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+++ DISCLAIMER +++

Nothing you see here is real, even though the conversion or the presented background story might be based historical facts. BEWARE!

 

Some background

A review by the Australian Government's Defense Committee held after World War II recommended that the post-war forces of the RAN be structured around a Task Force incorporating multiple aircraft carriers. Initial plans were for three carriers, with two active and a third in reserve. A Fleet Air Arm was established on 3 July 1947 by the Commonwealth Defense Council to operate aircraft from these. The first, HMAS Sydney, entered service in 1948.

 

Sydney was the only non-US, non-UK aircraft carrier to be involved in the Korean War. Sydney's maiden voyage saw the delivery of the first two squadrons operated by the Fleet Air Arm: 805 Squadron with Hawker Sea Furies, and 816 Squadron with Fairey Fireflies. The RAN's second aircraft carrier, HMAS Melbourne, had encountered delays while upgrading to the latest technology, and the British aircraft carrier HMS Vengeance was loaned to the RAN from 1952 until 1955, when Melbourne was commissioned.

 

At this stage it was clear that the RAN needed some more aerial punch for its new carriers beyond its fast Sea Furies and outdated Fireflies. Hence, search began for a complementary fighter bomber. The Douglas A-1 Skyraider was an initial candidate, but it finally was rejected because it appeared to be too slow and limited to the CAS role. The Westland Wyvern was another candidate, but considered to be too complex and large. Despite the advent of the jet age, a rather simple and robust aircraft with a piston engine was demanded as a ground-attack version for low altitudes. In early 1949, a proven candidate was found: Vought's F4U-5 Corsair, even though in a much modified version.

 

The Corsair was quickly adopted, since time was pressing. But despite the urgency through the Commonwealth Defense Council, the RAN Corsair would considerably differ from its American counterparts: The RAN decided to replace the original Pratt & Whitney R-2800 radial engine with a Rolls Royce Griffon engine. A major change, but the Griffon offered better fuel efficiency and saved overall weight, despite the prominent water radiator bath under the propeller.

 

The longer nose section earned the Australian Corsairs the nickname ‘Longneck’, inspired by typical 750ml bottles of beer in South Australia. These aircraft could also be easily identified through a massive, four-bladed contraprop with a long, pointed spinner. Major benefit of the contraprop was a much improved low speed handling through reduced torque effects and enhanced throttle response - a vital feature on the relatively small Australian carriers' flight decks. This new arrangement changed the Corsair's silhouette completely, but also improved aerodynamics, so that, despite a nominal decrease in power, almost all performance features could be kept.

 

Other obvious external modifications were an enlarged fin with a square shape for better directional stability at low speeds and the introduction of an almost frameless perspex bubble canopy - reminiscent of Goodyear's F2G "Super Corsair" from late WWII and improving both aerodynamics as well as the rearward field of view. Less visible were many British standard equipment pieces, like the Hispano Mk. V cannons, the radio or the electric system. Effectively, almost no part of the Australian Corsairs would be interchangeable with its US cousins!

 

The aircraft were to be assembled in Australia at the Port Melbourne plant of CAC. Raw airframe kits were imported from the USA via ship, as well as the Australian Corsairs' engines, which came directly from Great Britain. A total of 34 ‘Longnecks’ were built from these imported kits. The new aircraft were ready for service in October 1950 and received the official designation ‘Corsair S.1’, All machines were exclusively allocated to 806 Squadron, which was initially based on HMAS Sydney.

 

RAN Corsairs quickly saw hot action, when HMAS Sydney was deployed to Korean waters in late 1951, with a wartime CAG of 805, 806, 808, and 817 Squadrons embarked. The CAG conducted its first raids on 5 October 1951 with 32 sorties mounted in the 'Wales' area in the south-west of North Korea. Six days later, Sydney's CAG flew a light fleet carrier record to date of 89 sorties in one day conducting attacking raids and targeting sorties for USS New Jersey. The Fleet Air Arm operated in a strike, ground support, and escort role during the deployment, which saw three RAN pilots killed and a fourth seriously wounded, while a total of fifteen aircraft were lost, including two Corsair S.1.

 

After just three years of service, starting in 1953 towards the end of the Korea crisis, all RAN Corsairs saw a major equipment update, including an AN/APS-4 radar which was added in a housing under the starboard wing. This simple radar could be used for radar navigation, radar beacon homing and radar bombing, as well as airborne target search, so that the Corsairs could even be employed as night fighters. The modified machines were re-designated SAW.1 ("Strike - All Weather").

 

All RAN Corsairs served exclusively with 806 Squadron alongside Hawker Sea Furies and later De Havilland See Venom all-weather fighters. After the Korean War the squadron was quickly relocated to HMAS Melbourne when HMAS Sydney was to be decommissioned in the late 50ies. The robust machines were withdrawn from carrier use in 1965 but remained in land-based service at Nowra Air Station until 1968, when the squadron was disbanded and the last machines retired. They were effectively replaced by A-4 Skyhawks.

  

General characteristics

• Crew: 1 pilot

• Length: 37 ft (11.09 m)

• Wingspan: 41 ft 0 in (12.5 m)

• Height: 17 ft 1 1/2 in (5.11 m)

• Empty weight: 9,205 lb (4,174 kg)

• Loaded weight: 14,670 lb (6,653 kg)

 

Powerplant:

• 1 × water-cooled V12 Rolls Royce Griffon RG.25.SM engine with 2.625 hp (1.955 kW)

 

Performance

• Maximum speed: 426 mph (350 kn, 688 km/h)

• Range: 900 mi (783 nmi, 1,450 km)

• Service ceiling: 41.500ft (12.649 m)

• Rate of climb: 3,870ft/min (19.7 m/s)

 

Armament:

4 × 20 mm (.79 in) Hispano Mk V cannons

4.000 pounds (1.800 kg) of external ordnance, including drop tanks, iron bombs of up to 1.000 lbs. calibre or up to 16× 3" (76.2 mm) rockets

  

The kit and its assembly:

Another whiffy 'science fiction' model. I found the idea of an après-WWII-Corsair in Commonwealth use interesting, since the type had a very long and successful career, and the 2012 “Aussierama” group build at whatifmodelers.com fuelled this project further.

 

Neither a RAN Corsair ever existed, nor a V12 engine variant, though. My initial idea was a Corsair with a Centaurus engine and a five-bladed propeller. But this is a rather common whif conversion, you find a lot of these – easy to do and it looks great, too. But I wanted "something more".

An early concept element was the bubble canopy with the lowered rear fuselage, but the Griffon entered the scene relatively late, just when I found a resin conversion set from Red Roo Models of Australia with RAAF Avro Lincoln engine nacelles. That engine would make the difference I had been looking for – and it was furthermore a nice ‘excuse’ for fitting a massive contraprop… ;)

 

The basis kit for this conversion is a French F4U-7 from Italeri. It is a very good kit which is still around in several permutations and re-boxings, e .g. from Revell o. G.. Wings, horizontal stabilizers and landing gear were taken OOB, but the fuselage saw heavy modification:

 

a) The resin Griffon from Red Roo was implanted just in front of the wing's leading edge. The fuselage was simply cut off and the former exhaust niches filled with putty. Easier than expected, even though tedious and time-consuming!

The Red Roo engines come without any props, so that the propeller is a donation part: it comes from a vintage Plasticart Tu-20/95 bomber in 1:100 scale. The blade tips were clipped for a modern look, matching the diameter of the original F4U propeller. Ground clearance would not be a problem, since the propeller sits higher on the fuselage than with the original radial engine.

 

b) The original round fin was completely replaced by a new horizontal stabilizer. This piece is the outer section of a vintage 1:100 scale An-12(!), also from Plasticart. As a side note: this donation part is probably 35 years old, but here it finally found a new and good use! It is a simple but very effective change – with the new fin the converted Corsair now looks a little like a Blackburn Firebrand or later Firecrest?

 

c) The complete upper fuselage was replaced by a lower, scratch-built/hand-welded polystyrene piece. It received a new cockpit opening and a scratch-built fairing for the new bubble canopy. The latter comes from a Hasegawa Vought XF5U-1 (the 'Flying Pancake') and makes the Corsair look pretty fast and streamlined. A pilot (Italeri?) was added to the cockpit, which was otherwise kept OOB since it is nicely detailed, just like the rest of the OOB kit.

 

I guess that only 50% of the original fuselage survived this major surgery! A wonder that the thing still holds together...

 

Further minor mods include the radar housing (leftover from another Italeri F4U kit), new guns in the wings and the unguided 3" missiles with launch rails instead of USN HVARs. They add IMHO much to the British look of the aircraft. The RPs come from a Matchbox Bristol Beaufighter, the racks, too, but the original, massive four-missile-pallets were separated into single launch rails, for a more delicate look.

The drop tank comes from the original kit, even though its centerline position is individual. The bomb hardpoints under the wing roots were retained, but left empty. You can IMHO easily ‘kill’ a whif plane with too much and/or too exotic ordnance, and there's already enough extra about this model to discover.

  

Painting and markings:

To make the plane a bit exotic (and for the aforementioned group build) I decided to build it in Australian Navy colors, with Kangaroo Roundels. Initially I wanted to place the RAN Corsair into the Korean War era, but at that time the Kangaroo roundels had not been in use yet (they were introduced in July 1956, after the war). On the downside of that time window, quick ID "invasion stripes" from the Korean War era would not be plausible anymore - and they'd only go together with RAF-style roundels, which I did not want to use since I wanted a clear identification of the Corsair's (fictional) user. Therefore, the model was placed in the late 50ies.

 

I kept the Corsair in typical RAN colors of that era, though. Sea Furies and Gannets were benchmarks, not only for the paint scheme but also for the markings/decals. Basic colors are Extra Dark Sea Grey (Humbrol 123) from above and Sky Type S (Testors 2049) from below, with a high waterline and with EDSG wrapped around the leading edges – a detail I copied from RAN Gannets.

 

As a little design twist I tried to make some areas look as if Korean War ID stripes on wings and fuselage had recently been painted over - and approprtaiet detail for 1957, and just after the RAAF/RAN introduced the Kangaroo Roundels. Therefore, upper sides of wings and fuselage were painted with Testors 2079 (RLM 66) and Humbrol 90 (Beige Green, actually Sky Type S, too, but with a kore yellow-ish hue than the Testors paint). I think it worked well, and makes the simple two-tone livery a bit more attractive?

 

Cockpit interior was painted in RAF Cockpit Green (Humbrol 78), the landing gear as well as its wells were left in aluminum (Humbrol 56).

 

The kit was only slightly weathered, with a very thin black ink wash, some dry painting with lighter shades of the basic tones in order to emphasize panel lines, and even less dry painting with silver on leading edges.

Additionally, some light exhaust and gun soot stains were added, simple dry painting with matt black and some dark grey.

 

The decals were puzzled together from several Xtracedal aftermarket sheets (for Fairey Gannets and Hawker Sea Furys) and the scrap box. In order to add a colorful contrast I decided to add some bold squadron colors on fin and spinner, since I have seen similar markings on RAN Gannets of that time. I went for black and yellow, as complementary colors to the red/white/blue roundels. The checkered rudder was cut from an aftermarket sheet for small-scale tabletop vehicles. The spinner was painted by hand.

 

Finally, everything was sealed under stain varnish (Tamiya), and a slightly sprayed some matt varnish onto the upper front areas, so that the paint looks a bit dull and worn without sacrificing the sheen look.

  

All in all, a major conversion with little problems – waiting for the resin parts from Australia to arrive was the biggest challenge. I think that the aircraft looks pretty plausible? A subtle whif. ^^

Just a sampling of the seemingly endless trips to the sushi bar by this Green Heron on Horsepen Bayou.

It is funny how we forget things we have done.

 

Below, I state that this was my first visit to the cathedral as a churchcrawler.

 

When I began to post shots, I looked for the album to put the shots in, only to find there wasn't one.

 

A search of my photostream showed two visits to the cathedral, complete with interior shots from 2013 and the previous years.

 

I had no memories of these visits.

 

What else have I forgotten?

 

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Norwich is a fine city. Or so the signs say on every road into it. But, and there can be no denying it, it is a jewel in the Norfolk countryside.

 

For me it is “just” Norwich Where used to go for our important shopping, for football and later for concerts. We, and I, would take for granted its cobbled streets, Norman cathedral and medieval churches by the dozen. Also it’s a pub for every day, the ramshackle market, and the Norman castle keep looking down on the city sprawled around.

 

Just Norwich.

 

Later, it also became where I bought new records from Backs in Swan Lane, and searched for punk classics in the Record and Tape Exchange.

 

Norwich is lucky that the industrial revolution passed by the city leaving few changes, the character and history intact. World War II did damage, some churches were abandoned, some rebuilt, but many survived.

 

And Norwich is a friendly city. It sees warm and colourful, and on a hot summer’s day when the locals were in shorts and t-shirts, much white flesh was on display. I also take the football club for granted. I have supported it from nearly 49 years, and being away from the city means I get my news and views largely second hand, but I also forget how central the club is to the people.

 

Sadly, Norwich isn't really on the way to anywhere, well except Great Yarmouth and Cromer, so people don't come here by accident. So it remains something of a secret to most but locals.

 

Other cities would have children dressed in any one of a dozen Premier League club’s replica shirts. In Norwich yellow and green was the dominant colour, even after a chastening season that saw us finish rock bottom of the league. The local sports “superstore” has a Norwich Fan’s fanzone, and a third of the window is given to the home city club.

 

I knew the city like the back of my hand, so knew the route I wanted to take to provide me with views that would refresh those in my mind. I didn’t dally, pressed on to my two targets, the Anglican Cathedral and St Peter Mancroft.

 

This wasn’t the original plan; that was to meet two friends I used to go to the football with, Ian and Ali, but they both caught a bug in Manchester watching the women’s Euros, so couldn’t meet with me. But I had an alternative plan, maybe with a pub stop or two.

 

The trip happened as I got a mail offering a tempting 20% off the trip that had been selling poorly, I checked with Ian and Alison, they said they were free, but had yet to fall ill. So seats were booked, as Jools liked the sound of an afternoon in Norwich and meeting my friends.

 

Up at quarter to five so we could catch the first High Speed service out of Dover, so to be in London in time to catch the railtour to Norwich.

 

Sun had yet to light up Dover Priory when we arrived, but a few people milling around, including two still at the end of their night out.

 

Folkestone was light by the warm light of the rising sun, and well worth a shot as we passed over Foord Viaduct.

 

Later, I was hoping the calm morning meant the Medway would be a mirror, but a breeze disturbed the surface ruining the reflections I had hoped for.

 

Finally, emerging into Essex, the line climbs as the go over the Dartford Crossing, just enough time to grab a shot.

 

It was already hot in London, so we stayed in the shade of the undercroft at St Pancras, had a coffee and a pasty from Greggs before walking over to Kings Cross to see if our tour was already at the buffers.

 

We walked across the road to King's Cross, and find the station packed with milling passengers, all eyes trained on the departure boards waiting for platform confirmations.

 

Ours was due to be platform 3, and the rake of carriages was indeed there, top and tailed by class 66 freight locomotives.

 

We get on the train and find we had been allocated a pair of seats nearest the vestibule. This meant that they were a few inches less wide than others, meaning Jools and I were jammed in.

 

Almost straight away, Jools's back and Achilles began to ache, and the thought of four hours of this in the morning and another four in the evening was too much, and so she decided to get off at the first stop at Potters Bar.

 

In the end, a wise choice I think.

 

The guy in the seat opposite to us talked the whole journey. I mean filling any silence with anything: how much he paid for the components of his lunch, his cameras and then his job. In great detail. He also collected train numbers. I didn't know that was really a thin in the days of EMUs, but I helped out from time to time telling him units he had missed.

 

We had a twenty minute break at Peterborough because of pathing issues, so we all got out to stretch our legs and do some extra trainspotting.

 

An Azuma left from the next platform, and another came in on the fast line. I snapped them both.

 

From Peterborough, the train reversed, and after the 20 minute wait, we went out of the station southwards, taking the line towards Ely.

 

Now that we had done our last stop, the train could open up and we cruised across the Fens at 70mph, the flat landscape botted with wind turbines and church towers slipped by.

 

Instead of going into Ely station, we took the rarely used (for passenger trains) freight avoiding line, now a single track. Emerging crossing the main line, taking the line eastwards towards Thetford.

 

Again, the regulator was opened, and we rattled along. Even so, the journey was entering its fourth hour, and with my travelling colleague and without Jools, time was dragging.

 

We were now back in Norfolk, passing the STANTA training area, all warning signs on the fences telling the trainee soldiers that that was where the area ended. I saw no soldiers or tanks. My only thought was of the rare flowers that would be growing there, unseen.

 

And so for the final run into Norwich, familiar countryside now.

 

Under the southern bypass and the main line from London, slowing down where the two lines merged at Trowse before crossing the River Wensum, before the final bend into Norwich Thorpe.

 

At last I could get off the train and stretch my legs.

 

Many others were also getting off to board coaches to take them to Wroxham for a cruise on the Broads, or a ride on the Bure Valley Railway, while the rest would head to Yarmouth for four hours at the seaside.

  

I got off the train and walked through the station, out into the forecourt and over the main road, so I could walk down Riverside Road to the Bishop’s Bridge, then from there into the Cathedral Close.

