Help me to understand, please?

President George W. Bush moderates a conversation with General Peter Chiarelli, USMC Veteran Brian Stann and USMC Veteran Dave Smith on veteran transition. bit.ly/1LaBscu

 

Photo by Grant Miller for the George W. Bush Presidential Center

Moderated High-Level Policy Session 14: Knowledge societies,

capacity building and e-learning / Media

 

Speaking: Ms. Doreen Bogdan-Martin, Strategic Planning and Membership Department, WSIS Action Line Facilitator ITU

 

©ITU/R.Farrell

Imran Qureishi, Pakistan

A moderate amount of Fluttershy stuff.

 

Fluttershy.

Fluttershy keychain, Fluttershy sticker, buttons.

cartoon: My Little Pony Friendship Is Magic.

 

Baltimore Convention Center, Baltimore, Maryland.

 

August 4, 2013.

  

... Read my blog at ClintJCL at wordpress.com

  

BACKSTORY: We went to BronyCon this year! Over 8,000 people showed up. This was the only time we really spent the whole weekend there -- the following year (2014), we only went for a few hours on the way back from an exhausting family vacation, and the year after that (2015), we didn't go at all. Attendance is over 10,000 nowadays. Frickin' crazy.

Sihanoukville (Khmer: ក្រុងព្រះសីហនុ, Krong Preah Sihanouk), also known as 'Kompong Som' (Khmer: កំពង់សោម), is a coastal city in Cambodia and the capital city of Sihanoukville Province, located at the tip of an elevated peninsula in the country's south-west at the Gulf of Thailand. The city is flanked by an almost uninterrupted string of beaches along its entire coastline and coastal marshlands bordering the Ream National Park in the East. A number of thinly inhabited islands - under Sihanoukville's administration - are in the city's proximity, where in recent years moderate development has helped to attract a sizable portion of Asia's individual travelers, young students and back-packers.

 

The city, which was named in honour of former king Norodom Sihanouk, had a population of around 89.800 people and approximately 66.700 in its urban center in 2008. Sihanoukville city encompasses the greater part of four of the five communes (Sangkats) of Sihanoukville provinces' Mittakpheap District. A relatively young city, it has evolved parallel to the construction of the Sihanoukville Autonomous Port, which commenced in June 1955, as the country's gateway to direct and unrestricted international sea trade. The only deep water port in Cambodia includes a mineral oil terminal and a transport logistics facility. As a consequence, the city grew to become a leading national center of trade, commerce, transport and process manufacturing.

 

Sihanoukville's many beaches and nearby islands make it Cambodia's premier seaside resort with steadily rising numbers of national visitors and international tourists since the late 20th century. As a result of its economic diversity, the region's natural beauty and the considerable recreational potential, a constantly increasing number of seasonal and permanent foreign residents make Sihanoukville one of the culturally most varied and dynamic population centers in Cambodia. As of 2014 the tourism sector remains insignificant in comparison with neighboring Thailand. Sihanoukville's future will largely be defined by the authorities' capability of a successfully balanced management in order to protect and conserve natural resources on the one hand and the necessities of island - and urban development, increasing visitor numbers, expanding infrastructure, the industrial sector and population growth on the other.

 

Despite being the country’s premier sea side destination, after decades of war and upheaval the town and its infrastructure remain very much disjointed and architecturally unimpressive. Infrastructure problems persist, in particular related to water and power supply, while international standard health facilities remain limited.

 

ETYMOLOGY

The official name of the city in Khmer is: Krong (city) Preah (holy) Sihanouk (name of the former king), which adds up to: "City of the holy Sihanouk" or "Honorable Sihanouk City". King Norodom Sihanouk (reigned 1941-1955, 1993-2004) was and still is revered as father of the (modern) nation. The name "Sihanouk" is derived from Sanskrit through two Pali words: Siha (lion), and Hanu (jaws).

 

The alternative name, Kompong Saom (also romanized as Kompong Som and Kampong Som), (Khmer: កំពង់សោម) means "Port of the Moon" or "Shiva's Port". Saom is derived from the Sanskrit word "saumya", the original (Rig Vedic) meaning of which was "Soma, the juice or sacrifice of the moon-god", but evolved into Pali "moon", "moonlike" "name of Shiva". The word Kampong or Kompong is of Malayan origin and means village or hamlet. Its meaning underwent extension towards pier or river landing bridge.

 

HISTORY

CLASSICAL PERIOD (BEFORE 1700)

Prior to the ports' and city's foundation works of 1955, the port of Kompong Som must have been only of regional significance - due to the absence of navigable waterways that connect the port with the kingdom's settlement centers. During the many centuries of pre-Angkorian and Angkorian history – from Funan to Chenla and during the Khmer Empire, regional trade was centered at O Keo (Vietnamese: Óc Eo) in the Mekong Delta, now the province of Rạch Giá in Vietnam. The township of Prei Nokor (Saigon) was a commercial center of the Khmer Empire. The Chronicle of Samtec Cauva Vamn Juon - one of the 18th and 19th century Cambodian Royal Chronicles - briefly mentions the region as the country was split into 3 parts during a 9-year civil war from 1476 to 1485: "In 1479, Dhammaraja took on the throne at Catumukh (Phnom Penh) and controlled the provinces of Samraong Tong, Thbong, Kompong Saom, Kampot up to the Bassak, Preah Trapeang, Kramuon Sah, Koh Slaket and Peam"[mouth of the Mekong].

 

EARLY MODERN PERIOD (AROUND 1700-1863)

From the end of the seventeenth century, Cambodia lost control of the Mekong River route as Vietnamese power expanded into the lower Mekong. During the Nguyen-Siamese War (1717–18) a Siamese fleet burned the port of Kompong Som in 1717 but was defeated by the Vietnamese at Banteay Meas/Ha Tien.[20] A Cambodian king of the late eighteenth century, Outey-Reachea III allied with a Chinese pirate, Mac-Thien-Tu, who had established an autonomous polity based in Ha Tien and controlled the maritime network on the eastern part of the Gulf of Thailand. Ha Tien was located at a point where a river linking to the Bassac River flows into the Gulf of Thailand. Landlocked Cambodia tried to keep its access to maritime trade through Ha Tien. In 1757 Ha Tien acquired the ports of Kampot and Kompong Som as a reward for Mac's military support to the King of Cambodia. Until its destruction in 1771 the port developed into an independent duty-free entrepot - linked with several Chinese trading networks.

 

Alexander Hamilton, who traveled on the Gulf of Thailand in 1720, wrote that "Kompong Som and Banteay Meas (later Ha Tien) belonged to Cambodia, as Cochin-China was divided from Cambodia by a river (Bassac river) of three leagues broad." and "King Ang Duong constructed a road from his capital of Oudong to Kampot". Kampot remained the only international seaport of Cambodia. "The traveling time between Udong and Kampot was eight days by oxcart and four days by elephants." French Résident Adhemard Leclère wrote: "...Until 1840s, the Vietnamese governed Kampot and Péam [Mekong Delta], but Kompong Som belonged to Cambodia. The Vietnamese constructed a road from Ha Tien to Svai village - on the border with Kompong-Som - via Kampot."

 

The British Empire followed a distinct policy by the 1850s, seeking to consolidate its influence. Eye witness reports give rare insights, as Foreign Secretary Lord Palmerston's agent John Crawfurd reports: "Cambodia was...the Keystone of our policy in these countries, - the King of that ancient Kingdom is ready to throw himself under the protection of any European nation...The Vietnamese were interfering with the trade at Kampot, and this would be the basis of an approach..." Palmerston concluded: "The trade at Kampot - one of the few remaining ports, could never be considerable, in consequence of the main entrance to the country, the Mekong, with all its feeders flowing into the Sea through the territory of Cochin China The country, too, had been devastated by recent Siam - Vietnam wars. Thus, without the aid of Great Britain, Kampot or any other port in Cambodia, can never become a commercial Emporium." Crawfurd later wrote: "The Cambodians... sought to use intervals of peace in the Siam - Vietnam wars to develop intercourse with outside nations. The trade at Kampot which they sought to foster was imperiled by pirates. Here is a point where the wedge might be inserted, that would open the interior of the Indo-Chinese Peninsula to British Commerce, as the great River of the Cambodians traverses its entire length and even affords communication into the heart of Siam".

 

FRENCH RULE (1863-1954)

Under French rule Vietnam, Laos and Cambodia became a single administrative and economic unit. The coastal region Circonscription Résidentielle with Kampot as its capital contained the Arrondissements of Kampot, Kompong Som, Trang and Kong-Pisey. The establishment of another international trading center near the existing city of Saigon was not considered necessary. Focus remained the Mekong and the idea to establish an alternative route to Chinese and Thai internal markets along an uninterrupted navigable waterway from the Red River to the Mekong Delta.

 

INSURRECTION

An insurrection that took place from 1885 to 1887 further discouraged French ambition. It started in Kampot and quickly spread to Veal Rinh, Kampong Seila, and Kompong Som, where the insurgents were led by a Chinese pirate named Quan-Khiem. He managed to control the northern part of Preah Sihanouk for some time until he - an old man - was arrested by Preah Sihanouk's governor.

 

The most notable infrastructural improvements of this period were the construction of Route Coloniale No.17, later renamed National Road No.3 and the national railway system, although work on the "Southern Line" - from Phnom Penh to Sihanoukville - only began in 1960.

 

AFTER INDIPENDENCE (SINCE 1954)

The city's and province's alternative name Kampong som (Kampong Som) was adopted from the local indigenous community. After the dissolution of French Indochina in 1954, it became apparent that the steadily tightening control of the Mekong Delta by Vietnam required a solution to gain unrestricted access to the seas. Plans were made to construct an entirely new deep-water port. Kompong Saom (Kampong Som) was selected for water depth and ease of access. In August 1955, a French/Cambodian construction team cut a base camp into the unoccupied jungle in the area that is now known as Hawaii Beach. Funds for construction of the port came from France and the road was financed by the USA.

 

During the Vietnam War the port became an intensive military facility on both sides, in the service of National Front for the Liberation of South Vietnam and after 1970, under the government of Lon Nol, in the service of the United States.

 

The port was the last place to be evacuated by the US Army, only days before Khmer Rouge guerrillas took control of the government in April 1975. The events surrounding the taking of the US container ship SS Mayaguez and its crew on 12 May by the Khmer Rouge and the subsequent rescue operation by US Marines played out on the waters of Koh Tang off the coast of Sihanoukville. During the two days of action, the US commenced air strikes on targets on the mainland of Sihanoukville including the port, the Ream Naval Base, an airfield, the railroad yard and the petroleum refinery in addition to strikes and naval gun fire on several islands.

 

After the fall of the Khmer Rouge regime in 1979 and the subsequent opening of the economy, the port of Sihanoukville resumed its importance in the development and recovery of the country. With the further opening of new markets in 1999, the city regained its role in the economic growth of Cambodia.

 

In 1993, the Ream National Park was established per royal decree of former King Sihanouk.

 

The Sihanoukville Municipality was elevated to a regular province on 22 December 2008 after King Norodom Sihamoni signed a Royal Decree converting the municipalities of Kep, Pailin and Sihanoukville into provinces.

 

In 2006 the Koh Puos (Cambodia) Investment Group submitted an application, planning to invest $276 million in converting the 116-hectare Koh Puos - Snake island into a luxury residential - and resort complex. After the completion of certain elements of the infrastructure, the investor announced alterations of the original blueprints, as "Reapplying for permission will happen in 2014..." according to the Council of the Development of Cambodia.

 

On 26 May 2011 Preah Sihanouk area joined the Paris-based club Les Plus Belles Baies Du Monde (The most Beautiful Bays in the World). The organisation officially accepts the Bay of Cambodia as one of its members at the 7th General Assembly.

 

BEACHES

Sihanoukville's beaches are one of the city's most valuable ecological and economic resource with varying degrees of commercial exploitation. The beaches listed in this section do not include any of the island's beaches.

 

- Ochheuteal Beach, ឆ្នេរអូរឈើទាល: is a 3.3 km long strip of white sand beach and although the name translates to "Creek/Estuary of the Tiel tree" it is lined with Casuarina and Tamarisk trees. Grass umbrellas, rental chairs in front of around 30 standardized beach huts serve meals, drinks and entertainment. Well established middle class hotels and high-profile residences flank the beach along its Northern part. The sustainability of Ochheuteal beach was a primary consideration of various stakeholders, which brought about the development of a tourism development and management plan in 2005. The Southern half remains - apart from some hotels at its far end - essentially undeveloped.

 

- Serendipity Beach: Technically the western end (roughly one fifth or 600 m) of Ochheuteal beach, is very popular with Western tourists and has a few small guesthouses right on the beach. It has been named by an American fellow, who came here in the Nineties. Struck by its (then) unspoiled beauty and pristine condition, he came up with the term, which quickly entered common vocabulary.

 

- Otres Beach, ្នេរអូរត្រេស: is around 4.6 km long and beyond the small "Queen hill" headland at the southern end of Ochheuteal Beach. Its long white sand strip, also completely lined with Casuarina and Tamarisk trees, is far less developed and commercialized than Ochheuteal Beach and has developed into a preferred lodging place for Western visitors. From 2004 to 2011 this beach was occupied by numerous bungalows and dormitories, run by Western people. Due to the element of illegality of on-beach accommodation, among other reasons, police cleaned up the area in May 2011, removing the greater part of the beach-side bungalows. Permanent structures beyond the beach road supplement the remaining places since 2012. It is a very popular, well established holiday retreat – where prices have risen considerably over the course of the last years.

 

- Sokha Beach: Sokha Beach is around 1.2 km long and located west of Serendipity Beach. The beach is privately owned by - and its southern half occupied by the Sokha Beach Hotel, the first five-star luxury beach hotel in Cambodia. While the beach is well kept and many facilities are provided, visitors have to pay for their use and beach vendors are not allowed.

 

- Independence Beach: Independence Beach is around 1.3 km long and located north-west of Sokha Beach. The beach is named after the Independence Hotel, another example of New Khmer Architecture, towering on top of a rock at the beaches northern end.

 

- Victory Beach: Victory beach is around 300 m long and situated at the furthest north of the peninsula of Sihanoukville. It was heavily used by backpackers and is still popular with budget travelers. The deep water port is located at the northern end of the beach. A consortium of Russian business people undertook large scale development here. The beach is regularly maintained.

 

- Lamherkay/Hawaii Beach: is the southern succession of Victory Beach, situated north of Independence Beach. It is a strip of similar length as Victory Beach - around 300 m. Here is the very place where the French/Cambodian construction team's groundwork began for the construction of the Sihanoukville Autonomous Port in 1955.

 

- Treasure Island Beach south of Lamherkay/Hawaii Beach is less than 50 m long and its entire length is fringed with concrete steps and wooden pavilions of a big Cambodian seafood restaurant.

 

- Hun Sen (Prek Treng) Beach, ឆ្នេរព្រែកត្រែង: is the northernmost beach of the city with a length of around 1.5 km, situated behind the local port and essentially empty without beach huts and bars, it sees only weekend - and holiday visitors. The water is very shallow, but the area is lacking favorable infrastructure and is not regularly cleaned.

 

WIKIPEDIA

Moderate coverage. Fully lined. Adjustable back hook closure, and includes a removable wide tie strap. High waist banded bottom. Made by quality fabrics, Sexy Flowery Bandeau Top provides a smooth silhouette with a silky-soft feel.Need Multifunctional Beach Sarong sales independent.

Moderate air quality in upstate New York today

Dr. Ellen Stofan, chief scientist, NASA, moderates a panel titled, "Not Just to Visit, but to Stay," including, Heather Hava, University of Colorado; Jason Dunn, Made in Space; Red Whittaker, Astrobotic; and NASA astronaut Serena Auñon Chancellor; at the White House Frontiers Conference Thursday, October 13, 2016 at Carnegie Mellon University in Pittsburgh, PA. The White House Frontiers Conference, hosted by President Obama, and co-hosted by the University of Pittsburgh and Carnegie Mellon University, explores the future of innovation with a focus on building U.S. capacity in science and technology. Photo Credit: (NASA/Aubrey Gemignani)

LOGO Sadie Omega Head [DBF] Aurora skin (Sand)

 

Visit this location at Silversides (118,42) Moderate 3184m in Second Life

Left: Moderate squamous dysplasia (CIN2, HGSIL). Right: High grade dysplasia (CIN2) on Thin Prep pap.

Fish, any of approximately 34,000 species of vertebrate animals (phylum Chordata) found in the fresh and salt waters of the world. Living species range from the primitive jawless lampreys and hagfishes through the cartilaginous sharks, skates, and rays to the abundant and diverse bony fishes. Most fish species are cold-blooded; however, one species, the opah (Lampris guttatus), is warm-blooded.

 

The term fish is applied to a variety of vertebrates of several evolutionary lines. It describes a life-form rather than a taxonomic group. As members of the phylum Chordata, fish share certain features with other vertebrates. These features are gill slits at some point in the life cycle, a notochord, or skeletal supporting rod, a dorsal hollow nerve cord, and a tail. Living fishes represent some five classes, which are as distinct from one another as are the four classes of familiar air-breathing animals—amphibians, reptiles, birds, and mammals. For example, the jawless fishes (Agnatha) have gills in pouches and lack limb girdles. Extant agnathans are the lampreys and the hagfishes. As the name implies, the skeletons of fishes of the class Chondrichthyes (from chondr, “cartilage,” and ichthyes, “fish”) are made entirely of cartilage. Modern fish of this class lack a swim bladder, and their scales and teeth are made up of the same placoid material. Sharks, skates, and rays are examples of cartilaginous fishes. The bony fishes are by far the largest class. Examples range from the tiny seahorse to the 450-kg (1,000-pound) blue marlin, from the flattened soles and flounders to the boxy puffers and ocean sunfishes. Unlike the scales of the cartilaginous fishes, those of bony fishes, when present, grow throughout life and are made up of thin overlapping plates of bone. Bony fishes also have an operculum that covers the gill slits.

 

The study of fishes, the science of ichthyology, is of broad importance. Fishes are of interest to humans for many reasons, the most important being their relationship with and dependence on the environment. A more obvious reason for interest in fishes is their role as a moderate but important part of the world’s food supply. This resource, once thought unlimited, is now realized to be finite and in delicate balance with the biological, chemical, and physical factors of the aquatic environment. Overfishing, pollution, and alteration of the environment are the chief enemies of proper fisheries management, both in fresh waters and in the ocean. (For a detailed discussion of the technology and economics of fisheries, see commercial fishing.) Another practical reason for studying fishes is their use in disease control. As predators on mosquito larvae, they help curb malaria and other mosquito-borne diseases.

 

Fishes are valuable laboratory animals in many aspects of medical and biological research. For example, the readiness of many fishes to acclimate to captivity has allowed biologists to study behaviour, physiology, and even ecology under relatively natural conditions. Fishes have been especially important in the study of animal behaviour, where research on fishes has provided a broad base for the understanding of the more flexible behaviour of the higher vertebrates. The zebra fish is used as a model in studies of gene expression.

 

There are aesthetic and recreational reasons for an interest in fishes. Millions of people keep live fishes in home aquariums for the simple pleasure of observing the beauty and behaviour of animals otherwise unfamiliar to them. Aquarium fishes provide a personal challenge to many aquarists, allowing them to test their ability to keep a small section of the natural environment in their homes. Sportfishing is another way of enjoying the natural environment, also indulged in by millions of people every year. Interest in aquarium fishes and sportfishing supports multimillion-dollar industries throughout the world.

 

Fishes have been in existence for more than 450 million years, during which time they have evolved repeatedly to fit into almost every conceivable type of aquatic habitat. In a sense, land vertebrates are simply highly modified fishes: when fishes colonized the land habitat, they became tetrapod (four-legged) land vertebrates. The popular conception of a fish as a slippery, streamlined aquatic animal that possesses fins and breathes by gills applies to many fishes, but far more fishes deviate from that conception than conform to it. For example, the body is elongate in many forms and greatly shortened in others; the body is flattened in some (principally in bottom-dwelling fishes) and laterally compressed in many others; the fins may be elaborately extended, forming intricate shapes, or they may be reduced or even lost; and the positions of the mouth, eyes, nostrils, and gill openings vary widely. Air breathers have appeared in several evolutionary lines.

 

Many fishes are cryptically coloured and shaped, closely matching their respective environments; others are among the most brilliantly coloured of all organisms, with a wide range of hues, often of striking intensity, on a single individual. The brilliance of pigments may be enhanced by the surface structure of the fish, so that it almost seems to glow. A number of unrelated fishes have actual light-producing organs. Many fishes are able to alter their coloration—some for the purpose of camouflage, others for the enhancement of behavioral signals.

