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Hippocampus and neurons of mouse with the neurodegenerative disease Niemann-Pick type C1. Credit: I. Williams, NICHD

Nicknamed "Freddy"

Un rollo "suavito" estilo "cabecero de cama".

camera toss in the car on the way home. I'm not the driver in case you are wondering

More Edinger-Westphal neurons in culture. Stained for Tubulin (green) and Synapsin (red). Of course, colocalization makes yellow. Imaged with a Zeiss Axioskop 2 FS Plus equipped with a Zeiss Axiocam HRm. 100x total magnification.

We usually name “our world” to the one that directly perceive with our senses. But as Paul Éluard phrased…. there is another world. Physical, psychic, and perhaps unknown ones are waiting for discovery. All the living beings have inside a cellular world to which we can only access by means of the microscope. It is a different but wonderful world.

Purkinje neuron. Human cerebellum. H.E.

Picture captured with a Nikon Eclipse 50i photomicroscope at 400X.

Solemos llamar "nuestro mundo" al que directamente percibimos con nuestros sentidos. Pero como dijo Paul Éluard...hay otros. Mundos físicos, psiquicos y otros tal vez desconocidos que esperan para ser descubiertos. Todos los seres vivos tenemos dentro un mundo celular al que solo podemos acceder mediante el microscopio. Es un mundo diferente y maravilloso.

Neurona de Purkinje. Cerebelo humano. H.E.

Imagen obtenida con un fotomicroscopio Nikon Eclipse 50i a 400X.

mirror neurons make u nice

starburst filtered self w black frame i-type 600 film shot on polaroid now+

Neuróptero( (Neuroptera, del griego neûron, "nervio" y ptéron "ala"; "alas con nervios) de 25 mm de longitud y 52 de envergadura alar, por su forma y conducta recuerda a una mariposa; sin embargo, sus alas, que no llevan escamas, son transparentes, amarillas en el primer tercio externo y pardooscuras en la cara interior. Tiene el cuerpo lleno de pelos negros.

Esta en peligro de extinción en algunos países y es muy raro de ver.

Yo pude ver 5 ejemplares y costó bastante hacerles algo decoroso, por lo que me siento privilegiado.

Gracias por los comentarios.

 

Uncharted territory: Ivan Soltesz, UC Irvine Chancellor's Professor and chair of anatomy & neurobiology, has helped shed light on the inner workings of the human brain… "The brain is the last great frontier," says Soltesz, UC Irvine Chancellor's Professor and chair of anatomy & neurobiology. "It's the most complex organism in the universe — endlessly challenging and interesting to study." In his 2005 book, Diversity in the Neuronal Machine, he describes the brain's neural landscape as a vast fecund forest, with neurons linking to "distal branches that form a wide canopy, just like the giant trees in the rain forests of Costa Rica." [from www.uci.edu/features/2012/01/feature_soltesz_120130.php ]

and now for something completely different... I've been watching classic episodes of Dr. Who lately so this is somewhat inspired by hours of watching that show.

 

Canon 5D Mk III with Canon EF 24mm F1.4L Mk II lens. 1/80th sec at F4, ISO 1600.

  

"Neuron" by Roxy Paine

Awesome sculpture at Meijer Gardens

www.meijergardens.org/explore/neuron/

Rokinon 8mm f2.8

Fri. t he 15th staying indoors. So just a few clicks today.

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Odd patterns on the ice of Shuswap Lake

Created with Frex

I have been talking with a fascinating scientist who’s working on genetically-modified neurons to innervate the brain from a silicon substrate. The goal — connect prosthetics to the cranial nerves and eventually, replace all sensory input to the brain with a computer interface. Well… how complicated would this be? While the human brain has 86 billion neurons, he estimates that there are only 4 million cranial nerves to connect, and 3 million of them come from the retina (the color-coded photoreceptors).

 

Who might volunteer to have their head and spinal cord cut out of their body and their skull removed, to be reborn as a cyborg, fed by an ECMO machine? Many terminally ill cancer patients have not suffered a neurodegenerative disease. Their body will die while the mind is still ripe.

