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Within a cell, lysosomes help with recycling and waste removal through a number of pathways. Rich in powerful enzymes that can break down molecules and even entire organelles and bacteria, lysosomes fuse with sacs carrying cellular debris (via autophagy) or pathogens from outside the cell (via phagocytosis). The enzymes chop up the contents into recyclable bits, such as single amino acids, which are then released into the cell for reuse. Any undigested material is shuttled outside of the cell through exocytosis.
Graphic illustrates the process by which lysosomes recycle or get rid of waste in a mammalian cell, through autophagy, phagocytosis and exocytosis.
In this video, we'll be learning how to draw pikachu easy step by step from start to finish. This guide is perfect for anyone who wants to learn how to draw pikachu step by step. We'll be using easy to follow instructions and pictures to help you learn how to draw pikachu. So if you're looking for a how to draw pikachu, then look no further!
How does one explain, with a photograph, the truly awe inspiring experience of tens of thousands of Ross’ Geese flying out to begin their morning? They say a picture is worth a thousand words but I don’t think a thousand words could do justice to the experience, nor does this photo. I really wanted my 11-year-old son to experience nature in one of its most awesome displays. We were not disappointed. When the mass of Ross’s geese flew over our heads, as far as the eye could see, was Ross’s Geese. The only thought I had other than utter total wonderment was, that I sure wish I were wearing a hat. The massive fly-ins and fly-outs of the Ross's Geese and the Lesser Sandhill Cranes made this experience one that my son and I will not forget having shared, for the rest of our lives. Truly something every nature lover should experience.
The 'bollenvelden' (here: Zuid Holland, The Netherlands) are blossoming! In the fields I saw daffodils were almost gone, tulips were starting well, hyacinths were the greatest! These are hyacinths; tens of them ;-)
This image was taken by a camera (S90) lofted by a kite (Triton)
How to sew like Danny Mansmith:
By Alexis Ortiz
Decide on a piece of fabric. Cut the fabric or not, depending on whether you have a size or shape in mind. Lets say you don’t, or haven’t thought that far (I haven’t). Choose a color thread… or just use what’s already loaded and start [to sew]. You may want to sketch an image of something (anything, it could change later) or not… it can be completely “free-hand”. Remember: this is not “free-motion”. The dog-feet should still be up and then there’s the knee lift that you’ll have to engage over and over again, that slightly lifts the presser foot so you can get some of those tighter turns/switchbacks. And voila! 5-10 years later you’re sure to be amazing! Just like Danny Mansmith!
This is an assumption mind you; you will have to sew a lot almost everyday of the week and it’ll also help if your machine is an industrial because more often than not you will be sewing through multiple layers of fabric, paper, vinyl, leather and/or interfacing.
Learn how to make this Best Birthday Minion Cake for your kids birthday party or any other special kiddie occasion. Check out what makes it so special.
Some children were sledding down the Capitol hill on their protest signs. Looked like they were having a great time!
Five images of one girl sledding down the hill pieced together in Photoshop.
Nikon D5000
Lens: 1970s Nikkor-P 105mm f/2.5
Post Processing done in Lightroom 3/Photoshop CS5
After all our exploring was done today, we ran a few errands and bought the girls a Slip-n-Slide. The three of them played all afternoon.
Upon launching herself at the slide, she would exclaim "Let Me Show You How its Done!"
I'm serious. I can't seem to get rid of it, and I need some help, in nice simple language about how to. I'm not on cable TV. I'm on a converter box that lets a very limited number of channels through. Up until recently I could get 3 or 4 public broadcasting stations, very clearly, and one ABC channel pretty clear. My daughter, bless her heart, helped me get it hooked up so I could access DVD player and VHS player, and those pictures do not have the black rectangle. Only the Television images. Any ideas, please?
P. S. It is not about what show is on; I just picked anything to take a picture of where it is black. Thanks.
(0643TVblackrectanglehow2getridofit)
A few weeks ago I met up with a couple of guys from flickr Voluntary Ranger & Steve Liptrot at Tarn Hows in the English Lake District. We had a great day out, the weather was kind and the views were amazing.
Tarn Hows is an area of the Lake District National Park, containing a picturesque tarn, approximately two miles (3.2 km) northeast of Coniston and about one and a half miles (2.5 km) northwest of Hawkshead. It is one of the most popular tourist destinations in the area with over half a million visitors per year in the 1970s and is managed by the National Trust.
