View allAll Photos Tagged Stemcell
Researchers have determined that the protein complex TFIID controls stem cell genes that repair skeletal muscle. This image shows human differentiated skeletal muscle fibers (myotubes, in green) expressing the protein MyoD (stained in red), which cooperates with TFIID in causing muscle stem cells to become muscle tissue. Cell nuclei are stained in blue. This discovery may help develop strategies that activate stem cells to repair muscle degenerated by aging or diseases like muscular dystrophy and cancer.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Alessandra Dall'Agnese, Sanford-Burnham Prebys Medical Discovery Institute
NIH funding from: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Fluorescent microscope image of human embryonic stem cells. Nuclei stained green indicate stem cells. Those stained blue are the surrounding supportive feeder cells.
This photo was taken in the lab of Michael Longaker at the Stanford University School of Medicine.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
An NIH surgical team successfully implanted a patch of tissue made from patient cells with the goal of treating advanced “dry” age-related macular degeneration (AMD), also known as geographic atrophy. Dry AMD is a leading cause of vision loss among older Americans and currently has no treatment.
Read more: www.nih.gov/news-events/news-releases/first-us-patient-re...
Image: Left shows an image of the full-RPE-patch (2 x 4 mm). Each dot is an RPE cell with the borders stained green. Each patch contains approximately 75,000 RPE cells. Right image shows patch RPE cells at higher magnification.
Credit: Kapil Bharti, Ph.D., NEI, NIH
Neurospheres made up of neural stem cells derived from human embryonic stem cells captured using fluorescence microscopy. Some cells (green) are destined to become neurons; others have yet to differentiate (red) or are in transition (yellow).
This photo was taken in the lab of Brian Cummings at the University of California, Irvine.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
Stem cells (stained green) grew throughout the pores of the scaffold (stained red).
More information: www.nih.gov/news-events/nih-research-matters/stem-cells-g...
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Guilak Lab, Washington University
NIH funding from: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
A human embryonic stem cell line derived at Stanford. The line was derived under controlled conditions that could make the cells useful for transplantation. The nuclei in green are stained for a protein that is found only in embryonic stem cells. Blue represents the DNA of the surrounding feeder cells.
This photo was taken in the lab of Julie Baker at the Stanford University School of Medicine.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
Human embryonic stem cells differentiating into precursors cells of the retina. Nuclei are in blue. Pink indicates the presence of Pax6, a protein found in retinal tissue. The retinal pigment epithelium is the tissue responsible for macular degeneration, the most common cause of blindness.
This photo was taken by David Buchholz in the lab of Dennis Clegg at the University of California, Santa Barbara.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
Color-enhanced image taken by a scanning electron microscope of retinal pigment epithelial (RPE) cells derived from human embryonic stem cells. The cells are remarkably similar to normal RPE cells, having a hexagonal shape and growing in a single, well defined layer. These cells are the ones responsible for macular degeneration, the most common cause of blindness. CIRM scientists hope to one day treat macular degeneration with transplanted RPE cells derived from human embryonic stem cells.
The image was taken in the lab of David Hinton at the University of Southern California.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
Induced pluripotent stem cell-derived human brain endothelial cells (iHBMECs) on the vascular channel of the Brain-Chip demonstrate tissue-specific tight junction proteins such as ZO-1 (green). Blue represents Hoechst-stained nuclei.
Credit: Emulate, Inc.
A layer of retinal pigment epithelium (RPE) cells showing the nuclei (red) and cell surface (green). The RPE cells are responsible for macular degeneration, the most common cause of blindness. CIRM scientists hope to treat macular degeneration by transplanting stem cell-derived RPE cells like the ones shown here.
This photo was taken by David Buchholz and Sherry Hikita at the University of California, Santa Barbara.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
iPS cells were reprogrammed from the fibroblasts of a healthy patient, using the four Yamanaka factors. The cells were genetically engineered to express EGFP by TALEN-mediated targeting to the AAVS1 locus. The image captures the constitutive GFP expression of the cells, as well as immunostaining for surface (Tra-1-60) and nuclear (Nanog) pluripotency markers. iPSCs are adult cells that have been genetically reprogrammed to an embryonic stem cell–like state by being forced to express genes and factors important for maintaining the defining properties of embryonic stem cells.
Photographer: Sabrina Heman-Ackah
A nascent retina, generated from a 3D embryonic stem cell culture, containing photoreceptor precursors expressing normal photoreceptor proteins, including the visual pigment, Rhodopsin (green) and the phototransduction enzyme, Recoverin (red). The precursors from such retinae can be isolated and transplanted into adult mice.