 

Fishes range in adult length from less than 10 mm (0.4 inch) to more than 20 metres (60 feet) and in weight from about 1.5 grams (less than 0.06 ounce) to many thousands of kilograms. Some live in shallow thermal springs at temperatures slightly above 42 °C (100 °F), others in cold Arctic seas a few degrees below 0 °C (32 °F) or in cold deep waters more than 4,000 metres (13,100 feet) beneath the ocean surface. The structural and, especially, the physiological adaptations for life at such extremes are relatively poorly known and provide the scientifically curious with great incentive for study.

 

Almost all natural bodies of water bear fish life, the exceptions being very hot thermal ponds and extremely salt-alkaline lakes, such as the Dead Sea in Asia and the Great Salt Lake in North America. The present distribution of fishes is a result of the geological history and development of Earth as well as the ability of fishes to undergo evolutionary change and to adapt to the available habitats. Fishes may be seen to be distributed according to habitat and according to geographical area. Major habitat differences are marine and freshwater. For the most part, the fishes in a marine habitat differ from those in a freshwater habitat, even in adjacent areas, but some, such as the salmon, migrate from one to the other. The freshwater habitats may be seen to be of many kinds. Fishes found in mountain torrents, Arctic lakes, tropical lakes, temperate streams, and tropical rivers will all differ from each other, both in obvious gross structure and in physiological attributes. Even in closely adjacent habitats where, for example, a tropical mountain torrent enters a lowland stream, the fish fauna will differ. The marine habitats can be divided into deep ocean floors (benthic), mid-water oceanic (bathypelagic), surface oceanic (pelagic), rocky coast, sandy coast, muddy shores, bays, estuaries, and others. Also, for example, rocky coastal shores in tropical and temperate regions will have different fish faunas, even when such habitats occur along the same coastline.

 

Although much is known about the present geographical distribution of fishes, far less is known about how that distribution came about. Many parts of the fish fauna of the fresh waters of North America and Eurasia are related and undoubtedly have a common origin. The faunas of Africa and South America are related, extremely old, and probably an expression of the drifting apart of the two continents. The fauna of southern Asia is related to that of Central Asia, and some of it appears to have entered Africa. The extremely large shore-fish faunas of the Indian and tropical Pacific oceans comprise a related complex, but the tropical shore fauna of the Atlantic, although containing Indo-Pacific components, is relatively limited and probably younger. The Arctic and Antarctic marine faunas are quite different from each other. The shore fauna of the North Pacific is quite distinct, and that of the North Atlantic more limited and probably younger. Pelagic oceanic fishes, especially those in deep waters, are similar the world over, showing little geographical isolation in terms of family groups. The deep oceanic habitat is very much the same throughout the world, but species differences do exist, showing geographical areas determined by oceanic currents and water masses.

 

All aspects of the life of a fish are closely correlated with adaptation to the total environment, physical, chemical, and biological. In studies, all the interdependent aspects of fish, such as behaviour, locomotion, reproduction, and physical and physiological characteristics, must be taken into account.

 

Correlated with their adaptation to an extremely wide variety of habitats is the extremely wide variety of life cycles that fishes display. The great majority hatch from relatively small eggs a few days to several weeks or more after the eggs are scattered in the water. Newly hatched young are still partially undeveloped and are called larvae until body structures such as fins, skeleton, and some organs are fully formed. Larval life is often very short, usually less than a few weeks, but it can be very long, some lampreys continuing as larvae for at least five years. Young and larval fishes, before reaching sexual maturity, must grow considerably, and their small size and other factors often dictate that they live in a habitat different than that of the adults. For example, most tropical marine shore fishes have pelagic larvae. Larval food also is different, and larval fishes often live in shallow waters, where they may be less exposed to predators.

 

After a fish reaches adult size, the length of its life is subject to many factors, such as innate rates of aging, predation pressure, and the nature of the local climate. The longevity of a species in the protected environment of an aquarium may have nothing to do with how long members of that species live in the wild. Many small fishes live only one to three years at the most. In some species, however, individuals may live as long as 10 or 20 or even 100 years.

 

Fish behaviour is a complicated and varied subject. As in almost all animals with a central nervous system, the nature of a response of an individual fish to stimuli from its environment depends upon the inherited characteristics of its nervous system, on what it has learned from past experience, and on the nature of the stimuli. Compared with the variety of human responses, however, that of a fish is stereotyped, not subject to much modification by “thought” or learning, and investigators must guard against anthropomorphic interpretations of fish behaviour.

 

Fishes perceive the world around them by the usual senses of sight, smell, hearing, touch, and taste and by special lateral line water-current detectors. In the few fishes that generate electric fields, a process that might best be called electrolocation aids in perception. One or another of these senses often is emphasized at the expense of others, depending upon the fish’s other adaptations. In fishes with large eyes, the sense of smell may be reduced; others, with small eyes, hunt and feed primarily by smell (such as some eels).

 

Specialized behaviour is primarily concerned with the three most important activities in the fish’s life: feeding, reproduction, and escape from enemies. Schooling behaviour of sardines on the high seas, for instance, is largely a protective device to avoid enemies, but it is also associated with and modified by their breeding and feeding requirements. Predatory fishes are often solitary, lying in wait to dart suddenly after their prey, a kind of locomotion impossible for beaked parrot fishes, which feed on coral, swimming in small groups from one coral head to the next. In addition, some predatory fishes that inhabit pelagic environments, such as tunas, often school.

 

Sleep in fishes, all of which lack true eyelids, consists of a seemingly listless state in which the fish maintains its balance but moves slowly. If attacked or disturbed, most can dart away. A few kinds of fishes lie on the bottom to sleep. Most catfishes, some loaches, and some eels and electric fishes are strictly nocturnal, being active and hunting for food during the night and retiring during the day to holes, thick vegetation, or other protective parts of the environment.

 

Communication between members of a species or between members of two or more species often is extremely important, especially in breeding behaviour (see below Reproduction). The mode of communication may be visual, as between the small so-called cleaner fish and a large fish of a very different species. The larger fish often allows the cleaner to enter its mouth to remove gill parasites. The cleaner is recognized by its distinctive colour and actions and therefore is not eaten, even if the larger fish is normally a predator. Communication is often chemical, signals being sent by specific chemicals called pheromones.

 

Many fishes have a streamlined body and swim freely in open water. Fish locomotion is closely correlated with habitat and ecological niche (the general position of the animal to its environment).

 

Many fishes in both marine and fresh waters swim at the surface and have mouths adapted to feed best (and sometimes only) at the surface. Often such fishes are long and slender, able to dart at surface insects or at other surface fishes and in turn to dart away from predators; needlefishes, halfbeaks, and topminnows (such as killifish and mosquito fish) are good examples. Oceanic flying fishes escape their predators by gathering speed above the water surface, with the lower lobe of the tail providing thrust in the water. They then glide hundreds of yards on enlarged, winglike pectoral and pelvic fins. South American freshwater flying fishes escape their enemies by jumping and propelling their strongly keeled bodies out of the water.

 

So-called mid-water swimmers, the most common type of fish, are of many kinds and live in many habitats. The powerful fusiform tunas and the trouts, for example, are adapted for strong, fast swimming, the tunas to capture prey speedily in the open ocean and the trouts to cope with the swift currents of streams and rivers. The trout body form is well adapted to many habitats. Fishes that live in relatively quiet waters such as bays or lake shores or slow rivers usually are not strong, fast swimmers but are capable of short, quick bursts of speed to escape a predator. Many of these fishes have their sides flattened, examples being the sunfish and the freshwater angelfish of aquarists. Fish associated with the bottom or substrate usually are slow swimmers. Open-water plankton-feeding fishes almost always remain fusiform and are capable of rapid, strong movement (for example, sardines and herrings of the open ocean and also many small minnows of streams and lakes).

 

Bottom-living fishes are of many kinds and have undergone many types of modification of their body shape and swimming habits. Rays, which evolved from strong-swimming mid-water sharks, usually stay close to the bottom and move by undulating their large pectoral fins. Flounders live in a similar habitat and move over the bottom by undulating the entire body. Many bottom fishes dart from place to place, resting on the bottom between movements, a motion common in gobies. One goby relative, the mudskipper, has taken to living at the edge of pools along the shore of muddy mangrove swamps. It escapes its enemies by flipping rapidly over the mud, out of the water. Some catfishes, synbranchid eels, the so-called climbing perch, and a few other fishes venture out over damp ground to find more promising waters than those that they left. They move by wriggling their bodies, sometimes using strong pectoral fins; most have accessory air-breathing organs. Many bottom-dwelling fishes live in mud holes or rocky crevices. Marine eels and gobies commonly are found in such habitats and for the most part venture far beyond their cavelike homes. Some bottom dwellers, such as the clingfishes (Gobiesocidae), have developed powerful adhesive disks that enable them to remain in place on the substrate in areas such as rocky coasts, where the action of the waves is great.

 

The methods of reproduction in fishes are varied, but most fishes lay a large number of small eggs, fertilized and scattered outside of the body. The eggs of pelagic fishes usually remain suspended in the open water. Many shore and freshwater fishes lay eggs on the bottom or among plants. Some have adhesive eggs. The mortality of the young and especially of the eggs is very high, and often only a few individuals grow to maturity out of hundreds, thousands, and in some cases millions of eggs laid.

 

Males produce sperm, usually as a milky white substance called milt, in two (sometimes one) testes within the body cavity. In bony fishes a sperm duct leads from each testis to a urogenital opening behind the vent or anus. In sharks and rays and in cyclostomes the duct leads to a cloaca. Sometimes the pelvic fins are modified to help transmit the milt to the eggs at the female’s vent or on the substrate where the female has placed them. Sometimes accessory organs are used to fertilize females internally—for example, the claspers of many sharks and rays.

 

In the females the eggs are formed in two ovaries (sometimes only one) and pass through the ovaries to the urogenital opening and to the outside. In some fishes the eggs are fertilized internally but are shed before development takes place. Members of about a dozen families each of bony fishes (teleosts) and sharks bear live young. Many skates and rays also bear live young. In some bony fishes the eggs simply develop within the female, the young emerging when the eggs hatch (ovoviviparous). Others develop within the ovary and are nourished by ovarian tissues after hatching (viviparous). There are also other methods utilized by fishes to nourish young within the female. In all live-bearers the young are born at a relatively large size and are few in number. In one family of primarily marine fishes, the surfperches from the Pacific coast of North America, Japan, and Korea, the males of at least one species are born sexually mature, although they are not fully grown.

 

Some fishes are hermaphroditic—an individual producing both sperm and eggs, usually at different stages of its life. Self-fertilization, however, is probably rare.

 

Successful reproduction and, in many cases, defense of the eggs and the young are assured by rather stereotypical but often elaborate courtship and parental behaviour, either by the male or the female or both. Some fishes prepare nests by hollowing out depressions in the sand bottom (cichlids, for example), build nests with plant materials and sticky threads excreted by the kidneys (sticklebacks), or blow a cluster of mucus-covered bubbles at the water surface (gouramis). The eggs are laid in these structures. Some varieties of cichlids and catfishes incubate eggs in their mouths.

 

Some fishes, such as salmon, undergo long migrations from the ocean and up large rivers to spawn in the gravel beds where they themselves hatched (anadromous fishes). Some, such as the freshwater eels (family Anguillidae), live and grow to maturity in fresh water and migrate to the sea to spawn (catadromous fishes). Other fishes undertake shorter migrations from lakes into streams, within the ocean, or enter spawning habitats that they do not ordinarily occupy in other ways.

 

The basic structure and function of the fish body are similar to those of all other vertebrates. The usual four types of tissues are present: surface or epithelial, connective (bone, cartilage, and fibrous tissues, as well as their derivative, blood), nerve, and muscle tissues. In addition, the fish’s organs and organ systems parallel those of other vertebrates.

 

The typical fish body is streamlined and spindle-shaped, with an anterior head, a gill apparatus, and a heart, the latter lying in the midline just below the gill chamber. The body cavity, containing the vital organs, is situated behind the head in the lower anterior part of the body. The anus usually marks the posterior termination of the body cavity and most often occurs just in front of the base of the anal fin. The spinal cord and vertebral column continue from the posterior part of the head to the base of the tail fin, passing dorsal to the body cavity and through the caudal (tail) region behind the body cavity. Most of the body is of muscular tissue, a high proportion of which is necessitated by swimming. In the course of evolution this basic body plan has been modified repeatedly into the many varieties of fish shapes that exist today.

 

The skeleton forms an integral part of the fish’s locomotion system, as well as serving to protect vital parts. The internal skeleton consists of the skull bones (except for the roofing bones of the head, which are really part of the external skeleton), the vertebral column, and the fin supports (fin rays). The fin supports are derived from the external skeleton but will be treated here because of their close functional relationship to the internal skeleton. The internal skeleton of cyclostomes, sharks, and rays is of cartilage; that of many fossil groups and some primitive living fishes is mostly of cartilage but may include some bone. In place of the vertebral column, the earliest vertebrates had a fully developed notochord, a flexible stiff rod of viscous cells surrounded by a strong fibrous sheath. During the evolution of modern fishes the rod was replaced in part by cartilage and then by ossified cartilage. Sharks and rays retain a cartilaginous vertebral column; bony fishes have spool-shaped vertebrae that in the more primitive living forms only partially replace the notochord. The skull, including the gill arches and jaws of bony fishes, is fully, or at least partially, ossified. That of sharks and rays remains cartilaginous, at times partially replaced by calcium deposits but never by true bone.

 

The supportive elements of the fins (basal or radial bones or both) have changed greatly during fish evolution. Some of these changes are described in the section below (Evolution and paleontology). Most fishes possess a single dorsal fin on the midline of the back. Many have two and a few have three dorsal fins. The other fins are the single tail and anal fins and paired pelvic and pectoral fins. A small fin, the adipose fin, with hairlike fin rays, occurs in many of the relatively primitive teleosts (such as trout) on the back near the base of the caudal fin.

 

The skin of a fish must serve many functions. It aids in maintaining the osmotic balance, provides physical protection for the body, is the site of coloration, contains sensory receptors, and, in some fishes, functions in respiration. Mucous glands, which aid in maintaining the water balance and offer protection from bacteria, are extremely numerous in fish skin, especially in cyclostomes and teleosts. Since mucous glands are present in the modern lampreys, it is reasonable to assume that they were present in primitive fishes, such as the ancient Silurian and Devonian agnathans. Protection from abrasion and predation is another function of the fish skin, and dermal (skin) bone arose early in fish evolution in response to this need. It is thought that bone first evolved in skin and only later invaded the cartilaginous areas of the fish’s body, to provide additional support and protection. There is some argument as to which came first, cartilage or bone, and fossil evidence does not settle the question. In any event, dermal bone has played an important part in fish evolution and has different characteristics in different groups of fishes. Several groups are characterized at least in part by the kind of bony scales they possess.

 

Scales have played an important part in the evolution of fishes. Primitive fishes usually had thick bony plates or thick scales in several layers of bone, enamel, and related substances. Modern teleost fishes have scales of bone, which, while still protective, allow much more freedom of motion in the body. A few modern teleosts (some catfishes, sticklebacks, and others) have secondarily acquired bony plates in the skin. Modern and early sharks possessed placoid scales, a relatively primitive type of scale with a toothlike structure, consisting of an outside layer of enamel-like substance (vitrodentine), an inner layer of dentine, and a pulp cavity containing nerves and blood vessels. Primitive bony fishes had thick scales of either the ganoid or the cosmoid type. Cosmoid scales have a hard, enamel-like outer layer, an inner layer of cosmine (a form of dentine), and then a layer of vascular bone (isopedine). In ganoid scales the hard outer layer is different chemically and is called ganoin. Under this is a cosminelike layer and then a vascular bony layer. The thin, translucent bony scales of modern fishes, called cycloid and ctenoid (the latter distinguished by serrations at the edges), lack enameloid and dentine layers.

 

Skin has several other functions in fishes. It is well supplied with nerve endings and presumably receives tactile, thermal, and pain stimuli. Skin is also well supplied with blood vessels. Some fishes breathe in part through the skin, by the exchange of oxygen and carbon dioxide between the surrounding water and numerous small blood vessels near the skin surface.

 

Skin serves as protection through the control of coloration. Fishes exhibit an almost limitless range of colours. The colours often blend closely with the surroundings, effectively hiding the animal. Many fishes use bright colours for territorial advertisement or as recognition marks for other members of their own species, or sometimes for members of other species. Many fishes can change their colour to a greater or lesser degree, by movement of pigment within the pigment cells (chromatophores). Black pigment cells (melanophores), of almost universal occurrence in fishes, are often juxtaposed with other pigment cells. When placed beneath iridocytes or leucophores (bearing the silvery or white pigment guanine), melanophores produce structural colours of blue and green. These colours are often extremely intense, because they are formed by refraction of light through the needlelike crystals of guanine. The blue and green refracted colours are often relatively pure, lacking the red and yellow rays, which have been absorbed by the black pigment (melanin) of the melanophores. Yellow, orange, and red colours are produced by erythrophores, cells containing the appropriate carotenoid pigments. Other colours are produced by combinations of melanophores, erythrophores, and iridocytes.

 

The major portion of the body of most fishes consists of muscles. Most of the mass is trunk musculature, the fin muscles usually being relatively small. The caudal fin is usually the most powerful fin, being moved by the trunk musculature. The body musculature is usually arranged in rows of chevron-shaped segments on each side. Contractions of these segments, each attached to adjacent vertebrae and vertebral processes, bends the body on the vertebral joint, producing successive undulations of the body, passing from the head to the tail, and producing driving strokes of the tail. It is the latter that provides the strong forward movement for most fishes.

 

The digestive system, in a functional sense, starts at the mouth, with the teeth used to capture prey or collect plant foods. Mouth shape and tooth structure vary greatly in fishes, depending on the kind of food normally eaten. Most fishes are predacious, feeding on small invertebrates or other fishes and have simple conical teeth on the jaws, on at least some of the bones of the roof of the mouth, and on special gill arch structures just in front of the esophagus. The latter are throat teeth. Most predacious fishes swallow their prey whole, and the teeth are used for grasping and holding prey, for orienting prey to be swallowed (head first) and for working the prey toward the esophagus. There are a variety of tooth types in fishes. Some fishes, such as sharks and piranhas, have cutting teeth for biting chunks out of their victims. A shark’s tooth, although superficially like that of a piranha, appears in many respects to be a modified scale, while that of the piranha is like that of other bony fishes, consisting of dentine and enamel. Parrot fishes have beaklike mouths with short incisor-like teeth for breaking off coral and have heavy pavementlike throat teeth for crushing the coral. Some catfishes have small brushlike teeth, arranged in rows on the jaws, for scraping plant and animal growth from rocks. Many fishes (such as the Cyprinidae or minnows) have no jaw teeth at all but have very strong throat teeth.

 

Some fishes gather planktonic food by straining it from their gill cavities with numerous elongate stiff rods (gill rakers) anchored by one end to the gill bars. The food collected on these rods is passed to the throat, where it is swallowed. Most fishes have only short gill rakers that help keep food particles from escaping out the mouth cavity into the gill chamber.

 

Once reaching the throat, food enters a short, often greatly distensible esophagus, a simple tube with a muscular wall leading into a stomach. The stomach varies greatly in fishes, depending upon the diet. In most predacious fishes it is a simple straight or curved tube or pouch with a muscular wall and a glandular lining. Food is largely digested there and leaves the stomach in liquid form.

 

Between the stomach and the intestine, ducts enter the digestive tube from the liver and pancreas. The liver is a large, clearly defined organ. The pancreas may be embedded in it, diffused through it, or broken into small parts spread along some of the intestine. The junction between the stomach and the intestine is marked by a muscular valve. Pyloric ceca (blind sacs) occur in some fishes at this junction and have a digestive or absorptive function or both.

 

The intestine itself is quite variable in length, depending upon the fish’s diet. It is short in predacious forms, sometimes no longer than the body cavity, but long in herbivorous forms, being coiled and several times longer than the entire length of the fish in some species of South American catfishes. The intestine is primarily an organ for absorbing nutrients into the bloodstream. The larger its internal surface, the greater its absorptive efficiency, and a spiral valve is one method of increasing its absorption surface.