 

The hustle and bustle of the station and roadworks were soon left behind, as the only noise was from a family messing about in a rowing boat in front of Pulls Ferry and a swan chasing an Egyptian Goose, so the occasional splash of water.

 

I reached the bridge and passed by the first pub, with already many folks sitting out in the beer garden, sipping wines and/or summer beers. I was already hot and would loved to have joined them, but I was on a mission.

 

In the meantime, Jools had texted me and said if I fancied getting a regular service back home, then I should. And a seed grew in my brain. Because, on the way back, departing at just gone five, the tour had to have a 50 minute layover in a goods siding at Peterborough, and would not get back to Kings Cross until half nine, and then I had to get back to Dover.

 

I could go to the cathedral the church, walk back to the station. Or get a taxi, and get a train back to London at four and still be home by eight.

 

Yes.

 

I walked past the Great Hospital, then into the Close via the swing gate, round to the entrance where there was no charge for entry and now no charge for photography. But I would make a donation, I said. And I did, a tenner.

 

I have been to the cathedral a few times, but not as a churchcrawler. So, I made my way round, taking shots, drinking in the details. But the walk up had got me hot and bothered, I always run with a hot engine, but in summer it can be pretty damp. I struggled to keep my glasses on my nose, and as I went round I knew I was in no mood to go round again with the wide angle, that could wait for another visit.

 

The church is pretty much as built by the Normans, roof excepted which has been replaced at least twice, but is poetry in stone. And for a cathedral, not many people around also enjoying the building and its history.

 

At one, bells chimed, and I think The Lord’s Prayer was read out, we were asked to be quiet. I always am when snapping.

 

In half an hour I was done, so walked out through the west door, through the gate and into Tombland. I was heading for the Market and St Peter which site on the opposite side to the Guildhall.

 

I powered on, ignoring how warm I felt, in fact not that warm at all. The heat and sweats would come when I stopped, I found out.

 

I walk up the side of the market and into the church, and into the middle of an organ recital.

 

Should I turn round and do something else, or should I stop and listen. I stopped and listened.

 

Everyone should hear an organ recital in a large church. There is nothing quite like it. The organ can make the most beautiful sounds, but at the same time, the bass pipes making noises so deep you can only feel it in your bones.

 

Tony Pinel knew his way round the organ, and via a video link we could see his hands and feet making the noises we could hear. It was wonderful, but quite how someone can play one tune with their feet and another with their hands, and pulling and pushing knobs and stoppers, is beyond me. But glad some people can.

 

It finished at quarter to two, and I photograph the font canopy and the 15th century glass in the south chapel. Font canopies are rare, there is only four in England, and one of the others is in Trunch 20 miles to the north. Much is a restoration, but it is an impressive sight when paired with the seven-sacrament font under it.

 

The glass is no-less spectacular, panels three feet by two, five wide and stretching to the vaulted roof. I can’t photograph them all, but I do over 50%.

 

I go to the market for a lunch of chips, for old times sake. I mean that was the treat whenever we went either to Norwich or Yarmouth; chips on the market. I was told they no longer did battered sausage, so had an un-battered one, and a can of pop. I stood and ate in the alleyway between stalls, people passing by and people buying chips and mushy peas of their own.

 

Once done, I had thought of getting a taxi back to the station, but the rank that has always been rammed with black cabs was empty, and two couples were shouting at each other as to who should have the one that was there. So I walked to the station, across Gentleman’s Walk, along to Back of the Inns, then up London Street to the top of Prince of Wales Road and then an easy time to the station across the bridge.

 

I got my ticket and saw a train to Liverpool Street was due to depart at 14:32. In three minutes.

 

I went through the barrier and got on the train, it was almost empty in the new, swish electric inter-city unit. I was sweating buckets, and needed a drink, but there appeared to be no buffet, instead just electric efficiency and silence as the train slid out of the station and went round past the football ground to the river, then taking the main line south.

 

In front of me, two oriental ladies talked for the whole journey. I listened to them, no idea what they talked about to fill 105 minutes.

 

I thought it would be nearly five when the train got in, but helped by only stopping at Diss, Ipswich, Manningtree and Colchester we got in, on time, at quarter past four.

 

I walked to the main concourse and down into the Circle Line platforms, getting a train in a couple of minutes the four stops to St Pancras. I knew there was a train soon leaving, and after checking the board and my watch I saw I had five minutes to get along the length of the station and up to the Southeastern platforms.

 

I tried. I did, but I reached the steps up to the platforms and I saw I had 45 seconds, no time to go up as they would have locked the doors. So, instead I went to the nearby pub and had a large, ice-cold bottle of Weiss beer.

 

That was better.

 

I was all hot and bothered again, but would have an hour to cool down, and the beer helped.

 

At ten past five, I went up and found the Dover train already in, I went through the barriers and took a seat in a carriage I thought would stop near the exit at Dover Priory. I called Jools to let her know I would be back at quarter to seven, and she confirmed she would pick me up.

 

She was there, people got off all out on a night on the town, dressed in shiny random pieces of fabric covering boobs and bottoms. I was young once, I thought.

 

Jools was there, she started the car and drove us home via Jubilee Way. Across the Channel France was a clear as anything, and four ferries were plying between the two shores. Take us home.

 

Once home, Jools had prepared Caprese. I sliced some bread and poured wine. On the wireless, Craig spun funk and soul. We ate.

 

Tired.

 

It was going to be a hot night, but I was tired enough to sleep through it. Or so I thought.

  

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Norwich has everything. Thus, the normally dry and undemonstrative Nikolaus Pevsner began his survey of the capital of Norfolk in his 1962 volume Buildings of England: Norwich and north-east Norfolk. And there is no doubt that this is one of the best cities of its size in northern Europe. Living in Ipswich as I do, I hear plenty of grumbles about Norwich; but really, although the two places have roughly the same population, Ipswich cannot even begin to compare with regard to its townscape. The only features which the capital of Suffolk can claim to hold above its beautiful northern neighbour are a large central park (Norwich's Chapelfield gardens is not a patch on Ipswich's Christchurch Park) and a large body of water in the heart of the town, perhaps Ipswich's most endearing feature and greatest saving grace.

But Norwich has everything else - to continue Pevsner's eulogy, a cathedral, a castle on a mound right in the middle, walls and towers, a medieval centre with winding streets and alleys, thirty-five medieval parish churches and a river with steamships. It even has hills...

 

I think it would be possible to visit Norwich and not even know this cathedral was there. The centre of the city is dominated by the castle, and the most familiar feature to visitors is the great market square widened by the clearances of the 1930s, and the fine City Hall built at that time which towers above it. In comparison, Norwich Cathedral sits down in a dip beside the river, walled in by its close, and is visible best from outside the city walls, especially from the east on the riverside, and to the north from Mousehold Heath. If you arrive by road from the south or west, you may not even catch a glimpse of it. The great spire is hidden by those winding streets and alleys, and many of the city's churches are more visible, especially St Giles, St Peter Mancroft in the Market Place, and the vast Catholic Cathedral of St John the Baptist, on Grapes Hill. It is said that the nave floor of St John the Baptist is at the same height above sea level as the top of the crossing of the Anglican cathedral.

 

With the possible exception of Lincoln Cathedral, I think that Norwich Cathedral is my favourite cathedral in all England. Call this East of England chauvinism if you like, But Norwich Cathedral has everything you could possible want from a great medieval building. But there is more to it than that. It is also one of the most welcoming cathedrals in England. There is no charge for admission, and they positively encourage you to wander around through the daily business of the cathedral, in the continental manner. No boards saying Silence Please - Service in Progress here. Because of this, the Cathedral becomes an act of witness in itself, and you step into what feels like it probably really is the house of God on Earth. They even used to say the Lord's Prayer over the PA system once an hour, and invite you to stop and join in - I wish they'd go back to doing that. The three pounds you pay for a photography permit must be one of the bargains of the century so far.

 

Norwich Cathedral is unusual, in that this is the original building. It has been augmented over the centuries of course, but this is still essentially the very first cathedral on this site. This is because the see was only moved to Norwich after the Norman invasion. The Normans saw the wisdom of drawing together ecclesiastical and civil power, and one way in which this might be achieved was by siting the cathedrals in the hearts of important towns. At the time of the conquest, Bishop Herfast had his seat at Thetford, and it was decided to move the see to Bury St Edmunds in Suffolk. It had moved several times during the previous four centuries, from Walton in Suffolk to North Elmham in Norfolk before Thetford, where the first proper but simple stone building had been raised. But as well as an eye for efficient administration, the Normans brought the idea that Cathedrals should be glorified; already, vast edifices were being raised in Durham, London and Ely. and Bury St Edmunds, with its famous Abbey, was the obvious place for the Diocese of East Anglia to sit.

 

However, such a move would have removed the Abbey's independent direct line with Rome, and placed it under the jurisdiction of the Province of Canterbury. The Abbey community was determined that this would not happen, and Abbot Baldwin sent representations to the Pope that ensured the survival of St Edmundsbury Abbey's independence. Bishop Herfast would not be allowed to glorify his position in East Anglia in the way his colleagues were doing elsewhere. But his successor, Herbert de Losinga, was more determined - and, perhaps, steeled by his conscience. A Norman, he had bought the Bishopric from the King in 1091, an act of simony that required penance. Building a great cathedral could be seen as that act of penance. But where? Bury was a lost cause; instead, he chose to move the see to a thriving market town in the north-east of his Diocese; a smaller, more remote place than Bury, to be sure, but proximity to the Abbey of St Edmund was perhaps not such a good thing anyway. It tended to cast a rather heavy shadow. And so it was that the great medieval cathedral of the East Anglian bishops came to be built, instead, at Norwich.

 

Work began in 1094, and seems to have been complete by 1145. It is one of the great Romanesque buildings of northern Europe, its special character a result of responses to fires and collapses over the course of the next few centuries. At the Reformation in the sixteenth century, it became a protestant cathedral of the new Church of England, losing its role as a setting for ancient sacraments and devotions, but being maintained as the administrative seat of a Diocese which covered all of Norfolk and Suffolk, and the ceremonial church of its great city. In the 19th Century, the western part of the Norwich Diocese was transferred into that of Ely, and at the start of the 20th Century the southern parishes became part of the new Diocese of St Edmundsbury and Ipswich. Today, the Diocese of Norwich consists of north, south and east Norfolk, and the north-eastern tip of Suffolk.

 

The absence of this great church from the Norfolk Churches site has long been the elephant in the room, so to speak. And having it here at last is, I feel, a mark of how things have changed. When I first started the Norfolk and Suffolk sites back in 1999, I did not have a decent camera, and the earliest entries did not have any photographs at all. How the wheel has turned. Now, the photographs have become the sites, and with no apologies I don't intend to make this a wordy entry.

 

The perfection of Norwich is of distant views, the cloisters, and the interior. The exterior is hemmed in, and the most familiar part of the building, the west front, is a poor thing, the victim of barbarous restorations in the 18th and 19th centuries. It is almost a surprise to step through its mundanity into the soaring glory of the nave. Above, the famous vaulting is home to one of the largest collections of medieval bosses in the world. There are more in the beautiful cloisters.

 

The view to the east is of the great organ, looking very 17th Century but actually the work of Stephen Dykes Bower in the 1950s. Beyond is the intimacy of the quire and ambulatory with its radial chapels, the best of which is St Luke's chapel, containing the Despenser retable. Bishop Despenser is one of history's villains, putting down the Peasants Revolt in East Anglia with some enthusiasm. It is likely that this retable was made for the cathedral's high altar, possibly even to give thanks for the end of the Revolt. It was discovered upside down in use as a table in the 1840s. This chapel is, unusually, also a parish church; the parish of St Mary in the Marsh, the church of which was demolished at the Reformation, moved into the cathedral. They brought their seven sacrament font with them, and here it remains.

 

In the ambulatory there are many traces of medieval paint, almost certainly from the original building of the Cathedral. Two curiosities: at the back of the apse is the original Bishop's chair, and rising across the north side of the ambulatory like a bridge is a relic screen.

 

There is a good range of glass dating from the 14th to the 21st centuries. Highlights include the medieval panels in the north side of the ambulatory, Edward Burne-Jones's bold figures in the north transept, Moira Forsyth's spectacular Benedictine window of 1964 in a south chapel, and the millennium glass high in the north transept, which I think will in time become one of the defining features of the Cathedral. The figure of the Blessed Virgin with the Christ Child seated on her lap is the work of Norfolk-based artist John Hayward, who died recently, but the glass above is Hayward's reworking of Keith New's 1960s glass for St Stephen Walbrook in London, removed from there in the 1980s, and now reset here. Towards the west end of the nave are two sets of Stuart royal arms in glass, a rare survival.

 

I grew up in a city some sixty miles away from Norwich, but I didn't come here until I was in my mid-teens. I remember wandering around this building and being blown away by it, and I still get that feeling today. There is always something new to find here. My favourite time here is first thing in the morning on a winter Saturday. Often, I can be the only visitor, which only increases the awe. Another time I like to be here in winter is on a Saturday afternoon for choral evensong. Perhaps best of all, though, is to wander and wonder in the cloisters on a bright sunny day, gazing at fabulous bosses almost within arm's reach.

Several English cathedrals have good closes, but Norwich's is the only one in a major city, I think. It creates the sense of an ecclesiastical village at the heart of the city; and then, beyond, the lanes and alleys spread out, still hanging on despite German bombing and asinine redevelopment. And now I think perhaps it is part of the beauty of this building that it is tucked away by the river, a place to seek out and explore. Norwich has everything, says Pevsner. But really, I think this is the very best thing of all.

 

www.norfolkchurches.co.uk/norwichcathedral/norwichcathedr...

Finally managed to bribe some of my clones to help out around here.

 

Entry for April's Scavenger Hunt

Created for a Cirque de Soleil installation and fundraiser for energy efficiency.

The dolls are 30 inches tall and made with Cernit and Aves. They will be suspended, like acrobats, in the air.

 

www.strangedolls.net

On Wednesday, I realized I still had trip photos on a roll of film in my Holga and decided to finish it off on the way down to the lab.

 

This is the first stop on the way, the corner of Lansdowne & St Clair, where the 47 Lansdowne bus picks up passengers. If only it was that simple though. This stop is also the worst example of TTC efficiency I've ever known... and has been for years.

 

The problem here is that you have the 47 bus and the 47B/C. The 47 comes up from Queen and goes into the loop at St Clair. The 47B/C continues north to Yorkdale, bypassing the loop. If you are waiting at St Clair to head south, both busses will pass the streetside stop on their identical way down, BUT the 47 will not pick up passengers on the street. You have to get on it in the loop - a half block over. If you are at the street stop it will keep its doors shut, no matter how hard you knock at the door.

 

Commuters not from this area always get left behind. Locals who understand the ridiculous setup have developed a silent system whereby we wait ALL OVER THE STREET. As you can see in the pic, some people are waiting by me -- at the stop, while some with kids are hovering in the middle of the block, and others, like the lady in the white hooded coat are even futher along, looking into the loop. If I see the bus, I'll walk up the curb and those near the loop will see me and run over. If I see the loop people head into the loop, I'll run over there (and watch for that ice, eh). Today, the loop driver blazed through the loop making no stop and then pulled over on the street, let us in, lecturing everyone that he isn't really supposed to stop here but is being 'nice'.

 

Thankfully, there are a few 'nice' drivers... I'm thinking it's more that they just have some kind of heart. The early morning bastard who leaves all the little old ladies freezing in his dust because they can't run between stops... well, he can't possibly last long, 'cause you know they are all just throwing him their meanest evil eye... and I'll bet those things can add up over the course of a career, y'know?

  

originally posted to: www.doublecrossed.ca/index.php?showimage=1058

I've been a little obsessed with pin-ups and classic love stories this week, so I made this. Painted board, vintage text (c. 1960), silhouette and woman with curlers painted in acrylics, 8" by 10". I'm considering making a series and selling them online.

To Make Your Brain More Efficient, Try New Things…

Your Brain Becomes Stimulated Once You Experience New Things.

From: boundless.uoregon.edu/cgi-bin/showfile.exe?CISOROOT=/arch...(visual%20works)%22

 

"Portland's Municipal A Self- Guided Tour

 

The Portland Water Bureau strives to deliver the highest quality drinking water and service to the Portland community while also being conscientious stewards of the city's natural, fiscal and structural resources. For more information about the Portland Water Bureau, visit: www. portlandonline. com/ water • 503- 823- 7770 For information about Portland's public art, please contact the Regional Arts & Culture Council: www. racc. org • 503- 823- 5111 For more information on Portland's municipal fountains, visit: www. portlandonline. com/ water/ fountains Efficiency Most of Portland's decorative fountains recirculate water to minimize water use and run- off. The bureau has installed meters to gauge water use and electrical consumption. Health and Safety The health and safety of Portland's fountains, especially its interactive fountains, is a top priority for the Portland Water Bureau. The bureau cleans fountains regularly, monitors operations and chlorinates the interactive fountains to the level of a swimming pool.

