View allAll Photos Tagged data_warehouse
David Stein presenting at SQL Saturday 2011 in Chicago
David Stein is a SQL Server Business Intelligence DBA specializing in designing, developing, and maintaining Data Warehouses using Microsoft BI Tools. He blogs regularly at Made2Mentor.com and frequently presents on the local and regional level. He is also considered the world’s foremost expert in a SQL Database ERP Product that few have ever heard of.
SQL Saturday Chicago
SQLSaturday is a training event for SQL Server professionals and those wanting to learn about SQL Server. This event will was held Mar 26, 2011 at DeVry University Addison Campus1221 North Swift Road, Addison, IL 60101.
SQL Saturday #67
www.sqlsaturday.com/67/eventhome.aspx
View the high resolution photo on my photography website
Knowledge doesn't come easily. It comes through cost, efforts and last of all but not least through a skilled craftsman.
I represent Onlineitguru. Onlineitguru.com is a global online IT training company. We offer virtual online training on all major IT Technologies Like SAP/ Oracle/Data WH/Testing Tools to mention a few. Onlineitguru.com was started by highly experienced industry experts and our parent company has got more than 7 years of experience in IT development, IT consulting and corporate training as well. We engage the trainers, those who are Industry experts and teaching experts. Onlineitguru.com has got renowned experienced trainers in all IT Technologies.
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Onlineitguru.com is a Global Interactive Online Learning Portal started by SAP Experts with an aim to provide a Job Oriented Training on SAP All Modules.
ABOUT OUR FACULTY: We have excellent SAP BPC 10 instructors, who have Industry experience experts in Online Training.
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A) Resume Preparation
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We have a forthcoming online batch on SAP BPC 10
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OTHER DATA WAREHOUSING TOOLS OFFERED:
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* SAP
* IBM Mainframes
* Microsoft Technologies
* Testing Tools
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A previous NATO and UK command centre in the centre of the Rock used since WWII and up to a few years ago, the ComCen (Communications Centre) was the hub of the military establishment based in Gibraltar. Now converted into a data warehouse the current leasholders have taken care to preserve the planning room and General Eisenhower's war room from which he planned and executed the North African Campaign during WWII.
Britain has closed down its military communications centre at Gibraltar, wih such responsibilities having been transferred to Faslane in Scotland.
The last signal from 'CommCen Gibraltar' was on Friday; it said: "I am closing down on all circuits."
For over 130 years, Gibraltar has been a pivotal link in British military communications maintaning a constant watch - "from submarine telegraph, through wireless and radio, to computer-controlled automated digital systems," said a British military spokesman.
Gibraltar has had a permanent physical communications link to the UK since 1870.
"During its heyday, up to 150 tri-service communications personnel were assigned to CommCen Gibraltar," said a statement from the Command British Forces at Gibraltar.
Technological advances, automation and organisational changes throughout the 1980s and 1990s saw a gradual drawdown of personnel. Further automation this year has now led to the final closure of the military communications centre at Gibraltar.
© DM Parody 2010
A previous NATO and UK command centre in the centre of the Rock used since WWII and up to a few years ago, the ComCen (Communications Centre) was the hub of the military establishment based in Gibraltar. Now converted into a data warehouse the current leasholders have taken care to preserve the planning room and General Eisenhower's war room from which he planned and executed the North African Campaign during WWII.
© DM Parody 2010
21cssindia offers Online Training worldwide. Implementing high standards of quality online training. ✔Talend ✔Siteminder ✔Sharepoint ✔Cognos ✔Cloud Computing ✔IBM unica ✔Tibco ✔Informatica ✔SAP ✔Xcelsius ✔PearsonVUE ✔Pega
David Stein presenting at SQL Saturday 2011 in Chicago
David Stein is a SQL Server Business Intelligence DBA specializing in designing, developing, and maintaining Data Warehouses using Microsoft BI Tools. He blogs regularly at Made2Mentor.com and frequently presents on the local and regional level. He is also considered the world’s foremost expert in a SQL Database ERP Product that few have ever heard of.