 

Sharks, rays, chimaeras, lungfishes, surviving chondrosteans, holosteans, and even a few of the more primitive teleosts have a spiral valve or at least traces of it in the intestine. Most modern teleosts have increased the area of the intestinal walls by having numerous folds and villi (fingerlike projections) somewhat like those in humans. Undigested substances are passed to the exterior through the anus in most teleost fishes. In lungfishes, sharks, and rays, it is first passed through the cloaca, a common cavity receiving the intestinal opening and the ducts from the urogenital system.

 

Oxygen and carbon dioxide dissolve in water, and most fishes exchange dissolved oxygen and carbon dioxide in water by means of the gills. The gills lie behind and to the side of the mouth cavity and consist of fleshy filaments supported by the gill arches and filled with blood vessels, which give gills a bright red colour. Water taken in continuously through the mouth passes backward between the gill bars and over the gill filaments, where the exchange of gases takes place. The gills are protected by a gill cover in teleosts and many other fishes but by flaps of skin in sharks, rays, and some of the older fossil fish groups. The blood capillaries in the gill filaments are close to the gill surface to take up oxygen from the water and to give up excess carbon dioxide to the water.

 

Most modern fishes have a hydrostatic (ballast) organ, called the swim bladder, that lies in the body cavity just below the kidney and above the stomach and intestine. It originated as a diverticulum of the digestive canal. In advanced teleosts, especially the acanthopterygians, the bladder has lost its connection with the digestive tract, a condition called physoclistic. The connection has been retained (physostomous) by many relatively primitive teleosts. In several unrelated lines of fishes, the bladder has become specialized as a lung or, at least, as a highly vascularized accessory breathing organ. Some fishes with such accessory organs are obligate air breathers and will drown if denied access to the surface, even in well-oxygenated water. Fishes with a hydrostatic form of swim bladder can control their depth by regulating the amount of gas in the bladder. The gas, mostly oxygen, is secreted into the bladder by special glands, rendering the fish more buoyant; the gas is absorbed into the bloodstream by another special organ, reducing the overall buoyancy and allowing the fish to sink. Some deep-sea fishes may have oils, rather than gas, in the bladder. Other deep-sea and some bottom-living forms have much-reduced swim bladders or have lost the organ entirely.

 

The swim bladder of fishes follows the same developmental pattern as the lungs of land vertebrates. There is no doubt that the two structures have the same historical origin in primitive fishes. More or less intermediate forms still survive among the more primitive types of fishes, such as the lungfishes Lepidosiren and Protopterus.

 

The circulatory, or blood vascular, system consists of the heart, the arteries, the capillaries, and the veins. It is in the capillaries that the interchange of oxygen, carbon dioxide, nutrients, and other substances such as hormones and waste products takes place. The capillaries lead to the veins, which return the venous blood with its waste products to the heart, kidneys, and gills. There are two kinds of capillary beds: those in the gills and those in the rest of the body. The heart, a folded continuous muscular tube with three or four saclike enlargements, undergoes rhythmic contractions and receives venous blood in a sinus venosus. It passes the blood to an auricle and then into a thick muscular pump, the ventricle. From the ventricle the blood goes to a bulbous structure at the base of a ventral aorta just below the gills. The blood passes to the afferent (receiving) arteries of the gill arches and then to the gill capillaries. There waste gases are given off to the environment, and oxygen is absorbed. The oxygenated blood enters efferent (exuant) arteries of the gill arches and then flows into the dorsal aorta. From there blood is distributed to the tissues and organs of the body. One-way valves prevent backflow. The circulation of fishes thus differs from that of the reptiles, birds, and mammals in that oxygenated blood is not returned to the heart prior to distribution to the other parts of the body.

 

The primary excretory organ in fishes, as in other vertebrates, is the kidney. In fishes some excretion also takes place in the digestive tract, skin, and especially the gills (where ammonia is given off). Compared with land vertebrates, fishes have a special problem in maintaining their internal environment at a constant concentration of water and dissolved substances, such as salts. Proper balance of the internal environment (homeostasis) of a fish is in a great part maintained by the excretory system, especially the kidney.

 

The kidney, gills, and skin play an important role in maintaining a fish’s internal environment and checking the effects of osmosis. Marine fishes live in an environment in which the water around them has a greater concentration of salts than they can have inside their body and still maintain life. Freshwater fishes, on the other hand, live in water with a much lower concentration of salts than they require inside their bodies. Osmosis tends to promote the loss of water from the body of a marine fish and absorption of water by that of a freshwater fish. Mucus in the skin tends to slow the process but is not a sufficient barrier to prevent the movement of fluids through the permeable skin. When solutions on two sides of a permeable membrane have different concentrations of dissolved substances, water will pass through the membrane into the more concentrated solution, while the dissolved chemicals move into the area of lower concentration (diffusion).

 

The kidney of freshwater fishes is often larger in relation to body weight than that of marine fishes. In both groups the kidney excretes wastes from the body, but the kidney of freshwater fishes also excretes large amounts of water, counteracting the water absorbed through the skin. Freshwater fishes tend to lose salt to the environment and must replace it. They get some salt from their food, but the gills and skin inside the mouth actively absorb salt from water passed through the mouth. This absorption is performed by special cells capable of moving salts against the diffusion gradient. Freshwater fishes drink very little water and take in little water with their food.

 

Marine fishes must conserve water, and therefore their kidneys excrete little water. To maintain their water balance, marine fishes drink large quantities of seawater, retaining most of the water and excreting the salt. Most nitrogenous waste in marine fishes appears to be secreted by the gills as ammonia. Marine fishes can excrete salt by clusters of special cells (chloride cells) in the gills.

 

There are several teleosts—for example, the salmon—that travel between fresh water and seawater and must adjust to the reversal of osmotic gradients. They adjust their physiological processes by spending time (often surprisingly little time) in the intermediate brackish environment.

 

Marine hagfishes, sharks, and rays have osmotic concentrations in their blood about equal to that of seawater and so do not have to drink water nor perform much physiological work to maintain their osmotic balance. In sharks and rays the osmotic concentration is kept high by retention of urea in the blood. Freshwater sharks have a lowered concentration of urea in the blood.

 

Endocrine glands secrete their products into the bloodstream and body tissues and, along with the central nervous system, control and regulate many kinds of body functions. Cyclostomes have a well-developed endocrine system, and presumably it was well developed in the early Agnatha, ancestral to modern fishes. Although the endocrine system in fishes is similar to that of higher vertebrates, there are numerous differences in detail. The pituitary, the thyroid, the suprarenals, the adrenals, the pancreatic islets, the sex glands (ovaries and testes), the inner wall of the intestine, and the bodies of the ultimobranchial gland make up the endocrine system in fishes. There are some others whose function is not well understood. These organs regulate sexual activity and reproduction, growth, osmotic pressure, general metabolic activities such as the storage of fat and the utilization of foodstuffs, blood pressure, and certain aspects of skin colour. Many of these activities are also controlled in part by the central nervous system, which works with the endocrine system in maintaining the life of a fish. Some parts of the endocrine system are developmentally, and undoubtedly evolutionarily, derived from the nervous system.

 

As in all vertebrates, the nervous system of fishes is the primary mechanism coordinating body activities, as well as integrating these activities in the appropriate manner with stimuli from the environment. The central nervous system, consisting of the brain and spinal cord, is the primary integrating mechanism. The peripheral nervous system, consisting of nerves that connect the brain and spinal cord to various body organs, carries sensory information from special receptor organs such as the eyes, internal ears, nares (sense of smell), taste glands, and others to the integrating centres of the brain and spinal cord. The peripheral nervous system also carries information via different nerve cells from the integrating centres of the brain and spinal cord. This coded information is carried to the various organs and body systems, such as the skeletal muscular system, for appropriate action in response to the original external or internal stimulus. Another branch of the nervous system, the autonomic nervous system, helps to coordinate the activities of many glands and organs and is itself closely connected to the integrating centres of the brain.

 

The brain of the fish is divided into several anatomical and functional parts, all closely interconnected but each serving as the primary centre of integrating particular kinds of responses and activities. Several of these centres or parts are primarily associated with one type of sensory perception, such as sight, hearing, or smell (olfaction).

 

The sense of smell is important in almost all fishes. Certain eels with tiny eyes depend mostly on smell for location of food. The olfactory, or nasal, organ of fishes is located on the dorsal surface of the snout. The lining of the nasal organ has special sensory cells that perceive chemicals dissolved in the water, such as substances from food material, and send sensory information to the brain by way of the first cranial nerve. Odour also serves as an alarm system. Many fishes, especially various species of freshwater minnows, react with alarm to a chemical released from the skin of an injured member of their own species.

 

Many fishes have a well-developed sense of taste, and tiny pitlike taste buds or organs are located not only within their mouth cavities but also over their heads and parts of their body. Catfishes, which often have poor vision, have barbels (“whiskers”) that serve as supplementary taste organs, those around the mouth being actively used to search out food on the bottom. Some species of naturally blind cave fishes are especially well supplied with taste buds, which often cover most of their body surface.

 

Sight is extremely important in most fishes. The eye of a fish is basically like that of all other vertebrates, but the eyes of fishes are extremely varied in structure and adaptation. In general, fishes living in dark and dim water habitats have large eyes, unless they have specialized in some compensatory way so that another sense (such as smell) is dominant, in which case the eyes will often be reduced. Fishes living in brightly lighted shallow waters often will have relatively small but efficient eyes. Cyclostomes have somewhat less elaborate eyes than other fishes, with skin stretched over the eyeball perhaps making their vision somewhat less effective. Most fishes have a spherical lens and accommodate their vision to far or near subjects by moving the lens within the eyeball. A few sharks accommodate by changing the shape of the lens, as in land vertebrates. Those fishes that are heavily dependent upon the eyes have especially strong muscles for accommodation. Most fishes see well, despite the restrictions imposed by frequent turbidity of the water and by light refraction.

 

Fossil evidence suggests that colour vision evolved in fishes more than 300 million years ago, but not all living fishes have retained this ability. Experimental evidence indicates that many shallow-water fishes, if not all, have colour vision and see some colours especially well, but some bottom-dwelling shore fishes live in areas where the water is sufficiently deep to filter out most if not all colours, and these fishes apparently never see colours. When tested in shallow water, they apparently are unable to respond to colour differences.

 

Sound perception and balance are intimately associated senses in a fish. The organs of hearing are entirely internal, located within the skull, on each side of the brain and somewhat behind the eyes. Sound waves, especially those of low frequencies, travel readily through water and impinge directly upon the bones and fluids of the head and body, to be transmitted to the hearing organs. Fishes readily respond to sound; for example, a trout conditioned to escape by the approach of fishermen will take flight upon perceiving footsteps on a stream bank even if it cannot see a fisherman. Compared with humans, however, the range of sound frequencies heard by fishes is greatly restricted. Many fishes communicate with each other by producing sounds in their swim bladders, in their throats by rasping their teeth, and in other ways.

 

A fish or other vertebrate seldom has to rely on a single type of sensory information to determine the nature of the environment around it. A catfish uses taste and touch when examining a food object with its oral barbels. Like most other animals, fishes have many touch receptors over their body surface. Pain and temperature receptors also are present in fishes and presumably produce the same kind of information to a fish as to humans. Fishes react in a negative fashion to stimuli that would be painful to human beings, suggesting that they feel a sensation of pain.

 

An important sensory system in fishes that is absent in other vertebrates (except some amphibians) is the lateral line system. This consists of a series of heavily innervated small canals located in the skin and bone around the eyes, along the lower jaw, over the head, and down the mid-side of the body, where it is associated with the scales. Intermittently along these canals are located tiny sensory organs (pit organs) that apparently detect changes in pressure. The system allows a fish to sense changes in water currents and pressure, thereby helping the fish to orient itself to the various changes that occur in the physical environment.

  

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first case was identified in Wuhan, China, in December 2019. The disease has since spread worldwide, leading to an ongoing pandemic.

 

Symptoms of COVID-19 are variable, but often include fever, cough, fatigue, breathing difficulties, and loss of smell and taste. Symptoms begin one to fourteen days after exposure to the virus. Of those people who develop noticeable symptoms, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% suffer critical symptoms (respiratory failure, shock, or multiorgan dysfunction). Older people are more likely to have severe symptoms. At least a third of the people who are infected with the virus remain asymptomatic and do not develop noticeable symptoms at any point in time, but they still can spread the disease.[ Around 20% of those people will remain asymptomatic throughout infection, and the rest will develop symptoms later on, becoming pre-symptomatic rather than asymptomatic and therefore having a higher risk of transmitting the virus to others. Some people continue to experience a range of effects—known as long COVID—for months after recovery, and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease.

 

The virus that causes COVID-19 spreads mainly when an infected person is in close contact[a] with another person. Small droplets and aerosols containing the virus can spread from an infected person's nose and mouth as they breathe, cough, sneeze, sing, or speak. Other people are infected if the virus gets into their mouth, nose or eyes. The virus may also spread via contaminated surfaces, although this is not thought to be the main route of transmission. The exact route of transmission is rarely proven conclusively, but infection mainly happens when people are near each other for long enough. People who are infected can transmit the virus to another person up to two days before they themselves show symptoms, as can people who do not experience symptoms. People remain infectious for up to ten days after the onset of symptoms in moderate cases and up to 20 days in severe cases. Several testing methods have been developed to diagnose the disease. The standard diagnostic method is by detection of the virus' nucleic acid by real-time reverse transcription polymerase chain reaction (rRT-PCR), transcription-mediated amplification (TMA), or by reverse transcription loop-mediated isothermal amplification (RT-LAMP) from a nasopharyngeal swab.

 

Preventive measures include physical or social distancing, quarantining, ventilation of indoor spaces, covering coughs and sneezes, hand washing, and keeping unwashed hands away from the face. The use of face masks or coverings has been recommended in public settings to minimise the risk of transmissions. Several vaccines have been developed and several countries have initiated mass vaccination campaigns.

 

Although work is underway to develop drugs that inhibit the virus, the primary treatment is currently symptomatic. Management involves the treatment of symptoms, supportive care, isolation, and experimental measures.

 

SIGNS AND SYSTOMS

Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste, nasal congestion and rhinorrhea, cough, muscle pain, sore throat, fever, diarrhea, and breathing difficulties. People with the same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum, shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell is associated with COVID-19.

 

Most people (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging) and 5% of patients suffer critical symptoms (respiratory failure, shock, or multiorgan dysfunction). At least a third of the people who are infected with the virus do not develop noticeable symptoms at any point in time. These asymptomatic carriers tend not to get tested and can spread the disease. Other infected people will develop symptoms later, called "pre-symptomatic", or have very mild symptoms and can also spread the virus.

 

As is common with infections, there is a delay between the moment a person first becomes infected and the appearance of the first symptoms. The median delay for COVID-19 is four to five days. Most symptomatic people experience symptoms within two to seven days after exposure, and almost all will experience at least one symptom within 12 days.

Most people recover from the acute phase of the disease. However, some people continue to experience a range of effects for months after recovery—named long COVID—and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease.

 

CAUSE

TRANSMISSION

Coronavirus disease 2019 (COVID-19) spreads from person to person mainly through the respiratory route after an infected person coughs, sneezes, sings, talks or breathes. A new infection occurs when virus-containing particles exhaled by an infected person, either respiratory droplets or aerosols, get into the mouth, nose, or eyes of other people who are in close contact with the infected person. During human-to-human transmission, an average 1000 infectious SARS-CoV-2 virions are thought to initiate a new infection.

 

The closer people interact, and the longer they interact, the more likely they are to transmit COVID-19. Closer distances can involve larger droplets (which fall to the ground) and aerosols, whereas longer distances only involve aerosols. Larger droplets can also turn into aerosols (known as droplet nuclei) through evaporation. The relative importance of the larger droplets and the aerosols is not clear as of November 2020; however, the virus is not known to spread between rooms over long distances such as through air ducts. Airborne transmission is able to particularly occur indoors, in high risk locations such as restaurants, choirs, gyms, nightclubs, offices, and religious venues, often when they are crowded or less ventilated. It also occurs in healthcare settings, often when aerosol-generating medical procedures are performed on COVID-19 patients.

 

Although it is considered possible there is no direct evidence of the virus being transmitted by skin to skin contact. A person could get COVID-19 indirectly by touching a contaminated surface or object before touching their own mouth, nose, or eyes, though this is not thought to be the main way the virus spreads. The virus is not known to spread through feces, urine, breast milk, food, wastewater, drinking water, or via animal disease vectors (although some animals can contract the virus from humans). It very rarely transmits from mother to baby during pregnancy.

 

Social distancing and the wearing of cloth face masks, surgical masks, respirators, or other face coverings are controls for droplet transmission. Transmission may be decreased indoors with well maintained heating and ventilation systems to maintain good air circulation and increase the use of outdoor air.

 

The number of people generally infected by one infected person varies. Coronavirus disease 2019 is more infectious than influenza, but less so than measles. It often spreads in clusters, where infections can be traced back to an index case or geographical location. There is a major role of "super-spreading events", where many people are infected by one person.

 

A person who is infected can transmit the virus to others up to two days before they themselves show symptoms, and even if symptoms never appear. People remain infectious in moderate cases for 7–12 days, and up to two weeks in severe cases. In October 2020, medical scientists reported evidence of reinfection in one person.

 

VIROLOGY

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel severe acute respiratory syndrome coronavirus. It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan. All structural features of the novel SARS-CoV-2 virus particle occur in related coronaviruses in nature.

 

Outside the human body, the virus is destroyed by household soap, which bursts its protective bubble.

 

SARS-CoV-2 is closely related to the original SARS-CoV. It is thought to have an animal (zoonotic) origin. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus, in subgenus Sarbecovirus (lineage B) together with two bat-derived strains. It is 96% identical at the whole genome level to other bat coronavirus samples (BatCov RaTG13). The structural proteins of SARS-CoV-2 include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and the spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat SARS-CoV, maintains around 98% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only around 38% with the M protein of MERS-CoV. The structure of the M protein resembles the sugar transporter SemiSWEET.

 

The many thousands of SARS-CoV-2 variants are grouped into clades. Several different clade nomenclatures have been proposed. Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR).

 

Several notable variants of SARS-CoV-2 emerged in late 2020. Cluster 5 emerged among minks and mink farmers in Denmark. After strict quarantines and a mink euthanasia campaign, it is believed to have been eradicated. The Variant of Concern 202012/01 (VOC 202012/01) is believed to have emerged in the United Kingdom in September. The 501Y.V2 Variant, which has the same N501Y mutation, arose independently in South Africa.

 

SARS-CoV-2 VARIANTS

Three known variants of SARS-CoV-2 are currently spreading among global populations as of January 2021 including the UK Variant (referred to as B.1.1.7) first found in London and Kent, a variant discovered in South Africa (referred to as 1.351), and a variant discovered in Brazil (referred to as P.1).

 

Using Whole Genome Sequencing, epidemiology and modelling suggest the new UK variant ‘VUI – 202012/01’ (the first Variant Under Investigation in December 2020) transmits more easily than other strains.

 

PATHOPHYSIOLOGY

COVID-19 can affect the upper respiratory tract (sinuses, nose, and throat) and the lower respiratory tract (windpipe and lungs). The lungs are the organs most affected by COVID-19 because the virus accesses host cells via the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant in type II alveolar cells of the lungs. The virus uses a special surface glycoprotein called a "spike" (peplomer) to connect to ACE2 and enter the host cell. The density of ACE2 in each tissue correlates with the severity of the disease in that tissue and decreasing ACE2 activity might be protective, though another view is that increasing ACE2 using angiotensin II receptor blocker medications could be protective. As the alveolar disease progresses, respiratory failure might develop and death may follow.

 

Whether SARS-CoV-2 is able to invade the nervous system remains unknown. The virus is not detected in the CNS of the majority of COVID-19 people with neurological issues. However, SARS-CoV-2 has been detected at low levels in the brains of those who have died from COVID-19, but these results need to be confirmed. SARS-CoV-2 could cause respiratory failure through affecting the brain stem as other coronaviruses have been found to invade the CNS. While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain. The virus may also enter the bloodstream from the lungs and cross the blood-brain barrier to gain access to the CNS, possibly within an infected white blood cell.

 

The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric, duodenal and rectal epithelium as well as endothelial cells and enterocytes of the small intestine.

