Entry in category 4. Video loop; Copyright CC-BY-NC-ND: Cindy Reinger

The video shows a 3D animation of the fruit fly, Drosophila melanogaster, which was scanned with micro-computed X-ray tomography (µ-CT).

Since its successful adaption to insects, this imaging technique offers a new accessible method for non-invasive imaging of Drosophila at high resolution. Besides embryos, larvae and adult flies, also flies at pupation can be scanned. Thanks to this breakthrough, the dynamic and important stages of metamorphosis can be easily studied at the whole organism level. µ-CT offers new possibility on the organ level as well. Using µ-CT, it is now possible to quantify tissue shape, size and volume, general morphology, inter-organ relationships and acquiring nice 3D imaging segmentation.

We are currently using µ-CT to study the complex remodelling processes of the gut during metamorphosis in wild-type and mutant backgrounds and the resulting consequences for the adult intestine.

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

This is a Sacramentary leaf with Insular style decoration that was probably made in Northern Germany (the Rhineland) in the first half of the tenth century.

The text consists of prayers and Benedictions and ending with a Lection followed by a Benediction. The Texts are: -

A prayer at the fireplace “Omnipotens sempiterne deus cuius sapientia”;

A prayer entering the hall “Via secundum omnium Iesu Christi”;

A blessing of the fruit “Te deprecamur, omnipotens deus”;

A blessing of the trees “Deus qui huius arboris poma”;

Another blessing (could be a blessing of the salt) “ Sancte Domine creator omnium creaturarum”;

Another blessing (could be another blessing of the salt) “ Domine sancte pater omnipotems aeterne deus”;

A blessing of the soap “Summe deus qui ima et media summaque”;

First Lection of Feria IIII in the month of December, a Lection from the Prophet Isaiah “In diebus illis. Loqui est Ahaz dicens”; and

A blessing of the candles at the Purification of the Blessed Virgin Mary “Domine Deus omnipoieus qui hodierna die legalia sacrificia”.

There are 33 lines on the recto but only 29 on the verso (one line unwritten before the Lection and three lines unwritten at the bottom of the page) in a superb Carolingian minuscule in brown and with rubric in red rustic capitals.

The leaf is not illuminated but it is decorated.

There are nine large initials and whilst generally set against one line they are large enough to be classified as two-line initials. On the recto, the initials are: -

An “O” composed of outer and inner rings and segmentation all in dark brown with most of the segments in-filled in ochre.

A “V” in red, the left arm crenelated and the right arm partly in-filled in ochre.

A “T” outlined in dark brown and in-filled in orange.

A “D” outlined in red, the left side in-filled in ochre, a red line through the top and the remainder of the abbreviated word within the body of the initial.

An “S” outlined in dark brown in-filled at the terminals in the same colour and in the centre in orange.

On the verso the initials are: -

A “D” outlined and segmented in dark brown, the upper terminal crenelated and tipped with red, the centre segment of the bowl in-filled with ochre.

Three initials, “S”, “I”, and “D” in red.

ALL THE INITIALS ON THE RECTO AND THE TOP INITIAL “D” ON THE VERSO DISPLAY DISTINCT INSULAR INFLUENCES.

The overall size of the leaf is 300mm x 225mm (11 8/10ins. x 8 17/20ins.).

OVERALL CONDITION: -

The leaf has been used to cover a book. Because of this, the recto is clean and bright and most of the verso is quite dirty. There are two quite severe creases, one in the bottom margin and one towards the outside of the leaf about 1ins. into the text. There are some small holes within these creases and some letters are lost because of the vertical crease. There are some losses of vellum to the inside and outside margins as well as there being a large piece missing at the bottom outside corner.

GENERAL COMMENTS: -

Despite its condition, the problems of which are not too severe, this is a wonderful leaf to have in any collection. The script is quite superb and the Insular elements to the initials are very seldom found on manuscripts that are offered for sale. The nature of the prayers and blessings would indicate that the leaf is from a monastic manuscript. In reference material that is available to me, I have found only two items with initials in a similar style as here. One is a bifolium (Lot 8, Sotheby's June 1997) from St. Amand (on the border of Flanders and Artois) and dated to early ninth century which I think is too early for this leaf. The other is a Sacramentary leaf (Item 26, Bernard Quaritch, Catalogue 1147, 1991) from Belgium or the Rhineland and dated to mid-tenth century. Not only does this date seem more realistic than early ninth century but the formation of the letter”g” is the same on both my leaf and the Quaritch leaf. It is because of this that I have given this leaf the heading that I have.

As we try to segment within the shifting tech tides of the social web, we find ourselves locked in a Platypus Paradox. Except this beast won't stop swimming long enough for us to establish it's taxonomy.

2015 Skoll World Forum

Twitter Audience Segmentation

Note that Bay Area respondents who want transit accessibility by and large are unconcerned with schools, but very concerned with (a) being close to SF and (b) not spending time in traffic. In fact, people worried about schools are pretty car-oriented.

Two potential conclusions:

1. School quality and neighborhood "nice"ness are not that important when marketing transit oriented locations

2. The market for TOD is difficult to disentangle from the market for *core locations* in general. People who want to live in TODs want to live near the core, in neighborhoods that allow them to minimize travel. They do not want low-amenity locations distant from the core but near transit. This bodes ill for suburban centers that are trying to become hip.

by Cambridge Systematics for MTC, 2008, at www.mtc.ca.gov/planning/smart_growth/tod/5-10/Market_Segm...

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

for women, driven by women. I take the metro at night all the time,

but I would never take a taxi at night other than a hotel taxi and

now....PinkTaxi.

Murat Mayor, PhD

MAYOR GROUP, mayorgroup.com

MAYOR STRATEGY, mayorstrategy.com

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

During the Pennsylvanian Period (305 million years ago) this area of Illinois was covered with coastal swamps, deltas, and upland forests situated along an estuary bay. The Field Museum’s collection of Mazon Creek fauna is the most comprehensive collection of these fossils anywhere. Many of the fossils are unique and found nowhere else in the world. Ironstone concretions preserved many soft-bodied animals and plants that are rarely fossilized.

In the near future the database with these specimens will be available online to researchers, K–12 students and teachers, and the general public. The specimen (PE 10504) in these two photos is the holotype of the “Tully Monster” (Tullimonstrum gregarium)—the state fossil of Illinois. Note how the image on the right, taken with polarized light, highlights the segmentation or striping, the eye, the eye-bar, the proboscis crossing over the body, and stylets (teeth-like elements) in the “jaw” or “claw.”

Nicole Karpus, paleontology collections intern, has finished digitizing 256 Mazon Creek holotypes, and figured specimens, as part of the Grainger Digital Initiative. Each fossil specimen was photographed twice, once with low-angle lighting and a second time with polarized light, which helps bring out the contrast between the fossil and the rock matrix.