 

I do not believe we will be able to upload our consciousness to a silicon substate, as Ray Kurzweil has long predicted, at least not any time earlier than we will grow an AI that exceeds human intelligence. The brain in a vat is very different. A prosthetic hijacking of the interface to the sensory cortex is a much simpler task. The inscrutable complexity of the cortex remains just that. We just need to couple to the extant external interface to the body.

 

He makes it sound… imminent. While the sensory cortex is notable for its neuroplasticity, (the ability to remodel sensory input), can it be this dramatic — from body to borg?

 

I thought of the adage from Hunter S. Thompson that arose while watching a boxing match on an ether binger: “Kill the body and the head will die.”

 

Thanks to Genevieve being an MIT alumnus, I can get behind the paywall of the MIT Technology Review October issue on the Mind. Professor Lisa Feldman of Northeastern postulates a problem: “Your brain did not evolve to think, feel, and see. It evolved to regulate your body. Your thoughts, feelings, senses, and other mental capacities are consequences of that regulation. Since allostasis [regulation of body systems] is fundamental to everything you do and sense, consider what would happen if you didn’t have a body. A brain born in a vat would have no bodily systems to regulate. It would have no bodily sensations to make sense of. It could not construct value or affect. A disembodied brain would therefore not have a mind. I’m not saying that a mind requires an actual flesh-and-blood body, but I am suggesting that it requires something like a body, full of systems to coordinate efficiently in an ever-changing world. Your body is part of your mind—not in some gauzy, metaphorical way, but in a very real brain-wiring way.

 

Your thoughts and dreams, your emotions, even your experience right now as you read these words, are consequences of a central mission to keep you alive, regulating your body by constructing ad hoc categories. Most likely, you don’t experience your mind in this way, but under the hood (inside the skull), that’s what is happening.”

 

She elaborates, as you might assume: “When your brain remembers, it re-creates bits and pieces of the past and seamlessly combines them. We call this process ‘remembering,’ but it’s really assembling. In fact, your brain may construct the same memory (or, more accurately, what you experience as the same memory) in different ways each time. I’m not speaking here of the conscious experience of remembering something, like recalling your best friend’s face or yesterday’s dinner. I’m speaking of the automatic, unconscious process of looking at an object or a word and instantly knowing what it is. Every act of recognition is a construction. You don’t see with your eyes; you see with your brain. Likewise for all your other senses. Just as your memory is a construction, so are your senses. Everything you see, hear, smell, taste, and feel is the result of some combination of stuff outside and inside your head. Affect is just a quick summary of your brain’s beliefs about the metabolic state of your body, like a barometer reading of sorts.

 

Brains evolved to control bodies. Over evolutionary time, many animals evolved larger bodies with complex internal systems that needed coordination and control. A brain is sort of like a command center to integrate and coordinate those systems. It shuttles necessary resources like water, salt, glucose, and oxygen where and when they are needed. This regulation is called allostasis; it involves anticipating the body’s needs and attempting to meet them before they arise. If your brain does its job well, then through allostasis, the systems of your body get what they need most of the time.

 

To accomplish this critical metabolic balancing act, your brain maintains a model of your body in the world. The model includes conscious stuff, like what you see, think, and feel; actions you perform without thought, like walking; and unconscious stuff outside your awareness. For example, your brain models your body temperature. This model governs your awareness of being warm or cold, automatic acts like wandering into the shade, and unconscious processes like changing your blood flow and opening your pores. In every moment, your brain guesses (on the basis of past experience and sense data) what might happen next inside and outside your body, moves resources around, launches your actions, creates your sensations, and updates its model. This model is your mind, and allostasis is at its core.”

 

Anil Seth from the University of Sussex phrases it more strongly in Our brains exist in a state of controlled hallucination: “The brain is always constructing models of the world to explain and predict incoming information; it updates these models when prediction and the experience we get from our sensory inputs diverge.

 

The entirety of perceptual experience is a neuronal fantasy that remains yoked to the world through a continuous making and remaking of perceptual best guesses, of controlled hallucinations. You could even say that we’re all hallucinating all the time. It’s just that when we agree about our hallucinations, that’s what we call reality.”

