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Tumor angiogenesis (the exploitation of healthy cells to form new blood vessels) is a vital area of cancer research.
The two-panel image above shows one such promising lead from recent lab studies with endothelial cells, specialized cells that line the inside of all blood vessels. In tumors, endothelial cells are induced to issue non-stop SOS signals that falsely alert the body to dispatch needed materials to rescue these cells. The endothelial cells then use the help to replicate and sprout new blood vessels.
The left panel demonstrates the basics of this growth process under normal conditions. Endothelial cells (red and blue) were cultured under special conditions that help them grow in the lab. When given the right cues, those cells sprout spiky extensions to form new vessels.
But in the right panel, the cells can’t sprout. The reason is because the cells are bathed in a molecule called miR-30c, which isn’t visible in the photo. These specialized microRNA molecules—and humans make a few thousand different versions of them—control protein production by binding to and disabling longer RNA templates, called messenger RNA.
Read more: directorsblog.nih.gov/2019/09/05/using-microrna-to-starve...
Credit: Dudley Lab, University of Virginia School of Medicine, Charlottesville
NIH support from: National Cancer Institute; National Heart, Lung, and Blood Institute
Most tumors are made up of many different types of cancer cells (tumor heterogeneity), which often harbor unique genetic mutations. Researchers want to identify how different subgroups of cancer cells within a tumor affect the ability of cancer cells to metastasize or develop resistance to therapeutic agents. This image of a mouse model of pancreatic cancer shows multi-color lineage tracing ("confetti") and demonstrates that a sizeable number of metastases arise from heterogeneous cell clusters rather than the outgrowth of single cells.
This image was originally submitted as part of the 2016 NCI Cancer Close Up project and selected for exhibit.
See also
visualsonline.cancer.gov/closeup2016.
Credit: Ravikanth Maddipati, Abramson Cancer Center at the Univ. of Pennsylvania, National Cancer Institute, National Institutes of Health
The image shows a hematoxylin and Eosin (H&E) stain of a liver section belonging to an NSG mouse with metastatic infiltrate. Hepatocytes on lower left of image, with a mass of endothelial cells extravasating into the liver tissue from the upper right. Examining the response of the EC-infiltrated tissue and the overall health of the animal allows us to better understand the clinical implications of KS metastasis and target potential treatments. 200X magnification.
This image was chosen as a winner of the 2016 NIH funded research image call.
Credit: Imaging/tissue extraction by Anthony B. Eason; lab of Dirk Dittmer, University of North Carolina Lineberger Comprehensive Cancer Center. Mice maintained by UNC Animal Studies Core; staining by UNC Animal Histopathology Core.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
NIH funding from: National Cancer Institute (NCI)
From left to right: Andrea Goldstein, Caitlin McCarthy, and Cheryl Roth.
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
www.ginoandsharonphotography.co.uk/RACE-FOR-LIFE/
Today our aim was to capture the emotions at this beautiful event. Our thanks to everyone who took part. All our photos sold from this set we will donate all our profits to Cancer Research. Please help us support make a difference so if you see your friends in this album please send them the link. We were at 4 locations and we tried to get everyone who took part so please please please buy a print or download a photo ... Thank you so much... Gino and Sharon
Andrea Goldstein DES Daughter Activist Historian DES Issue
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
The support group Réseau DES France was established in 1994. Their first DES public education campaign was launched in 1997 with the brochure “DES Distilbène® Exposure, the questions you ask yourself” aimed at raising DES awareness amongst the general public. Since 1994 Réseau DES France has engaged in many areas (information, cooperation, advocacy and lobbying, and DES lawsuits to name just a few). They’ve achieved many results and successes such a the right to longer maternity leave for DES pregnancies.
Recently my nieces posted their 'no make-up selfies' online in aid of Cancer Research. Holding a tablespoon in one hand and trying to photograph with the XF 60mm macro lens attached to the X-Pro1 in the other wasn't easy. But, I managed it after a few attempts and here's the result. By the way that's me in the bowl of the spoon. Just a bit of creative fun :)
#nomakeupselfie has seen thousands go bare-faced online, and over one million raised for Cancer Research. Visit www.cruk.org to give your support.
5/27/09 - Dana Delany, Charles Gibson and Dr. William Nelson give an update on fundraising efforts marking the one year anniversary of "Stand Up To Cancer," on GOOD MORNING AMERICA. GM09 (ABC/ Ida Mae Astute).
(L to R) DIANE SAWYER, DANA DELANY, CHARLES GIBSON, DR. WILLIAM NELSON
Caitlin McCarthy, DES Daughter and screenwriter of WONDER DRUG (www.wonderdrugthemovie.com), an award-winning screenplay about the DES drug disaster.
