Perception photos on Flickr

The was previously labled as Minneapolis, Snow and Dread. When I was taking these, it had to be about 5:30am or 6:00 am, and spent the entire night writing of my travel experience up to that point (by hand, with a bad pen - difficult when one is so used to typing). This was actually taken in Detroit...

So, fellow flickrite Autntie K pointed me to the JPG Mag group after seeing this image. The story behind it follows.

on my recent trip back home, I had a hop skip and jump through a few airports (ABQ, MSP, DTW, TOL). I wont' go into the grimy details, save for Sunday morning in DTW. I arrived at the hub about 4 hours early for my flight (had an overnight layover) just in case security gave me a hassle - plus, if I had gone to sleep so late, there's no way I would have woke up time. Anyhow, with so much time at the airport, I figured I'd saunter around and get some flicks.

Of course, I am aware of the issue of cameras, security, airports and all that - and I expected to be chastised at least once while shooting. But, I pretty much had my way with the place for a good hour or so before people started piling in. I didn't shoot anything spectacular, in fact, I think this was probably my "best" image of the morning. I also didn't go anywhere out of the way to get an image: I was as obvious as one could be. Anyhow, after blowing off about 70 or so images, I found my gate, and made a comfortable spot on the benches to relax on before my flight left. Just as I leaned my head back and closed my eyes, I noticed that I was now reclining in the shadow of a rather tall figure: A Detroit Police officer. He introduced himself in a polite manner, advised me that 'others' had called him to notify that there was some character running about the airport snapping photos. Then he asked just what I was shooting that made eveyrone so nervous. Indeed. Meanwhile, in the background, the gentle female voice recording echoes through the concourse: "...If you see anyone acting suspicious, or notice any suspicious behavior, please don't hesitate to contact security or an airport employee..."

I told him that I couldn't really tell what it was that I shot that made anyone nervous, and that I was just shooting whatever I though was interesting: piles of wheelchairs, empty concourses that are usually full, myself, blah blah. He asked me the same question again, but worded it differently - and I told him the camera was digital, and offered to show him the photos. He declined, but did ask for my ID, took my name and all that, checked for warrants. I asked if I was not supposed to be shooting images in the airport, and that I did not see any signs, and that the TSA drones didn't warn me about anything either. His only response was that he had to check it out because it was called in, and that if we weren't allowed to shoot in the facility, TSA wouldn't let the cameras through in the first place.

So, was I hassled? Not really, other than missing 10 or 15 minutes of pseudo napping. The lawman was very cordial in his manner, and I was the same in my response. I suppose it could have gotten ugly if A: he had a chip on his shoulder, or B: I had a chip on my shoulder. I got the feeling that he would have rather not had to deal with me, and was doing so only to appease the frightened masses ;) or whoever it was that called in.

Funny is that just after I entered the airport, I saw a young couple in front of me, and they were shooting images also. They had a smallish, silver, square looking Sony something or other (I had my Digital Rebel, with vertical grip), and we took turns shooting down a particular hallway in order to stay out of eachothers photos. I doubt they were interviewed though. But, I also understand why (sort of).

My experience was a pretty benign situation, to be sure. But I've read through the posts on jpgmag, as well as seen several news items in the last few years about the subject. I understand the whole security thing, but don't agree with the hammer dropping on photographers like it has. People are way too afraid, and common sense often times goes out the window when fear takes over. My favorite thing I've read in the forum here was something like "Terrorists used cell phones, why not ban them?". I don't think it's so much about safety/security as it is about the perception of security. Anyhow, just thought I'd share that, and the one of the pics I made that instigated the story...

Business cards Perception by Bas Bakker

Business cards Perception

Perception by Arvinelle Beck

Visit this location at The Cuckolding Wife - A Hotwife, Bull and Cuckold Resort in Second Life

PERCEPTION by Charles Wills

A short film

Sunset at the beach? by yona garrett

View of the moon from my porch.

