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Original Caption: Haze in the Santa Monica Mountains near the west edge of Los Angeles County, California. The mountains contain the last semi-wilderness in the metropolitan area. Some 84 percent of the state's residents live within 30 miles of the coast, and this concentration has resulted in increased land use pressures several commissions have been authorized by the legislature to restrict coastal development and recommend guidelines for the future, May 1975

  

U.S. National Archives’ Local Identifier: 412-DA-15106

 

Photographer: O'Rear, Charles, 1941-

  

Subjects:

California

Environmental Protection Agency

Project DOCUMERICA

  

Persistent URL: research.archives.gov/description/557558

 

Repository: Still Picture Records Section, Special Media Archives Services Division (NWCS-S), National Archives at College Park, 8601 Adelphi Road, College Park, MD, 20740-6001.

 

For information about ordering reproductions of photographs held by the Still Picture Unit, visit: www.archives.gov/research/order/still-pictures.html

 

Reproductions may be ordered via an independent vendor. NARA maintains a list of vendors at www.archives.gov/research/order/vendors-photos-maps-dc.html

 

Access Restrictions: Unrestricted

Use Restrictions: Unrestricted

Persistent URL: digital.lib.muohio.edu/u?/tradecards,4730

 

Subject (TGM): Flowers; Roses; Furniture; Furniture industry; Furniture stores;

Margolies, John,, photographer.

 

City Building, brick columns, Locus Street, Harrisburg, Illinois

 

1993.

 

1 photograph : color transparency ; 35 mm (slide format).

 

Notes:

Title, date and keywords based on information provided by the photographer.

Margolies categories: Municipal town/city halls; Main Street.

Purchase; John Margolies 2015 (DLC/PP-2015:142).

Credit line: John Margolies Roadside America photograph archive (1972-2008), Library of Congress, Prints and Photographs Division.

Please use digital image: original slide is kept in cold storage for preservation.

Forms part of: John Margolies Roadside America photograph archive (1972-2008).

 

Subjects:

Commercial facilities--1990-2000.

United States--Illinois--Harrisburg.

 

Format: Slides--1990-2000.--Color

 

Rights Info: No known restrictions on publication. For more information, see "John Margolies Roadside America Photograph Archive - Rights and Restrictions Information" www.loc.gov/rr/print/res/723_marg.html

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

Part Of: Margolies, John John Margolies Roadside America photograph archive (DLC) 2010650110

 

General information about the John Margolies Roadside America photograph archive is available at hdl.loc.gov/loc.pnp/pp.mrg

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/mrg.03849

 

Call Number: LC-MA05- 3849

 

GenPersistent URL: floridamemory.com/items/show/138284

 

Local call number: N028606

 

Title: Tin can tourist trailer show - Tampa

 

Date: 1949

Physical descrip: photoprint - b&w - 5 x 4 in.

 

Series Title: Newberry Collection

 

Repository: State Library and Archives of Florida

500 S. Bronough St., Tallahassee, FL, 32399-0250 USA, Contact: 850.245.6700, Archives@dos.myflorida.comeral Collection

Persistent URL: floridamemory.com/items/show/30091

 

Local call number: RC06912

 

Title: Piggly Wiggly grocery store: Coral Gables, Florida

 

Date: July 23, 1924

 

Physical descrip: 1 photoprint - b&w - 8 x 10 in.

 

Series Title: Reference Collection

 

Repository: State Library and Archives of Florida, 500 S. Bronough St., Tallahassee, FL 32399-0250 USA. Contact: 850.245.6700. Archives@dos.state.fl.us

  

Over 36 hours, 6 inches of snow melted under persistent rain- and this is the result. Armleder park flooded by the little Miami river.

Under the Norfolk pine next to the entrance of the display gallery of the Belle Isle Conservatory, poinsettias from the Christmas display thrive.

Persistent URL: digital.lib.muohio.edu/u?/tradecards,3038

 

Subject (TGM): Cats; Animals in human situations; Marching bands; Drums; Flutes; Household soap; Cosmetics & soap; Chemical industry; Grocery stores;

Persistente es la niebla

no deja ver los caminos

ni las carreteras se ven

más, ahí adelante están

los peligros de la vida .

 

Unas veces naturales,

las más, el hombre las hace ,

por no saber solucionar

la salida pertinente

para salir del peligro.

Local call number: DM0271

 

Title: Fort Jefferson: Dry Tortugas, Florida

 

Date: August 1985

 

Physical descrip: 1 slide - col.

 

Series Title: Dale M. McDonald Collection

 

Repository: State Library and Archives of Florida, 500 S. Bronough St., Tallahassee, FL 32399-0250 USA. Contact: 850.245.6700. Archives@dos.state.fl.us

 

Persistent URL: www.floridamemory.com/items/show/97622

 

“ A corporeal phenomenon, a feeling, a perception, a mental formation, a consciousness, which is permanent and persistent, eternal and not subject to change, such a thing the wise men in this world do not recognize; and I also say that there is no such thing.”

(Siddhārtha Gautama (Buddha Sakyamuni) - founder of Buddhism, 563 - 483 B.C)

 

This man was washing near Assi Ghat, in Varanasi (Benaras).

The same day it was written in the newspapers that from now it was forbidden to use soap along the Ganges in order to lower polution's intensity.

It might take a long time until people start to change their behavior there...

View On Black

 

Join the photographer at www.facebook.com/laurent.goldstein.photography

 

© All photographs are copyrighted and all rights reserved.

Please do not use any photographs without permission (even for private use).

The use of any work without consent of the artist is PROHIBITED and will lead automatically to consequences.

 

Persistent URL: digital.lib.muohio.edu/u?/tradecards,2441

 

Subject (TGM): Frogs; Toads; Amphibians; Fishing; Household soap; Cosmetics & soap; Chemical industry;

Rothstein, Arthur,, 1915-1985,, photographer.

 

Instructor explaining the operation of a parachute to student pilots, Meacham Field, Fort Worth, Tex.

 

1942 Jan.

 

1 slide : color.

 

Notes:

Title from FSA or OWI agency caption.

Transfer from U.S. Office of War Information, 1944.

