STERILITY photos on Flickr

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"It is interesting to contemplate a tangled bank, clothed with many plants of many kinds, with birds singing on the bushes, with various insects flitting about, and with worms crawling through the damp earth, and to reflect that these elaborately constructed forms, so different from each other, and dependent on each other in so complex a manner, have all been produced by laws acting around us." -- On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life (Charles Darwin, 1859).

What Darwin knowingly called 'interesting' came as an explosive revelation to modern thinkers. Hitherto suffocated by the strictures of a desperate and censorious Church, our understanding of the world around us was propelled forward by leaps and bounds through the courage of a man willing to depend upon the strength of his own logic and empiricism in order to bring to light a theory so contrary to popular thought that it could destroy him.His 'tangled bank', regarded as a significant contributor to his inspired thinking, remains in wonderful condition near his former home in the village of Downe, in Kent.

Downe Bank, also known famously as Darwin's 'orchis bank' and so named because of the eleven species of orchid found there, while inevitably missing a species or two since Darwin's time, is an incredible and species rich place to explore.

To think that it lies so near to the comparative biological sterility of central London (twenty minutes by train from Waterloo East) is almost a work of satire.

Seen growing on the bank itself last weekend, Ophrys insectifera (Orchidaceae), the fly orchid, is one of the species that Darwin would have been familiar with. Actually pollinated by a wasp, this orchid, as with most related bee orchids, is dependent on insect mimicry for reproduction -- truly, then, a very sexy flower.

This image is taken from United States Naval Medical Bulletin Vol. 14, Nos. 1-4, 1920 by Medical Heritage Library, Inc.

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Go to the Book with image in the Internet Archive

Title: United States Naval Medical Bulletin Vol. 14, Nos. 1-4, 1920

Creator: U.S. Navy. Bureau of Medicine and Surgery

Publisher:

Sponsor:

Contributor:

Date: 1920

Language: eng

Table of Contents

Number 1

PREFACE V

NOTICE TO SERVICE CONTRIBUTORS VI

SPECIAL ARTICLES:

ANTHROPOMETRIC STUDY AT ANNAPOLIS.

By Lieutenant L. B. Solhaug, Medical Corps, U. S. N 1

Medical and Hygienic Aspects of Submarine Service.

By Lieutenant Commander E. W. Brown, Medical Corps, U. S. N 8

Report on Facial and Jaw Injuries.

By Lieutenant Commander L. W. Johnson, Medical Corps, U. S. N 17

Military Orthopedic Hospitals in the British Isles.

By Lieutenant R. Hammond. Medical Corps, U. S. N. R. F. 65

HISTORICAL :

Medicine in Rome 103

EDITORIAL :

The New Year — Standards of Duty 127

IN MEMORIAM :

Edward Grahame Parker.

By Captain C. E. Riggs, Medical Corps, U. S. N 135

SUGGESTED DEVICES:

Changes in Scuttle Butts Aboard Ship.

By Lieutenant Commander J. A. B. Sinclair, Medical Corps,

U. S. N. R. F 137

An Emergency Evacuation Device 145

CLINICAL NOTES :

Bronchopulmonary Spirochetosis in an American.

By Lieutenant G. W. Lewis, Medical Corps, U. S. N 149

Encephalitis Lethargica.

By Lieutenant A. F. Kuhlman, Medical Corps, U. S. N 151

Defense of the Open-Air Treatment of Pneumonia.

By Lieutenant D. Ferguson, jr., Medical Corps, U. S. N 153

NOTES AND COMMENTS :

Carbon tetrachloride poisoning. —Civil service positions. — Serum treatment

in yellow fever. —" Deer-fly disease." — Request for specimens.—

Medical personnel of the French Navy.—Centenary celebrations. —Situs inversus.

—Italian view of prohibition. — Effects of prohibition In Chicago. — Treatment

of sterility. — Pilocarpine in influenza. —A death from anesthesia.- — Free

hospital service in Oklahoma City. —Birth rate of Manila. —Expansion of the

Faculty of Medicine, Paris. —Statistics on blindness. —French eight-hour law. —

Corporation philanthropy 155

REPORTS :

The Receiving Ship Barracks, New York.

By Commander W. G. Farwell and Lieutenant R. M. Krepps, Medical Corps,

U. S. N 163

Grounding of the U. S. S. Northern Pacific.

By Lieutenant J. C. Ruddock, Medical Corps, U. S. N 185

Impressions of a Reservist.

By Commander L. R. G. Crandon, Medical Corps, U. S. N. R. F 188

Number 2

PREFACE v

NOTICE TO SERVICE CONTRIBUTORS vi

SPECIAL ARTICLES:

Types of Neurological and Psychiatric Cases.

By Lieutenant Commander E. C Taylor, Medical Corps, U. S. N. R. F 191

Yellow Fever.

By Lieutenant Commander T. Wilson, Medical Corps, U. S. N 200

Asepsis of Abdominal Incisions.

By Lieutenant Commander F. H. Bowman, Medical Corps, U. S. N 208

Calcium Chloride Intravenously for Hemoptysis.

By Lieutenant Commander W. H. Fickel, Medical Corps, U. S. N 210

Hospital Records 213

HISTORICAL:

The Arabians and the First Revival of Learning 225

SUGGESTED DEVICES:

Hospital Garbage Disposal.

By Captain A. Farenholt, Medical Corps, U. S. N 237

The Flat-Foot Ladder 240

CLINICAL NOTES:

Chondrodysplasia with Exostoses.

By Lieutenant R. W. Hutchinson, Medical Corps, U. S. N 243

A Case of Vascular Syphilis.

By Lieutenant A. E. Kuhlmann, Medical Corps, U. S. N., and Lieutenant

Commander C. C. Ammerman, Medical Corps, U.S.N.R. F 245

Two Cases of Encephalitis Lethargica.

By Lieutenant Commander R. I. Longabaugh, Medical Corps, U. S. N 249

A Case of Foreign Body in the Head.

By Lieutenant Commander L. M. Schimdt, Medical Corps, U. S. N. 254

The Late Treatment of War Osteomyelitis.

By Lieutenant E. I. Salisbury, Medical Corps, U. S. N. R. F 255

Two Cases of Gas Gangrene.

By Lieutenant Commander L. M. Schmidt, Medical Corps. U. S. N 257

Gastric Ulcer with Perforation.

By Lieutenant G. G. Holladay, Medical Corps, U. S. N. R. F 259

Internal Ophthalmoplegia.

By Lieutenant Commander E. E. Woodland, Medical Corps, U.S.N 260

Open Treatment of a Fractured Metacarpal Bone.

By Lieutenant R. W. Auerbach, Medical Corps, U. S. N 263

Supernumerary Phalanx.

By Lieutenant R. S. Reeves, Medical Corps, U. S. N. R. F 265

A Cask of Ruptured Kidney.

By Commander K. It. Richardson, Medical Corps, U. S. N

Mustard Gas and the Cardiovascular System.

Ry Lieutenant Commander W. H. Michael, Medical Corps, U. S. N

A Case of Ulcer of the Sigmoid Flexure.

By Lieutenant H. R. Coleman, Medical Corps, U. S. N

A Case of Malposition.

By Lieutenant A. C. Toll inner, Dental Corps, U. S. N

PROGRESS IN MEDICAL SCIENCES :

General Medicine — Blood pressure and posture —Intramuscular Injections

of quinine in malaria — Vincent's disease Surgery — Appendicitis amongst

sailors— Transplanting of bone— Rectal ether anesthesia

Hygiene and Sanitation — Destruction of lice by steam

Eye, Ear. Nose, and Throat — Ocular phenomena in the psychoneuroses of

warfare —Ocular complications due to typhoid inoculations

NOTES AND COMMENTS:

Syphilis and the war—Bone surgery —National Research Council— Laboratories

in Poland— National Anaesthesia Research Society — Vanderbilt Medical School —

Municipal education in Detroit — Female medical matriculates— Degrees conferred

by Royal College of Surgeons of Edinburgh — Speech defects — Typhoid fever in

New York — Venereal diseases in California- — Omissions in the Annual Report of

the Surgeon General, 1919

REPORTS :

U. S. Navy Ambulance Boat No. 1.

By Chief Pharmacist's Mate D. V. De Witt, U. S. N

Physical Development in the Navy.

By Lieutenant B. G. Baker, Medical Corps, U. S. N

Venereal Prophylaxis at Great Lakes, III.

By Lieutenants D. It. Blender and L. A. Burrows, Medical Corps, U. S.

N. R. F

Report of 505 Tonsillectomies.

By Lieutenant W. P. Vail, Medical Corps, U. S. N. R. F

BOOK NOTICES

Number 3

PREFACE v

NOTICE TO SERVICE CONTRIBUTORS vi

SPECIAL ARTICLES :

History of the U. S. Naval Hospital, Chelsea, Mass.

By Captain N. J. Blackwood, Medical Corps, U. S. N 311

INSTRUCTION FOR THE HOSPITAL CORPS.

By Lieutenant Commander W. M. Kerr, Medical Corps, U. S. N. 338

Study of Two Cases of Diabetes Mellitus.

By Lieutenant L. F. Craver, Medical Corps, TJ. S. N 345

Flat Foot in the Navy.

By Lieutenant C. F. Painter, Medical Corps, U. S. N. R. F 359

Static Defects of the Lower Extremities.

By Lieutenant A. A. Marsteller, Medical Corps, U. S. N 365

Treatment of Malaria.

By Lieutenant Commander W. H. Michael, Medical Corps, U. S. N 367

Navy Recruiting.

By Lieutenant W. H. Cechla, Medical Corps, U. S. N 371

HISTORICAL:

American Founders of Gynecology 373

EDITORIAL :

"Bring Forth Your Dead "—Is Educational Prophylaxis Effective

381

William Martin —John Wolton Ross —Oliver Dwight Norton, Jr 389

CLINICAL NOTES:

Interdental Ligation for Jaw Fractures.

By Lieutenant W. F. Murdy, Dental Corps, U. S. N 391

A Temporary Stopping.

By Lieutenant Commander H. E. Harvey, Dental Corps, U. S. N 394

ASCARIASIS AND APPENDICITIS.

By Lieutenant Commander E. G. Hakansson, Medical Corps, U. S. N 394

Malarial Crescents.

By Lieutenant Commander W. H. Michael, Medical Corps, U. S. N_ 395

Poisoning by Jelly Fish.

By Commander A. H. Allen, Medical Corps, U. S. N 396

Traumatic Rupture of Kidney.

By Lieutenant Commander F. H. Bowman, Medical Corps, U. S. N 397

A Case of Erythema Multiforme.

By Lieutenant M. F. Czubak, Medical Corps, U. S. N 399

PROGRESS IN MEDICAL SCIENCES:

General Medicine. — Static back trouble—Benzyl benzoate —Relation of

anaphylaxis to asthma and eczema —High enema —Treatment of typhus —Thilerium

hominis 401

Mental and Nervous Diseases. —Insanity as a defense in crime —The nervousness

of the Jew— The Babinski reflex —Problems of delinquency —Encephalomyelitis in

Australia 408

Surgery. — Radium — Surgery of peripheral nerves — Referred symptoms in

diseases of gall-bladder and appendix—Intracranial pressure —Protection of the

skin in surgical operations—Anesthesia

from drugs administered by the mouth —A new skin-suture material —

Roentgen-ray problems , 414

Hygiene and Sanitation. — Birth control—Typhoid fever in vaccinated

troops —Detection of typhoid carriers —Streptococci in market milk

—Tuberculosis in San Francisco —An experiment in sanitary education —Oral

hygiene —Differential diagnosis between trachoma and follicular conjunctivitis

—Left - handedness —The Negritos of the Philippine Islands —Tropical Australia

425

NOTES AND COMMENTS :

American Society for the Control of Cancer — Pay of Italian medical officers

— The passing of the book worm— The neurotic girl —Control of druggists in

Michigan — English statistics on alcoholism —Prevention of simple goiter— Value

of quarantine against influenza in Australia —W. P. C. Barton, first chief of

the Bureau of Medicine and Surgery—Information on blood-pressure estimation

—Automobile accidents —Egyptian Medical School — Educational movement In U. S.

Army 443

REPORTS :

Health Conditions in Santo Domingo.

By Lieutenant Commander G. F. Cottle, Medical Corps, U. S. N 453

History of U. S. S. Pocahontas During the War,

By Lieutenant Commander M. Boland, Medical Corps, U. S. N 460

With the American Peace Commission.

By Commander A. D. McLean, Medical Corps, U. S. N 500

Testing Water for Storage Batteries.

502

Report from Naval Medical School Laboratory 505

BOOK NOTICES 505

Number 4

PREFACE V

NOTICE TO SERVICE CONTRIBUTORS VI

SURGICAL ACTIVITIES AT THE NAVAL

HOSPITAL, NEW YORK.

Interesting bone cases 512

Fractubes of the anterior tuberosity of the tibia and Osgood-Schlatter's

disease 516

Carrel-Dakin technique for empyema 527

Physical therapy 535

Occupational therapy 536

War wounds of the joints.

By Dr. L. Delrez, Faculty of Medicine Liege 537

A case or joint treatment by Willems's method 545

Chronic intestinal stasis 545

Carrel-Dakin technique in treatment of carbuncle 549

A case of sarcoma of the foot 550

A case of Jacksonian epilepsy with spastic contracture 551

A Case Of Osteoma Of The Humerus 552

A Case Of Bone Infection Resembling Sarcoma 552

Wound closures after Carrel-Dakin treatment 553

Ether in peritonitis 557

HISTORICAL:

The founders ok naval hygiene. Lind, Trotter, and Blane 563

EDITORIAL:

Hospital standards —As seen from within 629

SUGGESTED DEVICES :

Vision test apparatus.

