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20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
Shakhrisabz is, above all, associated with the Ak-Saray palace. Many amazing legends are linked with the history of the palace's construction. According to one of them, Timur began to think of building a magnificent edifice, summoned an architect and set out his objective. After listening to the ruler, the architect asked to be allowed into the state exchequer. When permission was granted, the craftsman started to make foundation blocks from clay mixed with gold in full view of Timur.
Seeing that the ruler remained impassive, he broke up the blocks and returned the gold to the exchequer. When Timur asked: "Why did you do that?" the architect replied: "So as to make sure of your determination to embark on constructing a building that requires vast expenditure." A second legend recounts that, after the main building work had been completed, Timur began to tell the craftsmen to hurry up and finish the decorative facing of the palace. But they were in no hurry to cover the building with majolica and mosaic. When the angry ruler ordered the chief architect to be brought before him, it emerged that had vanished after hanging a chain in the centre of the palace's main arch. Since no other craftsman of equal stature could be found, the building remained unfinished. Some time later, however, the architect suddenly appeared and, after making sure that the chain on the entrance arch was now considerably lower, embarked on decorating the building.
When Timur demanded an explanation of his strange flight and sudden reappearance, the architect replied: "I dared not disobey my sovereign's command, but I could not carry it out either. Stern punishment awaited me in either case, since such a majestic building had to settle and bed down firmly in the ground, otherwise all the decoration on it would be destroyed." The great ruler appreciated the craftsman's wisdom and resourcefulness.
The palace building in Shahrisabz took over a quarter of a century to construct. The Spanish ambassador, Ruy Gonzalez de Clavijo, who passed through Shahrisabz in 1404 on his way to the court of Timur in Samarkand, was astounded and charmed by the architectural miracle, and he left a detailed description of it, noting, however, that the splendid artistic decoration of the palace was still unfinished. The overall layout, scale and artistic appearance of Ak-Saray can be reconstituted from the descriptions of contemporaries and eyewitnesses, as well as from the results of archaeological excavation at the site. According to written accounts, the palace consisted of several stately, living or service quarters, grouped around separate courtyards.
The overall scale of the palace is impressive: the main courtyard alone, which has been reconstituted from the micro relief, was 120 - 125 m wide and 240 - 250 m long. The size of the other courtyards and of the outer perimeter of the palace has not been reconstructed owing to severe disturbance of the micro relief in the 15th - 16th centuries. Calculation of the proportions of the surviving elements of the site makes it fairly certain that the height of the main portal reached 70 m. It was topped by arched pinnacles (ko'ngra), while corner towers on a multifaceted pedestal were at least 80 m high. The main entrance portal was 50 m wide, and the arch had the largest span, 22.5 m, in Central Asia.
The architectural decor, featuring a wide variety of designs and colours, is particularly noteworthy in the artistic appearance of Ak-Saray. When using various techniques, however, the craftsmen bore in mind that the palace's main portal faced north, towards the capital, Samarkand. Given the poor light, the architects used only flat segmentation here and hence a continuous decorative treatment. The use of brick mosaic work, mainly dark and light blue in colour, forming large geometrical and epigraphic designs on a background of polished building brick, gives the portal a special softness of colour and an air of grand mystery.