 

Subjects:

Flight training

Parachuting

United States--Texas--Fort Worth

 

Format: Slides--Color

 

Rights Info: No known restrictions on publication.

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

Part Of: Farm Security Administration - Office of War Information Collection 11671-20 (DLC) 93845501

 

General information about the FSA/OWI Color Photographs is available at hdl.loc.gov/loc.pnp/pp.fsac

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/fsac.1a34243

 

Call Number: LC-USF35-280

  

It's not yet 1:30 PM and this hawk has already visited our yard 3 times today in hopes of catching lunch.

Persistent URL: digital.lib.muohio.edu/u?/tradecards,1853

 

Subject (TGM): Myths; Mermaids; Bodies of water; Lakes & ponds; Hairdressing; Hair preparations; Shipwrecks; Patent medicines; Cosmetics & soap; Sailing ships; Ship accidents; Ships; Hair; Grooming; Hairstyles;

Palmer, Alfred T.,, photographer.

 

Formerly an aircraft dock, this huge building -- thought to be the largest in the world with no interior supports -- is now the scene of many busy shops turning out aircraft sub-assembly parts, Goodyear Aircraft Corp., Akron, Ohio. Either new housing close to the plant or vastly improved public transportation will eventually have to be supplied, for the tires on the cars of the workers, and perhaps even the cars themselves, will in many instances give in before the end of the present emergency

 

1941 Dec.

 

1 transparency : color.

 

Notes:

Title from FSA or OWI agency caption.

Transfer from U.S. Office of War Information, 1944.

 

Subjects:

Goodyear Aircraft Corp.

World War, 1939-1945

Airplane industry

Hangars

United States--Ohio--Akron

 

Format: Transparencies--Color

 

Rights Info: No known restrictions on publication.

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

Part Of: Farm Security Administration - Office of War Information Collection 12002-28 (DLC) 93845501

 

General information about the FSA/OWI Color Photographs is available at hdl.loc.gov/loc.pnp/pp.fsac

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/fsac.1a35066

 

Call Number: LC-USW36-195

  

Original Caption: Lerone Bennett, Well Known Black Writer Who Is Senior Editor At Ebony Magazine, In His Office At Johnson Publishing Company In Chicago. The Firm Also Publishes Jet, Black World, Black Stars And Ebony Jr. As The Top Black Owned Business In Chicago, The Firm Recorded 1972 Sales Of $23.1 Million. Chicago Is Believed To Be The Black Business Capital Of The Country With 14 Of The Top 100 Black Owned Businesses Compared To 13 For New York City, 10/1973

 

U.S. National Archives’ Local Identifier: 412-DA-13798

 

Photographer: White, John H, 1945-

 

Subjects:

African-American

Chicago (Cook county, Illinois, United States)

Environmental Protection Agency

Project DOCUMERICA

 

Persistent URL: arcweb.archives.gov/arc/action/ExternalIdSearch?id=556250

 

Repository: Still Picture Records Section, Special Media Archives Services Division (NWCS-S), National Archives at College Park, 8601 Adelphi Road, College Park, MD, 20740-6001.

 

For information about ordering reproductions of photographs held by the Still Picture Unit, visit: www.archives.gov/research/order/still-pictures.html

 

Reproductions may be ordered via an independent vendor. NARA maintains a list of vendors at www.archives.gov/research/order/vendors-photos-maps-dc.html

 

Access Restrictions: Unrestricted

Use Restrictions: Unrestricted

Persistent URL: digital.lib.muohio.edu/u?/tradecards,3522

 

Subject (TGM): Flowers; Bouquets; Perfumes; Dressing & grooming equipment; Hygiene;

Persistent URL: floridamemory.com/items/show/8869

  

Local call number: PR10428

  

Title: Underwater photography at the springs

  

Date: ca. 19--

  

Physical descrip: 1 photonegative - b&w - 3 x 5 in.

  

Series Title: Print Collections

  

Repository: State Library and Archives of Florida

500 S. Bronough St., Tallahassee, FL, 32399-0250 USA, Contact: 850.245.6700, Archives@dos.myflorida.com

Persistent URL: floridamemory.com/items/show/11405

  

Local call number: PR10455

  

Title: F.S.C.W. Tarpon Club - Wakulla Springs

  

Date: ca. 1949

  

Physical descrip: 1 photonegative - b&w - 3 x 5 in.

  

Series Title: Print Collections

  

Repository: State Library and Archives of Florida

500 S. Bronough St., Tallahassee, FL, 32399-0250 USA, Contact: 850.245.6700, Archives@dos.myflorida.com

[Smeerenburg at Danskerne, Spitzbergen, Norway]

 

[between ca. 1890 and ca. 1900].

 

1 photomechanical print : photochrom, color.

 

Notes:

Title from the Detroit Publishing Co., Catalogue J--foreign section. Detroit, Mich. : Detroit Publishing Company, 1905.

Print no. 7190.

Forms part of: Landscape and marine views of Norway in the Photochrom print collection.

 

Subjects:

Norway--Spitsbergen Island.

 

Format: Photochrom prints--Color--1890-1900.

 

Rights Info: No known restrictions on publication.

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

Part Of: Landscape and marine views of Norway (DLC) 2001699563

 

More information about the Photochrom Print Collection is available at hdl.loc.gov/loc.pnp/pp.pgz

 

Persistent URL: hdl.loc.gov/loc.pnp/ppmsc.06227

 

Call Number: LOT 13432, no. 125 [item]

  

Persistent vegetative state

SpecialtyNeurology

A persistent vegetative state (PVS) is a disorder of consciousness in which patients with severe brain damage are in a state of partial arousal rather than true awareness. After four weeks in a vegetative state (VS), the patient is classified as in a persistent vegetative state. This diagnosis is classified as a permanent vegetative state some months (three in the US and six in the UK) after a non-traumatic brain injury or one year after a traumatic injury. Today, doctors and neuroscientists prefer to call the state of consciousness a syndrome,[1] primarily because of ethical questions about whether a patient can be called "vegetative" or not.[2]

  

Contents

1Definition

1.1Medical definition

1.2Lack of legal clarity

1.3Vegetative state

1.4Persistent vegetative state

2Signs and symptoms

2.1Recovery

3Causes

4Diagnosis

4.1Diagnostic experiments

4.2Misdiagnoses

5Treatment

5.1Zolpidem

6Epidemiology

7History

8Society and culture

8.1Ethics and policy

8.2Notable cases

9See also

10References

11External links

Definition[edit]

There are several definitions that vary by technical versus layman's usage. There are different legal implications in different countries.