By Lieutenant Commander H. W. Glltner, Medical Corps, U. S.N. R. F 637

Treatment of cement floors.

By Captain A. Farenholt, Medical Corps, U. S. N 638

CLINICAL NOTES:

Ophthalmitis in secondary syphilis.

By Lieutenant Commander W. H. Whitmore, Medical Corps, U. S. N 639

TWO CASES OF OPTIC ATROPHY.

By Lieutenant Commander C. B. Camerer, and Lieutenant G. L. McClintock,

Medical Corps, U. S. N 641

Arsphenamine in malaria.

By Lieutenant Commander W. H. Michael, Medical Corps, U. S. N 643

Ureteral calculus.

By Commander W. J. Zalesky and Lieutenant Commander P. F. Prioleau,

Medical Corps, U. S. N 644

PROGRESS IN MEDICAL SCIENCES :

General medicine. — Treatment of respiratory catarrhs.—Tests of thyroid

hypersensitiveness. —A diet sheet for nephritics.— Delayed arsenical poisoning

647

Surgery. —Open treatment of fractures. — Treatment of crushed extremities.

—Nerve injuries of the war 653

Hygiene and sanitation. —Disinfection of tubercular sputum. — Syphilis

in railroad employees 659

Tropical diseases. —Ulcerating granuloma 663

Eye, ear, .nose, and throat. — Frontal sinus drainage. —Anesthetics in throat

surgery. —Correction of nasal deformities

NOTES AND COMMENTS :

American Library Association.— Mental defects in the United States. —

"Tea-taster's " cough. — Scientific basis of carelessness. — "The

case against the prophylactic packet." —Treatment of leprosy. — Medical

training in London. —A new Army and Navy Club. — The Navy Mutual Aid

Association. — Medical school of the University of Virginia. —A new medical

quarterly. —Solar therapy. — Novarsenobenzol subcutaneously. —Economic loss

from rats. —The flight of mosquitoes. —A medical centenarian. — A French hospital

ship. — Potassium-mercuric-iodide.— Dermatitis in industrial work. —

Radium.— A twelfth century epitaph 663

REPORTS :

Arsenical preparations used intravenously.

By Captain E. S. Bogert, Medical Corps, U. S. N 679

Venereal disease in the Dominican Republic.

By Lieutenant J. W. Vann and Lieutenant B. Groesbeck, Medical Corps, U.

S. N 681

American legation guard, Managua, Nicaragua.

By Lieutenant Commander F. F. Murdock, Medical Corps, U. S. N_ 684

Sanitary conditions in Vladivostok.

By Lieutenant A S. Judy, Medical Corps, U. S. N 689

Hospital records.

Commander H. W. Smith, Medical Corps, U. S. N 698

HOSPITAL RECORDS.

By Commander E. U. Reed, Medical Corps, U. S. N 706

A DEATH FROM ETHER DUE TO STATUS LYMPHATICUS.

By Captain A. W. Dunbar, Medical Corps, U. S. N 714

Medical prophylaxis against venereal diseases.

By Lieutenant P. W. Dreifus, Medical Corps, U. S. N 715

BOOK NOTICES 718

INDEX 721

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Note: The colors, contrast and appearance of these illustrations are unlikely to be true to life. They are derived from scanned images that have been enhanced for machine interpretation and have been altered from their originals.

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St Botolph, Trunch, Norfolk by Jelltex

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So, here it is, the reason I drove across Norfolk: Trunch in all it's glory And it is glorious.

It has so many fascinating details, each one alone would be reason enough to visit, but together, in a fine village, next to the village pub, and with that font canopy, one of only four such in all of England, and one of two in the county.

-------------------------------------------

The oldest building in Trunch is St. Botolph's Church. It is mainly 14th. and 15th. Century but there are some fragments of stone in the walls which are believed to have been reused from an earlier Saxon church, which was recorded in the Domesday Book. There is much of interest in the church including a Rood Screen, a hammer beam roof and a rare Font Canopy.

trunchhistory.weebly.com/buildings.html

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The large village of Trunch is located about 5 miles from the north Norfolk coast. In the centre of the village, surrounded by a lovely collection of cottages and the more modern Crossroads Inn, is St Botolph's church. Much of what you see of the church is early 15th century, built upon earlier foundations.

Upon entering the church the first feature you will see is the font, which dates to the mid 14th century. Though the font is attractive, it is the carved and painted font canopy that really makes a visit to Trunch worthwhile.

This is a quite remarkable piece of woodwork, one of only four such canopies surviving in the entire country (the others are at St Peter Mancroft in Norwich, Durham Cathedral, and Luton). The canopy is supported on six beautifully carved legs. The carving detail is exquisite; with fanciful animal figures and foliage and a bit of political commentary, in the shape of a pig wearing a bishop's mitre.

In addition to the font canopy, Trunch features a superb 15th century hammer beam roof, a feature of many churches in Norfolk and Suffolk. Here the carvings of angels are beautifully performed. It is worth bringing along a pair of binoculars or a telescope in order to see the carvings properly.

Much easier to see are the medieval misericords (mercy seats) in the chancel. Each carving is unique; some represent angels, and others are more grotesque in nature. In addition there are some beautifully carved pew ends and a painted medieval rood screen that rivals many more famous churches in detail and colour.

There are 12 niches in the screen, each painted with a depiction of a single figure - 11 disciples plus St Paul. Much of the costume detail is well preserved, but the faces of the figures were destroyed during the upheavals of the Protestant Reformation in the 16th century.

www.britainexpress.com/counties/norfolk/churches/Trunch.htm

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William Earl Warren had the lordship of this town, (fn. 1) of which 3 freemen were deprived; one of them belonged to Herold, late King of England, another to Ralph Stalre, and the 3d to Ketel, who held 90 acres of land, and 14 borderers belonged to it, with 5 carucates among them; there was a church endowed with 10 acres, &c. 3 acres of meadow always valued at 30s. and there were also 5 freemen of Edric in King Edward's time, who had 34 acres of land, with 2 carucates, 2 acres and an half of meadow, always valued at 7s. 4d. (fn. 2)

This town also belonged to the Earl Warren's capital manor of Gimmingham, and paid suit and service to it. In the 34th of Henry III. Maud de Norwich granted by fine, to Richer, son of Nicholas, a messuage, 48 acres of land, a mill, and the sixth part of another in this town, Swathefeld and Bradfeld. In the 15th of Edward I. the Earl Warren claimed a weekly mercate, on Saturday, in this manor; and on the death of John Earl Warren, in the 21st of Edward III. the mercate was valued at 10s. per ann. the manor came after to the Earl of Lancaster, (as is before observed,) and so to John of Gaunt Duke of Lancaster, and King Henry IV. and is still in the Crown, as part of the dutchy of Lancaster.

The tenths were 4l. 10s. deducted 15s.

The Church is dedicated to St. Botolph, and is a regular pile, with a nave, 2 isles, and a chancel covered with lead, and has a tower with 4 bells.

In the chancel, on a little monument,

Lancelotus Thexton cappellanus Regis Edw. VI. sacre theologie baccalaureus, et rector de Trunch obt. 25. Febr. 1588, and this shield of arms, quarterly, in the first and fourth a cross between four lions heads erased, gules, in the 2d and 3d, ermine, fretty, azure.

In a window here, argent, a fess between two chevrons, sable.

On a gravestone

Hic jacet Magr. Robt. Cantell, quo'd. rector isti. ecclie, qui. obt. 1 Sept. Ao. Dni. 1480.

Gravestones

In memory of Thomas Worts, gent. who died November 13, 1693, aged 45, with his arms, three lions rampant, - - - — William Worts. gent. who married Elizabeth, daughter of Riches Brown of Fulmodeston, Esq. died August 25, 1694, aged 60, with the arms of Worts impaling Brown; two bars, between three spears heads, - - -

¶The patronage of the church was granted to the priory of Castleacre, by William Earl Warren, the first on his founding that priory. In the reign of Edward I. the rector had a manse, and 13 acres of land valued at 16 marks, Peter-pence 13d. and the prior of Castleacre had a pension or portion of tithe valued at 40s. the present valor is 10l. 13s. 4d. and pays first fruits, &c. the Norwich registers say that William, the second Earl Warren, granted the patronage, and Eborard Bishop of Norwich, confirmed it; and that Simon the Bishop confirmed the pension in 1268.

www.british-history.ac.uk/topographical-hist-norfolk/vol8...

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Trunch is the largest of the villages between North Walsham and the sea; but as all the industrialisation and tawdry caravan sites are hard against the coast, and Trunch is several miles inland, it has avoided these excesses and retains a great rural charm. It has a magnificent church with lots of fascinating treasures, as well as a shop, a green, a pub run by an ex-professional footballer, and generally all the typical features you expect to find in a large village in deepest rural Norfolk.

The church is perhaps the most interesting of all round about; and, while the large village lends it an urban quality that lacks the charm of, say, the churches of neighbouring Edingthorpe and Crostwight, it has by no means the Victorianised sterility of those at Bacton or Happisburgh.

St Botolph is a big church, and its tight graveyard makes it rather hard to photograph. The whole piece seems to have been rebuilt in the early 15th century, although the chancel may be a little later, and there is a hint of Decorated about the nave. The tower is quite simple, even slight. It builds boldly enough, but at the top of the second stage fades into a simple bell stage, understated, elegant and probably intended. This is not a building that shouts at you. A curiosity is the massive priest porch surrounding the door in the chancel. These are very unusual, although there is another, smaller one at neighbouring Knapton.

The great treasure, of course, is the marvellous font canopy. It is particularly fascinating because of its date, coming in the early 16th century right on the eve of the English protestant reformation. Like all church furnishings at this time - the tombs at Oxborough, for instance - it gives us a hint of what the English renaissance might have been like if it had been allowed to flower. Here, the massive structure tumbles with intricacy; fruit and flowers, leopards and lions peep around the silvery oak of the six octagonal columns which are fluted with interlocking chains of detail. The glory is the massive crown of canopied niches, with the haunting ghosts of crucifixion groups still apparent on three of the faces. The whole thing is at once in perfect harmony with the west end of the church, but exists because it was believed to be beautiful rather than known to be useful.There is only one other font canopy in Norfolk, at St Peter Mancroft in Norwich; Outside of the county there is another at Durham Cathedral, and a fourth at the parish church in Luton - but that is it.

Above the canopy is a rich 15th century hammerbeam roof, by no means as dramatic as that at nearby Knapton, but more beautiful, I think. In the space beneath the tower there is what appears to be a gallery like the plough guild gallery at Cawston. This is not as elaborate, but its oak has silvered and it is painted beautifully with trailing rose foliage.

The benching, unfortunately, is pretty much all 19th century, but along with the font canopy and roof the medieval screen survives. Like the canopy, this is richly ornamented in relief, including a bold dedicatory inscription in diagonal ribbons across the top part of the dado. The twelve figures (11 disciples and St Paul) are boldly placed and coloured, but their faces have been completely vandalised by the 16th century reformers. Low down on the north side of the doorway is a rare surviving carved consecration cross, suggesting that this screen was already installed in the newly built church of the 15th century. The screen had detached buttressing running vertically at intervals in front of it, as at Ludham. They have been almost entirely destroyed, but you can still see the fixings between the panels. It must have been magnificent.

The return stalls in the chancel are pretty much all Victorian, but they retain medieval misericords, and also you can see quatrefoil holes set into a sounding chamber to amplify the singing. There is a very curious memorial above the priest door, featuring the instruments of the passion. I have no idea how old it is.

All of these features would be enough, but part of the attraction of St Botolph is the sense of harmony, the way everything works together. You can add to these the sedilia, the magnificent organ, and the modern design of the glass in the east window. It is a peaceful, inspiring space.

Cottages and houses hem in the graveyard, and in the corner is the modern pub. Incidentally, I don't really know if the bloke who runs it is an ex-professional footballer. But, like many rural Norfolk landlords, he seems to be a cheerful 40-something cockney who serves a decent pint and cheap food - a recommended stop for churchcrawlers.

Simon Knott, April 2005

www.norfolkchurches.co.uk/trunch/trunch.htm

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And the pub is still good.

World leader, international leader, scientist, medical scientist, virologist, philosopher, thinker, cosmologist, sociologist, and Professor Fangruida by rs Vots

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World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5)

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The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021

*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety

*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)

——————————————————————————

(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021

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According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.

The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.

, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent

What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of the cell. The ribosome is the place where protein biosynthesis occurs.

Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.

Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell

(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology

(2) New crown vaccine design, molecular biology and chemical structure, etc.

(3) The generality and particularity of the development of new coronavirus drugs

(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.

(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.

(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities

(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.

(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.

(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.

(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus

(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and

The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.

(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,

Hepatitis virus,

Marburg virus

Sars coronavirus, plague, anthracnose, cholera

and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.

However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.

　　　　 Delta mutant strain

According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.

At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.

(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.

(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.

And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.

, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.

Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2～8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.

(2) Live attenuated vaccine: It is a vaccine made by using artificial targeted mutation methods or by screening live microorganisms with highly weakened or basically non-toxic virulence from the natural world. After inoculation, the live attenuated vaccine has a certain ability to grow and reproduce in the body, which can cause the body to have a reaction similar to a recessive infection or a mild infection, and it is widely used.

