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Grand Case, St. Martin. A lolo is a small restaurant that grills food and serves it cheap. There are five of them in the center of Grand Case right on the water. You'll get plastic cutlery and paper napkins and the air conditioning is only with the wonderful smells of grilled meat.
Usina de energia eólica, Serra Catarinense, Bom Jardim da Serra - Brasil.
Eduardo Pasqualini Fotografias - Fotógrafo em Rio do Sul, Santa Catarina, Brasil.
this bag is made with wald baskets in mind - specifically the wald 137. It just so happens to fit into the velo orange porteur rack with rail nice and snug...
June 2010. "Great Paul" bell case outside Loughborough Town Hall. The bell was made at Taylors bell foundry in the town in 1881 for St Pauls cathedral. This case should be on display in the Queens Park April 2013.
Hey! If you would be so kind to check out my iPhone cases at
www.etsy.com/shop/PhoneCases?ref=seller_info
It features my photography so I thought Flickr would be a good place to post this. Happy Holidays!
Case this Sketch--Sketch #66
Supplies Used:
Clockwork Stencil (Tim Holtz) - Stampers Anonymous
Train schedule background from Wendy Vecchi's "Metro Art" set by Stampers Anonymous
Iced Spruce, Rusty Hinge Distress Inks - Ranger
"Miss you" sentiment from the "All the Time" set by Hero Arts
I placed the stencil on top of a piece of white cardstock and applied Distress inks over the top of the stencil and then stamped the background with the stencil still in place.
This month's Muse over at CASE Study is none other than the uber talented Joy Taylor. I didn't get a chance to play in last weeks challenge.... but this weeks card is just stunning. Here's my take on it.
I used one of the Hero Arts/BasicGrey borders set with Hero Arts Stone Wash mid tone inkto replicate Joy's die cut border. I used a butterfly ( die cut sent to me by Arlene) and a handmade watercolour flower. The sentiment is also from a Hero Arts set, stamped in Memento Danube Blue ink.
Object Name: Tall case clock
Accession Number: HF.85.139.1
Date: c. 1830
Materials: Mahogany
Origin: Prince Edward Island
Artist/Manufacturer: John Trenaman
Description: A Georgian style tall case clock made by Charlottetown clockmaker, John Trenaman. Clock face has images of the eastern and western hemispheres as well as a roundel to display seconds and days of the month. Clock face is framed by swan-neck pediment. Both the clock face and its mechanics are imported.
www.yahoo.com/news/wsu-researchers-discover-vaccine-resis...
WSU researchers discover vaccine-resistant, COVID-like virus ‘likely capable of infecting humans’
A team led by researchers from Washington State University’s Paul G. Allen School for Global Health has discovered a virus in a Russian bat similar to the virus behind COVID-19 that is “likely capable of infecting humans” and would be resistant to current vaccines, according to a news release.
Researchers discovered that the virus – which they are dubbing Khosta-2 – could be capable of infecting humans, and was resistant to antibodies produced by the COVID-19 vaccine.
Both Khosta-2 and SARS-CoV-2, the virus behind COVID-19, belong to the same subcategory of coronaviruses.
“Our research further demonstrates that sarbecoviruses circulating in wildlife outside of Asia — even in places like western Russia where the Khosta-2 virus was found — also pose a threat to global health and ongoing vaccine campaigns against SARS-CoV-2,” said Michael Letko, WSU virologist and corresponding author of the study.
Letko stressed how this gives us further proof of the importance of universal vaccines against respiratory viruses, instead of focusing specifically on COVID-19 variant strains.
“Unfortunately, many of our current vaccines are designed for specific viruses we know infect human cells or those that seem to pose the biggest risk to infect us. But that is a list that’s ever-changing,” Letko said. “We need to broaden the design of these vaccines to protect against all sarbecoviruses.”
When the Khosta-1 and Khosta-2 viruses were originally discovered in Russian bats in late 2020, it was thought that they posed no threat to humans. But researchers learned that, like SARS-CoV-2, Khosta-2 can use its spike protein to infect cells by attaching to a receptor protein found throughout human cells.
Then, using a serum made from blood samples of people vaccinated against COVID-19, the researchers saw that Khosta-2 was not neutralized by the vaccines.
Letko did say that the virus lacks some of the genes that are believed to be involved in disease development in humans, but that there is a risk of it recombining with a virus like SARS-CoV-2.