 

P o r t l and' s M u n i c i pa l F o u n ta i n s

 

The Portland Water Bureau has proudly maintained Portland's municipal decorative fountains since 1988. The Water Bureau maintains beautiful fountains throughout the Portland area and the largest concentration of them lies within the downtown area. Take this opportunity to discover and explore downtown Portland and her treasure chest of unique artwork — Portland's fountains. Unlock their secrets and ponder their history as you wind your way through this bustling area of the city on a 2.6- mile, self- guided tour. Maintenance Maintaining these fountains is no small feat.

 

The Portland Water Bureau employs one full- time "Fountain Man" who spends his days ensuring that Portland's fountains are in working order, safe for public enjoyment and running efficiently. The bureau turns the fountains off for the cold weather months to prevent water from blowing or freezing on surfaces. This "down time" also provides an opportunity for maintenance and repair projects.

 

Portland's Interactive Fountains:

 

• Salmon Street Springs Fountain

Gov. Tom McCall Waterfront Park

 

• McCoy Fountain

N. Trenton Street & Newman Avenue

 

• Holladay Park Fountain

NE 11th Avenue & Multnomah Street

 

• Jamison Square Fountain

810 NW 11th Avenue

 

Fountain enthusiasts should be aware that the water in these fountains is not suitable for drinking. Also, please use caution when walking near pools of water or on slippery surfaces. Aesthetics The Portland Water Bureau works with the Regional Arts & Culture Council to maintain aesthetics at each fountain. Sculptures undergo restoration when needed, in order to present the art as originally intended. For more information on Portland's municipal fountains visit www. portlandonline. com/ water/ fountains

 

Other fountains maintained by the Portland Water Bureau:

 

• A Fountain for a Rose (O' Bryant Square Fountain) SW Park Avenue & Washington Street

 

• Holladay Park Fountain NE 11th Avenue & Multnomah Street

 

• The Rose Petal SE 106th Avenue & Stark Street

 

• McCoy Fountain N. Trenton Street & Newman Avenue

 

The City of Portland will make reasonable accommodation for people with disabilities. Please notify us no less than five ( 5) business days prior to the event by phone at 503- 823- 7404, by the city's TTY at 503- 823- 6868, or by the Oregon Relay Service at 1- 800- 735- 2900. Printed on recycled paper 03/ 2009 Portland Water Bureau 1120 SW 5th Avenue, Room 600 Portland, OR 97204- 1926 Phone: 503- 823- 7404 Customer Service: 503- 823- 7770 Web site: portlandonline. com/ water Randy Leonard, Commissioner David G. Shaff, Administrator Fountains Ira Keller Forecourt Fountain Dreamer Fountain Salmon Street Springs Fountain Shemanski Fountain or " Rebecca at the Well" Lovejoy Fountain Animals in Pools Fountains Jamison Square Fountain The Jamison Square Fountain is the centerpiece of Northwest Portland's Jamison Square. Named in honor of William Jamison, an early advocate and catalyst for the development of the Pearl District, the fountain's wading pool offers cooling relief on hot summer days. Water cascades from stone joints into shallow pools where it ebbs and flows like the tide. Washington Stark Oak Pine Alder Morrison Yamhill Taylor Salmon Main Madison Jefferson Columbia Mill Harrison College Hall 9th Park Broadway 6th 5th 4th 3rd 2nd 1st SW Naito Parkway Ash Clay 10th 11th Montgomery Market Jackson Ankeny Lincoln 12th Burnside Walk up the stairs to reach Burnside Burnside Bridge Morrison Bridge Hawthorne Bridge Gov. Tom McCall Waterfront Park Willamette River 8 7 6 5 4 Streetcar or MAX stop Walking Tour Streetcar or MAX Line 12 10 1 2 2 3 11 9 LOOK BUT DON'T DRINK The water in the decorative fountains is not for drinking. Please use designated crosswalks when possible. Total Tour Length: 2.6 miles Total Tour Time: 2 hours Por t l and Fou n ta i n s Wa l k i n g To u r 1. Pioneer Courthouse Square Fountain SW Broadway Avenue & Yamhill Street 1983 • Will Martin In 1849, Elijah Hill bought this block of downtown Portland for $ 24 and a pair of boots. The site of Portland's first schoolhouse, Pioneer Courthouse Square is now the most visited attraction in Portland. The fountain, which features imported tile, is a major part of Portland's " living room." Look for designer Will Martin's bronze hat at the top of the fountain. 2. Animals in Pools Fountains SW Yamhill & Morrison streets between 5th & 6th avenues 1986 • Georgia Gerber • bronze, concrete Eleven " pools" feature sculptures of animals native to Oregon. Sea lions, beavers, bears, river otters, ducks and deer line Morrison and Yamhill streets. Sculptor Georgia Gerber wanted to offer " a sense of the wild in the midst of a busy city." In 1991, one of the beloved bear cubs was stolen, but public outcry led to an anonymous tip that the cub was hiding in the bushes in neighboring Washington County. 3. Shemanski Fountain ( Rebecca at the Well) Park Blocks between SW Salmon & Main streets 1926 • Oliver Barrett ( stone) and Carl Linde ( bronze) Joseph Shemanski, the fountain's namesake, was a Polish immigrant who began his career selling clocks on an installment plan; he eventually owned 34 Pacific Coast stores of the Eastern Outfitting Company. Shemanski commissioned this fountain as a gesture of appreciation for the people of Portland who had so warmly welcomed him. His compassion for animals inspired the three pet- level drinking fountains. There are also three human- level fountains. Two years after the initial fountain was erected, Shemanski commissioned the sculpture of Rebecca at the Well, which reflects the biblical tale of Abraham's discovery of a bride for Isaac when he saw Rebecca drawing water for camels. Abraham chose Rebecca for Issac because of her kindness and service. 4. Chimney Fountain North of SW Lincoln Street between 3rd & 4th avenues 1968 • brick The southernmost of downtown fountains, this small structure was erected as part of the South Auditorium Project, the Portland Development Commission's first urban renewal project. The Chimney Fountain gives the illusion that water is flowing between the bricks, as smoke might seep through a chimney. 5. Lovejoy Fountain SW 3rd Avenue, between Lincoln & Harrison streets 1968 • Lawrence Halprin • concrete, brick In an 1843 contest with Francis Pettygrove, Asa Lovejoy, this fountain's namesake, lost two out of three coin tosses and thus the right to name our city after his hometown of Boston. Lovejoy and Pettygrove flipped the coin a second time to determine which of two neighboring parks would be named Lovejoy and which would be named Pettygrove. This beautiful fountain was built in Lovejoy's park and took on his name. With conservation in mind, the Portland Water Bureau fitted the Lovejoy Fountain with a more efficient water pump in 2008. Before installation of the new pump, the fountain took 12 hours to fill. 6. Dreamer Fountain SW 3rd Avenue between Market & Harrison streets 1979 Manuel Izquierdo • Muntz bronze Located in Pettygrove Park, Manuel Izquierdo's design of a reclining woman is made from surplus navy bronze that he bought and cleaned. Izquierdo said, " The Dreamer speaks of hope, of beauty and serenity, of love, and for a better life in our midst." Izquierdo filled the sculpture with foam so that falling rain would make a gentle sound like a kettledrum instead of ringing hollow. Izquierdo is professor emeritus at the Pacific Northwest College of Art. 7. Ira Keller Forecourt Fountain SW 3rd & 4th avenues between Market & Clay streets 1971 • Angela Danadjieva Designed to mimic the majestic waterfalls of Oregon's Cascade Mountains, the Ira Keller Fountain is truly one of Portland's best known landmarks. Formerly named, simply, Forecourt Fountain, it was renamed in 1978 in honor of the first chairman of the Portland Development Commission, Ira Keller, who had a major influence on the rehabilitation of the area. Residents and visitors alike flock to this series of waterfalls and pools which occupy nearly a full acre in downtown Portland's busiest business district. New York Times critic Ada Louise Huxtable declared this " one of the most important urban spaces since the Renaissance." 8. Elk Fountain SW Main between 3rd & 4th avenues 1900 • Roland Perry ( bronze) and H. G. Wright ( stone) Inspired by the Skidmore Fountain, former mayor David Thompson, president of the Oregon Humane Society, donated the money for this fountain as a trough for horses and dogs, and as a reminder of the elk that once lived in the West Hills and used the neighborhood as a feeding ground. Shortly after the statue was erected, a local artist offered to wire the antlers with electric light bulbs for $ 30. The offer was declined. 9. Salmon Street Springs Fountain SW Salmon Street at Gov. Tom McCall Waterfront Park 1978 • Robert Perron • concrete The Salmon Street Springs Fountain is one of Portland's most iconic fountains, majestically spouting water in an array of designs and speeds. A computer changes the pattern of the water display every 20 minutes. At full capacity the fountain recycles 4,924 gallons of water per minute through as many as 137 jets at one time. Taking its name from the winner of a city- wide naming contest, the fountain has become one of Portland's most popular summer hangouts. A large gathering at this fountain's 20- Year Anniversary Celebration in spring 2008, proved that Salmon Street Springs is more popular than ever. Citizens turned out en masse to celebrate its presence, despite rainy conditions and cool temperatures. 10. Skidmore Fountain SW 1st Avenue between W. Burnside & Ankeny streets 1888 • Olin Warner • bronze, granite This fountain, Portland's oldest commissioned public art, stands at what was once the city center. Druggist Stephen Skidmore left $ 5,000 in his will so that " horses, men, and dogs" could have a cold drink. The fountain was sculpted by Olin Warner who modeled the face of his wife on one of the two caryatids. New York critics lamented that the sculpture was in Portland and that it looked down " upon buggies and buck- boards, and shirt- sleeves and slouch hats in Oregon instead of decorating the Central Park." Skidmore Fountain is inscribed with the quote, " Good citizens are the riches of a city" a line from the dedicatory speech by C. E. S. Wood, an attorney and member of the Fountain Committee. For the dedication, brewer Henry Weinhard offered to pipe beer through the fountain, but the chairman of the Fountain Committee declined. For nearly two decades, people drank water from tin cups that hung from the lion's heads on the fountain. 12. Lee Kelly's Fountain SW 6th Avenue & Pine Street 1977 • Lee Kelly • stainless steel Oregon artist Lee Kelly won an international competition to design this sculpture. Kelly has designed several other sculptures in Portland and throughout the Pacific Northwest. In this work, water flows over several 20- foot- tall steel structures. In conjunction with the Regional Arts & Culture Council, the Water Bureau helped to restore Kelly's fountain in 2004. The fountain had become run- down over the years. Opt i o n a l Tour E x t e n s i o n : 13. Jamison Square Fountain 810 NW 11th Avenue ( Jamison Square) • 2002 If you're feeling extra energetic, head over to Jamison Square Fountain. Just across West Burnside and into the Pearl District, Jamison has quickly become one of the city's most popular hot- weather hot spots. Poised as the centerpiece of Jamison Square, the fountain's wading pool offers cool relief to kids, dogs and adults all summer long. It was named in honor of William Jamison, an early advocate of Pearl District development. Somewhat like Oregon's coast, water cascades into shallow pools where it ebbs and flows like the tide. 11. Car Wash Fountain SW 5th Avenue & Ankeny Street 1977 • Carter, Hull, Nishita, McCulley & Baxter • steel This uniquely shaped fountain never washed cars, but the name seems appropriate given its similarity to a car wash. As a precaution for passing pedestrians, a wind gauge shuts off the pumps if the wind speed exceeds 2 miles per hour. For more information on Portland's municipal fountains visit: www. portlandonline. com/ water/ fountains"

Tomatoes harvested at a greenhouse in Armenia.

 

The High-Efficiency Horticulture and Integrated Supply Chain Project will support the development of 30 hectares of climate-controlled greenhouses equipped with drip irrigation systems in Yerevan to produce tomatoes and bell peppers.

 

Read more on:

Armenia

Agriculture and food security

High-Efficiency Horticulture and Integrated Supply Chain Project

The High-Efficiency Horticulture and Integrated Supply Chain Project will support the development of 30 hectares of climate-controlled greenhouses equipped with drip irrigation systems in Yerevan to produce tomatoes and bell peppers.

 

Read more on:

Armenia

Agriculture and food security

High-Efficiency Horticulture and Integrated Supply Chain Project

Dave Clanton's CPO crate engine resto-mod proposal: the performance and efficiency of modern crate motors and transmissions coupled with the significantly lighter weight of cars from the 1970s and 80s could yield >30-60 MPG with an exhilarating driving experience. Subcompacts to full size cars have increased by 900-1,500 lbs because of government mandated changes and consumer demand for larger vehicles when gas prices were low. An automaker could capitalize on this revolutionary opportunity three-fold. First, increase sales of new cars by offering substantial trade-in values comparable to those offered in the Cash for Clunkers US Govt program of about $4,000 per qualifying makes/models targeting cars with solid bodies and frames regardless of engine condition. Secondly, recondition the trade-ins with new crate motors and transmissions while also restoring the rest of the car to a Certified Pre-Owned (CPO) condition and sell them with full power train warranties and long term financing. Thirdly, this restoration and crate engine installation would gainfully employ service departments at dealers across the nation. Modern four cylinder and V8 engine swap designs already exist for dozens of domestic and import makes/models. The appeal of retro styling amongst buyers of all ages is evident by new car sales of Mini, Beetle, Mustang, Camaro, Challenger, Charger, Fiat 500, etc. Lastly, in regards to the all important environmental impact it would reduce CO2 emissions by replacing gross polluter power trains with modern modern EPA compliant power trains.

- Example of optimum efficiency would be a 1978-80 Ford Fiesta which weighs 1,576 lbs with a crate motor 2.0L direct injection 4-cyl from a 2011 Ford Focus which weighs 2,500 lbs. The heavier 2011 has an EPA rating of 28 MPG city/40 MPG hwy. The nearly 1,000 lb lighter 78-80 Fiesta could likely achieve 50-60 MPG with a modern drive train while also appealing to buyers with much greater acceleration.

- Example of efficient performance would be a 1974-78 Ford Mustang II which weighs 2,600 lbs with a crate motor 412 HP aluminum 302 Coyote V8 or a 305 HP 3.7L Duratec V6 from a 2011 Ford Mustang which weighs 5,500 lbs. The heavier 2011 Mustang V6 has an EPA rating of 19 MPG city/31 MPG hwy. The nearly 900 lb lighter 74-78 Mustang II could likely achieve 30-40 MPG with a modern drive train while also appealing to buyers with much greater acceleration.

- Dozens of qualifying makes/models include: 61-00 Mini and Clubman, 78-80 Ford Fiesta, 73-79 Civic, 74-78 Mustang II, 79-93 Fox-body Mustang/Capri, 71-80 Pinto, 70-77 Maverick, hot rods e.g. 32 Ford, kit cars e.g. Cobra, GT40, and Sebring, vintage pickup truck e.g. 75 Ford F150, 59-68 Sunbeam Alpine and 64-67 Sunbeam Tiger, 78-88 Zimmer, 90-97 Mazda Miata, 62-80 MG MGB, 74-00 Volvos e.g. 200, 700, 850, and S70/V70 series, 84-96 Mercedes W124, 70-81 F-body Camaro/Firebird, 82-92 F-body Camaro/Firebird, 74-82 C3 Corvette Stingray, 82-88 G-platform Regal, Cutlass, Grand Prix, Monte Carlo, 09-10 Kappa-platform Pontiac Solstice/Saturn Sky, 94-04 Aston Martin DB7, Porsche 911 and 914, 68-94 Jaguar XJ and other vintage Jags e.g. Mark IX, 82-94 BMW E30, 59-69 Chevrolet Corvair, 71-77 Chevy Vega, 70-78 Datsun 240Z, 260Z, and 280Z, 79-91 Mazda RX7, 75-81 Triumph TR7 and TR8, 75-80 AMC Pacer, 70-78 AMG Gremlin.

 

The New Trakker offers innovative solutions that improve efficiency and reduce fuel consumption and environmental impact. Discover the app and download it in Apple App Store or in Google Play Store!

 

Just a sample of modular origami surface area efficiency comparisons that I do. This analysis I do on some modulars that result in a completed closed surface to get an idea of how much paper was "wasted" in making locks and getting the right shapes for the particular polyhedron.

 

The black areas are the portions of each sheet of paper that becomes a part of the surface of the finished model (drawn perfectly to scale). The percents were calculated with a little help from AutoCAD.

 

As you can see, the sonobe unit is pretty inefficient. Though it should be noted that it sacrifices this efficiency for simplicity and flexibility. The other two are models of mine with both pictures and diagrams in my photostream. They were specifically designed for one polyhedron each, so in the customization allows them to gains efficiency.

 

Although 26%, or about 1/4 (for the dodecadodeca), might not sound very efficient, the drastically increased complexity of the shape it produces, including points of negative curvature, makes this design pretty efficient for what it does IMO; considering that it's twice as efficient as the sonobe unit.

 

The Icositetrahedron is one of my most efficient designs. The final model made from 24 sheets of paper is almost TWICE the diameter of a 30-piece sonobe model made from the same sized paper.

 

A simple example of a modular with even MORE efficiency is the Butterfly Ball, which sacrifices integrity for a 50% efficiency. This model doesn't even really have a lock; it is held together by friction. In fact, technically the sonobe unit is ALSO held together purely by friction, but at least the sonobe unit has pockets instead of just overlapping paper. Both of my designs shown here have strong, mechanical locks not based around friction.

