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Interestingly enough, 2 1/2 years later, this mushroom planted itself adjacent to this Sons of the American Revolution Blankenbaker family grave marker at the cemetery located on Papa Johns Pizza's property.
This tragic train vs. auto accident occurred a few weeks ago and a young life was taken - he was only 19 years old. He apparently attempted to make a right hand turn crossing the tracks. From looking at the scene it appears the train pushed the car with such a force it went airborne and landed over a hundred feet into a deep ditch. My sincerest condolences to all involved. But there are *no* gates. The following photos depict the scene and are quite disturbing considering this loss of a promising young life could have and should have been prevented and was not.
There have been similar accidents at this same crossing in the past.
This is what is confusing to me:
East Blue Lick Road Add gates to existing flashing lights and bell system at CSX Railroad Crossing on East Blue Lick Road. (343 526X) Add to TIP as part of KIPDA #174 Various general rail/highway protection improvement program projects. Add FY2014 Construction $240,000 federal; RHPD funding
So WHERE ARE THE GATES? Better yet where is our $240,000 and the BIDS for a $50,000 job.
www.kipda.org/files/PDF/Transportation_Division/TIP/FY201...
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www.wlky.com/news/bullitt-county-officials-at-scene-of-de...
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UPDATE: I was informed today June 7, 2018, gates have been installed at this crossing now - unsure how long ago they were installed, but they're up and hopefully functioning correctly. Thank you.
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In speaking with the nice guard outside today, he says Amgen is a laid-back place to work and the noise levels are typical for a warehouse. It is a large shipping warehouse for cancer treatment drugs. They recently expanded.
12000 Plantside Dr, Louisville, KY 40299
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From Wikipedia - a little history:
The company has made at least five major corporate acquisitions.
Timeline
1980. William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Normam Davidson, Leroy Hood, Arnold Berk, John Carbon, Robert Schimke, Arno Motulsky, Marvin H. Caruthers, and Dave Gibson.[7]
1989. Amgen received approval for the first recombinant human erythropoetin product, Epogen, for the treatment of anemia associated with chronic kidney failure. Epogen (also marketed by Johnson and Johnson under the tradename Procrit) would later be approved for anemia due to cancer chemotherapy, anemia due to treatment with certain HIV drugs, and for the reduction of the need for transfusions associated with surgery.[8]
1991. In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy.[9] A 2002 meta-analysis found that Neupogen treatment reduced the risk of febrile neutropenia by 38%, reduced the risk of documented infection by 49%, and reduced the risk of infection-related mortality by 40%.[10]
1998. In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha).[8] A 2006 assessment by the National Institute of Clinical Excellence of the United Kingdom concluded that etanercept and related rheumatoid arthritis drugs later introduced by competitors "are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs, improving control of symptoms, improving physical function, and slowing radiographic changes in joints."[11] A more recent study demonstrated that compared to traditional disease-modifying anti-rheumatic drugs, treatment with etanercept improved survival, reduced cardiovascular events and reduced the incidence of hematological cancers.[12]
2010. On June 6, 2010 Amgen received FDA approval for Prolia, a protein drug for the treatment of post-menopausal osteoporosis.[13] In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%.[14]
2010 In November 2010 the FDA approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors.[15] The clinical trials primarily enrolled patients with breast or prostate cancer.
2012. Illegal marketing practices. The Los Angeles Times reported on December 18, 2012, that AMGEN pleaded guilty and agreed to pay $150 million in criminal penalty and $612 million to resolve 11 related whistleblower complaints. Federal prosecutors accused the company of pursuing profits while putting patients at risk.[16] Larry Husten, a contributor at Forbes.com elaborates on AMGEN's illegal marketing practices in this case, namely that the "government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices".[17] One of the drugs mentioned in the lawsuit had sales of $492 million in the third quarter of 2012, down 17% from the same quarter the previous year due to "reimbursement problems and label changes".[18]
2012. Amgen paid $762 million after pleading guilty to criminal charges of improper promotion and sale of misbranded drugs.[19]
2013. Lawmakers inserted text into the fiscal cliff bill that will allow the drugmaker to sell a class of drugs that includes Sensipar without government controls for an additional two years. The New York Times estimated that the paragraph in the fiscal cliff bill will cost taxpayers an estimated $500 million[20] but other assessments concluded that the change would protect seniors in rural areas and reduce overall Medicare spending.[21][22]
2015. In September the company announced it would acquire Dezima Pharma for more than $1.55 billion.[23] The same day the company announced a collaboration with Xencor on 6 early stage immuno-oncology and inflammation programmes. As part of the deal Amgen will pay $45 million upfront, with the deal being worth up to another $1.7 billion.[24][25]
2016. In September, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma.[26]
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From the Wall Street Journal 5/29/21: A pathbreaking pill for lung cancer from Amgen Inc. was approved by the U.S. Food and Drug Administration, adding a new potential blockbuster to the biotech giant’s aging stable of drugs.