SQL Saturday Chicago
SQLSaturday is a training event for SQL Server professionals and those wanting to learn about SQL Server. This event will was held Mar 26, 2011 at DeVry University Addison Campus1221 North Swift Road, Addison, IL 60101.
SQL Saturday #67
www.sqlsaturday.com/67/eventhome.aspx
View the high resolution photo on my photography website
IT Spark provides an large Data Warehousing Training Courses and Job Assistance. We are professional Data Warehousing Training Institutes Noida.Get connected with best Data Warehousing Training Center Delhi NCR.
Brian is a seasoned executive with a proven track record in growing technology based organizations and leads the Better Place Hawai‘i project. He has over 20 years experience in senior management, business development, sales, and marketing in the enterprise software, data warehousing, business intelligence, consumer internet, medical software, and biotechnology industries. Brian also serves as a Vice-Chair on the boards of Hawai‘i High Technology Development Corporation (HTDC) and the Natural Energy Laboratory of Hawai‘i Authority (NELHA).
David Stein presenting at SQL Saturday 2011 in Chicago
David Stein is a SQL Server Business Intelligence DBA specializing in designing, developing, and maintaining Data Warehouses using Microsoft BI Tools. He blogs regularly at Made2Mentor.com and frequently presents on the local and regional level. He is also considered the world’s foremost expert in a SQL Database ERP Product that few have ever heard of.
SQL Saturday Chicago
SQLSaturday is a training event for SQL Server professionals and those wanting to learn about SQL Server. This event will was held Mar 26, 2011 at DeVry University Addison Campus1221 North Swift Road, Addison, IL 60101.
SQL Saturday #67
www.sqlsaturday.com/67/eventhome.aspx
View the high resolution photo on my photography website
The data warehouse interview questions are something that is related to all aspirants giving them the opportunity to learn all basic new things and important aspects well before nay interview. The informatica interview questions and answers for experienced will help and accordingly guide the individual through all process in simple and effective ways. The article is also about how such things can be prepared.
Matthew Walls, Vice President of Business Intelligence and Data Warehouse at Domino's Pizza presents: "Strike Out to Quick Strike: Our Evolution of Business Intelligence".
Talking business intelligence and data warehousing with Teradata at the TDWI Big Data Analytics Forum
Lunch being served TDWI World Conference Exhibit Hall, which focuses on business intelligence and data warehousing.
ARSR delivers Data Science Analytics based technology solutions that comprise data management, EIM, business intelligence &data warehousing.
Information Builder boot at the TDWI World Conference Exhibit Hall, which focuses on business intelligence and data warehousing.
Job Opportunity for CPT/OPT Consultants..
Free Online Training & placement program for OPTs
Job Opportunity for CPT/OPT/ Consultants..
Online Training – Placements with our Clients
We are starting new batches in various skill sets in the month AUGUST – Let me know if you are your friends interested.
Training Highlights:
JAVA |PEGA | MS.NET | Sales Force | ORACLE | SAP | UNIX | BA | QA | SQL SERVER | DATA WAREHOUSE & DATA MINING | DATA STAGING | WEB TECHNOLOGIES |
• Free Online Training
• Free Accommodation
• Daily Training (Daily 2 to 3 hours)
• Dummy Project After completion of Training
• Resume Preparation and Mock Interviews
• Excellent Lab Manuals and E-Books, Online Doubts Clarification
• Free H1B Process
• Certified Trainers
About Orange Information Technology Solutions, INC:
Orange Information Technology Solutions is an industry leader business consulting firm with extensive presence over the northern American subcontinent. Our expertise engulf a wide range IT solutions including SAP , Oracle , Peoplesoft, Java , .Net , ETL tools for our trusted clients. Propelled by an elite array of highly talented professionals Orange comprises of state of the art SAP consultants, Oracle consultants, IT developers, HR’s and business Analysts. Our extensive professional methodology enables us to deliver project consignments in a timely fashion and exceed client’s expectations.
For more information you can always visit our website at:
Our client base includes SAP, IBM, Cap Gemini,Accenture,Tech systems, Synopsys,Valero, Tesoro, hp,at&t,Dell,Total & more….
