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july 2, 2005. the troubadour. los angeles, ca.

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Integral to the Plot by widdowquinn

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This stuff has eaten up my weekend, so I thought I might as well get something more creative out of it.

Strobist info: SB-600 with stofen, 1/64 just to left of paper, lighting obliquely

Cyber Bully Victim Statistics by kmclaughlin918

According to a survey done by the Cyberbullying Research Center, Cyber bullying victims are more likely to have low self-esteem and to consider suicide.

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World Statistics Day by Mosman Library

How many jelly babies in the jar? We held a guessing competition with the Thursday Kids for World Statisics Day.

7,000,000 Views :-) by Poul-Werner Dam

Thank you all!

Back in October 2018, I reached the 6 Mill. mark - and now passed yet another milestone :-)

7,000,000 views basically since November 2012 - where I started using my Flickr account for good...

Business Statistics by Dragan Sutevski

Thailand - Bangkok - Streetlife - Fried Chicken by Manfred Sommer

Bangkok (English pronunciation: /ˈbæŋkɒk/) is the capital and most populous city of Thailand. It is known in Thai as Krung Thep Maha Nakhon (กรุงเทพมหานคร, pronounced [krūŋ tʰêːp mahǎː nákʰɔ̄ːn] or simply Krung Thep. The city occupies 1,568.7 square kilometres (605.7 sq mi) in the Chao Phraya River delta in Central Thailand, and has a population of over 8 million, or 12.6 percent of the country's population. Over 14 million people (22.2 percent) live within the surrounding Bangkok Metropolitan Region, making Bangkok an extreme primate city, significantly dwarfing Thailand's other urban centres in terms of importance.

Bangkok traces its roots to a small trading post during the Ayutthaya Kingdom in the 15th century, which eventually grew and became the site of two capital cities: Thonburi in 1768 and Rattanakosin in 1782. Bangkok was at the heart of the modernization of Siam - later renamed Thailand - during the late 19th century, as the country faced pressures from the West. The city was at the centre of Thailand's political struggles throughout the 20th century, as the country abolished absolute monarchy, adopted constitutional rule and underwent numerous coups and several uprisings. The city grew rapidly during the 1960s through the 1980s and now exerts a significant impact on Thailand's politics, economy, education, media and modern society.

The Asian investment boom in the 1980s and 1990s led many multinational corporations to locate their regional headquarters in Bangkok. The city is now a major regional force in finance and business. It is an international hub for transport and health care, and has emerged as a regional centre for the arts, fashion and entertainment. The city is well known for its vibrant street life and cultural landmarks, as well as its notorious red-light districts. The historic Grand Palace and Buddhist temples including Wat Arun and Wat Pho stand in contrast with other tourist attractions such as the nightlife scenes of Khaosan Road and Patpong. Bangkok is among the world's top tourist destinations. It is named the most visited city in MasterCard's Global Destination Cities Index, and was named "World's Best City" for four consecutive years by Travel + Leisure magazine.

Bangkok's rapid growth amidst little urban planning and regulation has resulted in a haphazard cityscape and inadequate infrastructure systems. Limited roads, despite an extensive expressway network, together with substantial private car usage, have led to chronic and crippling traffic congestion, which caused severe air pollution in the 1990s. The city has since turned to public transport in an attempt to solve this major problem. Five rapid transit lines are now in operation, with more systems under construction or planned by the national government and the Bangkok Metropolitan Administration.

HISTORY

The history of Bangkok dates at least back to the early 15th century, when it was a village on the west bank of the Chao Phraya River, under the rule of Ayutthaya. Because of its strategic location near the mouth of the river, the town gradually increased in importance. Bangkok initially served as a customs outpost with forts on both sides of the river, and became the site of a siege in 1688 in which the French were expelled from Siam. After the fall of Ayutthaya to the Burmese Empire in 1767, the newly declared King Taksin established his capital at the town, which became the base of the Thonburi Kingdom. In 1782, King Phutthayotfa Chulalok (Rama I) succeeded Taksin, moved the capital to the eastern bank's Rattanakosin Island, thus founding the Rattanakosin Kingdom. The City Pillar was erected on 21 April, which is regarded as the date of foundation of the present city.

Bangkok's economy gradually expanded through busy international trade, first with China, then with Western merchants returning in the early-to-mid 19th century. As the capital, Bangkok was the centre of Siam's modernization as it faced pressure from Western powers in the late 19th century. The reigns of Kings Mongkut (Rama IV, 1851–68) and Chulalongkorn (Rama V, 1868–1910) saw the introduction of the steam engine, printing press, rail transport and utilities infrastructure in the city, as well as formal education and healthcare. Bangkok became the centre stage for power struggles between the military and political elite as the country abolished absolute monarchy in 1932. It was subject to Japanese occupation and Allied bombing during World War II, but rapidly grew in the post-war period as a result of United States developmental aid and government-sponsored investment. Bangkok's role as an American military R&R destination boosted its tourism industry as well as firmly establishing it as a sex tourism destination. Disproportionate urban development led to increasing income inequalities and unprecedented migration from rural areas into Bangkok; its population surged from 1.8 to 3 million in the 1960s. Following the United States' withdrawal from Vietnam in 1973, Japanese businesses took over as leaders in investment, and the expansion of export-oriented manufacturing led to growth of the financial market in Bangkok. Rapid growth of the city continued through the 1980s and early 1990s, until it was stalled by the 1997 Asian financial crisis. By then, many public and social issues had emerged, among them the strain on infrastructure reflected in the city's notorious traffic jams. Bangkok's role as the nation's political stage continues to be seen in strings of popular protests, from the student uprisings in 1973 and 1976, anti-military demonstrations in 1992, and successive anti-government demonstrations by the "Yellow Shirt", "Red Shirt" and "Light blue Shirt" movements from 2008 onwards.

Administration of the city was first formalized by King Chulalongkorn in 1906, with the establishment of Monthon Krung Thep Phra Maha Nakhon (มณฑลกรุงเทพพระมหานคร) as a national subdivision. In 1915 the monthon was split into several provinces, the administrative boundaries of which have since further changed. The city in its current form was created in 1972 with the formation of the Bangkok Metropolitan Administration (BMA), following the merger of Phra Nakhon Province on the eastern bank of the Chao Phraya and Thonburi Province on the west during the previous year.

NAME

The etymology of the name Bangkok (บางกอก, pronounced in Thai as [bāːŋ kɔ̀ːk] is not absolutely clear. Bang is a Thai word meaning "a village situated on a stream", and the name might have been derived from Bang Ko (บางเกาะ), ko meaning "island", a reference to the area's landscape which was carved by rivers and canals. Another theory suggests that it is shortened from Bang Makok (บางมะกอก), makok being the name of Elaeocarpus hygrophilus, a plant bearing olive-like fruit.[a] This is supported by the fact that Wat Arun, a historic temple in the area, used to be named Wat Makok. Officially, however, the town was known as Thonburi Si Mahasamut (ธนบุรีศรีมหาสมุทร, from Pali and Sanskrit, literally "city of treasures gracing the ocean") or Thonburi, according to Ayutthaya chronicles. Bangkok was likely a colloquial name, albeit one widely adopted by foreign visitors, whose continued use of the name finally resulted in it being officially adopted with the creation of the Bangkok Metropolitan Administration.

When King Rama I established his new capital on the river's eastern bank, the city inherited Ayutthaya's ceremonial name, of which there were many variants, including Krung Thep Thawarawadi Si Ayutthaya (กรุงเทพทวารวดีศรีอยุธยา) and Krung Thep Maha Nakhon Si Ayutthaya (กรุงเทพมหานครศรีอยุธยา). Edmund Roberts, visiting the city as envoy of the United States in 1833, noted that the city, since becoming capital, was known as Sia-Yut'hia, and this is the name used in international treaties of the period. Today, the city is known in Thai as Krung Thep Maha Nakhon (กรุงเทพมหานคร) or simply as Krung Thep (กรุงเทพฯ). Its full ceremonial name, which came into use during the reign of King Mongkut, reads as follows:

Krungthepmahanakhon Amonrattanakosin Mahintharayutthaya Mahadilokphop Noppharatratchathaniburirom Udomratchaniwetmahasathan Amonphimanawatansathit Sakkathattiyawitsanukamprasit

กรุงเทพมหานคร อมรรัตนโกสินทร์ มหินทรายุธยา มหาดิลกภพ นพรัตนราชธานีบูรีรมย์ อุดมราชนิเวศน์มหาสถาน อมรพิมานอวตารสถิต สักกะทัตติยวิษณุกรรมประสิทธิ์

The name, composed of Pali and Sanskrit root words, translates as:

City of angels, great city of immortals, magnificent city of the nine gems, seat of the king, city of royal palaces, home of gods incarnate, erected by Vishvakarman at Indra's behest.

The name is listed in Guinness World Records as the world's longest place name, at 168 letters. Thai school children are taught the full name, although few can explain its meaning as many of the words are archaic, and known to few. Most Thais who recall the full name do so because of its use in a popular song, "Krung Thep Maha Nakhon" (1989) by Asanee–Wasan and will often recount it by singing it, much as an English speaker might sing the alphabet song to recite the alphabet. The entirety of the lyrics is just the name of the city repeated over and over.

GOVERNMENT

The city of Bangkok is locally governed by the Bangkok Metropolitan Administration (BMA). Although its boundaries are at the provincial (changwat) level, unlike the other 76 provinces Bangkok is a special administrative area whose governor is directly elected to serve a four-year term. The governor, together with four appointed deputies, form the executive body, who implement policies through the BMA civil service headed by the Permanent Secretary for the BMA. In separate elections, each district elects one or more city councillors, who form the Bangkok Metropolitan Council. The council is the BMA's legislative body, and has power over municipal ordinances and the city's budget. However, after the coup of 2014 all local elections have been cancelled and the council has been appointed by government on September 15 2014. The current Bangkok Governor is Police General Aswin Kwanmuang, who was appointed by the military government on October 26 following the suspension of the last elected governor M.R. Sukhumbhand Paribatra.

Bangkok is subdivided into fifty districts (khet, equivalent to amphoe in the other provinces), which are further subdivided into 169 subdistricts (khwaeng, equivalent to tambon). Each district is managed by a district director appointed by the governor. District councils, elected to four-year terms, serve as advisory bodies to their respective district directors.