The drug, called Lumakras, was approved Friday to treat a portion of lung cancer patients with a particular genetic mutation who have already tried other therapies.
The mutation, known as KRAS, is among the most common found in cancers, but researchers struggled for so many years to find a medicine that can treat it that the mutation came to be considered “undruggable.”
Amgen Wins Approval for Pathbreaking Lung Cancer Drug (By Joseph Walker
Updated May 28, 2021 3:42 pm ET): www.wsj.com/articles/amgen-wins-approval-for-pathbreaking...
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It is ironic that stem-cell treatment is used in other Nations successfully in combating cancer, yet not in the USA.
Left to right - Peter, Duke of Coimbra (son of King John I of Portugal)
Queen Philippa of Lancaster
Fernão Mendes Pinto (explorer and writer)
Frei Gonçalo de Carvalho, O.P. (Dominican Missionary)
Frei Henrique de Coimbra, O.F.M. (Franciscan Missionary)
Luís de Camões (renaissance poet who celebrated the navigations in the epic Lusiads)
Nuno Gonçalves (painter)
Gomes Eanes de Zurara (chronicler)
Pêro da Covilhã (traveller)
Jácome de Maiorca (Jehudà Cresques, cartographer)
Pedro Escobar (pilot)
Pedro Nunes (mathematician)
Pêro de Alenquer (pilot)
Gil Eanes (navigator)
João Gonçalves Zarco (navigator)
Ferdinand the Holy Prince (son of King John I of Portugal)
Pancake met this gorgeous Australian Shepherd while donating some items to the Kentucky Humane Society today, and what a beautiful blue-eyed pup this was!
Purchased these for my dog. They were rancid. They did have the USDA seal of approval on the packaging. "Shrink wrapped". They were farmed in Kentucky. Does not appear this animal got much exercise, minerals or sunlight and was quite stressed: www.jbc.org/content/65/3/643.full.pdf
THE INFLUENCE OF SUNLIGHT ON BONE DEVELOPMENT
IN SWINE.
BY L. A. MAYNARD, S. A. GOLDBERG, AND R. C. MILLER.
(From the Department of Animal Husbandry and the Department of Comparatiue
Pathology and Bacteriology, Cornell University, Ithaca.)
(Received for publication, July 6, 1925.)
A report has recently been made by the writers (1) on the dietary
relationships and the pathology of a condition in swine popularly
referred to as stiffness, paralysis, rickets, and by other terms.
In this previous study the principal and constantly occurring
lesions in the stiff pigs were found in the bones and these lesions
were accompanied by a deficiency of calcium and phosphorus as
shown by chemical analysis of the femurs. The stiffness was
found to occur with a ration low either in calcium or in the factor
aiding its assimilation. The correction of the ration with respect
to these deficiencies was found effective for preventing or curing
the trouble.
In this previous study the animals were housed in pens on the
north side of the colony house and were never exposed to any
direct sunlight. In view of the findings that the stiffness was
apparently a result of faulty mineral nutrition the question naturally
arose as to how the results would be modified where the pigs
were exposed to sunlight. The results reported in the present
paper deal with a study of this question.
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Note if one does file a complaint with the USDA on a rancid or compromised product this will be the response:
"After receiving your complaint, FSIS conducted an analysis and review of CCMS (Consumer Complaint Monitoring System) data, as well as the inspection of records from the establishment that produced the product in questions. We did not find any trends or conditions at the establishment that warrant further action at this time. However, we have notified the manufacturer and FSIS establishment personnel of your complaint, and they may conduct additional review."
Got this pumpkin from Kroger's to cut up for a casserole. Needless to say we were not able to use much of it. With their defunct return policy I'm sorry I cut it up. Would have made great target practice. : )
Label says from: Stumler Farms "Product of USA" Fredericksburg, IN
#4735
Not sure where this ditch ends but it doesn't look good. Standing water remains days after rainfalls. Undermining can be seen to the left. It does, however, provide safe harbor for bats frequently seen loitering above at night and produces ample supplies of gnats for local spiders. Offers unlimited free storage and effortless return of Kroger's shopping carts.