 

Medical definition[edit]

A wakeful unconscious state that lasts longer than a few weeks is referred to as a persistent (or 'continuing') vegetative state.[3]

 

Lack of legal clarity[edit]

Unlike brain death, permanent vegetative state (PVS) is recognized by statute law as death in very few legal systems. In the US, courts have required petitions before termination of life support that demonstrate that any recovery of cognitive functions above a vegetative state is assessed as impossible by authoritative medical opinion.[4] In England and Wales the legal precedent for withdrawal of clinically assisted nutrition and hydration in cases of patients in a PVS was set in 1993 in the case of Tony Bland, who sustained catastrophic anoxic brain injury in the 1989 Hillsborough disaster.[3] An application to the Court of Protection is no longer required before nutrition and hydration can be withdrawn or withheld from PVS (or 'minimally conscious' – MCS) patients.[5]

 

This legal grey area has led to vocal advocates that those in PVS should be allowed to die. Others are equally determined that, if recovery is at all possible, care should continue. The existence of a small number of diagnosed PVS cases that have eventually resulted in improvement makes defining recovery as "impossible" particularly difficult in a legal sense.[6] This legal and ethical issue raises questions about autonomy, quality of life, appropriate use of resources, the wishes of family members, and professional responsibilities.

 

Vegetative state[edit]

The vegetative state is a chronic or long-term condition. This condition differs from a coma: a coma is a state that lacks both awareness and wakefulness. Patients in a vegetative state may have awoken from a coma, but still have not regained awareness. In the vegetative state patients can open their eyelids occasionally and demonstrate sleep-wake cycles, but completely lack cognitive function. The vegetative state is also called a "coma vigil". The chances of regaining awareness diminish considerably as the time spent in the vegetative state increases.[7]

 

Persistent vegetative state[edit]

Persistent vegetative state is the standard usage (except in the UK) for a medical diagnosis, made after numerous neurological and other tests, that due to extensive and irreversible brain damage a patient is highly unlikely ever to achieve higher functions above a vegetative state. This diagnosis does not mean that a doctor has diagnosed improvement as impossible, but does open the possibility, in the US, for a judicial request to end life support.[6] Informal guidelines hold that this diagnosis can be made after four weeks in a vegetative state. US caselaw has shown that successful petitions for termination have been made after a diagnosis of a persistent vegetative state, although in some cases, such as that of Terri Schiavo, such rulings have generated widespread controversy.

 

In the UK, the term is discouraged in favor of two more precisely defined terms that have been strongly recommended by the Royal College of Physicians (RCP). These guidelines recommend using a continuous vegetative state for patients in a vegetative state for more than four weeks. A medical determination of a permanent vegetative state can be made if, after exhaustive testing and a customary 12 months of observation,[8] a medical diagnosis is made that it is impossible by any informed medical expectations that the mental condition will ever improve.[9] Hence, a "continuous vegetative state" in the UK may remain the diagnosis in cases that would be called "persistent" in the US or elsewhere.

 

While the actual testing criteria for a diagnosis of "permanent" in the UK are quite similar to the criteria for a diagnosis of "persistent" in the US, the semantic difference imparts in the UK a legal presumption that is commonly used in court applications for ending life support.[8] The UK diagnosis is generally only made after 12 months of observing a static vegetative state. A diagnosis of a persistent vegetative state in the US usually still requires a petitioner to prove in court that recovery is impossible by informed medical opinion, while in the UK the "permanent" diagnosis already gives the petitioner this presumption and may make the legal process less time-consuming.[6]

 

In common usage, the "permanent" and "persistent" definitions are sometimes conflated and used interchangeably. However, the acronym "PVS" is intended[by whom?] to define a "persistent vegetative state", without necessarily the connotations of permanence,[citation needed] and is used as such throughout this article. Bryan Jennett, who originally coined the term "persistent vegetative state", has now recommended using the UK division between continuous and permanent in his book The Vegetative State, arguing that "the 'persistent' component of this term ... may seem to suggest irreversibility".[10]

 

The Australian National Health and Medical Research Council has suggested "post coma unresponsiveness" as an alternative term for "vegetative state" in general.[11]

 

Signs and symptoms[edit]

Most PVS patients are unresponsive to external stimuli and their conditions are associated with different levels of consciousness. Some level of consciousness means a person can still respond, in varying degrees, to stimulation. A person in a coma, however, cannot. In addition, PVS patients often open their eyes in response to feeding, which has to be done by others; they are capable of swallowing, whereas patients in a coma subsist with their eyes closed (Emmett, 1989).

 

Cerebral cortical function (e.g. communication, thinking, purposeful movement, etc) is lost while brainstem functions (e.g. breathing, maintaining circulation and hemodynamic stability, etc) are preserved. Non-cognitive upper brainstem functions such as eye-opening, occasional vocalizations (e.g. crying, laughing), maintaining normal sleep patterns, and spontaneous non-purposeful movements often remain intact.

 

PVS patients' eyes might be in a relatively fixed position, or track moving objects, or move in a disconjugate (i.e., completely unsynchronized) manner. They may experience sleep-wake cycles, or be in a state of chronic wakefulness. They may exhibit some behaviors that can be construed as arising from partial consciousness, such as grinding their teeth, swallowing, smiling, shedding tears, grunting, moaning, or screaming without any apparent external stimulus.

 

Individuals in PVS are seldom on any life-sustaining equipment other than a feeding tube because the brainstem, the center of vegetative functions (such as heart rate and rhythm, respiration, and gastrointestinal activity) is relatively intact (Emmett, 1989).