"The Grand Illusion'" by Halvorsong

In the aftermath of tornadoes, a rendered phone-pole appears to levitate, defying perception -- and boggling the mind.

Nashville, Tennessee.

PERCEPTION by Charles Wills

A short film

Perception by Mz KhrysSL

Its always about the view

perceptions by penny volpe

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Perception by Melissa erboristeria con salotto

Prezzo: 13,00€

Verde mirto.

Un bellissimo tono diverso da tutti quelli mai provati.

Esclusivo pennello per una stesura perfetta e duratura.

Gli smalti Faby sono 10 Free, realizzati senza Formaldeide, Toluene, Diphtilftalato (Dbp), Canfora, Resina Formaldeide, Ethil Tosylamide, Trifenilfosfato (Tphp), Acetone, Parabeni e Piombo. 100% Vegan. Non testato sugli animali. Ciascun colore è nel formato da 15 ml. Finish cream.

The third ray of creative intelligence by Ale Di Gangi

10 11

Green is a color, the perception of which is evoked by light having a spectrum dominated by energy with a wavelength of roughly 520–570 nm.

The word green is closely related to the Old English verb growan, “to grow”. It is used to describe plants or the ocean. Sometimes it can also describe someone who is inexperienced, jealous, or sick. In America, green is a slang term for money, among other things. Several colloquialisms have derived from these meanings.

By far the largest contributor to green in nature is chlorophyll, the chemical by which plants photosynthesize. Many animals have adapted to their green environments by taking on a green hue themselves as camouflage.

In human culture, green has broad, even contradictory meanings.

(this and much more from Wikipedia; meaning of the title explained in this paragraph)

featuring sabe81, aka elisabetta

I put videos I create on Vimeo. You can see them there

Depth of Perception by Alan Levine

Depth of Perception

Dynamic Perception Dolly in action by Morten Berg

This is a behind the scenes shot from my debut timelapse film:

vimeo.com/31897918

www.youtube.com/watch?v=nap-Dzfjpu0

perception 29 by francesco X

PERCEPTION by Charles Wills

A short film

evolving perceptions by darlene charneco

6 3

'Evolving Perceptions' 2011

resin, nails, enamel, acrylic on wood 24"x24"

The world is full of magic things,

patiently waiting

for our senses to grow sharper.

~W.B. Yeats

in SENSORIA at art sites April 6th-May 5th 2013

www.flickr.com/photos/avadarlene/8571142256/in/photostream

World leader Fangruida: The 2022 Russian-Ukrainian War (bick.S 2022) by mids les

World Leader International Leader Fang Ruida on World Peace and War - World War III, Nuclear War, Space War (Bic. S 2021v.1.2 2022v.13 revised version, multilingual comparison of the global network version) once the edition came out, immediately got the praise of readers and netizens around the world. In order to meet the needs of hundreds of millions of people, the author has revised and republished it for the benefit of readers and netizens.

Bick. S

Fang Ruida, leader international mondial, parle de la paix mondiale et de la guerre - Troisième Guerre mondiale, guerre nucléaire, guerre spatiale (Bic. S 2021v.1.2 2022v.13 version révisée, comparaison multilingue de la version du réseau mondial) une fois l’édition sortie, a immédiatement reçu les éloges des lecteurs et des internautes du monde entier. Afin de répondre aux besoins de centaines de millions de personnes, l’auteur l’a révisé et republié au profit des lecteurs et des internautes.