The BMA is divided into sixteen departments, each overseeing different aspects of the administration's responsibilities. Most of these responsibilities concern the city's infrastructure, and include city planning, building control, transportation, drainage, waste management and city beautification, as well as education, medical and rescue services. Many of these services are provided jointly with other agencies. The BMA has the authority to implement local ordinances, although civil law enforcement falls under the jurisdiction of the Metropolitan Police Bureau.

The seal of the city shows Hindu god Indra riding in the clouds on Airavata, a divine white elephant known in Thai as Erawan. In his hand Indra holds his weapon, the vajra.[19] The seal is based on a painting done by Prince Naris. The tree symbol of Bangkok is Ficus benjamina. The official city slogan, adopted in 2012, reads:

As built by deities, the administrative center, dazzling palaces and temples, the capital of Thailand

กรุงเทพฯ ดุจเทพสร้าง เมืองศูนย์กลางการปกครอง วัดวังงามเรืองรอง เมืองหลวงของประเทศไทย

As the capital of Thailand, Bangkok is the seat of all branches of the national government. The Government House, Parliament House and Supreme, Administrative and Constitutional Courts are all located within the city. Bangkok is the site of the Grand Palace and Chitralada Villa, respectively the official and de facto residence of the king. Most government ministries also have headquarters and offices in the capital.

GEOGRAPHY

The Bangkok city proper covers an area of 1,568.737 square kilometres, ranking 69th among the other 76 provinces of Thailand. Of this, about 700 square kilometres form the built-up urban area. It is ranked 73rd in the world in terms of land area by City Mayors. The city's urban sprawl reaches into parts of the six other provinces it borders, namely, in clockwise order from northwest: Nonthaburi, Pathum Thani, Chachoengsao, Samut Prakan, Samut Sakhon and Nakhon Pathom. With the exception of Chachoengsao, these provinces, together with Bangkok, form the greater Bangkok Metropolitan Region.

PARKS AND GREEN ZONES

Bangkok has several parks, although these amount to a per-capita total park area of only 1.82 square metres in the city proper. Total green space for the entire city is moderate, at 11.8 square metres per person; however, in the more densely built-up areas of the city these numbers are as low as 1.73 and 0.72 square metres per person. More recent numbers claim that there is only 3.3 m2 of green space per person, compared to an average of 39 m2 in other cities across Asia. Bangkokians thus have 10 times less green space than is standard in the region's urban areas. Green belt areas include about 700 square kilometres of rice paddies and orchards in the eastern and western edges of the city proper, although their primary purpose is to serve as flood detention basins rather than to limit urban expansion. Bang Kachao, a 20-square-kilometre conservation area in an oxbow of the Chao Phraya, lies just across the southern riverbank districts, in Samut Prakan Province. A master development plan has been proposed to increase total park area to 4 square metres per person.

Bangkok's largest parks include the centrally located Lumphini Park near the Si Lom – Sathon business district with an area of 57.6 hectares, the 80-hectare Suanluang Rama IX in the east of the city, and the Chatuchak–Queen Sirikit–Wachirabenchathat park complex in northern Bangkok, which has a combined area of 92 hectares.

DEMOGRAPHY

The city of Bangkok has a population of 8,280,925 according to the 2010 census, or 12.6 percent of the national population. However, there are only 5,692,284 registered residents, belonging to 2,672,423 households. A large number of Bangkok's daytime population commutes from surrounding provinces in the Bangkok Metropolitan Region, the total population of which is 14,565,547. Bangkok is a cosmopolitan city; the census showed that it is home to 81,570 Japanese and 55,893 Chinese nationals, as well as 117,071 expatriates from other Asian countries, 48,341 from Europe, 23,418 from the Americas, 5,289 from Australia and 3,022 from Africa. Immigrants from neighbouring countries include 303,595 Burmese, 63,438 Cambodians and 18,126 Lao.

Although it has been Thailand's largest population centre since its establishment as capital city in 1782, Bangkok grew only slightly throughout the 18th and early 19th centuries. British diplomat John Crawfurd, visiting in 1822, estimated its population at no more than 50,000. As a result of Western medicine brought by missionaries as well as increased immigration from both within Siam and overseas, Bangkok's population gradually increased as the city modernized in the late 19th century. This growth became even more pronounced in the 1930s, following the discovery of antibiotics. Although family planning and birth control was introduced in the 1960s, the lowered birth rate was more than offset by increased migration from the provinces as economic expansion accelerated. Only in the 1990s have Bangkok's population growth rates decreased, following the national rate. Thailand had long since become highly centralized around the capital. In 1980, Bangkok's population was fifty-one times that of Hat Yai and Songkhla, the second-largest urban centre, making it the world's most prominent primate city.

The majority of Bangkok's population are of Thai ethnicity,[d] although details on the city's ethnic make-up are unavailable, as the national census does not document race.[e] Bangkok's cultural pluralism dates back to the early days of its foundation; several ethnic communities were formed by immigrants and forced settlers including the Khmer, Northern Thai, Lao, Vietnamese, Tavoyan, Mon and Malay. Most prominent were the Chinese, who played major roles in the city's trade and became the majority of Bangkok's population - estimates include up to three-fourths in 1828 and almost half in the 1950s. However, Chinese immigration was restricted from the 1930s and effectively ceased after the Chinese Revolution in 1949. Their prominence subsequently declined as most of younger generations of Thai Chinese have integrated and adopted a Thai identity. Bangkok is still nevertheless home to a large Chinese community, with the greatest concentration in Yaowarat, Bangkok's Chinatown. The majority (91 percent) of the city's population is Buddhist. Other religions include Islam (4.7%), Christianity (2.0%), Hinduism (0.5%), Sikhism (0.1%) and Confucianism (0.1%).

Apart from Yaowarat, Bangkok also has several other distinct ethnic neighbourhoods. The Indian community is centred in Phahurat, where the Gurdwara Siri Guru Singh Sabha, founded in 1933, is located. Ban Khrua on Saen Saep Canal is home to descendants of the Cham who settled in the late 18th century. Although the Portuguese who settled during the Thonburi period have ceased to exist as a distinct community, their past is reflected in Santa Kruz Church, on the west bank of the river. Likewise, the Assumption Cathedral on Charoen Krung Road is among many European-style buildings in the Old Farang Quarter, where European diplomats and merchants lived during the late 19th to early 20th centuries. Nearby, the Haroon Mosque is the centre of a Muslim community. Newer expatriate communities exist along Sukhumvit Road, including the Japanese community near Soi Phrom Phong and Soi Thong Lo, and the Arab and North African neighbourhood along Soi Nana. Sukhumvit Plaza, a mall on Soi Sukhumvit 12, is popularly known as Korea Town.

ECONOMY

Bangkok is the economic centre of Thailand, and the heart of the country's investment and development. In 2010, the city had an economic output of 3.142 trillion baht (98.34 billion US dollars), contributing 29.1 percent of the gross domestic product (GDP). This amounted to a per-capita GDP value of ฿456,911 ($14,301), almost three times the national average of ฿160,556 ($5,025). The Bangkok Metropolitan Region had a combined output of ฿4.773tn ($149.39bn), or 44.2 percent of GDP. Bangkok's economy ranks as the sixth among Asian cities in terms of per-capita GDP, after Singapore, Hong Kong, Tokyo, Osaka–Kobe and Seoul.

Wholesale and retail trade is the largest sector in the city's economy, contributing 24.0 percent of Bangkok's gross provincial product. It is followed by manufacturing (14.3%); real estate, renting and business activities (12.4%); transport and communications (11.6%); and financial intermediation (11.1%). Bangkok alone accounts for 48.4 percent of Thailand's service sector, which in turn constitutes 49.0 percent of GDP. When the Bangkok Metropolitan Region is considered, manufacturing is the most significant contributor at 28.2 percent of the gross regional product, reflecting the density of industry in the Bangkok's neighbouring provinces. The automotive industry based around Greater Bangkok is the largest production hub in Southeast Asia. Tourism is also a significant contributor to Bangkok's economy, generating ฿427.5bn ($13.38bn) in revenue in 2010.

The Stock Exchange of Thailand (SET) is located on Ratchadaphisek Road in inner Bangkok. The SET, together with the Market for Alternative Investment (mai) has 648 listed companies as of the end of 2011, with a combined market capitalization of 8.485 trillion baht ($267.64bn). Due to the large amount of foreign representation, Thailand has for several years been a mainstay of the Southeast Asian economy and a centre of Asian business. The Globalization and World Cities Research Network ranks Bangkok as an "Alpha−" world city, and it is ranked 59th in Z/Yen's Global Financial Centres Index 11.

Bangkok is home to the headquarters of all of Thailand's major commercial banks and financial institutions, as well as the country's largest companies. A large number of multinational corporations base their regional headquarters in Bangkok due to the lower cost of the workforce and firm operations relative to other major Asian business centres. Seventeen Thai companies are listed on the Forbes 2000, all of which are based in the capital, including PTT, the only Fortune Global 500 company in Thailand.

Income inequality is a major issue in Bangkok, especially between relatively unskilled lower-income immigrants from rural provinces and neighbouring countries, and middle-class professionals and business elites. Although absolute poverty rates are low - only 0.64 percent of Bangkok's registered residents were living under the poverty line in 2010, compared to a national average of 7.75 - economic disparity is still substantial. The city has a Gini coefficient of 0.48, indicating a high level of inequality.

CULTURE

The culture of Bangkok reflects its position as Thailand's centre of wealth and modernisation. The city has long been the portal of entry of Western concepts and material goods, which have been adopted and blended with Thai values to various degrees by its residents. This is most evident in the lifestyles of the expanding middle class. Conspicuous consumption serves as a display of economic and social status, and shopping centres are popular weekend hangouts. Ownership of electronics and consumer products such as mobile phones is ubiquitous. This has been accompanied by a degree of secularism, as religion's role in everyday life has rather diminished. Although such trends have spread to other urban centres, and, to a degree, the countryside, Bangkok remains at the forefront of social change.

