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Peeling Tree Bark Disease - Hardwood trees that have peeling bark may be suffering from a fungal disease called Hypoxylon canker. Peeling bark caused by this disease is accompanied by yellowing and wilting leaves and dying branches. In addition, the wood under the peeling bark is covered with a mat of fungus. There is no cure for this disease and the tree should be removed and the wood destroyed to prevent the spread of the fungus. Cut down the tree as soon as possible to prevent damage and injury from falling branches.
Read more at Gardening Know How: Peeling Bark On Trees: What To Do For Trees That Have Peeling Bark www.gardeningknowhow.com/ornamental/trees/tgen/peeling-ba...
Left to right - Peter, Duke of Coimbra (son of King John I of Portugal)
Queen Philippa of Lancaster
Fernão Mendes Pinto (explorer and writer)
Frei Gonçalo de Carvalho, O.P. (Dominican Missionary)
Frei Henrique de Coimbra, O.F.M. (Franciscan Missionary)
Luís de Camões (renaissance poet who celebrated the navigations in the epic Lusiads)
Nuno Gonçalves (painter)
Gomes Eanes de Zurara (chronicler)
Pêro da Covilhã (traveller)
Jácome de Maiorca (Jehudà Cresques, cartographer)
Pedro Escobar (pilot)
Pedro Nunes (mathematician)
Pêro de Alenquer (pilot)
Gil Eanes (navigator)
João Gonçalves Zarco (navigator)
Ferdinand the Holy Prince (son of King John I of Portugal)
盼我瘋魔，
還盼我孑孓不獨活。
想我冷艷，
還想我輕佻又隨便。
攝影 戴群芳【Fong】女子攝影美學
主角👸 Fairy 雨䕕
場地🌼 R-room 攝影棚 / 場地租借 · 攝錄影服務
造型💄 Ginger makeup造型團隊
禮服💃 Lin Hui Chi Haute Couture 林卉祺高級訂製服
美鞋👠 ReSarah 時尚手作婚紗鞋/伴娘鞋/晚宴鞋/蜜月鞋
#ThisAttackComesFromTaiwan
#letsguide #Taiwan 🇹🇼
#Nikon #instagood
#DslrPhotographer
#戴群芳女攝影師
#LinHuiChiHauteCouture林卉祺高級訂製服
#GingerCMakeupHairArtist
#ReSarah時尚手作婚紗鞋
#Rroom攝影棚 #板橋
Spotted inside a Louisville Metro Government / Jefferson County office building. Yes, there are people working in there. Not sure if our Mayor does. Note the open, exposed wires w. system anchored on a small piece of plywood. Spare parts on top.
Mayor Fischer's Office: (502) 574-2003
Louisville City Hall: (502) 574-1100
"In 2006, the council passed two controversial ordinances: a smoking ban in October and the so-called "Dangerous dog" ordinance in December. In 2007, the council considered a ban on trans fats and non-biodegradable plastic bags.[2]?
Current Council President: 2016–present: David Yates (D)
Current Council Members:
The city of Louisville, Kentucky, will hold general elections for mayor and city council on November 6, 2018. A primary election may be held on May 22, 2018. The deadline for candidates to file to run in this election is January 30, 2018. Thirteen of the 26 city council seats are up for election in 2018. These include Districts 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23 and 25. The current members of the Metro Council are (by district number):
Jessica Green (D)
Barbara Shanklin (D)
Mary C. Woolridge (D)
Barbara Sexton Smith (D)
Cheri Bryant Hamilton (D)
David James (D)
Angela Leet (R)
Brandon Coan (D)
Bill Hollander (D)
Pat Mulvihill (D)
Kevin Kramer (R)
Rick Blackwell (D)
Vicki Aubrey Welch (D)
Cindi Fowler (D)
Marianne Butler (D)
Scott Reed (R)
Glen Stuckel (R)
Marilyn Parker (R)
Julie Denton (R)
Stuart Benson (R)
Vitalis Lanshima (D)
Robin Engel (R)
James Peden (R)
Madonna Flood (D)
David Yates (D)
Brent Ackerson (D)
Ordinances[edit]
This section needs expansion. You can help by adding to it. (January 2007)
Pinnacle Gardens
Board of Directors Meeting
July 9, 2012
The July regular monthly meeting was called to order at 6:30 p.m. by President Sandy Athanasakes.
Other board members present were Dan Palacios, Ben Lampton, Bill Gaar, Nancy Chaplin, Tony Vick, Joe Jordan,
Phil Hanna, and Teresa Good. Dan Rapp attended and represented Ky. Realty
6. It was brought to the attention of the board that there is a buckled area of sidewalk along Factory Lane that could
cause a fall.