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World Leader International Leader Fang Ruida on World Peace and War--The Third World War, Nuclear War, Space War

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In the 20th century, science and technology have been highly developed, social productivity has advanced by leaps and bounds, and the modern civilization and free rational cognitive perception of human society have gradually developed and changed. Human society has opened up a new planetary civilization, which is an inevitable trend of history. Of course, today's human society also It presents various crises and challenges, clashes of civilizations, geopolitics, territorial disputes, spheres of influence, fetishism, political and economic systems, economic models, etc. as well as climate change, resource environment, population growth, wealth gap, plague Viruses, natural disasters, religious beliefs, racial discrimination, vicious competition, even armed war or nuclear war, etc. Countries such as the United States, China, Russia, Europe, India and Pakistan are among them. Without contradiction and competition, there would be no world, and similarly, without peace and compromise There will be no world if you share wealth with each other. Take one step or two steps back, and the sky will be vast. Nuclear weapons are very powerful and worth mentioning. However, the competition between countries and ethnic groups, in the final analysis, mainly lies in economic and political civilization, and of course also includes land, population, resources, etc. Culture, technology, military, influence, sphere of influence, etc. War is just an important unconventional form, just like animal fighting and killing. However, whether animal groups fight inside or outside, there is also considerable compromise and sharing. Otherwise, Animal species groups will also completely disappear or perish. The same is true for the evolutionary history of human society. There is no doubt about it. Whether you are a politician, a military strategist, or a philosopher, a thinker or a sociologist, Anthropologists, no exception.

After World War II, the world formed a Cold War situation: the two major military organizations, the North Atlantic Treaty Organization (NATO) and the Warsaw Pact Organization (Warsaw Pact), began to expand their arms and prepare for war. The United States and the Soviet Union launched an arms race and had nuclear weapons reserves. Vulnerable states will rely on the military protection of great powers as a way to maintain their own security.

The phrase World War III began to appear in communiqués between leaders of various countries. With a large number of high-tech applications in the military field, especially the extensive development and proliferation of nuclear weapons, people have provided a great space for the imagination of the third world war: some people think that the third world war will be a scale that spreads all over the world. The world's nuclear war, this war will become the greatest catastrophe in the history of human civilization. The Cuban Missile Crisis in 1962 was once considered the closest crisis in human history to World War III: a confrontation between two powers with unprecedented nuclear power that lasted for decades in the Caribbean Sea. Although the incident was resolved smoothly, full-scale nuclear war has since become a nickname for World War III.

With the development of the world, more and more people believe that the third world war will become a historical term that will never appear, or a war that will not happen in a visible period of time, all because of the balance of power between the United States and the Soviet Union. And implement a policy of mutually assured destruction so that war does not break out.

The Third World War is an imaginary large-scale war in the next world. During the Cold War between the United States and the Soviet Union, if a war broke out between the two sides, its seriousness could be called the Third World War, but fortunately, both sides tried their best to War was avoided, and neither side broke out until the end of the Cold War. So far, the three wars have only been speculated and imagined, and they have not broken out, but once they break out, they will seriously affect everyone on the earth. After the great ordeal of the Cold War, the Soviet Union yearned for peace and opposed war.

With a large number of high-tech applications in the military field, especially the extensive development and proliferation of nuclear weapons, people have provided great space for the imagination of the third world war - some people believe that the third world war will be a large-scale The nuclear war in the world will become the greatest catastrophe in the history of human civilization. Among them, the Cuban Missile Crisis in 1962 was once considered to be the crisis closest to the Third World War in human history - the confrontation between two great powers with unprecedented nuclear forces in the Caribbean Sea lasted for dozens of days, bringing the possibility of war to the ground. Raised to unprecedented heights.

From different perspectives, there are many reasons for the outbreak of the Third World War, and the government and the people have different views, such as the war launched by the former Soviet Union against the West, the rise of China, and the war in the Middle East.

There are many different reasons for the outbreak of wars, and the camps are also different. It is believed that some countries will use the atomic bomb, and the war may extend into space. The war broke out because, for example, the United States suppressed a rising China. Military conflict between India, Vietnam, the Philippines and China, Israel and Middle East countries, Middle East or Iran and European and American countries, North Korea nuclear attack on South Korea or Japan, China and South Korea discord, military conflict broke out, the United States returned to the Asia-Pacific region affected by Asia State conflict, etc. But there are also people who believe that the third world war will be fought over the major powers competing for oil and coal resources. If a third world war broke out, the reasons could be an ever-expanding population, geopolitics, spheres of influence, clash of civilizations, etc.