A distinct feature of Bangkok is the ubiquity of street vendors selling goods ranging from food items to clothing and accessories. It has been estimated that the city may have over 100,000 hawkers. While the BMA has authorised the practice in 287 sites, the majority of activity in another 407 sites takes place illegally. Although they take up pavement space and block pedestrian traffic, many of the city's residents depend on these vendors for their meals, and the BMA's efforts to curb their numbers have largely been unsuccessful.

In 2015, however, the BMA, with support from the National Council for Peace and Order (Thailand's ruling military junta), began cracking down on street vendors in a bid to reclaim public space. Many famous market neighbourhoods were affected, including Khlong Thom, Saphan Lek, and the flower market at Pak Khlong Talat. Nearly 15,000 vendors were evicted from 39 public areas in 2016. While some applauded the efforts to focus on pedestrian rights, others have expressed concern that gentrification would lead to the loss of the city's character and adverse changes to people's way of life.

FESTIVALS AND EVENTS

The residents of Bangkok celebrate many of Thailand's annual festivals. During Songkran on 13–15 April, traditional rituals as well as water fights take place throughout the city. Loi Krathong, usually in November, is accompanied by the Golden Mount Fair. New Year celebrations take place at many venues, the most prominent being the plaza in front of CentralWorld. Observances related to the royal family are held primarily in Bangkok. Wreaths are laid at King Chulalongkorn's equestrian statue in the Royal Plaza on 23 October, which is King Chulalongkorn Memorial Day. The present king's and queen's birthdays, respectively on 5 December and 12 August, are marked as Thailand's national Father's Day and national Mother's Day. These national holidays are celebrated by royal audiences on the day's eve, in which the king or queen gives a speech, and public gatherings on the day of the observance. The king's birthday is also marked by the Royal Guards' parade.

Sanam Luang is the site of the Thai Kite, Sport and Music Festival, usually held in March, and the Royal Ploughing Ceremony which takes place in May. The Red Cross Fair at the beginning of April is held at Suan Amporn and the Royal Plaza, and features numerous booths offering goods, games and exhibits. The Chinese New Year (January–February) and Vegetarian Festival (September–October) are celebrated widely by the Chinese community, especially in Yaowarat.

TRANSPORT

Although Bangkok's canals historically served as a major mode of transport, they have long since been surpassed in importance by land traffic. Charoen Krung Road, the first to be built by Western techniques, was completed in 1864. Since then, the road network has vastly expanded to accommodate the sprawling city. A complex elevated expressway network helps bring traffic into and out of the city centre, but Bangkok's rapid growth has put a large strain on infrastructure, and traffic jams have plagued the city since the 1990s. Although rail transport was introduced in 1893 and electric trams served the city from 1894 to 1968, it was only in 1999 that Bangkok's first rapid transit system began operation. Older public transport systems include an extensive bus network and boat services which still operate on the Chao Phraya and two canals. Taxis appear in the form of cars, motorcycles, and "tuk-tuk" auto rickshaws.

Bangkok is connected to the rest of the country through the national highway and rail networks, as well as by domestic flights to and from the city's two international airports. Its centuries-old maritime transport of goods is still conducted through Khlong Toei Port.

The BMA is largely responsible for overseeing the construction and maintenance of the road network and transport systems through its Public Works Department and Traffic and Transportation Department. However, many separate government agencies are also in charge of the individual systems, and much of transport-related policy planning and funding is contributed to by the national government.

ROADS

Road-based transport is the primary mode of travel in Bangkok. Due to the city's organic development, its streets do not follow an organized grid structure. Forty-eight major roads link the different areas of the city, branching into smaller streets and lanes (soi) which serve local neighbourhoods. Eleven bridges over the Chao Phraya link the two sides of the city, while several expressway and motorway routes bring traffic into and out of the city centre and link with nearby provinces.

Bangkok's rapid growth in the 1980s resulted in sharp increases in vehicle ownership and traffic demand, which have since continued - in 2006 there were 3,943,211 in-use vehicles in Bangkok, of which 37.6 percent were private cars and 32.9 percent were motorcycles. These increases, in the face of limited carrying capacity, caused severe traffic congestion evident by the early 1990s. The extent of the problem is such that the Thai Traffic Police has a unit of officers trained in basic midwifery in order to assist deliveries which do not reach hospital in time. While Bangkok's limited road surface area (8 percent, compared to 20–30 percent in most Western cities) is often cited as a major cause of its traffic jams, other factors, including high vehicle ownership rate relative to income level, inadequate public transport systems, and lack of transportation demand management, also play a role. Efforts to alleviate the problem have included the construction of intersection bypasses and an extensive system of elevated highways, as well as the creation of several new rapid transit systems. The city's overall traffic conditions, however, remain bad.

Traffic has been the main source of air pollution in Bangkok, which reached serious levels in the 1990s. However, efforts to improve air quality by improving fuel quality and enforcing emission standards, among others, have been largely successful. Atmospheric particulate matter levels dropped from 81 micrograms per cubic metre in 1997 to 43 in 2007.

Although the BMA has created thirty signed bicycle routes along several roads totalling 230 kilometres, cycling is still largely impractical, especially in the city centre. Most of these bicycle lanes share the pavement with pedestrians. Poor surface maintenance, encroachment by hawkers and street vendors, and a hostile environment for cyclists and pedestrians, make cycling and walking unpopular methods of getting around in Bangkok.

BUSES AND TAXIS

Bangkok has an extensive bus network providing local transit services within the Greater Bangkok area. The Bangkok Mass Transit Authority (BMTA) operates a monopoly on bus services, with substantial concessions granted to private operators. Buses, minibus vans, and song thaeo operate on a total of 470 routes throughout the region. A separate bus rapid transit system owned by the BMA has been in operation since 2010. Known simply as the BRT, the system currently consists of a single line running from the business district at Sathon to Ratchaphruek on the western side of the city. The Transport Co., Ltd. is the BMTA's long-distance counterpart, with services to all provinces operating out of Bangkok.

Taxis are ubiquitous in Bangkok, and are a popular form of transport. As of August 2012, there are 106,050 cars, 58,276 motorcycles and 8,996 tuk-tuk motorized tricycles cumulatively registered for use as taxis. Meters have been required for car taxis since 1992, while tuk-tuk fares are usually negotiated. Motorcycle taxis operate from regulated ranks, with either fixed or negotiable fares, and are usually employed for relatively short journeys.

Despite their popularity, taxis have gained a bad reputation for often refusing passengers when the requested route is not to the driver's convenience. Motorcycle taxis were previously unregulated, and subject to extortion by organized crime gangs. Since 2003, registration has been required for motorcycle taxi ranks, and drivers now wear distinctive numbered vests designating their district of registration and where they are allowed to accept passengers.

RAIL SYSTEMS

Bangkok is the location of Hua Lamphong Railway Station, the main terminus of the national rail network operated by the State Railway of Thailand (SRT). In addition to long-distance services, the SRT also operates a few daily commuter trains running from and to the outskirts of the city during the rush hour.

Bangkok is currently served by three rapid transit systems: the BTS Skytrain, the underground MRT and the elevated Airport Rail Link. Although proposals for the development of rapid transit in Bangkok had been made since 1975, it was only in 1999 that the BTS finally began operation.

The BTS consists of two lines, Sukhumvit and Silom, with thirty stations along 30.95 kilometres. The MRT opened for use in July 2004, and currently consists of two line, the Blue Line and Purple Line. The Airport Rail Link, opened in August 2010, connects the city centre to Suvarnabhumi Airport to the east. Its eight stations span a distance of 28 kilometres.

Although initial passenger numbers were low and their service area remains limited to the inner city, these systems have become indispensable to many commuters. The BTS reported an average of 600,000 daily trips in 2012, while the MRT had 240,000 passenger trips per day.

As of 2016, construction work is ongoing to extend BTS and MRT, as well as several additional transit lines, including the Light Red grade-separated commuter rail line. The entire Mass Rapid Transit Master Plan in Bangkok Metropolitan Region consists of eight main lines and four feeder lines totalling 508 kilometres to be completed by 2029. In addition to rapid transit and heavy rail lines, there have been proposals for several monorail systems.

WATER TRANSPORT

Although much diminished from its past prominence, water-based transport still plays an important role in Bangkok and the immediate upstream and downstream provinces. Several water buses serve commuters daily. The Chao Phraya Express Boat serves thirty-four stops along the river, carrying an average of 35,586 passengers per day in 2010, while the smaller Khlong Saen Saep boat service serves twenty-seven stops on Saen Saep Canal with 57,557 daily passengers. Long-tail boats operate on fifteen regular routes on the Chao Phraya, and passenger ferries at thirty-two river crossings served an average of 136,927 daily passengers in 2010.

Bangkok Port, popularly known by its location as Khlong Toei Port, was Thailand's main international port from its opening in 1947 until it was superseded by the deep-sea Laem Chabang Port in 1991. It is primarily a cargo port, though its inland location limits access to ships of 12,000 deadweight tonnes or less. The port handled 11,936,855 tonnes of cargo in the first eight months of the 2010 fiscal year, about 22 percent the total of the country's international ports.

AIRPORTS

Bangkok is one of Asia's busiest air transport hubs. Two commercial airports serve the city, the older Don Mueang International Airport and the new Bangkok International Airport, commonly known as Suvarnabhumi. Suvarnabhumi, which replaced Don Mueang as Bangkok's main airport at its opening in 2006, served 52,808,013 passengers in 2015, making it the world's 20th busiest airport by passenger volume. This amount of traffic is already over its designed capacity of 45 million passengers. Don Mueang reopened for domestic flights in 2007, and resumed international services focusing on low-cost carriers in October 2012. Suvarnabhumi is undergoing expansion to increase its capacity to 60 million, which is expected to be completed by 2016.

HEALTH AND EDUCATION

EDUCATION

Bangkok has long been the centre of modern education in Thailand. The first schools in the country were established here in the later 19th century, and there are now 1,351 schools in the city. The city is home to the country's five oldest universities, Chulalongkorn, Thammasat, Kasetsart, Mahidol and Silpakorn, founded between 1917 and 1943. The city has since continued its dominance, especially in higher education; the majority of the country's universities, both public and private, are located in Bangkok or the Metropolitan Region. Chulalongkorn and Mahidol are the only Thai universities to appear in the top 500 of the QS World University Rankings. King Mongkut's University of Technology Thonburi, also located in Bangkok, is the only Thai university in the top 400 of the 2012–13 Times Higher Education World University Rankings.

