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OpenKick Technologies - The Drupal and Ruby on Rails Training and Business Incubation division of Gloscon
Changing Drupal layout options could be easy as the Flickr.
Permissions could be admin only (primarily) and also per/user (secondarily, though not necessary)
Currently for Drupal the layout options handled with theming + myriad of modules; Panels, Views, CCK filed options, Composite etc. but there is no a core approach to it
A core layout.module api and all other modules strip of theming/layout functions and using layout api might be a solution