___________________________

 

Surface area efficiency for my truncated rhombic triacontahedron (not shown here) is 30.9%, which I think is pretty good considering the super-strength of the locking mechanism.

 

Diagrams for all 3 of my models described here, the two in this photo as well as the one I just mentioned can be found in my "Diagrams & Notes" set. Photos of the completed models are in my "Origami Modulars" set.

The combination of increasingly complex high-risk financial instruments (unknown, under-acknowledged, under-estimated and/or misunderstood by public and private policy sector workers at all levels of governance) and a thriving culture of testosterone-driven traders with their hands firmly on the throttle of oil-dependent muscle vehicles, flooring-it on shared virtual highways with silently condoned (albeit) unwritten permission and even enthusiastic encouragement to exceed safe speed limits, the exponential growth in wealth of the upper quintile of the upper quintile accompanied by the exponential increase in poverty of the lower quintile of the lower quintile, the global expansion and implementation of the belief-system based on unfettered, self-regulated market political economies (loosely called market liberalism although best-served by political conservatism) promulgated around the planet through mass media content packaged to sell imagery of the invisible hand of the market as the right hand of the new secular god surrounded by soldiers of the user-pay, private-is-better, blame-the-poor, monetize-everything, blame-the-ill, social-justice-vs-economic-efficiency, base-minumum-wage-on-pin-money-workers, minimum-government, trickle-down-affect, legal-but-not-ethical, group-think-culture led by the Triad of Mises-Friedman-Hayek has led to market chaos that is not theoretical but Really Real.

 

According to Dan Mitchell's article Trading on Testosterone" in the New York Times, "Movements in financial markets are correlated to the levels of hormones in the bodies of male traders, according to a study by two researchers from the University of Cambridge."

 

The Adobe Photoshop image was created by adding the Suit to the bull and layering my own mortgage meltdown digitage with the article's illustration by Alex Eben Meyer in the New York Times. I saved this as a transparent .png file. (I am unsure of the licensing for the NYT image.) [1]

 

This is twisted curve in the winding road of ancient arguments that prohibited participation of hormone-driven women (emotional versus logical, intuitive versus deductive, feelings versus reason) in pivotal positions of decision-making.

 

read more | digg story

 

Does this mean the invisible hand of the market should be wearing a glove? Should the use of Viagra be monitored on the trading floor?

 

Notes

 

1. In response to the interesting question from Ray Randall re: Creative Commons Licensing of this images which he used here :

www.ethosadvisory.com/articles/index.php?id=418 and herehttp://www.ethosadvisory.com/blog. Ray is using CC for the first time and was confused and concerned about following Web 2.0 etiquette. It can be confusing.

 

This image is my digital collage or mashup as described above which is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 2.5 Canada License. Most of my Flickr images are under the Creative Commons License lets authors, scientists, artists, and educators easily mark their creative work with the freedoms they want it to carry while legally remixing and reusing fragments of the work of others.

 

When you add a Flickr image to your blog through Flickr's menu options, it automatically generates this code (I've replaced with [ and ])

[div style="float:right;margin-left:10px;margin-bottom:10px;"][a title="photo sharing" href="http://www.flickr.com/photos/oceanflynn/2426434212/"><img style="border:solid 2px #000000;" src="http://farm3.static.flickr.com/2231/2426434212_83d95ed5f5_m.jpg" alt="" /][/a]

 

[span style="font-size:.9em;margin-top:0;"]

[a href="http://www.flickr.com/photos/oceanflynn/2426434212/"]Bull Wrestling Bear Markets: Testosterone-driven[/a]

 

Originally uploaded by [a href="http://www.flickr.com/people/oceanflynn/"]ocean.flynn[/a]

[/span][/div]

 

By using Flickr's code the image is linked to image, artist and textual info.

 

I notice a lot of people bypass this and simply thank oceanflynn or Maureen Flynn-Burhoe which is fine for me because Google makes the link. It wouldn't if your name was not as easily identified by Google. And this method is not really Flickr-friendly.

  

However, Flickr has its own set of rules which requires that the live link to the Flickr-hosted image. This also accesses the accompanying explanatory text which describes how I added my own original mashups as well as remixing and reusing some of the work of other artists.

If you follow my links to the NYT's article you can see where the bull and bear originate. I put the bull in a Wall Street suit and tie and added my own original Adobe Photoshop image which was quite timely and involved. When you crop to include only the bear and bull, it is possible that it borrows too heavily from the original NYT's article illustration.

   

Webliography and Bibliography

Coates, J. M. and J. Herbert. 2008. "Endogenous steroids and financial risk taking on a London trading floor." Proceedings of the National Academy of Sciences. snurl.com/250a7

 

Emarketer. 2008-03-18. "Online Advertisers To Spend Through Turbulence." snurl.com/250e6

 

Flynn-Burhoe, Maureen. 2008-04-19. "Complex Financial Instruments and Testosterone-Driven Trading: Algorithm of Market Chaos." snurl.com/250a6

 

Mitchell, Dan. 2008-04-19. "Trading on Testosterone." New York Times. 5tvolz permalink

 

Palmer, Jason. 2008-04-14. "Traders' raging hormones cause stock market swings." NewScientist.com. snurl.com/2508n

 

Rubel, Steve. 2008-04-17. "Study: A Billion Dollars in Internet Advertising is Wasted." Micro Persuasion. snurl.com/250au

 

Rubel, Steve. 2008-04-19. Twitter.

 

Notes:

 

1. Algorithm: a "problem-solving procedure: a logical step-by-step procedure for solving a mathematical problem in a finite number of steps, often involving repetition of the same basic operation" or a "problem-solving computer program: a logical sequence of steps for solving a problem, often written out as a flow chart, that can be translated into a computer program," a term used in the late 17th century. It is an alteration, "after Greek arithmos "number," of algorism, via Old French and medieval Latin based on the Arabic al-Ḵwārizmī , the name of the 9th century mathematician who introduced algorithms to the West." See MSC (1998-2005) Encarta.

 

From 2022 all motor vehicles manufactured must be more energy efficient under a new EU directive.

 

Here sails are attached to the rear of a vehicle in what is being termed "Wind Assist Technology". It is reported that this can result in an efficiency gain of as much as 20% thus cutting emissions.

 

"Auto Fold" sensors drop the sail whenever the vehicle approaches a low bridge, multi-storey car park or telegraph pole - or when the wind is in the wrong direction.

City Roots Farm Microgreen Grower Heather waters the microgreens on Wednesday morning, August 10, 2022, in Columbia, S.C. City Roots is a family-owned local organic vegetable farm that uses environmentally-friendly farming practices, including composting and offsetting its carbon footprint with three photovoltaic solar panel arrays. The U.S. Department of Agriculture USDA Rural Development RD helped them toward their energy goals with a Rural Energy for America Program REAP Renewable Energy and Energy Efficiency Loans and Grants Program grant of $20,000.00 toward a $99,060.00 31.2 kW solar array that produces 44,858 kWh (82%) per year and provides a $5,382 of savings per year. REAP loans, and grants assist farmers, ranchers, and rural small businesses in developing renewable energy systems and making energy-efficiency improvements to their operations. USDA Media by Lance Cheung.

 

For more information about the REAP program, please go to rd.usda.gov/programs-services/energy-programs/rural-energy-america-program-renewable-energy-systems-energy-efficiency-improvement-guaranteed-loans

This is my own squad of custom clones. I'm planning on making a bunch of MOC's involving them. Please feel free to tag yourself, and also I'm horrible at naming clones, so any suggestions as to what to name any of these clones would be greatly appreciated.

Un CPD equivale a 25000 casas de EEUU!!

Siemens Energy Efficiency truck - view inside

The experience of our team at work on trucks to always guarantee maximum efficiency Follow Iveco's adventure at the Dakar!

Mercedes E350 CDi Blue Efficiency Cabriolet (2010-on) Engine 2987cc V6 E 300 BlueTEC Diesel 228bhp

MERCEDES SET

www.flickr.com/photos/45676495@N05/sets/72157623671722255...

 

The W212 Saloon and C207 Coupe were launched in 2009 as the ninth generation of the Mercedes E Class.Followed by the S212 Estate later in 2009 and the A207 Cabriolet unveiled at the North American Motor Show in Detroit, January 2010.

This is powered by a 2987cc V6 Diesel engine of 231bhp with a seven speed Automatic gearbox with Tipfunction, Speedtronic cruise control and hold

Priced at £ 48,005 includes the following extras - Telephone pre-wiring (£ 290). Airscarf (£ 365), COMAND (£ 2,230), AMG 5 twin spoke 18inch wheels (£ 365) and Diamond White metallic paint (£ 1,125)

 

Shot 25.11.2011 at Mercedes World Brooklands - Ref 68-459

 

Visitors please click on the Flag Counter on my Profile page. Thank you

Beddington Zero Energy Development

Sam's homework tonight for his physics class at Central Academy was to build a truss bridge out of toothpicks. Each of the students' bridges were then tested to see how much weight it would support and then the efficiency of the design was calculated. I haven't heard how the test turned out, but it made for an obvious subject for my 365 project photo.

Spaceflight (or space flight) is ballistic flight into or through outer space. Spaceflight can occur with spacecraft with or without humans on board. Yuri Gagarin of the Soviet Union was the first human to conduct a spaceflight. Examples of human spaceflight include the U.S. Apollo Moon landing and Space Shuttle programs and the Russian Soyuz program, as well as the ongoing International Space Station. Examples of unmanned spaceflight include space probes that leave Earth orbit, as well as satellites in orbit around Earth, such as communications satellites. These operate either by telerobotic control or are fully autonomous.

 

Spaceflight is used in space exploration, and also in commercial activities like space tourism and satellite telecommunications. Additional non-commercial uses of spaceflight include space observatories, reconnaissance satellites and other Earth observation satellites.

 

A spaceflight typically begins with a rocket launch, which provides the initial thrust to overcome the force of gravity and propels the spacecraft from the surface of the Earth. Once in space, the motion of a spacecraft – both when unpropelled and when under propulsion – is covered by the area of study called astrodynamics. Some spacecraft remain in space indefinitely, some disintegrate during atmospheric reentry, and others reach a planetary or lunar surface for landing or impact.

  

History

Main articles: History of spaceflight and Timeline of spaceflight

Tsiolkovsky, early space theorist

 

The first theoretical proposal of space travel using rockets was published by Scottish astronomer and mathematician William Leitch, in an 1861 essay "A Journey Through Space".[1] More well-known (though not widely outside Russia) is Konstantin Tsiolkovsky's work, "Исследование мировых пространств реактивными приборами" (The Exploration of Cosmic Space by Means of Reaction Devices), published in 1903.

 

Spaceflight became an engineering possibility with the work of Robert H. Goddard's publication in 1919 of his paper A Method of Reaching Extreme Altitudes. His application of the de Laval nozzle to liquid fuel rockets improved efficiency enough for interplanetary travel to become possible. He also proved in the laboratory that rockets would work in the vacuum of space;[specify] nonetheless, his work was not taken seriously by the public. His attempt to secure an Army contract for a rocket-propelled weapon in the first World War was defeated by the November 11, 1918 armistice with Germany. Working with private financial support, he was the first to launch a liquid-fueled rocket in 1926. Goddard's paper was highly influential on Hermann Oberth, who in turn influenced Wernher von Braun. Von Braun became the first to produce modern rockets as guided weapons, employed by Adolf Hitler. Von Braun's V-2 was the first rocket to reach space, at an altitude of 189 kilometers (102 nautical miles) on a June 1944 test flight.[2]

 

Tsiolkovsky's rocketry work was not fully appreciated in his lifetime, but he influenced Sergey Korolev, who became the Soviet Union's chief rocket designer under Joseph Stalin, to develop intercontinental ballistic missiles to carry nuclear weapons as a counter measure to United States bomber planes. Derivatives of Korolev's R-7 Semyorka missiles were used to launch the world's first artificial Earth satellite, Sputnik 1, on October 4, 1957, and later the first human to orbit the Earth, Yuri Gagarin in Vostok 1, on April 12, 1961.[3]

 

At the end of World War II, von Braun and most of his rocket team surrendered to the United States, and were expatriated to work on American missiles at what became the Army Ballistic Missile Agency. This work on missiles such as Juno I and Atlas enabled launch of the first US satellite Explorer 1 on February 1, 1958, and the first American in orbit, John Glenn in Friendship 7 on February 20, 1962. As director of the Marshall Space Flight Center, Von Braun oversaw development of a larger class of rocket called Saturn, which allowed the US to send the first two humans, Neil Armstrong and Buzz Aldrin, to the Moon and back on Apollo 11 in July 1969. Over the same period, the Soviet Union secretly tried but failed to develop the N1 rocket to give them the capability to land one person on the Moon.

Phases

Launch

Main article: Rocket launch

See also: List of space launch system designs

 

Rockets are the only means currently capable of reaching orbit or beyond. Other non-rocket spacelaunch technologies have yet to be built, or remain short of orbital speeds. A rocket launch for a spaceflight usually starts from a spaceport (cosmodrome), which may be equipped with launch complexes and launch pads for vertical rocket launches, and runways for takeoff and landing of carrier airplanes and winged spacecraft. Spaceports are situated well away from human habitation for noise and safety reasons. ICBMs have various special launching facilities.

 

A launch is often restricted to certain launch windows. These windows depend upon the position of celestial bodies and orbits relative to the launch site. The biggest influence is often the rotation of the Earth itself. Once launched, orbits are normally located within relatively constant flat planes at a fixed angle to the axis of the Earth, and the Earth rotates within this orbit.

 

A launch pad is a fixed structure designed to dispatch airborne vehicles. It generally consists of a launch tower and flame trench. It is surrounded by equipment used to erect, fuel, and maintain launch vehicles. Before launch, the rocket can weigh many hundreds of tonnes. The Space Shuttle Columbia, on STS-1, weighed 2,030 tonnes (4,480,000 lb) at take off.

Reaching space

 

The most commonly used definition of outer space is everything beyond the Kármán line, which is 100 kilometers (62 mi) above the Earth's surface. The United States sometimes defines outer space as everything beyond 50 miles (80 km) in altitude.

 

Rockets are the only currently practical means of reaching space. Conventional airplane engines cannot reach space due to the lack of oxygen. Rocket engines expel propellant to provide forward thrust that generates enough delta-v (change in velocity) to reach orbit.

 

For manned launch systems launch escape systems are frequently fitted to allow astronauts to escape in the case of emergency.

Alternatives

Main article: Non-rocket spacelaunch

 

Many ways to reach space other than rockets have been proposed. Ideas such as the space elevator, and momentum exchange tethers like rotovators or skyhooks require new materials much stronger than any currently known. Electromagnetic launchers such as launch loops might be feasible with current technology. Other ideas include rocket assisted aircraft/spaceplanes such as Reaction Engines Skylon (currently in early stage development), scramjet powered spaceplanes, and RBCC powered spaceplanes. Gun launch has been proposed for cargo.

Leaving orbit

 

This section possibly contains original research. Relevant discussion may be found on Talk:Spaceflight. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research should be removed. (June 2018) (Learn how and when to remove this template message)

Main articles: Escape velocity and Parking orbit

Launched in 1959, Luna 1 was the first known man-made object to achieve escape velocity from the Earth.[4] (replica pictured)

 

Achieving a closed orbit is not essential to lunar and interplanetary voyages. Early Russian space vehicles successfully achieved very high altitudes without going into orbit. NASA considered launching Apollo missions directly into lunar trajectories but adopted the strategy of first entering a temporary parking orbit and then performing a separate burn several orbits later onto a lunar trajectory. This costs additional propellant because the parking orbit perigee must be high enough to prevent reentry while direct injection can have an arbitrarily low perigee because it will never be reached.

 

However, the parking orbit approach greatly simplified Apollo mission planning in several important ways. It substantially widened the allowable launch windows, increasing the chance of a successful launch despite minor technical problems during the countdown. The parking orbit was a stable "mission plateau" that gave the crew and controllers several hours to thoroughly check out the spacecraft after the stresses of launch before committing it to a long lunar flight; the crew could quickly return to Earth, if necessary, or an alternate Earth-orbital mission could be conducted. The parking orbit also enabled translunar trajectories that avoided the densest parts of the Van Allen radiation belts.

 

Apollo missions minimized the performance penalty of the parking orbit by keeping its altitude as low as possible. For example, Apollo 15 used an unusually low parking orbit (even for Apollo) of 92.5 nmi by 91.5 nmi (171 km by 169 km) where there was significant atmospheric drag. But it was partially overcome by continuous venting of hydrogen from the third stage of the Saturn V, and was in any event tolerable for the short stay.

 

Robotic missions do not require an abort capability or radiation minimization, and because modern launchers routinely meet "instantaneous" launch windows, space probes to the Moon and other planets generally use direct injection to maximize performance. Although some might coast briefly during the launch sequence, they do not complete one or more full parking orbits before the burn that injects them onto an Earth escape trajectory.

 

Note that the escape velocity from a celestial body decreases with altitude above that body. However, it is more fuel-efficient for a craft to burn its fuel as close to the ground as possible; see Oberth effect and reference.[5] This is another way to explain the performance penalty associated with establishing the safe perigee of a parking orbit.