Image by Anai Gonzalez-Cordero.
Read the press release at: bit.ly/1dPdfrp
The GFP+ (green) neuron depicted is an embryonic radial glia stem cell.
These cells are found in an area called the ventricular zone during embryonic development and this area unsurprisingly flanks the ventricles of the brain.
These radial glia stem cells will give rise to neurons and glia.
Notice that there appears to be projections moving upwards (towards pial surface) and downwards (toward ventricle) from the soma of the stem cell. These are projections that are important to cellular migration of daughter cells and orienting the stem cell itself.
Image is a ~30 micron thick coronal section of the somatosensory cortex of an embryonic mouse brain.
Blue=DAPI (Binds DNA, marks nucleus)
Red = Pax6 (Transcription factor and marker of pluripotency)
Green = GFP (From jellyfish, used to identify affected cells in an experiment)
A panoramic view of five images demonstrating the complex and long network of neurite outgrowth from hiPSC (human induced pluripotent stem cells)-derived retinal ganglion cells (RGCs), derived through the recapitulation of normal developmental mechanism under the influence of serum free chemically defined media.
Credit: Pooja Teotia & Iqbal Ahmad, University of Nebraska Medical Center
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
NIH funding from: National Eye Institute
Matrix elasticity can regulate stem cell self-renewal and can direct differentiation. This image shows the effect of spatial organization and the magnitude of sub-cellular matrix mechanical properties on human mesenchymal stem cells using hydrogels fabricated with spatially distinct regions. Immunostaining of paxillin in green displays clustered structures, which indicate the formation of mature focal adhesions on the stiff regions of the hydrogel. The nucleus is depicted in blue and F-actin in red.
This photo was chosen as a winner of the 2016 NIH funded research image call.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Chun Yang, Hao Ma and Anouk Killaars, University of Colorado Boulder
NIH funding from: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Human embryonic stem cells differentiated into dopaminergic neurons, which are the ones that degenerate in Parkinson's disease. Working with these cells in a lab dish provides a way to study the origins and possible treatments for Parkinson's disease.
This photo was taken by Jeannie Liu in the lab of Jan Nolta at the University of California, Davis.
In plants, as in animals, stem cells can transform into a variety of different cell types. The stem cells at the growing tip of this Arabidopsis plant will soon become flowers. Arabidopsis is frequently studied by cellular and molecular biologists because it grows rapidly (its entire life cycle is only 6 weeks), produces lots of seeds and has a genome that is easy to manipulate.
Credit: Arun Sampathkumar and Elliot Meyerowitz, California Institute of Technology
Life Magnified:
www.nigms.nih.gov/education/life-magnified/Pages/5_topmid...
Transplanted embryonic stem cell-derived photoreceptors (green) integrate in the adult degenerate mouse retina and contact the next neuron in the retinal circuit, the retinal bipolar cells (red).
Image by Anai Gonzalez-Cordero.
Read the press release at: bit.ly/1dPdfrp
Two colonies of human embryonic stem cells carrying the mutation causing Marfan syndrome. The line was derived from a donated IVF blastocyst determined by pre-implantation genetic diagnosis to have the mutation, which affects 1 in 5000 individuals. This line will allow researchers to study the underlying molecular mechanisms disrupted in Marfan syndrome with the goal of discovering new ways to treat people with the disease.
This photo was taken in the lab of Julie Baker at the Stanford University School of Medicine.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
The cells in green are skin cells directly reprogrammed into heart muscle cells. The red indicates a protein that is unique to heart muscle. The technique used to reprogram the skin cells into heart cells could one day be used to mend heart muscle damaged by disease or heart attack.
The image was taken in the laboratory of Deepak Srivastava at the Gladstone Institute of Cardiovascular Disease.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov.
Heba Degheidy, M.D., Ph.D., a visiting research associate at FDA, stores stem cell samples for analysis in an FDA laboratory on the National Institutes of Health campus in Bethesda, Md.
To learn more about stem cell research, read this FDA Consumer Update:
Adult Stem Cell Research Shows Promise
This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to the U.S. Food and Drug Administration is appreciated but not required.
Privacy and use information: www.flickr.com/people/fdaphotos/
FDA photo by Michael J. Ermarth
Visit advanced-stemcells.euroscicon.com/registration
If you think you can break the #stereotype and revolutionize the treatment methodology using stem cells, then this #conference will serve the best platform to share and gain knowledge
#stemcellstherapy #stemcells #cordblood #Cancer
Detail of integrated embryonic stem cell-derived photoreceptors following transplantation into a degenerate adult mouse retina. The transplanted photoreceptors express the essential phototransduction enzyme, alpha-Transducin (red) which is absent in the recipient retina.