The various mosaic and majolica work in the niche of the portal is particularly refined and highly coloured. The delicately executed ornamentation incorporates exquisite calligraphic inscriptions of mainly Koranic content, although secular ones are found too. In the midst of the decorative facing, an inscription has survived, giving the date of completion, 798 (1395 - 1396), and the name of the craftsman, Muhammad Yusuf Tebrizi (from the Azeri city of Tabriz). According to Clavijo, who visited Ak-Saray, "in this palace was a very long entrance and a very high portal, and by the entrance, to right and left, were brick arches covered with tiles painted with various designs. Beneath these arches was what looked like small rooms without doors, and the floor inside them was covered with tiles. This was done so that people could sit there when the king was present. Beyond this was another door and after that a large courtyard, paved with white slabs and surrounded by richly decorated galleries. In the middle of the courtyard was a large pool. The courtyard was some 300 paces wide, and it gave access to a large house, in which was a very high and wide door, decorated with gold, azure and tiles of very fine workmanship. In the middle, above the door, a lion was depicted, lying in the sun, and exactly the same picture was to be found at the edges. This was the device of the king of Samarkand. After this, the envoys were taken to look at the chamber that the king had appointed for sitting and feasting with his wives, very spacious and luxurious. Before it was a large garden with many shady and assorted fruit trees. Inside it were many pools and artfully sited meadows. By the entrance to this garden there was such a vast space that many people could have enjoyed themselves sitting there in the summertime beside the water and beneath the shade of the trees. The workmanship in the palace is so luxurious that, in order to describe everything well, one has to go and examine it a little at a time."
The Ak-Saray palace is a grandiose piece of civil architecture, and not just by Central Asian standards. Historical tradition ascribes the destruction of the majestic edifice to Abdullakhan, who, during one of the sieges of un-subdued Shahrisabz, is supposed to have ordered the splendid structures of Timur and his descendants to be demolished. Be that as it may, of the once luxurious royal palace only the pillars and part of the arch of the main portal remained by the second half of the 18th century.
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
"Evaluating Superpixels in Video: Metrics Beyond Figure-Ground Segmentation", by Peer Neubert and Peter Protzel
Day 3, Session 06. Wednesday 11th September
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
3D Printed Orthopedic Implants Market Global Trends, Market Share, Industry Size, Growth, Opportunities, and Market Forecast 2019 to 2026
Development of metal printing technologies, 510(k) clearance from the FDA (the US Food and Drug Administration), rise in orthopaedic disorders, development of 3D printed orthopaedic devices are factors promoting 3D printed orthopaedic implant market. The National Pharmaceutical Pricing Authority i.e. NPPAās recent view on margins of trade and cap prices is encouraging the 3D printed orthopaedic implants rigorous research and innovative findings activities. One of such promising results is that of dual mobility orthopaedic implants where patients with successful implants observed no or zero dislocation for at least 3 years post implants. Additionally, the approvals of robotic surgery systems for orthopaedic implants from the FDA is positively fortifying the investments by market players to provide advanced technological assistance during the implant procedures.
These factors serve as indicators that the global 3D printed orthopaedic implant market will strike a substantial CAGR during the forecast period from 2019-2026.
3D Printed Orthopedic Implant Market Restraints
Although the 3D printed orthopedic implants tend to be near perfect and precisely non-invasive due to use of artificial intelligence, they tend to be highly expensive. Reducing the prices for widely required implants like knee, shoulder and hip remains on the top health care agenda for the governments and medical associations across the world. The implant and surgical guides need to be used correctly to ensure complex 3d implants provide desired comfort and results. However very few market players provide assistance to the surgical teams post sales of personalised implant kit.
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Global 3D Printed Orthopedic Implant Market, by Implant Type
ā¢ Cranial/Facial Implant
ā¢ Spinal Implant
ā¢ Hip Implants
ā¢ Knee Implants
ā¢ Extremities Implants
Knee implants are a widespread practice due increase in the number of orthopaedic issues, rheumatic arthritis and ageing population. Hence knee implants are anticipated to grow at a healthy CAGR during the forecast period, followed by the hip implants.
Global 3D Printed Orthopedic Implant Market, by Material Type
ā¢ Metal
ā¢ Polymer
ā¢ Plastic
Implant material type segmentation is majorly dominated by metal segment, as titanium and calcium phosphate remain primary materials used in building regenerative implants for knees, spine hip and so on. The newer 3D printing technologies are facilitating innovative use of polymers along with bioactive materials that are anticipated to abode the global 3D printed orthopaedic implant surgeries at medical breakthrough horizons in coming years.
