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The original mid-13th-century Magdeburger Reiter (Magdeburg Rider, also Horseman of Magdeburg) is the main attraction of the Kunsthistorisches Museum. Further exhibits in this small local history and art museum include:
Banknotes from the hyperinflation period of the early 1920s, including a Billion Mark note (i.e. a million million marks) and a thousand mark note changed to a billion mark one through a simple red stamp.
Note presence of Maxwell House pitchwoman (and former Wicked Witch of the West) Margaret Hamilton.
Source: Woman's Day, November 20, 1978
This is just me, not the way I am choosing to show myself... like fake bloggers out there who write fiction. This is just who I am, I'm not sucking up to anyone.
.Elgar £20 note no longer legal tender
Have a look in your wallet: any £20 notes with the image of Edward Elgar on them will not be legal tender after June 30 this year.
This means that shops no longer have to accept the notes, and it is up to banks whether they agree to swap notes after this date.
From July 1 only notes with the image of Adam Smith, the Scottish economist, will be legal tender. These notes came into circulation in March 2007.
About 10 per cent of all £20 notes in circulation equating to 150 million notes, worth £3 billion are the old versions featuring the English composer. They were introduced in June 1999 along with a view of the west face of Worcester Cathedral, replacing the previous series of notes featuring Michael Faraday, the physicist, and before that William Shakespeare.
The Adam Smith design was introduced to cut down on forgeries. The new £20 design included more of the printed words raised and a greater number of flecks that show bright red and green under an ultraviolet light.
Old notes will eventually be sent to one of the official Government incinerators, where they will burned alongside damaged notes. A small amount of thermoelectric power is generated by these sites, which also burn illegal tobacco seized by HM Revenue & Customs at British ports.
After June 30 if a bank or building society refuses to swap a note, consumers have the right to swap the notes at the Bank of England itself. The Bank promises that it will honour the face value of any note issued, even notes from before the Second World War.
More finance stories from telegraph.co.uk
INFO FROM YAHOO HOMEPAGE
When making notes for genealogy I enjoy my vast collection of color ink pens. When I change sources or persons being researched I reach in and grab another color to make the notes.
Here is a picture I shot of my desk. Quite a mess I know. I added notes to describe some of the stuff you see on and around my desk.
Free texture. If you use this texture please credit my name under your picture, and put a copy of your work in a comment box under my texture.
i know it's slightly silly and cheesy, but we like to leave little notes for the other to stumble upon.
those little reminders are nice.
To rescue six American diplomats who evaded capture during the seizure of the United States embassy in Tehran, Iran, on 4 November 1979, CIA technical specialists created a fake movie-production company in Hollywood and delivered disguises and documents that made possible the diplomats’ escape from Iran in 1980. The team set up “Studio Six Productions” and titled its new production “Argo.” This document includes an Introduction, Story Treatment & Locations, and Visuals.
For more information on CIA history and this artifact please visit www.cia.gov
one of chris's favorite bars in nashville has coasters all over the walls with notes that people have written. this message was on one of them--front and center, right behind the bar.
i couldn't get a decent picture of it so i wrote it down on the receipt and tucked it away.
(14/351)
A wad of 50 euro notes
Like much of our work, we have put all these images in the public domain. Feel free to use them but please credit out site as the source if you do: TaxRebate.org.uk
Giving thanks to co-host Reid Hoffman with Ned from Harvard. More photos in comments below.
Such a fun weekend at an eclectic brain spa. I’ll share some of the highlights in my crude screen shots. Overall, it felt like we are in the midst of an interdisciplinary Renaissance, from novel measurement and imaging techniques to machine learning and bold new experiments in animal and humans.
We learned how super-absorbent diaper gel polymers can make a brain expand for easier imaging, and how it can be optically read and modified. At least five speakers referenced an explosion of interest in the rapid-acting drug ketamine (for depression and OCD) and a surprising finding that it operates through the opioid receptors.
We learned how vasopressin might treat autism and how girls of depressed mothers have radically different brain development and telomere length.
"While the male and female brain differ in development, the male and femaleness of the brain is regional." — Manpreet Singh
Notes from Day 1: SATURDAY, SEPTEMBER 8, 2018
New Conceptual Frameworks in Mental Health - Amit Etkin
I had lunch with him a well. He gets much more data from the EEG than the fMRI. We are generally poor at describing our mental state. Our friends generally do a better job on identifying if we are depressed.
10:00 am — Tools for Analyzing and Repairing the Brain - Ed Boyden
MIT’s Ed Boyden has the largest brain lab in the world, with 150 people.
Expansion microscopy is the opposite of normal microscopy. Instead of zooming in on the brain, you make the brain bigger with a polymer expansion similar to the gel found in super-absorbent diapers. youtu.be/jLvynWieWk8
Color coded with a virus payload for seeing different cells, a “brainbow”
www.ted.com/talks/ed_boyden_baby_diapers_inspired_this_ne...
Optogenetics, with light-activated ion channels: youtu.be/evisCB6mwt0
Can trigger brain activity at a targeted deep area with a pair of acoustic waves at close frequencies, like 2.00 and 2.01 Hz.
Digital Phenotyping - Tom Insel
He can deduce your mental state from social networks based on how you type and click (patterns in timing) not the content of what you type (less privacy concerns). Signals from the phone predict how the mood will be for the day. He can even see the effects of ketamine, a rapid-acting anti-depressant.
