previously controlled childhood diseases in some countries, and the preventable deaths of several children.[230][231]

 

Etiological hypotheses

Several hypotheses have been presented that try to explain how and why autism develops by integrating known causes (genetic and environmental effects) and findings (neurobiological and somatic). Some are more comprehensive, such as the Pathogenetic Triad, which proposes and operationalizes three core features (an autistic personality, cognitive compensation, neuropathological burden) that interact to cause autism,[232] and the Intense World Theory, which explains autism through a hyper-active neurobiology that leads to an increased perception, attention, memory, and emotionality.[233] There are also simpler hypotheses that explain only individual parts of the neurobiology or phenotype of autism, such as mind-blindness (a decreased ability for theory of mind), the weak central coherence theory, or the extreme male brain and empathising–systemising theory.

 

Evolutionary hypotheses

See also: Evolutionary psychology and Pleiotropy § Autism and schizophrenia

Research exploring the evolutionary benefits of autism and associated genes has suggested that autistic people may have played a "unique role in technological spheres and understanding of natural systems" in the course of human development.[234][235] It has been suggested that autism may have arisen as "a slight trade off for other traits that are seen as highly advantageous", providing "advantages in tool making and mechanical thinking", with speculation that the condition may "reveal itself to be the result of a balanced polymorphism, like sickle cell anemia, that is advantageous in a certain mixture of genes and disadvantageous in specific combinations".[236] In 2011, a paper in Evolutionary Psychology proposed that autistic traits, including increased spatial intelligence, concentration and memory, could have been naturally selected to enable self-sufficient foraging in a more (although not completely) solitary environment. This is called the "Solitary Forager Hypothesis".[237][238][239] A 2016 paper examines Asperger syndrome as "an alternative prosocial adaptive strategy" that may have developed as a result of the emergence of "collaborative morality" in the context of small-scale hunter-gathering, i.e., where "a positive social reputation for making a contribution to group wellbeing and survival" becomes more important than complex social understanding.[240]

 

Some research suggests that recent human evolution may be a driving force in the rise of autism in recent human populations. Studies in evolutionary medicine indicate that as cultural evolution outpaces biological evolution, disorders linked to bodily dysfunction increase in prevalence due to lack of contact with pathogens and negative environmental conditions that once widely affected ancestral populations. Because natural selection favors reproduction over health and longevity, the lack of this impetus to adapt to certain harmful circumstances creates a tendency for genes in descendant populations to over-express themselves, which may cause a wide array of maladies, ranging from mental disorders to autoimmune diseases.[241] Conversely, noting the failure to find specific alleles that reliably cause autism or rare mutations that account for more than 5% of the heritable variation in autism established by twin and adoption studies, research in evolutionary psychiatry has concluded that it is unlikely that there is selection pressure for autism when considering that, like schizophrenics, autistic people and their siblings tend to have fewer offspring on average than non-autistic people, and instead that autism is probably better explained as a by-product of adaptive traits caused by antagonistic pleiotropy and by genes that are retained due to a fitness landscape with an asymmetric distribution.[242][243][244]

 

Pathophysiology

Main articles: Mechanism of autism and Pathophysiology of autism

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Diagnosis

Main article: Diagnosis of autism

 

This section should include a summary of Diagnosis of autism. See Wikipedia:Summary style for information on how to incorporate it into this article's main text. (August 2024)

This section is an excerpt from Diagnosis of autism.[edit]

The diagnosis of autism is based on a person's reported and directly observed behavior.[245] There are no known biomarkers for autism spectrum conditions that allow for a conclusive diagnosis.[246]

 

In most cases, diagnostic criteria codified in the World Health Organization's International Classification of Diseases (ICD) or the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM) are used. These reference manuals are regularly updated based on advances in research, systematic evaluation of clinical experience, and healthcare considerations. Currently, the DSM-5 published in 2013 and the ICD-10 that came into effect in 1994 are used, with the latter in the process of being replaced by the ICD-11 that came into effect in 2022 and is now implemented by healthcare systems across the world. Which autism spectrum diagnoses can be made and which criteria are used depends on the local healthcare system's regulations.