 

Recovery[edit]

Many people emerge spontaneously from a vegetative state within a few weeks.[10] The chances of recovery depend on the extent of injury to the brain and the patient's age – younger patients having a better chance of recovery than older patients. A 1994 report found that of those who were in a vegetative state a month after a trauma, 54% had regained consciousness by a year after the trauma, whereas 28% had died and 18% were still in the vegetative state. But for non-traumatic injuries such as strokes, only 14% had recovered consciousness at one year, 47% had died, and 39% were still vegetative. Patients who were vegetative six months after the initial event were much less likely to have recovered consciousness a year after the event than in the case of those who were simply reported vegetative at one month.[12] A New Scientist article from 2000 gives a pair of graphs[13] showing changes of patient status during the first 12 months after head injury and after incidents depriving the brain of oxygen.[14] After a year, the chances that a PVS patient will regain consciousness are very low[15] and most patients who do recover consciousness experience significant disability. The longer a patient is in a PVS, the more severe the resulting disabilities are likely to be. Rehabilitation can contribute to recovery, but many patients never progress to the point of being able to take care of themselves.

 

There are two dimensions of recovery from a persistent vegetative state: recovery of consciousness and recovery of function. Recovery of consciousness can be verified by reliable evidence of awareness of self and the environment, consistent voluntary behavioral responses to visual and auditory stimuli, and interaction with others. Recovery of function is characterized by communication, the ability to learn and to perform adaptive tasks, mobility, self-care, and participation in recreational or vocational activities. Recovery of consciousness may occur without functional recovery, but functional recovery cannot occur without recovery of consciousness (Ashwal, 1994).

 

Causes[edit]

There are three main causes of PVS (persistent vegetative state):

 

Acute traumatic brain injury

Non-traumatic: neurodegenerative disorder or metabolic disorder of the brain

Severe congenital abnormality of the central nervous system

Medical books (such as Lippincott, Williams, and Wilkins. (2007). In A Page: Pediatric Signs and Symptoms) describe several potential causes of PVS, which are as follows:

 

Bacterial, viral, or fungal infection, including meningitis

Increased intracranial pressure, such as a tumor or abscess

Vascular pressure which causes intracranial hemorrhaging or stroke

Hypoxic ischemic injury (hypotension, cardiac arrest, arrhythmia, near-drowning)

Toxins such as uremia, ethanol, atropine, opiates, lead, colloidal silver[16]

Trauma: Concussion, contusion

Seizure, both nonconvulsive status epilepticus and postconvulsive state (postictal state)

Electrolyte imbalance, which involves hyponatremia, hypernatremia, hypomagnesemia, hypoglycemia, hyperglycemia, hypercalcemia, and hypocalcemia

Postinfectious: Acute disseminated encephalomyelitis (ADEM)

Endocrine disorders such as adrenal insufficiency and thyroid disorders

Degenerative and metabolic diseases including urea cycle disorders, Reye syndrome, and mitochondrial disease

Systemic infection and sepsis

Hepatic encephalopathy

In addition, these authors claim that doctors sometimes use the mnemonic device AEIOU-TIPS to recall portions of the differential diagnosis: Alcohol ingestion and acidosis, Epilepsy and encephalopathy, Infection, Opiates, Uremia, Trauma, Insulin overdose or inflammatory disorders, Poisoning and psychogenic causes, and Shock.

 

Diagnosis[edit]

Despite converging agreement about the definition of persistent vegetative state, recent reports have raised concerns about the accuracy of diagnosis in some patients, and the extent to which, in a selection of cases, residual cognitive functions may remain undetected and patients are diagnosed as being in a persistent vegetative state. Objective assessment of residual cognitive function can be extremely difficult as motor responses may be minimal, inconsistent, and difficult to document in many patients, or may be undetectable in others because no cognitive output is possible (Owen et al., 2002). In recent years, a number of studies have demonstrated an important role for functional neuroimaging in the identification of residual cognitive function in persistent vegetative state; this technology is providing new insights into cerebral activity in patients with severe brain damage. Such studies, when successful, may be particularly useful where there is concern about the accuracy of the diagnosis and the possibility that residual cognitive function has remained undetected.

 

Diagnostic experiments[edit]

Researchers have begun to use functional neuroimaging studies to study implicit cognitive processing in patients with a clinical diagnosis of persistent vegetative state. Activations in response to sensory stimuli with positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electrophysiological methods can provide information on the presence, degree, and location of any residual brain function. However, use of these techniques in people with severe brain damage is methodologically, clinically, and theoretically complex and needs careful quantitative analysis and interpretation.

 

For example, PET studies have shown the identification of residual cognitive function in persistent vegetative state. That is, an external stimulation, such as a painful stimulus, still activates "primary" sensory cortices in these patients but these areas are functionally disconnected from "higher order" associative areas needed for awareness. These results show that parts of the cortex are indeed still functioning in "vegetative" patients (Matsuda et al., 2003).

 

In addition, other PET studies have revealed preserved and consistent responses in predicted regions of auditory cortex in response to intelligible speech stimuli. Moreover, a preliminary fMRI examination revealed partially intact responses to semantically ambiguous stimuli, which are known to tap higher aspects of speech comprehension (Boly, 2004).

 

Furthermore, several studies have used PET to assess the central processing of noxious somatosensory stimuli in patients in PVS. Noxious somatosensory stimulation activated midbrain, contralateral thalamus, and primary somatosensory cortex in each and every PVS patient, even in the absence of detectable cortical evoked potentials. In conclusion, somatosensory stimulation of PVS patients, at intensities that elicited pain in controls, resulted in increased neuronal activity in primary somatosensory cortex, even if resting brain metabolism was severely impaired. However, this activation of primary cortex seems to be isolated and dissociated from higher-order associative cortices (Laureys et al., 2002).