With Regards…
Orange Information Technology Solutions, INC
460 5th Ave N , Suite #– 55343234
Hopkins , MN
Phone: 952-314-2731
Fax : 952-314-2728
Email: contact@stafforange.com
Job Opportunity for CPT/OPT Consultants..
Free Online Training & placement program for OPTs
Job Opportunity for CPT/OPT/ Consultants..
Online Training – Placements with our Clients
We are starting new batches in various skill sets in the month AUGUST – Let me know if you are your friends interested.
Training Highlights:
JAVA |PEGA | MS.NET | Sales Force | ORACLE | SAP | UNIX | BA | QA | SQL SERVER | DATA WAREHOUSE & DATA MINING | DATA STAGING | WEB TECHNOLOGIES |
• Free Online Training
• Free Accommodation
• Daily Training (Daily 2 to 3 hours)
• Dummy Project After completion of Training
• Resume Preparation and Mock Interviews
• Excellent Lab Manuals and E-Books, Online Doubts Clarification
• Free H1B Process
• Certified Trainers
About Orange Information Technology Solutions, INC:
Orange Information Technology Solutions is an industry leader business consulting firm with extensive presence over the northern American subcontinent. Our expertise engulf a wide range IT solutions including SAP , Oracle , Peoplesoft, Java , .Net , ETL tools for our trusted clients. Propelled by an elite array of highly talented professionals Orange comprises of state of the art SAP consultants, Oracle consultants, IT developers, HR’s and business Analysts. Our extensive professional methodology enables us to deliver project consignments in a timely fashion and exceed client’s expectations.
For more information you can always visit our website at:
Our client base includes SAP, IBM, Cap Gemini,Accenture,Tech systems, Synopsys,Valero, Tesoro, hp,at&t,Dell,Total & more….
With Regards…
Orange Information Technology Solutions, INC
460 5th Ave N , Suite #– 55343234
Hopkins , MN
Phone: 952-314-2731
Fax : 952-314-2728
Email: contact@stafforange.com
Sudeep Sakalle a IT Consultant from London that specializes in systems integration,E-commerce, website & custom Software Development in London using open source tools and technologies.
Sudeep Is Director of Infovinity Systems Private Limited and the service company offer include, but are not limited to:
Create web based solutions that you can access anywhere, anytime
Provide bespoke software solutions - tailored to your requirements
Help you discover the potential of your business data
Support and maintain your existing software and legacy systems
Increase your productivity by automating repetitive tasks
Infovinity's Reliable Software Development Team will assist in
Assessing your needs and developing a Internet strategy
Working with you to create, and execute, an adoption strategy Presentations
Coaching, mentoring and training
Business Process Outsourcing
Data Recovery and Backup policy development
Strategies for using Information, Data and media externally
"Much of my initial work is face-to-face, but I am always happy to work remotely, and also to travel when needed. If you would like to talk more about how I can help you make the most use of Internet revolution under recession"
- Sudeep Sakalle, Director,
Infovinity Systems Private Limited, London
UK Based Professional, Expertise Consultation in Customer Relationship Marketing, Supply Chain and Financial Planning Systems, Business Process Engineering, Business Process Outsourcing, Data Warehouse Design, Database Management Architectures and Business Intelligence .
Sudeep Sakalle, IT consultant from London who specialises in systems integration, E-commerce, website & custom software development using open source tools and technologies. Currently live in (as a East-ender) in London area (near Canary Wharf & Beckton Docks).
Sudeep brings background of strong Marketing, Project Management, Internal Administration, and Research & Development to Infovinity clients in London. Sudeep is responsible for the team’s overall vision, business direction, corporate initiatives and goals. He is a proven hands-on leader with a successful track record in business leadership and ownership, both offline in the development of Security Surveillance System for Bank-Note Printing Press in India, and online in creating compelling web solutions. The balance of ‘brick and mortar’ and e-Commerce business experience has resulted in accomplishing goals successfully. In last 5 years Sudeep has been working on various client projects in UK and Europe and also responsible development operations in London.
