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Giving thanks to co-host Reid Hoffman with Ned from Harvard. More photos in comments below.
Such a fun weekend at an eclectic brain spa. I’ll share some of the highlights in my crude screen shots. Overall, it felt like we are in the midst of an interdisciplinary Renaissance, from novel measurement and imaging techniques to machine learning and bold new experiments in animal and humans.
We learned how super-absorbent diaper gel polymers can make a brain expand for easier imaging, and how it can be optically read and modified. At least five speakers referenced an explosion of interest in the rapid-acting drug ketamine (for depression and OCD) and a surprising finding that it operates through the opioid receptors.
We learned how vasopressin might treat autism and how girls of depressed mothers have radically different brain development and telomere length.
"While the male and female brain differ in development, the male and femaleness of the brain is regional." — Manpreet Singh
Notes from Day 1: SATURDAY, SEPTEMBER 8, 2018
New Conceptual Frameworks in Mental Health - Amit Etkin
I had lunch with him a well. He gets much more data from the EEG than the fMRI. We are generally poor at describing our mental state. Our friends generally do a better job on identifying if we are depressed.
10:00 am — Tools for Analyzing and Repairing the Brain - Ed Boyden
MIT’s Ed Boyden has the largest brain lab in the world, with 150 people.
Expansion microscopy is the opposite of normal microscopy. Instead of zooming in on the brain, you make the brain bigger with a polymer expansion similar to the gel found in super-absorbent diapers. youtu.be/jLvynWieWk8
Color coded with a virus payload for seeing different cells, a “brainbow”
www.ted.com/talks/ed_boyden_baby_diapers_inspired_this_ne...
Optogenetics, with light-activated ion channels: youtu.be/evisCB6mwt0
Can trigger brain activity at a targeted deep area with a pair of acoustic waves at close frequencies, like 2.00 and 2.01 Hz.
Digital Phenotyping - Tom Insel
He can deduce your mental state from social networks based on how you type and click (patterns in timing) not the content of what you type (less privacy concerns). Signals from the phone predict how the mood will be for the day. He can even see the effects of ketamine, a rapid-acting anti-depressant.
We can move from subjective, episodic, burdensome, clinic-based measurements to objective, continuous, passive in-situ measurements. 7cups is using it for alcoholic treatment.
11:00 am — The Supercharged Brain, Mental Health and Aging - Ruth O’Hara
The normal aging brain shrinks by 15% (Alzheimer’s another 10%). Depression shrinks the hippocampus, and that impairs memory.
Physical exercise and targeted cognitive training can improve your brain.
Very excited to grow neurons in a dish from skin stem cells. Easier to do with young people than the aged.
Envisioning the Brain Mind Clinical Lab of the Future - Leanne Williams
Imaging brain activity in cognitive dysfunction. Many different mental states we call depression, and they respond to treatments differently.
For example, sub-type 1 is characterized by Default Mode Network. If it becomes too connected, too much internal reflection, ruminations, worry, waking up early in morning, and unable to stop thoughts about terrible things might happen.
New Stanford Center for Precision Mental Health & Wellness.
Novel Platforms for Novel Treatments in Neuroscience - Rob Malenka
25% of the world will develop a serious brain malfunction in their lifetime.
If your brain is not functioning, you are not yourself. With addiction and OCD, you have no control over your behavior.
Anhedonia is a common symptom in depression, Parkinson’s and schizophrenia.
With all of the academic hysteria about ketamine, we still don’t know how it works, and it was discovered accidentally.
“An example”: we can make a mouse happy or unhappy.
Fireside Chat with Reid Hoffman - Reid Hoffman and Michael McCullough
In blitzscaling, you prioritize speed over efficiency in an uncertain world.
He also rekindled his AI interest 5-6 years ago.
2:00 pm — Revolutionizing Medical Imaging and Brain-Computer Communication with Consumer Electronics - Mary Lou Jepsen
If you spend 10-100 hours in an fMRI, we can read your thoughts. 2/3 of humanity lacks access to medical imaging. She wants to reduce the cost 200x and fit it into a ski cap.
Tumor has 5x the blood of normal tissue. And Blood is relatively opaque (versus flesh). Bones are white, and near IR passes through. We can image to 2 microns, the diameter of the smallest neuron. Use laser and sound wave that shifts the wavelength ever so slightly.
TED Talk just came out: www.ted.com/talks/mary_lou_jepsen_how_we_can_use_light_to...
3:10 pm — Shining a Light on the Treatment of Alzheimer’s Disease - Li-Huei Tsai
40 Hz flickering LED light induces gamma oscillations in the brain. After 1 hr of exposure, she saw a 50% reduction in amyloid plaques in a Alzheimer’s rat model.