Global 3D Printed Orthopedic Implant Market, by End-User
ā¢ Hospital
ā¢ Outpatient Centres
ā¢ Ambulatory Surgical Centres
ā¢ Orthopedic Clinics
Global 3D Printed Orthopedic Implant Market, by Region:
ā¢ Europe
ā¢ North America
ā¢ APAC
ā¢ Latin America
ā¢ Rest of The World
Purchase a Copy & Ask For Discount: www.futurewiseresearch.com/request-sample.aspx?id=135&...
Competitive Landscape:
ā¢ Tier 1 players- established companies in the market with a major market share
ā¢ Tier 2 players
ā¢ Emerging players which are growing rapidly
ā¢ New Entrants
FutureWise Takeaways
ā¢ Growth prospects
ā¢ SWOT analysis
ā¢ Key trends
ā¢ Key data-points affecting market growth
Objectives of the Study:
ā¢ To provide with an exhaustive analysis on 3D printed orthopaedic implants market by implant type, material, end-user and region
ā¢ To cater comprehensive information on factors impacting market growth (drivers, restraints, opportunities, and industry-specific restraints)
ā¢ To evaluate and forecast micro-markets and the overall market
ā¢ To predict the market size, in key regions (along with countries)āNorth America, Europe, Asia Pacific, Latin America, and the Middle East
ā¢ To record evaluate and competitive landscape mapping- product launches, technological advancements, mergers and expansions
ā¢ Profiling of companies to evaluate their market shares, strategies, financials and core competencies
ā¢ To predict the market size, in key regions (along with countries)ā North America, Europe, Asia Pacific, Latin America and Middle East & Africa
ā¢ To record evaluate and competitive landscape mapping- product launches, technological advancements, mergers and expansions
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20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
Indiana is a U.S. state located in the midwestern and Great Lakes regions of North America. Indiana is the 38th largest by area and the 16th most populous of the 50 United States. Indiana is the least extensive state in the contiguous United States west of the Appalachian Mountains. Its capital and largest city is Indianapolis. Indiana was admitted to the United States as the 19th U.S. state on December 11, 1816.
Before it became a territory, varying cultures of indigenous peoples and historic Native Americans inhabited Indiana for thousands of years. Since its founding as a territory, settlement patterns in Indiana have reflected regional cultural segmentation present in the Eastern United States; the state's northernmost tier was settled primarily by people from New England and New York, Central Indiana by migrants from the Mid-Atlantic states and from adjacent Ohio, and Southern Indiana by settlers from the Southern states, particularly Kentucky and Tennessee.
Indiana has a diverse economy with a gross state product of $214 billion in 2005. Indiana has several metropolitan areas with populations greater than 100,000 and a number of smaller industrial cities and towns. Indiana is home to several major sports teams and athletic events including the NFL's Indianapolis Colts, the NBA's Indiana Pacers, the WNBAās Indiana Fever, and the Indianapolis 500 and Brickyard 400 motorsports races.
en.wikipedia.org/wiki/Wikipedia:Text_of_Creative_Commons_...
Shakhrisabz is, above all, associated with the Ak-Saray palace. Many amazing legends are linked with the history of the palace's construction. According to one of them, Timur began to think of building a magnificent edifice, summoned an architect and set out his objective. After listening to the ruler, the architect asked to be allowed into the state exchequer. When permission was granted, the craftsman started to make foundation blocks from clay mixed with gold in full view of Timur.
Seeing that the ruler remained impassive, he broke up the blocks and returned the gold to the exchequer. When Timur asked: "Why did you do that?" the architect replied: "So as to make sure of your determination to embark on constructing a building that requires vast expenditure." A second legend recounts that, after the main building work had been completed, Timur began to tell the craftsmen to hurry up and finish the decorative facing of the palace. But they were in no hurry to cover the building with majolica and mosaic. When the angry ruler ordered the chief architect to be brought before him, it emerged that had vanished after hanging a chain in the centre of the palace's main arch. Since no other craftsman of equal stature could be found, the building remained unfinished. Some time later, however, the architect suddenly appeared and, after making sure that the chain on the entrance arch was now considerably lower, embarked on decorating the building.