Please view large
A close up look at how VMR have set their track up. Rail on a chair and then fixed into the plastic sleeper.
A visit to the Victorian Miniature Railway 08-09-2018.
The Sherwood Forest Faire is a smallish Renaissance Festival about 40 miles SE of Austin. Despite its size, it is a great event - excellent entertainment and a lot of cool people to shoot. These photos are from the last weekend of the 2014 season - it was a great day for the performers and visitors but very bad for photographers - very sunny; lots of harsh shadows and dappled lighting. Despite that, it was a great day - and I can't wait for the 2015 season!
How to Cut Hair Short | Hair Cutting For Men
hoccattochanoi.com/how-to-cut-hair-short-hair-cutting-for...
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Exposure latitude is defined by the satisfactory range between the shadow and highlights at which details can still be visible and color reversal (slide) films are known to have exposure latitudes that are much narrower than black and white, or color negative films. Accurate metering is...
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Read on at: emulsive.org/articles/how-to-work-with-the-narrow-latitud...
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Filed under: #Articles, #Experiments, #Experiments, #Graduated_Filters, #Leica, #Leica_Sofort, #Leica_SuperElmarM_21Mm_F34_ASPH, #Yusuf_Wiryonoputro
Illustration from How The Leopard Got his Spots by Rudyard Kipling.
Download a free copy of the ebook here How The Leopard Got His Spots Ebook
"take a moment to remember how special you are, and how lucky the world is to have you in it."
lacma
los angeles
2003 feb 18
© woolloomooloo / woolloomooloosky. all rights reserved.
Dussehra commemorates the victory of good over evil. It is the day when Lord Rama killed the ten headed demon king Ravana. People throughout India celebrate the auspicious occasion of Dussehra in their own way. Each region has its own specialty. In several regions burning of effigy of Ravana and his subordinates takes place that symbolizes the power of goodness is above all kind of evil powers. As Lord Rama fought a battle of ten days with demon king Ravana to rescue his abducted wife, the day of his victory is called ‘Vijaya Dashmi’ which means the tenth day of victory. It is believed that it is not only the victory of Lord Rama over Ravana but it is the victory of mankind. So the day is celebrated with great religious fervor and believed that whenever evil power will try to rule humanity, God will appear to rescue His devotees.
Flickr user JeremyHall left me a comment on my 'Freezer' photo asking me to post some information on what post-processing I did in his new group, 'How I Did It'... so I am doing just that!
The final photo can be seen here.
I started with three separate images taken with the Canon 40D. I was using Auto Exposure Bracketing, with the camera set to take exposures at -2,0,+2 EV.
(Side note for 40D users! The exposure bracketing on the 40D won't go any further that +-2, but one cool thing that I've found is that you can rotate the control wheel so your middle exposure is set to -2, and your three bracketed shots will actually be -4,-2,0 EV. Scroll the wheel all the way to the other end of the spectrum and you'll have +4, +2, 0 EV... so effectively you've taken five shots between -4 and +4 with two shutter presses!)
So I took those three exposures and used Photoshop to automatically align them. I shot these with a timer on a tripod, so there was no movement between shots... but in cases where there is movement, I find Photoshop does a much better job than Photomatix at aligning the images.
Save that as a tif, open in Photomatix for tonemapping. Really I have found that every photo requires different settings in Photomatix, but all the sliders and options are laid out in plain view so it's very easy to experiment. Recently I've found that I like to 'over-HDR' the image and then selectively scale it back in Photoshop. So the photo labeled 'Photomatix Tonemap' in the image above was really never meant to be seen by anyone other than me :D I dislike that kind of overdone-HDR shot, and if I wasn't planning on doing any other work after tonemapping, I would have set the overall HDR effect much lower. HDR can really help a shot with a wide range of tones, from dark to light... but the downside is all the extreme highlights and shadows are kind of being evened out, which can make things look flat (to me). For example, look at the ceiling in the image labeled 'Photomatix Tonemap' above. The ceiling is nice and detailed, but it also appears that it's getting just as much light as the freezer in the foreground (which you can see is not the case from the original photos). More on this later.