Sudeep holds a Masters in "Enterprise Information Systems" from the prestigious University of Westminster, London after completing his "Masters in Computer Applications" from the University of Indore, along with certifications from CISCO and Oracle. He is one among a very few who has received letters of appreciation four times in a row from Mr. John Chambers ( CEO, Cisco Systems) for his performance during his preparations for CCNA exams. He can be contacted onsudeep@infovinity.com
"Infovinity is an award winning web design and creative agency, providing professional website design, Ecommerce and CMS systems as well as branding and graphic design solutions for the private and public sector.
Clever technology can be easy to use. Really easy. Infovinity's simple and unique approach to develop CMS content management systems is that "clever technology can be really easy to use. Very easy. So easy that it empowers you and your colleagues, and in the process delivers the rewards that come with an Infovinity web development project."
- Sudeep Sakalle
Contact details : (UK and Europe) | Office : 0044 203 0063 053 | Mobile: 0044 798 8605 209 | TEL: 0044 844 5868 161 | FAX: 0044 844 5867 883
SKYPE (voice support) : sudeep.sakalle | email :sudeep1@infovinity.com | Google support chat : sudeep.sakalle@gmail.com
Sudeep Sakalle
Leading Edge Software & Internet, Business Success Strategies Consultant
Infovinity Systems Private Limited
Website Development Company Based In London
UKWork: +44 844 5868 161
Fax: +44 844 5867 883
sudeep1@infovinity.com
What is SproutLoud MRM+™?
SproutLoud MRM+™ is technology that goes beyond other MRM offerings by adding flexible co-op funds management, robust business intelligence, Auto Enroll™ (turnkey subscription marketing programs), full inventory management and fulfillment, plus online storefronts with ship-to-your-door delivery.
Our online marketing software also provides all of the robust modules and integrated marketing services that you've come to expect from standard MRM, including: direct mail, e-mail, SMS, also known as text messaging, social media marketing, social media automation, media buying for radio, media buying for television, media buying for newspaper placement, data warehousing and lead procurement, database and subscription management services, digital and multimedia asset management, collateral management and fulfillment, print on demand, list management, lead generation, automated marketing programs, Customer Relationship Management (CRM), print services, inventory management, online storefronts, microsites, and personalized URLs (pURLs) - all supported by an integrated business intelligence platform. SproutLoud provides the tools to engage a network of users through automated e-mail broadcasts, a marketing planning and calendar system to organize campaigns, and built in co-op management.
MRM is ideal for companies with local marketing networks: Local Store Marketing, LSM, Salesforce marketing, franchises and franchise marketing, retailers, dealer networks, VAR programs, distributed employees/offices, affiliates, distributed channels, direct marketing channels, sales channel marketing, multi-level marketing, MLM, and more. MRM is also referred to as Marketing Asset Management (MAM), Local Marketing Automation, Automated Marketing Platform, and Enterprise Marketing Management.
Job Opportunity for CPT/OPT Consultants..
Free Online Training & placement program for OPTs
Job Opportunity for CPT/OPT/ Consultants..
Online Training – Placements with our Clients
We are starting new batches in various skill sets in the month AUGUST – Let me know if you are your friends interested.
Training Highlights:
JAVA |PEGA | MS.NET | Sales Force | ORACLE | SAP | UNIX | BA | QA | SQL SERVER | DATA WAREHOUSE & DATA MINING | DATA STAGING | WEB TECHNOLOGIES |
• Free Online Training
• Free Accommodation
• Daily Training (Daily 2 to 3 hours)
• Dummy Project After completion of Training
• Resume Preparation and Mock Interviews
• Excellent Lab Manuals and E-Books, Online Doubts Clarification
• Free H1B Process
• Certified Trainers
About Orange Information Technology Solutions, INC:
Orange Information Technology Solutions is an industry leader business consulting firm with extensive presence over the northern American subcontinent. Our expertise engulf a wide range IT solutions including SAP , Oracle , Peoplesoft, Java , .Net , ETL tools for our trusted clients. Propelled by an elite array of highly talented professionals Orange comprises of state of the art SAP consultants, Oracle consultants, IT developers, HR’s and business Analysts. Our extensive professional methodology enables us to deliver project consignments in a timely fashion and exceed client’s expectations.