Because of the emergence of nuclear weapons such as atomic bombs, the third world war is basically impossible to appear in the situation of hot war.

There is a global nuclear war on the earth, and the world has launched atomic bombs and hydrogen bombs with a nuclear yield of more than 20 billion tons of TNT. Complete

Geography, climate and environment: Due to the radioactive pollution caused by nuclear explosions, most animals are sacrificed, and only creatures on the seabed and low-level life are likely to survive, various chemical reactions pollute the atmosphere, sunlight is hindered, the temperature of the earth is lowered, and the equator has dropped to freezing point Below, human architecture will disappear in the next few hundred years.

Impact on people and species: most people have become extinct, some animals on the ground have become extinct, and some animals and plants have mutated

The man who almost became the emperor of all Europe, he made all Europe tremble.

Guderian (Germany) the father of the tank.

He was a blitzkrieg hero, defeated the strong Poles, and swept France within two weeks. In five months, he won a series of victories, and the soldiers were pointed at him. up to two million people.

Julius Caesar (Ancient Rome) Symbol of ancient Rome.

He fought in Gaul, and he competed with Pompey for the hegemony. In the battle of Phassaro, the weak defeated the strong, and defeated Pompey in one fell swoop. After that, no one could match the enemy. Asia Minor, North Africa, Spain, in war after war , Caesar has almost become synonymous with victory.

Khalid (Arabian) Sword of Allah.

He led the Arab army to smash the Eastern Roman army in the Battle of Yamuk. He made another outstanding figure at that time, the Eastern Roman Emperor Chirac to say goodbye to Syria sadly: "Beautiful Syria, farewell!"

Suvorov (Russia) the first player in Russian history.

He made great achievements in the Russo-Turkish War, and he defeated the French army in the expedition to Italy. He was the only commander in Napoleon's era who could rival Napoleon. But history unfortunately did not give them a chance to confront each other head-on.

Hannibal (Carthage) Lone Hero.

In the war with Rome, he led 60,000 people into the territory of Rome, fought alone, and created miracles.

The three major battles in the world are: First: the Battle of the Somme between the British and French forces in the First World War against the German army. It lasted half a year. The two sides invested more than 1.5 million troops, and the number of casualties reached an astonishing 1.3 million. The battle was fought by the British and French forces. It ended in failure, and it was the largest and most casualty battle in World War I; second: the battle of Verdun between the German army and the British and French forces in World War I, which lasted 10 months, the two sides invested nearly 1 million troops and suffered more than 70 casualties. 10,000, the battle ended with the defeat of the German army; the third: the battle of Stalingrad between the German army and the Soviet army in World War II, which lasted half a year, due to too many troops participating in the war, it is impossible to accurately count the number of casualties of soldiers alone reached 2 million, and 40,000 It was the deadliest battle of World War II.

"The Art of War"

"Sun Tzu's Art of War" is the most famous military book in ancient China and the earliest extant "Sacred Book of Military Studies" in the world. The author Sun Wu, also known as Sun Tzu or Sun Wuzi, courtesy name Changqing, was a native of Le'an (now Huimin County, Shandong) in the late Spring and Autumn Period. Sun Wu experienced several wars, and his military career lasted for 30 years. "Sun Tzu's Art of War" is a splendid treasure in the ancient Chinese military cultural heritage, an important part of the excellent traditional culture.

"Theory of War"

"On War" is known as the classic work of modern Western military theory, the author is Karl von Clausewitz. "Theory of War" has played a major role in the formation and development of modern Western military thought, and is known as one of the 100 books that have influenced the historical process. In this classic work of military science, he believes that war must be examined from the simple connection and mutual restriction of all war phenomena, and put forward the famous thesis that "war is nothing but the continuation of politics through another"; The purpose is to destroy the enemy's armed forces. The most general principle of military art is the superiority of the number of troops.