When Timur demanded an explanation of his strange flight and sudden reappearance, the architect replied: "I dared not disobey my sovereign's command, but I could not carry it out either. Stern punishment awaited me in either case, since such a majestic building had to settle and bed down firmly in the ground, otherwise all the decoration on it would be destroyed." The great ruler appreciated the craftsman's wisdom and resourcefulness.
The palace building in Shahrisabz took over a quarter of a century to construct. The Spanish ambassador, Ruy Gonzalez de Clavijo, who passed through Shahrisabz in 1404 on his way to the court of Timur in Samarkand, was astounded and charmed by the architectural miracle, and he left a detailed description of it, noting, however, that the splendid artistic decoration of the palace was still unfinished. The overall layout, scale and artistic appearance of Ak-Saray can be reconstituted from the descriptions of contemporaries and eyewitnesses, as well as from the results of archaeological excavation at the site. According to written accounts, the palace consisted of several stately, living or service quarters, grouped around separate courtyards.
The overall scale of the palace is impressive: the main courtyard alone, which has been reconstituted from the micro relief, was 120 - 125 m wide and 240 - 250 m long. The size of the other courtyards and of the outer perimeter of the palace has not been reconstructed owing to severe disturbance of the micro relief in the 15th - 16th centuries. Calculation of the proportions of the surviving elements of the site makes it fairly certain that the height of the main portal reached 70 m. It was topped by arched pinnacles (ko'ngra), while corner towers on a multifaceted pedestal were at least 80 m high. The main entrance portal was 50 m wide, and the arch had the largest span, 22.5 m, in Central Asia.
The architectural decor, featuring a wide variety of designs and colours, is particularly noteworthy in the artistic appearance of Ak-Saray. When using various techniques, however, the craftsmen bore in mind that the palace's main portal faced north, towards the capital, Samarkand. Given the poor light, the architects used only flat segmentation here and hence a continuous decorative treatment. The use of brick mosaic work, mainly dark and light blue in colour, forming large geometrical and epigraphic designs on a background of polished building brick, gives the portal a special softness of colour and an air of grand mystery.
The various mosaic and majolica work in the niche of the portal is particularly refined and highly coloured. The delicately executed ornamentation incorporates exquisite calligraphic inscriptions of mainly Koranic content, although secular ones are found too. In the midst of the decorative facing, an inscription has survived, giving the date of completion, 798 (1395 - 1396), and the name of the craftsman, Muhammad Yusuf Tebrizi (from the Azeri city of Tabriz). According to Clavijo, who visited Ak-Saray, "in this palace was a very long entrance and a very high portal, and by the entrance, to right and left, were brick arches covered with tiles painted with various designs. Beneath these arches was what looked like small rooms without doors, and the floor inside them was covered with tiles. This was done so that people could sit there when the king was present. Beyond this was another door and after that a large courtyard, paved with white slabs and surrounded by richly decorated galleries. In the middle of the courtyard was a large pool. The courtyard was some 300 paces wide, and it gave access to a large house, in which was a very high and wide door, decorated with gold, azure and tiles of very fine workmanship. In the middle, above the door, a lion was depicted, lying in the sun, and exactly the same picture was to be found at the edges. This was the device of the king of Samarkand. After this, the envoys were taken to look at the chamber that the king had appointed for sitting and feasting with his wives, very spacious and luxurious. Before it was a large garden with many shady and assorted fruit trees. Inside it were many pools and artfully sited meadows. By the entrance to this garden there was such a vast space that many people could have enjoyed themselves sitting there in the summertime beside the water and beneath the shade of the trees. The workmanship in the palace is so luxurious that, in order to describe everything well, one has to go and examine it a little at a time."