 

P.S. photo above is a movie prop from Robocop 2

Reminds me of neuron synapse connections. Looking up at the branches of a pine tree. Happy Sliders Sunday!

Canary Wharf Winter Lights

How Music Affects the Brain bebrainfit.com/music-brain/

 

The Chemistry of Music an the Brain prezi.com/k0jlkpkcqnkt/the-chemistry-of-music-and-the-brain/

 

Ways that Music Affects your Brain and Mood www.consciouslifestylemag.com/music-and-the-brain-affects...

 

Knowing Neurons knowingneurons.com/2017/07/12/music/

 

The Effect of Music on the Production of Neurotransmitters pdf. pdfs.semanticscholar.org/4bfe/35f957b10959f9c9fb063ba0453...

 

the-impact-of-music-on-neurochemistry www.audiocura.com/the-impact-of-music-on-neurochemistry/

  

Free and light thoughts

 

View in balck: View On Black

This is an embryonic nerve cell growing on DNA. In this system DNA is being studied as a tool to dynamically control surface adhesion for cells. Changing the cell behavior at different time intervals allows us to recreate the dynamic growth sequences that occur naturally in regenerating animals like newts.

 

Courtesy of Dr. Mark McClendon , Northwestern University

 

Image Details

Instrument used: Quanta SEM

Magnification: 8,000X

Horizontal Field Width: 20um

Vacuum: 2 e-3Pa

Voltage: 3kV

Spot: 3

Working Distance: 6

Detector: SE

 

When you look closely at the foam, you will discover this amasing structures.

Fotografia e Tratamento: Jackson Carvalho

Assistentes de Fotografia: Gustavo Almeida e João Lucas

www.artedigitalstudio.com.br

© 2013, Todos os Direitos Reservados

Description: Illustration of neuron with dendrites and nucleus

 

Credit: National Institutes of Health, National Institute of Mental Health

Taken @ Bangalore .. Near vidhana soudha..

Hippocampus and neurons of mouse with the neurodegenerative disease Niemann-Pick type C1. Credit: I. Williams, NICHD

I was organizing a photo workshop didn;t take any good photo for what I set out but opened the window and had this sunset in front of me.

A brain coral. Just like our brains, a network of individuals creating one individual.

Building on his first book, On Intelligence, Jeff bravely presents a framework for how the brain works to produce intelligence from neurons organized into ~150 thousand cortical columns.

 

His decades of self-funded dedication to studying how the brain works affords a possibly unique and unifying perspective. In both books, though, he loses his way when speculating on the artificial brains of the future (with logical inconsistencies and overgeneralizations anchored on our biology). I think the first 112 pages are the best part of his new book. I’ll focus on that and save a brief critique of his AI constraints for the end.

 

In his first book, Hawkins presents a memory-prediction framework for intelligence. The neurons in the neocortex provide a vast amount of memory that learns a model of the world. These models continuously make low-level predictions in parallel across all of our senses. We only notice them when a prediction is incorrect. Higher in the hierarchy, we make predictions at higher levels of abstraction (the crux of intelligence, creativity and all that we consider being human), but the structures are fundamentally the same.

 

If that is not mind-bending enough, in his new book, Jeff extends the memory framework to the construct of “reference frames”. Everything we perceive is a constructed reality, a cortical consensus from competing internal models resident in many cortical columns, the amalgam of 1000 brains. Those models are updated by data streaming from the senses. But our reality resides in the models.

 

Here are the best parts of his new book, in my opinion. I revisit them to learn. Travelling without moving, as we’ll see…

 

“The cells in your head are reading these words. Think how remarkable that is.”

 

“If you ignore folds and creases, then the neocortex looks like one large sheet of cells, with no obvious divisions. The neocortex looks similar everywhere. Every part of the neocortex generates movement. In every region we have examined, scientists have found cells that project to some part of the old brain related to movement. The complex circuitry seen everywhere in the neocortex performs a sensory-motor task. There are no pure motor regions and no pure sensory regions.”