 

The virus can cause acute myocardial injury and chronic damage to the cardiovascular system. An acute cardiac injury was found in 12% of infected people admitted to the hospital in Wuhan, China, and is more frequent in severe disease. Rates of cardiovascular symptoms are high, owing to the systemic inflammatory response and immune system disorders during disease progression, but acute myocardial injuries may also be related to ACE2 receptors in the heart. ACE2 receptors are highly expressed in the heart and are involved in heart function. A high incidence of thrombosis and venous thromboembolism have been found people transferred to Intensive care unit (ICU) with COVID-19 infections, and may be related to poor prognosis. Blood vessel dysfunction and clot formation (as suggested by high D-dimer levels caused by blood clots) are thought to play a significant role in mortality, incidences of clots leading to pulmonary embolisms, and ischaemic events within the brain have been noted as complications leading to death in people infected with SARS-CoV-2. Infection appears to set off a chain of vasoconstrictive responses within the body, constriction of blood vessels within the pulmonary circulation has also been posited as a mechanism in which oxygenation decreases alongside the presentation of viral pneumonia. Furthermore, microvascular blood vessel damage has been reported in a small number of tissue samples of the brains – without detected SARS-CoV-2 – and the olfactory bulbs from those who have died from COVID-19.

 

Another common cause of death is complications related to the kidneys. Early reports show that up to 30% of hospitalized patients both in China and in New York have experienced some injury to their kidneys, including some persons with no previous kidney problems.

 

Autopsies of people who died of COVID-19 have found diffuse alveolar damage, and lymphocyte-containing inflammatory infiltrates within the lung.

 

IMMUNOPATHOLOGY

Although SARS-CoV-2 has a tropism for ACE2-expressing epithelial cells of the respiratory tract, people with severe COVID-19 have symptoms of systemic hyperinflammation. Clinical laboratory findings of elevated IL-2, IL-7, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-γ inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1-α (MIP-1α), and tumour necrosis factor-α (TNF-α) indicative of cytokine release syndrome (CRS) suggest an underlying immunopathology.

 

Additionally, people with COVID-19 and acute respiratory distress syndrome (ARDS) have classical serum biomarkers of CRS, including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer, and ferritin.

 

Systemic inflammation results in vasodilation, allowing inflammatory lymphocytic and monocytic infiltration of the lung and the heart. In particular, pathogenic GM-CSF-secreting T-cells were shown to correlate with the recruitment of inflammatory IL-6-secreting monocytes and severe lung pathology in people with COVID-19 . Lymphocytic infiltrates have also been reported at autopsy.

 

VIRAL AND HOST FACTORS

VIRUS PROTEINS

Multiple viral and host factors affect the pathogenesis of the virus. The S-protein, otherwise known as the spike protein, is the viral component that attaches to the host receptor via the ACE2 receptors. It includes two subunits: S1 and S2. S1 determines the virus host range and cellular tropism via the receptor binding domain. S2 mediates the membrane fusion of the virus to its potential cell host via the H1 and HR2, which are heptad repeat regions. Studies have shown that S1 domain induced IgG and IgA antibody levels at a much higher capacity. It is the focus spike proteins expression that are involved in many effective COVID-19 vaccines.

 

The M protein is the viral protein responsible for the transmembrane transport of nutrients. It is the cause of the bud release and the formation of the viral envelope. The N and E protein are accessory proteins that interfere with the host's immune response.

 

HOST FACTORS

Human angiotensin converting enzyme 2 (hACE2) is the host factor that SARS-COV2 virus targets causing COVID-19. Theoretically the usage of angiotensin receptor blockers (ARB) and ACE inhibitors upregulating ACE2 expression might increase morbidity with COVID-19, though animal data suggest some potential protective effect of ARB. However no clinical studies have proven susceptibility or outcomes. Until further data is available, guidelines and recommendations for hypertensive patients remain.

 

The virus' effect on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to a systemic inflammatory response syndrome.

 

HOST CYTOKINE RESPONSE

The severity of the inflammation can be attributed to the severity of what is known as the cytokine storm. Levels of interleukin 1B, interferon-gamma, interferon-inducible protein 10, and monocyte chemoattractant protein 1 were all associated with COVID-19 disease severity. Treatment has been proposed to combat the cytokine storm as it remains to be one of the leading causes of morbidity and mortality in COVID-19 disease.

 

A cytokine storm is due to an acute hyperinflammatory response that is responsible for clinical illness in an array of diseases but in COVID-19, it is related to worse prognosis and increased fatality. The storm causes the acute respiratory distress syndrome, blood clotting events such as strokes, myocardial infarction, encephalitis, acute kidney injury, and vasculitis. The production of IL-1, IL-2, IL-6, TNF-alpha, and interferon-gamma, all crucial components of normal immune responses, inadvertently become the causes of a cytokine storm. The cells of the central nervous system, the microglia, neurons, and astrocytes, are also be involved in the release of pro-inflammatory cytokines affecting the nervous system, and effects of cytokine storms toward the CNS are not uncommon.

 

DIAGNOSIS

COVID-19 can provisionally be diagnosed on the basis of symptoms and confirmed using reverse transcription polymerase chain reaction (RT-PCR) or other nucleic acid testing of infected secretions. Along with laboratory testing, chest CT scans may be helpful to diagnose COVID-19 in individuals with a high clinical suspicion of infection. Detection of a past infection is possible with serological tests, which detect antibodies produced by the body in response to the infection.

 

VIRAL TESTING

The standard methods of testing for presence of SARS-CoV-2 are nucleic acid tests, which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test is typically done on respiratory samples obtained by a nasopharyngeal swab; however, a nasal swab or sputum sample may also be used. Results are generally available within hours. The WHO has published several testing protocols for the disease.

 

A number of laboratories and companies have developed serological tests, which detect antibodies produced by the body in response to infection. Several have been evaluated by Public Health England and approved for use in the UK.

 

The University of Oxford's CEBM has pointed to mounting evidence that "a good proportion of 'new' mild cases and people re-testing positives after quarantine or discharge from hospital are not infectious, but are simply clearing harmless virus particles which their immune system has efficiently dealt with" and have called for "an international effort to standardize and periodically calibrate testing" On 7 September, the UK government issued "guidance for procedures to be implemented in laboratories to provide assurance of positive SARS-CoV-2 RNA results during periods of low prevalence, when there is a reduction in the predictive value of positive test results."

 

IMAGING

Chest CT scans may be helpful to diagnose COVID-19 in individuals with a high clinical suspicion of infection but are not recommended for routine screening. Bilateral multilobar ground-glass opacities with a peripheral, asymmetric, and posterior distribution are common in early infection. Subpleural dominance, crazy paving (lobular septal thickening with variable alveolar filling), and consolidation may appear as the disease progresses. Characteristic imaging features on chest radiographs and computed tomography (CT) of people who are symptomatic include asymmetric peripheral ground-glass opacities without pleural effusions.

 

Many groups have created COVID-19 datasets that include imagery such as the Italian Radiological Society which has compiled an international online database of imaging findings for confirmed cases. Due to overlap with other infections such as adenovirus, imaging without confirmation by rRT-PCR is of limited specificity in identifying COVID-19. A large study in China compared chest CT results to PCR and demonstrated that though imaging is less specific for the infection, it is faster and more sensitive.

Coding

In late 2019, the WHO assigned emergency ICD-10 disease codes U07.1 for deaths from lab-confirmed SARS-CoV-2 infection and U07.2 for deaths from clinically or epidemiologically diagnosed COVID-19 without lab-confirmed SARS-CoV-2 infection.

 

PATHOLOGY

The main pathological findings at autopsy are:

 

Macroscopy: pericarditis, lung consolidation and pulmonary oedema

Lung findings:

minor serous exudation, minor fibrin exudation

pulmonary oedema, pneumocyte hyperplasia, large atypical pneumocytes, interstitial inflammation with lymphocytic infiltration and multinucleated giant cell formation

diffuse alveolar damage (DAD) with diffuse alveolar exudates. DAD is the cause of acute respiratory distress syndrome (ARDS) and severe hypoxemia.

organisation of exudates in alveolar cavities and pulmonary interstitial fibrosis

plasmocytosis in BAL

Blood: disseminated intravascular coagulation (DIC); leukoerythroblastic reaction

Liver: microvesicular steatosis

 

PREVENTION

Preventive measures to reduce the chances of infection include staying at home, wearing a mask in public, avoiding crowded places, keeping distance from others, ventilating indoor spaces, washing hands with soap and water often and for at least 20 seconds, practising good respiratory hygiene, and avoiding touching the eyes, nose, or mouth with unwashed hands.

 

Those diagnosed with COVID-19 or who believe they may be infected are advised by the CDC to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items.

 

The first COVID-19 vaccine was granted regulatory approval on 2 December by the UK medicines regulator MHRA. It was evaluated for emergency use authorization (EUA) status by the US FDA, and in several other countries. Initially, the US National Institutes of Health guidelines do not recommend any medication for prevention of COVID-19, before or after exposure to the SARS-CoV-2 virus, outside the setting of a clinical trial. Without a vaccine, other prophylactic measures, or effective treatments, a key part of managing COVID-19 is trying to decrease and delay the epidemic peak, known as "flattening the curve". This is done by slowing the infection rate to decrease the risk of health services being overwhelmed, allowing for better treatment of current cases, and delaying additional cases until effective treatments or a vaccine become available.

 

VACCINE

A COVID‑19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus causing coronavirus disease 2019 (COVID‑19). Prior to the COVID‑19 pandemic, there was an established body of knowledge about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), which enabled accelerated development of various vaccine technologies during early 2020. On 10 January 2020, the SARS-CoV-2 genetic sequence data was shared through GISAID, and by 19 March, the global pharmaceutical industry announced a major commitment to address COVID-19.

 

In Phase III trials, several COVID‑19 vaccines have demonstrated efficacy as high as 95% in preventing symptomatic COVID‑19 infections. As of March 2021, 12 vaccines were authorized by at least one national regulatory authority for public use: two RNA vaccines (the Pfizer–BioNTech vaccine and the Moderna vaccine), four conventional inactivated vaccines (BBIBP-CorV, CoronaVac, Covaxin, and CoviVac), four viral vector vaccines (Sputnik V, the Oxford–AstraZeneca vaccine, Convidicea, and the Johnson & Johnson vaccine), and two protein subunit vaccines (EpiVacCorona and RBD-Dimer). In total, as of March 2021, 308 vaccine candidates were in various stages of development, with 73 in clinical research, including 24 in Phase I trials, 33 in Phase I–II trials, and 16 in Phase III development.

Many countries have implemented phased distribution plans that prioritize those at highest risk of complications, such as the elderly, and those at high risk of exposure and transmission, such as healthcare workers. As of 17 March 2021, 400.22 million doses of COVID‑19 vaccine have been administered worldwide based on official reports from national health agencies. AstraZeneca-Oxford anticipates producing 3 billion doses in 2021, Pfizer-BioNTech 1.3 billion doses, and Sputnik V, Sinopharm, Sinovac, and Johnson & Johnson 1 billion doses each. Moderna targets producing 600 million doses and Convidicea 500 million doses in 2021. By December 2020, more than 10 billion vaccine doses had been preordered by countries, with about half of the doses purchased by high-income countries comprising 14% of the world's population.

 

SOCIAL DISTANCING

Social distancing (also known as physical distancing) includes infection control actions intended to slow the spread of the disease by minimising close contact between individuals. Methods include quarantines; travel restrictions; and the closing of schools, workplaces, stadiums, theatres, or shopping centres. Individuals may apply social distancing methods by staying at home, limiting travel, avoiding crowded areas, using no-contact greetings, and physically distancing themselves from others. Many governments are now mandating or recommending social distancing in regions affected by the outbreak.

 

Outbreaks have occurred in prisons due to crowding and an inability to enforce adequate social distancing. In the United States, the prisoner population is aging and many of them are at high risk for poor outcomes from COVID-19 due to high rates of coexisting heart and lung disease, and poor access to high-quality healthcare.

 

SELF-ISOLATION

Self-isolation at home has been recommended for those diagnosed with COVID-19 and those who suspect they have been infected. Health agencies have issued detailed instructions for proper self-isolation. Many governments have mandated or recommended self-quarantine for entire populations. The strongest self-quarantine instructions have been issued to those in high-risk groups. Those who may have been exposed to someone with COVID-19 and those who have recently travelled to a country or region with the widespread transmission have been advised to self-quarantine for 14 days from the time of last possible exposure.

Face masks and respiratory hygiene

 

The WHO and the US CDC recommend individuals wear non-medical face coverings in public settings where there is an increased risk of transmission and where social distancing measures are difficult to maintain. This recommendation is meant to reduce the spread of the disease by asymptomatic and pre-symptomatic individuals and is complementary to established preventive measures such as social distancing. Face coverings limit the volume and travel distance of expiratory droplets dispersed when talking, breathing, and coughing. A face covering without vents or holes will also filter out particles containing the virus from inhaled and exhaled air, reducing the chances of infection. But, if the mask include an exhalation valve, a wearer that is infected (maybe without having noticed that, and asymptomatic) would transmit the virus outwards through it, despite any certification they can have. So the masks with exhalation valve are not for the infected wearers, and are not reliable to stop the pandemic in a large scale. Many countries and local jurisdictions encourage or mandate the use of face masks or cloth face coverings by members of the public to limit the spread of the virus.

 

Masks are also strongly recommended for those who may have been infected and those taking care of someone who may have the disease. When not wearing a mask, the CDC recommends covering the mouth and nose with a tissue when coughing or sneezing and recommends using the inside of the elbow if no tissue is available. Proper hand hygiene after any cough or sneeze is encouraged. Healthcare professionals interacting directly with people who have COVID-19 are advised to use respirators at least as protective as NIOSH-certified N95 or equivalent, in addition to other personal protective equipment.

 

HAND-WASHING AND HYGIENE

Thorough hand hygiene after any cough or sneeze is required. The WHO also recommends that individuals wash hands often with soap and water for at least 20 seconds, especially after going to the toilet or when hands are visibly dirty, before eating and after blowing one's nose. The CDC recommends using an alcohol-based hand sanitiser with at least 60% alcohol, but only when soap and water are not readily available. For areas where commercial hand sanitisers are not readily available, the WHO provides two formulations for local production. In these formulations, the antimicrobial activity arises from ethanol or isopropanol. Hydrogen peroxide is used to help eliminate bacterial spores in the alcohol; it is "not an active substance for hand antisepsis". Glycerol is added as a humectant.

 

SURFACE CLEANING

After being expelled from the body, coronaviruses can survive on surfaces for hours to days. If a person touches the dirty surface, they may deposit the virus at the eyes, nose, or mouth where it can enter the body cause infection. Current evidence indicates that contact with infected surfaces is not the main driver of Covid-19, leading to recommendations for optimised disinfection procedures to avoid issues such as the increase of antimicrobial resistance through the use of inappropriate cleaning products and processes. Deep cleaning and other surface sanitation has been criticized as hygiene theater, giving a false sense of security against something primarily spread through the air.

 

The amount of time that the virus can survive depends significantly on the type of surface, the temperature, and the humidity. Coronaviruses die very quickly when exposed to the UV light in sunlight. Like other enveloped viruses, SARS-CoV-2 survives longest when the temperature is at room temperature or lower, and when the relative humidity is low (<50%).

 

On many surfaces, including as glass, some types of plastic, stainless steel, and skin, the virus can remain infective for several days indoors at room temperature, or even about a week under ideal conditions. On some surfaces, including cotton fabric and copper, the virus usually dies after a few hours. As a general rule of thumb, the virus dies faster on porous surfaces than on non-porous surfaces.

However, this rule is not absolute, and of the many surfaces tested, two with the longest survival times are N95 respirator masks and surgical masks, both of which are considered porous surfaces.

 

Surfaces may be decontaminated with 62–71 percent ethanol, 50–100 percent isopropanol, 0.1 percent sodium hypochlorite, 0.5 percent hydrogen peroxide, and 0.2–7.5 percent povidone-iodine. Other solutions, such as benzalkonium chloride and chlorhexidine gluconate, are less effective. Ultraviolet germicidal irradiation may also be used. The CDC recommends that if a COVID-19 case is suspected or confirmed at a facility such as an office or day care, all areas such as offices, bathrooms, common areas, shared electronic equipment like tablets, touch screens, keyboards, remote controls, and ATM machines used by the ill persons should be disinfected. A datasheet comprising the authorised substances to disinfection in the food industry (including suspension or surface tested, kind of surface, use dilution, disinfectant and inocuylum volumes) can be seen in the supplementary material of.

 

VENTILATION AND AIR FILTRATION

The WHO recommends ventilation and air filtration in public spaces to help clear out infectious aerosols.

 

HEALTHY DIET AND LIFESTYLE

The Harvard T.H. Chan School of Public Health recommends a healthy diet, being physically active, managing psychological stress, and getting enough sleep.

 

While there is no evidence that vitamin D is an effective treatment for COVID-19, there is limited evidence that vitamin D deficiency increases the risk of severe COVID-19 symptoms. This has led to recommendations for individuals with vitamin D deficiency to take vitamin D supplements as a way of mitigating the risk of COVID-19 and other health issues associated with a possible increase in deficiency due to social distancing.

 

TREATMENT

There is no specific, effective treatment or cure for coronavirus disease 2019 (COVID-19), the disease caused by the SARS-CoV-2 virus. Thus, the cornerstone of management of COVID-19 is supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support and prone positioning as needed, and medications or devices to support other affected vital organs.

 

Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), proper intake of fluids, rest, and nasal breathing. Good personal hygiene and a healthy diet are also recommended. The U.S. Centers for Disease Control and Prevention (CDC) recommend that those who suspect they are carrying the virus isolate themselves at home and wear a face mask.

 

People with more severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is strongly recommended, as it can reduce the risk of death. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address the issue of respiratory failure, but its benefits are still under consideration.

Several experimental treatments are being actively studied in clinical trials. Others were thought to be promising early in the pandemic, such as hydroxychloroquine and lopinavir/ritonavir, but later research found them to be ineffective or even harmful. Despite ongoing research, there is still not enough high-quality evidence to recommend so-called early treatment. Nevertheless, in the United States, two monoclonal antibody-based therapies are available for early use in cases thought to be at high risk of progression to severe disease. The antiviral remdesivir is available in the U.S., Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for people needing mechanical ventilation, and is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy.

 

PROGNOSIS

The severity of COVID-19 varies. The disease may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold. In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalization. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died, the time from symptom onset to death has ranged from two to eight weeks. The Italian Istituto Superiore di Sanità reported that the median time between the onset of symptoms and death was twelve days, with seven being hospitalised. However, people transferred to an ICU had a median time of ten days between hospitalisation and death. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to ICU.

 

Some early studies suggest 10% to 20% of people with COVID-19 will experience symptoms lasting longer than a month.[191][192] A majority of those who were admitted to hospital with severe disease report long-term problems including fatigue and shortness of breath. On 30 October 2020 WHO chief Tedros Adhanom warned that "to a significant number of people, the COVID virus poses a range of serious long-term effects". He has described the vast spectrum of COVID-19 symptoms that fluctuate over time as "really concerning." They range from fatigue, a cough and shortness of breath, to inflammation and injury of major organs – including the lungs and heart, and also neurological and psychologic effects. Symptoms often overlap and can affect any system in the body. Infected people have reported cyclical bouts of fatigue, headaches, months of complete exhaustion, mood swings, and other symptoms. Tedros has concluded that therefore herd immunity is "morally unconscionable and unfeasible".

 

In terms of hospital readmissions about 9% of 106,000 individuals had to return for hospital treatment within 2 months of discharge. The average to readmit was 8 days since first hospital visit. There are several risk factors that have been identified as being a cause of multiple admissions to a hospital facility. Among these are advanced age (above 65 years of age) and presence of a chronic condition such as diabetes, COPD, heart failure or chronic kidney disease.

 

According to scientific reviews smokers are more likely to require intensive care or die compared to non-smokers, air pollution is similarly associated with risk factors, and pre-existing heart and lung diseases and also obesity contributes to an increased health risk of COVID-19.

 

It is also assumed that those that are immunocompromised are at higher risk of getting severely sick from SARS-CoV-2. One research that looked into the COVID-19 infections in hospitalized kidney transplant recipients found a mortality rate of 11%.

See also: Impact of the COVID-19 pandemic on children

 

Children make up a small proportion of reported cases, with about 1% of cases being under 10 years and 4% aged 10–19 years. They are likely to have milder symptoms and a lower chance of severe disease than adults. A European multinational study of hospitalized children published in The Lancet on 25 June 2020 found that about 8% of children admitted to a hospital needed intensive care. Four of those 582 children (0.7%) died, but the actual mortality rate could be "substantially lower" since milder cases that did not seek medical help were not included in the study.