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
Rhode Island Senator Jack Reed visits with a pediatric cancer patient in the Pediatric Oncology Branch at NIH on May 1, 2018. The 13 year old patient, Scarlett, is participating in a targeted immunotherapy clinical trial for children with relapsed or refractory leukemias and lymphomas.
Credit: National Institutes of Health
John Schorge DES Symposium Moderator MGH MD Chief Gynecology Oncology.
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
Issaac Schiff MD Chief MGH Vincent Department Obstetrics Gynecology
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
Cancer that has spread (metastasized) to the brain is normally untreatable because the protective blood-brain barrier blocks entry of most therapeutics. Nanoparticles capable of carrying drugs and "hitchhiking" across the barrier may allow the delivery of life-saving therapies to these tumors. This image shows blood vessels (red), cell nuclei (blue), and human metastatic breast cancer cells (green) in a mouse's brain, after intravenous administration of experimental nanoparticles that can cross the blood-brain barrier.
Credit: Emily Wyatt, Mark Davis, California Institute of Technology
NIH funding from: National Cancer Institute
DES Symposium Reception
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
In this image: Molecular view of DHHC palmitoyltransferases. Human DHHC20 (yellow) is embedded in the Golgi membrane (green), a compartment located inside cells. DHHC20 attaches a fatty acid chain (white) to a target protein (blue, foreground), which anchors the protein to the Golgi membrane.
NIH researchers have reported the first 3D structure of DHHC enzymes, which are involved in many cellular processes, including cancer. The finding promises to improve drug design for common forms of cancer.
More information: www.nih.gov/news-events/news-releases/nih-researchers-rep...
Credit: Jeremy Swan, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH
A recent study conducted by Marie-Odile Gobillard-Soyer, former director at the CNRS (French National Center for Scientific Research) and researcher in molecular biology, reveals a link between DES and mental illness issues. In January 2011, members of the association Hhorages, of which Marie-Odile is the President, were received by the AFFSSAPS (the equivalent of the Food and Drug Administration in the U.S.) to discuss her findings. Further to this meeting, a working group of experts from the AFFSSAPS and Hhorages has been established and will start cooperation in April.
British Freestyle Championship 2016 British Jetski Championship The Finals, Round 6 Lakeside Lake Doncaster South Yorkshire 04 September 2016 #JSRA #Finals www.networkimages.co.uk
DES Symposium Ether Dome
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
A recent study conducted by Marie-Odile Gobillard-Soyer, former director at the CNRS (French National Center for Scientific Research) and researcher in molecular biology, reveals a link between DES and mental illness issues. In January 2011, members of the association Hhorages, of which Marie-Odile is the President, were received by the AFFSSAPS (the equivalent of the Food and Drug Administration in the U.S.) to discuss her findings. Further to this meeting, a working group of experts from the AFFSSAPS and Hhorages has been established and will start cooperation in April.
Robert Young MD Department Pathology
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
Pictures taken during Clatterbridge Cancer Research's Firewalk. 16.10.10
Check out our site www.clatterbridge.org
Micheal Greene MGH MD Division Maternal Fetal Medicine
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
The boys (in order): Kyle Broflovski, Stanley "Stan" Marsh, Eric Theodore Cartman, Kenneth "Kenny" McCormick. and Gollum
Gollum quickly works out who is going to be his favourite fall guy hobbit - Kenny :D
Also Featuring Luci as Sugar luci.net-model.com
Photography by David Norrington Onion_Custard.net-model.com
As shown here, pancreatic cancer is associated with a vast desmoplastic reaction in which the connective tissue around the tumor thickens and scars. Tests similar to the one depicted here help distinguish between "good" and "bad" stromal reactions. Researchers hope this could allow the design of therapies that will reprogram tumor-stromal interaction. Cancerous cells are in red; nuclei are in blue; stroma/desmoplasia is in cyan; and stroma-specific markers are in yellow and green while marker overlays appear white.
This image was originally submitted as part of the 2016 NCI Cancer Close Up project and selected for exhibit.
See also visualsonline.cancer.gov/closeup2016.
Credit :Neelima Shah and Edna Cukierman, Fox Chase Cancer Center, National Cancer Institute, National Institutes of Health
Cancerous melanoma cells, shown with their cell bodies (green) and nuclei (blue),
are nestled in tiny hollow lumens (tubes) within the cryogel (red) structure.
This image was chosen as a winner of the 2016 NIH funded research image call.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Sidi A. Bencherif, Thomas Ferrante / Wyss Institute at Harvard University
NIH funding from: National Institute of Dental and Craniofacial Research (NIDCR)
The support group Réseau DES France was established in 1994. Their first DES public education campaign was launched in 1997 with the brochure “DES Distilbène® Exposure, the questions you ask yourself” aimed at raising DES awareness amongst the general public. Since 1994 Réseau DES France has engaged in many areas (information, cooperation, advocacy and lobbying, and DES lawsuits to name just a few). They’ve achieved many results and successes such a the right to longer maternity leave for DES pregnancies.