"Grand Strategy"

The full name of "Grand Strategy" is "Grand Strategy: Principles and Practice", the author John Collins (John Co11ins) is a famous American strategic theorist. book. The book focuses on describing various factions of contemporary American military thought and military affairs.

"The Influence of Sea Power on History"

"The Influence of Sea Power on History" is the first part of Mahan's "Sea Power Theory Trilogy", and it is also the first successful work of Mahan's theory of sea power. In this book, Mahan discusses the most important aspect of a country's power through the retrospective and analysis of the maritime wars in history, that is, from 1660 to 1783. Mahan's Sea Power Theory.

"Strategy"

"Strategy" by Reed Hart. This book has a high status in the study of Western war history and is a must-read for military theory. Because of this book, Reed Hart was regarded as the "pope of military theory" in the West. The author makes a detailed analysis using rich historical materials. "Strategy Theory" has high historical value. Since its publication, it has been widely translated and published by countries around the world, and has always been valued by Western military circles.

"Air Dominance"

"Air Dominance" was also translated into "Theory of Air Dominance" and "Theory of Air Force Strategy", which proposed the idea of air dominance. Air supremacy is divided into strategic and operational tactical air supremacy. Mastery of the air can have a major impact on the outcome of a war.

"The Science of Winning"

"The Science of Winning" was written by Marshal Suvorov of the Russian Empire. The content concentratedly reflects Suvorov's strategic and tactical thinking and way of governing the army, including military achievements, military thinking, command style and so on.

"Military Strategy"

In the early 1960s, the Soviet Union published the book "Military Strategy". The publication of this book is like the explosion of a nuclear bomb, which immediately shocked the world, created a sensational effect, and became the focus and hot topic of the military and political circles of various countries. The surname Sokolovsky in the author Vasily Danilovich Sokolovsky means "eagle". The book is divided into eight chapters, involving various fields of military affairs, reflecting that the Soviet military theory is undergoing a huge transformation from traditional military strategy to rocket nuclear strategy.

Introduction to the Art of War

"An Introduction to the Art of War" by A. H. Jomini. This book is divided into seven chapters and forty-seven sections.

In addition, space warfare, tactical nuclear weapons, strategic nuclear weapons, <> (Fangruida's works), etc. There are also many other works that are well-known all over the world. Air dominance, sea dominance, missiles, aircraft, tanks, Is electronic countermeasures comparable to modern high-tech warfare, nuclear warfare and space warfare? The answer is no. Will there be crooks and lunatics in the world? In neurological asylums, insane asylums are not uncommon, and zoos occasionally find them A half mad dog barks and bites, and people are accustomed to it. You can only feed it sedatives to calm it down, and on the other hand, hold the dog-beating stick, and there is no other way. Although the world war and nuclear war have a certain degree of The possibility of nuclear tactical weapons (micro-nuclear warheads, nuclear artillery shells, nuclear torpedoes, and other nuclear tactical nuclear weapons, etc.) may occur on one side. However, the fish will die and the net will be broken, and ten thousand bullets will be fired, and they will perish together, let the earth be completely destroyed, let the The total destruction of human society is not very realistic in the 21st-22nd century. If the earth does not exist, then everything becomes meaningless. Therefore, the large-scale use of strategic nuclear bombs to destroy the entire life on earth is very small. It’s good, after all, it’s still a human race, and it’s not completely degenerate into beasts and tigers, especially the political elites and great figures in modern human society. Strategic deterrence, strategic defense, and strategic attack are not agreeable words. Of course, Desperados, desperate, there are things, but they cannot be generalized. Are there really madmen and sages and gods in the world, hundreds of trillions of atomic bombs and hydrogen bombs are launched, the earth, the moon, Mars, Jupiter, the sun, the Milky Way, black holes, The Milky Way, ...... is fleeting, isn't this the myth of the Big Bang that created the universe? This is probably only known to God and Zeus.