(3) Subunit vaccine: Among the multiple specific antigenic determinants carried by macromolecular antigens, only a small number of antigenic sites play an important role in the protective immune response. Separate natural proteins through chemical decomposition or controlled proteolysis, and extract bacteria and virusesVaccines made from fragments with immunological activity are screened out of the special protein structure of, called subunit vaccines. Subunit vaccines have only a few major surface proteins, so they can eliminate antibodies induced by many unrelated antigens, thereby reducing the side effects of the vaccine and related diseases and other side effects caused by the vaccine. (4) Genetically engineered vaccine: It uses DNA recombination biotechnology to direct the natural or synthetic genetic material in the pathogen coat protein that can induce the body's immune response into bacteria, yeast or mammalian cells to make it fully expressed. A vaccine prepared after purification. The application of genetic engineering technology can produce subunit vaccines that do not contain infectious substances, stable attenuated vaccines with live viruses as carriers, and multivalent vaccines that can prevent multiple diseases. This is the second-generation vaccine following the first-generation traditional vaccine. It has the advantages of safety, effectiveness, long-term immune response, and easy realization of combined immunization. It has certain advantages and effects.

New coronavirus drug development, drug targets and chemical modification.

Ligand-based drug design (or indirect drug design planning) relies on the knowledge of other molecules that bind to the target biological target. These other molecules can be used to derive pharmacophore models and structural modalities, which define the minimum necessary structural features that the molecule must have in order to bind to the target. In other words, a model of a biological target can be established based on the knowledge of the binding target, and the model can be used to design new molecular entities and other parts that interact with the target. Among them, the quantitative structure-activity relationship (QSAR) is included, in which the correlation between the calculated properties of the molecule and its experimentally determined biological activity can be derived. These QSAR relationships can be used to predict the activity of new analogs. The structure-activity relationship is very complicated.

Based on structure

Structure-based drug design relies on knowledge of the three-dimensional structure of biological targets obtained by methods such as X-ray crystallography or NMR spectroscopy and quantum chemistry. If the experimental structure of the target is not available, it is possible to create a homology model of the target and other standard models that can be compared based on the experimental structure of the relevant protein. Using the structure of biological targets, interactive graphics and medical chemists’ intuitive design can be used to predict drug candidates with high affinity and selective binding to the target. Various automatic calculation programs can also be used to suggest new drug candidates.

The current structure-based drug design methods can be roughly divided into three categories. The 3D method is to search a large database of small molecule 3D structures to find new ligands for a given receptor, in order to use a rapid approximate docking procedure to find those suitable for the receptor binding pocket. This method is called virtual screening. The second category is the de novo design of new ligands. In this method, by gradually assembling small fragments, a ligand molecule is established within the constraints of the binding pocket. These fragments can be single atoms or molecular fragments. The main advantage of this method is that it can propose novel structures that are not found in any database. The third method is to optimize the known ligand acquisition by evaluating the proposed analogs in the binding cavity.

Bind site ID

Binding site recognition is a step in structure-based design. If the structure of the target or a sufficiently similar homologue is determined in the presence of the bound ligand, the ligand should be observable in that structure, in which case the location of the binding site is small. However, there may not be an allosteric binding site of interest. In addition, only apo protein structures may be available, and it is not easy to reliably identify unoccupied sites that have the potential to bind ligands with high affinity. In short, the recognition of binding sites usually depends on the recognition of pits. The protein on the protein surface can hold molecules the size of drugs, etc. These molecules also have appropriate "hot spots" that drive ligand binding, hydrophobic surfaces, hydrogen bonding sites, and so on.

Drug design is a creative process of finding new drugs based on the knowledge of biological targets. The most common type of drug is small organic molecules that activate or inhibit the function of biomolecules, thereby producing therapeutic benefits for patients. In the most important sense, drug design involves the design of molecules with complementary shapes and charges that bind to their interacting biomolecular targets, and therefore will bind to them. Drug design often but does not necessarily rely on computer modeling techniques. A more accurate term is ligand design. Although the design technology for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, etc., which must be optimized first before the ligand can become safe and effective. drug. These other features are usually difficult to predict and realize through reasonable design techniques. However, due to the high turnover rate, especially in the clinical stage of drug development, in the early stage of the drug design process, more attention is paid to the selection of drug candidates. The physical and chemical properties of these drug candidates are expected to be reduced during the development process. Complications are therefore more likely to lead to the approval of the marketed drug. In addition, in early drug discovery, in vitro experiments with computational methods are increasingly used to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological characteristics. A more accurate term is ligand design. Although the design technique for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, iatrogenic effects, etc., which must be optimized first, and then the ligand To become safe and effective.

For drug targets, two aspects should be considered when selecting drug targets:

1. The effectiveness of the target, that is, the target is indeed related to the disease, and the symptoms of the disease can be effectively improved by regulating the physiological activity of the target.

2. The side effects of the target. If the regulation of the physiological activity of the target inevitably produces serious side effects, it is inappropriate to select it as the target of drug action or lose its important biological activity. The reference frame of the target should be expanded in multiple dimensions to have a big choice.

3. Search for biomolecular clues related to diseases: use genomics, proteomics and biochip technology to obtain biomolecular information related to diseases, and perform bioinformatics analysis to obtain clue information.

4. Perform functional research on related biomolecules to determine the target of candidate drugs. Multiple targets or individual targets.

5. Candidate drug targets, design small molecule compounds, and conduct pharmacological research at the molecular, cellular and overall animal levels.

Covalent bonding type

The covalent bonding type is an irreversible form of bonding, similar to the organic synthesis reaction that occurs. Covalent bonding types mostly occur in the mechanism of action of chemotherapeutic drugs. For example, alkylating agent anti-tumor drugs produce covalent bonding bonds to guanine bases in DNA, resulting in cytotoxic activity.

. Verify the effectiveness of the target.

Based on the targets that interact with drugs, that is, receptors in a broad sense, such as enzymes, receptors, ion channels, membranes, antigens, viruses, nucleic acids, polysaccharides, proteins, enzymes, etc., find and design reasonable drug molecules. Targets of action and drug screening should focus on multiple points. Drug intermediates and chemical modification. Combining the development of new drugs with the chemical structure modification of traditional drugs makes it easier to find breakthroughs and develop new antiviral drugs. For example, careful selection, modification and modification of existing related drugs that can successfully treat and recover a large number of cases, elimination and screening of invalid drugs from severe death cases, etc., are targeted, rather than screening and capturing needles in a haystack, aimless, with half the effort. Vaccine design should also be multi-pronged and focused. The broad-spectrum, long-term, safety, efficiency and redundancy of the vaccine should all be considered. In this way, it will be more powerful to deal with the mutation and evolution of the virus. Of course, series of vaccines, series of drugs, second-generation vaccines, third-generation vaccines, second-generation drugs, third-generation drugs, etc. can also be developed. Vaccines focus on epidemic prevention, and medicines focus on medical treatment. The two are very different; however, the two complement each other and complement each other. Therefore, in response to large-scale epidemics of infectious diseases, vaccines and various drugs are the nemesis and killers of viral diseases. Of course, it also includes other methods and measures, so I won't repeat them here.

Mainly through the comprehensive and accurate understanding of the structure of the drug and the receptor at the molecular level and even the electronic level, structure-based drug design and the understanding of the structure, function, and drug action mode of the target and the mechanism of physiological activity Mechanism-based drug design.

Compared with the traditional extensive pharmacological screening and lead compound optimization, it has obvious advantages.

Viral RNA replicase, also known as RNA-dependent RNA polymerase (RdRp) is responsible for the replication and transcription of RNA virus genome, and plays a very important role in the process of virus self-replication in host cells, and It also has a major impact on the mutation of the virus, it will change and accelerate the replication and recombination. Because RdRp from different viruses has a highly conserved core structure, the virus replicase is an important antiviral drug target and there are other selection sites, rather than a single isolated target target such as the new coronavirus As with various mutant viruses, inhibitors developed for viral replicase are expected to become a broad-spectrum antiviral drug. The currently well-known anti-coronavirus drug remdesivir (remdesivir) is a drug for viral replicase.

New antiviral therapies are gradually emerging. In addition to traditional polymerase and protease inhibitors, nucleic acid drugs, cell entry inhibitors, nucleocapsid inhibitors, and drugs targeting host cells are also increasingly appearing in the research and development of major pharmaceutical companies. The treatment of mutated viruses is becoming increasingly urgent. The development of drugs for the new coronavirus pneumonia is very important. It is not only for the current global new coronavirus epidemic, but more importantly, it is of great significance to face the severe pneumonia-respiratory infectious disease that poses a huge threat to humans.

There are many vaccines and related drugs developed for the new coronavirus pneumonia, and countries are vying for a while, mainly including the following:

Identification test, appearance, difference in loading, moisture, pH value, osmolality, polysaccharide content, free polysaccharide content, potency test, sterility test, pyrogen test, bacterial endotoxin test, abnormal toxicity test.

Among them: such as sterility inspection, pyrogen inspection, bacterial endotoxin, and abnormal toxicity inspection are indicators closely related to safety.

Polysaccharide content, free polysaccharide content, and efficacy test are indicators closely related to vaccine effectiveness.

Usually, a vaccine will go through a long research and development process of at least 8 years or even more than 20 years from research and development to marketing. The outbreak of the new crown epidemic requires no delay, and the design and development of vaccines is speeding up. It is not surprising in this special period. Of course, it is understandable that vaccine design, development and testing can be accelerated, shortened the cycle, and reduced some procedures. However, science needs to be rigorous and rigorous to achieve great results. The safety and effectiveness of vaccines are of the utmost importance. There must not be a single error. Otherwise, it will be counterproductive and need to be continuously improved and perfected.

Pre-clinical research: The screening of strains and cells is the basic guarantee to ensure the safety, effectiveness, and continuous supply of vaccines. Taking virus vaccines as an example, the laboratory stage needs to carry out strain screening, necessary strain attenuation, strain adaptation to the cultured cell matrix and stability studies in the process of passaging, and explore the stability of process quality, establish animal models, etc. . Choose mice, guinea pigs, rabbits or monkeys for animal experiments according to each vaccine situation. Pre-clinical research generally takes 5-10 years or longer on the premise that the process is controllable, the quality is stable, and it is safe and effective. In order to be safe and effective, a certain redundant design is also needed, so that the safety and effectiveness of the vaccine can be importantly guaranteed.

These include the establishment of vaccine strain/cell seed bank, production process research, quality research, stability research, animal safety evaluation and effectiveness evaluation, and clinical trial programs, etc.

The ARS-CoV-2 genome contains at least 10 ORFs. ORF1ab is converted into a polyprotein and processed into 16 non-structural proteins (NSP). These NSPs have a variety of functional biological activities, physical and chemical reactions, such as genome replication, induction of host mRNA cleavage, membrane rearrangement, autophagosome production, NSP polyprotein cleavage, capping, tailing, methylation, RNA double-stranded Uncoiling, etc., and others, play an important role in the virus life cycle. In addition, SARS-CoV-2 contains 4 structural proteins, namely spike (S), nucleocapsid (N), envelope (E) and membrane (M), all of which are encoded by the 3'end of the viral genome. Among the four structural proteins, S protein is a large multifunctional transmembrane protein that plays an important role in the process of virus adsorption, fusion, and injection into host cells, and requires in-depth observation and research.

1S protein is composed of S1 and S2 subunits, and each subunit can be further divided into different functional domains. The S1 subunit has 2 domains: NTD and RBD, and RBD contains conservative RBM. The S2 subunit has 3 structural domains: FP, HR1 and HR2. The S1 subunit is arranged at the top of the S2 subunit to form an immunodominant S protein.

The virus uses the host transmembrane protease Serine 2 (TMPRSS2) and the endosomal cysteine protease CatB/L to enter the cell. TMPRSS2 is responsible for the cleavage of the S protein to expose the FP region of the S2 subunit, which is responsible for initiating endosome-mediated host cell entry into it. It shows that TMPRSS2 is a host factor necessary for virus entry. Therefore, the use of drugs that inhibit this protease can achieve the purpose of treatment.

mRNA-1273

The mRNA encoding the full length of SARS-CoV-2, and the pre-spike protein fusion is encapsulated into lipid nanoparticles to form mRNA-1273 vaccine. It can induce a high level of S protein specific antiviral response. It can also consist of inactivated antigens or subunit antigens. The vaccine was quickly approved by the FDA and has entered phase II clinical trials. The company has announced the antibody data of 8 subjects who received different immunization doses. The 25ug dose group achieved an effect similar to the antibody level during the recovery period. The 100ug dose group exceeded the antibody level during the recovery period. In the 25ug and 100ug dose groups, the vaccine was basically safe and tolerable, while the 250ug dose group had 3 levels of systemic symptoms.

Viral vector vaccines can provide long-term high-level expression of antigen proteins, induce CTLs, and ultimately eliminate viral infections.

1, Ad5-nCov

A vaccine of SARS-CoV-2 recombinant spike protein expressed by recombinant, replication-deficient type 5 adenovirus (Ad5) vector. Load the optimized full-length S protein gene together with the plasminogen activation signal peptide gene into the E1 and E3 deleted Ad5 vectors. The vaccine is constructed by the Admax system derived from Microbix Biosystem. In phase I clinical trials, RBD (S1 subunit receptor binding domain) and S protein neutralizing antibody increased by 4 times 14 days after immunization, reaching a peak on 28 days. CD4+T and CD8+T cells reached a peak 14 days after immunization. The existing Ad5 immune resistance partially limits the response of antibodies and T cells. This study will be further conducted in the 18-60 age group, receiving 1/3 of the study dose, and follow-up for 3-6 months after immunization.