For more information you can always visit our website at:
Our client base includes SAP, IBM, Cap Gemini,Accenture,Tech systems, Synopsys,Valero, Tesoro, hp,at&t,Dell,Total & more….
With Regards…
Orange Information Technology Solutions, INC
460 5th Ave N , Suite #– 55343234
Hopkins , MN
Phone: 952-314-2731
Fax : 952-314-2728
Email: contact@stafforange.com
Matthew Walls, Vice President of Business Intelligence and Data Warehouse at Domino's Pizza presents: "Strike Out to Quick Strike: Our Evolution of Business Intelligence".
A previous NATO and UK command centre in the centre of the Rock used since WWII and up to a few years ago, the ComCen (Communications Centre) was the hub of the military establishment based in Gibraltar. Now converted into a data warehouse the current leasholders have taken care to preserve the planning room and General Eisenhower's war room from which he planned and executed the North African Campaign during WWII.
© DM Parody 2010
21cssindia offers Online Training worldwide. Implementing high standards of quality online training. ✔Talend ✔Siteminder ✔Sharepoint ✔Cognos ✔Cloud Computing ✔IBM unica ✔Tibco ✔Informatica ✔SAP ✔Xcelsius ✔PearsonVUE ✔Pega
sap hana certification in bangalore
SAP HANA is a cutting-edge database technology that offers a high-performance, in-memory computing platform for businesses of all sizes. If your company is looking to improve its database performance and take advantage of the latest SAP technology, then SAP HANA certification in Bangalore is the way to go.
SAP HANA certification will provide your company with the skills and knowledge necessary to implement, configure, and use the SAP HANA database. With SAP HANA, your company will be able to take advantage of real-time data processing, predictive analytics, and much more.
SAP HANA certification in Bangalore will give your company the competitive edge it needs to succeed in today's business world. Contact us today to learn more about our SAP HANA certification program.
Infographic -
Allytech is one of the leading sap s4 hana training institutes in bangalore. They offer a comprehensive course that covers all aspects of sap s4 hana, from the basics to the advanced. The course is designed to give students a thorough understanding of the sap s4 hana system, and how to use it effectively in a business setting. Allytech's experienced and certified instructors provide a high quality of instruction, and the institute also has a well-equipped lab where students can get hands-on experience with the sap s4 hana system.
SAP HANA is a powerful in-memory data platform that enables businesses to transform their operations in real time. The sap hana course in bangalore will provide you with the skills and knowledge necessary to implement and use this cutting-edge technology. You will learn about the features and functions of SAP HANA, and how to use it to your advantage. The course will also cover topics such as data modelling, data warehousing, and data security. By the end of the course, you will be able to confidently use SAP HANA to drive your business forward.
SAP Training in BTM SAP FICO / ABAP / Ui5 Fiori / HANA / MM Training in Jayanagar Bangalore
B-1, 1st Floor, Bannerghatta Slip Road KEB Colony, New Gurappana Palya, 1st Stage, BTM Layout 1 Bengaluru, Karnataka 560029
Mobile: 096062 83331
Email: saptrainingbtm@gmail.com
Webste: bangaloresaptraining.com/
Spotfire at the TDWI Big Data Analytics Forum Reception co-located at the TDWI World Conference in Orlando, FL
TDWI World Conference Exhibit Hall focused on business intelligence and data warehousing in Orlando, Florida
Chris Adamson signs copies of his business intelligence and data warehousing book at the TDWI World Conference in Orlando, FL
21cssindia offers Online Training worldwide. Implementing high standards of quality online training. ✔Talend ✔Siteminder ✔Sharepoint ✔Cognos ✔Cloud Computing ✔IBM unica ✔Tibco ✔Informatica ✔SAP ✔Xcelsius ✔PearsonVUE ✔Pega
MicroStrategy at the TDWI World Conference Exhibit Hall, which focuses on business intelligence and data warehousing.