Image by Anai Gonzalez-Cordero.
Read the press release at: bit.ly/1dPdfrp
Human embryonic stem cells in various stages of differentiation into liver cells. Green cells are expressing a fetal liver cell protein called alpha-fetoprotein. Red cells are expressing albumin, a marker of more mature liver cells. Liver cells could one day be used to screen drugs for toxic side effects or for transplantation.
This photo was taken in the lab of Julie Baker at the Stanford University School of Medicine.
Learn more about CIRM-funded stem cell research: www.cirm.ca.gov
Jessica Lo Surdo, M.S. (foreground), an FDA staff scientist, studies chain reactions in stem cells in an FDA laboratory on the National Institutes of Health campus in Bethesda, Md. Ross Marklein, Ph.D., a post-doctoral research fellow (background), records findings.
To learn more about stem cell research, read this FDA Consumer Update:
Adult Stem Cell Research Shows Promise
This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to the U.S. Food and Drug Administration is appreciated but not required.
Privacy and use information: www.flickr.com/people/fdaphotos/
FDA photo by Michael J. Ermarth
Steve Bauer, Ph.D., explains his office's stem cell research. Steve is the chief of the Cellular and Tissues Therapy Branch, Division of Cellular and Gene Therapies, in the Office of Cellular, Tissue and Gene Therapy at FDA’s Center for Biologics Evaluation and Research. He's also a contributor to FDA Voice.
This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to the U.S. Food and Drug Administration is appreciated but not required. For more privacy and use information visit: www.flickr.com/people/fdaphotos/
FDA photo by Michael J. Ermarth
Researchers used artificial intelligence (AI) to evaluate stem cell-derived “patches” of retinal pigment epithelium (RPE) tissue for implanting into the eyes of patients with age-related macular degeneration (AMD), a leading cause of blindness.
The proof-of-principle study helps pave the way for AI-based quality control of therapeutic cells and tissues. The method was developed by researchers at the National Eye Institute (NEI) and the National Institute of Standards and Technology (NIST) and is described in a report appearing online on 11/14/19 in the Journal of Clinical Investigation. NEI is part of the National Institutes of Health.
Read more: www.nih.gov/news-events/news-releases/nih-nist-researcher...
In this image: Scanning electron micrograph showing iPS cell-derived RPE tissue (gray) cultured on a fiber-based scaffold (blue).
Credit: Nathan Hotaling, National Center for Advancing Translational Sciences, NIH
Mesenchymal stromal cells (MSC) or adult stem cells are found in small numbers in most adult tissues, such as bone marrow or fat. Adult stem cells create only similar types of cells. For instance, MSCs could give rise to chondrocytes to form cartilage. The picture shows MSC-derived chrondrocytes in green and the cell nucleus in blue.
Credit: University of California, San Francisco Photo/Dr. Sonja Schrepfer, Xiaomeng Hu, Alessia Gravina, and Dr. Dong Wang
NIH support from: National Center for Advancing Translational Sciences
Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced "dry" form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. The protocols established by the animal study, published January 16 in Science Translational Medicine (STM), set the stage for a first-in-human clinical trial testing the therapy in people with geographic atrophy, for which there is currently no treatment.
As pictured in this illustration, researchers will take a patient's blood cells and convert them in a lab to induced Pluripotent Stem cells (iPS cells) which are capable of becoming any type of cell in the body. iPS cells would then be programmed to become retinal pigment epithelial (RPE) cells, the type of cell that dies early in the geographic atrophy form of AMD.
Read more: www.nih.gov/news-events/news-releases/nih-researchers-res...
Credit: National Eye Institute, NIH
This cross-section of regenerated muscle shows muscle stem cells (red) in their niche along the muscle fibers (green). The blue dots are DNA in the nuclei of the fibers. Researchers have found that injecting the molecule prostaglandin E2 into muscles after injury induces muscle stem cell division and accelerates regeneration. Prostaglandin E2 is an inflammatory molecule released in response to muscle injury or rigorous exercise.
Credit: Helen M. Blau, Ph.D., Andrew T.V. Ho, Ph.D., and Adelaida R. Palla, Ph.D., Stanford University School of Medicine.
NIH support from: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Human salivary stem/progenitor cell (hS/PC) populations cultured from parotid glands are used in our hyaluronic-acid based hydrogel system. hS/PCs form three-dimensional multicellular structures (nuclei in blue) that dynamically organize and mature into coordinated units that respond to neurotransmitters (filamentous actin in green). Organization of these cells into functional secretory units is a critical step in our mission to assist in the relief of xerostomia, or dry mouth, in head and neck cancer patients who have received radiation treatment.