 

Genetics also plays an important role in the ability to fight off the disease. For instance, those that do not produce detectable type I interferons or produce auto-antibodies against these may get much sicker from COVID-19. Genetic screening is able to detect interferon effector genes.

 

Pregnant women may be at higher risk of severe COVID-19 infection based on data from other similar viruses, like SARS and MERS, but data for COVID-19 is lacking.

 

COMPLICATIONS

Complications may include pneumonia, acute respiratory distress syndrome (ARDS), multi-organ failure, septic shock, and death. Cardiovascular complications may include heart failure, arrhythmias, heart inflammation, and blood clots. Approximately 20–30% of people who present with COVID-19 have elevated liver enzymes, reflecting liver injury.

 

Neurologic manifestations include seizure, stroke, encephalitis, and Guillain–Barré syndrome (which includes loss of motor functions). Following the infection, children may develop paediatric multisystem inflammatory syndrome, which has symptoms similar to Kawasaki disease, which can be fatal. In very rare cases, acute encephalopathy can occur, and it can be considered in those who have been diagnosed with COVID-19 and have an altered mental status.

 

LONGER-TERM EFFECTS

Some early studies suggest that that 10 to 20% of people with COVID-19 will experience symptoms lasting longer than a month. A majority of those who were admitted to hospital with severe disease report long-term problems, including fatigue and shortness of breath. About 5-10% of patients admitted to hospital progress to severe or critical disease, including pneumonia and acute respiratory failure.

 

By a variety of mechanisms, the lungs are the organs most affected in COVID-19.[228] The majority of CT scans performed show lung abnormalities in people tested after 28 days of illness.

 

People with advanced age, severe disease, prolonged ICU stays, or who smoke are more likely to have long lasting effects, including pulmonary fibrosis. Overall, approximately one third of those investigated after 4 weeks will have findings of pulmonary fibrosis or reduced lung function as measured by DLCO, even in people who are asymptomatic, but with the suggestion of continuing improvement with the passing of more time.

 

IMMUNITY

The immune response by humans to CoV-2 virus occurs as a combination of the cell-mediated immunity and antibody production, just as with most other infections. Since SARS-CoV-2 has been in the human population only since December 2019, it remains unknown if the immunity is long-lasting in people who recover from the disease. The presence of neutralizing antibodies in blood strongly correlates with protection from infection, but the level of neutralizing antibody declines with time. Those with asymptomatic or mild disease had undetectable levels of neutralizing antibody two months after infection. In another study, the level of neutralizing antibody fell 4-fold 1 to 4 months after the onset of symptoms. However, the lack of antibody in the blood does not mean antibody will not be rapidly produced upon reexposure to SARS-CoV-2. Memory B cells specific for the spike and nucleocapsid proteins of SARS-CoV-2 last for at least 6 months after appearance of symptoms. Nevertheless, 15 cases of reinfection with SARS-CoV-2 have been reported using stringent CDC criteria requiring identification of a different variant from the second infection. There are likely to be many more people who have been reinfected with the virus. Herd immunity will not eliminate the virus if reinfection is common. Some other coronaviruses circulating in people are capable of reinfection after roughly a year. Nonetheless, on 3 March 2021, scientists reported that a much more contagious Covid-19 variant, Lineage P.1, first detected in Japan, and subsequently found in Brazil, as well as in several places in the United States, may be associated with Covid-19 disease reinfection after recovery from an earlier Covid-19 infection.

 

MORTALITY

Several measures are commonly used to quantify mortality. These numbers vary by region and over time and are influenced by the volume of testing, healthcare system quality, treatment options, time since the initial outbreak, and population characteristics such as age, sex, and overall health. The mortality rate reflects the number of deaths within a specific demographic group divided by the population of that demographic group. Consequently, the mortality rate reflects the prevalence as well as the severity of the disease within a given population. Mortality rates are highly correlated to age, with relatively low rates for young people and relatively high rates among the elderly.

 

The case fatality rate (CFR) reflects the number of deaths divided by the number of diagnosed cases within a given time interval. Based on Johns Hopkins University statistics, the global death-to-case ratio is 2.2% (2,685,770/121,585,388) as of 18 March 2021. The number varies by region. The CFR may not reflect the true severity of the disease, because some infected individuals remain asymptomatic or experience only mild symptoms, and hence such infections may not be included in official case reports. Moreover, the CFR may vary markedly over time and across locations due to the availability of live virus tests.

 

INFECTION FATALITY RATE

A key metric in gauging the severity of COVID-19 is the infection fatality rate (IFR), also referred to as the infection fatality ratio or infection fatality risk. This metric is calculated by dividing the total number of deaths from the disease by the total number of infected individuals; hence, in contrast to the CFR, the IFR incorporates asymptomatic and undiagnosed infections as well as reported cases.

 

CURRENT ESTIMATES

A December 2020 systematic review and meta-analysis estimated that population IFR during the first wave of the pandemic was about 0.5% to 1% in many locations (including France, Netherlands, New Zealand, and Portugal), 1% to 2% in other locations (Australia, England, Lithuania, and Spain), and exceeded 2% in Italy. That study also found that most of these differences in IFR reflected corresponding differences in the age composition of the population and age-specific infection rates; in particular, the metaregression estimate of IFR is very low for children and younger adults (e.g., 0.002% at age 10 and 0.01% at age 25) but increases progressively to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85. These results were also highlighted in a December 2020 report issued by the WHO.

 

EARLIER ESTIMATES OF IFR

At an early stage of the pandemic, the World Health Organization reported estimates of IFR between 0.3% and 1%.[ On 2 July, The WHO's chief scientist reported that the average IFR estimate presented at a two-day WHO expert forum was about 0.6%. In August, the WHO found that studies incorporating data from broad serology testing in Europe showed IFR estimates converging at approximately 0.5–1%. Firm lower limits of IFRs have been established in a number of locations such as New York City and Bergamo in Italy since the IFR cannot be less than the population fatality rate. As of 10 July, in New York City, with a population of 8.4 million, 23,377 individuals (18,758 confirmed and 4,619 probable) have died with COVID-19 (0.3% of the population).Antibody testing in New York City suggested an IFR of ~0.9%,[258] and ~1.4%. In Bergamo province, 0.6% of the population has died. In September 2020 the U.S. Center for Disease Control & Prevention reported preliminary estimates of age-specific IFRs for public health planning purposes.

 

SEX DIFFERENCES

Early reviews of epidemiologic data showed gendered impact of the pandemic and a higher mortality rate in men in China and Italy. The Chinese Center for Disease Control and Prevention reported the death rate was 2.8% for men and 1.7% for women. Later reviews in June 2020 indicated that there is no significant difference in susceptibility or in CFR between genders. One review acknowledges the different mortality rates in Chinese men, suggesting that it may be attributable to lifestyle choices such as smoking and drinking alcohol rather than genetic factors. Sex-based immunological differences, lesser prevalence of smoking in women and men developing co-morbid conditions such as hypertension at a younger age than women could have contributed to the higher mortality in men. In Europe, 57% of the infected people were men and 72% of those died with COVID-19 were men. As of April 2020, the US government is not tracking sex-related data of COVID-19 infections. Research has shown that viral illnesses like Ebola, HIV, influenza and SARS affect men and women differently.

 

ETHNIC DIFFERENCES

In the US, a greater proportion of deaths due to COVID-19 have occurred among African Americans and other minority groups. Structural factors that prevent them from practicing social distancing include their concentration in crowded substandard housing and in "essential" occupations such as retail grocery workers, public transit employees, health-care workers and custodial staff. Greater prevalence of lacking health insurance and care and of underlying conditions such as diabetes, hypertension and heart disease also increase their risk of death. Similar issues affect Native American and Latino communities. According to a US health policy non-profit, 34% of American Indian and Alaska Native People (AIAN) non-elderly adults are at risk of serious illness compared to 21% of white non-elderly adults. The source attributes it to disproportionately high rates of many health conditions that may put them at higher risk as well as living conditions like lack of access to clean water. Leaders have called for efforts to research and address the disparities. In the U.K., a greater proportion of deaths due to COVID-19 have occurred in those of a Black, Asian, and other ethnic minority background. More severe impacts upon victims including the relative incidence of the necessity of hospitalization requirements, and vulnerability to the disease has been associated via DNA analysis to be expressed in genetic variants at chromosomal region 3, features that are associated with European Neanderthal heritage. That structure imposes greater risks that those affected will develop a more severe form of the disease. The findings are from Professor Svante Pääbo and researchers he leads at the Max Planck Institute for Evolutionary Anthropology and the Karolinska Institutet. This admixture of modern human and Neanderthal genes is estimated to have occurred roughly between 50,000 and 60,000 years ago in Southern Europe.

 

COMORBIDITIES

Most of those who die of COVID-19 have pre-existing (underlying) conditions, including hypertension, diabetes mellitus, and cardiovascular disease. According to March data from the United States, 89% of those hospitalised had preexisting conditions. The Italian Istituto Superiore di Sanità reported that out of 8.8% of deaths where medical charts were available, 96.1% of people had at least one comorbidity with the average person having 3.4 diseases. According to this report the most common comorbidities are hypertension (66% of deaths), type 2 diabetes (29.8% of deaths), Ischemic Heart Disease (27.6% of deaths), atrial fibrillation (23.1% of deaths) and chronic renal failure (20.2% of deaths).

 

Most critical respiratory comorbidities according to the CDC, are: moderate or severe asthma, pre-existing COPD, pulmonary fibrosis, cystic fibrosis. Evidence stemming from meta-analysis of several smaller research papers also suggests that smoking can be associated with worse outcomes. When someone with existing respiratory problems is infected with COVID-19, they might be at greater risk for severe symptoms. COVID-19 also poses a greater risk to people who misuse opioids and methamphetamines, insofar as their drug use may have caused lung damage.

 

In August 2020 the CDC issued a caution that tuberculosis infections could increase the risk of severe illness or death. The WHO recommended that people with respiratory symptoms be screened for both diseases, as testing positive for COVID-19 couldn't rule out co-infections. Some projections have estimated that reduced TB detection due to the pandemic could result in 6.3 million additional TB cases and 1.4 million TB related deaths by 2025.

 

NAME

During the initial outbreak in Wuhan, China, the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus", with the disease sometimes called "Wuhan pneumonia". In the past, many diseases have been named after geographical locations, such as the Spanish flu, Middle East Respiratory Syndrome, and Zika virus. In January 2020, the WHO recommended 2019-nCov and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 guidance and international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma. The official names COVID-19 and SARS-CoV-2 were issued by the WHO on 11 February 2020. Tedros Adhanom explained: CO for corona, VI for virus, D for disease and 19 for when the outbreak was first identified (31 December 2019). The WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications.

 

HISTORY

The virus is thought to be natural and of an animal origin, through spillover infection. There are several theories about where the first case (the so-called patient zero) originated. Phylogenetics estimates that SARS-CoV-2 arose in October or November 2019. Evidence suggests that it descends from a coronavirus that infects wild bats, and spread to humans through an intermediary wildlife host.

 

The first known human infections were in Wuhan, Hubei, China. A study of the first 41 cases of confirmed COVID-19, published in January 2020 in The Lancet, reported the earliest date of onset of symptoms as 1 December 2019.Official publications from the WHO reported the earliest onset of symptoms as 8 December 2019. Human-to-human transmission was confirmed by the WHO and Chinese authorities by 20 January 2020. According to official Chinese sources, these were mostly linked to the Huanan Seafood Wholesale Market, which also sold live animals. In May 2020 George Gao, the director of the CDC, said animal samples collected from the seafood market had tested negative for the virus, indicating that the market was the site of an early superspreading event, but that it was not the site of the initial outbreak.[ Traces of the virus have been found in wastewater samples that were collected in Milan and Turin, Italy, on 18 December 2019.

 

By December 2019, the spread of infection was almost entirely driven by human-to-human transmission. The number of coronavirus cases in Hubei gradually increased, reaching 60 by 20 December, and at least 266 by 31 December. On 24 December, Wuhan Central Hospital sent a bronchoalveolar lavage fluid (BAL) sample from an unresolved clinical case to sequencing company Vision Medicals. On 27 and 28 December, Vision Medicals informed the Wuhan Central Hospital and the Chinese CDC of the results of the test, showing a new coronavirus. A pneumonia cluster of unknown cause was observed on 26 December and treated by the doctor Zhang Jixian in Hubei Provincial Hospital, who informed the Wuhan Jianghan CDC on 27 December. On 30 December, a test report addressed to Wuhan Central Hospital, from company CapitalBio Medlab, stated an erroneous positive result for SARS, causing a group of doctors at Wuhan Central Hospital to alert their colleagues and relevant hospital authorities of the result. The Wuhan Municipal Health Commission issued a notice to various medical institutions on "the treatment of pneumonia of unknown cause" that same evening. Eight of these doctors, including Li Wenliang (punished on 3 January), were later admonished by the police for spreading false rumours and another, Ai Fen, was reprimanded by her superiors for raising the alarm.

 

The Wuhan Municipal Health Commission made the first public announcement of a pneumonia outbreak of unknown cause on 31 December, confirming 27 cases—enough to trigger an investigation.

 

During the early stages of the outbreak, the number of cases doubled approximately every seven and a half days. In early and mid-January 2020, the virus spread to other Chinese provinces, helped by the Chinese New Year migration and Wuhan being a transport hub and major rail interchange. On 20 January, China reported nearly 140 new cases in one day, including two people in Beijing and one in Shenzhen. Later official data shows 6,174 people had already developed symptoms by then, and more may have been infected. A report in The Lancet on 24 January indicated human transmission, strongly recommended personal protective equipment for health workers, and said testing for the virus was essential due to its "pandemic potential". On 30 January, the WHO declared the coronavirus a Public Health Emergency of International Concern. By this time, the outbreak spread by a factor of 100 to 200 times.

 

Italy had its first confirmed cases on 31 January 2020, two tourists from China. As of 13 March 2020 the WHO considered Europe the active centre of the pandemic. Italy overtook China as the country with the most deaths on 19 March 2020. By 26 March the United States had overtaken China and Italy with the highest number of confirmed cases in the world. Research on coronavirus genomes indicates the majority of COVID-19 cases in New York came from European travellers, rather than directly from China or any other Asian country. Retesting of prior samples found a person in France who had the virus on 27 December 2019, and a person in the United States who died from the disease on 6 February 2020.

 

After 55 days without a locally transmitted case, Beijing reported a new COVID-19 case on 11 June 2020 which was followed by two more cases on 12 June. By 15 June there were 79 cases officially confirmed, most of them were people that went to Xinfadi Wholesale Market.

 

RT-PCR testing of untreated wastewater samples from Brazil and Italy have suggested detection of SARS-CoV-2 as early as November and December 2019, respectively, but the methods of such sewage studies have not been optimised, many have not been peer reviewed, details are often missing, and there is a risk of false positives due to contamination or if only one gene target is detected. A September 2020 review journal article said, "The possibility that the COVID-19 infection had already spread to Europe at the end of last year is now indicated by abundant, even if partially circumstantial, evidence", including pneumonia case numbers and radiology in France and Italy in November and December.

 

MISINFORMATION

After the initial outbreak of COVID-19, misinformation and disinformation regarding the origin, scale, prevention, treatment, and other aspects of the disease rapidly spread online.

 

In September 2020, the U.S. CDC published preliminary estimates of the risk of death by age groups in the United States, but those estimates were widely misreported and misunderstood.

 

OTHER ANIMALS

Humans appear to be capable of spreading the virus to some other animals, a type of disease transmission referred to as zooanthroponosis.

 

Some pets, especially cats and ferrets, can catch this virus from infected humans. Symptoms in cats include respiratory (such as a cough) and digestive symptoms. Cats can spread the virus to other cats, and may be able to spread the virus to humans, but cat-to-human transmission of SARS-CoV-2 has not been proven. Compared to cats, dogs are less susceptible to this infection. Behaviors which increase the risk of transmission include kissing, licking, and petting the animal.

 

The virus does not appear to be able to infect pigs, ducks, or chickens at all.[ Mice, rats, and rabbits, if they can be infected at all, are unlikely to be involved in spreading the virus.

 

Tigers and lions in zoos have become infected as a result of contact with infected humans. As expected, monkeys and great ape species such as orangutans can also be infected with the COVID-19 virus.

 

Minks, which are in the same family as ferrets, have been infected. Minks may be asymptomatic, and can also spread the virus to humans. Multiple countries have identified infected animals in mink farms. Denmark, a major producer of mink pelts, ordered the slaughter of all minks over fears of viral mutations. A vaccine for mink and other animals is being researched.

 

RESEARCH

International research on vaccines and medicines in COVID-19 is underway by government organisations, academic groups, and industry researchers. The CDC has classified it to require a BSL3 grade laboratory. There has been a great deal of COVID-19 research, involving accelerated research processes and publishing shortcuts to meet the global demand.

 

As of December 2020, hundreds of clinical trials have been undertaken, with research happening on every continent except Antarctica. As of November 2020, more than 200 possible treatments had been studied in humans so far.

Transmission and prevention research

Modelling research has been conducted with several objectives, including predictions of the dynamics of transmission, diagnosis and prognosis of infection, estimation of the impact of interventions, or allocation of resources. Modelling studies are mostly based on epidemiological models, estimating the number of infected people over time under given conditions. Several other types of models have been developed and used during the COVID-19 including computational fluid dynamics models to study the flow physics of COVID-19, retrofits of crowd movement models to study occupant exposure, mobility-data based models to investigate transmission, or the use of macroeconomic models to assess the economic impact of the pandemic. Further, conceptual frameworks from crisis management research have been applied to better understand the effects of COVID-19 on organizations worldwide.

 

TREATMENT-RELATED RESEARCH

Repurposed antiviral drugs make up most of the research into COVID-19 treatments. Other candidates in trials include vasodilators, corticosteroids, immune therapies, lipoic acid, bevacizumab, and recombinant angiotensin-converting enzyme 2.

 

In March 2020, the World Health Organization (WHO) initiated the Solidarity trial to assess the treatment effects of some promising drugs: an experimental drug called remdesivir; anti-malarial drugs chloroquine and hydroxychloroquine; two anti-HIV drugs, lopinavir/ritonavir; and interferon-beta. More than 300 active clinical trials were underway as of April 2020.

 

Research on the antimalarial drugs hydroxychloroquine and chloroquine showed that they were ineffective at best, and that they may reduce the antiviral activity of remdesivir. By May 2020, France, Italy, and Belgium had banned the use of hydroxychloroquine as a COVID-19 treatment.

 

In June, initial results from the randomised RECOVERY Trial in the United Kingdom showed that dexamethasone reduced mortality by one third for people who are critically ill on ventilators and one fifth for those receiving supplemental oxygen. Because this is a well-tested and widely available treatment, it was welcomed by the WHO, which is in the process of updating treatment guidelines to include dexamethasone and other steroids. Based on those preliminary results, dexamethasone treatment has been recommended by the NIH for patients with COVID-19 who are mechanically ventilated or who require supplemental oxygen but not in patients with COVID-19 who do not require supplemental oxygen.

 

In September 2020, the WHO released updated guidance on using corticosteroids for COVID-19. The WHO recommends systemic corticosteroids rather than no systemic corticosteroids for the treatment of people with severe and critical COVID-19 (strong recommendation, based on moderate certainty evidence). The WHO suggests not to use corticosteroids in the treatment of people with non-severe COVID-19 (conditional recommendation, based on low certainty evidence). The updated guidance was based on a meta-analysis of clinical trials of critically ill COVID-19 patients.

 

WIKIPEDIA

Gerani (Greek: Γεράνι, literally 'Geranium', Turkish: Turnalar) is a village in the Famagusta District of Cyprus, located 8 km (5.0 mi) northeast of Trikomo. It is under the de facto control of Northern Cyprus.

 

Northern Cyprus, officially the Turkish Republic of Northern Cyprus (TRNC), is a de facto state that comprises the northeastern portion of the island of Cyprus. It is recognised only by Turkey, and its territory is considered by all other states to be part of the Republic of Cyprus.

 

Northern Cyprus extends from the tip of the Karpass Peninsula in the northeast to Morphou Bay, Cape Kormakitis and its westernmost point, the Kokkina exclave in the west. Its southernmost point is the village of Louroujina. A buffer zone under the control of the United Nations stretches between Northern Cyprus and the rest of the island and divides Nicosia, the island's largest city and capital of both sides.