To see additional specimens and to learn more about the Tully Monster check out This Field Revealed video at:

fieldmuseum.org/explore/multimedia/video-tully-monster

(c) The Field Museum, Paul Mayer

Geodemographic Profiles and Their Effects Towards Adult Health and Disease Rates

Supervisor: Dr. Evan Cleave

Theme: Social and Health Geography

Location: Toronto

Various studies have shown that there can be ever-looming disparities in health rates between various individuals solely based upon socioeconomic factors. Those who are considered the least well off oftentimes tend to require the most care due to the daily struggles of living in poverty. Moreover, many of these socio-economic inequalities can make it more difficult for an individual to acquire aid simply due to a lack of resources and time. Significantly, it has been theorized that individuals who possess higher social capital have a greatly likelihood of having better health outcomes, through positive social norms, networks, support, and the availability of strong organizational processes.

Thus, it can be extremely important and relevant for health officials and government decision makers to understand the disparities that socio-demographic variables can have towards a community’s overall health and wellbeing. By prioritizing groups who are socially defined as higher risk (based upon socioeconomic factors), proper resources and plans can be enacted to reduce inequalities in healthcare and reduce disease rates.

The following poster provides a general glimpse towards health rates in the 140 neighborhoods in the City of Toronto, paying specific attention to diabetes, asthma, and high blood pressure. The goal of this study is to determine how socio-demographic variables impact these health rates. It is hypothesized that socio segmentations with higher social capital (i.e. annual income, education rates, employment status), higher paying employment industries, and lower visible minority rates will have better health and lower disease rates.

Shakhrisabz is, above all, associated with the Ak-Saray palace. Many amazing legends are linked with the history of the palace's construction. According to one of them, Timur began to think of building a magnificent edifice, summoned an architect and set out his objective. After listening to the ruler, the architect asked to be allowed into the state exchequer. When permission was granted, the craftsman started to make foundation blocks from clay mixed with gold in full view of Timur.

Seeing that the ruler remained impassive, he broke up the blocks and returned the gold to the exchequer. When Timur asked: "Why did you do that?" the architect replied: "So as to make sure of your determination to embark on constructing a building that requires vast expenditure." A second legend recounts that, after the main building work had been completed, Timur began to tell the craftsmen to hurry up and finish the decorative facing of the palace. But they were in no hurry to cover the building with majolica and mosaic. When the angry ruler ordered the chief architect to be brought before him, it emerged that had vanished after hanging a chain in the centre of the palace's main arch. Since no other craftsman of equal stature could be found, the building remained unfinished. Some time later, however, the architect suddenly appeared and, after making sure that the chain on the entrance arch was now considerably lower, embarked on decorating the building.

When Timur demanded an explanation of his strange flight and sudden reappearance, the architect replied: "I dared not disobey my sovereign's command, but I could not carry it out either. Stern punishment awaited me in either case, since such a majestic building had to settle and bed down firmly in the ground, otherwise all the decoration on it would be destroyed." The great ruler appreciated the craftsman's wisdom and resourcefulness.

The palace building in Shahrisabz took over a quarter of a century to construct. The Spanish ambassador, Ruy Gonzalez de Clavijo, who passed through Shahrisabz in 1404 on his way to the court of Timur in Samarkand, was astounded and charmed by the architectural miracle, and he left a detailed description of it, noting, however, that the splendid artistic decoration of the palace was still unfinished. The overall layout, scale and artistic appearance of Ak-Saray can be reconstituted from the descriptions of contemporaries and eyewitnesses, as well as from the results of archaeological excavation at the site. According to written accounts, the palace consisted of several stately, living or service quarters, grouped around separate courtyards.

The overall scale of the palace is impressive: the main courtyard alone, which has been reconstituted from the micro relief, was 120 - 125 m wide and 240 - 250 m long. The size of the other courtyards and of the outer perimeter of the palace has not been reconstructed owing to severe disturbance of the micro relief in the 15th - 16th centuries. Calculation of the proportions of the surviving elements of the site makes it fairly certain that the height of the main portal reached 70 m. It was topped by arched pinnacles (ko'ngra), while corner towers on a multifaceted pedestal were at least 80 m high. The main entrance portal was 50 m wide, and the arch had the largest span, 22.5 m, in Central Asia.

The architectural decor, featuring a wide variety of designs and colours, is particularly noteworthy in the artistic appearance of Ak-Saray. When using various techniques, however, the craftsmen bore in mind that the palace's main portal faced north, towards the capital, Samarkand. Given the poor light, the architects used only flat segmentation here and hence a continuous decorative treatment. The use of brick mosaic work, mainly dark and light blue in colour, forming large geometrical and epigraphic designs on a background of polished building brick, gives the portal a special softness of colour and an air of grand mystery.

The various mosaic and majolica work in the niche of the portal is particularly refined and highly coloured. The delicately executed ornamentation incorporates exquisite calligraphic inscriptions of mainly Koranic content, although secular ones are found too. In the midst of the decorative facing, an inscription has survived, giving the date of completion, 798 (1395 - 1396), and the name of the craftsman, Muhammad Yusuf Tebrizi (from the Azeri city of Tabriz). According to Clavijo, who visited Ak-Saray, "in this palace was a very long entrance and a very high portal, and by the entrance, to right and left, were brick arches covered with tiles painted with various designs. Beneath these arches was what looked like small rooms without doors, and the floor inside them was covered with tiles. This was done so that people could sit there when the king was present. Beyond this was another door and after that a large courtyard, paved with white slabs and surrounded by richly decorated galleries. In the middle of the courtyard was a large pool. The courtyard was some 300 paces wide, and it gave access to a large house, in which was a very high and wide door, decorated with gold, azure and tiles of very fine workmanship. In the middle, above the door, a lion was depicted, lying in the sun, and exactly the same picture was to be found at the edges. This was the device of the king of Samarkand. After this, the envoys were taken to look at the chamber that the king had appointed for sitting and feasting with his wives, very spacious and luxurious. Before it was a large garden with many shady and assorted fruit trees. Inside it were many pools and artfully sited meadows. By the entrance to this garden there was such a vast space that many people could have enjoyed themselves sitting there in the summertime beside the water and beneath the shade of the trees. The workmanship in the palace is so luxurious that, in order to describe everything well, one has to go and examine it a little at a time."

The Ak-Saray palace is a grandiose piece of civil architecture, and not just by Central Asian standards. Historical tradition ascribes the destruction of the majestic edifice to Abdullakhan, who, during one of the sieges of un-subdued Shahrisabz, is supposed to have ordered the splendid structures of Timur and his descendants to be demolished. Be that as it may, of the once luxurious royal palace only the pillars and part of the arch of the main portal remained by the second half of the 18th century.

works fairly well for static images.

Emma Macdonald, presenting "Multi-Touchpoint Customer Segmentation in Relational Contexts: Using a Real-Time Experience Tracking Approach"

Frank Lloyd Wright. p. 78 in: RASMUSSEN, Steen Eiler (1959). Experiencing Architecture. Chapman & Hall, London.

---

Johnson Wax Headquarters is the world headquarters and administration building of S. C. Johnson & Son in Racine, Wisconsin. Designed by American architect Frank Lloyd Wright for the company's president, Herbert F. "Hib" Johnson, the building was constructed from 1936 to 1939. Also known as the Johnson Wax Administration Building, it and the nearby 14-story Johnson Wax Research Tower (built 1944–1950) were designated as a National Historic Landmark in 1976 as Administration Building and Research Tower, S.C. Johnson and Son.