 

The cortex is relatively new development by evolutionary time scales. After a long period of simple reflexes and reptilian instincts, only mammals evolved a neocortex. “At some point millions of years ago, a new piece of the brain appears that we now call the neocortex. It starts small, but then grows larger, not by creating anything new, but by copying a basic circuit over and over. As the neocortex grows, it gets larger in area but not in thickness.” Given the recency, it’s “probably not enough time for multiple new complex capabilities to be discovered by evolution, but it’s plenty of time for evolution to make more copies of the same thing.”

 

• Vernon Mountcastle’s proposition from 1978: “All the things we associate with intelligence, which on the surface appear to be different, are, in reality, manifestations of the same underlying cortical algorithm. Darwin proposed that the diversity of life is due to one basic algorithm (evolution). Mountcastle proposed that the diversity of intelligence is due to one basic algorithm.”

 

Beyond the evolutionary time-scale argument, the brains’ vast flexibility to accept different, even prosthetic, sensory input changes and its ability to learn many different things point to a universal framework for learning.

 

• Cortical Columns are “the largest and most important piece of the puzzle.” They are roughly one square millimeter in size with 100K neurons. A mouse has one column per whisker. “Every cortical column is making predictions. We are not aware of the vast majority of these predictions unless the input to the brain does not match.”

 

• Learning through movement: “The brain learns its model of the world by observing how its inputs change over time. There isn’t another way to learn. Every time we take a step, move a limb, move our eyes, tilt our head, or utter a sound, the input from our sensors change. For example, our eyes make rapid movements, called saccades, about three times a second. With each saccade, our eyes fixate on a new point in the world and the information from the eyes to the brain changes completely.” We don’t perceive any of this because we are living in the model, which is predicting the next input to come, across all the senses. “Vision is an interactive process, dependent on movement. Only by moving can we learn a model of the object.”

 

“To avoid hallucinating, the brain needs to keep its predictions separate from reality. We are not aware of most of the predictions made by the brain unless an error occurs.”

 

“Thoughts and experiences are always the result of a set of neurons that are active at the same time (about 2% of the total). Individual neurons can participate in many different thoughts or experiences. Everything we know is stored in the connections between neurons. Every day, many of the synapses on an individual neuron will disappear and new ones will replace them. Thus, much of learning occurs by forming new connections between neurons that were not previously connected.”

 

Sequence memory (like predicting the next note in a melody or a common sequence of behaviors): “Sequence memory is also used for language. Recognizing a spoken work is like recognizing a short melody.”

 

• Locus of Predictions: “Oddly, less than 10% of the pyramidal cell’s synapses are in the proximal area. The other 90% are too far away to trigger a spike. For many years, no one knew what 90% of the synapses in the neocortex did. The big insight I had was that dendrite spikes are predictions. A dendrite spike occurs when a set of synapses close to each other on a distal dendrite get input at the same time, and it means the neuron had recognized a pattern of activity in some other neurons. When the pattern of activity is detected, it raises the voltage at the cell body, putting the cell into what we call a predictive state. The cell is primed to spike… and the cell spikes a little bit sooner than if it would have if the neuron was not in a predictive state.” And this inhibits other neurons from ever firing, the ones who were behind in that race. “When an input arrives that is unexpected, then neurons fire at once. If the input is predicted, then only the predictive-state neurons become active. This is a common observation about the neocortex: unexpected inputs cause a lot more activity than expected ones.” Predictions prime the pump, sub-threshold. “Predictions are not sent along a cell’s axon to other neurons, which explains why we are unaware of most of them.”

 

“Most predictions occur inside neurons. With thousands of distal synapses, each neuron can recognize hundreds of patterns that predict when the neuron should become active. Prediction is built into the fabric of the neocortex. As few as 20,000 neurons can learn thousands of complete sequences. The sequence memory continued to work even if 30% of the neurons died or the input was noisy.”

 

• Reference Frames: “The secret of the cortical column is reference frames. A reference frame is like an invisible, 3D-grid surrounding and attached to something” (like a map)

 

“Predicting the next input in a sequence and predicting the next input when we move are similar problems. Our sequence-memory circuit could make both types of predictions if the neurons were given an additional input that represented how the sensor was moving.”