Over the past few decades the general trend of pursuing a university degree has prompted the founding of new universities to meet the needs of Thai students. Bangkok became not only a place where immigrants and provincial Thais go for job opportunities, but also for a chance to receive a university degree. Ramkhamhaeng University emerged in 1971 as Thailand's first open university; it now has the highest enrolment in the country. The demand for higher education has led to the founding of many other universities and colleges, both public and private. While many universities have been established in major provinces, the Greater Bangkok region remains home to the greater majority of institutions, and the city's tertiary education scene remains over-populated with non-Bangkokians. The situation is not limited to higher education, either. In the 1960s, 60 to 70 percent of 10- to 19-year-olds who were in school had migrated to Bangkok for secondary education. This was due to both a lack of secondary schools in the provinces and perceived higher standards of education in the capital. Although this discrepancy has since largely abated, tens of thousands of students still compete for places in Bangkok's leading schools. Education has long been a prime factor in the centralization of Bangkok and will play a vital role in the government's efforts to decentralize the country.

HEALTHCARE

Much of Thailand's medical resources are disproportionately concentrated in the capital. In 2000, Bangkok had 39.6 percent of the country's doctors and a physician-to-population ratio of 1:794, compared to a median of 1:5,667 among all provinces. The city is home to 42 public hospitals, five of which are university hospitals, as well as 98 private hospitals and 4,063 registered clinics. The BMA operates nine public hospitals through its Medical Service Department, and its Health Department provides primary care through sixty-eight community health centres. Thailand's universal healthcare system is implemented through public hospitals and health centres as well as participating private providers.

Research-oriented medical school affiliates such as Siriraj, King Chulalongkorn Memorial and Ramathibodi Hospitals are among the largest in the country, and act as tertiary care centres, receiving referrals from distant parts of the country. Lately, especially in the private sector, there has been much growth in medical tourism, with hospitals such as Bumrungrad and Bangkok Hospital, among others, providing services specifically catering to foreigners. An estimated 200,000 medical tourists visited Thailand in 2011, making Bangkok the most popular global destination for medical tourism.

CRIME AND SAFETY

Bangkok has a relatively moderate crime rate when compared to urban counterparts around the world.[119] Traffic accidents are a major hazard, while natural disasters are rare. Intermittent episodes of political unrest and occasional terrorist attacks have resulted in losses of life.

Although the crime threat in Bangkok is relatively low, non-confrontational crimes of opportunity such as pick-pocketing, purse-snatching, and credit card fraud occur with frequency. Bangkok's growth since the 1960s has been followed by increasing crime rates partly driven by urbanisation, migration, unemployment and poverty. By the late 1980s, Bangkok's crime rates were about four times that of the rest of the country. The police have long been preoccupied with street crimes ranging from housebreaking to assault and murder. The 1990s saw the emergence of vehicle theft and organized crime, particularly by foreign gangs. Drug trafficking, especially that of ya ba methamphetamine pills, is also chronic.

According to police statistics, the most common complaint received by the Metropolitan Police Bureau in 2010 was housebreaking, with 12,347 cases. This was followed by 5,504 cases of motorcycle thefts, 3,694 cases of assault and 2,836 cases of embezzlement. Serious offences included 183 murders, 81 gang robberies, 265 robberies, 1 kidnapping and 9 arson cases. Offences against the state were by far more common, and included 54,068 drug-related cases, 17,239 cases involving prostitution and 8,634 related to gambling. The Thailand Crime Victim Survey conducted by the Office of Justice Affairs of the Ministry of Justice found that 2.7 percent of surveyed households reported a member being victim of a crime in 2007. Of these, 96.1 percent were crimes against property, 2.6 percent were crimes against life and body, and 1.4 percent were information-related crimes.

Political demonstrations and protests are common in Bangkok. While most events since 1992 had been peaceful, the series of protests alternately staged by the Yellow Shirts and Red Shirts since 2006 have often turned violent. Red Shirt demonstrations during March–May 2010 ended in a crackdown in which 92 were killed, including armed and unarmed protesters, security forces, civilians and journalists. Terrorist incidents have also occurred in Bangkok, most notably the 2015 Bangkok bombing at the Erawan shrine, and also a series of bombings on the 2006–07 New Year's Eve.

WIKIPEDIA

bikeability map by nathan mcneil by Michael Andersen

www.ibpi.usp.pdx.edu/media/McNeil_Bikeability_June2010.pdf

Beauty of statistics... by Nina Voulis

5 9

... until yesterday evening I couldn't imagine that I even would say such a thing. But then I discovered the Gapminder website. I believe they found a way to show the way our world is evolving in a visual and very comprehensive manner. And I love how Hans Rosling explains the relationships between populations and their growth, education, history, economics, environment... (His "bubble" is just lovely!)

Gapminder is certainly worthy for everyone to visit!
Please do!

... and please share it!

Bonkers by Kevin Lane

1 10

It took me around 4 years to get to a million views, but with the new way of calculating statistics, the second million has taken just six months.........

1,000,000 Views by Trudy -

3 20

I like typing in those zeros!

Just a few short weeks ago, I was really happy that my views had exceeded 350,000. Then, a handful of my images made Explore and my stats climbed substantially. Thank you so much to those who have me on their contact list. I appreciate you!

Salary vs years in the field - colored according to position by ynse

2 2

Results of Bioinformatics Jobs Survey.

A spike in the download statistics by MuseScore

The FOSDEM effect? Or rather the effect of being listed at KDE apps, Freshmeat and Softpedia

statistics institute by Svetlana Cekic

2 4

The headquarters of the Spanish National Statistics Institute in Madrid. They were built in 1972, and totally remodeled in 2008 by architect César Ruiz-Larrea and designer José María Cruz Novillo.

Important Statistics by John C Bullas BSc MSc PhD MCIHT MIAT

2 1

Important Statistics funny ones

Statistics :) Thank you!!!5 000 000..:) by Katarina Stefanović

1 14

Twitter Infographics by Katie

Some fun Twitter statistics such as the % of people who don't know what a # is, when the first tweet was sent from space and the most Tweets Per Second.

Photo Source:

www.bitrebels.com/social/twitterpalooza-twitter-statistic...

Estadisticas 2012-03-30 by Francisco S

Nuevo record personal de visitas en un solo día y primeras 100,000 visitas.

New personal record of visits in a single day and first 100,000 visits.

Statistics by Julien Harneis

The education subdivision is responsible for a territory with a population of 150.000. This is their statistics department.

World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5) by rs Vots

_-----------------------------------------

The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021

*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety

*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)

——————————————————————————

(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021

-------------------------------------------------- ---------------------

According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.

The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.

, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent

What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of the cell. The ribosome is the place where protein biosynthesis occurs.

Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.

Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell

(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology

(2) New crown vaccine design, molecular biology and chemical structure, etc.

(3) The generality and particularity of the development of new coronavirus drugs

(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.

(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.

(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities

(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.

(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.

(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.

(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus

(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and

The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.

(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,

Hepatitis virus,

Marburg virus

Sars coronavirus, plague, anthracnose, cholera

and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.

However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.

　　　　 Delta mutant strain

According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.

At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.

(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.

(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.

And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.

, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.

Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2～8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.

(2) Live attenuated vaccine: It is a vaccine made by using artificial targeted mutation methods or by screening live microorganisms with highly weakened or basically non-toxic virulence from the natural world. After inoculation, the live attenuated vaccine has a certain ability to grow and reproduce in the body, which can cause the body to have a reaction similar to a recessive infection or a mild infection, and it is widely used.

(3) Subunit vaccine: Among the multiple specific antigenic determinants carried by macromolecular antigens, only a small number of antigenic sites play an important role in the protective immune response. Separate natural proteins through chemical decomposition or controlled proteolysis, and extract bacteria and virusesVaccines made from fragments with immunological activity are screened out of the special protein structure of, called subunit vaccines. Subunit vaccines have only a few major surface proteins, so they can eliminate antibodies induced by many unrelated antigens, thereby reducing the side effects of the vaccine and related diseases and other side effects caused by the vaccine. (4) Genetically engineered vaccine: It uses DNA recombination biotechnology to direct the natural or synthetic genetic material in the pathogen coat protein that can induce the body's immune response into bacteria, yeast or mammalian cells to make it fully expressed. A vaccine prepared after purification. The application of genetic engineering technology can produce subunit vaccines that do not contain infectious substances, stable attenuated vaccines with live viruses as carriers, and multivalent vaccines that can prevent multiple diseases. This is the second-generation vaccine following the first-generation traditional vaccine. It has the advantages of safety, effectiveness, long-term immune response, and easy realization of combined immunization. It has certain advantages and effects.

New coronavirus drug development, drug targets and chemical modification.

Ligand-based drug design (or indirect drug design planning) relies on the knowledge of other molecules that bind to the target biological target. These other molecules can be used to derive pharmacophore models and structural modalities, which define the minimum necessary structural features that the molecule must have in order to bind to the target. In other words, a model of a biological target can be established based on the knowledge of the binding target, and the model can be used to design new molecular entities and other parts that interact with the target. Among them, the quantitative structure-activity relationship (QSAR) is included, in which the correlation between the calculated properties of the molecule and its experimentally determined biological activity can be derived. These QSAR relationships can be used to predict the activity of new analogs. The structure-activity relationship is very complicated.

Based on structure

Structure-based drug design relies on knowledge of the three-dimensional structure of biological targets obtained by methods such as X-ray crystallography or NMR spectroscopy and quantum chemistry. If the experimental structure of the target is not available, it is possible to create a homology model of the target and other standard models that can be compared based on the experimental structure of the relevant protein. Using the structure of biological targets, interactive graphics and medical chemists’ intuitive design can be used to predict drug candidates with high affinity and selective binding to the target. Various automatic calculation programs can also be used to suggest new drug candidates.