21cssindia offers Online Training worldwide. Implementing high standards of quality online training. ✔Talend ✔Siteminder ✔Sharepoint ✔Cognos ✔Cloud Computing ✔IBM unica ✔Tibco ✔Informatica ✔SAP ✔Xcelsius ✔PearsonVUE ✔Pega
Zoiks. So I've got a dissertation to hand in by April and a meeting with my dissertation supervisor imminent and I haven't even started it yet. Added to that, I have another assignment due in on normalisation which is really hard as I have to use the taught methods rather than how I approach my normal job (i.e. it's taught stuff rather than common sense). Then I have to build a database to prove it and to hand in a 3000 word assignment about the role of a DBA, rationalising relational databases and other bumf. On top of that I work full-time and we're currently going through an upgrade, and whilst I've done a quick system test on the main database, I'm waiting to get my hands on the data warehouse to give it a good bashing. When I get that, I'll also have UAT to get started, and no doubt the test warehouse will follow very quickly. It's going to be manic and I'm already exhausted (seriously I'm napping every day which is ridiculous!) I genuinely think I'm in denial, in fact I have no idea how the heck I'm going to get everything done. I should have stuck to the plan and by now the assignment would be almost finished and the dissertation would have been written in its first draft.
However, today my new ps vita arrived, I might have already been having a play..... I might be having a play later. I am procrastinating.
Job Opportunity for CPT/OPT Consultants..
Free Online Training & placement program for OPTs
Job Opportunity for CPT/OPT/ Consultants..
Online Training – Placements with our Clients
We are starting new batches in various skill sets in the month AUGUST – Let me know if you are your friends interested.
Training Highlights:
JAVA |PEGA | MS.NET | Sales Force | ORACLE | SAP | UNIX | BA | QA | SQL SERVER | DATA WAREHOUSE & DATA MINING | DATA STAGING | WEB TECHNOLOGIES |
• Free Online Training
• Free Accommodation
• Daily Training (Daily 2 to 3 hours)
• Dummy Project After completion of Training
• Resume Preparation and Mock Interviews
• Excellent Lab Manuals and E-Books, Online Doubts Clarification
• Free H1B Process
• Certified Trainers
About Orange Information Technology Solutions, INC:
Orange Information Technology Solutions is an industry leader business consulting firm with extensive presence over the northern American subcontinent. Our expertise engulf a wide range IT solutions including SAP , Oracle , Peoplesoft, Java , .Net , ETL tools for our trusted clients. Propelled by an elite array of highly talented professionals Orange comprises of state of the art SAP consultants, Oracle consultants, IT developers, HR’s and business Analysts. Our extensive professional methodology enables us to deliver project consignments in a timely fashion and exceed client’s expectations.
For more information you can always visit our website at:
Our client base includes SAP, IBM, Cap Gemini,Accenture,Tech systems, Synopsys,Valero, Tesoro, hp,at&t,Dell,Total & more….
With Regards…
Orange Information Technology Solutions, INC
460 5th Ave N , Suite #– 55343234
Hopkins , MN
Phone: 952-314-2731
Fax : 952-314-2728
Email: contact@stafforange.com
21cssindia offers Online Training worldwide. Implementing high standards of quality online training. ✔Talend ✔Siteminder ✔Sharepoint ✔Cognos ✔Cloud Computing ✔IBM unica ✔Tibco ✔Informatica ✔SAP ✔Xcelsius ✔PearsonVUE ✔Pega
Brian is a seasoned executive with a proven track record in growing technology based organizations and leads the Better Place Hawai‘i project. He has over 20 years experience in senior management, business development, sales, and marketing in the enterprise software, data warehousing, business intelligence, consumer internet, medical software, and biotechnology industries. Brian also serves as a Vice-Chair on the boards of Hawai‘i High Technology Development Corporation (HTDC) and the Natural Energy Laboratory of Hawai‘i Authority (NELHA).
www.nature.com/articles/s41598-022-24053-4
Association between vitamin D supplementation and COVID-19 infection and mortality
www.news-medical.net/news/20221115/Vitamin-D-can-reduce-s...
Vitamin D can reduce severity and spread of COVID-19
In a recent study published in the Scientific Reports journal, researchers in the United States assessed the relationship between supplementation with vitamin D and coronavirus disease 2019 (COVID-19) and related mortality.
Vitamin D deficiency has long been linked to impaired immunological function, which can result in viral infection. In addition, multiple studies have demonstrated that vitamin D deficiency is related to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, it is unclear whether Vitamin D therapy can lessen the likelihood of COVID-19 infection.