 

According to the DSM-5-TR (2022), in order to receive a diagnosis of autism spectrum disorder, one must present with "persistent deficits in social communication and social interaction" and "restricted, repetitive patterns of behavior, interests, or activities."[247] These behaviors must begin in early childhood and affect one's ability to perform everyday tasks. Furthermore, the symptoms must not be fully explainable by intellectual developmental disorder or global developmental delay.

Conditions correlated or comorbid to autism

Main article: Conditions comorbid to autism spectrum disorders

 

Euler diagram showing overlapping clinical phenotypes in genes associated with monogenic forms of autism spectrum disorder (ASD), dystonia, epilepsy and schizophrenia:

Genes associated with epilepsy

Genes associated with schizophrenia

Genes associated with autism spectrum disorder

Genes associated with dystonia

Autism is correlated or comorbid with several personality traits/disorders.[171] Comorbidity may increase with age and may worsen the course of youth with ASDs and make intervention and treatment more difficult. Distinguishing between ASDs and other diagnoses can be challenging because the traits of ASDs often overlap with symptoms of other disorders, and the characteristics of ASDs make traditional diagnostic procedures difficult.[248][249]

 

Correlations

Research indicates that autistic people are significantly more likely to be LGBT than the general population.[33] There is tentative evidence that gender dysphoria occurs more frequently in autistic people.[250][251] A 2021 anonymized online survey of 16- to 90-year-olds revealed that autistic males are more likely to identify as bisexual than their non-autistic peers, while autistic females are more likely to identify as homosexual than non-autistic females do.[252][non-primary source needed]

 

People on the autism spectrum are significantly more likely to be non-theistic than members of the general population.[253]

 

Comorbidities

 

A 2024 Danish cohort study found increased risks for a multitude of comorbid physical diseases, especially in infancy.

The most common medical condition occurring in autistic people is seizure disorder or epilepsy, which occurs in 11–39% of autistic people.[254] The risk varies with age, cognitive level, and type of language disorder.[255]

Tuberous sclerosis, an autosomal dominant genetic condition in which non-malignant tumors grow in the brain and on other vital organs, is present in 1–4% of autistic people.[256]

Intellectual disabilities are some of the most common comorbid disorders with ASDs. As diagnosis is increasingly being given to people with higher functioning autism, there is a tendency for the proportion with comorbid intellectual disability to decrease over time. In a 2019 study, it was estimated that approximately 30–40% of people diagnosed with ASD also have intellectual disability.[257] Recent research has suggested that autistic people with intellectual disability tend to have rarer, more harmful, genetic mutations than those found in people solely diagnosed with autism.[258] A number of genetic syndromes causing intellectual disability may also be comorbid with ASD, including fragile X, Down, Prader-Willi, Angelman, Williams syndrome,[259] branched-chain keto acid dehydrogenase kinase deficiency,[260][261] and SYNGAP1-related intellectual disability.[262][263]

Learning disabilities are also highly comorbid in people with an ASD. Approximately 25–75% of people with an ASD also have some degree of a learning disability.[264] In particular, attention deficit disorder, which is generally more prevalent than autism (ca. 8% vs. 1%), is not directly related, though it is sometimes comorbid with autism.[265]

Various anxiety disorders tend to co-occur with ASDs, with overall comorbidity rates of 7–84%.[266] They are common among children with ASD; there are no firm data, but studies have reported prevalences ranging from 11% to 84%. Many anxiety disorders have symptoms that are better explained by ASD itself or are hard to distinguish from ASD's symptoms.[267]

Rates of comorbid depression in people with an ASD range from 4–58%.[268]

The relationship between ASD and schizophrenia remains a controversial subject under continued investigation, and recent meta-analyses have examined genetic, environmental, infectious, and immune risk factors that may be shared between the two conditions.[269][270][271] Oxidative stress, DNA damage and DNA repair have been postulated to play a role in the aetiopathology of both ASD and schizophrenia.[272]

Deficits in ASD are often linked to behavior problems, such as difficulties following directions, being cooperative, and doing things on other people's terms.[273] Symptoms similar to those of ADHD can be part of an ASD diagnosis.[274]

Sensory processing disorder is also comorbid with ASD, with comorbidity rates of 42–88%.[275]

Starting in adolescence, some people with Asperger syndrome (26% in one sample)[276] fall under the criteria for the similar condition schizoid personality disorder, which is characterized by a lack of interest in social relationships, a tendency towards a solitary or sheltered lifestyle, secretiveness, emotional coldness, detachment and apathy.[276][277][278] Asperger syndrome was traditionally called "schizoid disorder of childhood".