 

Plans for future crewed interplanetary spaceflight missions often include final vehicle assembly in Earth orbit, such as NASA's Project Orion and Russia's Kliper/Parom tandem.

Astrodynamics

Main article: Orbital mechanics

 

Astrodynamics is the study of spacecraft trajectories, particularly as they relate to gravitational and propulsion effects. Astrodynamics allows for a spacecraft to arrive at its destination at the correct time without excessive propellant use. An orbital maneuvering system may be needed to maintain or change orbits.

 

Non-rocket orbital propulsion methods include solar sails, magnetic sails, plasma-bubble magnetic systems, and using gravitational slingshot effects.

Ionized gas trail from Shuttle reentry

Recovery of Discoverer 14 return capsule by a C-119 airplane

Transfer energy

 

The term "transfer energy" means the total amount of energy imparted by a rocket stage to its payload. This can be the energy imparted by a first stage of a launch vehicle to an upper stage plus payload, or by an upper stage or spacecraft kick motor to a spacecraft.[6][7]

Reentry

Main article: Atmospheric reentry

 

Vehicles in orbit have large amounts of kinetic energy. This energy must be discarded if the vehicle is to land safely without vaporizing in the atmosphere. Typically this process requires special methods to protect against aerodynamic heating. The theory behind reentry was developed by Harry Julian Allen. Based on this theory, reentry vehicles present blunt shapes to the atmosphere for reentry. Blunt shapes mean that less than 1% of the kinetic energy ends up as heat that reaches the vehicle, and the remainder heats up the atmosphere.

Landing

 

The Mercury, Gemini, and Apollo capsules all splashed down in the sea. These capsules were designed to land at relatively low speeds with the help of a parachute. Russian capsules for Soyuz make use of a big parachute and braking rockets to touch down on land. The Space Shuttle glided to a touchdown like a plane.

Recovery

 

After a successful landing the spacecraft, its occupants and cargo can be recovered. In some cases, recovery has occurred before landing: while a spacecraft is still descending on its parachute, it can be snagged by a specially designed aircraft. This mid-air retrieval technique was used to recover the film canisters from the Corona spy satellites.

Types

Uncrewed

See also: Uncrewed spacecraft and robotic spacecraft

Sojourner takes its Alpha particle X-ray spectrometer measurement of Yogi Rock on Mars

The MESSENGER spacecraft at Mercury (artist's interpretation)

 

Uncrewed spaceflight (or unmanned) is all spaceflight activity without a necessary human presence in space. This includes all space probes, satellites and robotic spacecraft and missions. Uncrewed spaceflight is the opposite of manned spaceflight, which is usually called human spaceflight. Subcategories of uncrewed spaceflight are "robotic spacecraft" (objects) and "robotic space missions" (activities). A robotic spacecraft is an uncrewed spacecraft with no humans on board, that is usually under telerobotic control. A robotic spacecraft designed to make scientific research measurements is often called a space probe.

 

Uncrewed space missions use remote-controlled spacecraft. The first uncrewed space mission was Sputnik I, launched October 4, 1957 to orbit the Earth. Space missions where other animals but no humans are on-board are considered uncrewed missions.

Benefits

 

Many space missions are more suited to telerobotic rather than crewed operation, due to lower cost and lower risk factors. In addition, some planetary destinations such as Venus or the vicinity of Jupiter are too hostile for human survival, given current technology. Outer planets such as Saturn, Uranus, and Neptune are too distant to reach with current crewed spaceflight technology, so telerobotic probes are the only way to explore them. Telerobotics also allows exploration of regions that are vulnerable to contamination by Earth micro-organisms since spacecraft can be sterilized. Humans can not be sterilized in the same way as a spaceship, as they coexist with numerous micro-organisms, and these micro-organisms are also hard to contain within a spaceship or spacesuit.

Telepresence

 

Telerobotics becomes telepresence when the time delay is short enough to permit control of the spacecraft in close to real time by humans. Even the two seconds light speed delay for the Moon is too far away for telepresence exploration from Earth. The L1 and L2 positions permit 400-millisecond round trip delays, which is just close enough for telepresence operation. Telepresence has also been suggested as a way to repair satellites in Earth orbit from Earth. The Exploration Telerobotics Symposium in 2012 explored this and other topics.[8]

Human

Main article: Human spaceflight

ISS crew member stores samples

 

The first human spaceflight was Vostok 1 on April 12, 1961, on which cosmonaut Yuri Gagarin of the USSR made one orbit around the Earth. In official Soviet documents, there is no mention of the fact that Gagarin parachuted the final seven miles.[9] Currently, the only spacecraft regularly used for human spaceflight are the Russian Soyuz spacecraft and the Chinese Shenzhou spacecraft. The U.S. Space Shuttle fleet operated from April 1981 until July 2011. SpaceShipOne has conducted two human suborbital spaceflights.

Sub-orbital

Main article: Sub-orbital spaceflight

The International Space Station in Earth orbit after a visit from the crew of STS-119

 

On a sub-orbital spaceflight the spacecraft reaches space and then returns to the atmosphere after following a (primarily) ballistic trajectory. This is usually because of insufficient specific orbital energy, in which case a suborbital flight will last only a few minutes, but it is also possible for an object with enough energy for an orbit to have a trajectory that intersects the Earth's atmosphere, sometimes after many hours. Pioneer 1 was NASA's first space probe intended to reach the Moon. A partial failure caused it to instead follow a suborbital trajectory to an altitude of 113,854 kilometers (70,746 mi) before reentering the Earth's atmosphere 43 hours after launch.

 

The most generally recognized boundary of space is the Kármán line 100 km above sea level. (NASA alternatively defines an astronaut as someone who has flown more than 50 miles (80 km) above sea level.) It is not generally recognized by the public that the increase in potential energy required to pass the Kármán line is only about 3% of the orbital energy (potential plus kinetic energy) required by the lowest possible Earth orbit (a circular orbit just above the Kármán line.) In other words, it is far easier to reach space than to stay there. On May 17, 2004, Civilian Space eXploration Team launched the GoFast Rocket on a suborbital flight, the first amateur spaceflight. On June 21, 2004, SpaceShipOne was used for the first privately funded human spaceflight.

Point-to-point

 

Point-to-point is a category of sub-orbital spaceflight in which a spacecraft provides rapid transport between two terrestrial locations. Consider a conventional airline route between London and Sydney, a flight that normally lasts over twenty hours. With point-to-point suborbital travel the same route could be traversed in less than one hour.[10] While no company offers this type of transportation today, SpaceX has revealed plans to do so as early as the 2020s using its BFR vehicle.[11] Suborbital spaceflight over an intercontinental distance requires a vehicle velocity that is only a little lower than the velocity required to reach low Earth orbit.[12] If rockets are used, the size of the rocket relative to the payload is similar to an Intercontinental Ballistic Missile (ICBM). Any intercontinental spaceflight has to surmount problems of heating during atmosphere re-entry that are nearly as large as those faced by orbital spaceflight.

Orbital

Main article: Orbital spaceflight

Apollo 6 heads into orbit

 

A minimal orbital spaceflight requires much higher velocities than a minimal sub-orbital flight, and so it is technologically much more challenging to achieve. To achieve orbital spaceflight, the tangential velocity around the Earth is as important as altitude. In order to perform a stable and lasting flight in space, the spacecraft must reach the minimal orbital speed required for a closed orbit.

Interplanetary

Main article: Interplanetary spaceflight

 

Interplanetary travel is travel between planets within a single planetary system. In practice, the use of the term is confined to travel between the planets of our Solar System.

Interstellar

Main article: Interstellar travel

 

Five spacecraft are currently leaving the Solar System on escape trajectories, Voyager 1, Voyager 2, Pioneer 10, Pioneer 11, and New Horizons. The one farthest from the Sun is Voyager 1, which is more than 100 AU distant and is moving at 3.6 AU per year.[13] In comparison, Proxima Centauri, the closest star other than the Sun, is 267,000 AU distant. It will take Voyager 1 over 74,000 years to reach this distance. Vehicle designs using other techniques, such as nuclear pulse propulsion are likely to be able to reach the nearest star significantly faster. Another possibility that could allow for human interstellar spaceflight is to make use of time dilation, as this would make it possible for passengers in a fast-moving vehicle to travel further into the future while aging very little, in that their great speed slows down the rate of passage of on-board time. However, attaining such high speeds would still require the use of some new, advanced method of propulsion.

Intergalactic

Main article: Intergalactic travel

 

Intergalactic travel involves spaceflight between galaxies, and is considered much more technologically demanding than even interstellar travel and, by current engineering terms, is considered science fiction.

Spacecraft

Main article: Spacecraft

An Apollo Lunar Module on the lunar surface

 

Spacecraft are vehicles capable of controlling their trajectory through space.

 

The first 'true spacecraft' is sometimes said to be Apollo Lunar Module,[14] since this was the only manned vehicle to have been designed for, and operated only in space; and is notable for its non aerodynamic shape.

Propulsion

Main article: Spacecraft propulsion

 

Spacecraft today predominantly use rockets for propulsion, but other propulsion techniques such as ion drives are becoming more common, particularly for unmanned vehicles, and this can significantly reduce the vehicle's mass and increase its delta-v.

Launch systems

Main article: Launch vehicle

 

Launch systems are used to carry a payload from Earth's surface into outer space.

Expendable

Main article: Expendable launch system

 

Most current spaceflight uses multi-stage expendable launch systems to reach space.

 

Reusable

Main article: Reusable launch system

Ambox current red.svg

 

This section needs to be updated. Please update this article to reflect recent events or newly available information. (August 2019)

 

The first reusable spacecraft, the X-15, was air-launched on a suborbital trajectory on July 19, 1963. The first partially reusable orbital spacecraft, the Space Shuttle, was launched by the USA on the 20th anniversary of Yuri Gagarin's flight, on April 12, 1981. During the Shuttle era, six orbiters were built, all of which have flown in the atmosphere and five of which have flown in space. The Enterprise was used only for approach and landing tests, launching from the back of a Boeing 747 and gliding to deadstick landings at Edwards AFB, California. The first Space Shuttle to fly into space was the Columbia, followed by the Challenger, Discovery, Atlantis, and Endeavour. The Endeavour was built to replace the Challenger, which was lost in January 1986. The Columbia broke up during reentry in February 2003.

 

The Space Shuttle Columbia seconds after engine ignition on mission STS-1

 

Columbia landing, concluding the STS-1 mission

 

Columbia launches again on STS-2

 

The first automatic partially reusable spacecraft was the Buran (Snowstorm), launched by the USSR on November 15, 1988, although it made only one flight. This spaceplane was designed for a crew and strongly resembled the US Space Shuttle, although its drop-off boosters used liquid propellants and its main engines were located at the base of what would be the external tank in the American Shuttle. Lack of funding, complicated by the dissolution of the USSR, prevented any further flights of Buran.

 

Per the Vision for Space Exploration, the Space Shuttle was retired in 2011 due mainly to its old age and high cost of the program reaching over a billion dollars per flight. The Shuttle's human transport role is to be replaced by the partially reusable Crew Exploration Vehicle (CEV) no later than 2021. The Shuttle's heavy cargo transport role is to be replaced by expendable rockets such as the Evolved Expendable Launch Vehicle (EELV) or a Shuttle Derived Launch Vehicle.

 

Scaled Composites SpaceShipOne was a reusable suborbital spaceplane that carried pilots Mike Melvill and Brian Binnie on consecutive flights in 2004 to win the Ansari X Prize. The Spaceship Company has built its successor SpaceShipTwo. A fleet of SpaceShipTwos operated by Virgin Galactic planned to begin reusable private spaceflight carrying paying passengers (space tourists) in 2008, but this was delayed due to an accident in the propulsion development.[15]

 

Challenges

Main article: Effect of spaceflight on the human body

Space disasters

Main article: Space accidents and incidents

 

All launch vehicles contain a huge amount of energy that is needed for some part of it to reach orbit. There is therefore some risk that this energy can be released prematurely and suddenly, with significant effects. When a Delta II rocket exploded 13 seconds after launch on January 17, 1997, there were reports of store windows 10 miles (16 km) away being broken by the blast.[16]

 

Space is a fairly predictable environment, but there are still risks of accidental depressurization and the potential failure of equipment, some of which may be very newly developed.

 

In 2004 the International Association for the Advancement of Space Safety was established in the Netherlands to further international cooperation and scientific advancement in space systems safety.[17]

Weightlessness

Main article: Weightlessness

Astronauts on the ISS in weightless conditions. Michael Foale can be seen exercising in the foreground.

 

In a microgravity environment such as that provided by a spacecraft in orbit around the Earth, humans experience a sense of "weightlessness." Short-term exposure to microgravity causes space adaptation syndrome, a self-limiting nausea caused by derangement of the vestibular system. Long-term exposure causes multiple health issues. The most significant is bone loss, some of which is permanent, but microgravity also leads to significant deconditioning of muscular and cardiovascular tissues.

Radiation

 

Once above the atmosphere, radiation due to the Van Allen belts, solar radiation and cosmic radiation issues occur and increase. Further away from the Earth, solar flares can give a fatal radiation dose in minutes, and the health threat from cosmic radiation significantly increases the chances of cancer over a decade exposure or more.[18]

Life support

Main article: Life support system

 

In human spaceflight, the life support system is a group of devices that allow a human being to survive in outer space. NASA often uses the phrase Environmental Control and Life Support System or the acronym ECLSS when describing these systems for its human spaceflight missions.[19] The life support system may supply: air, water and food. It must also maintain the correct body temperature, an acceptable pressure on the body and deal with the body's waste products. Shielding against harmful external influences such as radiation and micro-meteorites may also be necessary. Components of the life support system are life-critical, and are designed and constructed using safety engineering techniques.

Space weather

Main article: Space weather

Aurora australis and Discovery, May 1991.

 

Space weather is the concept of changing environmental conditions in outer space. It is distinct from the concept of weather within a planetary atmosphere, and deals with phenomena involving ambient plasma, magnetic fields, radiation and other matter in space (generally close to Earth but also in interplanetary, and occasionally interstellar medium). "Space weather describes the conditions in space that affect Earth and its technological systems. Our space weather is a consequence of the behavior of the Sun, the nature of Earth's magnetic field, and our location in the Solar System."[20]

 

Space weather exerts a profound influence in several areas related to space exploration and development. Changing geomagnetic conditions can induce changes in atmospheric density causing the rapid degradation of spacecraft altitude in Low Earth orbit. Geomagnetic storms due to increased solar activity can potentially blind sensors aboard spacecraft, or interfere with on-board electronics. An understanding of space environmental conditions is also important in designing shielding and life support systems for manned spacecraft.

Environmental considerations

 

Rockets as a class are not inherently grossly polluting. However, some rockets use toxic propellants, and most vehicles use propellants that are not carbon neutral. Many solid rockets have chlorine in the form of perchlorate or other chemicals, and this can cause temporary local holes in the ozone layer. Re-entering spacecraft generate nitrates which also can temporarily impact the ozone layer. Most rockets are made of metals that can have an environmental impact during their construction.

 

In addition to the atmospheric effects there are effects on the near-Earth space environment. There is the possibility that orbit could become inaccessible for generations due to exponentially increasing space debris caused by spalling of satellites and vehicles (Kessler syndrome). Many launched vehicles today are therefore designed to be re-entered after use.

Indicator: Energy Efficiency (expressed in terajoules per million GDP in constant 2000 international PPP)

I was invited to spend two days at Europe’s most comprehensive IoT Event. This leading forum focused on case studies that show today’s Industry and Enterprises leveraging IoT technologies to transform their business through creating value and efficiencies.

 

The Internet of things (stylised Internet of Things or IoT) is the internetworking of physical devices, vehicles (also referred to as "connected devices" and "smart devices"), buildings and other items—embedded with electronics, software, sensors, actuators, and network connectivity that enable these objects to collect and exchange data.

 

"Things," in the IoT sense, can refer to a wide variety of devices such as heart monitoring implants, biochip transponders on farm animals, electric clams in coastal waters,[16] automobiles with built-in sensors, DNA analysis devices for environmental/food/pathogen monitoring or field operation devices that assist firefighters in search and rescue operations.[18] Legal scholars suggest to look at "Things" as an "inextricable mixture of hardware, software, data and service". These devices collect useful data with the help of various existing technologies and then autonomously flow the data between other devices. Current market examples include home automation (also known as smart home devices) such as the control and automation of lighting, heating (like smart thermostat), ventilation, air conditioning (HVAC) systems, and appliances such as washer/dryers, robotic vacuums, air purifiers, ovens or refrigerators/freezers that use Wi-Fi for remote monitoring.

mural on Riverside by Matt Tumlison

World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5)

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The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021

*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety

*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)

——————————————————————————

(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021

  

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According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.

 

The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.

, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent

What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of ​​the cell. The ribosome is the place where protein biosynthesis occurs.

Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.

Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell

(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology

(2) New crown vaccine design, molecular biology and chemical structure, etc.

(3) The generality and particularity of the development of new coronavirus drugs

(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.

(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.

(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities

(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.

(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.

(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.

(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus

(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and

The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.

(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,

Hepatitis virus,

Marburg virus

Sars coronavirus, plague, anthracnose, cholera

and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.

However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.

     Delta mutant strain

According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.