DNA vaccine

The introduction of antigen-encoding DNA and adjuvants as vaccines is the most innovative vaccine method. The transfected cells stably express the transgenic protein, similar to live viruses. The antigen will be endocytosed by immature DC, and finally provide antigen to CD4 + T, CD8 + T cells (by MHC differentiation) To induce humoral and cellular immunity. Some specificities of the virus and the new coronavirus mutant are different from general vaccines and other vaccines. Therefore, it is worth noting the gene expression of the vaccine. Otherwise, the effectiveness and efficiency of the vaccine will be questioned.

Live attenuated vaccine

DelNS1-SARS-CoV2-RBD

Basic influenza vaccine, delete NS1 gene. Express SARS-CoV-2 RBD domain. Cultured in CEF and MDCK (canine kidney cells) cells. It is more immunogenic than wild-type influenza virus and can be administered by nasal spray.

The viral genome is susceptible to mutation, antigen transfer and drift can occur, and spread among the population. Mutations can vary depending on the environmental conditions and population density of the geographic area. After screening and comparing 7,500 samples of infected patients, scientists found 198 mutations, indicating the evolutionary mutation of the virus in the human host. These mutations may form different virus subtypes, which means that even after vaccine immunization, viral infections may occur. A certain amount of increment and strengthening is needed here.

Inactivated vaccines, adenovirus vector vaccines, recombinant protein vaccines, nucleic acid vaccines, attenuated influenza virus vector vaccines, etc. According to relevant information, there are dozens of new coronavirus vaccines in the world, and more varieties are being developed and upgraded. Including the United States, Britain, China, Russia, India and other countries, there are more R&D and production units.

AZ vaccine

Modena vaccine

Lianya Vaccine

High-end vaccine

Pfizer vaccine

Pfizer-BioNTech

A large study found that the vaccine developed by Pfizer and German biotechnology company BioNTech is 95% effective in preventing COVID-19.

The vaccine is divided into two doses, which are injected every three weeks.

This vaccine uses a molecule called mRNA as its basis. mRNA is a molecular cousin of DNA, which contains instructions to build specific proteins; in this case, the mRNA in the vaccine encodes the coronavirus spike protein, which is attached to the surface of the virus and used to infect human cells. Once the vaccine enters the human body, it will instruct the body's cells to make this protein, and the immune system will learn to recognize and attack it.

Moderna

The vaccine developed by the American biotechnology company Moderna and the National Institute of Allergy and Infectious Diseases (NIAID) is also based on mRNA and is estimated to be 94.5% effective in preventing COVID-19.

Like Pfizer's vaccine, this vaccine is divided into two doses, but injected every four weeks instead of three weeks. Another difference is that the Moderna vaccine can be stored at minus 20 degrees Celsius instead of deep freezing like Pfizer vaccine. At present, the importance of one of the widely used vaccines is self-evident.

Oxford-AstraZeneca

The vaccine developed by the University of Oxford and the pharmaceutical company AstraZeneca is approximately 70% effective in preventing COVID-19-that is, in clinical trials, adjusting the dose seems to improve this effect.

In the population who received two high-dose vaccines (28 days apart), the effectiveness of the vaccine was about 62%; according to early analysis, the effectiveness of the vaccine in those patients who received the half-dose first and then the full-dose Is 90%. However, in clinical trials, participants taking half doses of the drug are wrong, and some scientists question whether these early results are representative.

Sinopharm Group (Beijing Institute of Biological Products, China)

China National Pharmaceutical Group Sinopharm and Beijing Institute of Biological Products have developed a vaccine from inactivated coronavirus (SARS-CoV-2). The inactivated coronavirus is an improved version that cannot be replicated.

Estimates of the effectiveness of vaccines against COVID-19 vary.

Gamaleya Institute

The Gamaleya Institute of the Russian Ministry of Health has developed a coronavirus vaccine candidate called Sputnik V. This vaccine contains two common cold viruses, adenoviruses, which have been modified so that they will not replicate in the human body; the modified virus also contains a gene encoding the coronavirus spike protein.

New crown drugs

There are many small molecule antiviral drug candidates in the clinical research stage around the world. Including traditional drugs in the past and various drugs yet to be developed, antiviral drugs, immune drugs, Gene drugs, compound drugs, etc.

(A) Molnupiravir

Molnupiravir is a prodrug of the nucleoside analog N4-hydroxycytidine (NHC), jointly developed by Merck and Ridgeback Biotherapeutics.

The positive rate of infectious virus isolation and culture in nasopharyngeal swabs was 0% (0/47), while that of patients in the placebo group was 24% (6/25). However, data from the Phase II/III study indicate that the drug has no benefit in preventing death or shortening the length of stay in hospitalized patients.

Therefore, Merck has decided to fully advance the research of 800mg molnupiravir in the treatment of patients with mild to moderate COVID-19.

(B) AT-527

AT-527 is a small molecule inhibitor of viral RNA polymerase, jointly developed by Roche and Atea. Not only can it be used as an oral therapy to treat hospitalized COVID-19 patients, but it also has the potential as a preventive treatment after exposure.

Including 70 high-risk COVID-19 hospitalized patients data, of which 62 patients' data can be used for virological analysis and evaluation. The results of interim virological analysis show that AT-527 can quickly reduce viral load. On day 2, compared with placebo, patients treated with AT-527 had a greater decline in viral load than the baseline level, and the continuous difference in viral load decline was maintained until day 8.

In addition, compared with the control group, the potent antiviral activity of AT-527 was also observed in patients with a baseline median viral load higher than 5.26 log10. When testing by RT-qPCR to assess whether the virus is cleared,

The safety aspect is consistent with previous studies. AT-527 showed good safety and tolerability, and no new safety problems or risks were found. Of course, there is still a considerable distance between experiment and clinical application, and a large amount of experimental data can prove it.

(C) Prokrutamide

Prokalamide is an AR (androgen receptor) antagonist. Activated androgen receptor AR can induce the expression of transmembrane serine protease (TMPRSS2). TMPRSS2 has a shearing effect on the new coronavirus S protein and ACE2, which can promote the binding of viral spike protein (S protein) to ACE, thereby promoting The virus enters the host cell. Therefore, inhibiting the androgen receptor may inhibit the viral infection process, and AR antagonists are expected to become anti-coronavirus drugs.

Positive results were obtained in a randomized, double-blind, placebo-controlled phase III clinical trial. The data shows that Prokalutamide reduces the risk of death in severely ill patients with new coronary disease by 92%, reduces the risk of new ventilator use by 92%, and shortens the length of hospital stay by 9 days. This shows that procrulamide has a certain therapeutic effect for patients with severe new coronary disease, which can significantly reduce the mortality of patients, and at the same time greatly reduce the new mechanical ventilation and shorten the patient's hospital stay.

With the continuous development of COVID-19 on a global scale, in addition to vaccines and prevention and control measures, we need a multi-pronged plan to control this disease. Oral antiviral therapy undoubtedly provides a convenient treatment option.

In addition, there are other drugs under development and experimentation. In dealing with the plague virus, in addition to the strict control of protective measures, it is very important that various efficient and safe vaccines and various drugs (including medical instruments, etc.) are the ultimate nemesis and killer of the virus.

(A) "Antiviral biological missiles" are mainly drugs for new coronaviruses and mutant viruses, which act on respiratory and lung diseases. The drugs use redundant designs to inhibit new coronaviruses and variant viruses.

(B) "New Coronavirus Epidemic Prevention Tablets" mainly use natural purified elements and chemical structure modifications.

(C) "Composite antiviral oral liquid" antiviral intermediate, natural antiviral plant, plus other preparations

(D) "New Coronavirus Long-acting Oral Tablets" Chemical modification of antiviral drugs, multiple targets, etc.

(E) "New Coronavirus Inhibitors" (injections) are mainly made of chemical drug structure modification and other preparations.

The development of these drugs mainly includes: drug target screening, structure-activity relationship, chemical modification, natural purification, etc., which require a lot of work and experimentation.

Humans need to vigorously develop drugs to deal with various viruses. These drugs are very important for the prevention and treatment of viruses and respiratory infectious diseases, influenza, pneumonia, etc.

The history of human development The history of human evolution, like all living species, will always be accompanied by the survival and development of microorganisms. It is not surprising that viruses and infectious diseases are frequent and prone to occur. The key is to prevent and control them before they happen.

This strain was first discovered in India in October 2020 and was initially called a "double mutant" virus by the media. According to the announcement by the Ministry of Health of India at the end of March this year, the "India New Coronavirus Genomics Alliance" composed of 10 laboratories found in samples collected in Maharashtra that this new mutant strain carries E484Q and L452R mutations. , May lead to immune escape and increased infectivity. This mutant strain was named B.1.617 by the WHO and was named with the Greek letter δ (delta) on May 31.

Shahid Jamil, the dean of the Trivedi School of Biological Sciences at Ashoka University in India and a virologist, said in an interview with the Shillong Times of India that this mutant strain called "double mutation" is not accurate enough. B. 1.617 contains a total of 15 mutations, of which 6 occur on the spike protein, of which 3 are more critical: L452R and E484Q mutations occur on the spike protein and the human cell "Angiotensin Converting Enzyme 2 (ACE2)" receptor In the bound region, L452R improves the ability of the virus to invade cells, and E484Q helps to enhance the immune escape of the virus; the third mutation P681R can also make the virus enter the cell more effectively. (Encyclopedia website)

There are currently dozens of antiviral COVID-19 therapies under development. The large drugmakers Merck and Pfizer are the closest to the end, as expected, a pair of oral antiviral COVID-19 therapies are undergoing advanced human clinical trials.

Merck's drug candidate is called monupiravir. It was originally developed as an influenza antiviral drug several years ago. However, preclinical studies have shown that it has a good effect on SARS and MERS coronavirus.

Monupiravir is currently undergoing in-depth large-scale Phase 3 human trials. So far, the data is so promising that the US government recently pre-ordered 1.7 million courses of drugs at a cost of $1.2 billion. If everything goes according to plan, the company hopes that the drug will be authorized by the FDA for emergency use and be on the market before the end of 2021.

Pfizer's large COVID-19 antiviral drug candidate is more unique. Currently known as PF-07321332, this drug is the first oral antiviral drug to enter human clinical trials, specifically targeting SARS-CoV-2.

Variant of Concern WHO Label First Detected in World First Detected in Washington State

B.1.1.7 Alpha United Kingdom, September 2020 January 2021

B.1.351 Beta South Africa, December 2020 February 2021

P.1 Gamma Brazil, April 2020 March 2021

B.1.617.2 Delta India, October 2020 April 2021

Although this particular molecule was developed in 2020 after the emergence of the new coronavirus, a somewhat related drug called PF-00835231 has been in operation for several years, targeting the original SARS virus. However, the new drug candidate PF-07321332 is designed as a simple pill that can be taken under non-hospital conditions in the initial stages of SARS-CoV-2 infection.

"The protease inhibitor binds to a viral enzyme and prevents the virus from replicating in the cell," Pfizer said when explaining the mechanism of its new antiviral drug. "Protease inhibitors have been effective in the treatment of other viral pathogens, such as HIV and hepatitis C virus, whether used alone or in combination with other antiviral drugs. Currently marketed therapeutic drugs for viral proteases are generally not toxic Therefore, such molecules may provide well-tolerated treatments against COVID-19."

Various studies on other types of antiviral drugs are also gaining momentum. For example, the new coronavirus pneumonia "antiviral biological missile", "new coronavirus prevention tablets", "composite antiviral oral liquid", "new coronavirus long-acting oral tablets", "new coronavirus inhibitors" (injections), etc., are worthy of attention. Like all kinds of vaccines, they will play a major role in preventing and fighting epidemics.

In addition, Japanese pharmaceutical company Shionoyoshi Pharmaceutical is currently conducting a phase 1 trial of a protease inhibitor similar to SARS-CoV-2. This is called S-217622, which is another oral antiviral drug, and hopes to provide people with an easy-to-take pill in the early stages of COVID-19. At present, the research and development of vaccines and various new crown drugs is very active and urgent. Time does not wait. With the passage of time, various new crown drugs will appear on the stage one after another, bringing the gospel to the complete victory of mankind.

The COVID-19 pandemic is far from over. The Delta mutant strain has quickly become the most prominent SARS-CoV-2 strain in the world. Although our vaccine is still maintained, it is clear that we need more tools to combat this new type of coronavirus. Delta will certainly not be the last new SARS-CoV-2 variant we encountered. Therefore, it is necessary for all mankind to persevere and fight the epidemic together.

Overcome illness and meet new challenges. The new crown epidemic and various mutated viruses are very important global epidemic prevention and anti-epidemic top priorities, especially for the current period of time. Vaccine injections, research and development of new drugs, strict prevention and control, wear masks, reduce gatherings, strictly control large gatherings, prevent the spread of various viruses Masks, disinfection and sterilization, lockdown of the city, vaccinations, accounting and testing are very important, but this does not mean that humans can completely overcome the virus. In fact, many spreading and new latently transmitted infections are still unsuccessful. There are detections, such as invisible patients, asymptomatic patients, migratory latent patients, new-onset patients, etc. The struggle between humans and the virus is still very difficult and complicated, and long-term efforts and exploration are still needed, especially for medical research on the new coronavirus. The origin of the disease, the course of the disease, the virus invaded The deep-level path and the reasons for the evolution and mutation of the new coronavirus and the particularity of prevention and treatment, etc.). Therefore, human beings should be highly vigilant and must not be taken lightly. The fierce battle between humans and various viruses must not be slackened. Greater efforts are needed to successfully overcome this pandemic, fully restore the normal life of the whole society, restore the normal production and work order, restore the normal operation of society, economy and culture, and give up food due to choking. Or eager for success, will pay a high price.