The Johnson Wax Headquarters were set in an industrial zone and Wright decided to create a sealed environment lit from above, as he had done with the Larkin Administration Building. The building features Wright's interpretation of the streamlined Art Moderne style popular in the 1930s. In a break with Wright's earlier Prairie School structures, the building features many curvilinear forms and subsequently required over 200 different curved "Cherokee red" bricks to create the sweeping curves of the interior and exterior. The mortar between the bricks is raked in traditional Wright-style to accentuate the horizontality of the building. The warm, reddish hue of the bricks was used in the polished concrete floor slab as well; the white stone trim and white dendriform columns create a subtle yet striking contrast. All of the furniture, manufactured by Steelcase, was designed for the building by Wright and it mirrored many of the building's unique design features.

The entrance is within the structure, penetrating the building on one side with a covered carport on the other. The carport is supported by short versions of the steel-reinforced dendriform (tree-like) concrete columns that appear in the Great Workroom. The low carport ceiling creates a compression of space that later expands when entering the main building where the dendriform columns rise over two stories tall. This rise in height as one enters the administration building creates a release of spatial compression making the space seem much larger than it is. Compression and release of space were concepts that Wright used in many of his designs, including the playroom in his Oak Park Home and Studio, the Unity Temple in Oak Park, Illinois, the Solomon R. Guggenheim Museum in New York City, and many others.

Throughout the "Great Workroom," a series of the thin, white dendriform columns rise to spread out at the top, forming a celling, the spaces in between the circles are set with skylights made of Pyrex glass tubing. At the corners, where the walls usually meet the ceiling, the glass tubes continue up, over and connect to the skylights creating a clerestory effect and letting in a pleasant soft light. The Great Workroom is the largest expanse of space in the Johnson Wax Building, and it features no internal walls. It was originally intended for the secretaries of the Johnson Wax company, while a mezzanine holds the administrators.

The construction of the Johnson Wax building created controversies for the architect. In the Great Workroom, the dendriform columns are 9 inches (23 cm) in diameter at the bottom and 18 feet (550 cm) in diameter at the top, on a wide, round platform that Wright termed, the "lily pad." This difference in diameter between the bottom and top of the column did not accord with building codes at the time. Building inspectors required that a test column be built and loaded with twelve tons of material. The test column, once it was built, was tough enough that it was able to be loaded fivefold with sixty tons of materials before the "calyx," the part of the column that meets the lily pad, cracked (crashing the 60 tons of materials to the ground, and bursting a water main 30 feet underground). After this demonstration, Wright was given his building permit.

Additionally, it was very difficult to properly seal the glass tubing of the clerestories and roof, thus causing leaks. This problem was not solved until the company replaced the top layers of tubes with skylights of angled sheets of fiberglass and specially molded sheets of Plexiglas with painted dark lines to resemble the original joints. And finally, Wright's chair design for Johnson Wax originally had only three legs, supposedly to encourage better posture (because one would have to keep both feet on the ground at all times to sit in it). However, the chair design proved too unstable, tipping very easily. Herbert Johnson, needing a new chair design, purportedly asked Wright to sit in one of the three-legged chairs and, after Wright fell from the chair, the architect designed new chairs for Johnson Wax with four legs; these chairs, and the other office furniture designed by Wright, are still in use.

Despite these problems, Johnson was pleased with the building design, and later commissioned the Research Tower, and a house from Wright known as Wingspread.

The Research Tower was a later addition to the building. Cantilevered from a giant stack, the tower's floor slabs spread out like tree branches, providing for the segmentation of departments vertically. Elevator and stairway channels run up the core of the building. The single reinforced central core, termed by Wright as a tap root, was based on an idea proposed by Wright for the St. Mark's Tower in 1929. Wright recycled the tap root foundation in the Price Tower in Bartlesville, Oklahoma in 1952. Freed from peripheral supporting elements, the tower rises gracefully from a garden and three fountain pools that surround its base while a spacious court on three sides provides ample parking for employees.

The Research Tower is no longer in use because of the change in fire safety codes, although the company is committed to preserving the tower as a symbol of its history.

The Johnson Wax buildings are on the National Register of Historic Places, and the Administration Building and the Research Tower were each chosen by the American Institute of Architects as two of seventeen buildings by the architect to be retained as examples of his contribution to American culture. In addition, the Administration Building and Research Tower were both designated National Historic Landmarks in 1976.

In 2008, the U.S. National Park Service submitted the Johnson Wax Headquarters and the Research Tower, along with nine other Frank Lloyd Wright properties, to a tentative list for World Heritage Status. The 10 sites have been submitted as one total site. The January 22, 2008 press release from the National Park Service website announcing the nominations states that, "The preparation of a Tentative List is a necessary first step in the process of nominating a site to the World Heritage List."

As of Spring 2013, many parts of the building, including the carport and Research Tower are undergoing extensive restoration work. (Wikipedia)

Three Legged Cross, Dorset

COLLEMBOLA (Springtails) > ENTOMOBRYOMORPHA > Entomobryidae > Orchesellinae > Orchesella cincta

____________________________________________________

Hidden Worlds

COLLEMBOLA were previously classified with insects, but are now treated as a class in their own right, sitting alongside DIPLURA (the Two-pronged Bristletails) and PROTURA (Proturans or Coneheads). They are the wingless ARTHROPODS, which together with INSECTA are the four classes within the superclass HEXAPODA.

Springtails, the most abundant arthropods on earth, are very small wingless creatures, just a few millimetres long that live mainly in soil and leaf litter. They are so named due to their forked springing organ, or furca, which enables them to jump considerable distances of up to several centimetres when disturbed. They have reduced eyes, variable length antennae, simple bodies and short legs. They have two distinct forms; elongate in which the six abdomen segments are clearly visible, and globular bodies where the segmentation is far from apparent. There are around 250 species in Britain, the majority of which are so small that I wouldn’t even attempt to photograph them. However, there are a few in the 2-5mm range that are of interest and over the past few weeks I have managed to get some reasonable photos of some of them.

This is Orchesella cincta, which without doubt is the most common species that I find in the garden. They are one of the larger species reaching 5mm in length.

LG PC segmentation - one that is obscured in the middle is: Tab-Book Ultra

Ce jeudi, il devait faire beau, le matin, temps superbe, à 11 h, moche … Et météo de retour pessimiste, annonçant un ciel complètement plombé. Je suis néanmoins allé à Brest . Nuages opaques et continus, et finalement le soleil apparaît et joue, plutôt facétieux, avec un joli ciel de traine .

Pour ce qui est de l'engin jaune et argent, je n'ai pas été déçu, je l'ai vu et vu encore . Reste à y monter .

Rue de Maissin .

Brest, Finistère, Bretagne, France .

Photographie Jean-Patrick Leroy, droits réservés .