------------->
To: boardmembers boardmembers@pinnaclegardens.org
Ccathanasakess athanasakess@bellsouth.net
Sent: Tue, Jun 24, 2014 7:58 am
Good Morning -
I was just walking my dog out front and noticed the sidewalk has become uneven and has settled in a few spots - I'm sure the board is aware of this but wanted to ensure you were as this could be a liability if anyone were to get injured, trip or fall. It is quite noticeable and many joggers do run by there as there were this morning. This appears to be an unstable area as the sidewalk has also buckled on the other side of the street as well so you may want to check that. I also see the area adjacent to the blacktop (road) has also settled a few inches so again it may be prudent for you to get some compaction tests run as this was also close to where we'd had the water main undermining a few years ago.
As always, ensure your insurance covers ground settlement in this area. Mine changed this without my knowledge, FYI.
The area in question is directly in front of the stone entrance in front of David Ballard's home where I see there was a water markout not too long ago. You will see where the concrete sidewalk blocks have shifted.
*************************************************
Board Of Directors
Sandy Athanasakes - President
Phillip Hanna - Vice President
Nancy Chaplin - Secretary
Jean Kellett - Treasurer
Ben Lampton - Member at Large
Debbie Jordan - Member at Large
Dan Palacios - Member at Large
Cesar Cestero - Member at Large
Gary Stinson - Member at Large
Pinnacle Gardens Newsletter States as of June 2012:
Sandy Athanasakes- sathanasakes@pinnaclegardens.org – President
Ben Lampton- blampton@pinnaclegardens.org – Vice President
William Gaar- wgaar@pinnaclegardens.org – Treasurer
Nancy Chaplin – nchaplin@pinnaclegardens.org – Secretary
Phillip Hanna- phanna@pinnaclegardens.org – Member at Large
Joe Jordan – jjordan@pinnaclegardens.org – Member at Large
Dan Palacios – dpalacios@pinnaclegardens.org – Member at Large
Tony W. Vick – tvick@pinnaclegardens.org - Member at Large
Teresa Good – tgood@pinnaclegardens.org – Member at Large
Management Company
Kentucky Realty Corporation
Site Manager: Dan Rapp
Phone: (502) 473-0003
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These front-line firefighters battling this Dodge Durango SUV fire here in Louisville, Kentucky, USA were outstanding. They put their lives on the line for us all each and every day.
SAFETY:
Model-by-model road accident statistics from the UK Department for Transport show that the Land Rover Defender is one of the safest cars on British roads as measured by chance of death in two-car injury accidents.[46] The figures, which were based on data collected by police forces following accidents between 2000 and 2004 in Great Britain, showed that Defender drivers had a 1% chance of being killed or seriously injured and a 33% chance of sustaining any kind of injury. Other four-wheel-drive vehicles scored equally highly, and collectively these vehicles were much safer for their passengers than those in other classes such as passenger cars and MPVs. These figures reflect the fact that drivers of large mass vehicles are likely to be safer, often at the expense of other drivers if they collide with smaller cars.
Actually, the gentleman on the right was wandering around this huge parking lot, stumbling, drooling, and eventually sat back onto some snow and laid down. What was so great about this scenario is the Burger King associates noticed this and sprung into action as they went outside and stood over him (he eventually was able to sit up, then stand up again) until the police arrived. One gentleman who stopped in a passing truck said he'd notified the police as he had a Son who was disabled and not able to walk and he was very concerned. Humanity is alive and well at Burger King.
The officers handled this very, very well. No one was beaten up. Eventually three officers were on the scene and all of them were very professional. I tip my hat to them on this one.
As I understood from what i could hear, he'd wandered from his Grandmother's house quite a distance away. There appeared to be some medication conflicts.
Burger King, unlike McDonald's, does not have a problem with customers or visitors using their phone to make 911 calls, if need be, which is always good to know.
"Tropical Depression" Harvey slowly taking over the Southeast. According to NOAA this "depression" was passing through Mississippi while kids played basketball here in Louisville, Kentucky, USA. Looks like this harmless "depression" might need some Prozac. www.nhc.noaa.gov/graphics_at4.shtml?cone
We visited Mohammed Ali's grave site in Louisville, KY, USA and it is indeed a beautiful site. It is said he wanted a modest burial place. The caretaker there today noted Ali had come himself to choose this particular site, and well chosen it is. In comparison with other memorials in this cemetery, it is indeed humble, beautifully designed, maintained and watched over. There are benches on each side of the steps if one wishes to sit and reflect and there is a small urn where passersby drop change after walking up a small grouping of solidly placed stone steps. It is beautifully landscaped with petunias, dahlias, ivy, begonias and other bright, colorful flowers. This is definitely a peaceful, inspiring place and well worth the visit. Pictured: Nadia and David.
About our friend, Nadia:
Nadia Kennedy (adopted name), born 10/16/98, was possibly born in Kiev, Ukraine. She relays that her birth parents in Russia were reported to the government as being addicts and alcoholics and their neighbors called the police on them. Both babies (or toddlers) Nadia and her sister were removed from the home and placed in separate "baby houses", aka a place where they sorted out babies to determine which were healthy enough to stay in Russia and which would be offered out to other nations for care and adoption.