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References References are made to web resources, and related images are from web resources and related websites.

Who official website UN .org www.gavi.org/ispe.org

Wikipedia, "The Lancet", "English Journal of Medicine", "Nature", "Science", "Journal of the American Medical Association", etc.

Learning from history: do not flatten the curve of antiviral research!

T Bobrowski, CC Melo-Filho, D Korn, VM Alves...-Drug discovery today, 2020-

go.drugbank.com/

A critical overview of computational approaches employed for COVID-19 drug discovery

EN Muratov, R Amaro, CH Andrade, N Brown...-Chemical Society..., 2021-pubs.rsc.org

Global Research Performance on COVID 19 in Dimensions Database

J Balasubramani, M Anbalagan-2021-researchgate.net

Adoption of a contact tracing app for containing COVID-19: a health belief model approach

M Walrave, C Waeterloos...- JMIR public health and..., 2020-publichealth.jmir.org

Prophylactic Treatment Protocol Against the Severity of COVID-19 Using Melatonin

N Charaa, M Chahed, H Ghedira...-Available at SSRN..., 2020-papers.ssrn.com

　Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet

　Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany, New England Journal of Medicine

The actions of respiratory therapists facing COVID-19

Zhu Jiacheng-Respiratory Therapy, 2021-pesquisa.bvsalud.org

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, The Lancet

　Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China, JAMA, February 7

Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China, JAMA

Delta variant triggers new phase in the pandemic | Science

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COVID vaccines slash viral spread – but Delta is an unknown

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Novel coronavirus pneumonia during ophthalmic surgery management strategy and recommendations

YH HUANG, SS LI, X YAO, YR YANG, DH QIN…-jnewmed.com

Delta variant: What is happening with transmission, hospital ...

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Risk of long QT syndrome in novel coronavirus COVID-19

VN Oslopov, JV Oslopova, EV Hazova…-Kazan medical…, 2020-kazanmedjournal.ru

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First molecular-based detection of SARS-CoV-2 virus in the field-collected houseflies

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Covid 19 DELTA Variant Archives-Online essay writing service

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SARS-CoV-2 Delta variant Likely to become dominant in the ...

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Compilation postscript

Once Fang Ruida's research literature on the new crown virus and mutant virus was published, it has been enthusiastically praised by readers and netizens in dozens of countries around the world, and has proposed some amendments and suggestions. Hope to publish a multilingual version of the book as an emergency To meet the needs of many readers around the world, in the face of the new crown epidemic and the prevention and treatment of various mutant viruses, including the general public, college and middle school students, medical workers, medical colleagues and so on. According to the English original manuscript, it will be re-compiled and published. Inconsistencies will be revised separately. Thank you very much.

Jacques Lucy, Geneva, Switzerland, August 2021

*********************************************************************

Leader mondial, scientifique, scientifique médical, virologue, pharmacien et professeur Fangruida (F.D Smith) sur l'épidémie mondiale et l'ennemi juré et la prévention des nouveaux coronavirus et virus mutants (Jacques Lucy 2021v1.5)

_-----------------------------------------

L'ennemi juré et le tueur du nouveau coronavirus et des virus mutés - Développement conjoint de vaccins et de médicaments (Fangruida) Juillet 2021

* La particularité des nouveaux coronavirus et des virus mutants * Le large spectre, la haute efficacité, la redondance et la sécurité de la conception et du développement du nouveau vaccin contre le coronavirus, Redondance et sécurité

William R. Carter, Government Pharmacist for 40 Years by U.S. National Archives

50 5

Original Caption: "William R. Carter, Government Pharmacist for 40 Years. As [a] Laboratory Aide in the Food and Drug Administration of the Federal Security Agency, He Is Entrusted with the Job of Preparing Media for Testing the Sterility of Bandage Material."

U.S. National Archives’ Local Identifier: NWDNS-208-NP-4JJ-1

From: Series: Negro Activities in Industry, Government, and the Armed Forces (Record Group 208)

Created by: Office for Emergency Management. Office of War Information. Domestic Operations Branch. News Bureau, (06/13/1942 - 09/15/1945 )

Coverage Dates: ca. 1941 - ca. 1945

Photographer: Roger Smith

Subjects:

African Americans

World War, 1939-1945

Persistent URL: catalog.archives.gov/id/535823

Repository: Still Picture Records Section, Special Media Archives Services Division (NWCS-S), National Archives at College Park, 8601 Adelphi Road, College Park, MD, 20740-6001.

For information about ordering reproductions of photographs held by the Still Picture Unit, visit: www.archives.gov/research/order/still-pictures.html

Reproductions may be ordered via an independent vendor. NARA maintains a list of vendors at www.archives.gov/research/order/vendors-photos-maps-dc.html

Access Restrictions: Unrestricted

Use Restrictions: Unrestricted

Graveyard Angel by George Smyth

9 11

I have taken many pictures of graveyard angels over the years. I am not sure of the attraction, but if nothing else, it breaks up the sterility of more modern graveyards, which only allow plaques flush with the ground. This image was captured with infrared film, and close examination will reveal a bit of a halo surrounding the highlight area at the top of the head. This is due to the light traveling through the film, reflecting off the camera's back plane, and traveling back through the film a second time, due to the fact that Kodak's infrared film did not contain an anti-halation layer. Although not an angel, another graveyard image can be found at glsmyth.wordpress.com/2007/08/06/graveyard-figure/.

The bone relic of Saint Lucia , Martyr .From Vicarate of Rome. by Santi e Beati

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The bone relic of Saint Lucia arrived today(27th November 2012)from Vicarate of Rome. Many thanks to God for His gilf .

Life and works

Lucy's Latin name Lucia shares a root (luc-) with the Latin word for light, lux. "In 'Lucy' is said, the way of light" Jacobus de Voragine stated at the beginning of his vita of the Blessed Virgin Lucy, in Legenda Aurea, the most widely-read version of the Lucy legend in the Middle Ages.

Eutychia and Lucy at the Tomb of Saint Agatha, by Jacobello del Fiore

Because people wanted to shed light on Lucy's bravery and fortitude, legends grew up, reported in the acta that are associated with her name. All the details are conventional ones also associated with other female martyrs of the early 4th century.[6] Her Roman father died when she was young, leaving her and her mother without a protecting guardian. Her mother, Eutychia, had suffered four years with dysentery but Lucy had heard the renown of Saint Agatha, the patroness of Catania, "and when they were at a Mass, one read a gospel that made mention of a woman who was healed of the dysentery by touching of the hem of the coat of Jesus Christ," which, according to the Legenda Aurea, convinced her mother to pray together at Saint Agatha's tomb. They stayed up all night praying, until they fell asleep, exhausted. Saint Agatha appeared in a vision to Lucy and said, "Soon you shall be the glory of Syracuse, as I am of Catania." At that instant Eutychia was cured.

Eutychia had arranged a marriage for Lucy with a pagan bridegroom, but Lucy urged that the dowry be spent on alms so that she might retain her virginity. Euthychia suggested that the sums would make a good bequest, but Lucy countered, "...whatever you give away at death for the Lord's sake you give because you cannot take it with you. Give now to the true Savior, while you are healthy, whatever you intended to give away at your death."[7] News that the patrimony and jewels were being distributed came to the ears of Lucy's betrothed, who heard from a chattering nurse that Lucy had found a nobler Bridegroom.

Lucy Before the Judge, by Lorenzo Lotto, 1523-32

Her rejected pagan bridegroom denounced Lucy as a Christian to the magistrate Paschasius, who ordered her to burn a sacrifice to the emperor's image. Lucy replied that she had given all that she had: "I offer to Him myself, let Him do with His offering as it pleases Him." Sentenced to be defiled in a brothel, Lucy asserted:

“No one's body is polluted so as to endanger the soul if it has not pleased the mind. If you were to lift my hand to your idol and so make me offer against my will, I would still be guiltless in the sight of the true God, who judges according to the will and knows all things. If now, against my will, you cause me to be polluted, a twofold purity will be gloriously imputed to me. You cannot bend my will to your purpose; whatever you do to my body, that cannot happen to me.[7]”

The Christian tradition states that when the guards came to take her away they found her so filled with the Holy Spirit that she was as stiff and heavy as a mountain; they could not move her even when they hitched her to a team of oxen. Even after she had a dagger through her throat, she prophesied against her persecutor. Unfounded, and absent in the many narratives and traditions, at least until the 15th century, is the story of Lucia tortured by eye-gouging. The emblem of the eyes on the cup, or plate, must be linked simply to popular devotion to her, as protector of sight, because of her name, Lucia (from the Latin word "lux" which means "light").[8][9] In paintings St. Lucy is frequently shown holding her eyes on a golden plate. Lucy was represented in Gothic art holding a dish with two eyes on it (illustration above). The legend concludes with God restoring Lucy's eyes.

Dante also mentions Lucia in Inferno Canto II as the messenger "of all cruelty the foe" sent to Beatrice from "The blessed Dame" (Divine Mercy), to rouse Beatrice to send Virgil to Dante's aid. She has instructed Virgil to guide Dante through Hell and Purgatory. Lucia is only referenced indirectly in Virgil's discourse within the narrative and doesn't appear. According to Robert Harrison, Professor in Italian Literature at Stanford University and Rachel Jacoff, Professor of Italian Studies at Wellesley, Lucia's appearance in this intermediary role is to reinforce the scene in which Virgil attempts to fortify Dante's courage to begin the journey through the Inferno.[10]

Lucy may also be seen as a figure of Illuminating Grace or Mercy or even Justice.[11] Nonetheless Dante obviously regarded Lucia with great reverence, placing her opposite Adam within the Mystic Rose in Canto XXXII of the Paradiso.

In Mark Musa's translation of Dante's Purgatorio, it is noted that Lucy was admired by an undesirable suitor for her beautiful eyes. To stay chaste she plucked out her own eyes, a great sacrifice for which God gave her a pair of even more beautiful eyes. It is said in Sweden that to vividly celebrate St. Lucy's Day will help one live the long winter days with enough light.

Lucy's name also played a large part in naming Lucy as a patron saint of the blind and those with eye-trouble. She was the patroness of Syracuse in Sicily, Italy.

[edit]Relics

Sigebert (1030–1112), a monk of Gembloux, in his sermo de Sancta Lucia, chronicled that her body lay undisturbed in Sicily for 400 years, before Faroald II, Duke of Spole to, captured the island and transferred the body to Corfinium in the Abruzzo, Italy. From there it was removed by the Emperor Otho I in 972 to Metz and deposited in the church of St. Vincent. It was from this shrine that an arm of the saint was taken to the monastery of Luitburg in the Diocese of Speyer - an incident celebrated by Sigebert himself in verse.

The subsequent history of the relics is not clear. On their capture of Constantinople in 1204, the French found some relics attributed to Saint Lucy in the city, and Enrico Dandolo, Doge of Venice, secured them for the monastery of St. George at Venice. In 1513 the Venetians presented to Louis XII of France the saint's head, which he deposited in the cathedral church of Bourges. Another account, however, states that the head was brought to Bourges from Rome where it had been transferred during the time when the relics rested in Corfinium. The remainder of the relics remain in Venice: they were transferred to the church of San Geremia when the church of Santa Lucia was demolished in the 19th century to make way for the new railway terminus. A century later, on 7 November 1981, thieves stole all her bones, except her head. Police recovered them five weeks later, on her feast day. Other parts of the corpse have found their way to Rome, Naples, Verona, Lisbon, Milan, as well as Germany and France.[12]

Saint Lucia procession in Sweden.

[edit]Popular celebration

Main article: Saint Lucy's Day

Her brief day was commonly thought to be the shortest day of the year, as can be seen in John Donne's poem, "A Nocturnal upon St. Lucie's Day, being the shortest day" (1627). The poem begins with: "'Tis the year's midnight, and it is the day's," and expresses, in a mourning piece, the withdrawal of the world-spirit into sterility and darkness, where "The world's whole sap is sunk.".[13]

This timing, and her name meaning light, is a factor in the particular devotion to St. Lucy in Scandinavian countries, where young girls dress as the saint in honor of the feast. A special devotion to St. Lucy is present in the Italian regions of Lombardy, Emilia-Romagna, Veneto, Trentino-Alto Adige, in the North of the country, and Sicily, in the South.

The feast is a Catholic celebrated holiday with roots that can be traced back to Sicily. On 13th of every December it is celebrated with large traditional feasts of home made pasta and various other Italian dishes, with a special dessert of wheat in hot chocolate milk. The large grains of soft wheat are representative of her eyes and are a treat only to be indulged in once a year.

In Omaha, Nebraska, the Santa Lucia Festival is celebrated each summer. It was founded in 1925 by Italian Immigrant Grazia Buonafede Caniglia, and continues to this day. A statue of Saint Lucy is paraded through the streets of downtown Omaha, along with a First class relic, made of the physical body of Saint Lucy.

Sterility by Susannah B

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Sterility

Jervaulx Abbey, North Yorkshire, England. by PHOTOGRAPHY by DM & DBM.

3 1

Jervaulx Abbey in East Witton, 14 miles north-west of the city of Ripon, was one of the great Cistercian abbeys of Yorkshire, England, dedicated to St Mary in 1156. It is a Grade I listed building.

The place name Jervaulx is first attested in 1145, where it appears as Jorvalle. The name is French for 'the Ure valley' and is perhaps a translation of the English 'Ure-dale', also known as Yoredale. The valley is now called Wensleydale.