If societies are to thrive, not just survive, there must be a set of common values that undergird social and governmental interactions. Values are often derived from religion, yet there is deep misunderstanding among and between people of different faith (and no faith) backgrounds, which can threaten the social cohesion of communities. Our times suggest that values may not be common—within or across groups—and that religions are being manipulated (sometimes by governments) for the benefit of majority groups. This has led towards increased segmentation and polarization in societies, which has been exploited by those seeking to foment division.

Property of the Aspen Institute / Photo Credit: Laurence Genon

playing with some new ideas involving desktop segmentation over time... tracking usage... public information & sharing....

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

Cikuan Bra fishtail wedding, suffused with a soft sheen satin belt with good visual segmentation add layering, simple fishtail skirt lined sketched out the bride graceful posture, nestled in the tissue, akinds of the looming beauty, particularly sultry.

(Further pictures you can see quite easily by clicking on the link at the end of page!)

Vienna 1, The Franciscan Church

The Franciscans go back to St. Francis of Assisi and thus the 13th Century. They were founded as a mendicant orders but soon the arose the question how literally one should take the declaration of poverty. Was it allowed to make financial provision for elderly or sick brothers? Finally it came to the segmentation of the faith community, the more liberal Minoriten (Friars Minor Conventual) made ​​their own order, while the Franciscans followed the old conventions. 1453 came the first Franciscan, John of Capistrano, to Vienna.

He founded the first Franciscan monastery in what is now 6th District. But the monks had to flee when the Turks besieged Vienna in 1529 and the monastery burned down. It took until 1589 until the city of Vienna gave them the at that time vacant monastery together with appendant church. The house, in its place now stands the monastery had already been donated in 1306 by wealthy citizens - namely for "loose women" who wanted give up their trade and convert themselves.

1476 was at the Weichenburg (hence Weihburggasse) inaugurated a church with seven altars, where formerly a "Pfarrheusl (small parsonage)" had stood for the soul welfare of the female residents. At the time of the Reformation, however, moral values in this house went downhill. 1553, the Foundation was dissolved, but it took yet until 1572 before the last resident had died. For eight years, the building was then an educational establishment for girls of poor people.

When the Franciscans now had got the property, they started in 1603 with a reconstruction of the church, which was consecrated in 1611. 1614, the foundation stone was laid for the new monastery.

The statues on the west facade are left Francis of Assisi and Anthony of Padua right. In the middle, on the pediment of the west portal of the Church stands Jerome, protector of the church. He is surrounded by two angle putti.

But let's go inside the church. Maria with the ax is the altarpiece above the high altar. The statue was carved in 1505 from lime wood and has its own story. She comes from the Green Mountain (Grünberg) in Bohemia, which was under the control the Sternberg family. Since the family in the meantime had become Protestant, it wanted to burn the statue. She were thrown into the fire - but the next day she stood unharmed again in the chapel. Now, the executioner was called who should dismember the effigy. However, even that was impossible, because the ax stuck in the shoulder of Mary and it was not possible to get it out. There it is still today. (You have to look closely, but then you see the great ax with slightly curved stem.) But that's not enough. A few years later the Madonna was lost in the gamble by a gegenreformierten (counter-reformed) Sternberg. The new owner, the Polish Baron Turnoffsky gave she in 1607 the Franciscan monastery. Exactly 100 years later, she got her current stand on the high altar.

The stone structure between altar and the statue of the Madonna also contains a crucifix, which dates from the beginning of the 17th Century. The wooden statues left and right represent the Saints Jerome respectively Francis and are typical examples of the so-called Franciscan carving school. It operated 1690-1730 and was run by lay brothers. The overall concept for the high altar dates back to the Jesuit Andrea dal Pozzo.

A special attraction is the organ by Hans Wöckherl that was already built in 1642 and today is the oldest organ in Vienna. It is, however, disappeared from the visible church, because it is behind the high altar and is only shown every Friday between 15.00 und 15.30 clock. In addition, one demans for that six euro entry...

The single-nave church has to both sides side chapels, of them I want to show two.

On the left we see the Magdalene Chapel, which was consecrated already in 1614 for the first time. 1644 and 1722, however, followed ​​Neustiftungen (new foundings). The stucco decoration stems from 1644. The paintings in the vault are much more recent, from 1893. The altarpiece depicts the grieving Mary Magdalene under the Cross. It was created in 1725 by Carlo Innocenzo Carlone. The image above shows Veronica's handkerchief with the face of Christ. It was painted by Wolfram Koeberl and in 1974 installed. The statues beside the altar represent the Virgin Mary and John the Baptist. The two above chapels are provided with food grid, so that one could give Communion here.

An Immaculata chapel (pictured above right) is there since the existence of the church, but this was rebuilt in 1722. Previously, since 1642, there was a Michael altar here. From this period dates still the stucco decor on the ceiling. The altarpiece is by Johann Georg Schmidt, who painted it in 1721. The lateral statues depict the Saint Joachim and the mother of Mary.

Also the Capistrano Chapel, which was founded in 1723, is worth mentioning. The lateral stucco decor shows on the left side (picture) the glorification of St. John Capistrano, who, as I said, was the first Franciscan in Vienna. Right you can see him as a standard-bearer of Christian doctrine in the wars against the Turks. Both stucco images date from the time of the foundation. The altarpiece by Franz Xaver Wagenschön originated in 1761 and shows Capistrano in a scene from 1451, in Brescia when he healed a possessed man.

In the picture we see also the statue of Saint George, as he is killing the (admittedly small) dragon.

On the other side of the chapel is the Holy Florian, while Clara and Theresa stand next to the altar. Behind the altar there is a reliquary in glass from about 1720, in which we see a wax image of the Holy Hilaria. The relic shall be imbedded in the wax. Hilaria is rather unknown, but she was a martyr who was converted by Bishop Narcissus. She died in the year 304 in Augsburg, at the behest of the governor Gaius, because she did not want to renounce the Christian faith. About the nature of death, there are different opinions.

In the church there is a plaque that claims that she was burned at the grave of her daughter, while the Holy Encyclopedia states that she was enclosed in her house and this was then set on fire.

In the chapel opposite, the Chapel of the Good Shepherd, there is also a glass coffin with a relic. This is the skeleton of the Felix Puer wearing the uniform of a Roman Centurion.

As a counterpart to the pulpit, this just opposite, you will find the monument of Johann Nepomuk. We see how he flows on the water of the Vltava river after he was thrown in Prague there. He actually was called "John from Nepomuk" in Czech "ne Pomuk". The wife of Emperor Wenceslas IV is said to have chosen him as confessor. The Emperor wanted to know then what she had confessed, but Johann Nepomuk did not betray the seal of confession and was therefore thrown into the water. The Empress had then an appearance of five stars.

(We see she also in the water of the monument.) These stars indicated were one could find the body. So much for the legend.

The fact is that Johann Nepomuk was tortured by the king and thrown into the Vltava. The activating moment was a dispute over a new monastery between the emperor and the archbishop of Prague, in which John Nepomuk was trampled underfoot ...