At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.

 

(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.

 

(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.

And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.

, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.

  

Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2~8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.

Efficiency Tischmesse Basel

25.10.2017 St.Jakobshalle in Basel / Schweiz

Efficiency Tischmesse ist eine Präsentationsplattform und Kontaktbörse für die regionale Wirtschaft. Die Teilnehmer präsentieren ihr Angebot auf einheitlichen, vom Veranstalter zur Verfügung gestellten Tischen. Diese sind nach einem einheitlichen System beschriftet. (Galerie zum Harnisch Schweiz)

 

Basel,Schweiz,Ausstellung,Besucher, Efficiency Tischmesse,

Exif_JPEG_PICTURE

International architectural think tank, LAVA, go green at Customs House.

 

Summary:

Summary:

Chris Bosse, Tobias Wallisser and Alexander Rieck’s LAVA (Laboratory for Visionary Architecture) launched the ‘Green Void’, a spectacular sculptural installation suspended in the central atrium of Sydney Customs House.

 

LAVA designed the ‘Green Void’ installation specifically for the Customs House central atrium which spans through all five levels. Suspended from the top level Café Sydney restaurant, a vertical distance of almost 20m, the sculpture provides an intense visual contrast to the beautifully restored heritage interior of Customs House. GREEN VOID is a digital design, derived from nature, realized in lightweight fabric, using the latest digital fabrication and engineering techniques, to create more with less. Comprised of 3000 cubic meters of space is enclosed within a minimal surface area of 300 square meters and uses only 40 kg of lightweight material.

 

The Customs House ‘Media Wall’ displays content across 11 video screens detailing the process of design, engineering, fabrication and installation of the sculpture along with recent international design projects completed by the LAVA team.

 

3D works by multimedia artist Peter Murphy creating 3d immersive imagery can be viewed without shutter glasses displayed over the new 3D screen technology.

 

The entire installation is immersed in a soundscape by sound artist David Chesworth, who created a “digital rainforest”.

 

Graphic design by emerging graphic designers TOKO, featuring a 3dimensionally layered catalogue, a wireframed mediawall, and projections onto the building.

 

Tensile Membrane Company Mak Max, the engineers and fabricators of the sculpture have developed a unique workflow from digital design to Digital Fabrication of complex shapes.

 

The exhibition is part of the continuous multidisciplinary program developed by Jennifer Kwok, the Manager of Customs House, to activate the public space with a focus on featuring contemporary architecture, photography and multimedia exhibitions.

   

Background:

 

The installation is inspired by the relationship between man, nature and technology. SENSUAL, GREEN and DIGITAL, the installation captures some of the key visions of the design team, which has over the past 12 months established offices in Sydney, Abu Dhabi and Stuttgart.

 

The project caps off a spectacular year for the trio and follows LAVA’s successful launch of the Michael Schumacher World Champion Tower (MSWCT) an ultra-luxury residential tower in October in Abu Dhabi, and the November launch of the future hotel Showcase suite in Germany.

 

The team also managed to pick up Best International Interior and the Sustainability Grant at the 2008 Interior Design Awards.

 

Chris’s work on the Watercube Swimming Centre for Beijing 2008 received the prestigious Atmosphere Award at the 9th Annual Venice Biennale and Chris was recently recognized as an emerging architect on the world stage by the RIBA London.

 

Tobias was instrumental in the emergence of the recent Stuttgart Mercedes-Benz Museum between 2002 and 2007 which has attracted worldwide attention for its innovative spatial concept.

  

concept

  

The installation is a ‘Minimal Surface’ that consists of a tensioned Lycra material, digitally patterned and custom-tailored for the space. The Five “funnels” of the sculpture reach out to connect the various levels and carefully hover just off the main interior atrium of the Customs House above the model of the city.

 

LAVA Asia Pacific Director Chris Bosse explains:

 

“The shape of the installation is not explicitly designed; it is rather the result of the most efficient connection of different boundaries in three-dimensional space, which can be found in nature in things like plants and corals. We only determined the connection points within the space and the rest is a mathematical formula, a minimal surface.

the concept was achieved with a flexible material that follows the forces of gravity, tension and growth, similar to a spider web or a coral reef. We are interested in the geometries in nature that create both, efficiency and beauty”

 

The lightweight fabric design follows the natural lines, contours and surface-tension of the fabric.

 

While appearing solid, the structure is soft and flexible and creates highly unusual spaces within customs house, which come to life with projection and lighting.

 

Since the 1970’s, with Frei Otto’s soap-bubble experiments for the Munich Olympic Stadium, naturally evolving systems have been an intriguing area of design research; something that hasn’t been lost on the team and their fascination with new building typologies and naturally developed structures.

 

Lava sought for advise and inspiration from American artist Alexandra Kasuba, who since Woodstock 1972 has created imaginative membrane sculptures around the world, followed by international artists such as Amish Kapoor and Ernesto Neto.

  

“We wanted to see how far we could take the idea of creating more space with less material, filling 3000 cubic meters, the equivalent of 8 million cola cans, with a minimal surface of 300 square meters weighting only 40 kg.”, emphasises Tobias Wallisser Director of LAVA Europe and professor of Digital Design at the State Academy of Fine Arts Stuttgart.

 

Rising up to the top level restaurant, a vertical distance of almost 20m, the sculpture provides an intense visual contrast to the beautifully restored heritage interior of Customs House.

 

The Customs House ‘Media Wall’ is also activated with content detailing the process of design, engineering, fabrication and installation of the sculpture along with recent design projects completed by LAVA across 12 video screens.

 

The whole installation is immersed in a soundscape by sound artist David Chesworth, who created a “digital rainforest”.

 

Graphic design by emerging graphic designers TOKO, featuring a 3dimensionally layered catalogue, a wireframed mediawall, and projections onto the building.

 

3D works by visual artist Peter Murphy creating 3d immersive imagery that can be viewed without shutter glasses thanks to a new technology.

 

Catalogue Essay by Matteo Cainer , Architecture Critic, London.

 

Key data:

Building Materials: Specially treated high-tech Nylon and light

Dimensions: approx. 21x8x12m

Surface Area:300 m2

Volume/space: 3000 m3

Weight: 40 kg

Construction/manufacturing time: 5 weeks

  

Green Void Credits:

 

Chris Bosse, Tobias Wallisser, Alexander Rieck

 

Jarrod Lamshed, Esan Rahmani, Kim Ngoc Nguyen, Anh Dao Trinh, Erik Escalante Mendoza, Pascal Tures, Mi Jin Chun, Andrea Dorici.

Contact:

  

Chris Bosse

Architect | Director

LAVA

Laboratory for Visionary Architecture

 

72 Campbell Street

Surry Hills

Sydney NSW 2010

Australia

 

Phone: +61 2 92801475

Fax: +61 2 92818125

Mobile OZ: +61 (0)410773260

Mobile UAE: +971(0)501514386

Mail: bosse@l-a-v-a.net

 

Press inquiries for LAVA:

Jane Silversmith

jane_silversmith@mac.com

M + 61 [0] 408 029 118

LAVA

directors@L-a-v-a.net

  

Mak max:

Kobi Tollitt

KobiT@tmcshade.com

Daniel Cook

DanielC@tmcshade.com

 

Suite 420 185 Elizabeth Street

Sydney NSW 2000

Freecall: 1800 777 727

  

Customs house:

Jennifer Kwok

JKWOK@CITYOFSYDNEY.NSW.GOV.AU

JENNIFER KWOK | MANAGER CUSTOMS HOUSE

LEVEL 2 31 ALFRED STREET CIRCULAR QUAY NSW 2000

TELEPHONE 02 9242 8591 | MOBILE 0419 205 086

         

Green Void Features

 

Digital Workflow

 

The project renounces on the application of a structure in the traditional sense. Instead, the space is filled with a 3-dimensional lightweight-sculpture, solely based on minimal surface tension, freely stretching between wall and ceiling and floor.

 

The design and fabrication procedure uses state-of-the-art digital workflow; beginning with 3D computer modelling, that is engineered structurally before undergoing a process of computer controlled (CNC) material cutting and mechanical re-seaming.

 

The computer-model, based on the simulation of complexity in naturally evolving systems, feeds directly into a production-line of sail-making-software and digital manufacturing.

 

The product shows a new way of digital workflow, enabling the generation of space out of a lightweight material that requires minimal adjustments onsite to achieve a complete installation in an extremely short time.

 

Sustainability

 

LAVA’s process of optimized minimal surface design and CNC (computer numeric code) fabrication technology allows the sculpture to reveal a new dimension in sustainable design practice.

 

Fulfilling the sustainable agenda of the venue, the work succeeds in its quest for optimum efficiency in material usage, construction weight, fabrication and installation time, while at the same time achieving maximum visual impact in the large atrium space.

 

The pavilion is easily transportable to any place in the world; can be quickly installed, and is fully reusable.

 

Fabrication

 

The sculpture materials consist of a double stretch, 2 way woven fabric that is mechanically attached to specially designed aluminium track profiles. Each profile is suspended from above, and to the side, on 2mm stainless steel cabling.

   

LAVA BACKGROUND

  

At the vanguard of a nonconformist and inventive new generation in architecture,

LAVA bridges the gap between the dream and the real world.

 

LAVA operates as a unique think tank with branches placed strategically worldwide. It has been formed by some of the most experienced and forward thinking architects from around the globe.

 

LAVA was founded by Chris Bosse and Tobias Wallisser in 2007. During its first year, the office has completed a wide range of projects in Germany, Australia and the U.A.E.

 

Chris Bosse is the director of LAVA Asia Pacific, based in Sydney, Australia. Chris is Adjunct Professor and Innovation fellow at the University of Technology, Sydney and lectures worldwide.

 

Educated in Germany and Switzerland, Chris worked with several high-profile European Architects before moving to Sydney. For a number of years Chris was

Associate Architect at PTW Architects in Sydney, completing many projects in China, Vietnam, the Middle-East and Japan.

 

Chris’s work on the Watercube Swimming Centre in Beijing received the prestigious Atmosphere Award at the 9th Annual Venice Biennale and Chris was recently recognized as an emerging architect on the world stage by the RIBA London.

 

Tobias Wallisser and Alexander Rieck are the directors of LAVA Europe and are based in Stuttgart, Germany. Tobias is Professor of Innovative Construction and Spatial concepts at the State Academy of Fine Arts Stuttgart.

 

After studying architecture in Berlin, Stuttgart and New York, Tobias worked in the United States, Netherlands and Germany. For 10 years Tobias was Associate Architect at UNStudio in Amsterdam, completing a series of high Profile projects and master plans including the World Trade Centre project in New York and the Arnhem Interchange.

 

Tobias was instrumental in the emergence of the recent Stuttgart Mercedes-Benz Museum which has attracted worldwide attention for its innovative spatial

concept.

 

Alexander works as a senior researcher at the renowned Fraunhofer Institute in Stuttgart. He studied architecture in Stuttgart and Phoenix and worked for a number of high-profile architects in Germany before joining the field of research. He started his research career in the Virtual Reality environment.

 

Alexander has led many of the Office 21 research projects that produced groundbreaking work in the field of future office organisation. He is a expert

on innovations in the fields of office, hotel, living and future construction, and an author of many publications about working environments and building processes of the future.

    

Research and Design Focus

 

LAVA’s research and design focus allows the evolution of architectural and urban design outcomes inaccessible through traditional methodologies.

 

Our process continually evolves; responding to global and market forces to deliver high quality, technologically advanced and sustainable projects that inspire a new generation.

 

LAVA Sydney and Stuttgart already have become hotspots and breeding grounds for a new generation of architectural talent.

  

Network Practice

 

LAVA works as a network practice, providing Visionary Architectural and Urban design services worldwide.

 

The LAVA network provides clients with access to an extensive team of leading design consultants and offers a comprehensive list of Architectural Design, Urban Design, Development Feasibility, Marketing and Master planning services.

 

Our collaboration with the Fraunhofer Institute enhances our work; we can call on cutting-edge research in the field of virtual environments, revolutionary office configurations, new materials and future scenarios.

 

Our longstanding collaboration with the architectural office WENZEL+WENZEL allows us to provide continuous services and to execute and coordinate individual projects from the beginning to the end.

 

Collaborations:

 

ARUP Advanced Geometry Unit | London

Fraunhofer Institute of Industrial Engineering | Stuttgart

Fraunhofer Institute of Solar Energy Systems | Freiburg

PNYG: COMPANY | Dubai

Werner Sobek Ingenieure | Stuttgart

Teuffel Engineering Consultants | Stuttgart

Transsolar Energietechnik | Stuttgart

Wenzel+Wenzel Architects | Stuttgart - Abu Dhabi

  

Recent Projects

 

Within the last year, we have worked on the following projects:

 

Sports Resort | U.A.E.

Architonic Lounge | Cologne

Office Tower | Abu Dhabi

Guest House Al Otaiba | U.A.E.

LBBW Headquarters | Stuttgart

Boutique Hotel Study | U.A.E.

Branded Tower Concept

Branded Tower | Abu Dhabi

Education City Sports Facilities | Doha

Pol Oxygen Pavilion | Sydney

Mixed use Tower | Stuttgart

Master plan Fuxin | China

Future Hotel Showcase | Duisburg

Hotel Jaegerstrasse | Stuttgart

Armstrong Pavilion | Munich

Zero Energy Houses | Saudi Arabia

   

Efficiencies and motel rooms--Week--Month--Season--Mr. & Mrs. Irl Rain

1845 Garfield Street, Hollywood in Florida.

 

phone 3-6026

 

Radio in each room--Shuffleboard--Beautiful, Landscaped Lot--Brand New and Modern--Near shopping district.

Advancing health system quality and efficiency by improving access, quality, and efficiency of public health services in Romania. Photo: Jutta Benzenberg/World Bank

Participant during the Session: “Enhancing Energy Efficiency“ at the Annual Meeting 2019 of the World Economic Forum in Davos, January 25, 2018. Congress Centre – xChange.Copyright by World Economic Forum / Christian Clavadetscher

The Energy Efficiency Center building of Tianjin, China. Photo: Yang Aijun / World Bank

 

Photo ID: YA-CN039 World Bank

Sandia mechanical operations engineer Casiano Armenta checks out a heat exchanger that’s part of the labs' free-cooling system. Free cooling has helped Sandia cut energy usage by more than 250 billion BTUs the past six years and reduce greenhouse gas emissions.

 

Read more at share.sandia.gov/news/resources/news_releases/sustainabil...

 

Photo by Randy Montoya.

» Watch the Torley Talks!

 

DESTINED FOR AWESOMENESS AND DON'T KNOW IT YET? This is a series of talks where Torley shares about life, creativity, and being human. I'll awaken you to understanding topics like: being a great orator, improving efficiency, and finding connections in the seemingly unrelated. Not your typical motivational speech, Torley had to craft this description to sound compelling, in hopes you'd watch. Heck, just watch and let me know what you think/feel/act upon.

Siemens Energy Efficiency truck - view outside

Siemens Energy Efficiency truck - view inside

Health & Efficiency @ Supersonic 2010

World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5)

_-----------------------------------------

The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021

*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety

*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)

——————————————————————————

(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021

  

-------------------------------------------------- ---------------------

    

According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.

 

The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.

, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent

What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of ​​the cell. The ribosome is the place where protein biosynthesis occurs.

Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.

Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell

(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology

(2) New crown vaccine design, molecular biology and chemical structure, etc.

(3) The generality and particularity of the development of new coronavirus drugs

(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.

(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.

(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities

(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.

(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.

(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.

(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus

(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and

The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.

(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,

Hepatitis virus,

Marburg virus

Sars coronavirus, plague, anthracnose, cholera

and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.

However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.

     Delta mutant strain

According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.

At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.

 

(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.

 

(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.

And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.

, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.

  

Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2~8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.

(2) Live attenuated vaccine: It is a vaccine made by using artificial targeted mutation methods or by screening live microorganisms with highly weakened or basically non-toxic virulence from the natural world. After inoculation, the live attenuated vaccine has a certain ability to grow and reproduce in the body, which can cause the body to have a reaction similar to a recessive infection or a mild infection, and it is widely used.

(3) Subunit vaccine: Among the multiple specific antigenic determinants carried by macromolecular antigens, only a small number of antigenic sites play an important role in the protective immune response. Separate natural proteins through chemical decomposition or controlled proteolysis, and extract bacteria and virusesVaccines made from fragments with immunological activity are screened out of the special protein structure of, called subunit vaccines. Subunit vaccines have only a few major surface proteins, so they can eliminate antibodies induced by many unrelated antigens, thereby reducing the side effects of the vaccine and related diseases and other side effects caused by the vaccine. (4) Genetically engineered vaccine: It uses DNA recombination biotechnology to direct the natural or synthetic genetic material in the pathogen coat protein that can induce the body's immune response into bacteria, yeast or mammalian cells to make it fully expressed. A vaccine prepared after purification. The application of genetic engineering technology can produce subunit vaccines that do not contain infectious substances, stable attenuated vaccines with live viruses as carriers, and multivalent vaccines that can prevent multiple diseases. This is the second-generation vaccine following the first-generation traditional vaccine. It has the advantages of safety, effectiveness, long-term immune response, and easy realization of combined immunization. It has certain advantages and effects.