As an under-graduate student, Chanelle Case Borden studied the biomarkers of colorectal cancer at the NCI’s Center for
Cancer Research (CCR). After receiving her Ph.D., she returned to the CCR to work in the Experimental Immunology Branch investigating the function of bromodomain-containing protein 4 (BRD4), which plays a role in cancer and autoimmune diseases. She is currently a Fellow at the NCI’s Center for Cancer Training recruiting and mentoring scientists from diverse backgrounds.
Credit: David Sone
The "confetti mouse" is the name given to a strain of mice genetically engineered so that their cells glow in various combinations of red, blue, yellow, or green markers, depending on what particular proteins those cells are producing. This color coding, demonstrated here in mouse kidney cells, can be especially useful in cancer research, shedding light on subtle molecular differences among tumors and providing clues to what may be driving the spread, or metastasis, of cancer cells beyond the original tumor site.
This photo is a 2015 FASEB BioArt winner (www.faseb.org/bioart)
More info: directorsblog.nih.gov/2015/12/17/snapshots-of-life-bring-...
Credit: Heinz Baumann, Sean T. Glenn, Mary Kay Ellsworth, and Kenneth W. Gross, Roswell Park Cancer Institute, Buffalo, NY
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
NIH funding from: National Cancer Institute (NCI), and the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK)
In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients’ tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation. The researchers then showed that combining radiation therapy with cancer drugs designed to block DNA repair may be an effective treatment strategy. The study was funded by the National Institutes of Health.
Read more: www.nih.gov/news-events/news-releases/study-unveils-bluep...
Credit: Castro Lab, Michigan Medicine, Ann Arbor
NIH support from: National Institute of Neurological Disorders and Stroke
The WHOLE rehabilitation team is welcome here at ACRM
#ACRM2023
>>> World’s largest interdisciplinary rehabilitation research event <<<
ACRM 100th Annual Conference :: Progress in Rehabilitation Research — Translation to Clinical Practice
CORE CONFERENCE: 30 OCT – 2 NOV 2023
PRE-CON Instructional Courses: 28 – 30 OCT
ACRM holds the largest interdisciplinary rehabilitation research event every Fall: ACRM Annual Conference :: Progress in Rehabilitation Research :: Translation to Clinical Practice :: ACRMconference.org
For information on exhibiting, sponsoring, and advertising opportunities please contact sales@ACRM.org or phone +1.703.435.5335 or use this form ACRM.org/salesform.
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For the LOVE of #rehab #research BE HERE
At #ACRM, all members of the rehabilitation team are warmly welcomed in the spirit of helping to IMPROVE LIVES
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ACRM: American Congress of Rehabilitation Medicine: Improving lives through interdisciplinary rehabilitation research
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Caitlin McCarthy, DES Daughter and screenwriter of WONDER DRUG (www.wonderdrugthemovie.com), an award-winning screenplay about the DES drug disaster.
On May 19th 2011, the Massachusetts General Hospital (MGH) in Boston, Massachusetts, USA hosted a DES (Diethylstibestrol) symposium. DES daughters shared their experiences and discussed with DES specialists the lessons learned about embryogenesis, fertility, and carcinogenesis from in utero exposures. The DES symposium was free and open to the general public.
Altered lipid metabolism may be a key signature of cancer. Here, label-free stimulated Raman scattering imaging reveals the storage of cholesterol ester in lipid droplets (bright dots) in aggressive human prostate cancer. This finding may lead to new cancer drugs that work by blocking the activity of cholesterol esterification.
This image was originally submitted as part of the 2016 NCI Cancer Close Up project and selected for exhibit.
See also visualsonline.cancer.gov/closeup2016.
Credit: Ji-Xin Cheng, Purdue University Center for Cancer Research, National Cancer Institute, National Institutes of Health
Experiments by a team of NIH-funded scientists suggests a potential method for halting the expansion of certain brain tumors.
More information: www.nih.gov/news-events/news-releases/researchers-hit-bra...
Credit: Michelle Monje, M.D., Ph.D., Stanford University
NIH support from: National Institute of Neurological Disorders and Stroke and the National Center for Advancing Translational Sciences
Macrophage migration inhibitory factor (MIF) enhances disease aggressiveness and the metastatic potential of pancreatic cancer cells by inducing epithelial-to-mesenchymal transition (EMT). This image, obtained with confocal microscopy, shows enhanced vimentin expression (pink), a mesenchymal marker, in pancreatic cancer cells stably overexpressing MIF.
This image was originally submitted as part of the 2015 NCI Cancer Close Up project.
See also visualsonline.cancer.gov/closeup.
Credit: Naotake Funamizu, S. Perwez Hussain, NCI Center for Cancer Research, National Cancer Institute, National Institutes of Health