The pulpit was built in 1726 and was executed by the Franciscan carving school. At the parapet there are wooden reliefs of Matthew, Mark and Luke. The relief of the fourth evangelist, John, is attached to the pulpit door. At the parapet you further can see statues of Capistrano and Bonaventura, while on the sounding board are sitting Anthony of Padua and Berhardin of Siena. At the top stands the freeze image of Francis of Assisi.

The pews were 1727 - 1729 by brother Johann Gottfried Hartmann built and carved.

www.werbeka.com/wien/wien4/franzisd.htm

* Co-responsible for the selection of Spanish materials, adults and children, for the Free Library of Philadelphia System

* Establishing contact with publishers & vendors

* Professional development & networking

* Interview for America Reads Spanish TV: Promoting Spanish library services in the United States market. Find video at www.americareadsspanish.tv/

* Participation in the America Reads Spanish Translation Project Spring/ Summer 2012. Find additional information at www.americareadsspanish.org/translation-rights/nsb-titles...

Bad Hard Drive

Employing a CT scanner, Museum curator in the Division of Paleontology John Maisey can observe how calcified tissue builds up to form the braincase of a modern shark. Tiny, dense tiles of calcium minerals line the cartilage in order to stiffen it. These tiles are shown in gold in this large image, generated using volume rendering and density segmentation software. Maisey uses this information to compare braincases of modern and ancient sharks.

© AMNH\J. Maisey

I think this may be an aquatic fly larva. I placed 2 of these on a petri-dish in a thin layer of water from the wheelbarrow. I will try to rear them to adulthood. I have attempted to label what I recognize in the image.

Cikuan Bra fishtail wedding, suffused with a soft sheen satin belt with good visual segmentation add layering, simple fishtail skirt lined sketched out the bride graceful posture, nestled in the tissue, akinds of the looming beauty, particularly sultry.

All this store needs are category signs above each section to make it easier for shoppers; shoes, saddles, womens, mens, etc

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

Hello ~! I go by woo jun lee. I'm a student of International Trade & Business at Hanseo University. I took a picture of marketing Principle. Is there anyone who know this textbook? Do you took a class with me last year? Ok. So, Let me introduce marketing simply. Before a company sells a product, they consider how the product sells, how the product promotions. They also have to set up STP for product. STP means segmentation, targeting and positioning. And the the company releases the product. Right! This is marketing!! I give you one question. Do you think what's iPhone's image? Um.. This is... Creative and simple! Yes, right! This is iPhone's positioning that you say. What do you think? Is marketing interested in? But marketing professor is so crazy man. You know? You know? You know? In class hour, he ask us something. And he says, " you!! Your eyes is twinkle twinkle !! " like you know everything. I hate professor!! I don't sleep, he says you get out ! Also, there is much homework! Anyway, I hate him, but I love marketing, very interesting for me. I hope you do too.

(Further pictures you can see quite easily by clicking on the link at the end of page!)

Vienna 1, The Franciscan Church

The Franciscans go back to St. Francis of Assisi and thus the 13th Century. They were founded as a mendicant orders but soon the arose the question how literally one should take the declaration of poverty. Was it allowed to make financial provision for elderly or sick brothers? Finally it came to the segmentation of the faith community, the more liberal Minoriten (Friars Minor Conventual) made ​​their own order, while the Franciscans followed the old conventions. 1453 came the first Franciscan, John of Capistrano, to Vienna.

He founded the first Franciscan monastery in what is now 6th District. But the monks had to flee when the Turks besieged Vienna in 1529 and the monastery burned down. It took until 1589 until the city of Vienna gave them the at that time vacant monastery together with appendant church. The house, in its place now stands the monastery had already been donated in 1306 by wealthy citizens - namely for "loose women" who wanted give up their trade and convert themselves.

1476 was at the Weichenburg (hence Weihburggasse) inaugurated a church with seven altars, where formerly a "Pfarrheusl (small parsonage)" had stood for the soul welfare of the female residents. At the time of the Reformation, however, moral values in this house went downhill. 1553, the Foundation was dissolved, but it took yet until 1572 before the last resident had died. For eight years, the building was then an educational establishment for girls of poor people.

When the Franciscans now had got the property, they started in 1603 with a reconstruction of the church, which was consecrated in 1611. 1614, the foundation stone was laid for the new monastery.

The statues on the west facade are left Francis of Assisi and Anthony of Padua right. In the middle, on the pediment of the west portal of the Church stands Jerome, protector of the church. He is surrounded by two angle putti.

But let's go inside the church. Maria with the ax is the altarpiece above the high altar. The statue was carved in 1505 from lime wood and has its own story. She comes from the Green Mountain (Grünberg) in Bohemia, which was under the control the Sternberg family. Since the family in the meantime had become Protestant, it wanted to burn the statue. She were thrown into the fire - but the next day she stood unharmed again in the chapel. Now, the executioner was called who should dismember the effigy. However, even that was impossible, because the ax stuck in the shoulder of Mary and it was not possible to get it out. There it is still today. (You have to look closely, but then you see the great ax with slightly curved stem.) But that's not enough. A few years later the Madonna was lost in the gamble by a gegenreformierten (counter-reformed) Sternberg. The new owner, the Polish Baron Turnoffsky gave she in 1607 the Franciscan monastery. Exactly 100 years later, she got her current stand on the high altar.

The stone structure between altar and the statue of the Madonna also contains a crucifix, which dates from the beginning of the 17th Century. The wooden statues left and right represent the Saints Jerome respectively Francis and are typical examples of the so-called Franciscan carving school. It operated 1690-1730 and was run by lay brothers. The overall concept for the high altar dates back to the Jesuit Andrea dal Pozzo.

A special attraction is the organ by Hans Wöckherl that was already built in 1642 and today is the oldest organ in Vienna. It is, however, disappeared from the visible church, because it is behind the high altar and is only shown every Friday between 15.00 und 15.30 clock. In addition, one demans for that six euro entry...

The single-nave church has to both sides side chapels, of them I want to show two.

On the left we see the Magdalene Chapel, which was consecrated already in 1614 for the first time. 1644 and 1722, however, followed ​​Neustiftungen (new foundings). The stucco decoration stems from 1644. The paintings in the vault are much more recent, from 1893. The altarpiece depicts the grieving Mary Magdalene under the Cross. It was created in 1725 by Carlo Innocenzo Carlone. The image above shows Veronica's handkerchief with the face of Christ. It was painted by Wolfram Koeberl and in 1974 installed. The statues beside the altar represent the Virgin Mary and John the Baptist. The two above chapels are provided with food grid, so that one could give Communion here.

An Immaculata chapel (pictured above right) is there since the existence of the church, but this was rebuilt in 1722. Previously, since 1642, there was a Michael altar here. From this period dates still the stucco decor on the ceiling. The altarpiece is by Johann Georg Schmidt, who painted it in 1721. The lateral statues depict the Saint Joachim and the mother of Mary.

Also the Capistrano Chapel, which was founded in 1723, is worth mentioning. The lateral stucco decor shows on the left side (picture) the glorification of St. John Capistrano, who, as I said, was the first Franciscan in Vienna. Right you can see him as a standard-bearer of Christian doctrine in the wars against the Turks. Both stucco images date from the time of the foundation. The altarpiece by Franz Xaver Wagenschön originated in 1761 and shows Capistrano in a scene from 1451, in Brescia when he healed a possessed man.