The current structure-based drug design methods can be roughly divided into three categories. The 3D method is to search a large database of small molecule 3D structures to find new ligands for a given receptor, in order to use a rapid approximate docking procedure to find those suitable for the receptor binding pocket. This method is called virtual screening. The second category is the de novo design of new ligands. In this method, by gradually assembling small fragments, a ligand molecule is established within the constraints of the binding pocket. These fragments can be single atoms or molecular fragments. The main advantage of this method is that it can propose novel structures that are not found in any database. The third method is to optimize the known ligand acquisition by evaluating the proposed analogs in the binding cavity.

Bind site ID

Binding site recognition is a step in structure-based design. If the structure of the target or a sufficiently similar homologue is determined in the presence of the bound ligand, the ligand should be observable in that structure, in which case the location of the binding site is small. However, there may not be an allosteric binding site of interest. In addition, only apo protein structures may be available, and it is not easy to reliably identify unoccupied sites that have the potential to bind ligands with high affinity. In short, the recognition of binding sites usually depends on the recognition of pits. The protein on the protein surface can hold molecules the size of drugs, etc. These molecules also have appropriate "hot spots" that drive ligand binding, hydrophobic surfaces, hydrogen bonding sites, and so on.

Drug design is a creative process of finding new drugs based on the knowledge of biological targets. The most common type of drug is small organic molecules that activate or inhibit the function of biomolecules, thereby producing therapeutic benefits for patients. In the most important sense, drug design involves the design of molecules with complementary shapes and charges that bind to their interacting biomolecular targets, and therefore will bind to them. Drug design often but does not necessarily rely on computer modeling techniques. A more accurate term is ligand design. Although the design technology for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, etc., which must be optimized first before the ligand can become safe and effective. drug. These other features are usually difficult to predict and realize through reasonable design techniques. However, due to the high turnover rate, especially in the clinical stage of drug development, in the early stage of the drug design process, more attention is paid to the selection of drug candidates. The physical and chemical properties of these drug candidates are expected to be reduced during the development process. Complications are therefore more likely to lead to the approval of the marketed drug. In addition, in early drug discovery, in vitro experiments with computational methods are increasingly used to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological characteristics. A more accurate term is ligand design. Although the design technique for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, iatrogenic effects, etc., which must be optimized first, and then the ligand To become safe and effective.

For drug targets, two aspects should be considered when selecting drug targets:

1. The effectiveness of the target, that is, the target is indeed related to the disease, and the symptoms of the disease can be effectively improved by regulating the physiological activity of the target.

2. The side effects of the target. If the regulation of the physiological activity of the target inevitably produces serious side effects, it is inappropriate to select it as the target of drug action or lose its important biological activity. The reference frame of the target should be expanded in multiple dimensions to have a big choice.

3. Search for biomolecular clues related to diseases: use genomics, proteomics and biochip technology to obtain biomolecular information related to diseases, and perform bioinformatics analysis to obtain clue information.

4. Perform functional research on related biomolecules to determine the target of candidate drugs. Multiple targets or individual targets.

5. Candidate drug targets, design small molecule compounds, and conduct pharmacological research at the molecular, cellular and overall animal levels.

Covalent bonding type

The covalent bonding type is an irreversible form of bonding, similar to the organic synthesis reaction that occurs. Covalent bonding types mostly occur in the mechanism of action of chemotherapeutic drugs. For example, alkylating agent anti-tumor drugs produce covalent bonding bonds to guanine bases in DNA, resulting in cytotoxic activity.

. Verify the effectiveness of the target.

Based on the targets that interact with drugs, that is, receptors in a broad sense, such as enzymes, receptors, ion channels, membranes, antigens, viruses, nucleic acids, polysaccharides, proteins, enzymes, etc., find and design reasonable drug molecules. Targets of action and drug screening should focus on multiple points. Drug intermediates and chemical modification. Combining the development of new drugs with the chemical structure modification of traditional drugs makes it easier to find breakthroughs and develop new antiviral drugs. For example, careful selection, modification and modification of existing related drugs that can successfully treat and recover a large number of cases, elimination and screening of invalid drugs from severe death cases, etc., are targeted, rather than screening and capturing needles in a haystack, aimless, with half the effort. Vaccine design should also be multi-pronged and focused. The broad-spectrum, long-term, safety, efficiency and redundancy of the vaccine should all be considered. In this way, it will be more powerful to deal with the mutation and evolution of the virus. Of course, series of vaccines, series of drugs, second-generation vaccines, third-generation vaccines, second-generation drugs, third-generation drugs, etc. can also be developed. Vaccines focus on epidemic prevention, and medicines focus on medical treatment. The two are very different; however, the two complement each other and complement each other. Therefore, in response to large-scale epidemics of infectious diseases, vaccines and various drugs are the nemesis and killers of viral diseases. Of course, it also includes other methods and measures, so I won't repeat them here.

Mainly through the comprehensive and accurate understanding of the structure of the drug and the receptor at the molecular level and even the electronic level, structure-based drug design and the understanding of the structure, function, and drug action mode of the target and the mechanism of physiological activity Mechanism-based drug design.

Compared with the traditional extensive pharmacological screening and lead compound optimization, it has obvious advantages.

Viral RNA replicase, also known as RNA-dependent RNA polymerase (RdRp) is responsible for the replication and transcription of RNA virus genome, and plays a very important role in the process of virus self-replication in host cells, and It also has a major impact on the mutation of the virus, it will change and accelerate the replication and recombination. Because RdRp from different viruses has a highly conserved core structure, the virus replicase is an important antiviral drug target and there are other selection sites, rather than a single isolated target target such as the new coronavirus As with various mutant viruses, inhibitors developed for viral replicase are expected to become a broad-spectrum antiviral drug. The currently well-known anti-coronavirus drug remdesivir (remdesivir) is a drug for viral replicase.

New antiviral therapies are gradually emerging. In addition to traditional polymerase and protease inhibitors, nucleic acid drugs, cell entry inhibitors, nucleocapsid inhibitors, and drugs targeting host cells are also increasingly appearing in the research and development of major pharmaceutical companies. The treatment of mutated viruses is becoming increasingly urgent. The development of drugs for the new coronavirus pneumonia is very important. It is not only for the current global new coronavirus epidemic, but more importantly, it is of great significance to face the severe pneumonia-respiratory infectious disease that poses a huge threat to humans.

There are many vaccines and related drugs developed for the new coronavirus pneumonia, and countries are vying for a while, mainly including the following:

Identification test, appearance, difference in loading, moisture, pH value, osmolality, polysaccharide content, free polysaccharide content, potency test, sterility test, pyrogen test, bacterial endotoxin test, abnormal toxicity test.

Among them: such as sterility inspection, pyrogen inspection, bacterial endotoxin, and abnormal toxicity inspection are indicators closely related to safety.

Polysaccharide content, free polysaccharide content, and efficacy test are indicators closely related to vaccine effectiveness.

Usually, a vaccine will go through a long research and development process of at least 8 years or even more than 20 years from research and development to marketing. The outbreak of the new crown epidemic requires no delay, and the design and development of vaccines is speeding up. It is not surprising in this special period. Of course, it is understandable that vaccine design, development and testing can be accelerated, shortened the cycle, and reduced some procedures. However, science needs to be rigorous and rigorous to achieve great results. The safety and effectiveness of vaccines are of the utmost importance. There must not be a single error. Otherwise, it will be counterproductive and need to be continuously improved and perfected.

Pre-clinical research: The screening of strains and cells is the basic guarantee to ensure the safety, effectiveness, and continuous supply of vaccines. Taking virus vaccines as an example, the laboratory stage needs to carry out strain screening, necessary strain attenuation, strain adaptation to the cultured cell matrix and stability studies in the process of passaging, and explore the stability of process quality, establish animal models, etc. . Choose mice, guinea pigs, rabbits or monkeys for animal experiments according to each vaccine situation. Pre-clinical research generally takes 5-10 years or longer on the premise that the process is controllable, the quality is stable, and it is safe and effective. In order to be safe and effective, a certain redundant design is also needed, so that the safety and effectiveness of the vaccine can be importantly guaranteed.

These include the establishment of vaccine strain/cell seed bank, production process research, quality research, stability research, animal safety evaluation and effectiveness evaluation, and clinical trial programs, etc.

The ARS-CoV-2 genome contains at least 10 ORFs. ORF1ab is converted into a polyprotein and processed into 16 non-structural proteins (NSP). These NSPs have a variety of functional biological activities, physical and chemical reactions, such as genome replication, induction of host mRNA cleavage, membrane rearrangement, autophagosome production, NSP polyprotein cleavage, capping, tailing, methylation, RNA double-stranded Uncoiling, etc., and others, play an important role in the virus life cycle. In addition, SARS-CoV-2 contains 4 structural proteins, namely spike (S), nucleocapsid (N), envelope (E) and membrane (M), all of which are encoded by the 3'end of the viral genome. Among the four structural proteins, S protein is a large multifunctional transmembrane protein that plays an important role in the process of virus adsorption, fusion, and injection into host cells, and requires in-depth observation and research.

1S protein is composed of S1 and S2 subunits, and each subunit can be further divided into different functional domains. The S1 subunit has 2 domains: NTD and RBD, and RBD contains conservative RBM. The S2 subunit has 3 structural domains: FP, HR1 and HR2. The S1 subunit is arranged at the top of the S2 subunit to form an immunodominant S protein.

The virus uses the host transmembrane protease Serine 2 (TMPRSS2) and the endosomal cysteine protease CatB/L to enter the cell. TMPRSS2 is responsible for the cleavage of the S protein to expose the FP region of the S2 subunit, which is responsible for initiating endosome-mediated host cell entry into it. It shows that TMPRSS2 is a host factor necessary for virus entry. Therefore, the use of drugs that inhibit this protease can achieve the purpose of treatment.

mRNA-1273

The mRNA encoding the full length of SARS-CoV-2, and the pre-spike protein fusion is encapsulated into lipid nanoparticles to form mRNA-1273 vaccine. It can induce a high level of S protein specific antiviral response. It can also consist of inactivated antigens or subunit antigens. The vaccine was quickly approved by the FDA and has entered phase II clinical trials. The company has announced the antibody data of 8 subjects who received different immunization doses. The 25ug dose group achieved an effect similar to the antibody level during the recovery period. The 100ug dose group exceeded the antibody level during the recovery period. In the 25ug and 100ug dose groups, the vaccine was basically safe and tolerable, while the 250ug dose group had 3 levels of systemic symptoms.