Genetic disorders – about 10–15% of autism cases have an identifiable Mendelian (single-gene) condition, chromosome abnormality, or other genetic syndromes.[279]

Several metabolic defects, such as phenylketonuria, are associated with autistic symptoms.[280]

Gastrointestinal problems are one of the most commonly co-occurring medical conditions in autistic people.[281] These are linked to greater social impairment, irritability, language impairments, mood changes, and behavior and sleep problems.[281][282][283] A 2015 review proposed that immune, gastrointestinal inflammation, malfunction of the autonomic nervous system, gut flora alterations, and food metabolites may cause brain neuroinflammation and dysfunction.[282] A 2016 review concludes that enteric nervous system abnormalities might play a role in neurological disorders such as autism. Neural connections and the immune system are a pathway that may allow diseases originated in the intestine to spread to the brain.[283]

Sleep problems affect about two-thirds of autistic people at some point in childhood. These most commonly include symptoms of insomnia, such as difficulty falling asleep, frequent nocturnal awakenings, and early morning awakenings. Sleep problems are associated with difficult behaviors and family stress, and are often a focus of clinical attention over and above the primary ASD diagnosis.[284]

Dysautonomia is common in ASD, affecting heart rate and blood pressure and causing symptoms such as brain fog, blurry vision, and bowel dysfunction.[285] It can be diagnosed through a Tilt table test.[286]

The frequency of ASD is 10 times higher in mast cell activation syndrome patients than in the general population. This immunological condition causes cardiovascular, dermatological, gastrointestinal, neurological, and respiratory problems.[287]

Management

Main article: Autism therapies

See also: Autism-friendly

There is no treatment as such for autism,[288] and many sources advise that this is not an appropriate goal,[289][290] although treatment of co-occurring conditions remains an important goal.[291] There is no cure for autism, nor can any of the known treatments significantly reduce brain mutations caused by autism, although those who require little to no support are more likely to experience a lessening of symptoms over time.[292][293][294] Several interventions can help children with autism,[295] and no single treatment is best, with treatment typically tailored to the child's needs.[296] Studies of interventions have methodological problems that prevent definitive conclusions about efficacy,[297] but the development of evidence-based interventions has advanced.[298]

 

The main goals of treatment are to lessen associated deficits and family distress, and to increase quality of life and functional independence. In general, higher IQs are correlated with greater responsiveness to treatment and improved treatment outcomes.[299][298] Behavioral, psychological, education, and skill-building interventions may be used to assist autistic people to learn life skills necessary for living independently,[300] as well as other social, communication, and language skills. Therapy also aims to reduce challenging behaviors and build upon strengths.[301]

 

Intensive, sustained special education programs and behavior therapy early in life may help children acquire self-care, language, and job skills.[296] Although evidence-based interventions for autistic children vary in their methods, many adopt a psychoeducational approach to enhancing cognitive, communication, and social skills while minimizing problem behaviors. While medications have not been found to help with core symptoms, they may be used for associated symptoms, such as irritability, inattention, or repetitive behavior patterns.[302]

 

Non-pharmacological interventions

Intensive, sustained special education or remedial education programs and behavior therapy early in life may help children acquire self-care, social, and job skills. Available approaches include applied behavior analysis, developmental models, structured teaching, speech and language therapy, cognitive behavioral therapy,[303] social skills therapy, and occupational therapy.[304] Among these approaches, interventions either treat autistic features comprehensively, or focus treatment on a specific area of deficit.[298] Generally, when educating those with autism, specific tactics may be used to effectively relay information to these people. Using as much social interaction as possible is key in targeting the inhibition autistic people experience concerning person-to-person contact. Additionally, research has shown that employing semantic groupings, which involves assigning words to typical conceptual categories, can be beneficial in fostering learning.[305]

 

There has been increasing attention to the development of evidence-based interventions for autistic young children. Three theoretical frameworks outlined for early childhood intervention include applied behavior analysis (ABA), the developmental social-pragmatic model (DSP) and cognitive behavioral therapy (CBT).[303][298] Although ABA therapy has a strong evidence base, particularly in regard to early intensive home-based therapy, ABA's effectiveness may be limited by diagnostic severity and IQ of the person affected by ASD.[306] The Journal of Clinical Child and Adolescent Psychology has published a paper deeming two early childhood interventions "well-established": individual comprehensive ABA, and focused teacher-implemented ABA combined with DSP.[298]