 

“Most of the circuitry is there to create reference frames and track locations. The brain builds models of the world by associating sensory input with locations in reference frames. You need a reference frame to specify the relative position and structure of objects. Roboticists rely on them to plan the movements of a robot’s arm or body. Reference frames were the missing ingredient, the key to unraveling the mystery of the neocortex and to understanding intelligence. We showed that a single cortical column could learn the 3D shape of objects by sensing and moving and sensing and moving. Each cortical column must know the location of its input relative to the object being sensed. To do that, a cortical column requires a reference frame that is fixed to the object. The brain must have neurons whose activity represents the location of every object that we perceive.”

 

“Mammals have a powerful internal navigation system. There are neurons in the old part of our brain that are known to learn maps of the places we have visited” — the hippocampus and enthorhinal cortex, organs roughly the size of a finger.

 

“Place cells tell a rat where it is based on sensory inputs, but planning movement requires grid cells. Grid cells form a grid pattern. The two types of cells work together to create a complete model of the rat’s environment. Every time a rat enters an environment, the grid cells create a new reference frame to specify locations and plan movements.” In the new brain, these same cells and structures create models of objects instead of environments.

 

“Every cortical column learns models of complete objects. The columns do this using the same basic method that the old brain uses to learn models of environments. It is as if nature stripped down the hippocampus to a minimal form, made tens of thousands of copies, and arranged them side by side in cortical columns. That became the neocortex. Each patch of your skin and each patch of your retina has its own reference frame in the neocortex. Your five fingertips touching a cup are like five rats exploring a box.”

 

“Not all cortical columns are modeling objects. Language and other high-level cognitive abilities are, at some fundamental level, the same as seeing, touching, and hearing. The reference frames that are most useful for certain concepts have more than three dimensions.”

 

• Thinking is a form of movement: “The brain arranges all knowledge using reference frames, and thinking is a form of moving. Thinking occurs when we activate successive locations in reference frames.”

 

“A cortical column is just a mechanism that tries to discover and model the structure of whatever is causing its inputs to change” whether the structure of environments, physical objects or conceptual objects. “Reference frames are not an optional component of intelligence; they are the structure in which all information is stored in the brain. Every fact you know is paired with a location in a reference frame. Organizing knowledge this way makes the facts actionable” to “determine what actions are needed to achieve a goal.”

 

“To recall stored knowledge, we have to activate the appropriate locations in the appropriate reference frames. Thinking occurs when the neurons invoke location after location in a reference frame, bringing to mind what was stored in each location. The succession of thoughts we experience when thinking is analogous to the succession of sensations we experience when touching an object with a finger, or the succession of things we see when we walk about a town.”

 

• What and Where Pathways. “Your brain has two vision systems. If you follow the optic nerve as it travels from the eye to the neocortex, you will see that it leads to two parallel vision systems, called the ‘what’ visual pathway and the ‘where’ visual pathway.” If you disable one, you can identify what something is but not where, or vice versa. “Similar pathways also exist for other senses. There are what and where regions for seeing, touching, and hearing.”

 

“Cortical grid cells in What columns attach reference frames to objects. Cortical grid cells in Where columns attach reference frames to you body.” The distinction depends on where the inputs come from. “If a cortical column gets input from the body, such as the neurons that detect the joint angles of the limbs, it will automatically create a reference frame anchored to the body.”

 

“Your body is just another object in the world. However, unlike external objects, your body is always present. A significant portion of the neocortex — the Where regions — is dedicated to modeling your body and the space around your body.”

 

For abstract concepts like mathematics, there are difference reference frames one could use to learn. “Part of learning is discovering what is a good reference frame, including the number of dimensions.” History can be learned on a timeline, or geographically. “They lead to different ways of thinking about history. They might lead to different conclusions and different predictions. Becoming an expert in a field of study requires discovering a good framework to represent the associated data and facts. Discovering a useful reference frame is most difficult part of learning, even though most of the time we are not consciously aware of it. The correct reference frame to understand how the brain works is reference frames.” It's no surprise that the memory trick called the method of loci, or memory palace, is a good method for remembering a large sequential list of nouns.

 

From fMRI studies, “the process of storing items in a reference frame and recalling them via ‘movement’ is the same.”