Initially a Savigniac foundation out of Normandy, the abbey was later taken over by the Cistercian order from Burgundy and responsibility for it was taken by Byland Abbey. Founded in 1145 at Fors near Aysgarth, it was moved ten years later to a site a few miles away on the banks of the River Ure. In 1145, in the reign of King Stephen, Akarius Fitz Bardolph, who was Lord of Ravensworth, gave Peter de Quinciano, a monk from Savigny, land at Fors and Worton, in Wensleydale, to build a monastery of their order. The monastery there was successively called the Abbey of Fors, Jervaulx and Charity. Grange, 5 miles (8 km) west-north-west of Aysgarth, a hamlet in the township of Low Abbotside in the parish of Aysgarth, is the original site of Fors Abbey. After it was abandoned it was known by the name of Dale Grange and now by that of the Grange alone.

Serlo, then Abbot of Savigny, disapproved of the foundation, since it had been made without his knowledge and consent. He refused to supply it with monks from his abbey because of the great difficulties experienced by those he had previously sent to England. Therefore in a general chapter he proposed that it be transferred to the Abbey of Belland (Byland), which was closer and would be able to provide the assistance required by the new foundation. Monks were sent from Byland and after they had undergone great hardships because of the meagreness of their endowment and sterility of their lands Conan, son of Alan, 1st Earl of Richmond, greatly increased their revenues and in 1156 moved their monastery to its better location in East Witton. Here the monks erected a new church and monastery, which, like most of the Cistercian order, was dedicated to St Mary. At the height of its prosperity the abbey owned half of the valley and was renowned for breeding horses, a tradition that remains in Middleham to the present day. It was also the original home of Wensleydale cheese, originally made with ewes' milk. In 1279 Abbot Philip of Jervaulx was murdered by one of his monks. His successor, Abbot Thomas, was initially accused of the crime, but a jury later determined that he was not to blame, and another monk fled under outlawry.

According to John Speed, at the Dissolution it was valued at £455 10s. 5d. The last abbot, Adam Sedbergh, joined the Pilgrimage of Grace and was hanged at Tyburn in June 1537, when the monastic property was forfeited to the king.

The pulpitum screen with part of the stalls can now be seen at St Andrew's Church, Aysgarth, and a window was reused at St Gregory's parish church in Bedale.

As the monasteries kept people employed and from starving, the regional disturbances were occasioned by desperation, and, as the monastic system was not diocesan or provincial to make a swift transition within the nationalized episcopal system, there was no immediate resolution to tenant sufferings. Jervaulx, Byland and other Cistercian houses were as much attached to Savigny and Citeaux Abbey in the Duchy of Burgundy as Richmondshire and the Honour of Richmond generally were to the Duchy of Brittany, both establishments based in France but cut off owing to the Hundred Years' War and especially after the loss of the Pale of Calais.

The standing remains of the abbey include part of the church and claustral buildings and a watermill. The lordship of East Witton, including the site of the abbey, was granted by Henry VIII to Matthew Stuart, 4th Earl of Lennox, and Margaret, his wife, the king's niece, and after passing through various hands the property came into the possession of the Bruce family, one of whom was created Earl of Ailesbury in 1805. The estate was purchased from the trustees of Ernest Brudenell-Bruce, 3rd Marquess of Ailesbury, in 1887 by S. Cunliffe Lister Esq. of Swinton Park for £310,000. It was purchased by Major and Mrs W. V. Burdon in 1971. Their youngest son, Ian, now runs the abbey, the ruins of which are open to the public.

North Yorkshire is a ceremonial county in the Yorkshire and the Humber and North East regions of England. It borders County Durham to the north, the North Sea to the east, the East Riding of Yorkshire to the south-east, South Yorkshire to the south, West Yorkshire to the south-west, and Cumbria and Lancashire to the west. Northallerton is the county town.

The county is the largest in England by land area, at 9,020 km2 (3,480 sq mi), and has a population of 1,158,816. The largest settlements are Middlesbrough (174,700) in the north-east and the city of York (152,841) in the south. Middlesbrough is part of the Teesside built-up area, which extends into County Durham and has a total population of 376,663. The remainder of the county is rural, and the largest towns are Harrogate (73,576) and Scarborough (61,749). For local government purposes the county comprises four unitary authority areas — York, Middlesbrough, Redcar and Cleveland, and North Yorkshire — and part of a fifth, Stockton-on-Tees.

The centre of the county contains a wide plain, called the Vale of Mowbray in the north and Vale of York in the south. The North York Moors lie to the east, and south of them the Vale of Pickering is separated from the main plain by the Howardian Hills. The west of the county contains the Yorkshire Dales, an extensive upland area which contains the source of the River Ouse/Ure and many of its tributaries, which together drain most of the county. The Dales also contain the county's highest point, Whernside, at 2,415 feet (736 m).

North Yorkshire non-metropolitan and ceremonial county was formed on 1 April 1974 as a result of the Local Government Act 1972. It covered most of the North Riding of Yorkshire, as well as northern parts of the West Riding of Yorkshire, northern and eastern East Riding of Yorkshire and the former county borough of York. Northallerton, as the former county town for the North Riding, became North Yorkshire's county town. In 1993 the county was placed wholly within the Yorkshire and the Humber region.

Some areas which were part of the former North Riding were in the county of Cleveland for twenty-two years (from 1974 to 1996) and were placed in the North East region from 1993. On 1 April 1996, these areas (Middlesbrough, Redcar and Cleveland and Stockton borough south of the River Tees) became part of the ceremonial county as separate unitary authorities. These areas remain within the North East England region.

Also on 1 April 1996, the City of York non-metropolitan district and parts of the non-metropolitan county (Haxby and nearby rural areas) became the City of York unitary authority.

On 1 April 2023, the non-metropolitan county became a unitary authority. This abolished eight councils and extended the powers of the county council to act as a district council.

The York and North Yorkshire Combined Authority held its first meeting on 22 January 2024, assumed its powers on 1 February 2024 and the first mayor is to be elected in May 2024.

The geology of North Yorkshire is closely reflected in its landscape. Within the county are the North York Moors and most of the Yorkshire Dales, two of eleven areas in England and Wales to be designated national parks. Between the North York Moors in the east and the Pennine Hills. The highest point is Whernside, on the Cumbrian border, at 2,415 feet (736 m). A distinctive hill to the far north east of the county is Roseberry Topping.

North Yorkshire contains several major rivers. The River Tees is the most northerly, forming part of the border between North Yorkshire and County Durham in its lower reaches and flowing east through Teesdale before reaching the North Sea near Redcar. The Yorkshire Dales are the source of many of the county's major rivers, including the Aire, Lune, Ribble, Swale, Ure, and Wharfe.[10] The Aire, Swale, and Wharfe are tributaries of the Ure/Ouse, which at 208 km (129 mi) long is the sixth-longest river in the United Kingdom. The river is called the Ure until it meets Ouse Gill beck just below the village of Great Ouseburn, where it becomes the Ouse and flows south before exiting the county near Goole and entering the Humber estuary. The North York Moors are the catchment for a number of rivers: the Leven which flows north into the Tees between Yarm and Ingleby Barwick; the Esk flows east directly into the North Sea at Whitby as well as the Rye (which later becomes the Derwent at Malton) flows south into the River Ouse at Goole.

North Yorkshire contains a small section of green belt in the south of the county, which surrounds the neighbouring metropolitan area of Leeds along the North and West Yorkshire borders. It extends to the east to cover small communities such as Huby, Kirkby Overblow, and Follifoot before covering the gap between the towns of Harrogate and Knaresborough, helping to keep those towns separate.

The belt adjoins the southernmost part of the Yorkshire Dales National Park, and the Nidderdale AONB. It extends into the western area of Selby district, reaching as far as Tadcaster and Balne. The belt was first drawn up from the 1950s.

The city of York has an independent surrounding belt area affording protections to several outlying settlements such as Haxby and Dunnington, and it too extends into the surrounding districts.

North Yorkshire has a temperate oceanic climate, like most of the UK. There are large climate variations within the county. The upper Pennines border on a Subarctic climate. The Vale of Mowbray has an almost Semi-arid climate. Overall, with the county being situated in the east, it receives below-average rainfall for the UK. Inside North Yorkshire, the upper Dales of the Pennines are one of the wettest parts of England, where in contrast the driest parts of the Vale of Mowbray are some of the driest areas in the UK.

Summer temperatures are above average, at 22 °C. Highs can regularly reach up to 28 °C, with over 30 °C reached in heat waves. Winter temperatures are below average, with average lows of 1 °C. Snow and Fog can be expected depending on location. The North York Moors and Pennines have snow lying for an average of between 45 and 75 days per year. Sunshine is most plentiful on the coast, receiving an average of 1,650 hours a year. It reduces further west in the county, with the Pennines receiving 1,250 hours a year.

The county borders multiple counties and districts:

County Durham's County Durham, Darlington, Stockton (north Tees) and Hartlepool;

East Riding of Yorkshire's East Riding of Yorkshire;

South Yorkshire's City of Doncaster;

West Yorkshire's City of Wakefield, City of Leeds and City of Bradford;

Lancashire's City of Lancaster, Ribble Valley and Pendle

Cumbria's Westmorland and Furness.

The City of York Council and North Yorkshire Council formed the York and North Yorkshire Combined Authority in February 2024. The elections for the first directly-elected mayor will take place in May 2024. Both North Yorkshire Council and the combined authority are governed from County Hall, Northallerton.

The Tees Valley Combined Authority was formed in 2016 by five unitary authorities; Middlesbrough, Redcar and Cleveland Borough both of North Yorkshire, Stockton-on-Tees Borough (Uniquely for England, split between North Yorkshire and County Durham), Hartlepool Borough and Darlington Borough of County Durham.

In large areas of North Yorkshire, agriculture is the primary source of employment. Approximately 85% of the county is considered to be "rural or super sparse".

Other sectors in 2019 included some manufacturing, the provision of accommodation and meals (primarily for tourists) which accounted for 19 per cent of all jobs. Food manufacturing employed 11 per cent of workers. A few people are involved in forestry and fishing in 2019. The average weekly earnings in 2018 were £531. Some 15% of workers declared themselves as self-employed. One report in late 2020 stated that "North Yorkshire has a relatively healthy and diverse economy which largely mirrors the national picture in terms of productivity and jobs.

Mineral extraction and power generation are also sectors of the economy, as is high technology.

Tourism is a significant contributor to the economy. A study of visitors between 2013 and 2015 indicated that the Borough of Scarborough, including Filey, Whitby and parts of the North York Moors National Park, received 1.4m trips per year on average. A 2016 report by the National Park, states the park area gets 7.93 million visitors annually, generating £647 million and supporting 10,900 full-time equivalent jobs.

The Yorkshire Dales have also attracted many visitors. In 2016, there were 3.8 million visits to the National Park including 0.48 million who stayed at least one night. The parks service estimates that this contributed £252 million to the economy and provided 3,583 full-time equivalent jobs. The wider Yorkshire Dales area received 9.7 million visitors who contributed £644 million to the economy. The North York Moors and Yorkshire Dales are among England's best known destinations.

York is a popular tourist destination. A 2014 report, based on 2012 data, stated that York alone receives 6.9 million visitors annually; they contribute £564 million to the economy and support over 19,000 jobs. In the 2017 Condé Nast Traveller survey of readers, York rated 12th among The 15 Best Cities in the UK for visitors. In a 2020 Condé Nast Traveller report, York rated as the sixth best among ten "urban destinations [in the UK] that scored the highest marks when it comes to ... nightlife, restaurants and friendliness".

During February 2020 to January 2021, the average property in North Yorkshire county sold for £240,000, up by £8100 over the previous 12 months. By comparison, the average for England and Wales was £314,000. In certain communities of North Yorkshire, however, house prices were higher than average for the county, as of early 2021: Harrogate (average value: £376,195), Knaresborough (£375,625), Tadcaster (£314,278), Leyburn (£309,165) and Ripon (£299,998), for example.

This is a chart of trend of regional gross value added for North Yorkshire at current basic prices with figures in millions of British pounds sterling.

Unemployment in the county was traditionally low in recent years, but the lockdowns and travel restrictions necessitated by the COVID-19 pandemic had a negative effect on the economy during much of 2020 and into 2021. The UK government said in early February 2021 that it was planning "unprecedented levels of support to help businesses [in the UK] survive the crisis". A report published on 1 March 2021 stated that the unemployment rate in North Yorkshire had "risen to the highest level in nearly 5 years – with under 25s often bearing the worst of job losses".

York experienced high unemployment during lockdown periods. One analysis (by the York and North Yorkshire Local Enterprise Partnership) predicted in August 2020 that "as many as 13,835 jobs in York will be lost in the scenario considered most likely, taking the city's unemployment rate to 14.5%". Some critics claimed that part of the problem was caused by "over-reliance on the booming tourism industry at the expense of a long-term economic plan". A report in mid June 2020 stated that unemployment had risen 114 per cent over the previous year because of restrictions imposed as a result of the pandemic.

Tourism in the county was expected to increase after the restrictions imposed due the pandemic are relaxed. One reason for the expected increase is the airing of All Creatures Great and Small, a TV series about the vet James Herriot, based on a successful series of books; it was largely filmed within the Yorkshire Dales National Park. The show aired in the UK in September 2020 and in the US in early 2021. One source stated that visits to Yorkshire websites had increased significantly by late September 2020.

The East Coast Main Line (ECML) bisects the county stopping at Northallerton,Thirsk and York. Passenger service companies in the area are London North Eastern Railway, Northern Rail, TransPennine Express and Grand Central.