New coronavirus drug development, drug targets and chemical modification.

Ligand-based drug design (or indirect drug design planning) relies on the knowledge of other molecules that bind to the target biological target. These other molecules can be used to derive pharmacophore models and structural modalities, which define the minimum necessary structural features that the molecule must have in order to bind to the target. In other words, a model of a biological target can be established based on the knowledge of the binding target, and the model can be used to design new molecular entities and other parts that interact with the target. Among them, the quantitative structure-activity relationship (QSAR) is included, in which the correlation between the calculated properties of the molecule and its experimentally determined biological activity can be derived. These QSAR relationships can be used to predict the activity of new analogs. The structure-activity relationship is very complicated.

Based on structure

Structure-based drug design relies on knowledge of the three-dimensional structure of biological targets obtained by methods such as X-ray crystallography or NMR spectroscopy and quantum chemistry. If the experimental structure of the target is not available, it is possible to create a homology model of the target and other standard models that can be compared based on the experimental structure of the relevant protein. Using the structure of biological targets, interactive graphics and medical chemists’ intuitive design can be used to predict drug candidates with high affinity and selective binding to the target. Various automatic calculation programs can also be used to suggest new drug candidates.

The current structure-based drug design methods can be roughly divided into three categories. The 3D method is to search a large database of small molecule 3D structures to find new ligands for a given receptor, in order to use a rapid approximate docking procedure to find those suitable for the receptor binding pocket. This method is called virtual screening. The second category is the de novo design of new ligands. In this method, by gradually assembling small fragments, a ligand molecule is established within the constraints of the binding pocket. These fragments can be single atoms or molecular fragments. The main advantage of this method is that it can propose novel structures that are not found in any database. The third method is to optimize the known ligand acquisition by evaluating the proposed analogs in the binding cavity.

Bind site ID

Binding site recognition is a step in structure-based design. If the structure of the target or a sufficiently similar homologue is determined in the presence of the bound ligand, the ligand should be observable in that structure, in which case the location of the binding site is small. However, there may not be an allosteric binding site of interest. In addition, only apo protein structures may be available, and it is not easy to reliably identify unoccupied sites that have the potential to bind ligands with high affinity. In short, the recognition of binding sites usually depends on the recognition of pits. The protein on the protein surface can hold molecules the size of drugs, etc. These molecules also have appropriate "hot spots" that drive ligand binding, hydrophobic surfaces, hydrogen bonding sites, and so on.

Drug design is a creative process of finding new drugs based on the knowledge of biological targets. The most common type of drug is small organic molecules that activate or inhibit the function of biomolecules, thereby producing therapeutic benefits for patients. In the most important sense, drug design involves the design of molecules with complementary shapes and charges that bind to their interacting biomolecular targets, and therefore will bind to them. Drug design often but does not necessarily rely on computer modeling techniques. A more accurate term is ligand design. Although the design technology for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, etc., which must be optimized first before the ligand can become safe and effective. drug. These other features are usually difficult to predict and realize through reasonable design techniques. However, due to the high turnover rate, especially in the clinical stage of drug development, in the early stage of the drug design process, more attention is paid to the selection of drug candidates. The physical and chemical properties of these drug candidates are expected to be reduced during the development process. Complications are therefore more likely to lead to the approval of the marketed drug. In addition, in early drug discovery, in vitro experiments with computational methods are increasingly used to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological characteristics. A more accurate term is ligand design. Although the design technique for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, iatrogenic effects, etc., which must be optimized first, and then the ligand To become safe and effective.

For drug targets, two aspects should be considered when selecting drug targets:

1. The effectiveness of the target, that is, the target is indeed related to the disease, and the symptoms of the disease can be effectively improved by regulating the physiological activity of the target.

2. The side effects of the target. If the regulation of the physiological activity of the target inevitably produces serious side effects, it is inappropriate to select it as the target of drug action or lose its important biological activity. The reference frame of the target should be expanded in multiple dimensions to have a big choice.

3. Search for biomolecular clues related to diseases: use genomics, proteomics and biochip technology to obtain biomolecular information related to diseases, and perform bioinformatics analysis to obtain clue information.

4. Perform functional research on related biomolecules to determine the target of candidate drugs. Multiple targets or individual targets.

5. Candidate drug targets, design small molecule compounds, and conduct pharmacological research at the molecular, cellular and overall animal levels.

Covalent bonding type

The covalent bonding type is an irreversible form of bonding, similar to the organic synthesis reaction that occurs. Covalent bonding types mostly occur in the mechanism of action of chemotherapeutic drugs. For example, alkylating agent anti-tumor drugs produce covalent bonding bonds to guanine bases in DNA, resulting in cytotoxic activity.

. Verify the effectiveness of the target.

Based on the targets that interact with drugs, that is, receptors in a broad sense, such as enzymes, receptors, ion channels, membranes, antigens, viruses, nucleic acids, polysaccharides, proteins, enzymes, etc., find and design reasonable drug molecules. Targets of action and drug screening should focus on multiple points. Drug intermediates and chemical modification. Combining the development of new drugs with the chemical structure modification of traditional drugs makes it easier to find breakthroughs and develop new antiviral drugs. For example, careful selection, modification and modification of existing related drugs that can successfully treat and recover a large number of cases, elimination and screening of invalid drugs from severe death cases, etc., are targeted, rather than screening and capturing needles in a haystack, aimless, with half the effort. Vaccine design should also be multi-pronged and focused. The broad-spectrum, long-term, safety, efficiency and redundancy of the vaccine should all be considered. In this way, it will be more powerful to deal with the mutation and evolution of the virus. Of course, series of vaccines, series of drugs, second-generation vaccines, third-generation vaccines, second-generation drugs, third-generation drugs, etc. can also be developed. Vaccines focus on epidemic prevention, and medicines focus on medical treatment. The two are very different; however, the two complement each other and complement each other. Therefore, in response to large-scale epidemics of infectious diseases, vaccines and various drugs are the nemesis and killers of viral diseases. Of course, it also includes other methods and measures, so I won't repeat them here.

Mainly through the comprehensive and accurate understanding of the structure of the drug and the receptor at the molecular level and even the electronic level, structure-based drug design and the understanding of the structure, function, and drug action mode of the target and the mechanism of physiological activity Mechanism-based drug design.

Compared with the traditional extensive pharmacological screening and lead compound optimization, it has obvious advantages.

Viral RNA replicase, also known as RNA-dependent RNA polymerase (RdRp) is responsible for the replication and transcription of RNA virus genome, and plays a very important role in the process of virus self-replication in host cells, and It also has a major impact on the mutation of the virus, it will change and accelerate the replication and recombination. Because RdRp from different viruses has a highly conserved core structure, the virus replicase is an important antiviral drug target and there are other selection sites, rather than a single isolated target target such as the new coronavirus As with various mutant viruses, inhibitors developed for viral replicase are expected to become a broad-spectrum antiviral drug. The currently well-known anti-coronavirus drug remdesivir (remdesivir) is a drug for viral replicase.

New antiviral therapies are gradually emerging. In addition to traditional polymerase and protease inhibitors, nucleic acid drugs, cell entry inhibitors, nucleocapsid inhibitors, and drugs targeting host cells are also increasingly appearing in the research and development of major pharmaceutical companies. The treatment of mutated viruses is becoming increasingly urgent. The development of drugs for the new coronavirus pneumonia is very important. It is not only for the current global new coronavirus epidemic, but more importantly, it is of great significance to face the severe pneumonia-respiratory infectious disease that poses a huge threat to humans.

There are many vaccines and related drugs developed for the new coronavirus pneumonia, and countries are vying for a while, mainly including the following:

Identification test, appearance, difference in loading, moisture, pH value, osmolality, polysaccharide content, free polysaccharide content, potency test, sterility test, pyrogen test, bacterial endotoxin test, abnormal toxicity test.

Among them: such as sterility inspection, pyrogen inspection, bacterial endotoxin, and abnormal toxicity inspection are indicators closely related to safety.

Polysaccharide content, free polysaccharide content, and efficacy test are indicators closely related to vaccine effectiveness.

Usually, a vaccine will go through a long research and development process of at least 8 years or even more than 20 years from research and development to marketing. The outbreak of the new crown epidemic requires no delay, and the design and development of vaccines is speeding up. It is not surprising in this special period. Of course, it is understandable that vaccine design, development and testing can be accelerated, shortened the cycle, and reduced some procedures. However, science needs to be rigorous and rigorous to achieve great results. The safety and effectiveness of vaccines are of the utmost importance. There must not be a single error. Otherwise, it will be counterproductive and need to be continuously improved and perfected.

Pre-clinical research: The screening of strains and cells is the basic guarantee to ensure the safety, effectiveness, and continuous supply of vaccines. Taking virus vaccines as an example, the laboratory stage needs to carry out strain screening, necessary strain attenuation, strain adaptation to the cultured cell matrix and stability studies in the process of passaging, and explore the stability of process quality, establish animal models, etc. . Choose mice, guinea pigs, rabbits or monkeys for animal experiments according to each vaccine situation. Pre-clinical research generally takes 5-10 years or longer on the premise that the process is controllable, the quality is stable, and it is safe and effective. In order to be safe and effective, a certain redundant design is also needed, so that the safety and effectiveness of the vaccine can be importantly guaranteed.

These include the establishment of vaccine strain/cell seed bank, production process research, quality research, stability research, animal safety evaluation and effectiveness evaluation, and clinical trial programs, etc.

The ARS-CoV-2 genome contains at least 10 ORFs. ORF1ab is converted into a polyprotein and processed into 16 non-structural proteins (NSP). These NSPs have a variety of functional biological activities, physical and chemical reactions, such as genome replication, induction of host mRNA cleavage, membrane rearrangement, autophagosome production, NSP polyprotein cleavage, capping, tailing, methylation, RNA double-stranded Uncoiling, etc., and others, play an important role in the virus life cycle. In addition, SARS-CoV-2 contains 4 structural proteins, namely spike (S), nucleocapsid (N), envelope (E) and membrane (M), all of which are encoded by the 3'end of the viral genome. Among the four structural proteins, S protein is a large multifunctional transmembrane protein that plays an important role in the process of virus adsorption, fusion, and injection into host cells, and requires in-depth observation and research.

1S protein is composed of S1 and S2 subunits, and each subunit can be further divided into different functional domains. The S1 subunit has 2 domains: NTD and RBD, and RBD contains conservative RBM. The S2 subunit has 3 structural domains: FP, HR1 and HR2. The S1 subunit is arranged at the top of the S2 subunit to form an immunodominant S protein.

The virus uses the host transmembrane protease Serine 2 (TMPRSS2) and the endosomal cysteine ​​protease CatB/L to enter the cell. TMPRSS2 is responsible for the cleavage of the S protein to expose the FP region of the S2 subunit, which is responsible for initiating endosome-mediated host cell entry into it. It shows that TMPRSS2 is a host factor necessary for virus entry. Therefore, the use of drugs that inhibit this protease can achieve the purpose of treatment.

mRNA-1273

The mRNA encoding the full length of SARS-CoV-2, and the pre-spike protein fusion is encapsulated into lipid nanoparticles to form mRNA-1273 vaccine. It can induce a high level of S protein specific antiviral response. It can also consist of inactivated antigens or subunit antigens. The vaccine was quickly approved by the FDA and has entered phase II clinical trials. The company has announced the antibody data of 8 subjects who received different immunization doses. The 25ug dose group achieved an effect similar to the antibody level during the recovery period. The 100ug dose group exceeded the antibody level during the recovery period. In the 25ug and 100ug dose groups, the vaccine was basically safe and tolerable, while the 250ug dose group had 3 levels of systemic symptoms.

Viral vector vaccines can provide long-term high-level expression of antigen proteins, induce CTLs, and ultimately eliminate viral infections.

1, Ad5-nCov

A vaccine of SARS-CoV-2 recombinant spike protein expressed by recombinant, replication-deficient type 5 adenovirus (Ad5) vector. Load the optimized full-length S protein gene together with the plasminogen activation signal peptide gene into the E1 and E3 deleted Ad5 vectors. The vaccine is constructed by the Admax system derived from Microbix Biosystem. In phase I clinical trials, RBD (S1 subunit receptor binding domain) and S protein neutralizing antibody increased by 4 times 14 days after immunization, reaching a peak on 28 days. CD4+T and CD8+T cells reached a peak 14 days after immunization. The existing Ad5 immune resistance partially limits the response of antibodies and T cells. This study will be further conducted in the 18-60 age group, receiving 1/3 of the study dose, and follow-up for 3-6 months after immunization.

DNA vaccine

The introduction of antigen-encoding DNA and adjuvants as vaccines is the most innovative vaccine method. The transfected cells stably express the transgenic protein, similar to live viruses. The antigen will be endocytosed by immature DC, and finally provide antigen to CD4 + T, CD8 + T cells (by MHC differentiation) To induce humoral and cellular immunity. Some specificities of the virus and the new coronavirus mutant are different from general vaccines and other vaccines. Therefore, it is worth noting the gene expression of the vaccine. Otherwise, the effectiveness and efficiency of the vaccine will be questioned.

Live attenuated vaccine

DelNS1-SARS-CoV2-RBD

Basic influenza vaccine, delete NS1 gene. Express SARS-CoV-2 RBD domain. Cultured in CEF and MDCK (canine kidney cells) cells. It is more immunogenic than wild-type influenza virus and can be administered by nasal spray.

The viral genome is susceptible to mutation, antigen transfer and drift can occur, and spread among the population. Mutations can vary depending on the environmental conditions and population density of the geographic area. After screening and comparing 7,500 samples of infected patients, scientists found 198 mutations, indicating the evolutionary mutation of the virus in the human host. These mutations may form different virus subtypes, which means that even after vaccine immunization, viral infections may occur. A certain amount of increment and strengthening is needed here.

 

Inactivated vaccines, adenovirus vector vaccines, recombinant protein vaccines, nucleic acid vaccines, attenuated influenza virus vector vaccines, etc. According to relevant information, there are dozens of new coronavirus vaccines in the world, and more varieties are being developed and upgraded. Including the United States, Britain, China, Russia, India and other countries, there are more R&D and production units.

AZ vaccine

Modena vaccine

Lianya Vaccine

High-end vaccine

Pfizer vaccine

 

Pfizer-BioNTech

A large study found that the vaccine developed by Pfizer and German biotechnology company BioNTech is 95% effective in preventing COVID-19.

The vaccine is divided into two doses, which are injected every three weeks.

This vaccine uses a molecule called mRNA as its basis. mRNA is a molecular cousin of DNA, which contains instructions to build specific proteins; in this case, the mRNA in the vaccine encodes the coronavirus spike protein, which is attached to the surface of the virus and used to infect human cells. Once the vaccine enters the human body, it will instruct the body's cells to make this protein, and the immune system will learn to recognize and attack it.

Moderna

The vaccine developed by the American biotechnology company Moderna and the National Institute of Allergy and Infectious Diseases (NIAID) is also based on mRNA and is estimated to be 94.5% effective in preventing COVID-19.

Like Pfizer's vaccine, this vaccine is divided into two doses, but injected every four weeks instead of three weeks. Another difference is that the Moderna vaccine can be stored at minus 20 degrees Celsius instead of deep freezing like Pfizer vaccine. At present, the importance of one of the widely used vaccines is self-evident.

Oxford-AstraZeneca

The vaccine developed by the University of Oxford and the pharmaceutical company AstraZeneca is approximately 70% effective in preventing COVID-19-that is, in clinical trials, adjusting the dose seems to improve this effect.

In the population who received two high-dose vaccines (28 days apart), the effectiveness of the vaccine was about 62%; according to early analysis, the effectiveness of the vaccine in those patients who received the half-dose first and then the full-dose Is 90%. However, in clinical trials, participants taking half doses of the drug are wrong, and some scientists question whether these early results are representative.

Sinopharm Group (Beijing Institute of Biological Products, China)

China National Pharmaceutical Group Sinopharm and Beijing Institute of Biological Products have developed a vaccine from inactivated coronavirus (SARS-CoV-2). The inactivated coronavirus is an improved version that cannot be replicated.

 

Estimates of the effectiveness of vaccines against COVID-19 vary.

Gamaleya Institute

The Gamaleya Institute of the Russian Ministry of Health has developed a coronavirus vaccine candidate called Sputnik V. This vaccine contains two common cold viruses, adenoviruses, which have been modified so that they will not replicate in the human body; the modified virus also contains a gene encoding the coronavirus spike protein.

  

New crown drugs

 

There are many small molecule antiviral drug candidates in the clinical research stage around the world. Including traditional drugs in the past and various drugs yet to be developed, antiviral drugs, immune drugs, Gene drugs, compound drugs, etc.

(A) Molnupiravir

Molnupiravir is a prodrug of the nucleoside analog N4-hydroxycytidine (NHC), jointly developed by Merck and Ridgeback Biotherapeutics.

The positive rate of infectious virus isolation and culture in nasopharyngeal swabs was 0% (0/47), while that of patients in the placebo group was 24% (6/25). However, data from the Phase II/III study indicate that the drug has no benefit in preventing death or shortening the length of stay in hospitalized patients.

Therefore, Merck has decided to fully advance the research of 800mg molnupiravir in the treatment of patients with mild to moderate COVID-19.