In the picture we see also the statue of Saint George, as he is killing the (admittedly small) dragon.

On the other side of the chapel is the Holy Florian, while Clara and Theresa stand next to the altar. Behind the altar there is a reliquary in glass from about 1720, in which we see a wax image of the Holy Hilaria. The relic shall be imbedded in the wax. Hilaria is rather unknown, but she was a martyr who was converted by Bishop Narcissus. She died in the year 304 in Augsburg, at the behest of the governor Gaius, because she did not want to renounce the Christian faith. About the nature of death, there are different opinions.

In the church there is a plaque that claims that she was burned at the grave of her daughter, while the Holy Encyclopedia states that she was enclosed in her house and this was then set on fire.

In the chapel opposite, the Chapel of the Good Shepherd, there is also a glass coffin with a relic. This is the skeleton of the Felix Puer wearing the uniform of a Roman Centurion.

As a counterpart to the pulpit, this just opposite, you will find the monument of Johann Nepomuk. We see how he flows on the water of the Vltava river after he was thrown in Prague there. He actually was called "John from Nepomuk" in Czech "ne Pomuk". The wife of Emperor Wenceslas IV is said to have chosen him as confessor. The Emperor wanted to know then what she had confessed, but Johann Nepomuk did not betray the seal of confession and was therefore thrown into the water. The Empress had then an appearance of five stars.

(We see she also in the water of the monument.) These stars indicated were one could find the body. So much for the legend.

The fact is that Johann Nepomuk was tortured by the king and thrown into the Vltava. The activating moment was a dispute over a new monastery between the emperor and the archbishop of Prague, in which John Nepomuk was trampled underfoot ...

The pulpit was built in 1726 and was executed by the Franciscan carving school. At the parapet there are wooden reliefs of Matthew, Mark and Luke. The relief of the fourth evangelist, John, is attached to the pulpit door. At the parapet you further can see statues of Capistrano and Bonaventura, while on the sounding board are sitting Anthony of Padua and Berhardin of Siena. At the top stands the freeze image of Francis of Assisi.

The pews were 1727 - 1729 by brother Johann Gottfried Hartmann built and carved.

www.werbeka.com/wien/wien4/franzisd.htm

Shakhrisabz is, above all, associated with the Ak-Saray palace. Many amazing legends are linked with the history of the palace's construction. According to one of them, Timur began to think of building a magnificent edifice, summoned an architect and set out his objective. After listening to the ruler, the architect asked to be allowed into the state exchequer. When permission was granted, the craftsman started to make foundation blocks from clay mixed with gold in full view of Timur.

Seeing that the ruler remained impassive, he broke up the blocks and returned the gold to the exchequer. When Timur asked: "Why did you do that?" the architect replied: "So as to make sure of your determination to embark on constructing a building that requires vast expenditure." A second legend recounts that, after the main building work had been completed, Timur began to tell the craftsmen to hurry up and finish the decorative facing of the palace. But they were in no hurry to cover the building with majolica and mosaic. When the angry ruler ordered the chief architect to be brought before him, it emerged that had vanished after hanging a chain in the centre of the palace's main arch. Since no other craftsman of equal stature could be found, the building remained unfinished. Some time later, however, the architect suddenly appeared and, after making sure that the chain on the entrance arch was now considerably lower, embarked on decorating the building.

When Timur demanded an explanation of his strange flight and sudden reappearance, the architect replied: "I dared not disobey my sovereign's command, but I could not carry it out either. Stern punishment awaited me in either case, since such a majestic building had to settle and bed down firmly in the ground, otherwise all the decoration on it would be destroyed." The great ruler appreciated the craftsman's wisdom and resourcefulness.

The palace building in Shahrisabz took over a quarter of a century to construct. The Spanish ambassador, Ruy Gonzalez de Clavijo, who passed through Shahrisabz in 1404 on his way to the court of Timur in Samarkand, was astounded and charmed by the architectural miracle, and he left a detailed description of it, noting, however, that the splendid artistic decoration of the palace was still unfinished. The overall layout, scale and artistic appearance of Ak-Saray can be reconstituted from the descriptions of contemporaries and eyewitnesses, as well as from the results of archaeological excavation at the site. According to written accounts, the palace consisted of several stately, living or service quarters, grouped around separate courtyards.

The overall scale of the palace is impressive: the main courtyard alone, which has been reconstituted from the micro relief, was 120 - 125 m wide and 240 - 250 m long. The size of the other courtyards and of the outer perimeter of the palace has not been reconstructed owing to severe disturbance of the micro relief in the 15th - 16th centuries. Calculation of the proportions of the surviving elements of the site makes it fairly certain that the height of the main portal reached 70 m. It was topped by arched pinnacles (ko'ngra), while corner towers on a multifaceted pedestal were at least 80 m high. The main entrance portal was 50 m wide, and the arch had the largest span, 22.5 m, in Central Asia.

The architectural decor, featuring a wide variety of designs and colours, is particularly noteworthy in the artistic appearance of Ak-Saray. When using various techniques, however, the craftsmen bore in mind that the palace's main portal faced north, towards the capital, Samarkand. Given the poor light, the architects used only flat segmentation here and hence a continuous decorative treatment. The use of brick mosaic work, mainly dark and light blue in colour, forming large geometrical and epigraphic designs on a background of polished building brick, gives the portal a special softness of colour and an air of grand mystery.

The various mosaic and majolica work in the niche of the portal is particularly refined and highly coloured. The delicately executed ornamentation incorporates exquisite calligraphic inscriptions of mainly Koranic content, although secular ones are found too. In the midst of the decorative facing, an inscription has survived, giving the date of completion, 798 (1395 - 1396), and the name of the craftsman, Muhammad Yusuf Tebrizi (from the Azeri city of Tabriz). According to Clavijo, who visited Ak-Saray, "in this palace was a very long entrance and a very high portal, and by the entrance, to right and left, were brick arches covered with tiles painted with various designs. Beneath these arches was what looked like small rooms without doors, and the floor inside them was covered with tiles. This was done so that people could sit there when the king was present. Beyond this was another door and after that a large courtyard, paved with white slabs and surrounded by richly decorated galleries. In the middle of the courtyard was a large pool. The courtyard was some 300 paces wide, and it gave access to a large house, in which was a very high and wide door, decorated with gold, azure and tiles of very fine workmanship. In the middle, above the door, a lion was depicted, lying in the sun, and exactly the same picture was to be found at the edges. This was the device of the king of Samarkand. After this, the envoys were taken to look at the chamber that the king had appointed for sitting and feasting with his wives, very spacious and luxurious. Before it was a large garden with many shady and assorted fruit trees. Inside it were many pools and artfully sited meadows. By the entrance to this garden there was such a vast space that many people could have enjoyed themselves sitting there in the summertime beside the water and beneath the shade of the trees. The workmanship in the palace is so luxurious that, in order to describe everything well, one has to go and examine it a little at a time."