 

“Nested structure and recursion are key attributes of language. Each cortical column has to be able to learn nested and recursive structure. Cortical columns create reference frames for every object they know. Reference frames are then populated with links to other reference frames. The brain models the world using reference frames that are populated with reference frames; it’s reference frames all the way down.”

 

• The Thousand Brains Theory of Intelligence: The prevailing view of the neocortex was a hierarchy of feature detectors, from edge detectors up to face detectors. Jeff argues that each and every column is a sensory-motor system. “When the eyes saccade from one fixation point to another, some of the neurons in the V1 and V2 visual regions do something remarkable. They seem to know what they will be seeing before the eyes have stopped moving. These neurons become active as if they can see new input, but the input hasn’t yet arrived. There are connections between low-level visual regions and low-level touch regions.” Mouse vision occurs in the V1 region; it does not depend on a hierarchy of vision abstractions.

 

“All cortical columns, even in low-level sensory regions, are capable of learning and recognizing complete objects. A column that senses only a small part of an object (e.g., from a patch of retina) can learn a model of the entire object by integrating its inputs over time.”

 

“Learning is not a separate process from sensing and acting. We learn continuously. When a neuron learns a new pattern, it forms new synapses on one dendrite branch. The new synapses don’t affect previously learned ones on other branches. Thus, learning doesn’t force the neuron to forget or modify something it learned earlier.” It’s additive.

 

“What a column learns is limited by its inputs. Columns in V1 can recognize letters and words in the smallest font. V1 and V2 learn models of objects, such as letters and words, but the models differ by scale.”

 

“Knowledge of something is distributed in thousands of columns, but these are a small subset of all the columns. This is why we call it the Thousand Brains Theory: knowledge of any particular item is distributed among thousands of complimentary models. The columns are not redundant, and each is a complete sensory-motor system.”

 

• The Solution to Sensor Fusion and the Binding Problem: “Columns vote. Your perception is the consensus the columns reach by voting.”

 

“If you touch something with only one finger, then you have to move it to recognize the object. But if you grasp the object with your entire hand, then you can usually recognize the object at once. In almost all cases, using five fingers will require less movement than using one.” (made me think of reading Braille with multiple fingers). “Voting works across sensory modalities (sight, touch, etc.)”

 

How? “Cells in some layers send axons long distances within the neocortex” between left and right-hand brain regions or between V1 and A1, the primary vision and auditory regions. “These cells with long-distance connections are voting. Cells that represent what object is being sensed can vote and will project broadly. Often a column will be uncertain, in which case its neurons will send multiple possibilities at the same time. Simultaneously, the column receives projections from other columns representing their guesses. The most common guesses suppress the least common ones until the entire network settles on one answer. The voting mechanism works well even if the long-distance axons connect to a small, randomly chosen subset of other columns”

 

• The Stability of Perception with ever-changing inputs: “What we perceive is based on the stable voting neurons. We are not consciously aware of the changing activity in each column.” Roughly 98% are silent at any given time and 2% are continuously firing. Consider the experience of an optical illusion duality (like the drawing of a pair of faces or vase); you can only see one at a time, and there is a delay if you force yourself to switch. “Recognizing an object in one sensory modality leads to predictions in other sensory modalities.”

 

• Attention: We have the perception of multiple objects in our visual field even though we can only attend to one at a time. “Attention plays an essential role in how the brain learns models. The brain can attend to smaller or larger parts of the visual field. Exactly how the brain does this is not well understood, but it involves a part of the brain called the thalamus, which is tightly connected to all areas of the neocortex. It is so intimately connected to the neocortex that I consider it an extension of the neocortex.”

 

• Consciousness: “Neurons form a continuous memory of both our thoughts and actions. It is this accessibility of the past — the ability to jump back in time and slide forward again to the present — that gives us our sense of presence and awareness. This is the core of what it means to be conscious. If we couldn’t replay our recent thoughts and experiences, then we would be unaware we are alive.”

 

“The neocortex does not directly control any muscles. The neocortex has to be attached to something that already has sensors and already has behaviors (the primitive brain). It does not create completely new behaviors; it learns how to string together existing ones in new and useful ways.”