This image was chosen as a winner of the 2016 NIH funded research image call.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Danielle Wu, Farach-Carson Lab at Rice University.
NIH funding from: National Institute of Dental and Craniofacial Research (NIDCR)
An oldie from a couple of Springs back...I really hope we get more in the garden this year.
I apologise for my absence and lack of comments only I've been in hospital for a few days. Good news though...we now have enough stemcells collected for me to go ahead with the transplant on the 18th of this month! I'll be in hospital for a few weeks this time but I'll try and keep in touch from time to time through my computer tablet which David got me for Christmas so that I can go online whilst I'm away. It's going to be a tough time but I'm up for the fight! Wish me luck everyone : )
Scanning electron micrograph of mesenchymal stem cells cultured in an alginate
hydrogel. The hydrogel mechanically induced stem cells differentiation into osteoblasts. The colors show
the elemental composition of the sample: magenta represents phosphorus from the minerals deposited by
the differentiated cells, and blue represents carbon from the hydrogel.
This image was chosen as a winner of the 2016 NIH funded research image call.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Luo Gu, James Weaver, and David J Mooney. School of Engineering and Applied
Sciences, and the Wyss Institute for Biologically Inspired Engineering, Harvard University
NIH funding from: National Institute of Dental and Craniofacial Research (NIDCR)
I just got a bunch of these guys. They are born normal they grow hair, and then it all falls out. These guys were once used for chemical testing. They still use them and they used stemcell research to actually get them to grow the hair back. A little tip I learned is if you keep these as pets, use aspen or anothor non pine or cedar bedding only. I found that pine irritates their eyes real bad. It is almost like hairless mice have allergies. If you keep them in pine the skin around the eyes gets puffy and red and they get sticky. I found clear eyes and no redness in aspen. Their nails get long also. I think that since their is no hair the nutrients go to the nails. I trim them but some people may not be able because they are tiny. You can not breed hairless females unless you have another female to feed the babies. Hairless mice and hamsters have no nipples and CAN NOT feed the babies. They can only be produced by heterozygous females or surrogent mothers.
Megan Sheridan, a graduate student in R. Michael Roberts's lab removes the base solution from a demonstrated sample of stem cells that will be grown into placental cells for study of their interaction with Zika virus. She says that within four days of exposure to the correct hormones, the stem cells are expressing genes of placental cells, and within another day or two start producing placental hormones. The cells are infected with Zika at day four to ensure maximum measuarble interaction, as the stem cells naturally die in culture after about ten days. | photo by Phillip Sitter, Bond LSC
I believe in stem cell research using Gummy Worm's chromosomes. I searched the web for images of chromosomes and realized that Gummy Worms fit perfectly. I also wanted to try french fries dipped in ketsup -- but that will have to wait for my next visit to a local diner ; This photo background was manipulated for a black background in Photoshop as my black velveteen didn't do the trick. MacroMondays — Beliefs
For more information about the Ethics in a Science Classroom Workshop, please visit www.nwabr.org/teachers/ethics-science-classroom
Immunostained coronal section of an embryonic mouse brain.
Green=GFP, Red=Pax6, and Blue=DAPI.
In this experiment the mouse was injected in utero with a plasmid and then electroporated (see the thicker green field on the right side).
Pax6 in the ventricles is labeling radial glial stem cells.
3D reconstruction of a transplanted photoreceptor (green) generated from 3D culture of embryonic stem cells. The newly integrated cell resembles a typical rod photoreceptor.
Image by Colin Chu.
Read the press release at: bit.ly/1dPdfrp
Sandia National Laboratories researchers Bryan Kaehr and Kristin Meyer analyze a silicized surface using optical microscopy and multiphoton fluorescence.
A new silica-based technique to transmute living cells into more permanent materials that defy decay and can endure high-powered probes is widening research opportunities for biologists who are developing cancer treatments, tracking stem cell evolution or even trying to understand how spiders vary the quality of the silk they spin.
Read more at bit.ly/2YDbz7j.
Photo by Randy Montoya.
Jessica Lo Surdo, M.S., an FDA staff scientist, studies chain reactions in stem cells in an FDA laboratory on the National Institutes of Health campus in Bethesda, Md.
To learn more about stem cell research, read this FDA Consumer Update:
Adult Stem Cell Research Shows Promise
This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to the U.S. Food and Drug Administration is appreciated but not required.
Privacy and use information: www.flickr.com/people/fdaphotos/
FDA photo by Michael J. Ermarth