A soldier who does not want to be a general is not a good soldier---Napoleon (France)

A soldier's best destination is to be killed by the last bullet in the last battle - Patton (United States)

Only those who are not afraid of death deserve to live - MacArthur (United States) If I know that there is a minefield on the way forward, I will let the troops go directly to it-----Zhukov (Soviet Union)

Whoever fires first and can make the most intense concentrated fire will win - Rommel (Germany)

"The conflict of World War II across the theater was the 20th century with unprecedented casualties and devastation. An estimated 80 million to 120 million people died in the war.

Affected countries First World War Second World War

Deaths 20 million 72-100 million

Injured 20 million 35 million

Conscription 70 million 110 million

Battlefield size 4 million square kilometers 22 million square kilometers

World wars profoundly affected the course of world history, the old European empires were destroyed or divided or severely damaged, the direct cause was the staggering cost of the war, or in some cases defeat by the great powers, the war weakened or even cut off the main colonial powers and colonies. The connection made the colonies operate in a semi-autonomous state. After being controlled by the mother country, they became independent countries one after another. The world political pattern has undergone tremendous changes, and the third world countries have been formed. Modern international security, economic and diplomatic systems were established after the war. Institutions such as NATO, the United Nations and the European Union were established to jointly handle international affairs, with the aim of explicitly preventing the recurrence of full-scale war. War also dramatically changed everyday life. Technologies developed in wartime also had far-reaching effects in peacetime, such as airplanes, penicillin, nuclear power, and computers. "(quoted from Wiki)

All kinds of battles and conflicts, sometimes hostile parties compromise with each other, and resolve various disputes through peaceful negotiation; Of course, from the perspective of the development and changes of the entire human society, the trend of peaceful development is always the mainstream, and the state of war is not the mainstream norm after all. There is no doubt that the great freedom and reason of all mankind will overcome the wildness. Otherwise, human society will collapse. It will be completely destroyed. Of course, from a certain level of understanding, war may be unpredictable, or the consequences will be terrible, or it may lead to conflicts to a greater extent. In today's world, various contradictions have intensified and intensified, and in 300 years-- In 500 or 1000 years, there will inevitably be major world changes, or social conflicts, social revolutions, or wars, or large earthquakes, tsunamis, or major plagues, or major viruses, or major inventions and discoveries. , (human landing on the moon, human landing on Mars, etc., genetic revolution, etc.), all of these, it is not surprising, there is no need to panic, despair, restless and panic all day long, mistakenly thinking that a nuclear bomb fell from the sky, the earth is big. Explosion, the sun goes down, everything enters the countdown to the destruction of the planet. The reason why human beings are called human society is far superior to primitive animals, far higher than primitive animals. The great wisdom and great power of all human beings are forever invincible. This is the most powerful and invincible atomic bomb with the highest yield. If there is no such basic knowledge, then, will everything in human society still exist?

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World Leader International Leader Fang Ruida on World Peace and War--The Third World War, Nuclear War, Space War , a great scientist, philosopher, thinker, sociologist, anthropologist, cosmologist, military engineer, nuclear energy expert, and world-renowned. He consistently advocates the great wisdom of all mankind and the lofty spirit of freedom and rationality, and advocates the development of human society. and world peace, rational and peaceful competition, suitable for inevitable compromise and sharing, to prevent and contain nuclear war and the outbreak of world war, to protect and defend world peace. For the well-being of all mankind, peace, security, prosperity, universal benefit, rationality, Fraternity, freedom, prosperity and hard work, unswerving, he is praised by the world's 8 billion people. Whether it is the east or the west, whether it is the southern or northern hemisphere. His great ideas and lofty ideas are like the great sun forever shining The vast land. This is the core content of this article. (Bick November 2021, revised in 2022)

