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Dass die Evolution des Menschen noch nicht vorbei ist, liegt so ziemlich auf der Hand. Dass Karl-Heinz die Krone der Schöpfung darstellt, will jetzt wohl auch keiner mehr abstreiten.
Karl-Heinz auf frame-less.com hier und hier
Car: Mitsubishi Lancer Evolution VI.
Engine: 1997cc in-line 4.
Power: 276 BHP.
Year of manufacture: 2001.
Place of registration: Ireland.
Date taken: 1st September 2024.
Album: Carspotting 2024
Technical info
Eye:
Camera: FujiFilm X10
Focal Length: 19.5mm, Macro Mode plus 52mm +4 Close-up lens
Exposure: ISO400, 1/280 @f/3.6, M 4:3
Lighting: Daylight and Yongnuo WJ-60 60-LED ring light
Processing: Photoshop CS3, ring-light reflection removed, added photo of circuit-board, one/zero background and film edge layers also photographed with the FujiFilm X10.
â– Please don't use my images for any purpose, including on websites or blogs, without my explicit permission.
■S.V.P ne pas utiliser cette photo sur un site web, blog ou tout autre média sans ma permission explicite.
© Tom Freda / All rights reserved - Tous droits réservés
Wild animals and birds always find a way to find food. This duckling was with its mother and siblings at Peppa Pig World at the theme park I took Rose and Amy to. They were wandering around all the adults and children as if it were second nature. There is a river that runs alongside the park and that's where they nest and swim, but if they are looking for food into the hubbub of the park they come. I don't think eating fast food is good for them but then it isn't that good for us either
This hike began at South Lake on the Bishop Pass Trail September 8 and 6 days latter ended at North Lake. According to a more accurate account than I can generate we hiked 55 miles, gained 8,730 feet and lost 9,200 feet elevation. This area, part in Kings Canyon National Park and part in the John Muir Wilderness is about 20 miles southwest from Bishop, California.
Here is a brief summary of our route: South Lake Trailhead - Bishop Pass - Dusy Basin - LeConte Canyon - Muir Pass - Evolution Valley - Puite Creek Canyon - Humphrey's Basin - Piute Pass - North Lake Trailhead. We passed more than a dozen lakes some of which I will mention when I upload photos.
IMG_0342
photo of Mitsubishi Lancer Evolution 5 on rally Santa Domenica in Croatia. Testing the new FUJINON LENS XF50-140mm f/2.8 R LM OIS WR.
More from this rally: photoziga.blogspot.com/
Based on the 1986 model year E30 3-Series, the E30 M3 used the BMW S14 engine.
In contrast to later M3 iterations, the E30 M3 was campaigned by BMW as well as other racing teams including Prodrive and AC Schnitzer in many forms of motor sport including rallying and racing. The latter included campaigns in the World Touring Car Championship, Deutsche Tourenwagen Meisterschaft, British Touring Car Championship, Italian Touring Car Championship, French Touring Car Championship and the Australian Touring Car Championship. The production of the E30 road car was to homologate the M3 for Group A Touring Car racing. It was to compete with various models including the "2.3-16V" variant of the Mercedes-Benz W201 190E that was introduced in 1983.
In full race trim, the naturally aspirated 2.3 L S14 engine produced approximately 300 hp (224 kW; 304 PS). With the introduction of the 2.5 L evolution engine into racing in 1990, power increased to approximately 380 hp (283 kW; 385 PS).
The E30 M3 road car[edit]
The road car engine produced 195 PS (143 kW) with a catalytic converter and 215 PS (158 kW) without a catalytic converter for the later version.
The "Evolution" model (also called "EVO2") produced up to 220 PS (160 kW). Other Evolution model changes included larger wheels (16 X 7.5 inches), thinner rear and side window glass, a lighter bootlid, a deeper front splitter and additional rear spoiler. It was only available in coupe and convertible bodies, no saloon option was available.
Later the "Sport Evolution" model production run of 600 (sometimes referred as "EVO3") increased engine displacement to 2.5 L and produced 238 PS (175 kW). Sport Evolution models have enlarged front bumper openings and an adjustable multi-position front splitter and rear wing. Brake cooling ducts were installed in place of front foglights. An additional 786 convertibles were also produced.