 

Also, there is evidence of partially functional cerebral regions in catastrophically injured brains. To study five patients in PVS with different behavioral features, researchers employed PET, MRI and magnetoencephalographic (MEG) responses to sensory stimulation. In three of the five patients, co-registered PET/MRI correlate areas of relatively preserved brain metabolism with isolated fragments of behavior. Two patients had suffered anoxic injuries and demonstrated marked decreases in overall cerebral metabolism to 30–40% of normal. Two other patients with non-anoxic, multifocal brain injuries demonstrated several isolated brain regions with higher metabolic rates, that ranged up to 50–80% of normal. Nevertheless, their global metabolic rates remained <50% of normal. MEG recordings from three PVS patients provide clear evidence for the absence, abnormality or reduction of evoked responses. Despite major abnormalities, however, these data also provide evidence for localized residual activity at the cortical level. Each patient partially preserved restricted sensory representations, as evidenced by slow evoked magnetic fields and gamma band activity. In two patients, these activations correlate with isolated behavioral patterns and metabolic activity. Remaining active regions identified in the three PVS patients with behavioral fragments appear to consist of segregated corticothalamic networks that retain connectivity and partial functional integrity. A single patient who suffered severe injury to the tegmental mesencephalon and paramedian thalamus showed widely preserved cortical metabolism, and a global average metabolic rate of 65% of normal. The relatively high preservation of cortical metabolism in this patient defines the first functional correlate of clinical–pathological reports associating permanent unconsciousness with structural damage to these regions. The specific patterns of preserved metabolic activity identified in these patients reflect novel evidence of the modular nature of individual functional networks that underlie conscious brain function. The variations in cerebral metabolism in chronic PVS patients indicate that some cerebral regions can retain partial function in catastrophically injured brains (Schiff et al., 2002).

 

Misdiagnoses[edit]

Statistical PVS misdiagnosis is common. An example study with 40 patients in the United Kingdom reported 43% of their patients classified as PVS were believed so and another 33% had recovered whilst the study was underway.[17] Some PVS cases may actually be a misdiagnosis of patients being in an undiagnosed minimally conscious state.[18] Since the exact diagnostic criteria of the minimally conscious state were only formulated in 2002, there may be chronic patients diagnosed as PVS before the secondary notion of the minimally conscious state became known.

 

Whether or not there is any conscious awareness with a patient's vegetative state is a prominent issue. Three completely different aspects of this should be distinguished. First, some patients can be conscious simply because they are misdiagnosed (see above). In fact, they are not in vegetative states. Second, sometimes a patient was correctly diagnosed but is then examined during the early stages of recovery. Third, perhaps some day the notion itself of vegetative states will change so to include elements of conscious awareness. Inability to disentangle these three example cases causes confusion. An example of such confusion is the response to a recent experiment using functional magnetic resonance imaging which revealed that a woman diagnosed with PVS was able to activate predictable portions of her brain in response to the tester's requests that she imagine herself playing tennis or moving from room to room in her house. The brain activity in response to these instructions was indistinguishable from those of healthy patients.[19][20][21]

 

In 2010, Martin Monti and fellow researchers, working at the MRC Cognition and Brain Sciences Unit at the University of Cambridge, reported in an article in the New England Journal of Medicine[22] that some patients in persistent vegetative states responded to verbal instructions by displaying different patterns of brain activity on fMRI scans. Five out of a total of 54 diagnosed patients were apparently able to respond when instructed to think about one of two different physical activities. One of these five was also able to "answer" yes or no questions, again by imagining one of these two activities.[23] It is unclear, however, whether the fact that portions of the patients' brains light up on fMRI could help these patients assume their own medical decision making.[23]

 

In November 2011, a publication in The Lancet presented bedside EEG apparatus and indicated that its signal could be used to detect awareness in three of 16 patients diagnosed in the vegetative state.[24]

 

Treatment[edit]

Currently no treatment for vegetative state exists that would satisfy the efficacy criteria of evidence-based medicine. Several methods have been proposed which can roughly be subdivided into four categories: pharmacological methods, surgery, physical therapy, and various stimulation techniques. Pharmacological therapy mainly uses activating substances such as tricyclic antidepressants or methylphenidate. Mixed results have been reported using dopaminergic drugs such as amantadine and bromocriptine and stimulants such as dextroamphetamine.[25] Surgical methods such as deep brain stimulation are used less frequently due to the invasiveness of the procedures. Stimulation techniques include sensory stimulation, sensory regulation, music and musicokinetic therapy, social-tactile interaction, and cortical stimulation.[26]

 

Zolpidem[edit]

There is limited evidence that the hypnotic drug zolpidem has an effect.[27] The results of the few scientific studies that have been published so far on the effectiveness of zolpidem have been contradictory.[28][29]

 

Epidemiology[edit]

In the United States, it is estimated that there may be between 15,000 and 40,000 patients who are in a persistent vegetative state, but due to poor nursing home records exact figures are hard to determine.[30]

 

History[edit]

The syndrome was first described in 1940 by Ernst Kretschmer who called it apallic syndrome.[31] The term persistent vegetative state was coined in 1972 by Scottish spinal surgeon Bryan Jennett and American neurologist Fred Plum to describe a syndrome that seemed to have been made possible by medicine's increased capacities to keep patients' bodies alive.[10][32]

 

Society and culture[edit]

Ethics and policy[edit]

An ongoing debate exists as to how much care, if any, patients in a persistent vegetative state should receive in health systems plagued by limited resources. In a case before the New Jersey Superior Court, Betancourt v. Trinitas Hospital, a community hospital sought a ruling that dialysis and CPR for such a patient constitutes futile care. An American bioethicist, Jacob M. Appel, argued that any money spent treating PVS patients would be better spent on other patients with a higher likelihood of recovery.[33] The patient died naturally prior to a decision in the case, resulting in the court finding the issue moot.