About the study
In the present study, researchers performed a large-scale pharmacoepidemiologic investigation to determine the relationship between vitamin D2 and D3 supplementation and the risk of COVID-19 infection-related mortality within 30 days.
The team conducted a retrospective cohort analysis to assess the relationship between vitamin D2 and D3 supplementation and SARS-CoV-2 infection and death. The association was determined using a cohort of veterans affairs (VA) patients who were treated with the supplementation with doxercalciferol (vitamin D2), ergocalciferol (vitamin D2), calcifediol (vitamin D3), and oral cholecalciferol (vitamin D3) between the pre-pandemic period from 1 January 2019 to 31 December 2020, and during the pandemic from 1 March 2020 to 31 December 2020. Prior to calculation, the team matched treated with control patients based on their likelihood of consuming vitamin D2 and D3 supplements separately. In addition, a subgroup analyses for D3 was performed to identify treatment heterogeneity according to race, vitamin D level, and mean daily and cumulative supplementing dosage.
Supplementation with vitamin D2 or D3 was the primary exposure prior to and after the pandemic started on 1 March 2020. The reference group consisted of patients who did not receive vitamin D2 or D3 supplementation. l vitamin D2 and D3 products and dosages were incorporated in the Corporate Data Warehouse (CDW) electronic health records, such as multivitamins and combination medications containing vitamin D3. To examine variance in the relationship between supplementation therapy and COVID-19 infection, a categorical variable representing distinct 25-dihydroxycholecalciferol thresholds was constructed.
The primary outcome of the study involved laboratory-confirmed SARS-CoV-2 infection as measured by any Medicare claim or VA medical record having the International Classification of Diseases 10th Revision (ICD-10) code U07.1. COVID-19-associated mortality was also analyzed as a secondary endpoint. The team defined COVID-19-associated mortality as any death occurring within 30 days of infection.
Results
When potential confounding variables were matched, the groups receiving vitamin D3 supplementation and control participants were comparable. A more significant proportion of Black patients were supplemented with vitamin D2 compared to vitamin D3. In general, vitamin D3 recipients experienced more comorbid illnesses than D2 recipients. The vitamin D3 cohort displayed COVID-19 infection rates of 2.66% and 3.30% for the treated and the controls, respectively. Furthermore, the infection rates followed by mortality within 30 days were 0.23% and 0.35% for the treated and the control participants, respectively. The rates of COVID-19 infection that led to mortality in the vitamin D2 group were 0.20% and 0.26% for the treated and the controls within 30 days, respectively.
Compared to untreated controls, vitamin D2 and D3 supplementation during the pandemic reduced the probability of COVID-19 infection by 20% and 28%. Supplementation of vitamin D3 was related to a 33% decreased incidence of COVID-19 infection resulting in 30-day death. However, vitamin D2 results were not statistically significant. Compared to controls, a higher reduction in COVID-19 infection rates was observed among Black patients than White individuals. It was determined that vitamin D serum concentrations inversely correlated with the decline in COVID-19 infection risk.
The overall treatment elicited by vitamin D serum level interaction was considerable, with a 12% rise in the hazard ratio for each category of serum level. A 25% reduction in COVID-19 risk throughout the spectrum of cumulative dosages and a 27% reduction across average daily dosages were also noted. The cumulative dose-response relationship was inversely related to vitamin D blood concentration.
Overall, the study findings showed that vitamin D2 and vitamin D3 supplementation significantly reduced the risk of COVID-19 infection and death within 30 days. Therefore, the researchers believe vitamin D3 supplementation could be a valuable strategy for limiting the spread of COVID-19 infection and related death and racial differences in COVID-19 outcomes.
Journal reference:
Gibbons, J.B., Norton, E.C., McCullough, J.S. et al. Association between vitamin D supplementation and COVID-19 infection and mortality, Sci Rep 12, 19397 (2022), DOI: doi.org/10.1038/s41598-022-24053-4, www.nature.com/articles/s41598-022-24053-4
www.news-medical.net/news/20221108/Does-vitamin-D-reduce-...