 

A coup d'état in 1974, performed as part of an attempt to annex the island to Greece, prompted the Turkish invasion of Cyprus. This resulted in the eviction of much of the north's Greek Cypriot population, the flight of Turkish Cypriots from the south, and the partitioning of the island, leading to a unilateral declaration of independence by the north in 1983. Due to its lack of recognition, Northern Cyprus is heavily dependent on Turkey for economic, political and military support.

 

Attempts to reach a solution to the Cyprus dispute have been unsuccessful. The Turkish Army maintains a large force in Northern Cyprus with the support and approval of the TRNC government, while the Republic of Cyprus, the European Union as a whole, and the international community regard it as an occupation force. This military presence has been denounced in several United Nations Security Council resolutions.

 

Northern Cyprus is a semi-presidential, democratic republic with a cultural heritage incorporating various influences and an economy that is dominated by the services sector. The economy has seen growth through the 2000s and 2010s, with the GNP per capita more than tripling in the 2000s, but is held back by an international embargo due to the official closure of the ports in Northern Cyprus by the Republic of Cyprus. The official language is Turkish, with a distinct local dialect being spoken. The vast majority of the population consists of Sunni Muslims, while religious attitudes are mostly moderate and secular. Northern Cyprus is an observer state of ECO and OIC under the name "Turkish Cypriot State", PACE under the name "Turkish Cypriot Community", and Organization of Turkic States with its own name.

 

Several distinct periods of Cypriot intercommunal violence involving the two main ethnic communities, Greek Cypriots and Turkish Cypriots, marked mid-20th century Cyprus. These included the Cyprus Emergency of 1955–59 during British rule, the post-independence Cyprus crisis of 1963–64, and the Cyprus crisis of 1967. Hostilities culminated in the 1974 de facto division of the island along the Green Line following the Turkish invasion of Cyprus. The region has been relatively peaceful since then, but the Cyprus dispute has continued, with various attempts to solve it diplomatically having been generally unsuccessful.

 

Cyprus, an island lying in the eastern Mediterranean, hosted a population of Greeks and Turks (four-fifths and one-fifth, respectively), who lived under British rule in the late nineteenth-century and the first half of the twentieth-century. Christian Orthodox Church of Cyprus played a prominent political role among the Greek Cypriot community, a privilege that it acquired during the Ottoman Empire with the employment of the millet system, which gave the archbishop an unofficial ethnarch status.

 

The repeated rejections by the British of Greek Cypriot demands for enosis, union with Greece, led to armed resistance, organised by the National Organization of Cypriot Struggle, or EOKA. EOKA, led by the Greek-Cypriot commander George Grivas, systematically targeted British colonial authorities. One of the effects of EOKA's campaign was to alter the Turkish position from demanding full reincorporation into Turkey to a demand for taksim (partition). EOKA's mission and activities caused a "Cretan syndrome" (see Turkish Resistance Organisation) within the Turkish Cypriot community, as its members feared that they would be forced to leave the island in such a case as had been the case with Cretan Turks. As such, they preferred the continuation of British colonial rule and then taksim, the division of the island. Due to the Turkish Cypriots' support for the British, EOKA's leader, Georgios Grivas, declared them to be enemies. The fact that the Turks were a minority was, according to Nihat Erim, to be addressed by the transfer of thousands of Turks from mainland Turkey so that Greek Cypriots would cease to be the majority. When Erim visited Cyprus as the Turkish representative, he was advised by Field Marshal Sir John Harding, the then Governor of Cyprus, that Turkey should send educated Turks to settle in Cyprus.

 

Turkey actively promoted the idea that on the island of Cyprus two distinctive communities existed, and sidestepped its former claim that "the people of Cyprus were all Turkish subjects". In doing so, Turkey's aim to have self-determination of two to-be equal communities in effect led to de jure partition of the island.[citation needed] This could be justified to the international community against the will of the majority Greek population of the island. Dr. Fazil Küçük in 1954 had already proposed Cyprus be divided in two at the 35° parallel.

 

Lindley Dan, from Notre Dame University, spotted the roots of intercommunal violence to different visions among the two communities of Cyprus (enosis for Greek Cypriots, taksim for Turkish Cypriots). Also, Lindlay wrote that "the merging of church, schools/education, and politics in divisive and nationalistic ways" had played a crucial role in creation of havoc in Cyprus' history. Attalides Michael also pointed to the opposing nationalisms as the cause of the Cyprus problem.

 

By the mid-1950's, the "Cyprus is Turkish" party, movement, and slogan gained force in both Cyprus and Turkey. In a 1954 editorial, Turkish Cypriot leader Dr. Fazil Kuchuk expressed the sentiment that the Turkish youth had grown up with the idea that "as soon as Great Britain leaves the island, it will be taken over by the Turks", and that "Turkey cannot tolerate otherwise". This perspective contributed to the willingness of Turkish Cypriots to align themselves with the British, who started recruiting Turkish Cypriots into the police force that patrolled Cyprus to fight EOKA, a Greek Cypriot nationalist organisation that sought to rid the island of British rule.

 

EOKA targeted colonial authorities, including police, but Georgios Grivas, the leader of EOKA, did not initially wish to open up a new front by fighting Turkish Cypriots and reassured them that EOKA would not harm their people. In 1956, some Turkish Cypriot policemen were killed by EOKA members and this provoked some intercommunal violence in the spring and summer, but these attacks on policemen were not motivated by the fact that they were Turkish Cypriots.

 

However, in January 1957, Grivas changed his policy as his forces in the mountains became increasingly pressured by the British Crown forces. In order to divert the attention of the Crown forces, EOKA members started to target Turkish Cypriot policemen intentionally in the towns, so that Turkish Cypriots would riot against the Greek Cypriots and the security forces would have to be diverted to the towns to restore order. The killing of a Turkish Cypriot policeman on 19 January, when a power station was bombed, and the injury of three others, provoked three days of intercommunal violence in Nicosia. The two communities targeted each other in reprisals, at least one Greek Cypriot was killed and the British Army was deployed in the streets. Greek Cypriot stores were burned and their neighbourhoods attacked. Following the events, the Greek Cypriot leadership spread the propaganda that the riots had merely been an act of Turkish Cypriot aggression. Such events created chaos and drove the communities apart both in Cyprus and in Turkey.

 

On 22 October 1957 Sir Hugh Mackintosh Foot replaced Sir John Harding as the British Governor of Cyprus. Foot suggested five to seven years of self-government before any final decision. His plan rejected both enosis and taksim. The Turkish Cypriot response to this plan was a series of anti-British demonstrations in Nicosia on 27 and 28 January 1958 rejecting the proposed plan because the plan did not include partition. The British then withdrew the plan.

 

In 1957, Black Gang, a Turkish Cypriot pro-taksim paramilitary organisation, was formed to patrol a Turkish Cypriot enclave, the Tahtakale district of Nicosia, against activities of EOKA. The organisation later attempted to grow into a national scale, but failed to gain public support.

 

By 1958, signs of dissatisfaction with the British increased on both sides, with a group of Turkish Cypriots forming Volkan (later renamed to the Turkish Resistance Organisation) paramilitary group to promote partition and the annexation of Cyprus to Turkey as dictated by the Menderes plan. Volkan initially consisted of roughly 100 members, with the stated aim of raising awareness in Turkey of the Cyprus issue and courting military training and support for Turkish Cypriot fighters from the Turkish government.

 

In June 1958, the British Prime Minister, Harold Macmillan, was expected to propose a plan to resolve the Cyprus issue. In light of the new development, the Turks rioted in Nicosia to promote the idea that Greek and Turkish Cypriots could not live together and therefore any plan that did not include partition would not be viable. This violence was soon followed by bombing, Greek Cypriot deaths and looting of Greek Cypriot-owned shops and houses. Greek and Turkish Cypriots started to flee mixed population villages where they were a minority in search of safety. This was effectively the beginning of the segregation of the two communities. On 7 June 1958, a bomb exploded at the entrance of the Turkish Embassy in Cyprus. Following the bombing, Turkish Cypriots looted Greek Cypriot properties. On 26 June 1984, the Turkish Cypriot leader, Rauf Denktaş, admitted on British channel ITV that the bomb was placed by the Turks themselves in order to create tension. On 9 January 1995, Rauf Denktaş repeated his claim to the famous Turkish newspaper Milliyet in Turkey.

 

The crisis reached a climax on 12 June 1958, when eight Greeks, out of an armed group of thirty five arrested by soldiers of the Royal Horse Guards on suspicion of preparing an attack on the Turkish quarter of Skylloura, were killed in a suspected attack by Turkish Cypriot locals, near the village of Geunyeli, having been ordered to walk back to their village of Kondemenos.

 

After the EOKA campaign had begun, the British government successfully began to turn the Cyprus issue from a British colonial problem into a Greek-Turkish issue. British diplomacy exerted backstage influence on the Adnan Menderes government, with the aim of making Turkey active in Cyprus. For the British, the attempt had a twofold objective. The EOKA campaign would be silenced as quickly as possible, and Turkish Cypriots would not side with Greek Cypriots against the British colonial claims over the island, which would thus remain under the British. The Turkish Cypriot leadership visited Menderes to discuss the Cyprus issue. When asked how the Turkish Cypriots should respond to the Greek Cypriot claim of enosis, Menderes replied: "You should go to the British foreign minister and request the status quo be prolonged, Cyprus to remain as a British colony". When the Turkish Cypriots visited the British Foreign Secretary and requested for Cyprus to remain a colony, he replied: "You should not be asking for colonialism at this day and age, you should be asking for Cyprus be returned to Turkey, its former owner".

 

As Turkish Cypriots began to look to Turkey for protection, Greek Cypriots soon understood that enosis was extremely unlikely. The Greek Cypriot leader, Archbishop Makarios III, now set independence for the island as his objective.

 

Britain resolved to solve the dispute by creating an independent Cyprus. In 1959, all involved parties signed the Zurich Agreements: Britain, Turkey, Greece, and the Greek and Turkish Cypriot leaders, Makarios and Dr. Fazil Kucuk, respectively. The new constitution drew heavily on the ethnic composition of the island. The President would be a Greek Cypriot, and the Vice-President a Turkish Cypriot with an equal veto. The contribution to the public service would be set at a ratio of 70:30, and the Supreme Court would consist of an equal number of judges from both communities as well as an independent judge who was not Greek, Turkish or British. The Zurich Agreements were supplemented by a number of treaties. The Treaty of Guarantee stated that secession or union with any state was forbidden, and that Greece, Turkey and Britain would be given guarantor status to intervene if that was violated. The Treaty of Alliance allowed for two small Greek and Turkish military contingents to be stationed on the island, and the Treaty of Establishment gave Britain sovereignty over two bases in Akrotiri and Dhekelia.

 

On 15 August 1960, the Colony of Cyprus became fully independent as the Republic of Cyprus. The new republic remained within the Commonwealth of Nations.

 

The new constitution brought dissatisfaction to Greek Cypriots, who felt it to be highly unjust for them for historical, demographic and contributional reasons. Although 80% of the island's population were Greek Cypriots and these indigenous people had lived on the island for thousands of years and paid 94% of taxes, the new constitution was giving the 17% of the population that was Turkish Cypriots, who paid 6% of taxes, around 30% of government jobs and 40% of national security jobs.

 

Within three years tensions between the two communities in administrative affairs began to show. In particular disputes over separate municipalities and taxation created a deadlock in government. A constitutional court ruled in 1963 Makarios had failed to uphold article 173 of the constitution which called for the establishment of separate municipalities for Turkish Cypriots. Makarios subsequently declared his intention to ignore the judgement, resulting in the West German judge resigning from his position. Makarios proposed thirteen amendments to the constitution, which would have had the effect of resolving most of the issues in the Greek Cypriot favour. Under the proposals, the President and Vice-President would lose their veto, the separate municipalities as sought after by the Turkish Cypriots would be abandoned, the need for separate majorities by both communities in passing legislation would be discarded and the civil service contribution would be set at actual population ratios (82:18) instead of the slightly higher figure for Turkish Cypriots.

 

The intention behind the amendments has long been called into question. The Akritas plan, written in the height of the constitutional dispute by the Greek Cypriot interior minister Polycarpos Georkadjis, called for the removal of undesirable elements of the constitution so as to allow power-sharing to work. The plan envisaged a swift retaliatory attack on Turkish Cypriot strongholds should Turkish Cypriots resort to violence to resist the measures, stating "In the event of a planned or staged Turkish attack, it is imperative to overcome it by force in the shortest possible time, because if we succeed in gaining command of the situation (in one or two days), no outside, intervention would be either justified or possible." Whether Makarios's proposals were part of the Akritas plan is unclear, however it remains that sentiment towards enosis had not completely disappeared with independence. Makarios described independence as "a step on the road to enosis".[31] Preparations for conflict were not entirely absent from Turkish Cypriots either, with right wing elements still believing taksim (partition) the best safeguard against enosis.

 

Greek Cypriots however believe the amendments were a necessity stemming from a perceived attempt by Turkish Cypriots to frustrate the working of government. Turkish Cypriots saw it as a means to reduce their status within the state from one of co-founder to that of minority, seeing it as a first step towards enosis. The security situation deteriorated rapidly.

 

Main articles: Bloody Christmas (1963) and Battle of Tillyria

An armed conflict was triggered after December 21, 1963, a period remembered by Turkish Cypriots as Bloody Christmas, when a Greek Cypriot policemen that had been called to help deal with a taxi driver refusing officers already on the scene access to check the identification documents of his customers, took out his gun upon arrival and shot and killed the taxi driver and his partner. Eric Solsten summarised the events as follows: "a Greek Cypriot police patrol, ostensibly checking identification documents, stopped a Turkish Cypriot couple on the edge of the Turkish quarter. A hostile crowd gathered, shots were fired, and two Turkish Cypriots were killed."

 

In the morning after the shooting, crowds gathered in protest in Northern Nicosia, likely encouraged by the TMT, without incident. On the evening of the 22nd, gunfire broke out, communication lines to the Turkish neighbourhoods were cut, and the Greek Cypriot police occupied the nearby airport. On the 23rd, a ceasefire was negotiated, but did not hold. Fighting, including automatic weapons fire, between Greek and Turkish Cypriots and militias increased in Nicosia and Larnaca. A force of Greek Cypriot irregulars led by Nikos Sampson entered the Nicosia suburb of Omorphita and engaged in heavy firing on armed, as well as by some accounts unarmed, Turkish Cypriots. The Omorphita clash has been described by Turkish Cypriots as a massacre, while this view has generally not been acknowledged by Greek Cypriots.

 

Further ceasefires were arranged between the two sides, but also failed. By Christmas Eve, the 24th, Britain, Greece, and Turkey had joined talks, with all sides calling for a truce. On Christmas day, Turkish fighter jets overflew Nicosia in a show of support. Finally it was agreed to allow a force of 2,700 British soldiers to help enforce a ceasefire. In the next days, a "buffer zone" was created in Nicosia, and a British officer marked a line on a map with green ink, separating the two sides of the city, which was the beginning of the "Green Line". Fighting continued across the island for the next several weeks.

 

In total 364 Turkish Cypriots and 174 Greek Cypriots were killed during the violence. 25,000 Turkish Cypriots from 103-109 villages fled and were displaced into enclaves and thousands of Turkish Cypriot houses were ransacked or completely destroyed.

 

Contemporary newspapers also reported on the forceful exodus of the Turkish Cypriots from their homes. According to The Times in 1964, threats, shootings and attempts of arson were committed against the Turkish Cypriots to force them out of their homes. The Daily Express wrote that "25,000 Turks have already been forced to leave their homes". The Guardian reported a massacre of Turks at Limassol on 16 February 1964.

 

Turkey had by now readied its fleet and its fighter jets appeared over Nicosia. Turkey was dissuaded from direct involvement by the creation of a United Nations Peacekeeping Force in Cyprus (UNFICYP) in 1964. Despite the negotiated ceasefire in Nicosia, attacks on the Turkish Cypriot persisted, particularly in Limassol. Concerned about the possibility of a Turkish invasion, Makarios undertook the creation of a Greek Cypriot conscript-based army called the "National Guard". A general from Greece took charge of the army, whilst a further 20,000 well-equipped officers and men were smuggled from Greece into Cyprus. Turkey threatened to intervene once more, but was prevented by a strongly worded letter from the American President Lyndon B. Johnson, anxious to avoid a conflict between NATO allies Greece and Turkey at the height of the Cold War.

 

Turkish Cypriots had by now established an important bridgehead at Kokkina, provided with arms, volunteers and materials from Turkey and abroad. Seeing this incursion of foreign weapons and troops as a major threat, the Cypriot government invited George Grivas to return from Greece as commander of the Greek troops on the island and launch a major attack on the bridgehead. Turkey retaliated by dispatching its fighter jets to bomb Greek positions, causing Makarios to threaten an attack on every Turkish Cypriot village on the island if the bombings did not cease. The conflict had now drawn in Greece and Turkey, with both countries amassing troops on their Thracian borders. Efforts at mediation by Dean Acheson, a former U.S. Secretary of State, and UN-appointed mediator Galo Plaza had failed, all the while the division of the two communities becoming more apparent. Greek Cypriot forces were estimated at some 30,000, including the National Guard and the large contingent from Greece. Defending the Turkish Cypriot enclaves was a force of approximately 5,000 irregulars, led by a Turkish colonel, but lacking the equipment and organisation of the Greek forces.

 

The Secretary-General of the United Nations in 1964, U Thant, reported the damage during the conflicts:

 

UNFICYP carried out a detailed survey of all damage to properties throughout the island during the disturbances; it shows that in 109 villages, most of them Turkish-Cypriot or mixed villages, 527 houses have been destroyed while 2,000 others have suffered damage from looting.

 

The situation worsened in 1967, when a military junta overthrew the democratically elected government of Greece, and began applying pressure on Makarios to achieve enosis. Makarios, not wishing to become part of a military dictatorship or trigger a Turkish invasion, began to distance himself from the goal of enosis. This caused tensions with the junta in Greece as well as George Grivas in Cyprus. Grivas's control over the National Guard and Greek contingent was seen as a threat to Makarios's position, who now feared a possible coup.[citation needed] The National Guard and Cyprus Police began patrolling the Turkish Cypriot enclaves of Ayios Theodoros and Kophinou, and on November 15 engaged in heavy fighting with the Turkish Cypriots.

 

By the time of his withdrawal 26 Turkish Cypriots had been killed. Turkey replied with an ultimatum demanding that Grivas be removed from the island, that the troops smuggled from Greece in excess of the limits of the Treaty of Alliance be removed, and that the economic blockades on the Turkish Cypriot enclaves be lifted. Grivas was recalled by the Athens Junta and the 12,000 Greek troops were withdrawn. Makarios now attempted to consolidate his position by reducing the number of National Guard troops, and by creating a paramilitary force loyal to Cypriot independence. In 1968, acknowledging that enosis was now all but impossible, Makarios stated, "A solution by necessity must be sought within the limits of what is feasible which does not always coincide with the limits of what is desirable."

 

After 1967 tensions between the Greek and Turkish Cypriots subsided. Instead, the main source of tension on the island came from factions within the Greek Cypriot community. Although Makarios had effectively abandoned enosis in favour of an 'attainable solution', many others continued to believe that the only legitimate political aspiration for Greek Cypriots was union with Greece.

 

On his arrival, Grivas began by establishing a nationalist paramilitary group known as the National Organization of Cypriot Fighters (Ethniki Organosis Kyprion Agoniston B or EOKA-B), drawing comparisons with the EOKA struggle for enosis under the British colonial administration of the 1950s.

 

The military junta in Athens saw Makarios as an obstacle. Makarios's failure to disband the National Guard, whose officer class was dominated by mainland Greeks, had meant the junta had practical control over the Cypriot military establishment, leaving Makarios isolated and a vulnerable target.

 

During the first Turkish invasion, Turkish troops invaded Cyprus territory on 20 July 1974, invoking its rights under the Treaty of Guarantee. This expansion of Turkish-occupied zone violated International Law as well as the Charter of the United Nations. Turkish troops managed to capture 3% of the island which was accompanied by the burning of the Turkish Cypriot quarter, as well as the raping and killing of women and children. A temporary cease-fire followed which was mitigated by the UN Security Council. Subsequently, the Greek military Junta collapsed on July 23, 1974, and peace talks commenced in which a democratic government was installed. The Resolution 353 was broken after Turkey attacked a second time and managed to get a hold of 37% of Cyprus territory. The Island of Cyprus was appointed a Buffer Zone by the United Nations, which divided the island into two zones through the 'Green Line' and put an end to the Turkish invasion. Although Turkey announced that the occupied areas of Cyprus to be called the Federated Turkish State in 1975, it is not legitimised on a worldwide political scale. The United Nations called for the international recognition of independence for the Republic of Cyprus in the Security Council Resolution 367.