 

In 2010, British and Belgian researchers reported in an article in the New England Journal of Medicine that some patients in persistent vegetative states actually had enough consciousness to "answer" yes or no questions on fMRI scans.[34] However, it is unclear whether the fact that portions of the patients' brains light up on fMRI will help these patient assume their own medical decision making.[34] Professor Geraint Rees, Director of the Institute of Cognitive Neuroscience at University College London, responded to the study by observing that, "As a clinician, it would be important to satisfy oneself that the individual that you are communicating with is competent to make those decisions. At the moment it is premature to conclude that the individual able to answer 5 out of 6 yes/no questions is fully conscious like you or I."[34] In contrast, Jacob M. Appel of the Mount Sinai Hospital told the Telegraph that this development could be a welcome step toward clarifying the wishes of such patients. Appel stated: "I see no reason why, if we are truly convinced such patients are communicating, society should not honour their wishes. In fact, as a physician, I think a compelling case can be made that doctors have an ethical obligation to assist such patients by removing treatment. I suspect that, if such individuals are indeed trapped in their bodies, they may be living in great torment and will request to have their care terminated or even active euthanasia."[34]

 

Notable cases[edit]

Tony Bland – first patient in English legal history to be allowed to die

Paul Brophy – first American to die after court-authorization

Sunny von Bülow – lived almost 28 years in a persistent vegetative state until her death

Gustavo Cerati – Argentine singer-songwriter, composer and producer who died after four years in a coma

Prichard Colón – Puerto Rican former professional boxer and gold medal winner who spent years in a vegetative state after a bout

Nancy Cruzan – American woman involved in a landmark United States Supreme Court case

Gary Dockery – American police officer who entered, emerged and later reentered a persistent vegetative state

Eluana Englaro – Italian woman from Lecco whose life was ended after a legal case after spending 17 years in a vegetative state

Elaine Esposito – American child who was a previous record holder for having spent 37 years in a coma

Lia Lee – Hmong child who spent 26 years in a vegetative state and was the subject of a 1997 book by Anne Fadiman

Haleigh Poutre

Karen Ann Quinlan

Terri Schiavo

Aruna Shanbaug – Indian woman in persistent vegetative state for 42 years until her death. Due to her case, the Supreme Court of India allowed passive euthanasia in the country.

Ariel Sharon

Chayito Valdez

Vice Vukov

Helga Wanglie

Otto Warmbier

See also[edit]

Anencephaly

Brain death

Botulism

Catatonia

Karolina Olsson

Locked-in syndrome

Process Oriented Coma Work, for an approach to working with residual consciousness in patients in comatose and persistent vegetative states

References[edit]

^ Laureys, Steven; Celesia, Gastone G; Cohadon, Francois; Lavrijsen, Jan; León-Carrión, José; Sannita, Walter G; Sazbon, Leon; Schmutzhard, Erich; von Wild, Klaus R (2010-11-01). "Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome". BMC Medicine. 8: 68. doi:10.1186/1741-7015-8-68. ISSN 1741-7015. PMC 2987895. PMID 21040571.

^ Laureys S, Celesia GG, Cohadon F, Lavrijsen J, León-Carrión J, Sannita WG, Sazbon L, Schmutzhard E, von Wild KR, Zeman A, Dolce G (2010). "Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome". BMC Med. 8: 68. doi:10.1186/1741-7015-8-68. PMC 2987895. PMID 21040571.

^ Jump up to: a b Royal College of Physicians 2013 Prolonged Disorders of Consciousness: National Clinical Guidelines, www.rcplondon.ac.uk/resources/prolonged-disorders-conscio...

^ Jennett, B (1999). "Should cases of permanent vegetative state still go to court?. Britain should follow other countries and keep the courts for cases of dispute". BMJ (Clinical Research Ed.). 319 (7213): 796–97. doi:10.1136/bmj.319.7213.796. PMC 1116645. PMID 10496803.

^ Royal College of Physicians 2013 Prolonged Disorders of Consciousness: National Clinical Guidelines

^ Jump up to: a b c Diagnosing The Permanent Vegetative State by Ronald Cranford, MD

^ PVS, The Multi-Society Task Force on (1994-05-26). "Medical Aspects of the Persistent Vegetative State". New England Journal of Medicine. 330 (21): 1499–1508. doi:10.1056/NEJM199405263302107. ISSN 0028-4793. PMID 7818633.

^ Jump up to: a b Wade, DT; Johnston, C (1999). "The permanent vegetative state: Practical guidance on diagnosis and management". BMJ (Clinical Research Ed.). 319 (7213): 841–4. doi:10.1136/bmj.319.7213.841. PMC 1116668. PMID 10496834.

^ Guidance on diagnosis and management: Report of a working party of the Royal College of Physicians. Royal College of Physicians: London. 1996.

^ Jump up to: a b c Bryan Jennett. The Vegetative State: Medical facts, ethical and legal dilemmas (PDF). University of Glasgow: Scotland. Retrieved 2007-11-09.

^ Post-coma unresponsiveness (Vegetative State): a clinical framework for diagnosis. National Health and Medical Research Council (NHMRC): Canberra. 2003. Archived from the original on 2006-08-20.

^ Jennett, B (2002). "Editorial: The vegetative state. The definition, diagnosis, prognosis and pathology of this state are discussed, together with the legal implications". British Medical Journal. 73 (4): 355–357. doi:10.1136/jnnp.73.4.355. PMC 1738081. PMID 12235296. Retrieved 2012-06-11.

^ "New Scientist". 2014-02-02. Archived from the original on 2017-07-11. Retrieved 2019-01-07.

^ Nell Boyce (July 8, 2000). "Is anyone in there?". New Scientist: 36.

^ Schapira, Anthony (December 18, 2006). Neurology and Clinical Neuroscience. Mosby. p. 126. ISBN 978-0323033541.

^ Mirsattari SM, Hammond RR, Sharpe MD, Leung FY, Young GB (April 2004). "Myoclonic status epilepticus following repeated oral ingestion of colloidal silver". Neurology. 62 (8): 1408–10. doi:10.1212/01.WNL.0000120671.73335.EC. PMID 15111684.

^ K Andrews; L Murphy; R Munday; C Littlewood (1996-07-06). "Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit". British Medical Journal. 313 (7048): 13–16. doi:10.1136/bmj.313.7048.13. PMC 2351462. PMID 8664760.

^ Giacino JT, et al. (2002). "Unknown title". Neurology. 58 (3): 349–353. doi:10.1212/wnl.58.3.349. PMID 11839831.

^ Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD (2006-09-08). "Detecting awareness in the vegetative state". Science. 313 (5792): 1402. CiteSeerX 10.1.1.1022.2193. doi:10.1126/science.1130197. PMID 16959998.

^ "Vegetative patient 'communicates': A patient in a vegetative state can communicate just through using her thoughts, according to research". BBC News. September 7, 2006. Retrieved 2008-08-14.