The microglia (the brain’s immune cells) undergo dramatic transformation in their morphology and become much more efficient at picking up toxins like beta-amyloid.
To Sleep or Not to Sleep: How the Brain Decides to Wake Us Up - Luis de Lecea
Sleep decreases as we age and with Alzheimers (it’s the main reason AD patients get institutionalized).
How does the brain control sleep? The hypothalamus is only 3% of the volume of the brain but controls sleep, appetite and circadian rhythms.
Parabiosis – would the blood of the young mouse rejuvenate the old? The opposite occurred. Molecules in the old brain were toxic in the younger brain.
Quieting the Obsessive Mind: Ketamine and Other Rapid-Acting Therapeutics - Carolyn Rodriguez
In OCD, a thought continuously invades or intrudes in our mind. 2% lifetime prevalence. Half of cases start by age 19.
Only FDA-approved medication: SSRI’s like Prozac take 2-3 months, and fail half the time.
Ketamine is a glutamate-receptor-blocker which increases GABA in the pre-frontal cortex. But if you take naltrexone, which blocks opioid receptors, then ketamine loses its effect. This was a surprising result; there is some connection to the opioids.
Ketamine rapidly and dramatically lowers OCD, with effects lasting days post-treatment.
ADD: Karen Parker and Antonio Hardy on Autism
Why so few diagnostics and therapies in autism? The biology is poorly understood.
With early detection, you can gain 15 IQ points and lower the cost of care by 7%.
She studies monkeys on the anti-social extreme. Behaviors are similar to autism. Vasopressin helps. Perhaps vasopressin signaling is impaired in autism. When given to human childen, social behavior improves.
Accelerating Discovery to Promote Healthy Brain Outcomes Starting from Birth - Ian Gotlib
Adolescence is a period of suicide risk, and it’s getting worse. The CDC recently came to Palo Alto to look at what’s going on in this suicide cluster.
The biggest risk factor are 1) family history 2) being female
There are 200 million depressed mothers with daughters who have not become depressed yet. She studied those daughters. They have a big change from other similar aged girls. Smaller hippocampus. Shorter telomeres already by age 12. When they check in 10 years later, 60% of those girls became depressed.
By age 9-14, it might be too late already. So, they did infant studies and of the pregnant mothers (measuring continuous cortical level from hair samples during pregnancy). And they gathered a lot of passive data. The infant’s brain volume correlates with number of words heard in utero. And they were disturbed to see the strong correlation with income level.
Prenatal stress lowers hippocampal volume and amygdala connectivity.
Manpreet Singh
Brain is the most genetically determined organ in the body.
While the male and female brain differ in development, the male and femaleness of the brain is regional.
Using our new camera for the first time. We were going to buy a tripod. Guess what we found in the garage this week from last Burning Man.
I'll leave u to discover stuff, ask questions and add notes. Feel free to go to town. I'll answer questions and add notes.
No neighbors discovered us - that I know of. Hee hee.
FGR • Flickr Notes'
"So take a picture in front of of your trophy collection, your book case, or even your wardrobe! The more interesting, the better. Everyone should also do their part, and add as many notes as you can. Make it so we can't even see the picture!
And to make it interesting, you'll get extra credit for:
*Not wearing Pants.
*Showing Your O Face.
*Fitting into the Stragecially Placed category.
And, if you can do all 3, plus be super noteworthy, you'll be a golden god! "
Sample List What to Bring to Burning Man
Our 2007 YouTube PlaylistBurning Man
My Flickr video of Burning Man welcome signsdriving in to Burning Man
i know it's slightly silly and cheesy, but we like to leave little notes for the other to stumble upon.
those little reminders are nice.
Notes: Don Limn poses in his Katoomba High School Cadets uniform, identified below
Format: silver gelatin negative, 4" x 5" (10.2 cm x 12.7 cm) Kodak Royal Pan
Date Range: 1960
Location: Katoomba
Licensing: Attribution, share alike, creative commons
Repository: Blue Mountains City Library - library.bmcc.nsw.gov.au
Part of Local Studies Collection: SS 07-01
Provenance: Souvenir Snapshots
Links:
If there is anything unusual about the simultaneous launch of the Samsung Galaxy Note 5 and S6 Edge, it is the fact that this has taken the tech-savvy population by surprise. There is nothing peculiar about two high-end smartphones releasing at the same time but how often do you see a company...
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We cooked a lot of food for five people, but now we all have good stuff to eat for a couple of days. The foods noted are the leftovers.