(B) AT-527

AT-527 is a small molecule inhibitor of viral RNA polymerase, jointly developed by Roche and Atea. Not only can it be used as an oral therapy to treat hospitalized COVID-19 patients, but it also has the potential as a preventive treatment after exposure.

Including 70 high-risk COVID-19 hospitalized patients data, of which 62 patients' data can be used for virological analysis and evaluation. The results of interim virological analysis show that AT-527 can quickly reduce viral load. On day 2, compared with placebo, patients treated with AT-527 had a greater decline in viral load than the baseline level, and the continuous difference in viral load decline was maintained until day 8.

In addition, compared with the control group, the potent antiviral activity of AT-527 was also observed in patients with a baseline median viral load higher than 5.26 log10. When testing by RT-qPCR to assess whether the virus is cleared,

The safety aspect is consistent with previous studies. AT-527 showed good safety and tolerability, and no new safety problems or risks were found. Of course, there is still a considerable distance between experiment and clinical application, and a large amount of experimental data can prove it.

(C) Prokrutamide

Prokalamide is an AR (androgen receptor) antagonist. Activated androgen receptor AR can induce the expression of transmembrane serine protease (TMPRSS2). TMPRSS2 has a shearing effect on the new coronavirus S protein and ACE2, which can promote the binding of viral spike protein (S protein) to ACE, thereby promoting The virus enters the host cell. Therefore, inhibiting the androgen receptor may inhibit the viral infection process, and AR antagonists are expected to become anti-coronavirus drugs.

Positive results were obtained in a randomized, double-blind, placebo-controlled phase III clinical trial. The data shows that Prokalutamide reduces the risk of death in severely ill patients with new coronary disease by 92%, reduces the risk of new ventilator use by 92%, and shortens the length of hospital stay by 9 days. This shows that procrulamide has a certain therapeutic effect for patients with severe new coronary disease, which can significantly reduce the mortality of patients, and at the same time greatly reduce the new mechanical ventilation and shorten the patient's hospital stay.

With the continuous development of COVID-19 on a global scale, in addition to vaccines and prevention and control measures, we need a multi-pronged plan to control this disease. Oral antiviral therapy undoubtedly provides a convenient treatment option.

 

In addition, there are other drugs under development and experimentation. In dealing with the plague virus, in addition to the strict control of protective measures, it is very important that various efficient and safe vaccines and various drugs (including medical instruments, etc.) are the ultimate nemesis and killer of the virus.

 

(A) "Antiviral biological missiles" are mainly drugs for new coronaviruses and mutant viruses, which act on respiratory and lung diseases. The drugs use redundant designs to inhibit new coronaviruses and variant viruses.

(B) "New Coronavirus Epidemic Prevention Tablets" mainly use natural purified elements and chemical structure modifications.

(C) "Composite antiviral oral liquid" antiviral intermediate, natural antiviral plant, plus other preparations

(D) "New Coronavirus Long-acting Oral Tablets" Chemical modification of antiviral drugs, multiple targets, etc.

(E) "New Coronavirus Inhibitors" (injections) are mainly made of chemical drug structure modification and other preparations.

The development of these drugs mainly includes: drug target screening, structure-activity relationship, chemical modification, natural purification, etc., which require a lot of work and experimentation.

Humans need to vigorously develop drugs to deal with various viruses. These drugs are very important for the prevention and treatment of viruses and respiratory infectious diseases, influenza, pneumonia, etc.

The history of human development The history of human evolution, like all living species, will always be accompanied by the survival and development of microorganisms. It is not surprising that viruses and infectious diseases are frequent and prone to occur. The key is to prevent and control them before they happen.

 

This strain was first discovered in India in October 2020 and was initially called a "double mutant" virus by the media. According to the announcement by the Ministry of Health of India at the end of March this year, the "India New Coronavirus Genomics Alliance" composed of 10 laboratories found in samples collected in Maharashtra that this new mutant strain carries E484Q and L452R mutations. , May lead to immune escape and increased infectivity. This mutant strain was named B.1.617 by the WHO and was named with the Greek letter δ (delta) on May 31.

Shahid Jamil, the dean of the Trivedi School of Biological Sciences at Ashoka University in India and a virologist, said in an interview with the Shillong Times of India that this mutant strain called "double mutation" is not accurate enough. B. 1.617 contains a total of 15 mutations, of which 6 occur on the spike protein, of which 3 are more critical: L452R and E484Q mutations occur on the spike protein and the human cell "Angiotensin Converting Enzyme 2 (ACE2)" receptor In the bound region, L452R improves the ability of the virus to invade cells, and E484Q helps to enhance the immune escape of the virus; the third mutation P681R can also make the virus enter the cell more effectively. (Encyclopedia website)

  

There are currently dozens of antiviral COVID-19 therapies under development. The large drugmakers Merck and Pfizer are the closest to the end, as expected, a pair of oral antiviral COVID-19 therapies are undergoing advanced human clinical trials.

Merck's drug candidate is called monupiravir. It was originally developed as an influenza antiviral drug several years ago. However, preclinical studies have shown that it has a good effect on SARS and MERS coronavirus.

Monupiravir is currently undergoing in-depth large-scale Phase 3 human trials. So far, the data is so promising that the US government recently pre-ordered 1.7 million courses of drugs at a cost of $1.2 billion. If everything goes according to plan, the company hopes that the drug will be authorized by the FDA for emergency use and be on the market before the end of 2021.

Pfizer's large COVID-19 antiviral drug candidate is more unique. Currently known as PF-07321332, this drug is the first oral antiviral drug to enter human clinical trials, specifically targeting SARS-CoV-2.

Variant of Concern WHO Label First Detected in World First Detected in Washington State

B.1.1.7 Alpha United Kingdom, September 2020 January 2021

B.1.351 Beta South Africa, December 2020 February 2021

P.1 Gamma Brazil, April 2020 March 2021

B.1.617.2 Delta India, October 2020 April 2021

  

Although this particular molecule was developed in 2020 after the emergence of the new coronavirus, a somewhat related drug called PF-00835231 has been in operation for several years, targeting the original SARS virus. However, the new drug candidate PF-07321332 is designed as a simple pill that can be taken under non-hospital conditions in the initial stages of SARS-CoV-2 infection.

"The protease inhibitor binds to a viral enzyme and prevents the virus from replicating in the cell," Pfizer said when explaining the mechanism of its new antiviral drug. "Protease inhibitors have been effective in the treatment of other viral pathogens, such as HIV and hepatitis C virus, whether used alone or in combination with other antiviral drugs. Currently marketed therapeutic drugs for viral proteases are generally not toxic Therefore, such molecules may provide well-tolerated treatments against COVID-19."

Various studies on other types of antiviral drugs are also gaining momentum. For example, the new coronavirus pneumonia "antiviral biological missile", "new coronavirus prevention tablets", "composite antiviral oral liquid", "new coronavirus long-acting oral tablets", "new coronavirus inhibitors" (injections), etc., are worthy of attention. Like all kinds of vaccines, they will play a major role in preventing and fighting epidemics.

In addition, Japanese pharmaceutical company Shionoyoshi Pharmaceutical is currently conducting a phase 1 trial of a protease inhibitor similar to SARS-CoV-2. This is called S-217622, ​​which is another oral antiviral drug, and hopes to provide people with an easy-to-take pill in the early stages of COVID-19. At present, the research and development of vaccines and various new crown drugs is very active and urgent. Time does not wait. With the passage of time, various new crown drugs will appear on the stage one after another, bringing the gospel to the complete victory of mankind.

  

The COVID-19 pandemic is far from over. The Delta mutant strain has quickly become the most prominent SARS-CoV-2 strain in the world. Although our vaccine is still maintained, it is clear that we need more tools to combat this new type of coronavirus. Delta will certainly not be the last new SARS-CoV-2 variant we encountered. Therefore, it is necessary for all mankind to persevere and fight the epidemic together.

Overcome illness and meet new challenges. The new crown epidemic and various mutated viruses are very important global epidemic prevention and anti-epidemic top priorities, especially for the current period of time. Vaccine injections, research and development of new drugs, strict prevention and control, wear masks, reduce gatherings, strictly control large gatherings, prevent the spread of various viruses Masks, disinfection and sterilization, lockdown of the city, vaccinations, accounting and testing are very important, but this does not mean that humans can completely overcome the virus. In fact, many spreading and new latently transmitted infections are still unsuccessful. There are detections, such as invisible patients, asymptomatic patients, migratory latent patients, new-onset patients, etc. The struggle between humans and the virus is still very difficult and complicated, and long-term efforts and exploration are still needed, especially for medical research on the new coronavirus. The origin of the disease, the course of the disease, the virus invaded The deep-level path and the reasons for the evolution and mutation of the new coronavirus and the particularity of prevention and treatment, etc.). Therefore, human beings should be highly vigilant and must not be taken lightly. The fierce battle between humans and various viruses must not be slackened. Greater efforts are needed to successfully overcome this pandemic, fully restore the normal life of the whole society, restore the normal production and work order, restore the normal operation of society, economy and culture, and give up food due to choking. Or eager for success, will pay a high price.

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References References are made to web resources, and related images are from web resources and related websites.

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Compilation postscript

Once Fang Ruida's research literature on the new crown virus and mutant virus was published, it has been enthusiastically praised by readers and netizens in dozens of countries around the world, and has proposed some amendments and suggestions. Hope to publish a multilingual version of the book as an emergency To meet the needs of many readers around the world, in the face of the new crown epidemic and the prevention and treatment of various mutant viruses, including the general public, college and middle school students, medical workers, medical colleagues and so on. According to the English original manuscript, it will be re-compiled and published. Inconsistencies will be revised separately. Thank you very much.

 

Jacques Lucy, Geneva, Switzerland, August 2021

 

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Leader mondial, scientifique, scientifique médical, virologue, pharmacien et professeur Fangruida (F.D Smith) sur l'épidémie mondiale et l'ennemi juré et la prévention des nouveaux coronavirus et virus mutants (Jacques Lucy 2021v1.5)

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L'ennemi juré et le tueur du nouveau coronavirus et des virus mutés - Développement conjoint de vaccins et de médicaments (Fangruida) Juillet 2021

* La particularité des nouveaux coronavirus et des virus mutants * Le large spectre, la haute efficacité, la redondance et la sécurité de la conception et du développement du nouveau vaccin contre le coronavirus, Redondance et sécurité

* Nouvelle modification de la structure chimique des médicaments contre les coronavirus * Conception et dépistage des médicaments assistés par ordinateur. *"Missile biologique antiviral", "Nouveaux comprimés anti-épidémiques contre le coronavirus", "Liquide oral antiviral composite", "Nouveaux comprimés oraux à action prolongée contre le coronavirus", "Nouveaux inhibiteurs de coronavirus" (injection)

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(leader mondial, scientifique, scientifique médical, biologiste, virologue, pharmacien, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" est un important document de recherche scientifique. Il a maintenant été révisé et réédité par l'auteur original à plusieurs reprises. La compilation est publiée et publiée selon le manuscrit original pour répondre aux besoins des lecteurs et des internautes du monde entier. En même temps, elle est également très bénéfique pour le grand nombre de chercheurs en médicaments cliniques médicaux et de divers experts et universitaires. Nous espérons qu'il sera corrigé dans la réimpression.------Compilé par Jacques Lucy à Genève, août 2021

  

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Selon les statistiques en temps réel de Worldometer, vers 6h30 le 23 juillet, il y avait un total de 193 323 815 cas confirmés de nouvelle pneumonie coronarienne dans le monde, et un total de 4 150 213 décès. Il y a eu 570 902 nouveaux cas confirmés et 8 766 nouveaux décès dans le monde en une seule journée. Les données montrent que les États-Unis, le Brésil, le Royaume-Uni, l'Inde et l'Indonésie sont les cinq pays avec le plus grand nombre de nouveaux cas confirmés, et l'Indonésie, le Brésil, la Russie, l'Afrique du Sud et l'Inde sont les cinq pays avec le plus grand nombre de nouveaux décès.

 

Les nouvelles souches de coronavirus et de mutants delta ont été particulièrement graves ces derniers temps. De nombreux pays et lieux ont repris vie et le nombre de cas n'a pas diminué, mais a augmenté.

, Il est digne de vigilance. Bien que de nombreux pays aient renforcé la prévention et le contrôle des vaccins et d'autres mesures de prévention et de contrôle, il existe encore de nombreuses lacunes et carences dans la suppression et la prévention du virus. Le nouveau coronavirus et diverses souches mutantes présentent un certain degré d'antagonisme par rapport aux médicaments traditionnels et à la plupart des vaccins. Bien que la plupart des vaccins aient de grandes propriétés anti-épidémiques et aient des effets et une protection importants et irremplaçables pour la prévention et le traitement, il est impossible d'empêcher complètement la propagation et l'infection des virus. La propagation de la nouvelle pneumonie à virus couronne a été retardée de près de deux ans. Il y a des centaines de millions de personnes infectées dans le monde, des millions de décès, et le temps est long, la propagation est généralisée et des milliards de personnes dans le monde sont parmi Les dommages causés par le virus sont assez terribles, c'est bien connu. Plus urgent

Ce qui est plus grave, c'est que le virus et les souches mutantes n'ont pas complètement reculé, surtout que de nombreuses personnes sont encore infectées et infectées après avoir été injectées avec divers vaccins.L'efficacité du vaccin et la résistance du virus mutant sont dignes des scientifiques médicaux, virologues , les pharmacologues Les zoologistes et autres réfléchissent et analysent sérieusement. La situation épidémique actuelle dans les pays européens et américains, la Chine, le Brésil, l'Inde, les États-Unis, la Russie et d'autres pays s'est considérablement améliorée par rapport à l'année dernière.Cependant, les chiffres pertinents montrent que la situation épidémique mondiale ne s'est pas complètement améliorée, et certains pays et régions sont encore très graves. En particulier, après une utilisation intensive de divers vaccins, des cas surviennent encore, et dans certains endroits ils sont encore très graves, ce qui mérite une grande vigilance. Les mesures de prévention et de contrôle sont très importantes.De plus, les vaccins et divers médicaments antiépidémiques sont les premiers choix nécessaires, et les autres méthodes sont irremplaçables. Il est particulièrement important de développer et de développer des médicaments complets, des médicaments antiviraux, des médicaments immunitaires et des médicaments génétiques. Les expériences de recherche sur les nouveaux coronavirus et virus mutants nécessitent une analyse plus rigoureuse et approfondie des données, des tissus pathogènes pathologiques, des gènes cellulaires, de la chimie moléculaire, de la chimie quantique, etc., ainsi que de la chimie moléculaire des vaccins, de la physique quantique, de la biologie quantique, de l'histologie cytologique, la chimie médicinale et les médicaments Et les symptômes, l'efficacité, la sécurité, l'efficacité à long terme, etc. du vaccin, bien sûr, y compris des dizaines de milliers de cas cliniques et de décès et d'autres informations et preuves de première main. La tâche de l'ARN (acide ribonucléique) dans le corps humain est d'utiliser les informations de notre matériel génétique ADN pour produire des protéines. Il accomplit cette tâche dans le ribosome, la zone productrice de protéines de la cellule. Le ribosome est le lieu où se produit la biosynthèse des protéines.

La médecine en profite : dans la vaccination, l'ARNm produit artificiellement fournit aux ribosomes des instructions pour construire des antigènes pathogènes contre lesquels lutter, par exemple, la protéine de pointe du coronavirus.

Les vaccins vivants traditionnels ou les vaccins inactivés contiennent des antigènes qui provoquent la réaction du système immunitaire. Le vaccin à ARNm est produit dans la cellule

(1) La spécificité des nouveaux coronavirus et virus mutants, etc., virologie et chimie quantique des virus mutants, physique quantique, microbiologie quantique

(2) Nouvelle conception de vaccin couronne, biologie moléculaire et structure chimique, etc.

(3) La généralité et la particularité du développement de nouveaux médicaments contre le coronavirus

(4) Diverses conceptions de médicaments pour la pneumonie à nouveau coronavirus, la chimie médicinale, la pharmacologie, etc., les cellules, les protéines, l'ADN, la chimie des enzymes, la chimie quantique pharmaceutique, la physique quantique pharmaceutique, la biochimie humaine, la biophysique humaine, etc.

(5) Les caractéristiques d'évolution et de mutation du nouveau coronavirus et de divers virus mutants, la nature à long terme, la répétabilité, la résistance aux médicaments et la résistance épidémique du virus, etc.

(6) Pneumonie à nouveau coronavirus et transmission infectieuse de divers nouveaux coronavirus et leurs particularités

(7) La transmission invisible de la pneumonie à nouveau coronavirus et de divers virus mutants chez l'homme ou l'animal, et la symbiose mutuelle de l'infection croisée de diverses bactéries et virus sont également l'une des causes très graves de dommages graves aux nouveaux coronavirus et virus mutants. La virologie, la pathologie, l'étiologie, le séquençage des gènes, la cartographie des gènes et un grand nombre d'études analytiques ont montré qu'il existe de nombreux cas en Chine, aux États-Unis, en Inde, en Russie, au Brésil et dans d'autres pays.

(8) Pour la prévention et le traitement symptomatiques du nouveau coronavirus, la combinaison de divers vaccins et de di

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