[Text from Wikipedia]
this photo is a mix of the artist: BLU
for more: www.youtube.com/charlywashere
video: EVOLUTION OF MEN
Brand is the image of the product in the market. Some people distinguish the psychological aspect of a brand from the experiential aspect. The experiential aspect consists of the sum of all points of contact with the brand and is known as the brand experience. The psychological aspect, sometimes referred to as the brand image, is a symbolic construct created within the minds of people and consists of all the information and expectations associated with a product or service.
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Rajout du massif des trois couronnes, de la villa dans la tempête et du bord d'océan. Evidemment juste les bases (j'ai tout à retravailler plus précisément)...Me restent les goélands, le ciel un peu plus intense à certains endroits et le couple de touristes chics à peindre en esquisse avant un retravail zone par zone. Objectif: recréer avec mon tableau une sorte de pseudo vieille affiche années 20-30 autour de Biarritz et côte basque. Pour garder l'esprit années folles mais avec mon style et sans doute des ajouts de feutres métallisés, de techniques un peu plus élaborées à certains endroits (vagues, personnages, textures bois). C'est du boulot mais je suis contente, ça prend forme progressivement...
Conclusion: Fasting and chemotherapy can work miracles. If you are on chemotherapy, fast three days before chemotherapy and one day after. I am not a doctor.
I recently wrote about one possible reason for the evolution of cancer, as a way to euthanase old-age palaeolithic persons who do not undergo periods of starvation, and are likely therefore to have been free-loading on the charity of their peers. In short I hypothesised that cancer may be a natural granny dumping mechanism.
But that got me to thinking about an even more puzzling evolutionary phenomena: why are there old people at all?
The average lifespan of palaeolithic peoples was about 33 years, which is just as it should be from a straightforward evolutionary perspective. If they started breeding at puberty then your average palaeolith would have had time to raise a few children and then die.
The strange thing is however that then, as till quite modern times, it was the high childhood death rate that suppressed average longevity. If a palaeolithic person reached puberty they lived on average into their mid fifties, way past the menopause and optimal male breeding potential. Further, with the agricultural revolution only a few thousand years ago, biblical and modern humans have palaeolithic bodies -- we have had time to evolve lactose tolerance and little else -- with the potential to live at least three score years and ten and four score if strong (Psalm 90).
Even if older palaeolithic persons were undergoing periods of near starvation and were not free-loading, they would have been consuming food which otherwise may have been gathered by their reproducing peers. So, why did evolution allow such grannies and grandfathers to exist at all? We could easily have evolved to self-destruct at 40. To a palaeolithic society living at the calorific brink of annihilation, the existence of post-breeding-age individuals would seem to be a tremendous calorific waste.
One can think of various 'nice' evolutionary-favoured tasks that post-reproduction-aged palaeolithic people could have performed, such as child minding or as a source of wisdom. I propose a task more tragic: older persons evolved as to function as in vivo experiments, commonly called 'guinea pigs'.
In any hunter gather society -- go out into the woods and try it today -- there would have been a lot of lean times. There would be very few apples, but a vast number of species of berries, bark, and beetles (and that is just the b's) with varying degrees of food value, nutrients, calories and toxicity. When (hunter) gatherers were lucky they found known fruits and roots to fulfil their dietary needs, but they were continually on the brink, regularly going without food, and faced with risky choices of culinary behaviour. "I have not eaten in a week. Do I try these berries or not? Do I give them to my children?"
Herein lies the great evolutionary value of the existence or granny and grandfather aged people like me. "Wait a minute son. Don't eat that. Don't give it to the little one. Let me try it. I will tell you in a day!" (When I think of all my ancestors that surely must have done this it makes me cry.) Societies which contained such individuals would continually increase the variety of gathered food sources and only lose the occasional non-breeding human guinea pig.
I reach this conclusion bearing in mind the miraculous research being carried out NOW on the synergy between chemotherapy and short term starvation in the treatment of cancer. The graph above left (Shi et al., 2012) shows tumour size in mice xenografted with human skin cancer. Cisplatin (CDDP), the most common chemotherapeutic drug, shows negligible effect in reducing tumour size. Short Term Starvation (STS) has a significant but small effect. Short term starvation combined with Cisplatin chemotherapy creates a synergy which seems nothing short of miraculous. 60% percent of the cancerous mice went into remission whereas no or negligible mice went into remission in the other two conditions. The same paper (ibid) also shows similar results, in vitro, with lung cancers.