The Ak-Saray palace is a grandiose piece of civil architecture, and not just by Central Asian standards. Historical tradition ascribes the destruction of the majestic edifice to Abdullakhan, who, during one of the sieges of un-subdued Shahrisabz, is supposed to have ordered the splendid structures of Timur and his descendants to be demolished. Be that as it may, of the once luxurious royal palace only the pillars and part of the arch of the main portal remained by the second half of the 18th century.
(www.adgorithms.c(www.adgorithms.com) - om) - The major benefit of performance advertising is that your product can be seen the second it has gone online.
"Evaluating Superpixels in Video: Metrics Beyond Figure-Ground Segmentation", by Peer Neubert and Peter Protzel
Day 3, Session 06. Wednesday 11th September
This times the noted dissertation segments sequences. Get ready for the wise words and a nice cake! The event is open everyone. :)
(The reflection of the the photo capturer can be seen in this picture.)
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
The segmentation between the archway stones is not showing. I will either have to increase the space between them or increase the render quality.
This monument, like the court tomb in Laraghirril, which lies 1.5km to the W, stands in the relatively low-lying plain of good agricultural land stretching from Trawbreaga Bay on the W side of the Inishowen peninsula to Tremone Bay on its NE flank.
The monument, orientated approximately E-W, has been considerably damaged. It consists of the ruins of an unroofed segmented gallery, now almost 10m in overall length, set in a long mound. According to R.S. Young (1897), the gallery had been covered by a cairn of earth and rubble until it was exposed by the tenant when searching for stones. There are a considerable number of sizeable slabs and variously sized fragments of others lying at the site, particularly at the eastern end of the gallery. These are not shown on the plan. According to local information, dynamite was used to dislodge stones from the structure in the early part of the 20th century. Boreholes visible in three of the larger blocks of stone seem to confirm this.
The mound measures c. 30m E-W and narrows from c. 13m at the W to 10m close to its E end. It reaches a maximum height of c. 1m. Apart from spreads of stone near the gallery, it is largely grass grown. In 1982, when the plan published here was made, an extensive dump of material derived from field clearance obscured the western end of the mound. Since then similar material has been dumped in smaller amounts at other points adjacent to or on the perimeter of the mound.
The gallery appears to have consisted of at least three chambers. That at the E is largely destroyed, and all that survives are three orthostats of its northern side. The easternmost of these is 0.6m in exposed height. The second rises 0.4m above the top of the first. The third lies 0.6m W of and is 0.25m taller than the second. It partly overlaps the segmentation between the eastern and middle chambers. This segmentation is marked by a jamb placed longitudinally inside the line of the N side of the gallery, with an inclined sillstone set at right angles to its E end. The jamb is 0.8m high and rises 0.45m above the sill. There is sufficient space between the end of the sillstone and the S side of the gallery to accommodate a second jamb.
The middle chamber is c. 3.5m long and 1.7m wide. Three orthostats form each side. On the N side the easternmost orthostat and the stone next to it are the same height as the segmenting jamb already described, but both may originally have been taller, as they appear to be broken. The third orthostat on this side is a tall pillar-like stone that rises 0.6m above the other two. The heights of the orthostats on the S side of this chamber from E to W are 0.95m, 0.7m and 1.2m. A displaced slab (not on plan) lies to the S of this chamber.
The jambs dividing the middle chamber from the western chamber are set longitudinally inside the gallery walls. These are 0.8m apart but are only partly opposite each other. The southern one is 1.6m high. The northern one leans southward across the gallery and if upright would be the same height as the southern. The sole surviving sidestone of the western chamber adjoins the leaning jamb. It is 0.9m high. A large displaced slab, measuring at least 1.7m by 1.6m and 0.4m thick, lies across this ruined chamber. Its southern end rests on a stone protruding at an angle from the cairn material exposed here. Approximately 1.5m WSW of this is a firmly set stone 0.6m high. The status of these two stones is not clear. According to 'Maghtochair' (1867, 15), a large roofstone then covered one of the three chambers, but he did not specify which one. The large roofstone is also mentioned in an OS Name Book of 1848.