Viral vector vaccines can provide long-term high-level expression of antigen proteins, induce CTLs, and ultimately eliminate viral infections.

1, Ad5-nCov

A vaccine of SARS-CoV-2 recombinant spike protein expressed by recombinant, replication-deficient type 5 adenovirus (Ad5) vector. Load the optimized full-length S protein gene together with the plasminogen activation signal peptide gene into the E1 and E3 deleted Ad5 vectors. The vaccine is constructed by the Admax system derived from Microbix Biosystem. In phase I clinical trials, RBD (S1 subunit receptor binding domain) and S protein neutralizing antibody increased by 4 times 14 days after immunization, reaching a peak on 28 days. CD4+T and CD8+T cells reached a peak 14 days after immunization. The existing Ad5 immune resistance partially limits the response of antibodies and T cells. This study will be further conducted in the 18-60 age group, receiving 1/3 of the study dose, and follow-up for 3-6 months after immunization.

DNA vaccine

The introduction of antigen-encoding DNA and adjuvants as vaccines is the most innovative vaccine method. The transfected cells stably express the transgenic protein, similar to live viruses. The antigen will be endocytosed by immature DC, and finally provide antigen to CD4 + T, CD8 + T cells (by MHC differentiation) To induce humoral and cellular immunity. Some specificities of the virus and the new coronavirus mutant are different from general vaccines and other vaccines. Therefore, it is worth noting the gene expression of the vaccine. Otherwise, the effectiveness and efficiency of the vaccine will be questioned.

Live attenuated vaccine

DelNS1-SARS-CoV2-RBD

Basic influenza vaccine, delete NS1 gene. Express SARS-CoV-2 RBD domain. Cultured in CEF and MDCK (canine kidney cells) cells. It is more immunogenic than wild-type influenza virus and can be administered by nasal spray.

The viral genome is susceptible to mutation, antigen transfer and drift can occur, and spread among the population. Mutations can vary depending on the environmental conditions and population density of the geographic area. After screening and comparing 7,500 samples of infected patients, scientists found 198 mutations, indicating the evolutionary mutation of the virus in the human host. These mutations may form different virus subtypes, which means that even after vaccine immunization, viral infections may occur. A certain amount of increment and strengthening is needed here.

Inactivated vaccines, adenovirus vector vaccines, recombinant protein vaccines, nucleic acid vaccines, attenuated influenza virus vector vaccines, etc. According to relevant information, there are dozens of new coronavirus vaccines in the world, and more varieties are being developed and upgraded. Including the United States, Britain, China, Russia, India and other countries, there are more R&D and production units.

AZ vaccine

Modena vaccine

Lianya Vaccine

High-end vaccine

Pfizer vaccine

Pfizer-BioNTech

A large study found that the vaccine developed by Pfizer and German biotechnology company BioNTech is 95% effective in preventing COVID-19.

The vaccine is divided into two doses, which are injected every three weeks.

This vaccine uses a molecule called mRNA as its basis. mRNA is a molecular cousin of DNA, which contains instructions to build specific proteins; in this case, the mRNA in the vaccine encodes the coronavirus spike protein, which is attached to the surface of the virus and used to infect human cells. Once the vaccine enters the human body, it will instruct the body's cells to make this protein, and the immune system will learn to recognize and attack it.

Moderna

The vaccine developed by the American biotechnology company Moderna and the National Institute of Allergy and Infectious Diseases (NIAID) is also based on mRNA and is estimated to be 94.5% effective in preventing COVID-19.

Like Pfizer's vaccine, this vaccine is divided into two doses, but injected every four weeks instead of three weeks. Another difference is that the Moderna vaccine can be stored at minus 20 degrees Celsius instead of deep freezing like Pfizer vaccine. At present, the importance of one of the widely used vaccines is self-evident.

Oxford-AstraZeneca

The vaccine developed by the University of Oxford and the pharmaceutical company AstraZeneca is approximately 70% effective in preventing COVID-19-that is, in clinical trials, adjusting the dose seems to improve this effect.

In the population who received two high-dose vaccines (28 days apart), the effectiveness of the vaccine was about 62%; according to early analysis, the effectiveness of the vaccine in those patients who received the half-dose first and then the full-dose Is 90%. However, in clinical trials, participants taking half doses of the drug are wrong, and some scientists question whether these early results are representative.

Sinopharm Group (Beijing Institute of Biological Products, China)

China National Pharmaceutical Group Sinopharm and Beijing Institute of Biological Products have developed a vaccine from inactivated coronavirus (SARS-CoV-2). The inactivated coronavirus is an improved version that cannot be replicated.

Estimates of the effectiveness of vaccines against COVID-19 vary.

Gamaleya Institute

The Gamaleya Institute of the Russian Ministry of Health has developed a coronavirus vaccine candidate called Sputnik V. This vaccine contains two common cold viruses, adenoviruses, which have been modified so that they will not replicate in the human body; the modified virus also contains a gene encoding the coronavirus spike protein.

New crown drugs

There are many small molecule antiviral drug candidates in the clinical research stage around the world. Including traditional drugs in the past and various drugs yet to be developed, antiviral drugs, immune drugs, Gene drugs, compound drugs, etc.

(A) Molnupiravir

Molnupiravir is a prodrug of the nucleoside analog N4-hydroxycytidine (NHC), jointly developed by Merck and Ridgeback Biotherapeutics.

The positive rate of infectious virus isolation and culture in nasopharyngeal swabs was 0% (0/47), while that of patients in the placebo group was 24% (6/25). However, data from the Phase II/III study indicate that the drug has no benefit in preventing death or shortening the length of stay in hospitalized patients.

Therefore, Merck has decided to fully advance the research of 800mg molnupiravir in the treatment of patients with mild to moderate COVID-19.

(B) AT-527

AT-527 is a small molecule inhibitor of viral RNA polymerase, jointly developed by Roche and Atea. Not only can it be used as an oral therapy to treat hospitalized COVID-19 patients, but it also has the potential as a preventive treatment after exposure.

Including 70 high-risk COVID-19 hospitalized patients data, of which 62 patients' data can be used for virological analysis and evaluation. The results of interim virological analysis show that AT-527 can quickly reduce viral load. On day 2, compared with placebo, patients treated with AT-527 had a greater decline in viral load than the baseline level, and the continuous difference in viral load decline was maintained until day 8.

In addition, compared with the control group, the potent antiviral activity of AT-527 was also observed in patients with a baseline median viral load higher than 5.26 log10. When testing by RT-qPCR to assess whether the virus is cleared,

The safety aspect is consistent with previous studies. AT-527 showed good safety and tolerability, and no new safety problems or risks were found. Of course, there is still a considerable distance between experiment and clinical application, and a large amount of experimental data can prove it.

Prokalamide is an AR (androgen receptor) antagonist. Activated androgen receptor AR can induce the expression of transmembrane serine protease (TMPRSS2). TMPRSS2 has a shearing effect on the new coronavirus S protein and ACE2, which can promote the binding of viral spike protein (S protein) to ACE, thereby promoting The virus enters the host cell. Therefore, inhibiting the androgen receptor may inhibit the viral infection process, and AR antagonists are expected to become anti-coronavirus drugs.

Positive results were obtained in a randomized, double-blind, placebo-controlled phase III clinical trial. The data shows that Prokalutamide reduces the risk of death in severely ill patients with new coronary disease by 92%, reduces the risk of new ventilator use by 92%, and shortens the length of hospital stay by 9 days. This shows that procrulamide has a certain therapeutic effect for patients with severe new coronary disease, which can significantly reduce the mortality of patients, and at the same time greatly reduce the new mechanical ventilation and shorten the patient's hospital stay.

With the continuous development of COVID-19 on a global scale, in addition to vaccines and prevention and control measures, we need a multi-pronged plan to control this disease. Oral antiviral therapy undoubtedly provides a convenient treatment option.

In addition, there are other drugs under development and experimentation. In dealing with the plague virus, in addition to the strict control of protective measures, it is very important that various efficient and safe vaccines and various drugs (including medical instruments, etc.) are the ultimate nemesis and killer of the virus.

(A) "Antiviral biological missiles" are mainly drugs for new coronaviruses and mutant viruses, which act on respiratory and lung diseases. The drugs use redundant designs to inhibit new coronaviruses and variant viruses.

(B) "New Coronavirus Epidemic Prevention Tablets" mainly use natural purified elements and chemical structure modifications.

(D) "New Coronavirus Long-acting Oral Tablets" Chemical modification of antiviral drugs, multiple targets, etc.

(E) "New Coronavirus Inhibitors" (injections) are mainly made of chemical drug structure modification and other preparations.

The development of these drugs mainly includes: drug target screening, structure-activity relationship, chemical modification, natural purification, etc., which require a lot of work and experimentation.

Humans need to vigorously develop drugs to deal with various viruses. These drugs are very important for the prevention and treatment of viruses and respiratory infectious diseases, influenza, pneumonia, etc.

The history of human development The history of human evolution, like all living species, will always be accompanied by the survival and development of microorganisms. It is not surprising that viruses and infectious diseases are frequent and prone to occur. The key is to prevent and control them before they happen.

This strain was first discovered in India in October 2020 and was initially called a "double mutant" virus by the media. According to the announcement by the Ministry of Health of India at the end of March this year, the "India New Coronavirus Genomics Alliance" composed of 10 laboratories found in samples collected in Maharashtra that this new mutant strain carries E484Q and L452R mutations. , May lead to immune escape and increased infectivity. This mutant strain was named B.1.617 by the WHO and was named with the Greek letter δ (delta) on May 31.