Nadia stated her sister is one year younger than she is. Her sister's birthday is 8/4/99. She wants to locate her sister. Please do share this link/photo with anyone you know who might know the whereabouts of her long lost Ukraine sister.
Nadia says she was born with fetal alcohol syndrome. You can read about fetal alcohol syndrome here: www.cdc.gov/ncbddd/fasd/facts.html
Her maternal adopted Grandparents currently reside Woodbury, NJ. Her adoptive parents currently reside in Florida.
Interestingly enough, 2 1/2 years later, this mushroom planted itself adjacent to this Sons of the American Revolution Blankenbaker family grave marker at the cemetery located on Papa Johns Pizza's property.
Once it was one of the largest brick homes in Charles County, Maryland. Once it was the site of an amusement park. Once it was burned by arson. Once a truck drove through the middle. And now...
In speaking with the nice guard outside today, he says Amgen is a laid-back place to work and the noise levels are typical for a warehouse. It is a large shipping warehouse for cancer treatment drugs. They recently expanded.
12000 Plantside Dr, Louisville, KY 40299
********
From Wikipedia - a little history:
The company has made at least five major corporate acquisitions.
Timeline
1980. William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Normam Davidson, Leroy Hood, Arnold Berk, John Carbon, Robert Schimke, Arno Motulsky, Marvin H. Caruthers, and Dave Gibson.[7]
1989. Amgen received approval for the first recombinant human erythropoetin product, Epogen, for the treatment of anemia associated with chronic kidney failure. Epogen (also marketed by Johnson and Johnson under the tradename Procrit) would later be approved for anemia due to cancer chemotherapy, anemia due to treatment with certain HIV drugs, and for the reduction of the need for transfusions associated with surgery.[8]
1991. In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy.[9] A 2002 meta-analysis found that Neupogen treatment reduced the risk of febrile neutropenia by 38%, reduced the risk of documented infection by 49%, and reduced the risk of infection-related mortality by 40%.[10]
1998. In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha).[8] A 2006 assessment by the National Institute of Clinical Excellence of the United Kingdom concluded that etanercept and related rheumatoid arthritis drugs later introduced by competitors "are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs, improving control of symptoms, improving physical function, and slowing radiographic changes in joints."[11] A more recent study demonstrated that compared to traditional disease-modifying anti-rheumatic drugs, treatment with etanercept improved survival, reduced cardiovascular events and reduced the incidence of hematological cancers.[12]
2010. On June 6, 2010 Amgen received FDA approval for Prolia, a protein drug for the treatment of post-menopausal osteoporosis.[13] In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%.[14]
2010 In November 2010 the FDA approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors.[15] The clinical trials primarily enrolled patients with breast or prostate cancer.
2012. Illegal marketing practices. The Los Angeles Times reported on December 18, 2012, that AMGEN pleaded guilty and agreed to pay $150 million in criminal penalty and $612 million to resolve 11 related whistleblower complaints. Federal prosecutors accused the company of pursuing profits while putting patients at risk.[16] Larry Husten, a contributor at Forbes.com elaborates on AMGEN's illegal marketing practices in this case, namely that the "government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices".[17] One of the drugs mentioned in the lawsuit had sales of $492 million in the third quarter of 2012, down 17% from the same quarter the previous year due to "reimbursement problems and label changes".[18]
2012. Amgen paid $762 million after pleading guilty to criminal charges of improper promotion and sale of misbranded drugs.[19]
2013. Lawmakers inserted text into the fiscal cliff bill that will allow the drugmaker to sell a class of drugs that includes Sensipar without government controls for an additional two years. The New York Times estimated that the paragraph in the fiscal cliff bill will cost taxpayers an estimated $500 million[20] but other assessments concluded that the change would protect seniors in rural areas and reduce overall Medicare spending.[21][22]
2015. In September the company announced it would acquire Dezima Pharma for more than $1.55 billion.[23] The same day the company announced a collaboration with Xencor on 6 early stage immuno-oncology and inflammation programmes. As part of the deal Amgen will pay $45 million upfront, with the deal being worth up to another $1.7 billion.[24][25]
2016. In September, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma.[26]
*******************
From the Wall Street Journal 5/29/21: A pathbreaking pill for lung cancer from Amgen Inc. was approved by the U.S. Food and Drug Administration, adding a new potential blockbuster to the biotech giant’s aging stable of drugs.
The drug, called Lumakras, was approved Friday to treat a portion of lung cancer patients with a particular genetic mutation who have already tried other therapies.
The mutation, known as KRAS, is among the most common found in cancers, but researchers struggled for so many years to find a medicine that can treat it that the mutation came to be considered “undruggable.”
Amgen Wins Approval for Pathbreaking Lung Cancer Drug (By Joseph Walker
Updated May 28, 2021 3:42 pm ET): www.wsj.com/articles/amgen-wins-approval-for-pathbreaking...
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It is ironic that stem-cell treatment is used in other Nations successfully in combating cancer, yet not in the USA.