 

Many people have criticized ABA, calling it unhelpful and unethical.[307][308][309] Sandoval-Norton et al. also discuss the "unintended but damaging consequences, such as prompt dependency, psychological abuse and compliance" that result in autistic people facing challenges as they transition into adulthood.[307] Some ABA advocates have responded to such critiques that, instead of stopping ABA, there should be movement to increase protections and ethical compliance when working with autistic children.[310]

 

Another evidence-based intervention that has demonstrated efficacy is a parent training model, which teaches parents how to implement various ABA and DSP techniques themselves.[298] Various DSP programs have been developed to explicitly deliver intervention systems through at-home parent implementation.

 

In October 2015, the American Academy of Pediatrics (AAP) proposed new evidence-based recommendations for early interventions in ASD for children under 3.[311] These recommendations emphasize early involvement with both developmental and behavioral methods, support by and for parents and caregivers, and a focus on both the core and associated symptoms of ASD.[311] But a Cochrane review found no evidence that early intensive behavioral intervention (EIBI) is effective in reducing behavioral problems associated with autism in most autistic children, though it did improve IQ and language skills. The Cochrane review acknowledged that this may be due to the low quality of studies available on EIBI and therefore providers should recommend EIBI based on their clinical judgment and the family's preferences. No adverse effects of EIBI treatment were found.[312] A meta-analysis in that same database indicates that due to the heterology in ASD, children progress to differing early intervention modalities based on ABA.[313]

 

ASD treatment generally focuses on behavioral and educational interventions to target its two core symptoms: social communication deficits and restricted, repetitive behaviors. If symptoms continue after behavioral strategies have been implemented, some medications can be recommended to target specific symptoms or co-existing problems such as restricted and repetitive behaviors (RRBs), anxiety, depression, hyperactivity/inattention and sleep disturbance.[314] Melatonin, for example, can be used for sleep problems.[315]

 

Several parent-mediated behavioral therapies target social communication deficits in children with autism, but their efficacy in treating RRBs is uncertain.[316]

 

Education

A young child points, in front of a woman who smiles and points in the same direction.

An autistic three-year-old points to fish in an aquarium, as part of an experiment on the effect of intensive shared-attention training on language development.[317]

Educational interventions often used include applied behavior analysis (ABA), developmental models, structured teaching, speech and language therapy and social skills therapy.[296] Among these approaches, interventions either treat autistic features comprehensively, or focalize treatment on a specific area of deficit.[298]

 

The quality of research for early intensive behavioral intervention (EIBI)—a treatment procedure incorporating over 30 hours per week of the structured type of ABA that is carried out with very young children—is low; more vigorous research designs with larger sample sizes are needed.[312] Two theoretical frameworks outlined for early childhood intervention include structured and naturalistic ABA interventions, and developmental social pragmatic models (DSP).[298] One interventional strategy utilizes a parent training model, which teaches parents how to implement various ABA and DSP techniques, allowing for parents to disseminate interventions themselves.[298] Various DSP programs have been developed to explicitly deliver intervention systems through at-home parent implementation. Despite the recent development of parent training models, these interventions have demonstrated effectiveness in numerous studies, being evaluated as a probable efficacious mode of treatment.[298] Early, intensive ABA therapy has demonstrated effectiveness in enhancing communication and adaptive functioning in preschool children;[296][318] it is also well-established for improving the intellectual performance of that age group.[296]

 

In 2018, a Cochrane meta-analysis database concluded that some recent research is beginning to suggest that because of the heterology of ASD, there are two different ABA teaching approaches to acquiring spoken language: children with higher receptive language skills respond to 2.5 to 20 hours per week of the naturalistic approach, whereas children with lower receptive language skills require 25 hou

Diagnostic Scottish Crossbill, Loxia scotica, 15.5 - 17 cm. / 6 - 6.6 in. In ancient pine forest of Scotland. Photographed in June 2008.

 

Grantown-on-Spey, Scotland, Great Britain.

©bryanjsmith.