LNER and Grand Central operate services to the capital on the ECML, Leeds Branch Line and the Northallerton–Eaglescliffe Line. LNER stop at York, Northallerton and on to County Durham or spur over to the Tees Valley Line for Thornaby and Middlesbrough. The operator also branch before the county for Leeds and run to Harrogate and Skipton. Grand Central stop at York, Thirsk Northallerton and Eaglescliffe then over to the Durham Coast Line in County Durham.

Northern operates the remaining lines in the county, including commuter services on the Harrogate Line, Airedale Line and York & Selby Lines, of which the former two are covered by the Metro ticketing area. Remaining branch lines operated by Northern include the Yorkshire Coast Line from Scarborough to Hull, York–Scarborough line via Malton, the Hull to York Line via Selby, the Tees Valley Line from Darlington to Saltburn via Middlesbrough and the Esk Valley Line from Middlesbrough to Whitby. Last but certainly not least, the Settle-Carlisle Line runs through the west of the county, with services again operated by Northern.

The county suffered badly under the Beeching cuts of the 1960s. Places such as Richmond, Ripon, Tadcaster, Helmsley, Pickering and the Wensleydale communities lost their passenger services. Notable lines closed were the Scarborough and Whitby Railway, Malton and Driffield Railway and the secondary main line between Northallerton and Harrogate via Ripon.

Heritage railways within North Yorkshire include: the North Yorkshire Moors Railway, between Pickering and Grosmont, which opened in 1973; the Derwent Valley Light Railway near York; and the Embsay and Bolton Abbey Steam Railway. The Wensleydale Railway, which started operating in 2003, runs services between Leeming Bar and Redmire along a former freight-only line. The medium-term aim is to operate into Northallerton station on the ECML, once an agreement can be reached with Network Rail. In the longer term, the aim is to reinstate the full line west via Hawes to Garsdale on the Settle-Carlisle line.

York railway station is the largest station in the county, with 11 platforms and is a major tourist attraction in its own right. The station is immediately adjacent to the National Railway Museum.

The main road through the county is the north–south A1(M), which has gradually been upgraded in sections to motorway status since the early 1990s. The only other motorways within the county are the short A66(M) near Darlington and a small stretch of the M62 motorway close to Eggborough. The other nationally maintained trunk routes are the A168/A19, A64, A66 and A174.

Long-distance coach services are operated by National Express and Megabus. Local bus service operators include Arriva Yorkshire, Stagecoach, Harrogate Bus Company, The Keighley Bus Company, Scarborough & District (East Yorkshire), Yorkshire Coastliner, First York and the local Dales & District.

There are no major airports in the county itself, but nearby airports include Teesside International (Darlington), Newcastle and Leeds Bradford.

The main campus of Teesside University is in Middlesbrough, while York contains the main campuses of the University of York and York St John University. There are also two secondary campuses in the county: CU Scarborough, a campus of Coventry University, and Queen's Campus, Durham University in Thornaby-on-Tees.

Colleges

Middlesbrough College's sixth-form

Askham Bryan College of agriculture, Askham Bryan and Middlesbrough

Craven College, Skipton

Middlesbrough College

The Northern School of Art, Middlesbrough

Prior Pursglove College

Redcar & Cleveland College

Scarborough Sixth Form College

Scarborough TEC

Selby College

Stockton Riverside College, Thornaby

York College

Places of interest

Ampleforth College

Beningbrough Hall –

Black Sheep Brewery

Bolton Castle –

Brimham Rocks –

Castle Howard and the Howardian Hills –

Catterick Garrison

Cleveland Hills

Drax Power Station

Duncombe Park – stately home

Eden Camp Museum –

Embsay & Bolton Abbey Steam Railway –

Eston Nab

Flamingo Land Theme Park and Zoo –

Helmsley Castle –

Ingleborough Cave – show cave

John Smith's Brewery

Jorvik Viking Centre –

Lightwater Valley –

Lund's Tower

Malham Cove

Middleham Castle –

Mother Shipton's Cave –

National Railway Museum –

North Yorkshire Moors Railway –

Ormesby Hall – Palladian Mansion

Richmond Castle –

Ripley Castle – Stately home and historic village

Riverside Stadium

Samuel Smith's Brewery

Shandy Hall – stately home

Skipton Castle –

Stanwick Iron Age Fortifications –

Studley Royal Park –

Stump Cross Caverns – show cave

Tees Transporter Bridge

Theakston Brewery

Thornborough Henges

Wainman's Pinnacle

Wharram Percy

York Castle Museum –

Yorkshire Air Museum –

The Yorkshire Arboretum

Horseshoe Crab by Pearl Photo

8

Horseshoe crabs- important to the bio-medical industry because of their unique, copper-based blue blood contains a substance which coagulates in the presence of small amounts of bacterial toxins, is used to test for sterility of medical equipment and virtually all intravenous drugs.

India - Tamil Nadu - Chennai - Garlic - 59 by Manfred Sommer

3

Allium sativum, commonly known as garlic, is a species in the onion genus, Allium.

Its close relatives include the onion, shallot, leek, chive, and rakkyo. With a history of human use of over 7,000 years, garlic is native to central Asia, and has long been a staple in the Mediterranean region, as well as a frequent seasoning in Asia, Africa, and Europe. It was known to Ancient Egyptians, and has been used for both culinary and medicinal purposes.

DESCRIPTION

Allium sativum is a bulbous plant. It grows up to 1.2 m in height. Its hardiness is USDA Zone 8. It produces hermaphrodite flowers. Pollination occurs by bees and other insects.

ORIGIN AND MAJOR TYPES

Allium sativum grows in the wild in areas where it has become naturalized. The "wild garlic", "crow garlic", and "field garlic" of Britain are members of the species Allium ursinum, Allium vineale, and Allium oleraceum, respectively. Identification of the wild progenitor for common garlic is made difficult by the sterility of its many cultivars which may all be descended from the species, Allium longicuspis, growing wild in central and southwestern Asia.

In North America, Allium vineale (known as "wild garlic" or "crow garlic") and Allium canadense, known as "meadow garlic" or "wild garlic" and "wild onion", are common weeds in fields. One of the best-known "garlics", the so-called elephant garlic, is actually a wild leek (Allium ampeloprasum), and not a true garlic. Single clove garlic (also called pearl or solo garlic) originated in the Yunnan province of China.

EUROPEAN GARLIC

There are a number of garlics with Protected Geographical Status in Europe; these include:

- Aglio Rosso di Nubia (Red Garlic of Nubia) from Nubia-Paceco, Provincia di Trapani, Sicily, Italy

- Aglio Bianco Polesano from Veneto, Italy (PDO)

- Aglio di Voghiera from Ferrara, Emilia-Romagna, Italy (PDO)

- Ail blanc de Lomagne from Lomagne in the Gascony area of France (PGI)

- Ail de la Drôme from Drôme in France (PGI)

- Ail rose de Lautrec a rose/pink garlic from Lautrec in France (PGI)

- Ajo Morado de las Pedroñeras a rose/pink garlic from Las Pedroñeras in Spain (PGI)

SUBSPECIES AND VARIETIES

There are two subspecies of A. sativum, ten major groups of varieties, and hundreds of varieties or cultivars.

A. sativum var. ophioscorodon (Link) Döll, called Ophioscorodon, or hard necked garlic, includes porcelain garlics, rocambole garlic, and purple stripe garlics. It is sometimes considered to be a separate species, Allium ophioscorodon G.Don.

A. sativum var. sativum, or soft-necked garlic, includes artichoke garlic, silverskin garlic, and creole garlic.

CULTIVATION

Garlic is easy to grow and can be grown year-round in mild climates. While sexual propagation of garlic is indeed possible, nearly all of the garlic in cultivation is propagated asexually, by planting individual cloves in the ground. In cold climates, cloves are planted in the autumn, about six weeks before the soil freezes, and harvested in late spring. The cloves must be planted at sufficient depth to prevent freeze/thaw which causes mold or white rot. Garlic plants are usually very hardy, and are not attacked by many pests or diseases. Garlic plants are said to repel rabbits and moles. Two of the major pathogens that attack garlic are nematodes and white rot disease, which remain in the soil indefinitely after the ground has become infected. Garlic also can suffer from pink root, a typically nonfatal disease that stunts the roots and turns them pink or red.

Garlic plants can be grown closely together, leaving enough space for the bulbs to mature, and are easily grown in containers of sufficient depth. Garlic does well in loose, dry, well drained soils in sunny locations, and is hardy throughout USDA climate zones 4–9. When selecting garlic for planting, it is important to pick large bulbs from which to separate cloves. Large cloves, along with proper spacing in the planting bed, will also improve bulb size. Garlic plants prefer to grow in a soil with a high organic material content, but are capable of growing in a wide range of soil conditions and pH levels.

There are different varieties or subspecies of garlic, most notably hardneck garlic and softneck garlic. The latitude where the garlic is grown affects the choice of type as garlic can be day-length sensitive. Hardneck garlic is generally grown in cooler climates; softneck garlic is generally grown closer to the equator.

Garlic scapes are removed to focus all the garlic's energy into bulb growth. The scapes can be eaten raw or cooked.

PRODUCTION TRENDS

Garlic is grown globally, but China is by far the largest producer of garlic, with around 20 million tonnes (44 billion pounds) grown annually, accounting for over 81% of world output. India (4.6%) and South Korea (1.4%) follow, with Egypt (1.2%) on fourth place and the United States (where garlic is grown in every state except for Alaska) in ninth place (0.8%). This leaves 11% of global garlic production in countries that each produce less than 2% of global output. Much of the garlic production in the United States is centered in Gilroy, California, which calls itself the "garlic capital of the world".

USES

CULINARY USES

Garlic is widely used around the world for its pungent flavor as a seasoning or condiment.

The garlic plant's bulb is the most commonly used part of the plant. With the exception of the single clove types, garlic bulbs are normally divided into numerous fleshy sections called cloves. Garlic cloves are used for consumption (raw or cooked) or for medicinal purposes. They have a characteristic pungent, spicy flavor that mellows and sweetens considerably with cooking.

Other parts of the garlic plant are also edible. The leaves and flowers (bulbils) on the head (spathe) are sometimes eaten. They are milder in flavor than the bulbs, and are most often consumed while immature and still tender. Immature garlic is sometimes pulled, rather like a scallion, and sold as "green garlic". When green garlic is allowed to grow past the "scallion" stage, but not permitted to fully mature, it may produce a garlic "round", a bulb like a boiling onion, but not separated into cloves like a mature bulb. It imparts a garlic flavor and aroma in food, minus the spiciness. Green garlic is often chopped and stir-fried or cooked in soup or hotpot in Southeast Asian (i.e. Vietnamese, Thai, Lao, Cambodian, Singaporean) and Chinese cookery, and is very abundant and low-priced. Additionally, the immature flower stalks (scapes) of the hardneck and elephant types are sometimes marketed for uses similar to asparagus in stir-fries.

Inedible or rarely eaten parts of the garlic plant include the "skin" covering each clove and root cluster. The papery, protective layers of "skin" over various parts of the plant are generally discarded during preparation for most culinary uses, though in Korea immature whole heads are sometimes prepared with the tender skins intact. The root cluster attached to the basal plate of the bulb is the only part not typically considered palatable in any form.

Garlic is a fundamental component in many or most dishes of various regions, including eastern Asia, South Asia, Southeast Asia, the Middle East, northern Africa, southern Europe, and parts of South and Central America. The flavor varies in intensity and aroma with the different cooking methods. It is often paired with onion, tomato, or ginger. The parchment-like skin is much like the skin of an onion, and is typically removed before using in raw or cooked form. An alternative is to cut the top off the bulb, coat the cloves by dribbling olive oil (or other oil-based seasoning) over them, and roast them in an oven. Garlic softens and can be extracted from the cloves by squeezing the (root) end of the bulb, or individually by squeezing one end of the clove. In Korea, heads of garlic are heated over the course of several weeks; the resulting product, called black garlic, is sweet and syrupy, and is now being sold in the United States, United Kingdom and Australia.Garlic may be applied to different kinds of bread, usually in a medium of butter or oil, to create a variety of classic dishes, such as garlic bread, garlic toast, bruschetta, crostini and canapé.

Oils can be flavored with garlic cloves. These infused oils are used to season all categories of vegetables, meats, breads and pasta. Garlic, along with fish sauce, chopped fresh chilis, lime juice, sugar and water, is a basic essential item in dipping fish sauce, a highly used dipping sauce condiment used in Indochina. In East and Southeast Asia, chili oil with garlic is a popular dipping sauce, especially for meat and seafood. Tuong ot toi Viet Nam (Vietnam Chili Garlic Sauce) is a highly popular condiment and dip across North America and Asia.

In some cuisines, the young bulbs are pickled for three to six weeks in a mixture of sugar, salt, and spices. In eastern Europe, the shoots are pickled and eaten as an appetizer. Laba garlic, prepared by soaking garlic in vinegar, is a type of pickled garlic served with dumplings in northern China to celebrate the Chinese New Year.

Lightly smoked garlic is becoming increasingly popular in British and European cuisine. It is particularly prized for stuffing poultry and game, and in soups and stews. In both these cases it is important to utilize the undiscarded skin, as much of the smoke flavor is situated there, rather than in the cloves themselves.

Immature scapes are tender and edible. They are also known as "garlic spears", "stems", or "tops". Scapes generally have a milder taste than the cloves. They are often used in stir frying or braised like asparagus. Garlic leaves are a popular vegetable in many parts of Asia. The leaves are cut, cleaned, and then stir-fried with eggs, meat, or vegetables.