“When you see SARS-2 has this ability to spill back from humans and into wildlife, and then there are other viruses like Khosta-2 waiting in those animals with these properties we really don’t want them to have, it sets up this scenario where you keep rolling the dice until they combine to make a potentially riskier virus,” Letko said.
www.yahoo.com/news/scientists-coronavirus-bats-resistant-...
Scientists Find a New Coronavirus in Bats That Is Resistant to Current Vaccines
It’s the news that public health experts expect but dread: virus-hunting researchers have discovered a new coronavirus in bats that could spell trouble for the human population. The virus can infect human cells and is already able to skirt the immune protection from COVID-19 vaccines.
Reporting in the journal PLoS Pathogens, scientists led by Michael Letko, assistant professor in the Paul Allen School of Public Health at Washington State University, found a group of coronaviruses similar to SARS-CoV-2 that were initially discovered living in bats in Russia in 2020. At the time, scientists did not think the virus, called Khosta-2, posed a threat to people.
But when Letko’s team did a more careful analysis, they found that the virus could infect human cells in the lab, the first warning sign that it could become a possible public health threat. A related virus also found in the Russian bats, Khosta-1, could not enter human cells readily, but Khosta-2 could. Khosta-2 attaches to the same protein, ACE2, that SARS-CoV-2 uses to penetrate human cells. “Receptors on human cells are the way that viruses get into cells,” says Letko. “If a virus can’t get in the door, then it can’t get into the cell, and it’s difficult to establish any type of infection.”
Khosta-2 doesn’t appear to have that problem, since it seems to infect human cells readily. Even more troubling, when Letko combined serum from people who have been vaccinated against COVID-19 with Khosta-2, the antibodies in the serum did not neutralize the virus. The same thing happened when they combined the Khosta-2 virus with serum from people who had recovered from Omicron infections.
“We don’t want to scare anybody and say this is a completely vaccine-resistant virus,” Letko says. “But it is concerning that there are viruses circulating in nature that have these properties—they can bind to human receptors and are not so neutralized by current vaccine responses.”
The good news is that Letko’s studies show that, like the Omicron variant of SARS-CoV-2, Khosta-2 does not seem to have genes that would suggest it could cause serious disease in people. But that could change if Khosta-2 starts circulating more widely and mixing with genes from SARS-CoV-2. “One of the things we’re worried about is that when related coronaviruses get into the same animal, and into the same cells, then they can recombine and out comes a new virus,” says Letko. “The worry is that SARS-CoV-2 could spill back over to animals infected with something like Khosta-2 and recombine and then infect human cells. They could be resistant to vaccine-immunity and also have some more virulent factors. What the chances of that are, who knows. But it could in theory happen during a recombination event.”
It’s a sobering reminder that pathogens are ready and waiting to jump from any number of animal species into humans. And in many cases, as with SARS-CoV-2, these microbes will be new to people and therefore encounter little resistance in the form of immunity against them. “These viruses are really widespread everywhere, and are going to continue to be an issue for humans in general,” says Letko.
The findings come as the World Health Organization’s (WHO) ACT—Accelerator’s Council Tracking and Accelerating Progress—working group report that continued response to the COVID-19 pandemic, in the form of testing, vaccinations, and treatments, is stalling. With lower global immunity to the current SARS-CoV-2 virus, combating any new pathogens, including new coronaviruses like Khosta-2, would become more difficult. According to the latest data collected by the WHO, a quarter of people around the world still have not received a primary series of COVID-19 vaccination.
Ultimately, having deeper dossiers on the microbial world, especially information on how well certain viruses can infect human cells, for example, will be important to making the response to public health threats more efficient and more powerful. Letko is working on building a database that includes information on which human receptors viruses use to infect cells, and whether or not those viruses can evade existing vaccines. That way, he says, when new microbes are discovered that are similar to those in the database, researchers could have a head start on understanding how to control them. “At some point in the future, as these outbreaks continue, we won’t have to scramble whenever a new virus spills over into people,” he says. “We could plug the virus into the database, and understand that it probably uses these receptors to get into human cells, and might be resistant to these types of vaccines or treatments. It’s a 10- to 20-year goal, but it’s possible. It’s not just a pipe dream.”
This thing chops, blocks rocks etc. and does the dishes.
Look at these prices!!! www.tractorhouse.com/listings/forsale/list.asp?man=CASE+I...
www.farmcountrytrader.com/Search/Details.cfm?IID=8609667
Taken through car window.