Shahid Jamil, the dean of the Trivedi School of Biological Sciences at Ashoka University in India and a virologist, said in an interview with the Shillong Times of India that this mutant strain called "double mutation" is not accurate enough. B. 1.617 contains a total of 15 mutations, of which 6 occur on the spike protein, of which 3 are more critical: L452R and E484Q mutations occur on the spike protein and the human cell "Angiotensin Converting Enzyme 2 (ACE2)" receptor In the bound region, L452R improves the ability of the virus to invade cells, and E484Q helps to enhance the immune escape of the virus; the third mutation P681R can also make the virus enter the cell more effectively. (Encyclopedia website)

There are currently dozens of antiviral COVID-19 therapies under development. The large drugmakers Merck and Pfizer are the closest to the end, as expected, a pair of oral antiviral COVID-19 therapies are undergoing advanced human clinical trials.

Merck's drug candidate is called monupiravir. It was originally developed as an influenza antiviral drug several years ago. However, preclinical studies have shown that it has a good effect on SARS and MERS coronavirus.

Monupiravir is currently undergoing in-depth large-scale Phase 3 human trials. So far, the data is so promising that the US government recently pre-ordered 1.7 million courses of drugs at a cost of $1.2 billion. If everything goes according to plan, the company hopes that the drug will be authorized by the FDA for emergency use and be on the market before the end of 2021.

Pfizer's large COVID-19 antiviral drug candidate is more unique. Currently known as PF-07321332, this drug is the first oral antiviral drug to enter human clinical trials, specifically targeting SARS-CoV-2.

Variant of Concern WHO Label First Detected in World First Detected in Washington State

B.1.1.7 Alpha United Kingdom, September 2020 January 2021

B.1.351 Beta South Africa, December 2020 February 2021

P.1 Gamma Brazil, April 2020 March 2021

B.1.617.2 Delta India, October 2020 April 2021

Although this particular molecule was developed in 2020 after the emergence of the new coronavirus, a somewhat related drug called PF-00835231 has been in operation for several years, targeting the original SARS virus. However, the new drug candidate PF-07321332 is designed as a simple pill that can be taken under non-hospital conditions in the initial stages of SARS-CoV-2 infection.

"The protease inhibitor binds to a viral enzyme and prevents the virus from replicating in the cell," Pfizer said when explaining the mechanism of its new antiviral drug. "Protease inhibitors have been effective in the treatment of other viral pathogens, such as HIV and hepatitis C virus, whether used alone or in combination with other antiviral drugs. Currently marketed therapeutic drugs for viral proteases are generally not toxic Therefore, such molecules may provide well-tolerated treatments against COVID-19."

Various studies on other types of antiviral drugs are also gaining momentum. For example, the new coronavirus pneumonia "antiviral biological missile", "new coronavirus prevention tablets", "composite antiviral oral liquid", "new coronavirus long-acting oral tablets", "new coronavirus inhibitors" (injections), etc., are worthy of attention. Like all kinds of vaccines, they will play a major role in preventing and fighting epidemics.

In addition, Japanese pharmaceutical company Shionoyoshi Pharmaceutical is currently conducting a phase 1 trial of a protease inhibitor similar to SARS-CoV-2. This is called S-217622, which is another oral antiviral drug, and hopes to provide people with an easy-to-take pill in the early stages of COVID-19. At present, the research and development of vaccines and various new crown drugs is very active and urgent. Time does not wait. With the passage of time, various new crown drugs will appear on the stage one after another, bringing the gospel to the complete victory of mankind.

The COVID-19 pandemic is far from over. The Delta mutant strain has quickly become the most prominent SARS-CoV-2 strain in the world. Although our vaccine is still maintained, it is clear that we need more tools to combat this new type of coronavirus. Delta will certainly not be the last new SARS-CoV-2 variant we encountered. Therefore, it is necessary for all mankind to persevere and fight the epidemic together.

Overcome illness and meet new challenges. The new crown epidemic and various mutated viruses are very important global epidemic prevention and anti-epidemic top priorities, especially for the current period of time. Vaccine injections, research and development of new drugs, strict prevention and control, wear masks, reduce gatherings, strictly control large gatherings, prevent the spread of various viruses Masks, disinfection and sterilization, lockdown of the city, vaccinations, accounting and testing are very important, but this does not mean that humans can completely overcome the virus. In fact, many spreading and new latently transmitted infections are still unsuccessful. There are detections, such as invisible patients, asymptomatic patients, migratory latent patients, new-onset patients, etc. The struggle between humans and the virus is still very difficult and complicated, and long-term efforts and exploration are still needed, especially for medical research on the new coronavirus. The origin of the disease, the course of the disease, the virus invaded The deep-level path and the reasons for the evolution and mutation of the new coronavirus and the particularity of prevention and treatment, etc.). Therefore, human beings should be highly vigilant and must not be taken lightly. The fierce battle between humans and various viruses must not be slackened. Greater efforts are needed to successfully overcome this pandemic, fully restore the normal life of the whole society, restore the normal production and work order, restore the normal operation of society, economy and culture, and give up food due to choking. Or eager for success, will pay a high price.

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References References are made to web resources, and related images are from web resources and related websites.

Who official website UN .org www.gavi.org/ispe.org

Wikipedia, "The Lancet", "English Journal of Medicine", "Nature", "Science", "Journal of the American Medical Association", etc.

Learning from history: do not flatten the curve of antiviral research!

T Bobrowski, CC Melo-Filho, D Korn, VM Alves...-Drug discovery today, 2020-

go.drugbank.com/

A critical overview of computational approaches employed for COVID-19 drug discovery

EN Muratov, R Amaro, CH Andrade, N Brown...-Chemical Society..., 2021-pubs.rsc.org

Global Research Performance on COVID 19 in Dimensions Database

J Balasubramani, M Anbalagan-2021-researchgate.net

Adoption of a contact tracing app for containing COVID-19: a health belief model approach

M Walrave, C Waeterloos...- JMIR public health and..., 2020-publichealth.jmir.org

Prophylactic Treatment Protocol Against the Severity of COVID-19 Using Melatonin

N Charaa, M Chahed, H Ghedira...-Available at SSRN..., 2020-papers.ssrn.com

　Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet

　Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany, New England Journal of Medicine

The actions of respiratory therapists facing COVID-19

Zhu Jiacheng-Respiratory Therapy, 2021-pesquisa.bvsalud.org

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, The Lancet

　Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China, JAMA, February 7

Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China, JAMA

Delta variant triggers new phase in the pandemic | Science

science.sciencemag.org›

COVID vaccines slash viral spread – but Delta is an unknown

www.nature.com ›articles

Novel coronavirus pneumonia during ophthalmic surgery management strategy and recommendations

YH HUANG, SS LI, X YAO, YR YANG, DH QIN…-jnewmed.com

Delta variant: What is happening with transmission, hospital ...

www.bmj.com

Risk of long QT syndrome in novel coronavirus COVID-19

VN Oslopov, JV Oslopova, EV Hazova…-Kazan medical…, 2020-kazanmedjournal.ru

Study compares mRNA and adenovirus-based SARS-CoV-2 vaccines ...

www.news-medical.net

First molecular-based detection of SARS-CoV-2 virus in the field-collected houseflies

A Soltani, M Jamalidoust, A Hosseinpour, M Vahedi...-Scientific Reports, 2021-nature.com

Covid 19 DELTA Variant Archives-Online essay writing service

sourceessay.com ›tag› covid-19-delta-variant

SARS-CoV-2 Delta variant Likely to become dominant in the ...

www.news-medical.net

Compilation postscript

Once Fang Ruida's research literature on the new crown virus and mutant virus was published, it has been enthusiastically praised by readers and netizens in dozens of countries around the world, and has proposed some amendments and suggestions. Hope to publish a multilingual version of the book as an emergency To meet the needs of many readers around the world, in the face of the new crown epidemic and the prevention and treatment of various mutant viruses, including the general public, college and middle school students, medical workers, medical colleagues and so on. According to the English original manuscript, it will be re-compiled and published. Inconsistencies will be revised separately. Thank you very much.

Jacques Lucy, Geneva, Switzerland, August 2021

*********************************************************************

Leader mondial, scientifique, scientifique médical, virologue, pharmacien et professeur Fangruida (F.D Smith) sur l'épidémie mondiale et l'ennemi juré et la prévention des nouveaux coronavirus et virus mutants (Jacques Lucy 2021v1.5)

_-----------------------------------------

L'ennemi juré et le tueur du nouveau coronavirus et des virus mutés - Développement conjoint de vaccins et de médicaments (Fangruida) Juillet 2021

* La particularité des nouveaux coronavirus et des virus mutants * Le large spectre, la haute efficacité, la redondance et la sécurité de la conception et du développement du nouveau vaccin contre le coronavirus, Redondance et sécurité

* Nouvelle modification de la structure chimique des médicaments contre les coronavirus * Conception et dépistage des médicaments assistés par ordinateur. *"Missile biologique antiviral", "Nouveaux comprimés anti-épidémiques contre le coronavirus", "Liquide oral antiviral composite", "Nouveaux comprimés oraux à action prolongée contre le coronavirus", "Nouveaux inhibiteurs de coronavirus" (injection)

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(leader mondial, scientifique, scientifique médical, biologiste, virologue, pharmacien, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" est un important document de recherche scientifique. Il a maintenant été révisé et réédité par l'auteur original à plusieurs reprises. La compilation est publiée et publiée selon le manuscrit original pour répondre aux besoins des lecteurs et des internautes du monde entier. En même temps, elle est également très bénéfique pour le grand nombre de chercheurs en médicaments cliniques médicaux et de divers experts et universitaires. Nous espérons qu'il sera corrigé dans la réimpression.------Compilé par Jacques Lucy à Genève, août 2021

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Selon les statistiques en temps réel de Worldometer, vers 6h30 le 23 juillet, il y avait un total de 193 323 815 cas confirmés de nouvelle pneumonie coronarienne dans le monde, et un total de 4 150 213 décès. Il y a eu 570 902 nouveaux cas confirmés et 8 766 nouveaux décès dans le monde en une seule journée. Les données montrent que les États-Unis, le Brésil, le Royaume-Uni, l'Inde et l'Indonésie sont les cinq pays avec le plus grand nombre de nouveaux cas confirmés, et l'Indonésie, le Brésil, la Russie, l'Afrique du Sud et l'Inde sont les cinq pays avec le plus grand nombre de nouveaux décès.

Les nouvelles souches de coronavirus et de mutants delta ont été particulièrement graves ces derniers temps. De nombreux pays et lieux ont repris vie et le nombre de cas n'a pas diminué, mais a augmenté.