 

In the years after the Turkish invasion of northern Cyprus one can observe a history of failed talks between the two parties. The 1983 declaration of the independent Turkish Republic of Cyprus resulted in a rise of inter-communal tensions and made it increasingly hard to find mutual understanding. With Cyprus' interest of a possible EU membership and a new UN Secretary-General Kofi Annan in 1997 new hopes arose for a fresh start. International involvement from sides of the US and UK, wanting a solution to the Cyprus dispute prior to the EU accession led to political pressures for new talks. The believe that an accession without a solution would threaten Greek-Turkish relations and acknowledge the partition of the island would direct the coming negotiations.

 

Over the course of two years a concrete plan, the Annan plan was formulated. In 2004 the fifth version agreed upon from both sides and with the endorsement of Turkey, US, UK and EU then was presented to the public and was given a referendum in both Cypriot communities to assure the legitimisation of the resolution. The Turkish Cypriots voted with 65% for the plan, however the Greek Cypriots voted with a 76% majority against. The Annan plan contained multiple important topics. Firstly it established a confederation of two separate states called the United Cyprus Republic. Both communities would have autonomous states combined under one unified government. The members of parliament would be chosen according to the percentage in population numbers to ensure a just involvement from both communities. The paper proposed a demilitarisation of the island over the next years. Furthermore it agreed upon a number of 45000 Turkish settlers that could remain on the island. These settlers became a very important issue concerning peace talks. Originally the Turkish government encouraged Turks to settle in Cyprus providing transfer and property, to establish a counterpart to the Greek Cypriot population due to their 1 to 5 minority. With the economic situation many Turkish-Cypriot decided to leave the island, however their departure is made up by incoming Turkish settlers leaving the population ratio between Turkish Cypriots and Greek Cypriots stable. However all these points where criticised and as seen in the vote rejected mainly by the Greek Cypriots. These name the dissolution of the „Republic of Cyprus", economic consequences of a reunion and the remaining Turkish settlers as reason. Many claim that the plan was indeed drawing more from Turkish-Cypriot demands then Greek-Cypriot interests. Taking in consideration that the US wanted to keep Turkey as a strategic partner in future Middle Eastern conflicts.

 

A week after the failed referendum the Republic of Cyprus joined the EU. In multiple instances the EU tried to promote trade with Northern Cyprus but without internationally recognised ports this spiked a grand debate. Both side endure their intention of negotiations, however without the prospect of any new compromises or agreements the UN is unwilling to start the process again. Since 2004 negotiations took place in numbers but without any results, both sides are strongly holding on to their position without an agreeable solution in sight that would suit both parties.

NASA Acting Chief Technologist Douglas Terrier, left, moderates a panel discussion titled The Big Picture with NASA James Webb Space Telescope systems engineer Mike Menzel, SpaceX Director of space operations and former NASA astronaut Garret Reisman, Honeybee Robotics co-founder and chairman Stephen Gorevan, and former NASA astronaut Mike Massimino, Saturday, Aug. 5, 2017 at the Intrepid Sea, Air & Space Museum in New York City. Photo Credit: (NASA/Bill Ingalls)

X-RATED BEARRISON FAIR 2025 ! ! ~

BEARRISON 2025 ~ BEARMAN FAIR 2025 !

photographed by ADDA DADA ! ~

• 🔹• 🔹•🔹• •🔹•• 🔹• 🔹•🔹•

 

THANK YOU for the 805 MILLION VIEWS ! ~

 

ADDA DADA's VIEW COUNT is :

EIGHT HUNDRED FIVE MILLION VIEWS ! ~

805,000,000+ VIEWS with over 18,200+ followers !

( October 8, 2025 ! )

 

THANKS for the 805 MILLION VIEWS !

 

🔹•🔹• 🔹•🔹• •🔹••🔹••••🔹• •🔹

🔹•🔹• 🔹•🔹• •🔹••🔹••••🔹• •🔹

 

•🔹•THANK YOU for visiting my virtual art gallery! Enjoy my 'social documentary' photographs of various events !

•🔹•

•🔹• ADDA DADA's photography presents a variety of adults (18+ years old) at different public events . These photographs do NOT imply the person's sexual orientation in any way. Everyone was asked and they consented to be photographed and posted .

•🔹•.

•.🔹•NUDE/18+ photographs are properly marked MODERATE or RESTRICTED ! SAFE photographs do NOT show nudity nor sexual situations.

--------

•.🔹•Viewers should be aware that these photographs are viewed by a wide variety of people . Inappropriate, negative, RUDE, 'X' or 'R' rated comments shall be removed forthwith & you will be blocked.

•🔹•

•🔹•.MY photographs are NOT to be reproduced, COPIED, BLOGGED, USED in any way shape or form !

© All rights reserved. Use without permission is illegal.

•🔹•

Check out ADDA DADA's other ALBUMS•

🔹 • 🔹• 🔹• 🔹•🔹• •🔹•• 🔹•🔹• •🔹••

    

Erica Greider moderates the discussion "Is the President Right About the Dream Act?" with state representatives Joaquin Castro, D-San Antonio, Raul Torres, R-Corpus Christi, and Ana Hernandez Luna, D-Houston, and former vice president of communications at TPPF Joshua Treviño at The Texas Tribune Festival on Sept. 22, 2012. (Photo by Spencer Selvidge)

Carolee Schneemann

"Scroll Box - The Cave

Original scroll from group event at Widow Jane Cave in Rosendale, NY"

1995

laminated paper scroll, suspended in aluminum case designed by the artist

24 x 4 x 4 inches

61 x 10.2 x 10.2 cm

  

www.davidnolangallery.com/exhibitions/2010-01-28_the-visi...

 

THE VISIBLE VAGINA

 

January 28 – March 20, 2010

 

With

FRANCIS M. NAUMANN FINE ART

 

Opening receptions:

 

Wednesday, January 27, 6-8 pm at Francis Naumann Fine Art

 

Thursday, January 28, 6-8 pm at David Nolan Gallery

 

Featuring works by: Magdalena Abakanowicz, Beth B, Judie Bamber, Tracey Baran, Nancy Becker, Hans Bellmer, Mike Bidlo, Robert Brinker, Judy Chicago, Carol Cole, Maureen Connor, Tee Corinne, John Currin, Sarah Davis, D. James Dee, Marcel Duchamp, Carroll Dunham, India Evans, John Evans, Robert Forman, Neil Gall, Kathleen Gilje, Guerrilla Girls, Nancy Grossman, Barbara Hammer, Jane Hammond, Stanley William Hayter, Sandra Vásquez de la Horra, David Humphrey, Paul Joostens, Pamela Joseph, Mel Kendrick, Elisabeth Kley, Jeff Koons, Mark Kostabi, Sherrie Levine, Henri Maccheroni, Chema Madoz, Gerard Malanga, Man Ray, Robert Mapplethorpe, Marcel Mariën, André Masson, Sophie Matisse, Ana Mendieta, Allyson Mitchell, Cathy de Monchaux, Wangechi Mutu, Gladys Nilsson, Yoko Ono, Pablo Picasso, Chloe Piene, Richard Prince, Daniel Ranalli, Oona Ratcliffe, Katia Santibanez, Peter Saul, Naomi Savage, Carolee Schneemann, Mira Schor, Michelle Segre, Tom Shannon, James Siena, Laurie Simmons, Kiki Smith, Nancy Spero, Betty Tompkins, Kiyoshi Tsuchiya, John Tweddle, Tabitha Vevers, Douglas Vogel, Robert Watts, Hannah Wilke, Terry Winters, and Beatrice Wood.

 

THE VISIBLE VAGINA is an exhibition jointly organized by Francis M. Naumann and David Nolan. It is scheduled to open at Francis M. Naumann Fine Art (24 West 57th Street) and at David Nolan Gallery (527 West 29th Street) on January 28, 2010. Both shows will run concurrently, ending on March 20, 2010.

 

As the title of the exhibition suggests, the show is designed to make visible a portion of the female anatomy that is generally considered taboo―too private and intimate for public display. If shown at all, this part of a woman's body is usually presented in an abject fashion, generally within the context of pornography, intended, in almost all cases, for the exclusive pleasure of men. The goal of this exhibition is to remove these prurient connotations, implicit even in works of art, ever since the pudendum was prudishly covered by a fig leaf. This gesture of false modesty, it should be noted, was devised and enforced entirely by men (not only in the case of classical sculpture, but also in the Bible, in which, immediately after their disobedience in the Garden of Eden, Adam and Eve cover their genitalia with fig leaves). Indeed, until recently, men made virtually all depictions of the frontal nude female figure, but as this exhibition will demonstrate, that has changed dramatically in recent years.

 

The catalogue for THE VISIBLE VAGINA will trace this motif in art history from prehistoric to modern times. It includes an introduction by the exhibition organizers, as well as a highly informative and provocative essay by Anna C. Chave, Professor of Contemporary Art and Theory at the Graduate Center of the City University of New York. Inspiration for both the show and its catalogue came from Eve Ensler's The Vagina Monologues, a stage play that premiered off-Broadway in 1996, and was followed by various productions throughout the world (it appeared as a book in 1998). Ensler gave voice to countless women worldwide, honoring the complexity and mystery of their sexuality, basically encouraging them to consider their vaginas as powerful and expressive components of their physical selves, something not to be ashamed of, but to be proudly protected as an assertive and positive manifestation of their being. The idea for this show came from realizing that there was no better group to give vision to this goal than artists, many of whom had already incorporated imagery of the vagina in their works. Because of Ensler's pioneering work in this field, the catalogue is dedicated to her, and proceeds from its sale shall be donated to V-Day, the organization she founded to end violence against women and girls throughout the world. Price: $27.50.

 

EVENT

Panel discussion with artists in the exhibition, moderated by Anna Chave, will take place on Saturday, January 30, from 2-4 pm at David Nolan Gallery. We hope you will be able to join us.

 

###

Media Contact:

For further information, images or to arrange for an interview, please contact:

Katherine Chan, Director

T: 212-925-6190 F: 212-334-9139

katherine@davidnolangallery.com

 

David Nolan New York

527 West 29th Street

New York, NY 10001

T +1 212 925 6190

F +1 212 334 9139

www.davidnolangallery.com

For someone like me, who has lived in a moderate climatic zone for all his life, sand has it's very own fascination. From my website at www.focx.de

The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument on NASA's Aqua satellite captured this image of cloud streets and sea ice in the Sea of Okhotsk on Feb. 8, 2016. Cloud streets are long parallel bands of cumulus clouds that form when cold air blows over warmer waters and a warmer air layer rests over the top of both. via NASA ift.tt/1osc2Tu

©AVucha 2017

Dozens of homes sustained moderate to heavy damage early Sunday morning after a home exploded in Marengo. The blast occurred shortly before 5 a.m. in the 500 block of 7th Circle, setting fire to at least two neighboring homes. According to officials, four people were rescued from the second floor of a house next door. There were no reports of serious injuries. Neighbors say the family who live in the home where the blast occurred are currently on vacation. While the investigation is underway, it’s believed a gas leak caused the explosion.

  

This photograph is being made available only for personal use printing by the subject(s) of the photograph. The photograph may not be manipulated in any way and may not be used in commercial material, advertisements, emails, products, promotions without the expressed consent of Alex Vucha.

 

Moderate rent, well connected, weather proof

LBA as of 2017/07/29

Previous LBA Family Portrait from 2016/04/29

 

Rest in Peace Wallet™

 

By this time I have acquired the great VS1 trio, with the 28mm f/1.9 still on the hitlist. I've also acquired the M4/3 cult classic Navitar 75mm f/1.3, as well as the silver version of the Carl Zeiss Jena Tessar 50mm f/2.8

 

・Konica Hexanon AR 135mm f/3.5

・Vivitar (Komine) Series 1 VMC 200mm f/3 in Minolta MD/SR

・Vivitar (Komine) Series 1 135mm f/2.3 in Canon FD

・Vivitar (Tokina) Series 1 VMC Macro 90mm f/2.5 "Bokina" with Macro Adapter in Minolta MD/SR

・Vivitar (Komine) Auto Telephoto Macro 90mm f/2.8 in M42

・Navitar TV Lens 75mm f/1.3 in C-Mount

・Helios 44-2 in M42

・Minolta Auto Rokkor-PF 58mm f/1.4

・Minolta MC Rokkor-PF 58mm f/1.4

・Konica Hexanon 57mm f/1.4

・Konica Macro-Hexanon AR 55mm f/3.5 with Adapter

・Konica Hexanon AR 50mm f/1.8

・Canon FD 50mm f/1.8

・Carl Zeiss Jena Tessar 50mm f/2.8 in M42

・Minolta MD Rokkor-X 45mm f/2

・Vivitar (Tokina) Auto Wide-Angle 35mm f/2.8 in Minolta MD

・Tokina RMC 28mm f/2.8 in Minolta MD

・Vivitar (Komine) 28mm f/2.8 in Minolta MD

・Auto Vivitar Wide-Angle 28mm f/2.5 in Minolta SR

・Junky Sony Kit Lens :)

 

Taken with EF-M22mm f/2 STM on Canon EOS M

Visit this location at Crumbi (72,16) Moderate 1536m in Second Life

Moderate to heavy rain along with gusty southerly winds have battered the region this evening as another potent, strong storm system pushes thru...

 

Weather scenario & details:

It was a rainy, stormy, unsettled Sunday evening here in San Jose, CA. We already had a previous storm pound us with heavy rain and strong winds. This was a 2nd storm...and this 2nd one seemed a tad stronger than the last! Talk about a 'Miracle March'! More storm advisories were posted for the region due to the stormy weather. Certainly, all this rainfall was thanks to an ongoing atmospheric river event. The moisture and storminess from this atmospheric river event was to continue at least until Monday (March 7) or so...

 

Timing of the storms: The 1st storm had hit by the 1st weekend of the month, bringing heavy rain & gusty winds to our area. As we started the 2nd week, a 2nd strong(er) storm system was threatening to trigger more flooding, mudslides and treacherous traveling conditions across California. On the heels of the 1st storm, this 2nd storm was to push more stormy weather across the state. Rainfall from this 2nd storm would roughly be 1-2 inches in NorCal. Flash flooding was a concern, especially with the ground already saturated and streams running high from the 1st storm. While all this rain was to help put a dent in our drought, the copious amounts of rain falling in a short time was too much of a good thing... Looks like this was El Nino's last hurrah this winter!

 

(Filmed Sunday late evening, March 6, 2016 around San Jose, CA)

President George W. Bush moderates a conversation with General Peter Chiarelli, USMC Veteran Brian Stann and USMC Veteran Dave Smith on veteran transition. bit.ly/1LaBscu

 

Photo by Grant Miller for the George W. Bush Presidential Center

Moderate to heavy rain and wind batter the Bay Area this evening.

 

Weather scenario & details:

Indeed, it was a rainy, stormy, unsettled Sunday evening here in San Jose, CA. We already had a previous storm pound us with heavy rain and strong winds. This was a 2nd storm...and this 2nd one seemed a tad stronger than the last! Talk about a 'Miracle March'! More storm advisories were posted for the region due to the stormy weather. Certainly, all this rainfall was thanks to an ongoing atmospheric river event. The moisture and storminess from this atmospheric river event was to continue at least until Monday (March 7) or so...

 

Timing of the storms: The 1st storm had hit by the 1st weekend of the month, bringing heavy rain & gusty winds to our area. As we started the 2nd week, a 2nd strong(er) storm system was threatening to trigger more flooding, mudslides and treacherous traveling conditions across California. On the heels of the 1st storm, this 2nd storm was to push more stormy weather across the state. Rainfall from this 2nd storm would roughly be 1-2 inches in NorCal. Flash flooding was a concern, especially with the ground already saturated and streams running high from the 1st storm. While all this rain was to help put a dent in our drought, the copious amounts of rain falling in a short time was too much of a good thing... Looks like this was El Nino's last hurrah this winter!

 

(Filmed Sunday late evening, March 6, 2016 around San Jose, CA)

NASA Headquarters Public Affairs Officer Dwayne Brown moderates a Lunar Atmosphere and Dust Environment Explorer (LADEE) mission briefing at NASA Headquarters, Thursday, August 22, 2013 in Washington. Data from NASA's LADEE mission will provide unprecedented information about the environment around the moon and give scientists a better understanding of other planetary bodies in our solar system and beyond. The LADEE mission is scheduled to launch at 11:27 p.m. Friday, Sept. 6, from NASA's Wallops Flight Facility on Wallops Island, Va. Photo Credit: (NASA/Bill Ingalls)

Moderated by

Bob Schieffer

Chief Washington Correspondent, CBS News;

Anchor, CBS News’ “Face the Nation”

Panelists:

-Thomas L. Friedman

Pulitzer Prize–winning Author and Columnist, New York Times

-Margaret Brennan

State Department Correspondent, CBS News

-Gerald F. Seib

Washington Bureau Chief, The Wall Street Journal

Author, Capitol Journal columnist

The Center for Strategic and International Studies (CSIS) and TCU’s Schieffer School of Journalism invite you to the next session of The CSIS-Schieffer Series Dialogues

Made possible with support from the Stavros Niarchos Foundation

on

Foreign Policy Challenges for President Obama’s Second Term

  

Coll Misc 0840-21a

 

A workman looks at two posters on the wall. One recounts of the beneficial policies of the Progressive Party, the other the problems of the Moderate Party.

This is interesting.

 

A while back, I made any photos that show boobs or butt or whatever friends + family. Mainly because I don't want my family or Dave's family to see them. They likely would not go to the trouble of creating a Flickr account, but would browse our streams.

 

I then realized none of them were 'moderate', or very few. So I am trying to mark them all as such and now debating if I should still have them as F+F. I guess it doesn't matter...I mean it *IS* kinda fun to see I have a photo with 25,000+ views, even if it IS of my boobs and not something I would consider quality.

 

Now here is the weird part: ever since restricting them, when I go to Scout, it shows all the restricted ones as 'not available'. There is still a spot for them but you can't *see* the photo.

 

But I just made this and here they all are! *I* can see them all now.

 

If you are not a Friend or Family, can you let me know if you can see them? Are there any blocked to you?

 

1. 290/365: Think of Tomorrow., 2. 289/365: Taken for mom, and got lazy., 3. 288/365: For Jessi, and Foot-Fetishers Everywhere, 4. 283/365: Preoccupied, Pondering, Plotting...Propitious?, 5. First Date, 6. Peek-a-boo, 7. untitled., 8. 270/365: Revelations.,

 

9. 266/365: Moment of quiet., 10. 11.01.07 - 257/365: Taking a break, 11. 256/365: The part George Lucas cut out of the film, 12. 252/365: No matter how the day goes..., 13. Rusty, 14. 248/365: I got nothin', 15. 247/365: My other obsession, 16. We woke up to snow!,

 

17. 245/365: I love fall..., 18. 244/365: Headache., 19. 242/365: Get it off!, 20. 241/365: Sock Dreams, 21. Color., 22. 230/365: A little mischief never hurt anyone., 23. Dressed Up, Interview-Style, 24. 227/365: Exhausted.,

 

25. 225/365: Fuzzy sweaters make me happy., 26. 222/365: always a nice surprise..., 27. 219/365: Baby, it's cold outside., 28. 216/365: But I really wanted a whip, 29. 215/365: Of course I will still put on makeup., 30. 210/365: So we got these new chairs, 31. I can never get enough of him, 32. Day 208 Reject,

 

33. 203/365: Viva Las Vegas!, 34. 206/365: Thirty-One, 35. 202/365: 11:57pm, 36. 200/365: A picture is worth a thousand words, 37. 199/365: If this is not true love, I don't know what is., 38. 198/365: Don't Wait., 39. Pink Satin, 40. Inspired by Jessi,

 

41. Hiding in the bedroom., 42. View at 24,000 feet, 43. Home is not always the place you were born., 44. I don't want to doubt you/know everything about you, 45. Say I'm the only bee in your bonnet, 46. More SOTTS action, Roadtrip-style., 47. Alone., 48. If today were permanently erased from memory...,

 

49. Looking East., 50. What I wouldn't give to feel his touch right now., 51. In the basement, 52. I can run around in my underwear if I want, and you can't stop me., 53. SOTTS, Road Trip Style, 54. <3, 55. SSUC #4, 56. Bliss.,

 

57. Are we there yet?, 58. The timing came in handy., 59. But today I want to., 60. Anticipation, intensified., 61. How do I look in Blue + Orange?, 62. Post-Launch debris, or clouds?, 63. If you want me to follow, you know I'll fly., 64. Sugar and spice and everything nice, that's what SSUC girls (and boys!) are made of.,

 

65. What a wicked thing to do..., 66. If you saw my face it would give everything away., 67. International Pajama Week, 68. Look me in the heart and tell me you won't go., 69. Frisky Friday, 70. Sometimes, when I close my eyes and hold very still, I can feel you here with me., 71. International Footwear Week, 72. Eating chocolate cake in bed naked - 365 Days: #75, 05/03/07,

 

73. 365 Days: #66, 04/24/07, 74. Bra, 75. International Hat Week - SHOWER CAP STYLE, 76. 365 Days: #27, 03/16/07, 77. 365 Days: #12, 03/01/07

 

Created with fd's Flickr Toys.