The Ak-Saray palace is a grandiose piece of civil architecture, and not just by Central Asian standards. Historical tradition ascribes the destruction of the majestic edifice to Abdullakhan, who, during one of the sieges of un-subdued Shahrisabz, is supposed to have ordered the splendid structures of Timur and his descendants to be demolished. Be that as it may, of the once luxurious royal palace only the pillars and part of the arch of the main portal remained by the second half of the 18th century.

Some sandstone in the Santa Cruz Mountains have variable levels of calcium carbonate segmentation resulting is certain parts being softer than others. The heavy rainfalls in our mountains contain carbon dioxide from the air which seeps into the sandstone and dissolves the softer areas of calcium carbonate holding the sand grains in place. During our dry season (we do have a short one,) the calcium carbonate is drawn to the rock's surface forming a deposit that resists erosion. This leaves the uncemented sand below to crumble away. The resulting caves and honeycomb formations are called tafoni.

There are three areas in the Santa Cruz Mountains, all off of Skyline Boulevard (Highway 35,) that are particularly known for their tafoni. The most well known is at Castle Rock State Park. The sandstone here is hard enough that climbing is allowed and on 80-foot high sandstone outcropping is particularly popular.

Across Skyline Boulevard from Castle Rock in Sanborn County Park their is Summit Rock. With an elevation of 3076 feet you can take in the tafoni along with a nice panorama view of the Silicon Valley. On the down side, there is some graffiti on Summit Rock probable. The county parks just aren't as well policed as state parks and the hike is short enough that slobs can find their way to deface this natural beauty.

The third area of noted tafoni is located in the El Corte de Madera Creek Open Space Preserve between Highway 92 and Woodside Road at Skegg's Point Caltrans Rest Stop. The rock is only 2.5 mile hike from Highway 35. However, the bad guys haven't discovered this area yet so please only tell your responsible friends. There are 33 miles of multi-use trains within this 2,821-acre preserve. The preserve was established to protect the headwaters of the San Gregorio Creek watershed that is critical habitat for steelhead trout and coho salmon. Therefore, certain trails have been closed to the public to enable restoration. Failure of visitors to respect these closures could easily result in the entire preserve being closed to the public. The sandstone at El Corte de Madera Creek is softer and more fragile than at places such as Castle Rock and climbing is not allowed here. The up side of the rock being more fragile is that the tafoni is more spectacular. So, we highly recommend this preserve to our responsible flickr photographer friends. The light at the sandstone is very filtered and I really needed to carry a sturdier tripod (I normally just have a Trekpod) and a strong external flash for flash fill. Next time I'm bringing these items along.

FDR-Control in Multiscale Change-point Segmentation. Li, Munk, Sieling arxiv.org/abs/1412.5844 #stat

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

matlab-recognition-code.com/personal-iris-recognition-usi...

Abstract

Having a neater life by the assistance of creating applied sciences forces individuals is extra difficult technological construction. In at present’s world, safety is extra essential than ever. Dazziling developments in know-how arouse curiosity of scientists about human and human behaviors and on the similar time, give a chance to individuals to use their ideas. Today, for safety wants, detailed researches are organized to arrange probably the most dependable system. Iris Recognition Security System is among the most dependable main applied sciences that most individuals are associated. Iris recognition know-how combines pc imaginative and prescient, sample recognition, statistical inference, and optics. Its function is actual-time, excessive confidence recognition of an individual’s id by mathematical evaluation of the random patterns which are seen inside the iris of an eye fixed from a long way. Because the iris is a protected inner organ whose random texture is secure all through life, it may function a type of dwelling passport or a dwelling password that one needn’t keep in mind however can all the time current. Because the randomness of iris patterns has very excessive dimensionality, recognition selections are made with confidence ranges excessive sufficient to help speedy and dependable exhaustive searches via nationwide-sized databases.

Artificial Neural Networks (ANNs) are packages designed to simulate the best way a easy organic nervous system is believed to function. They are based mostly on simulated nerve cells or neurons, that are joined collectively in quite a lot of methods to type networks. These networks have the capability to study, memorize and create relationships amongst knowledge. ANN is an info-processing paradigm, carried out in hardware or software program that’s modeled after the organic processes of the mind. An ANN is made up of a set of extremely interconnected nodes, referred to as neurons or processing parts. A node receives weighted inputs from different nodes, sums these inputs, and propagates this sum by way of a perform to different nodes. This course of is analogous to the actions of a organic neuron. An ANN learns by instance. In a organic mind, studying is completed because the strengths of the connections between nodes are adjusted. This is true for ANN’s additionally, as these strengths are captured by the weights between the nodes. ANN’s most necessary benefit is that they can be utilized to unravel issues of appreciable complexity; issues that would not have an algorithmic answer or for which such an answer is just too complicated to be discovered. Because of their abstraction from the mind, ANNs are good at fixing issues that people are good at fixing however which computer systems are usually not. Pattern recognition and classification are examples of issues which are nicely fitted to ANN software.

Keyword: Matlab, supply, code, iris, recognition, segmentation, detection, verification, matching, ann, nn, neural, community, networks.

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Habatat Galleries, Jiyong Lee, "White Embryo Segmentation" 2013, 7 x 13.5 x 5" Cut, color laminated, carved glass, AVAILABLE

(www.adgorithms.com) - There are so many types of performance advertising. In video advertising, it is like a banner ad. The only difference in video advertising, real moving video clips is exhibited. As such, video advertising is prominently seen on televisions, and advertisers more often than not use the same clips when they advertise online.

performance ad network

Human resources officer choose employee standing out of the crowd. Select team leader concept. Gender discrimination in employees selection.

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

(Further pictures you can see quite easily by clicking on the link at the end of page!)

Vienna 1, The Franciscan Church

The Franciscans go back to St. Francis of Assisi and thus the 13th Century. They were founded as a mendicant orders but soon the arose the question how literally one should take the declaration of poverty. Was it allowed to make financial provision for elderly or sick brothers? Finally it came to the segmentation of the faith community, the more liberal Minoriten (Friars Minor Conventual) made ​​their own order, while the Franciscans followed the old conventions. 1453 came the first Franciscan, John of Capistrano, to Vienna.

He founded the first Franciscan monastery in what is now 6th District. But the monks had to flee when the Turks besieged Vienna in 1529 and the monastery burned down. It took until 1589 until the city of Vienna gave them the at that time vacant monastery together with appendant church. The house, in its place now stands the monastery had already been donated in 1306 by wealthy citizens - namely for "loose women" who wanted give up their trade and convert themselves.

1476 was at the Weichenburg (hence Weihburggasse) inaugurated a church with seven altars, where formerly a "Pfarrheusl (small parsonage)" had stood for the soul welfare of the female residents. At the time of the Reformation, however, moral values in this house went downhill. 1553, the Foundation was dissolved, but it took yet until 1572 before the last resident had died. For eight years, the building was then an educational establishment for girls of poor people.

When the Franciscans now had got the property, they started in 1603 with a reconstruction of the church, which was consecrated in 1611. 1614, the foundation stone was laid for the new monastery.