Mixing garlic with egg yolks and olive oil produces aioli. Garlic, oil, and a chunky base produce skordalia. Blending garlic, almond, oil, and soaked bread produces ajoblanco. Tzatziki, yogurt mixed with garlic and salt is a common sauce in Eastern Mediterranean cuisines.

Garlic powder has a different taste from fresh garlic. If used as a substitute for fresh garlic, 1/8 teaspoon of garlic powder is equivalent to one clove of garlic.

STORAGE

Domestically, garlic is stored warm - above 18 °C - and dry to keep it dormant (lest it sprout). It is traditionally hung; softneck varieties are often braided in strands called plaits or grappes. Peeled cloves may be stored in wine or vinegar in the refrigerator. Commercially, garlic is stored at 0 °C, in a dry, low-humidity environment. Garlic will keep longer if the tops remain attached.

Garlic is often kept in oil to produce flavored oil; however, the practice requires measures to be taken to prevent the garlic from spoiling. Untreated garlic kept in oil can support the growth of Clostridium botulinum which causes the deadly botulism illness; refrigeration will not assure the safety of garlic kept in oil. To reduce this risk, the oil should be refrigerated and used within one week. According to wikihow, the garlic immersed in oil should be stored in the freezer and not the fridge. Commercially prepared oils are widely available. Manufacturers add acids or other chemicals to eliminate the risk of botulism in their products. Two outbreaks of botulism related to garlic stored in oil have been reported.

Garlic bulbs should be clean and white with a dried neck and outer skin and quite firm under pressure. They should be discarded if they are soft or spongy or show signs of mold.

HISTORICAL USE

The use of garlic in China dates back to 2000 BC. It was consumed by ancient Greek and Roman soldiers, sailors, and rural classes (Virgil, Ecologues ii. 11), and, according to Pliny the Elder (Natural History xix. 32), by the African peasantry. Galen eulogized it as the "rustic's theriac" (cure-all) (see F. Adams' Paulus Aegineta, p. 99), and Alexander Neckam, a writer of the 12th century (see Wright's edition of his works, p. 473, 1863), discussed it as a palliative for the heat of the sun in field labor. Garlic was placed by the ancient Greeks on the piles of stones at crossroads, as a supper for Hecate (Theophrastus, Characters, The Superstitious Man). According to Pliny, garlic and onions were invoked as deities by the Egyptians at the taking of oaths.

In his Natural History, Pliny gives a list of scenarios in which garlic was considered beneficial (N.H. xx. 23). Dr. T. Sydenham valued it as an application in confluent smallpox, and, says Cullen (Mat. Med. ii. p. 174, 1789), found some dropsies cured by it alone.

Garlic was rare in traditional English cuisine (though it is said to have been grown in England before 1548) and has been a much more common ingredient in Mediterranean Europe.[citation needed] Translations of the c. 1300 Assize of Weights and Measures indicate a passage as dealing with standardized units of garlic production, sale, and taxation - the hundred of 15 ropes of 15 heads each - but the Latin version of the text refers to herring rather than garlic.

Garlic was used as an antiseptic to prevent gangrene during World Wars I and II.

NUTRIENTS

In the typical serving size of 1-3 cloves (3-9 g), garlic provides no significant nutritional value with the content of all essential nutrients below 10% of the Daily Value (DV) (right table). When expressed per 100 grams, garlic contains several nutrients in rich amounts (> 20% DV), including vitamins B6 and C, and the dietary minerals, manganese and phosphorus. Per 100 gram serving, garlic is also a good source (10-19% DV) of certain B vitamins including thiamine (Vitamin B1), and pantothenic acid (Vitamin B5), as well as certain dietary minerals including calcium, iron, and zinc (right table).

RESEARCH

CARDIOVASCULAR

A 2013 meta-analysis concluded that garlic preparations may effectively lower total cholesterol by 11–23 mg/dL and LDL cholesterol by 3–15 mg/dL in adults with high cholesterol if taken for longer than two months. The same analysis found that garlic had a marginally positive effect on HDL cholesterol, no significant effect on blood triglyceride levels, and that garlic preparations were generally well tolerated with very few side effects.

A 2012 Cochrane review of two randomized controlled trials found that the effect of garlic supplementation on blood pressure is unclear and that there is insufficient evidence to determine if garlic lowers cardiovascular death and disease rates in people with hypertension.

As garlic may reduce platelet aggregation, patients taking anticoagulant medication are cautioned about consuming garlic.

CANCER

A 2014 meta-analysis of observational epidemiological studies found that garlic consumption is associated with a lower risk of stomach cancer in the Korean population. Similarly, a 2013 meta-analysis of case-control studies and cohort studies found limited evidence suggesting an association between higher garlic consumption and a lower risk of prostate cancer. However, the association was only significant in the case-control studies and the authors noted there was evidence of publication bias.

COMMON COLD

One news source reported garlic supplements may prevent the common cold, but there is insufficient clinical research to confirm this effect. A 2014 report in the Cochrane Database of Systematic Reviews concluded that "there is insufficient clinical trial evidence regarding the effects of garlic in preventing or treating the common cold. A single trial suggested that garlic may prevent occurrences of the common cold but more studies are needed to validate this finding. Claims of effectiveness appear to rely largely on poor-quality evidence." Another review reached similar conclusions about the lack of high-quality evidence for the idea that garlic prevents or treats the common cold.

OTHER USES

The sticky juice within the bulb cloves is used as an adhesive in mending glass and porcelain. An environmentally benign garlic-derived polysulfide product is approved for use in the European Union (under Annex 1 of 91/414) and the UK as a nematicide and insecticide, including for use for control of cabbage root fly and red mite in poultry.

Garlic along with cinnamon is used as a fish and meat preservative, and displays antimicrobial property at temperatures as high as 120 degree Celsius; the combination can also be used to preserve fried and deep fried foods, and in the future might be used in an inner layer of plastic.

ADVERSE EFFECTS AND TOXICOLOGY

Garlic is known to cause bad breath (halitosis) and body odor, described as a pungent "garlicky" smell to sweat. This is caused by allyl methyl sulfide (AMS). AMS is a volatile liquid which is absorbed into the blood during the metabolism of garlic-derived sulfur compounds; from the blood it travels to the lungs (and from there to the mouth, causing bad breath; see garlic breath) and skin, where it is exuded through skin pores. Washing the skin with soap is only a partial and imperfect solution to the smell. Studies have shown sipping milk at the same time as consuming garlic can significantly neutralize bad breath. Mixing garlic with milk in the mouth before swallowing reduced the odor better than drinking milk afterward. Plain water, mushrooms and basil may also reduce the odor; the mix of fat and water found in milk, however, was the most effective.

The green, dry "folds" in the center of the garlic clove are especially pungent. The sulfur compound allicin, produced by crushing or chewing fresh garlic, produces other sulfur compounds: ajoene, allyl polysulfides, and vinyldithiins. Aged garlic lacks allicin, but may have some activity due to the presence of S-allylcysteine.

Some people suffer from allergies to garlic and other species of Allium. Symptoms can include irritable bowel, diarrhea, mouth and throat ulcerations, nausea, breathing difficulties, and, in rare cases, anaphylaxis. Garlic-sensitive patients show positive tests to diallyl disulfide, allylpropyldisulfide, allylmercaptan and allicin, all of which are present in garlic. People who suffer from garlic allergies are often sensitive to many other plants, including onions, chives, leeks, shallots, garden lilies, ginger, and bananas.

Several reports of serious burns resulting from garlic being applied topically for various purposes, including naturopathic uses and acne treatment, indicate care must be taken for these uses, usually testing a small area of skin using a very low concentration of garlic. On the basis of numerous reports of such burns, including burns to children, topical use of raw garlic, as well as insertion of raw garlic into body cavities, is discouraged. In particular, topical application of raw garlic to young children is not advisable. The side effects of long-term garlic supplementation are largely unknown, and no FDA-approved study has been performed. Possible side effects include gastrointestinal discomfort, sweating, dizziness, allergic reactions, bleeding, and menstrual irregularities.

Some breastfeeding mothers have found, after consuming garlic, that their babies can be slow to feed, and have noted a garlic odor coming from them.

If higher than recommended doses of garlic are taken with anticoagulant medications, this can lead to a higher risk of bleeding. Garlic may interact with warfarin, antiplatelets, saquinavir, antihypertensives, calcium channel blockers, quinolone family of antibiotics such as ciprofloxacin, and hypoglycemic drugs, as well as other medications. Alliums might be toxic to cats or dogs.

SPIRITUAL AND RELIGIOUS USES

Garlic has been regarded as a force for both good and evil. In Europe, many cultures have used garlic for protection or white magic, perhaps owing to its reputation as a potent preventative medicine. Central European folk beliefs considered garlic a powerful ward against demons, werewolves, and vampires. To ward off vampires, garlic could be worn, hung in windows, or rubbed on chimneys and keyholes.

In Iranian countries which celebrate Nowruz (Persian calendar New Year) such as Iran, the Caucasus countries, Afghanistan, and Central Asian countries such as Tajikistan and Uzbekistan, garlic is one of the items in a Seven-Seen table, a traditional New Year's display.

In Islam, it is generally recommended not to eat raw garlic prior to going to the mosque, since the odor could distract other Muslims during their prayer. Muhammad himself disliked eating garlic.

In both Hinduism and Jainism, garlic is thought to stimulate and warm the body and to increase one's desires. Some devout Hindus generally avoid using garlic and the related onion in the preparation of foods, while less devout followers may only observe this for religious festivities and events. Followers of the Jain religion avoid eating garlic and onion on a daily basis.

In some Buddhist traditions, garlic – along with the other five "pungent spices" – is understood to stimulate sexual and aggressive drives to the detriment of meditation practice. In Mahayana Buddhism, monks and nuns are not allowed to consume garlic or other pungent spices such as chili, which are deemed as being "earthly pleasures" and are viewed as promoting aggression due to their spiciness and pungency.

PROPERTIES

Fresh or crushed garlic yields the sulfur-containing compounds alliin, ajoene, diallyl polysulfides, vinyldithiins, S-allylcysteine, and enzymes, saponins, flavonoids, and Maillard reaction products, which are not sulfur-containing compounds.

The composition of the bulbs is approximately 84.09% water, 13.38% organic matter, and 1.53% inorganic matter, while the leaves are 87.14% water, 11.27% organic matter, and 1.59% inorganic matter.

The phytochemicals responsible for the sharp flavor of garlic are produced when the plant's cells are damaged. When a cell is broken by chopping, chewing, or crushing, enzymes stored in cell vacuoles trigger the breakdown of several sulfur-containing compounds stored in the cell fluids (cytosol). The resultant compounds are responsible for the sharp or hot taste and strong smell of garlic. Some of the compounds are unstable and continue to react over time. Among the members of the onion family, garlic has by far the highest concentrations of initial reaction products, making garlic much more potent than onion, shallot, or leeks. Although many humans enjoy the taste of garlic, these compounds are believed to have evolved as a defensive mechanism, deterring animals such as birds, insects, and worms from eating the plant. Because of this, people throughout history have used garlic to keep away insects such as mosquitoes and slugs.

A large number of sulfur compounds contribute to the smell and taste of garlic. Allicin has been found to be the compound most responsible for the "hot" sensation of raw garlic. This chemical opens thermo-transient receptor potential channels that are responsible for the burning sense of heat in foods. The process of cooking garlic removes allicin, thus mellowing its spiciness. Allicin, along with its decomposition products diallyl disulfide and diallyl trisulfide, are major contributors to the characteristic odor of garlic, with other allicin-derived compounds, such as vinyldithiins and ajoene. Because of its strong odor, garlic is sometimes called the "stinking rose". When eaten in quantity, garlic may be strongly evident in the diner's sweat and garlic breath the following day. This is because garlic's strong-smelling sulfur compounds are metabolized, forming allyl methyl sulfide. Allyl methyl sulfide (AMS) cannot be digested and is passed into the blood. It is carried to the lungs and the skin, where it is excreted. Since digestion takes several hours, and release of AMS several hours more, the effect of eating garlic may be present for a long time.

The well-known phenomenon of "garlic breath" is allegedly alleviated by eating fresh parsley. The herb is, therefore, included in many garlic recipes, such as pistou, persillade, and the garlic butter spread used in garlic bread.

Because of the AMS in the bloodstream, it is believed by some to act as a mosquito repellent, but no clinically reported evidence suggests it is actually effective.

Abundant sulfur compounds in garlic are also responsible for turning garlic green or blue during pickling and cooking. Under these conditions (i.e. acidity, heat) the sulfur-containing compound alliinase react with common amino acids to make pyrroles, clusters of carbon-nitrogen rings. These rings can be linked together into polypyrrole molecules. Ring structures absorb particular wavelengths of light and thus appear colored. The two-pyrrole molecule looks red, the three-pyrrole molecule looks blue and the four-pyrrole molecule looks green (like chlorophyll, a tetrapyrrole). Like chlorophyll, the pyrrole pigments are safe to eat.

WIKIPEDIA

Bear Lake by CameliaTWU

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First mentioned in a 1597 document but recorded as a resort in 1850, Sovata is located at an altitute of 1,600 ft. in the forested region of Transylvania, Romania. Sovata features the heliothermal and salty Ursu (Bear) lake – unique in Europe, located in a depression of a salt mountain. The place where the lake is now was originally a pasture. The mineral waters here are highly prescribed in gynecological and sterility afflictions, rheumatic pains, peripheral nervous system and post-accidental motor diseases. Sovata has other salty lakes, such as Alunis, Black, Red and Green Lakes.