^ Stein R (September 8, 2006). "Vegetative patient's brain active in test: Unprecedented experiment shows response to instructions to imagine playing tennis". San Francisco Chronicle. Retrieved 2007-09-26.

^ Willful Modulation of Brain Activity in Disorders of Consciousness at nejm.org

^ Jump up to: a b Richard Alleyne and Martin Beckford, Patients in 'vegetative' state can think and communicate,Telegraph (United Kingdom), Feb 4, 2010

^ Cruse Damian; et al. (2011). "Bedside detection of awareness in the vegetative state: a cohort study". The Lancet. 378 (9809): 2088–2094. CiteSeerX 10.1.1.368.3928. doi:10.1016/S0140-6736(11)61224-5. PMID 22078855.

^ Dolce, Giuliano; Sazbon, Leon (2002). The post-traumatic vegetative state. ISBN 9781588901163.

^ Georgiopoulos M, et al. (2010). "Vegetative state and minimally conscious state: a review of the therapeutic interventions". Stereotact Funct Neurosurg. 88 (4): 199–207. doi:10.1159/000314354. PMID 20460949.

^ Georgiopoulos, M; Katsakiori, P; Kefalopoulou, Z; Ellul, J; Chroni, E; Constantoyannis, C (2010). "Vegetative state and minimally conscious state: a review of the therapeutic interventions". Stereotactic and Functional Neurosurgery. 88 (4): 199–207. doi:10.1159/000314354. PMID 20460949.

^ Snyman, N; Egan, JR; London, K; Howman-Giles, R; Gill, D; Gillis, J; Scheinberg, A (2010). "Zolpidem for persistent vegetative state—a placebo-controlled trial in pediatrics". Neuropediatrics. 41 (5): 223–227. doi:10.1055/s-0030-1269893. PMID 21210338.

^ Whyte, J; Myers, R (2009). "Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial". Am J Phys Med Rehabil. 88 (5): 410–418. doi:10.1097/PHM.0b013e3181a0e3a0. PMID 19620954.

^ Hirsch, Joy (2005-05-02). "Raising consciousness". The Journal of Clinical Investigation. 115 (5): 1102. doi:10.1172/JCI25320. PMC 1087197. PMID 15864333.

^ Ernst Kretschmer (1940). "Das apallische Syndrom". Neurol. Psychiat. 169: 576–579. doi:10.1007/BF02871384.

^ B Jennett; F Plum (1972). "Persistent vegetative state after brain damage: A syndrome in search of a name". The Lancet. 1 (7753): 734–737. doi:10.1016/S0140-6736(72)90242-5. PMID 4111204.

^ Appel on Betancourt v. Trinitas

^ Jump up to: a b c d Richard Alleyne and Martin Beckford, Patients in 'vegetative' state can think and communicate, Telegraph (United Kingdom), Feb 4, 2010

This article contains text from the NINDS public domain pages on TBI. [1] and [2].

 

External links[edit]

Sarà, M.; Sacco, S.; Cipolla, F.; Onorati, P.; Scoppetta, C; Albertini, G; Carolei, A (2007). "An unexpected recovery from permanent vegetative state". Brain Injury. 21 (1): 101–103. doi:10.1080/02699050601151761. PMID 17364525.

Canavero S, et al. (2009). "Recovery of consciousness following bifocal extradural cortical stimulation in a permanently vegetative patient". Journal of Neurology. 256 (5): 834–6. doi:10.1007/s00415-009-5019-4. PMID 19252808.

Canavero S (editor) (2009). Textbook of therapeutic cortical stimulation. New York: Nova Science. ISBN 9781606925379.

Canavero S, Massa-Micon B, Cauda F, Montanaro E (May 2009). "Bifocal extradural cortical stimulation-induced recovery of consciousness in the permanent post-traumatic vegetative state". J Neurol. 256 (5): 834–6. doi:10.1007/s00415-009-5019-4. PMID 19252808.

Connolly, Kate. "Car crash victim trapped in a coma for 23 years was conscious", The Guardian, November 23, 2009.

Machado, Calixto, et al. "A Cuban Perspective on Management of Persistent Vegetative State". MEDICC Review 2012;14(1):44–48.

 

en.wikipedia.org/wiki/Persistent_vegetative_state

Original Caption: Constitution Beach - Within Sight and Sound of Logan Airport's Takeoff Runway. 22r 07/1973

 

U.S. National Archives’ Local Identifier: 412-DA-5981

 

Photographer: Manheim, Michael Philip, 1940-

 

Subjects:

East Boston (Boston, Suffolk county, Massachusetts, United States) neighborhood

Environmental Protection Agency

Project DOCUMERICA

 

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Access Restrictions: Unrestricted

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Bain News Service,, publisher.

 

Hamlin

 

[between ca. 1915 and ca. 1920]

 

1 negative : glass ; 5 x 7 in. or smaller.

 

Notes:

Title from unverified data provided by the Bain News Service on the negatives or caption cards.

Forms part of: George Grantham Bain Collection (Library of Congress).

 

Format: Glass negatives.

 

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Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

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Call Number: LC-B2- 4966-2

  

La persistenza della memoria. - Roma, ex scritta "Tabacchi" nello sfondo

Persistent people begin their success where others end in failure.

Edward Eggleston

"Arts of War: Valor" by Leo Friedlander (1950)

Muybridge, Eadweard,, 1830-1904,, photographer.

 

Skeleton of horse. Trotting. On the ground

 

[San Francisco] : Muybridge, c1881.

 

1 photographic print : albumen.

 

Notes:

Illus. in: The attitudes of animals in motion : a series of photographs illustrating the consecutive positions assumed by animals in performing various movements; executed at Palo Alto, California, in 1878 and 1879, no. 197.

Copyright 1881 by Edw. J. Muybridge.

Title from "Index to Illustrations" in book. See LC-USZC4-13693, LC-USZC4-13694, and LC-USZC4-13695 for images of this index.

Photograph shows a skeleton of a horse trotting.

 

Subjects:

Skeletons--California--Palo Alto--1870-1880.

Animal locomotion--California--Palo Alto--1870-1880.

 

Format: Motion study photographs--1880-1890.

Book illustrations--1880-1890.