Whether there were more than the three chambers now apparent in the gallery cannot be established, nor is it known at which end the entrance lay.
The above description was published in the 'Survey of the Megalithic Tombs of Ireland. Volume VI, County Donegal.' Compiled by: Eamon Cody.
(www.adgorithms.com) - The information and the substance will not be restricted by your potential customersā place and/or time. In short, your performance advertising is online 24 hours a day, 7 days a week.
Photo by Vicki Rogers
Some sandstone in the Santa Cruz Mountains have variable levels of calcium carbonate segmentation resulting is certain parts being softer than others. The heavy rainfalls in our mountains contain carbon dioxide from the air which seeps into the sandstone and dissolves the softer areas of calcium carbonate holding the sand grains in place. During our dry season (we do have a short one,) the calcium carbonate is drawn to the rock's surface forming a deposit that resists erosion. This leaves the uncemented sand below to crumble away. The resulting caves and honeycomb formations are called tafoni.
There are three areas in the Santa Cruz Mountains, all off of Skyline Boulevard (Highway 35,) that are particularly known for their tafoni. The most well known is at Castle Rock State Park. The sandstone here is hard enough that climbing is allowed and on 80-foot high sandstone outcropping is particularly popular.
Across Skyline Boulevard from Castle Rock in Sanborn County Park their is Summit Rock. With an elevation of 3076 feet you can take in the tafoni along with a nice panorama view of the Silicon Valley. On the down side, there is some graffiti on Summit Rock probable. The county parks just aren't as well policed as state parks and the hike is short enough that slobs can find their way to deface this natural beauty.
The third area of noted tafoni is located in the El Corte de Madera Creek Open Space Preserve between Highway 92 and Woodside Road at Skegg's Point Caltrans Rest Stop. The rock is only 2.5 mile hike from Highway 35. However, the bad guys haven't discovered this area yet so please only tell your responsible friends. There are 33 miles of multi-use trains within this 2,821-acre preserve. The preserve was established to protect the headwaters of the San Gregorio Creek watershed that is critical habitat for steelhead trout and coho salmon. Therefore, certain trails have been closed to the public to enable restoration. Failure of visitors to respect these closures could easily result in the entire preserve being closed to the public. The sandstone at El Corte de Madera Creek is softer and more fragile than at places such as Castle Rock and climbing is not allowed here. The up side of the rock being more fragile is that the tafoni is more spectacular. So, we highly recommend this preserve to our responsible flickr photographer friends. The light at the sandstone is very filtered and I really needed to carry a sturdier tripod (I normally just have a Trekpod) and a strong external flash for flash fill. Next time I'm bringing these items along.
This orange dropped off the tree before fully ripe. When I finally cut it open tonight, I saw that it had a very odd composition.
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Trichocereus often times grow bad and weird in Arizona because of the extreme heat like this plant with mass segmentation. In California they grow BEAUTIFUL.
(www.adgorithms.com) - A new window comes out in front of the current window that the user is in. It will show either an advertisement or an entire webpage of the product.
Learn how Veriflow's continuous network verification uses processes similar to those used by NASA's Mars rovers to keep your networks up and running. Request a live demo: www.veriflow.net/demo/
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Veriflow: Continuous Network Verification
Spirit and Opportunity the two Mars rovers launched in 2003 by NASA. Both
were expected to work for 90 Martian days. Spirit lasted 25 times its life expectancy and today Opportunity is still exploring the Red Planet.
How does NASA design its technology so successfully? One answer is formal verification, mathematical analysis of where to predict problems before takeoff. At Veriflow, our mission is to eliminate outages and vulnerabilities within networks. We use our own patented continuous network verification similar to NASA's processes but developed specifically for networks.
Veriflow deeply analyzes every device in your network infrastructure to create a predictive model of all possible network-wide data flows. Better flow checks that your network meets your segmentation policies to ensure multiple layers of defense, pinpointing any vulnerabilities that could be exploited. Veriflow ensures your critical applications are always online. So, when you change a configuration or upgrade devices it will identify any unintended consequences.