20/01/2022. Taunton, United Kingdom. Prime Minister Boris Johnson visits Rutherford Diagnostic Centre. Rutherford Diagnostic. The Prime Minister Boris Johnsons visits Rutherford Diagnostic Centre in Taunton. Picture by Andrew Parsons / No 10 Downing Street

Diagnostic tests within the "Sally" app.

20/01/2022. Taunton, United Kingdom. Prime Minister Boris Johnson visits Rutherford Diagnostic Centre. Rutherford Diagnostic. The Prime Minister Boris Johnsons visits Rutherford Diagnostic Centre in Taunton. Picture by Andrew Parsons / No 10 Downing Street

Diagnostic Worm-eating Warbler, Helmitheros vermivorum, 5.25 in. / 13.34 cm. MIGRANT. UNCOMMON to RARE locally in mature deciduous forest, oak woods on relatively dry, rocky slopes with dense understory. Photographed in February 2009. Been a tough bird for me to shoot - only image ever for me!

 

Cottonwood Bosque, Rio Salado Wetlands, Phoenix, Maricopa County, Arizona, United States.

 

©bryanjsmith.

20/01/2022. Taunton, United Kingdom. Prime Minister Boris Johnson visits Rutherford Diagnostic Centre. Rutherford Diagnostic. The Prime Minister Boris Johnsons visits Rutherford Diagnostic Centre in Taunton. Picture by Andrew Parsons / No 10 Downing Street

Molecular Diagnostics lab at UT MD Anderson Cancer Center, August 1, 2012.

Molecular Diagnostics lab at UT MD Anderson Cancer Center, August 1, 2012.

©ITER IO

The first cryomodule for LCLS-II undergoes diagnostics after arriving at SLAC.

 

To learn more, see: home.slac.stanford.edu/news/2018/01-19-superconducting-x-...

 

Credit: Dawn Harmer / SLAC National Accelerator Laboratory

Original Collection:Robert W. Henderson Photographic Collection

 

Item Number: P098:0323

 

You can find this image by searching for the item number by clicking here.

 

Want more? You can find more digital resources online.

 

We're happy for you to share this digital image within the spirit of The Commons; however, certain restrictions on high quality reproductions of the original physical version may apply. To read more about what “no known restrictions” means, please visit the Special Collections & Archives website, or contact staff at the OSU Special Collections & Archives Research Center for details.

 

Dans le cadre du partenariat avec le Projet d’appui au micro, petites et moyennes entreprises (PADMPME), financé par la Banque Mondiale, ONU Femmes a animé un atelier de 2 jours pour soutenir le ministère de l’Entrepreneuriat et des PME dans la réalisation de la première étape de son diagnostic genre. Cette démarche inédite permettra au Ministère et ses démembrements de mieux prendre en compte les besoins des femmes, des hommes et des jeunes entrepreneurs pour soutenir le développement économique inclusif et durable de la République démocratique du Congo. Photo: UN Women/Carlos Ngeleka

Champalimaud Centre for the Unknown, Lisbon Portugal

Charles Correa Associates designed this research and diagnostic centre located in Lisbon. It is a state-of-the-art facility guided by some of the best scientist in the world. The site, where the river meets the Atlantic Ocean, is steeped in history. It is the site where Henry the Navigator, Vasco de Gama and other great Portuguese left on their journeys into the unknown—a perfect metaphor for the discoveries of contemporary science today. The 3 units that constitute the project are:

•the largest for the doctors and scientist,

•the second for the theatre, the exhibition hall, the foundation offices, etc,

•the third is an open-air amphitheatre for the city.

They have been arranged to create a 125m long pathway leading diagonally across the site, towards the open seas. This pathway is ramped up at a gentle slope of 1:20, so as you ascend, you see only sky ahead of you. At the end of the ramp are two stone monoliths, straight from the quarry. When you reach the highest point, you begin to see a large body of water, which seemingly connects (i.e. without any visual break) to the ocean beyond. In the centre of this water body, just below the surface of the water, is an oval shaped object—made of stainless steel and slightly convex, so that it reflects the blue sky and passing clouds above.