Dr Valter Longo, the pioneer whose research on fasting lead to the discovery of this chemo-fasting synergy (e.g. Raffaghello, Safdie, Bianchi, Dorff, Fontana, & Longo 2010; Lee, & Longo, 2011), argues that fasting causes ordinary cells to go into hibernation mode, whereas cancer cells keep demanding more food. If in that period of starvation one consumes, or is injected with a toxin, then it is only cancerous cells that are killed. If one keeps fasting for about a day after the consumption or injection of the toxin, until the toxin has left ones system, then the toxin hardly effects normal cells at all.
This synergy between chemotherapy and no-calorie consumption suggests an explanation for both the existence of cancer, and the existence of old people. Old people get cancer. But many of them may be able to cure their own cancer if they undergo regular periods of fasting combined with the consumption of toxins. In modern society this experience is one that perhaps only cancer patients will undergo in the form of chemotherapy but in a (hunter) gathering palaeolithic society it would have experience that would regularly and necessarily have been faced. Going through that starvation plus toxin experience and coming out the other side, or not ("no, don't eat that...urk"), would have been evolutionarily favoured. So evolution worked out a way to create such individuals with that propensity: it created individuals that have a self destruct mechanism that is cured by starvation and toxin consumption. Palaeolithic societies that evolved to have older non-breeding individuals
-- Guinea Pig People (GPPs) -- to do the toxin tasting would have been able to gather and consume more food, breed more and continue the species. And here we are, thanks to all our GPPs.
In conclusion, it seems to me, a non-doctor, from limited research, fasting and chemotherapy can work miracles. If you are on chemotherapy, consult with your oncologist and consider fasting three days before chemotherapy and one day after, because it may cure your cancer, and makes perfect evolutionary sense.
Graph above: Figure 3A and 3B from Shi et al., 2012
Bibliography
Shi, Y., Felley-Bosco, E., Marti, T. M., Orlowski, K., Pruschy, M., & Stahel, R. A. (2012). Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC cancer, 12(1), 1.
bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12...
Lee, C., & Longo, V. D. (2011). Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene, 30(30), 3305-3316.
Nowell, P. C. (1976). The Clonal Evolution of Tumor Cell Populations. Science, 194(4260), 23-28.
Raffaghello, L., Safdie, F., Bianchi, G., Dorff, T., Fontana, L., & Longo, V. D. (2010). Fasting and differential chemotherapy protection in patients. Cell Cycle, 9(22), 4474-4476.
The theory above - post breeding age persons are guinea pigs - is a little similar to the 'disposable soma' theory of the evolution of ageing at a societal rather than cellular level.
rspb.royalsocietypublishing.org/content/205/1161/531.short
"Organisms that do not age are essentially in a steady state in which chronologically young and old individuals are physiologically the same. In this situation the synthesis of macromolecules must be sufficiently accurate to prevent error feedback and the development of lethal 'error catastrophes'. This involves the expenditure of energy, which is required for both kinetic proof-reading and other accuracy promoting devices. It may be selectively advantageous for higher organisms to adopt an energy saving strategy of reduced accuracy in somatic cells." (Kirkwood, Holliday, 1979)
Somatic cells are non-reproductive cells.
These non reproducing cells are argued to be disposable to facilitate greater "proof reading" and prevent "error catastrophes" in the reproducing cells. I am suggesting above that somatic people (non reproducing people) are there, and yet disposable, there to be disposed of, to facilitate "proof reading" (toxin tasting - "reduced accuracy" in diet) and prevent error catastrophes in the non-somatic, reproductive population.
Relatedly
Peto's paradox (there is no correlation between animal size and cancer rate)
www.ncbi.nlm.nih.gov/pmc/articles/PMC3060950/
The assumption that there should be a correlation seems to be based on the assumption that cancer is a random occurrence in cells, so the more of them the greater the chance of cancer, as opposed to a more deliberate, non-random self destruct mechanism proposed here. Cancer is not random. It is a deliberate way of killing old people who do not fast be guinea pigs.