Regulatory compliance? Veriflow has that covered too. Through continuous and automatic verification of the network. So, you always operate according to industry standards and regulations. Not only that, with a dynamic and detailed map of your network there's no need for tedious manual drawings.
Interactive visualization and search lets you rapidly isolate the root cause of any incident allowing response in minutes instead of hours or days. So, what does this all mean? Network engineers no longer need to rely on error-prone manual tests or take a risky wait-and-see approach by monitoring live flows.
Veriflow lets you predict your networks future by detecting vulnerabilities before they become outages or breaches and it gives you the confidence to make changes without worry. We call it continuous Network verification and it's exclusive to Veriflow.
Every business in every industry relies on its network connecting customers to your service is vital and we ensure that networks don't fail. Curiosity and Opportunity continue to send data back to earth. Their dependability is a testament to the power of verification.
At Veriflow we've developed the same mathematical principles to protect your business. Get in touch with us now for a live demo. www.veriflow.net/demo/
Contact us to see how Veriflow can protect your network.
sales@veriflow.net or call (408) 809-1790
Better data is becoming available on economic activity within countries, often much exceeding the available information of economic activity across countries. This creates new research opportunities for testing economic theory, analyzing market structures and the sources of market segmentation, and making predictions of how economic shocks propagate across space. The aim of this conference is to bring together researchers from urban economics, industrial organization, health economics, and international trade to study production and trade within and across countries.
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
playing with some new ideas involving desktop segmentation over time... tracking usage... public information & sharing....
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
Segmentation board game
A hands-on, interactive game that allows stakeholders to engage and empathise with their target customers by putting segments into real life situations to explore different scenarios and contexts.
20. November 2019, Jugendstilhƶrsaal der MedUni Wien
āMultiparametic Diagnostics and Theranostics of Tumorsā
Fabian Kiessling, UniversitƤtsklinikum Aachen
Abstract:
Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissuesā morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.
In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various āhallmarks of cancerā using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.
The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.
(c) MedUni Wien / Kovic
Capturing data is at the core of almost all digital health companies, representing unprecedented opportunities. Presumably, health data enables powerful analytics. But how can health analytics directly grow your company beyond improving market segmentation, efficiencies and cost-effectiveness/benefit analyses?
As the consumer market becomes flooded with data and analytics, digital health will level the playing field between consumers and traditional stakeholders in healthcare. This critical master class will discuss how your company can lead digital health and turn transparency into value-add, actionable results to nurture engagement and trust among your ultimate customers ā all of us, health consumers.
With over twenty years of experience in academic medicine and scientific research, Dr. Yao will share her vision of how scientific research, IT, and business processes can be integrated to move health analytics from being an efficiency-driver at best to the front line as product offerings to improve health. In her current role as CEO of Univfy, Dr. Yao has led both scientific and business fronts from founding of the company to the launch of health analytics on both consumer and business platforms to international and US customers.
Mylene Yao, MD, Co-founder and CEO,UNIVFY Inc. @MyleneYao
"http://summersummit.digitalhealthsummit.com/ - The Digital Health Summer Summit takes a deep dive into what it takes to build a successful digital health venture. It's a unique opportunity for entrepreneurs (and intrapreneurs) to hear industry veterans and key industry players share their lessons learned and best practices.
Official Hashtag: #DigiHealthSD
Digital Health Summit Website: bit.ly/DigitalHealthWebsite
Summer Summit Website: bit.ly/DigitalHealthSummer
Twitter: bit.ly/DigitalHealthTwitter
YouTube: bit.ly/DigitalHealthYouTube
Flickr: bit.ly/DigitalHealthFlickr
Linkedin: bit.ly/DigitalHealthLinkedIn
Facebook: bit.ly/DigitalHealthFB
Google+: bit.ly/DigitalHealthGPlus
Instagram: bit.ly/DigitalHealthInstagram
"