Constelaciones, auroras, galaxias, eso siento en mi pecho cuando tus manos bordean mi cintura, cuando nuestras bocas están cercanas pero no se tocan, cuando somos uno solo en el universo. eres mio aunque no seas de nadie.
Yes let's meet autumn as our mid-autumn festival is coming! Things do converge mysteriously with or without you knowing or seeing, finding the connections is no big achievement but brings small pleasures to our lives.
I was in Seoul 2 weeks ago meeting Mr. Nam who's company Appree just launched "Leaf-it" and already shipped to Japan's Marcs International for distribution. The leaf post-it comes in 8 different types, each with various sizes and colors of leaves. I hope they are coming to our stores soon.
Two days ago I received a Mackinaw Autumn package from Field Notes, another hint of autumn coming, in colors I'm so very in love with. I regret that I missed their summer collection (Butcher Orange, Butcher Blue, Grass Stain Green). Hmmm.... so Tradio Nature just came to me, Leaf-it and Mackinaw Autumn are both on my desk now, they are all here to set something in motion, the welcoming of our 3,000 years old tradition, mid-autumn festival.
Tasty moon cakes await us, beautiful lanterns hanging all over the places, family gathering dinner and Chiu Chau tea ceremony at home..... such a pleasant anticipation. I particularly like what the shops do on Queen's Road West, about 5-6 stores normally selling incense for worship now hang hundreds of lanterns so beautifully which lighten up the streets. I was there with family on Sunday night, people were there lingering in such warm atmosphere. Tomorrow we will definitely go the park with our lanterns.
PS. My son told me something funny this evening: "God has no time to talk to us, because he has to make up some homework for us, so God is very difficult and we have to thank Him". Where did he get the ideas?
More on Scription blog: moleskine.vox.com/library/post/meet-autumn.html
Die Schweizer 10er-Note ist der offizielle Flyer der «Volksinitiative für ein bedingungsloses Grundeinkommen»
Foto: Pola Rapatt
Stamps:
Music Score
Wavy Music
Just a Note...
Paper:
Recollections Black Cardstock
Mohawk 80# smooth white cardstock
Ink:
Ranger Antique Linen Distress Ink
Memento Tuxedo Black dye ink
Other:
Dots & Dashes Ribbon
sponge
Spellbinders circle dies
Instructions:
1) Sponge Antique Linen ink randomly on a 4" x 5 1/4" white panel and adhere to a 5 1/2" x 4 1/4" top folding black card.
2) Stamp Music Score in black ink on a 3 1/2" x 3 3/4" white panel.
3) Sponge Antique Linen ink randomly on stamped panel to create aged look. Back panel with a slightly larger black panel.
4) Wrap polka dot ribbon around the left side of the music score panel and then adhere to the left side of the card as shown
5) Die Cut a white circle panel and sponge Antique Linen ink randomly on it before backing with a slightly larger black die cut circle and then adhere to card front.
6) Stamp Wavy Music image on a white scrap and cut out around edges. Sponge Antique Linen ink randomly across image and then adhere across circle panel as shown
7) Ink half the sentiment stamp with black ink and stamp on lower right corner and then ink the other half of the stamp and stamp above
Music to my Ears
80% Cotton / 20% Linen
Approx Fabric Swatch: 6" x 3.5"
Background: Linen Natural with white stamps and musical notes
great imported japanese fabrics
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I had totally forgotten to tell you that my super cute sticky notes set is now available exclusively at Anthropologie.
*Photos from anthropologie.com
There is enough for everyone. I laugh when I hear kids say, "I liked that song first and now she likes it.....GOSH!"
monsieur! crossing ze street is so dangerouse!
So it's less than 24 hours until the KOTO sponsored bike ride.
An eighty kilometre bicycle ride through the still green lakes and hills of Vietnam, to raise money for a worthy cause: the education and training of street children of Ha Noi, by an aussie charity here.
I'm all hyped up. Pumped, as Arnie says. I'm ready to kill myself doing this.