, Il est digne de vigilance. Bien que de nombreux pays aient renforcé la prévention et le contrôle des vaccins et d'autres mesures de prévention et de contrôle, il existe encore de nombreuses lacunes et carences dans la suppression et la prévention du virus. Le nouveau coronavirus et diverses souches mutantes présentent un certain degré d'antagonisme par rapport aux médicaments traditionnels et à la plupart des vaccins. Bien que la plupart des vaccins aient de grandes propriétés anti-épidémiques et aient des effets et une protection importants et irremplaçables pour la prévention et le traitement, il est impossible d'empêcher complètement la propagation et l'infection des virus. La propagation de la nouvelle pneumonie à virus couronne a été retardée de près de deux ans. Il y a des centaines de millions de personnes infectées dans le monde, des millions de décès, et le temps est long, la propagation est généralisée et des milliards de personnes dans le monde sont parmi Les dommages causés par le virus sont assez terribles, c'est bien connu. Plus urgent

Ce qui est plus grave, c'est que le virus et les souches mutantes n'ont pas complètement reculé, surtout que de nombreuses personnes sont encore infectées et infectées après avoir été injectées avec divers vaccins.L'efficacité du vaccin et la résistance du virus mutant sont dignes des scientifiques médicaux, virologues , les pharmacologues Les zoologistes et autres réfléchissent et analysent sérieusement. La situation épidémique actuelle dans les pays européens et américains, la Chine, le Brésil, l'Inde, les États-Unis, la Russie et d'autres pays s'est considérablement améliorée par rapport à l'année dernière.Cependant, les chiffres pertinents montrent que la situation épidémique mondiale ne s'est pas complètement améliorée, et certains pays et régions sont encore très graves. En particulier, après une utilisation intensive de divers vaccins, des cas surviennent encore, et dans certains endroits ils sont encore très graves, ce qui mérite une grande vigilance. Les mesures de prévention et de contrôle sont très importantes.De plus, les vaccins et divers médicaments antiépidémiques sont les premiers choix nécessaires, et les autres méthodes sont irremplaçables. Il est particulièrement important de développer et de développer des médicaments complets, des médicaments antiviraux, des médicaments immunitaires et des médicaments génétiques. Les expériences de recherche sur les nouveaux coronavirus et virus mutants nécessitent une analyse plus rigoureuse et approfondie des données, des tissus pathogènes pathologiques, des gènes cellulaires, de la chimie moléculaire, de la chimie quantique, etc., ainsi que de la chimie moléculaire des vaccins, de la physique quantique, de la biologie quantique, de l'histologie cytologique, la chimie médicinale et les médicaments Et les symptômes, l'efficacité, la sécurité, l'efficacité à long terme, etc. du vaccin, bien sûr, y compris des dizaines de milliers de cas cliniques et de décès et d'autres informations et preuves de première main. La tâche de l'ARN (acide ribonucléique) dans le corps humain est d'utiliser les informations de notre matériel génétique ADN pour produire des protéines. Il accomplit cette tâche dans le ribosome, la zone productrice de protéines de la cellule. Le ribosome est le lieu où se produit la biosynthèse des protéines.

La médecine en profite : dans la vaccination, l'ARNm produit artificiellement fournit aux ribosomes des instructions pour construire des antigènes pathogènes contre lesquels lutter, par exemple, la protéine de pointe du coronavirus.

Les vaccins vivants traditionnels ou les vaccins inactivés contiennent des antigènes qui provoquent la réaction du système immunitaire. Le vaccin à ARNm est produit dans la cellule

(1) La spécificité des nouveaux coronavirus et virus mutants, etc., virologie et chimie quantique des virus mutants, physique quantique, microbiologie quantique

(2) Nouvelle conception de vaccin couronne, biologie moléculaire et structure chimique, etc.

(3) La généralité et la particularité du développement de nouveaux médicaments contre le coronavirus

(4) Diverses conceptions de médicaments pour la pneumonie à nouveau coronavirus, la chimie médicinale, la pharmacologie, etc., les cellules, les protéines, l'ADN, la chimie des enzymes, la chimie quantique pharmaceutique, la physique quantique pharmaceutique, la biochimie humaine, la biophysique humaine, etc.

(5) Les caractéristiques d'évolution et de mutation du nouveau coronavirus et de divers virus mutants, la nature à long terme, la répétabilité, la résistance aux médicaments et la résistance épidémique du virus, etc.

(6) Pneumonie à nouveau coronavirus et transmission infectieuse de divers nouveaux coronavirus et leurs particularités

(7) La transmission invisible de la pneumonie à nouveau coronavirus et de divers virus mutants chez l'homme ou l'animal, et la symbiose mutuelle de l'infection croisée de diverses bactéries et virus sont également l'une des causes très graves de dommages graves aux nouveaux coronavirus et virus mutants. La virologie, la pathologie, l'étiologie, le séquençage des gènes, la cartographie des gènes et un grand nombre d'études analytiques ont montré qu'il existe de nombreux cas en Chine, aux États-Unis, en Inde, en Russie, au Brésil et dans d'autres pays.

(8) Pour la prévention et le traitement symptomatiques du nouveau coronavirus, la combinaison de divers vaccins et de di

USA of Awesome Map by Joe Wolf

Highly subjective but kind of fun. Courtesy of Andrew Sullivan's blog "The Daily Dish".

Statistics - Industry by Museums of History NSW - State Archives Collection

Diagram showing area under cultivation in NSW in ten Year intervals between 1870 & 1909

Dated: by 11/05/1908

Digital ID: 14086_a005_a005SZ847000034r

Rights: www.records.nsw.gov.au/about-us/rights-and-permissions

We'd love to hear from you if you use our photos.

Many other photos in our collection are available to view and browse on our website using Photo Investigator.

statistics by Maribel de la Torre

july 2, 2005. the troubadour. los angeles, ca.

statistics and probability by Eiahi Kowalski

1 3

Eiahi Kowalski |statistics and probability | Image Source: cambridge.org | 4/29/2015

* SEX SELLS * by screenpunk

Until yesterday Screenpunk had nice curvy flickr statistics that he studied every day for hunting hints on how to improve the photostream to attract more visitors and views.

Screenpunks 'daring' conclusion up to now is/was twofold:

1. people like to make jokes about hamburgers and hotdogs

2. if you upload images with nice ladies on it, you attract visitors.

Screenpunk was just assessing how one can portrait sexy hot dog ladies that you can make fun of, when yesterday the statscurve skyrocketed, flattening out all bumps and curves.

Whassup ... ? Somebody posted a Screenpunk picture on reddit.com and it got some controversy and now viewers come to Screenpunks Photostream like flies to the cake. And what is it they are looking at? Sexy Ladies? Hot Dogs?

Nope, they are looking at a ruggin' doormat !

STATISTICS by Jacques Rollet

MN graduation rate data by Tim Wilson

Presented by MN State Economist Tom Stinson and MN State Demographer Tom Gillaspy at the AMSD state conference Jan. 19, 2011.

001-For the love of figures by Trevor Butcher

2 8

I ran into a feminist who refused to publish my comment on her blog item on a UK feminist blog group because she refused to accept it based on it not being evidence. OK, I thought, sounds fair enough, but I probed further and discovered she wasn't a feminist at all, she was a hierarchy climber who loved statistics to the point it blinded her to the values of loving her fellow human beings. She is of the type common in government offices - can give you no end of suggestions but if you don't fit her model you will be excluded.

I also read somewhere that art works best when the distance between art and experience is as short as possible. Well, I have outlined my experience, here is my art :)

Statistics Magazine by klinning

Statistics Magazine

facebook_chart by David Terrar

Update on actions to stem the overdose crisis in BC by Province of British Columbia

Updated statistics released from the BC Coroners Service show the number of illicit drug overdose deaths increased throughout BC in November. Government and its partners have taken many significant steps to address the overdose crisis in December.

L-R: Dr. Perry Kendall, Provincial Health Officer; Chief Coroner Lisa Lapointe; Clayton Pecknold, Director of Police Services.

Learn more: news.gov.bc.ca/releases/2016HLTH0098-002803

Super-Tetris by Clayton Shonkwiler

The basis for a fun little exercise in statistics and why truly random samples are important.

Statistics Graph by Emma

Visitas 2017-04-14 by Francisco S

Veinticuatro millones de visitas.

Twenty-four million visits.

Civil War Stats by sparker34621

Infographic of Civil War Statistics

smoking statistics, cigarette smoking, by Mbilga

smoking statistics,

cigarette smoking,

RSSmeme Statistics by Benjamin Golub

Important Statistics by John C Bullas BSc MSc PhD MCIHT MIAT

Important Statistics funny ones

statistics. by misscaro

1 5

Exceeded the 3 millionth.... by Alexanyan

20 June 2015

Statistics South Africa releases Consumer Price Index, 21 Sep 2016 by GovernmentZA

Chief Director Patrick Kelly and Deputy Director-General at Stats SA Joe de Beer address members of the media on Statistics South Africa Consumer Price Index, (CPI) for August 2016 held at Tshedimosetso House in Pretoria. (Photo: GCIS)

usage-statistics-2 by Design work archives

p2.Gangstalking.Statistics by Targeted IndividualsNow

.In summary, talking about the perpetrators based on the data from our sample: more than 80 percent of them are not of the main nationality in Russia, their level of intelligence is on average lower than that of the T.I.s, they have health problems from birth, they don’t like sports and don’t have other hobbies, they are not married, they don’t have children in the most productive periods of their lives, they on average quite risk averse in comparison to T.I.s, they avoid working for a certain sub-industry of the military-industrial complex, and patriotism is, probably, no their favorite word. If Russia, as some ‘scientists’ put it,is a “natural laboratory or a natural experiment”, then these results can be and will be generalizable to other countries too.

The results presented here are not the revelations of the last days, but it would be interesting to see the ‘hit-rate’, the number of correctly guessed cases when the perpetrators and those who are behind all of this, open their archives.

www.stopcriminalsinscience.nut.cc/articleeng

For more sophisticated analysis than presented in this video see:

targetedindividualsnow.tumblr.com/post/169076604168/targe...

trust by erope1004