We can move from subjective, episodic, burdensome, clinic-based measurements to objective, continuous, passive in-situ measurements. 7cups is using it for alcoholic treatment.
11:00 am — The Supercharged Brain, Mental Health and Aging - Ruth O’Hara
The normal aging brain shrinks by 15% (Alzheimer’s another 10%). Depression shrinks the hippocampus, and that impairs memory.
Physical exercise and targeted cognitive training can improve your brain.
Very excited to grow neurons in a dish from skin stem cells. Easier to do with young people than the aged.
Envisioning the Brain Mind Clinical Lab of the Future - Leanne Williams
Imaging brain activity in cognitive dysfunction. Many different mental states we call depression, and they respond to treatments differently.
For example, sub-type 1 is characterized by Default Mode Network. If it becomes too connected, too much internal reflection, ruminations, worry, waking up early in morning, and unable to stop thoughts about terrible things might happen.
New Stanford Center for Precision Mental Health & Wellness.
Novel Platforms for Novel Treatments in Neuroscience - Rob Malenka
25% of the world will develop a serious brain malfunction in their lifetime.
If your brain is not functioning, you are not yourself. With addiction and OCD, you have no control over your behavior.
Anhedonia is a common symptom in depression, Parkinson’s and schizophrenia.
With all of the academic hysteria about ketamine, we still don’t know how it works, and it was discovered accidentally.
“An example”: we can make a mouse happy or unhappy.
Fireside Chat with Reid Hoffman - Reid Hoffman and Michael McCullough
In blitzscaling, you prioritize speed over efficiency in an uncertain world.
He also rekindled his AI interest 5-6 years ago.
2:00 pm — Revolutionizing Medical Imaging and Brain-Computer Communication with Consumer Electronics - Mary Lou Jepsen
If you spend 10-100 hours in an fMRI, we can read your thoughts. 2/3 of humanity lacks access to medical imaging. She wants to reduce the cost 200x and fit it into a ski cap.
Tumor has 5x the blood of normal tissue. And Blood is relatively opaque (versus flesh). Bones are white, and near IR passes through. We can image to 2 microns, the diameter of the smallest neuron. Use laser and sound wave that shifts the wavelength ever so slightly.
TED Talk just came out: www.ted.com/talks/mary_lou_jepsen_how_we_can_use_light_to...
3:10 pm — Shining a Light on the Treatment of Alzheimer’s Disease - Li-Huei Tsai
40 Hz flickering LED light induces gamma oscillations in the brain. After 1 hr of exposure, she saw a 50% reduction in amyloid plaques in a Alzheimer’s rat model.
The microglia (the brain’s immune cells) undergo dramatic transformation in their morphology and become much more efficient at picking up toxins like beta-amyloid.
To Sleep or Not to Sleep: How the Brain Decides to Wake Us Up - Luis de Lecea
Sleep decreases as we age and with Alzheimers (it’s the main reason AD patients get institutionalized).
How does the brain control sleep? The hypothalamus is only 3% of the volume of the brain but controls sleep, appetite and circadian rhythms.
Parabiosis – would the blood of the young mouse rejuvenate the old? The opposite occurred. Molecules in the old brain were toxic in the younger brain.
Quieting the Obsessive Mind: Ketamine and Other Rapid-Acting Therapeutics - Carolyn Rodriguez
In OCD, a thought continuously invades or intrudes in our mind. 2% lifetime prevalence. Half of cases start by age 19.
Only FDA-approved medication: SSRI’s like Prozac take 2-3 months, and fail half the time.
Ketamine is a glutamate-receptor-blocker which increases GABA in the pre-frontal cortex. But if you take naltrexone, which blocks opioid receptors, then ketamine loses its effect. This was a surprising result; there is some connection to the opioids.
Ketamine rapidly and dramatically lowers OCD, with effects lasting days post-treatment.
ADD: Karen Parker and Antonio Hardy on Autism
Why so few diagnostics and therapies in autism? The biology is poorly understood.
With early detection, you can gain 15 IQ points and lower the cost of care by 7%.
She studies monkeys on the anti-social extreme. Behaviors are similar to autism. Vasopressin helps. Perhaps vasopressin signaling is impaired in autism. When given to human childen, social behavior improves.
Accelerating Discovery to Promote Healthy Brain Outcomes Starting from Birth - Ian Gotlib
Adolescence is a period of suicide risk, and it’s getting worse. The CDC recently came to Palo Alto to look at what’s going on in this suicide cluster.
The biggest risk factor are 1) family history 2) being female
There are 200 million depressed mothers with daughters who have not become depressed yet. She studied those daughters. They have a big change from other similar aged girls. Smaller hippocampus. Shorter telomeres already by age 12. When they check in 10 years later, 60% of those girls became depressed.
By age 9-14, it might be too late already. So, they did infant studies and of the pregnant mothers (measuring continuous cortical level from hair samples during pregnancy). And they gathered a lot of passive data. The infant’s brain volume correlates with number of words heard in utero. And they were disturbed to see the strong correlation with income level.
Prenatal stress lowers hippocampal volume and amygdala connectivity.
Manpreet Singh
Brain is the most genetically determined organ in the body.
While the male and female brain differ in development, the male and femaleness of the brain is regional.