And kill myself doing this is extremely likely.Did I mention that I'm not really outdoorsy?That despite my action man exploits underwater, back on dry land, I remain the world's biggest seven stone weakling?Did I mention that I haven't ridden a bicycle in fifteen years?Did I mention that I haven't done any physical exercise at all since rowing with the british dragonboat team in Singapore four weeks ago?I did mention that just those two hours left me crippled for two days, didn't I?Did I point out what eighty kilometres is in imperial measurements? It's FIFTY MILES. When I wrote to everyone in my address book asking for sponsorship, I didn't realise this. To a Brit, every metrical measurement appears tiny. I assumed this would be something simple, like a foot or so. 80 metres. 80 centimetres. Perhaps 80 millimetres. You know, something possible?I ever mention to you that even in the gym in days of yore, the stationary bike machines were the one thing I couldn't cope with? That my thigh muscles are such flaccid dead fish of a human sinew that they usually appeared to split at the seams after just 75 repetitions of pressing down an unweighted wheel to get nowhere?Many of my good sponsors have communicated an earnest hope that I have been in training since I foolishly agreed to murder myself by two wheeled means. This is not so. My training regime has been a peculiar one. It involves food poisoning, a full week laid prone in bed, running to the toilet every hour, and eating one bowl of rice and boiled broccoli a day. I look skinnier, yeah, but fitter? Think 'The Pianist'.Have I mentioned that Ha Noi's road traffic doesn't follow any rules whatsoever? That simply crossing a road intact was a Vietnamese challenge set by one reader, here?The streets are infested with speeding mopeds, ridden to be seen, not to get from A to B, and therefore populated with the type of motorist whose mirrors are angled to check their hair is straight rather than to stay alive.The rules of the road are: the bigger the vehicle, the faster you have to move out of the way. Horns are a deafening everpresent scrum. A horn beeping replaces the indicator lights, replaces the use of brakes, alerts people to the oncoming road accident, and tells everyone that you're rich enough to have a moped. Horns beep day and night in an orchestral cacophony. Horns beeping will not save me from harm.Did I tell you that the reason I never cycled in London was because I'm not roadworthy. I was the only kid in my primary school class who didn't pass the Cycling Proficiency Test.Did I tell you that the last time I cycled anywhere, I had to ask a friend to cycle just in front of me, so I could steal the signals from her without looking behind me? Because if I look over my shoulder, I wobble ten feet to the left, then fall off the bike?That I've never yet managed to stay on the bike on a mild incline?That I have a serious problem navigating Ha Noi's streets, and have only once managed to leave my hotel without getting lost within six paces?That one of the KOTO bike rides central problems is that people with an actual sense of direction get lost year after year?Are you feeling quite how bloody foolish this bike ride will be for me yet?Nevertheless I will do this.
I will do this because KOTO is a really really worthwhile cause. I will do this because I promised my friends if they sponsored me, I would photograph my agony and embarrassment.
I will do this because having read this promise, my sodding bloody over-generous friends committed more than $800USD in just 48 hours, if I kill myself on Saturday.
Every mile I ride, every muscle I tear, every ragged gasp I breathe, every pained tear I shed, every tendon I split will be recorded for their delectation.
And it will kill me.
"if you're not willing to be changed by a place, there's no point in going."
If you're willing to add to the sum raised by my death, and are titillated by the thought that KOTO will sell you pictures of it, please leave your email and your sponsorship promises in the comments below.
Roll call of esteemed sponsors:
Russell Braterman, Germany, Eroica from Frogstar World, NZ, Looby from Gay Nazi Sex Vicar ..., UK, Francesca from End Message, UK, Vikki Tomlinson, UK, Martin from Web Frog, UK, Tess from Bored and Broke, Northern Ireland, Duch, UK, my mum and dad, UK, Margret Smith, Spain, Ruth Gilburt, UK, jatb, UK, Will of Moving Forward, Mexico, Tim Worstall, UK, Karen from Secret Walk, Phillippines, Robin Brzakalik, UK, my sister, UK, Paul from Noxturne, USA, Paula Newark, UK, Fishboy from Effing the Ineffable, Australia, Pete Connolly, UK, Yidaho from kitchensunk, UK, Bloom from Tales from the Chalkface, UK, Madeleine Minson, Sweden, Emma from Etcher: A Print Maker's Diary, UK, my mum's boss at work, UK, Terry of More Coffee, Less Dukkha, UK, Mike of Troubled Diva, UK, Nicole Hammond, UK.
Killers, all of them.
Xiaomi Hongmi Note Smartphone single Sim Android Octa Core OTG 4G Version White
•Cpu Mediatek MTK6592 Octa Core 1.7 Ghz
•Display 5.5 inch - Resolution Full HD
•2 Gb Ram - 8 Gb Rom
•MIUI V5 (Based on Android 4.2 - with Google Play)
•OTG - WiFi - GPS - Bluetooth
•Back Camera 13 Mpx - Front Camera 5 Mpx
•Battery 3100mAh
•4G FDD-LTE 1800/2100 MHZ WCDMA 850/900/1900/2100 GSM 850/900/1900/2100
•Single SIM Slot
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Petit cahier de notes que je traine avec moi lorsque je fais de la photo argentique.
Little notebook that I carry with me when I'm shooting film.