 

Beyond its scientific importance, the centre’s design has also caught the attention of architects around the world. The bid to design the site was won by Indian architect Charles Correa, who also designed the Brain and Cognitive Sciences Complex at the Massachusetts Institute of Technology (MIT). The centre features a large interior rainforest connecting clinics and laboratories, chemotherapy suites with gardens, and many areas open for public use, including exhibition halls, an outdoor amphitheatre and landscaped walking areas. It is hoped that the location of the centre in the heart of Lisbon, as well as the openness of the site to the public, will encourage awareness of the centre and the Champalimaud Foundation, as well as the health and medical issues that their work is aiming to address.

 

First, bring up Settings (the gear-shaped thing in the black box on your home screen) and tap About. We want to know everything here, but especially: model, version, capacity, and availability. Take a screen shot of this by pressing the Home button and the power button together; you should see a white flash and hear the camera shutter sound. The screenshot will be automatically saved; we'll go back for it later.

 

Tap Diagnosics & Usage to go to the next screen.

Diagnostic Stripe-throated Jery, Subdesert Jery, Neomixis striatigula pallidior, 12 cm / 4.7 in. ENDEMIC. Found in arid subdesert of SW Madagascar.

 

The Spiny Forest near Ifaty, Toliara, Madagascar.

 

©bryanjsmith.

Molecular Diagnostics lab at UT MD Anderson Cancer Center, August 1, 2012.

 

Diagnostic Surge Suppressor

 

JCM_7149_cr

Therapeutic and diagnostic rooms with medical equipment

Diagnostic Mangrove Finch, Camarhynchus heliobates, 14 cm. CRITICALLY ENDANGERED species, very RARE resident. Mangrove specialist.

 

Black Beach, Isla Isabela, Galapagos Islands, Ecuador.

 

©bryanjsmith.

www.openmedscience.com

 

Aim

 

The Journal of Diagnostic Imaging in Therapy (JDIT) is an international peer-reviewed open access journal to publish original articles on research, letters, communications, reviews and case reports on all aspects regarding the application of Diagnostic Imaging based on radionuclides, X-rays, magnetic resonance, ultrasound and other innovative methods.

 

Scope

 

The scope of these imaging modalities include: positron emission tomography (PET), single photon emission computed tomography (SPECT), hybrid imaging systems, radioguided surgery (RGS) and positron emission mammography (PEM).

 

Also included is the application of short and long-lived radioisotopes in research and development of imaging agents and targeted therapies.

 

In addition, the scope will include magnetic resonance imaging (MRI), computed tomography (CT), ultrasound (US) imaging and planar X-ray (digital, analogue, portable) systems.

 

Readership:

 

Radiologists, Medical Physicists, Radiochemists, PET/SPECT/CT Clinicians, Molecular Imaging Scientists, Pharmacologists, Biochemists, Biotechnologists, Medicinal Chemists, Physicians, Nuclear Medicine Specialists and Technologists, Radiopharmacists, Oncologists, Neurologists, Cardiologists, Psychiatrists, Radiotherapists, Pharmaceutical Scientists and Medical Science Liaison Professionals.

 

JDIT will publish articles in the following subjects:

 

Accelerators * Brachytherapy * Cancer Therapy * Clinical Trials * Computed Tomography (CT) * Cyclotron Technology * Diagnostic Imaging * Dosimetry * Drug Delivery Systems * Echocardiography * High Intensity Focused Ultrasound (HIFU) * Hybrid Imaging Systems * Image Guided Surgery * Imaging Agents * Isotope Production * Magnetic Resonance Imaging * Magnetic Resonance Guided Focused Ultrasound (MRgFUS) * Mammography * Medical Devices * Medical Health Physics * Medical Isotopes * Medical Sensors * Neuroradiology * Nuclear Cardiology * Nuclear Reactors * Positron Emission Mammography (PEM) * Positron Emission Tomography (PET) * Proton Beam Radiotherapy * Radiation and Detection * Radiation Regulatory Issues * Radiobiology * Radioligands * Radiolabelling * Radiation Protection * Radiation Safety * Radiation Therapy * Radio-Guided Surgery (RGS) * Radioimmunology * Radionuclide Imaging * Radiopharmaceuticals * Radiotherapeutics * Radiography * Radiotherapy physics * Single Photon Emission Computed Tomography (SPECT) Imaging * Scintigraphy * Surgical Methods * Targeted Therapies * Tumour Imaging * Ultrasound (US) Imaging * X-rays.