I saved the tonemapped image to another tif, and brought it into Lightroom. There I changed some things which might seem strange. I took the color saturation of the image almost to zero. Then I made large adjustments to the 'Camera Calibration' section to give a cyan cast to the entire image. Then I worked with the 'Split Toning' section to make the shadows a dark blue-purple, and the highlights a yellow-green. I adjusted the tone curve a little bit and saved these adjustments to a preset called 'Decay Cold'.
I applied those presets to the original '0 EV' shot, so I had one blue-green colored tonemapped image (labeled 'Lightroom Adjusted' in the image above) and one blue-green colored original photo (labeled '0 EV Lightroom Adjusted' in the image above).
I brought both of them into Photoshop, placed the HDR shot as the top layer, and added a mask to it. Then I chose a brush with a low hardness setting and started painting over the areas I didn't want such an extreme amount of 'HDR-look'. You can see from the mask that I got rid of a lot of the HDR effect on the front of the freezer, on the ceiling, and on the back wall. I left the most HDR effect in the ice, because I thought it looked awesome :D Lastly, I placed a Brightness/Contrast adjustment layer over everything and used a gradient mask to apply it only to the ceiling - to darken it up. I think this brings back the sense of depth in the shot.
This was by far the most post-processing work I've done on a photo, but it paid off, since it became my most commented on, most favorited, and most interesting photo according to Flickr!
Leave a comment and let me know if this was useful to anyone!
Graphic illustrates two main endpoints of damaged mitochondria in a cell. If detected by the cell’s quality control mechanisms, proteins signal the cell’s disposal system and the mitochondria is degraded. If not detected, the damage can lead to the ejection of mitochondrial DNA fragments that alert the cell’s system for detecting pathogens. These then trigger the inflammation cascade.
Cells have several quality control mechanisms to remove dysfunctional mitochondria. One important mechanism involves the proteins Parkin and PINK1. When a mitochondrion is damaged, PINK1 and Parkin recruit a phagophore, which engulfs the organelle and begins the process of degrading it. When such quality control systems fail, damaged mitochondrial DNA (mtDNA) can escape from the mitochondria. (How this happens is still an open question, but it may exit via special pores or through ruptures in the mitochondrial membrane). Once released, mtDNA fragments can activate molecules such as cGas-STING or inflammasomes, both of which sense foreign DNA from viruses and other invaders. This, in turn, can increase production of cytokines and cause inflammation.
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Read more in Knowable Magazine
Could mitochondria be the key to a healthy brain?
Some researchers suspect these bacterial ancestors living within our cells may contribute to a wide range of neurological and psychiatric disorders
knowablemagazine.org/article/mind/2021/could-mitochondria...
Take a deeper dive: Selected scholarly reviews
Stress and Psychiatric Disorders: The Role of Mitochondria, Annual Review of Clinical Psychology
Mitochondria are sensitive to stress, and studies suggest that the impact of adverse experiences, especially early in life, may alter the organelles in a way that influences the development of psychiatric disorders.
www.annualreviews.org/doi/10.1146/annurev-clinpsy-082719-...
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Knowable Magazine from Annual Reviews is a digital publication that seeks to make scientific knowledge accessible to all. Through compelling articles, beautiful graphics, engaging videos and more, Knowable Magazine explores the real-world impact of research through a journalistic lens. All content is rooted in deep reporting and undergoes a thorough fact-checking before publication.
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How to photograph every inch of a moving truck - Video here: www.youtube.com/watch?v=8xpfPcn0b-I
My latest photographic contraption, dubbed "enVision", which is used for imaging trucks as they enter/exit an intermodal facility (rail/marine terminal, distribution center, etc.).This system will be part of NASCENT's (nascent.com/) arsenal of technology offerings, used to automate terminal operations. This one is installed right here in Charlotte, at the new Norfolk Southern terminal over by the airport. If you're ever in the vicinity of the terminal (West Blvd near 485) at night, the nearly 275,000 lumens of light make it quite easy to locate.
Visual College of Art and Design of Vancouver
626 West Pender Street #500
Vancouver, BC V6B 1V9
(800) 356-8497
Watch full video tutorial: vcad.ca/two-point-perspective/
Find more VCAD tutorials: tutorials.vcad.ca/
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On my blog is a description and how to make your own whiteboard soooo much better than those smudgy boring whitboards.