Albumen prints--1880-1890.

 

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Call Number: Illus. in QP301 .M75

  

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Subject (TGM): Women's education; Teachers' colleges; Students; Group portraits;

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Subject (TGM): Children; Girls; Rabbits; Animals; Birds; Easter cards; Easter egg hunts; Flowers; Grocery stores; Dry goods stores;

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Bain News Service,, publisher.

 

Easton

 

[between ca. 1920 and ca. 1925]

 

1 negative : glass ; 5 x 7 in. or smaller.

 

Notes:

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Forms part of: George Grantham Bain Collection (Library of Congress).

 

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Part Of: Bain News Service photograph collection (DLC) 2005682517

 

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Call Number: LC-B2- 5735-6

 

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Subject (TGM): Animals in human situations; Cats; Caricatures; Patent medicines;

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Subject (TGM): Children; Girls; Hats; Flowers; Perfumes; Dressing & grooming equipment; Cosmetics & soap; Pharmacists; Drugstores;

Margolies, John,, photographer.

 

Petrified Rockery /Dutch prospector statue, Route 64, Valle, Arizona

 

1987.

 

1 photograph : color transparency ; 35 mm (slide format).

 

Notes:

Title, date and keywords based on information provided by the photographer.

Purchase; John Margolies 2010 (DLC/PP-2010:191).

Credit line: John Margolies Roadside America photograph archive (1972-2008), Library of Congress, Prints and Photographs Division.

Please use digital image: original slide is kept in cold storage for preservation.

Forms part of: John Margolies Roadside America photograph archive (1972-2008).

 

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Sculpture--1980-1990.

United States--Arizona--Valle.

 

Format: Slides--1980-1990.--Color

 

Rights Info: No known restrictions on publication. For more information, see "John Margolies Roadside America Photograph Archive - Rights and Restrictions Information" www.loc.gov/rr/print/res/723_marg.html

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

Part Of: Margolies, John John Margolies Roadside America photograph archive (DLC) 2010650110

 

General information about the John Margolies Roadside America photograph archive is available at hdl.loc.gov/loc.pnp/pp.mrg

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/mrg.02355

 

Call Number: LC-MA05- 2355

 

Margolies, John,, photographer.

 

City Hall, angle 1, Broadway & Cook Street, Santa Maria, California

 

1977.

 

1 photograph : color transparency ; 35 mm (slide format).

 

Notes:

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Margolies categories: Public buildings; Main Street.

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Please use digital image: original slide is kept in cold storage for preservation.

Forms part of: John Margolies Roadside America photograph archive (1972-2008).

 

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United States--California--Santa Maria.

 

Format: Slides--1970-1980.--Color

 

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Part Of: Margolies, John John Margolies Roadside America photograph archive (DLC) 2010650110

 

General information about the John Margolies Roadside America photograph archive is available at hdl.loc.gov/loc.pnp/pp.mrg

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/mrg.01008

 

Call Number: LC-MA05- 1008

 

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Persistent URL: digital.lib.muohio.edu/u?/tradecards,2339

 

Subject (TGM): Tomatoes; Vegetables; Fruit; Truck farming; Gardening; Gardens; Farm produce; Caricatures; Men; Humorous pictures; Seed trade; Seeds;

Bain News Service,, publisher.

 

Kreisler

 

[between ca. 1915 and ca. 1920]

 

1 negative : glass ; 5 x 7 in. or smaller.

 

Notes:

Title from unverified data provided by the Bain News Service on the negatives or caption cards.

Forms part of: George Grantham Bain Collection (Library of Congress).

 

Format: Glass negatives.

 

Rights Info: No known restrictions on publication.

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

General information about the Bain Collection is available at hdl.loc.gov/loc.pnp/pp.ggbain

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/ggbain.28495

 

Call Number: LC-B2- 4877-8

  

Persistent URL: digital.lib.muohio.edu/u?/tradecards,3540

 

Subject (TGM): Corsets; Lingerie; Clothing & dress; Clothing industry; Angels; Cupids; Testimonials;

Persistent URL: digital.lib.muohio.edu/u?/tradecards,3206

 

Subject (TGM): Angels; Cupids; Baking powder; Tree limbs; Flowers;

Bain News Service,, publisher.

 

Farewell to 165th

 

[between ca. 1915 and ca. 1920]

 

1 negative : glass ; 5 x 7 in. or smaller.

 

Notes:

Title from unverified data provided by the Bain News Service on the negatives or caption cards.

Forms part of: George Grantham Bain Collection (Library of Congress).

 

Format: Glass negatives.

 

Rights Info: No known restrictions on publication.

 

Repository: Library of Congress, Prints and Photographs Division, Washington, D.C. 20540 USA, hdl.loc.gov/loc.pnp/pp.print

 

General information about the Bain Collection is available at hdl.loc.gov/loc.pnp/pp.ggbain

 

Higher resolution image is available (Persistent URL): hdl.loc.gov/loc.pnp/ggbain.25184

 

Call Number: LC-B2- 4314-6

  

Persistent URL: www.floridamemory.com/items/show/253257

 

Title: Hotel Beach Party

 

Date of film: 1967

 

Physical descrip: color; sound; original length: 8:30

 

General note: Katherine Spaak, Kevin McCarthy, Gypsy Rose Lee, Henny Youngman, Richard Conte, Merle Oberon, columnist Virginia Graham, producer Wendel Mays, author Arthur Hailey, director Richard Kline and costume designer Edith Head all attend the press premiere of the film "Hotel." Everyone meets the reporters and photographers, eats and has a good time. A helicopter films from above. The location is Hotel Row, Miami Beach. Produced by Peter Barton Productions; sponsored by FDC in cooperation with Warner Bros.

To see full-length versions of this and other videos from the State Archives of Florida, visit www.floridamemory.com/video/.

 

Repository: State Library and Archives of Florida, 500 S. Bronough St., Tallahassee, FL 32399-0250 USA. Contact: 850.245.6700. Archives@dos.myflorida.com

  

Persistent URL: digital.lib.muohio.edu/u?/tradecards,4073

 

Subject (TGM): Coffee industry; Landscape prints; Winter; Flowers; Birds;

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