The statues on the west facade are left Francis of Assisi and Anthony of Padua right. In the middle, on the pediment of the west portal of the Church stands Jerome, protector of the church. He is surrounded by two angle putti.

But let's go inside the church. Maria with the ax is the altarpiece above the high altar. The statue was carved in 1505 from lime wood and has its own story. She comes from the Green Mountain (Grünberg) in Bohemia, which was under the control the Sternberg family. Since the family in the meantime had become Protestant, it wanted to burn the statue. She were thrown into the fire - but the next day she stood unharmed again in the chapel. Now, the executioner was called who should dismember the effigy. However, even that was impossible, because the ax stuck in the shoulder of Mary and it was not possible to get it out. There it is still today. (You have to look closely, but then you see the great ax with slightly curved stem.) But that's not enough. A few years later the Madonna was lost in the gamble by a gegenreformierten (counter-reformed) Sternberg. The new owner, the Polish Baron Turnoffsky gave she in 1607 the Franciscan monastery. Exactly 100 years later, she got her current stand on the high altar.

The stone structure between altar and the statue of the Madonna also contains a crucifix, which dates from the beginning of the 17th Century. The wooden statues left and right represent the Saints Jerome respectively Francis and are typical examples of the so-called Franciscan carving school. It operated 1690-1730 and was run by lay brothers. The overall concept for the high altar dates back to the Jesuit Andrea dal Pozzo.

A special attraction is the organ by Hans Wöckherl that was already built in 1642 and today is the oldest organ in Vienna. It is, however, disappeared from the visible church, because it is behind the high altar and is only shown every Friday between 15.00 und 15.30 clock. In addition, one demans for that six euro entry...

The single-nave church has to both sides side chapels, of them I want to show two.

On the left we see the Magdalene Chapel, which was consecrated already in 1614 for the first time. 1644 and 1722, however, followed ​​Neustiftungen (new foundings). The stucco decoration stems from 1644. The paintings in the vault are much more recent, from 1893. The altarpiece depicts the grieving Mary Magdalene under the Cross. It was created in 1725 by Carlo Innocenzo Carlone. The image above shows Veronica's handkerchief with the face of Christ. It was painted by Wolfram Koeberl and in 1974 installed. The statues beside the altar represent the Virgin Mary and John the Baptist. The two above chapels are provided with food grid, so that one could give Communion here.

An Immaculata chapel (pictured above right) is there since the existence of the church, but this was rebuilt in 1722. Previously, since 1642, there was a Michael altar here. From this period dates still the stucco decor on the ceiling. The altarpiece is by Johann Georg Schmidt, who painted it in 1721. The lateral statues depict the Saint Joachim and the mother of Mary.

Also the Capistrano Chapel, which was founded in 1723, is worth mentioning. The lateral stucco decor shows on the left side (picture) the glorification of St. John Capistrano, who, as I said, was the first Franciscan in Vienna. Right you can see him as a standard-bearer of Christian doctrine in the wars against the Turks. Both stucco images date from the time of the foundation. The altarpiece by Franz Xaver Wagenschön originated in 1761 and shows Capistrano in a scene from 1451, in Brescia when he healed a possessed man.

In the picture we see also the statue of Saint George, as he is killing the (admittedly small) dragon.

On the other side of the chapel is the Holy Florian, while Clara and Theresa stand next to the altar. Behind the altar there is a reliquary in glass from about 1720, in which we see a wax image of the Holy Hilaria. The relic shall be imbedded in the wax. Hilaria is rather unknown, but she was a martyr who was converted by Bishop Narcissus. She died in the year 304 in Augsburg, at the behest of the governor Gaius, because she did not want to renounce the Christian faith. About the nature of death, there are different opinions.

In the church there is a plaque that claims that she was burned at the grave of her daughter, while the Holy Encyclopedia states that she was enclosed in her house and this was then set on fire.

In the chapel opposite, the Chapel of the Good Shepherd, there is also a glass coffin with a relic. This is the skeleton of the Felix Puer wearing the uniform of a Roman Centurion.

As a counterpart to the pulpit, this just opposite, you will find the monument of Johann Nepomuk. We see how he flows on the water of the Vltava river after he was thrown in Prague there. He actually was called "John from Nepomuk" in Czech "ne Pomuk". The wife of Emperor Wenceslas IV is said to have chosen him as confessor. The Emperor wanted to know then what she had confessed, but Johann Nepomuk did not betray the seal of confession and was therefore thrown into the water. The Empress had then an appearance of five stars.

(We see she also in the water of the monument.) These stars indicated were one could find the body. So much for the legend.

The fact is that Johann Nepomuk was tortured by the king and thrown into the Vltava. The activating moment was a dispute over a new monastery between the emperor and the archbishop of Prague, in which John Nepomuk was trampled underfoot ...

The pulpit was built in 1726 and was executed by the Franciscan carving school. At the parapet there are wooden reliefs of Matthew, Mark and Luke. The relief of the fourth evangelist, John, is attached to the pulpit door. At the parapet you further can see statues of Capistrano and Bonaventura, while on the sounding board are sitting Anthony of Padua and Berhardin of Siena. At the top stands the freeze image of Francis of Assisi.

The pews were 1727 - 1729 by brother Johann Gottfried Hartmann built and carved.

www.werbeka.com/wien/wien4/franzisd.htm

Cikuan Bra fishtail wedding, suffused with a soft sheen satin belt with good visual segmentation add layering, simple fishtail skirt lined sketched out the bride graceful posture, nestled in the tissue, akinds of the looming beauty, particularly sultry.

We can finally see the segmentation of the archway supporting stones. Flanking walls were thrown in to show the growth of the model.

20. November 2019, Jugendstilhörsaal der MedUni Wien

“Multiparametic Diagnostics and Theranostics of Tumors”

Fabian Kiessling, Universitätsklinikum Aachen

Abstract:

Significant advances have been achieved in elucidating molecular regulations of cancer and numerous disease-related markers were identified. Additionally, imaging technologies steadily improved and are providing detailed insight into tissues’ morphology, function and molecular regulation. However, there is still a need to identify and quantify the most relevant information and to bring it into a mechanistic context.

In the first part of my talk, I present advanced imaging strategies to characterize tumors by assessing various “hallmarks of cancer” using non-invasive imaging and to assess therapy responses. In this context, I will discuss novel computer applications to improve data processing, lesion detection and segmentation as well as radiomic image analysis. However, taking a study on hepatocellular carcinoma therapy with a multispecific tyrosine kinase inhibitor as an example, I will also show that correlative analyses do not always lead to correct conclusions on biological mechanisms and that the interconnection and impact of the observed changes need to be understood.

The second part of my talk will be dedicated to drug delivery. Here, I will show how imaging can be used to improve the preselection of patients to therapies and discuss the value of nanomedicines and active targeting. Furthermore, I will highlight the potential of ultrasound mediated theranostics to overcome biological barriers and to improve tumor perfusion.

(c) MedUni Wien / Kovic

This is a sketch of possible real time interaction with a video environment using segmentation. This was done with a traditional editing, but shows the idea of doing video processing & interaction in real time using openCV.