Does vitamin D reduce COVID-19 severity?
A recent review posted to the Research Square* preprint server examined published studies for a consistent association between vitamin D levels and coronavirus disease 2019 (COVID-19) severity.
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the body through the respiratory system, where the SARS-CoV-2 spike protein binds to the angiotensin-converting enzyme-2 (ACE-2) receptors on the bronchial and nasal epithelia.
The entry and rapid replication of the virus disrupt the epithelial-endothelial barrier, causing inflammatory response dysregulation and triggering a cytokine storm. The increased immune response during the cytokine storm can damage tissues and organs and has been linked to long-term fatigue and systemic complications experienced after recovery.
Cytokine storm is an imbalance in the levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interferon-gamma (INF-γ), and interleukins 6 (IL-6) and 1 beta (IL-1β), and anti-inflammatory factors such IL-10. Vitamin D regulates the balance between pro- and anti-inflammatory cytokines, with studies showing significant protective effects of vitamin D supplementation against acute respiratory infections. The active form of vitamin D, calcitriol, is also known to activate antiviral peptides. Understanding the association between vitamin D levels and COVID-19 severity could provide methods to protect individuals against severe outcomes proactively.
About the study
In the present study, the researchers conducted a systematic review of studies that examined the progression of COVID-19 severity based on the vitamin D levels of patients. The review included case-controlled, cross-sectional, observational, clinical, retrospective, and prospective cohort studies that compared median serum vitamin D levels to COVID-19 positivity rates, hospitalizations, COVID-19 severity, and survivors and survivors non-survivors.
The study analyzed the means and standard deviations of vitamin D levels in COVID-19 positive and negative individuals using a meta-analysis effect size calculator. Additionally, the P-value and 95% confidence intervals were also calculated. The researchers also used the t-test to determine differences in vitamin D levels between severe and moderate COVID-19 cases and between COVID-19 survivors and those who succumbed to the disease. Furthermore, they explored studies that examined vitamin D levels concerning hospitalization duration.
Results
The results were near significant when median serum vitamin D levels in COVID-19-positive individuals were compared to those in COVID-19-negative individuals. However, when vitamin D levels were compared with the progression of COVID-19 severity, the results were not statistically significant. The serum vitamin D levels were also not significantly different when compared between COVID-19 survivors and mortalities.
The average median serum vitamin D values for COVID-19-positive patients was 27.08 nmol/L, compared to the 48.67 nmol/L among COVID-19-negative individuals. With a p-value of 0.059, this difference was considered near significant.
The review examined a study that evaluated the impact of vitamin D on inflammatory cytokine levels and found significantly higher levels of pro-inflammatory cytokine IL-6 in individuals with vitamin D deficiency. Patients whose vitamin D levels were higher than 75 nmol/L showed lower inflammatory markers such as C-reactive protein. However, studies showed no significant direct association between C-reactive protein and vitamin D levels. The study also reported lower COVID-19 survival probability among patients with vitamin D levels below 30 nmol/L.
A study comparing vitamin D levels between inpatients who exhibited severe symptoms of COVID-19 and outpatients with milder disease symptoms found that patients with severe symptoms had significantly lower median vitamin D levels (less than 12 ng/mL). Although the difference was not statistically significant, the review found that individuals with higher vitamin D levels had fewer median hospitalization days. However, three contrasting studies also found that patients with higher vitamin D levels stayed hospitalized for longer.
Furthermore, no statistically significant difference was found in the vitamin D levels of individuals with moderate and severe COVID-19 symptoms. The t-test results also reported no significant difference in the vitamin D levels of COVID-19 survivals and mortalities.
Conclusions
To summarize, the review examined various studies that compared median serum vitamin D levels to factors such as COVID-19-positive cases, the severity of the infection, disease survivors, deaths, levels of inflammatory cytokines and markers such as C-reactive protein, and the number of days spent in the hospital.
Overall, the results reported no significant associations between vitamin D levels and COVID-19 severity, mortality, or hospitalization duration. Vitamin D deficiency seemed to be associated with the likelihood of being COVID-19 positive, but the nearly significant association decreased when examined at a larger scale.