 

“Instead of the neocortex using a hierarchy to assemble features into a recognized object, it uses hierarchy to assemble objects into more complex objects.” The assumption of hierarchy has been stumbling block for neuroscience for many decades.

 

“Reverse engineering the brain and understanding intelligence is the most important scientific quest humans will ever undertake. At one point I debated whether I should end right there. A framework for understanding the neocortex is certainly ambitious enough for one book.”

 

Yes, perhaps he should have. AI has been his failing. And, more abstractly, it is one of the grand challenges of biomimicry. While the brain provides the existence proof of an iterative algorithm compounding complexity and generating intelligence, it is a non-trivial exercise to capture the right level of abstraction when instantiating on a silicon substrate. Jeff seems to anchor on our biology to the point of having the wrong reference frame, so to speak, for his intuition. He asserts that certain aspects of our biology must be replicated in all artificial intelligences (e.g., a physically moving vision sensor vs a raster scan saccade) while dismissing countless other aspects of our biology, from ion channels to the goal setting regions of the brain.

 

We can logically see many idiosyncratic limitations in our biology, constrained by cellular sensors and compute, and need not replicate them in silicon. Similarly, there are limits in our silicon substrates (e.g., number of metal layers and lack of dynamic interconnect) that we need to address if synaptic fanout and long-range voting circuits are fundamental elements.

 

He is not alone is anchoring on the wrong elements of biomimicry. Neuromorphic spiking compute comes to mind. And this is why I did not even present his AI arguments, as they seemed so riddled with misguided leaps of intuition. You can see how he lost his way in his first book when he asserted that we could generate an AI, and then cut and paste key blocks of functionality like the ability to speak French from one AI to another.

 

Nevertheless, I am curious about his self-funded work on the brain, which might be a meaningful contribution on the biological side.

“Her Dream Became a Nightmare as She Probed the Alien Ruins.”

 

From the back cover:

 

The human personality has been defined by leading psychologists as the integrated and dynamic organization of physical, mental, moral and social qualities. A personality is the product of heredity and environment. Every experience records itself in the neurons of the brain producing an almost infinite number of possible combinations. Brains are as individual as fingerprints.

 

In an infinite universe, however, there is a possibility that somewhere – separated by vast distances of Time and Space – two exactly similar brains exist. The strange telepathic bond between identical twins could operate between identical minds.

 

Melinda Tracey was a practical, intelligent, modern girl who didn’t believe in dreams – even recurring dreams – but her odd sleep experiences of the ruined city, and the strangely-suited figure who searched it, disturbed her considerably.

 

What incredible psychological bond linked Melinda to the lonely stranger, probing the wreckage of an alien metropolis?

 

---------------------------------------------------

 

Badger Books were published between 1959 and 1967 in a number of genres, predominantly war, westerns, romance, supernatural and science fiction. In common with other “pulp” or mass-market publishers of the time, Badger Books focused on quantity rather than quality. A new title in each of the major genres appeared each month, generally written to tight deadlines by low-paid authors. One of the most remarkable facts about Badger Books is that much of its output was produced by just two authors (using a range of house names and other pseudonyms). John Glasby (over 300 novels and short stories) and Robert Lionel Fanthorpe (over 200 novels and stories). [Wikipedia]

 

Scientists have been developing astounding new tools for exploring neural circuits that underlie brain function throughout the first five years of the National Institutes of Health’s Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative. Now, the NIH has announced its continued support for these projects by funding over 180 new BRAIN Initiative awards, bringing the total 2019 budget for the program to more than $424 million.

 

Learn more: www.nih.gov/news-events/news-releases/new-nih-brain-initi...

 

Credit: Leterrier, NeuroCyto Lab, INP, Marseille, France

A team at Harvard University created this image from "The Beautiful Brain", at the Weisman Art Museum. Check sounds at below links.

www.minnesotamonthly.com/Lists-Guides/Things-To-Do/The-Be... Art and neuroscience.

www.blakeporterneuro.com/science/laboratory-teaching-reso... Sounds of the Brain-Neurons and Rythms.

from slide 21 of this excellent presentation by v s ramachandran

 

hosted.mediasite.com/hosted5/Viewer/?peid=d45a2cd8e48346d...

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