YAZD CITY-IN PROGRESS

 

The capital of Yazd province, a relaxed city surrounded by desert.

the city of Yazd’s first mention in historic records predate it back to around 3000 years B.C. when it was related to by the name of Ysatis, and was then part of the domain of Medes, an ancient settler of Iran.

 

In the course of history due to its distance from important capitals and its harsh natural surroundings, Yazd remained immune to major troops' movements and destruction from wars, therefore it kept many of its traditions, city forms and

architecture until recent times.

 

During the invasion of Genghis Khan in the early 1200’s A.D. Yazd became a safe haven and home for many artists, intellectuals and scientists fleeing their war ravaged cities around Persia.

 

Yazd was visited by Marco Polo in 1272, who described it as a good and noble city and remarked its silk production. Isolated from any approach by a huge tract of monotonous desert, the vibrancy of Yard is invariably a surprise.

 

For a brief period, Yazd was the capital of Atabakan and Mozaffarid dynasties (14th Century A.D.). During Qajar Dynasty (18th Century A.D.) it was ruled by the Bakhtiari's Khans.

 

The city of Yazd is located in the eastern part of central Iran situated on the high, desert plateau that forms much of the country. Amidst the immense desert, Yazd retains its sterling of old in religion, traditions and architecture. Recognized by

UNESCO as holding one of the oldest architecture all over the world.

 

The word Yazd means, feast and worship, The city of Yazd has resisted the modern urbanization changes and maintained its traditional structure. The geographical features of this region have made people developed special architectural styles. For this reason, in the older part of the city most houses are

built of mud-bricks and have domed roofs. These materials served as insulation preventing heat from passing through.

 

The existence of special ventilation structures, called Badgirs(WIND TOWER) on the roofs is a distinctive feature of the architecture of this city (A Badgir is a high structure on the roof under which, in the interior of the building, there is a small pool). Therefore, Yazd has presented its stable identity at the foothills of the 4000 meter Shir Kooh.

 

Jame Mosque

The Jame Mosque (Friday Mosque) crowned by a pair of minarets, the highest in Persia, the portal's facade is decorated from top to bottom in dazzling tile work, predominantly blue in colour. Within there is a long arcaded court where, behind a

deep-set south-east Ivan, is a sanctuary chamber. This chamber, under a squat tiled dome, is exquisitely decorated with faience mosaic: its tall faience Mihrab, dated 1365, is one of the finest of its kind in existence.

 

The Mosque was largely rebuilt between 1324 and 1365, and is one of the outstanding 14th century buildings in Persia. The tile work has recently been skilfully restored and a modern library built to house the mosque's valuable collection of books and manuscripts.

 

Zoroastrians have always been populous in Yazd. Even now roughly ten percent of the town's population adhere to this ancient religion, and though their Atashkadeh (Fire Temple) was turned into a mosque when Arabs invaded Iran, a dignified new fire temple was inaugurated thirteen hundred years later.

 

Atashkadeh (Fire Temple)

Atashkadeh (Fire Temple) intitates meet there, but nobody apart form the Moubad (Grand Priest), a descendant of the Magi, reciting the Avesta, has access to the Moubad-e Moubadan (Saint of Saints) where for the past 3000 years a fire burns in a brazen vessel. The fire itself is a representation of what is good.

 

Being located beside the central mountains, far from the sea, adjacent to the kavir and in the shadow rainy region, Yazd has a climate which mostly resembles dry desertic climate. Little rain along with high water evaporation, relatively low

humidity, high su radiation and great temperature changes are among the factors making this province, one of the driest parts of Iran. The only moderating climatic factor is height and so, there is a pleasant climate dominant in Shirkuh heights.

 

Justina Mutale Foundation of Leadership Official Launch at the House of Lords Westminster London Q&A Moderated by Margaret Ali

Moderates Flee The Republican Party! They Are Showing Their True Colors With Their Anti Culture, Anti Black, Anti Mexican, Anti Bilingualism, Anti French, Anti World, Anti Heritage, Anti Spanish, Anti Civil Rights, Anti Anything Not White, English, & Blue Eyes. The Republican Party Is Putting On The Sheets And They Are Not Hiding It No Longer. They Are Proud White Men & Women Who Believe They Are Superior To All Other Colors & Heritage. You Don't Have To Vote Democrat. Just Don't Vote Republican. If You Pal Around With Racist Then You Are A Racist. If You're Voting Republican, Then You're Voting 'White Only' In That Ballot Box.

 

want proof that the gop and the kkk are one in the same...

 

KKK Disbands Claiming GOP Has Co-opted All Of Their Ideas

 

Pulaski, Tennessee - The Ku Klux Klan officially disbanded today claiming that the Republican Party has co-opted all of their ideas concerning race, immigration and religion and that there was no longer any need for their existence.

 

In a jubilant and sometimes rowdy ceremony, Grand Wizard Floyd T-Bone Perkins said, "We consider it a measure of our success that the Republicans have picked up our torch and carried it across the entire country. We were especially pleased with what the Republicans did in Florida in the elections of 2000. The way they kept the coloreds from voting was awe inspiring. And then they did the same thing in Ohio in 2004. Hell, their techniques were a whole lot better than ours. You might say, they learned from us and did us one better. But, that said, the most important thing is that the Republican Party has restored the country to what it is meant to be, a white Christian nation."

 

Most Klan members present supported the move to disband the KKK and said that they had felt welcome in the Republican Party for a long time. White House spokesperson Tony Snow was unavailable for comment."

 

assimilatedpress.blogspot.com/2006/07/kkk-disbands-claimi...

Moderated High-Level Policy Session 14: Knowledge societies,

capacity building and e-learning / Media

 

Speaking: Dr. Madeleine Scherb, President, Health and Environment Program

 

©ITU/R.Farrell

The following entities are all related to the icy planet of Alfriiden in the Epsilon Octant. Inhabitants of this planet such as these are known as Alfriidenizens.

 

• Ountyjend: An aquatic beast of moderate size that is the top predator within the underwater portion of Alfriiden's ecosystem. The Ountyjend is a short, one–eyed sea serpent with a fairly unique shape (especially in regards to its cranium) and, much more uniquely, very powerful and distinctly humanoid–like arms with fully articulated hands. Ountyjends use these arms and hands to punch their prey to death, and also to pick up dead prey (to eat it) and other things much like humanoids do. They are thusly considered by many analysts, scholars and animal enthusiasts to be among the "coolest" aquatic creatures in the Nava–Verse, as they not only go around punching things by nature, but do so underwater, a behavior which is unique to them in all of nature. Other abilities and traits of note exhibited by this creature include very fast swimming using the tail fin, and the presence of a long, gangly antenna that will severely disorient the Ountyjend for some time if severed, though it is more sturdy than it may appear and will grow back within a week's time. Ountyjends reproduce by laying large and singular spotted eggs and leaving them in well–hidden places. These eggs often contain multiple offspring, yet only one fully–developed young Ountyjend will ever emerge from a single egg, for multiple offspring within one egg will start fighting each other until only one remains alive after a certain stage in the gestation cycle. This often prepares Ountyjends for the aggressive lives that they will subsequently lead.

Like other inhabitants of Alfriiden's waters, Ountyjends are highly resistant to cold, as they need to be to survive in such waters. The creature's durability value is 800, and its maximum lifespan is thirty years. Along with Grobehoms, Ountyjends are some of the most sought–after creatures by Shepescuo hunters, as their meat is considered a delicacy among the nomadic race, and their bones may often serve as trophies and/or symbols of authority/accomplishment. It is very difficult and dangerous, however, for a Shepescuo to successfully catch one.

 

• Shepescuo: The native humanoid race of Alfriiden. The Shepescuos are a pudgy, average–sized race consisting mainly of nomadic groups and settlements of cultists serving Icksel'Mashe (see below). Their racial diet is notably composed almost entirely of meat, due to very few edible plants existing on Alfriiden. Despite being less than technologically savvy, they have above–average innate intellect and acute adapted survival instincts, and are by no means dumb despite their relatively primitive society. The average Shepescuo's body is between one meter and five feet in height, and the race's mean durability value is 650. Their skin is very cold–resistant, as it needs to be for them to thrive on Alfriiden, and is mostly smooth covered in grey fur on the upper part of the body, while the lower part of the body (from the waist down) is more rough, jagged and colorful, to the point that it is basically immune to all but the most extreme colds. Because of this, Shepescuos usually wear heavy clothing only over the upper halves of their bodies except when enduring particularly extreme climates, and such clothing generally consists of hooded jackets made mainly from the fur of animals. One other unique physical feature of the Shepescuo is the presence of a large thumb located beneath the other four fingers of its hand.

In terms of behavior and personality, Shepescuos are generally rather bitter and disgruntled, and at worst hostile to outsiders visiting their planet, which is understandable, albeit not excusable, given the difficult lives most of them lead in the inhospitable environment of Alfriiden and their high child mortality rates which are due to them taking some time from birth to develop sufficient cold resistance. In addition, their average natural lifespan is only fifty years; very short for a humanoid race. Because of this, many (but not all) Shepescuos have turned their proverbial backs to God, and turned their proverbial fronts to the resident Primal Deity of Alfriiden, Icksel'Mashe, who in exchange for the humanoids' allegiance offers them unnatural powers including greater resistance to their planet's environment and increased longevity. It has been estimated from the most recent census in Age 840 that roughly 30% of the current Shepescuo population serves Icksel'Mashe.

 

• Icksel'Mashe: A "male" ice–based Elemental–Class Primal Deity who has dwelled on Alfriiden since his spawning prior to Age 0 Relative, and has always been very powerful and popular among the mortals there, those being the Shepescuos, due to the very harsh conditions on Alfriiden and his ability to alleviate them for the humanoids. Icksel'Mashe's physical form stands roughly fifteen feet tall, and his durability value is 12,000, making him a fairly lesser deity in these regards, though his powers are great, especially on a very cold and icy planet such as Alfriiden which amplifies them. As is to be expected from an ice elemental, the matter that makes up most of his body resembles ice and snow, and his entire body is freezing to the touch, though it does not outwardly project its coldness to the surrounding area unless Icksel'Mashe wills it. In particular, Icksel'Mashe's "heart", the tiny mass of ice located at the center of mass of his physical being, is absolute zero in temperature, and would freeze the body of any living being who touched it. Also, his body is lopsided in that his left arm is considerably larger than his right, and tends to droop.

Since his initial appearance on Alfriiden, Icksel'Mashe has controlled a large portion of the Shepescuo population, as mentioned in the above entry on said humanoids. His cult is known as "Icksel'Mashe's Posse of Coolness", which should give one a hint as to the Primal Deity's personality, which is bombastic, immature and often stupid. He constantly speaks using juvenile and often strange slang as well as ice–related puns, and his voice itself resembles two high–pitched Shepescuo–like voices, one male and one female, speaking simultaneously over one another. Icksel'Mashe also frequently sings in strange rhythms with mostly nonsense lyrics, and has a rather distinctive, childish laugh. He often makes strange demands of his Shepescuo subjects, some of which clearly serve no purpose other than simply amusing his whim, and is also quite perverted, being physically attracted to Shepescuos of both genders and frequently making them perform sexual acts on each other in front of him; he himself does not and cannot participate in such orgies, however, being content with simply watching. Icksel'Mashe is in many ways less intelligent than most of his Shepescuo subjects, who continue to serve him mainly out of desperation, addiction and slight brainwashing. The ice deity is not ignorant, however, in that he does take note whenever his subjects are starting to become fed up with his antics and demands, in which event he panders to them with excesses of his "miracles" to ensure that they remain loyal. These "miracles" which Icksel'Mashe can bestow on his subjects include increased resistance to freezing cold temperatures to the point of near–total immunity, increases to one's lifespan by up to about twenty years, and increases to general physical strength, all of which are done through applied magical mutation, and he has also used his manual ice powers to create more advanced and efficient shelters (i.e. ice castles) for some of his longer–standing subjects. Overall, Icksel'Mashe is not as actively evil or dangerous as most Primal Deities, but as is the case with all Primal Deities, serving him is heavily compromising to one's soul and ability to enter Heaven.

 

• Grobehom: The top predator among the land–based Alfriidenizens. Grobehoms are large (up to twelve feet tall), severely hunchbacked, arguably beast–hominid mammalian creatures that live, hunt and travel in family units of three to five, as opposed to each individual living alone as is the case with several similar creatures on other planets such as the Sardoompa of Xekawiy and the Dredurcoz of Wrenchaii, Ergnoplis. Indeed, Grobehoms are on the whole far more social and capable of emotion than most other large beast–hominid predators in the Prime Galaxy. They mate for life, stay with their offspring for approximately twelve years, and will become quite distraught if separated from family members, to say nothing of when family members are killed. They are also capable of recognizing other individuals of their kind besides family members and forming rudimentary bonds or even "friendships". Note, however, that these emotional capacities of the Grobehom extend only to others of its own kind, and the creature is a vicious predator that hunts down and kills prey without mercy or restraint, and in fact does so more than other predatory creatures. Each adult Grobehom kills and eats an average of 3.2 organisms of significant size per day. Although Shepescuos are not part of their diet in that they do not actively hunt for them, they generally will attack and kill the humanoids if and when they happen to encounter them. These attacks, along with the fact that Grobehoms can naturally live much longer than Shepescuos and generally have easier lives overall, has led the Shepescuos to consider these beasts to be their greatest and most hated enemies, as well as the most desirable "game" to hunt on Alfriiden. The humanoids actively hunt the creatures, but take great care and caution in doing so, studying targeted individuals and families from afar, identifying their home caves and/or regular hunting grounds, and ambushing them in large groups. Though Grobehom meat is not very tasty, Shepescuos consider it a high delicacy due to how hard it is to obtain and the "glory" it represents to them, and the creatures' severed and stuffed heads and/or other body parts are sometimes kept as trophies, more commonly among Shepescuos who belong to Icksel'Mashe's Posse of Coolness than among those who don't.

The durability value range for Grobehoms is 2,000–3,000.

Merry Christmas 🎄🎁 *Insert generic Holiday caption replacing ‘cheer’ with ‘beer’* @breckbrew Christmas Ale to unwrap the gifts and bring some joy!

.

.

.

.

.

#christmas #present #beer #cheer #holiday #holidays #holidayseason #drinks #drank #ale #bottle #hawaii #christmasdecor #bow #ribbon #tattoo #brew #colorado #fun

 

317/365 (1/1/2023) extra alternate

46/52 (week of 1/1/2023)

Womens Clothes Boudoir Sexy Clothes dancer clothing mini skirts mini Halloween Costumes dresses mini dress dancing vampire clothes French maid party dresses corset formal wear gown gifts gift box costumes sexy clothes girly pink party club wear

 

Posted by Second Life Resident Torley Linden. Visit Tenney.

At Azuma Gorge on Iruma River in Hanno near Tokyo

Moderate scan of Fujichrome slide taken with Canon 'new' F1. To take this photo yourself camp on the world's highest lake-Peru's Lake Titicaca almost 4000 metres above sea level-and wait for a full moon and then photograph it with a 300ml lens on tripod focusing on the full moon (but less depth of field) using a loooong exposure - some two minutes in this case-as the camera's metering system is completely confounded. Need to be rugged up as maybe 20C below. But the eerie stillness of that night still benignly haunts me and is why I call myself "moonriverdiver". although Jerry Butler version of the song helped too.

NLS and Bad Wolf Superstore - All your time travelling requirements - console rooms, exteriors, accessories, sonic devices, Doctor Who, TARDIS, Tower Bridge, free cycle and boat hire

 

Taken at TARDIS Quay - NLS and Bad Wolf superstores, South Park (219, 142, 24)

If you are interested in commissioning a wool sculpture, please email me and I will gladly work with you on any project. I have options available for almost any budget.

 

If you are interested in a print of this image, please email me and I will list one in My Store! I will also create custom products such as greeting cards for you.

 

Details here & here

 

This little guy is part of a series of wool dragons I'm creating. Check out the others:

Lesser Water Dragon

 

Here's a species sheet on the Lesser Earth Dragon I wrote up. I don't know how zoologically (is that the right word?) accurate it could actually be, but it was fun to write anyhow!

    

Lesser Earth Dragon:

Size: 5-8" females are larger than males

Diet: Mainly insects, small rodents, and occasionally small lizards and birds. Like all dragons it will ingest certain rocks and minerals and has also been known to eat berries and grasses on rare occasions.

Habitat: Widespread in forests and meadow areas especially where there are rocky areas to provide necessary minerals

Clutch Size: Average of 2-5 eggs

Breeding: Pairs breed in early spring and lay eggs 3-5 weeks later. Eggs hatch between 65-75 days later and the pair will raise and hibernate with the dragonets until the following spring when they kick the yearlings out in preparation for the next clutch

Hibernation: From late fall to early spring. In more temperate climates they will brumate during the cooler months.

    

The lesser earth dragon is a small semi-reclusive dragon. While fairly common it is often hard to find due to its splendid camouflage. When directly threatened it will spread its wings to their full extent to show off the fake eyespots in an attempt to appear larger and scare predators away. It has also been observed to leap backwards towards a predator while displaying the fake eyes.

    

The lesser earth dragon spends most of its time hunting for prey alone or in groups. They are not territorial and often nest close to other pairs. Groups have been seen chasing larger predators away from nesting areas. Pairs mate long term and share parental duties. Preferred nesting areas vary, but are always enclosed. They are most often found in hollow logs & trees, abandoned animal burrows, and rock piles.

    

Capturing a wild lesser earth dragon usually results in a vicious and unhappy dragon and ultimately will probably cause its death, but they can make loyal companions if they are raised by hand from an egg. Stealing eggs from a community guarded nest is not the simplest task, but if done properly will cause no harm to the dragons. It is only recommended to take 1 or 2 eggs from a large clutch and leave smaller clutches alone. Separating a mating pair almost always spells death for male, female, and dragonets since the pair will look for one another and the responsibilities of raising dragonets is more than one adult can handle.

            

About My Sculptures

My wool sculptures are created by needle felting wool fiber into shape. I love to create highly detailed sculpture and I felt incredibly firmly to give my sculptures strength and durability. They have very little give, will not squash, lose their shape, or fall or pull apart with mild to moderate play or handling. I am often known to toss mine into my purse to take them on outings and my cats have gotten a hold of, bunny kicked, bitten, and shook some of my pieces and all have survived with little to no damage. Most wool sculptures are not meant to be given to children, but I do my best to make my sculptures able to stand up to to gently play from a child who knows how to take care of toys.

    

Because I spend that extra time to make my felting so firmly my pieces often cost more than others you may come across. Rest assured that if you choose to purchase one of my pieces you will not be disappointed with my work and they will last for a very long time.

    

About Needle Felting

Needle felting is the laborious process of taking carded wool fiber and sculpting it using a special barbed needle. Using this needle I stab the wool fleece many thousands of times. Each stab weaves and compresses the fibers together, creating the shape of the piece.

 

© Julia Grace Arts

Do NOT reproduce, use, or distribute without permission. Check out my usage guidelines here.

Please DO Feature on Flickr, Pin, Share, or Tweet my work!

  

Quick Links

Photostream | Profile | My Website | Store | Blog | Twitter | Facebook | deviantART | Pinterest | Goodreads

Axel Threlfall (Editor-at-Large, Reuters) moderates the panel session on "Connecting vehicles and infrastructure" at the International Transport Forum’s 2019 Summit on “Transport Connectivity for Regional Integration” in Leipzig, Germany, on 22 May 2019.

Moderated by Terry Kramer