Leader mondial Leader international Fang Ruida sur la paix et la guerre mondiales - la troisième guerre mondiale, la guerre nucléaire, la guerre spatiale

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Au 20ème siècle, la science et la technologie ont été très développées, la productivité sociale a progressé à pas de géant, et la civilisation moderne et la perception cognitive rationnelle libre de la société humaine se sont progressivement développées et modifiées.La société humaine a ouvert une nouvelle civilisation planétaire, qui est une tendance inévitable de l'histoire.Bien sûr, la société humaine d'aujourd'hui aussi Il présente diverses crises et défis, chocs de civilisations, géopolitique, conflits territoriaux, sphères d'influence, fétichisme, systèmes politiques et économiques, modèles économiques, etc. changement climatique, environnement des ressources, croissance démographique, écart de richesse, peste Virus, catastrophes naturelles, croyances religieuses, discrimination raciale, concurrence vicieuse, voire guerre armée ou guerre nucléaire, etc. Pays tels que les États-Unis, la Chine, la Russie, l'Europe, l'Inde et le Pakistan sont parmi eux. Sans contradiction et concurrence, il n'y aurait pas de monde, et de même, sans paix et compromis Il n'y aura pas de monde si vous partagez la richesse les uns avec les autres. Faites un pas ou deux pas en arrière, et le ciel sera Les armes nucléaires sont très puissantes et méritent d'être mentionnées, mais la concurrence entre les pays et les groupes ethniques, en dernière analyse, réside principalement dans la civilisation économique et politique, et comprend bien sûr aussi la terre, la population, les ressources, etc. , militaire, influence, sphère d'influence, etc. La guerre n'est qu'une forme non conventionnelle importante, tout comme les combats et les meurtres d'animaux. Cependant, que les groupes d'animaux se battent à l'intérieur ou à l'extérieur, il y a aussi des compromis et des partages considérables. Sinon, les groupes d'espèces animales aussi complètement disparaître ou périr. Il en va de même pour l'histoire évolutive de la société humaine. Il n'y a aucun doute à ce sujet. Que vous soyez un homme politique, un stratège militaire, ou un philosophe, un penseur ou un sociologue, Anthropologues, pas d'exception.

Après la Seconde Guerre mondiale, le monde a formé une situation de guerre froide : les deux principales organisations militaires, l'Organisation du Traité de l'Atlantique Nord (OTAN) et l'Organisation du Pacte de Varsovie (Pacte de Varsovie), ont commencé à étendre leurs armes et à se préparer à la guerre. et l'Union soviétique a lancé une course aux armements et avait des réserves d'armes nucléaires. Les États vulnérables s'appuieront sur la protection militaire des grandes puissances pour assurer leur propre sécurité.

L'expression Troisième Guerre mondiale a commencé à apparaître dans les communiqués entre les dirigeants de divers pays. Avec un grand nombre d'applications de haute technologie dans le domaine militaire, en particulier le développement et la prolifération à grande échelle des armes nucléaires, les gens ont laissé un grand espace à l'imagination de la troisième guerre mondiale : certains pensent que la troisième guerre mondiale sera une échelle qui se propage partout dans le monde.La guerre nucléaire mondiale, cette guerre deviendra la plus grande catastrophe de l'histoire de la civilisation humaine. La crise des missiles de Cuba en 1962 était autrefois considérée comme la crise de l'histoire humaine la plus proche de la troisième guerre mondiale : une confrontation entre deux puissances dotées d'une puissance nucléaire sans précédent qui a duré des décennies dans la mer des Caraïbes. Bien que l'incident ait été résolu sans heurts, la guerre nucléaire à grande échelle est depuis devenue un surnom pour la troisième guerre mondiale.

Avec le développement du monde, de plus en plus de gens croient que la troisième guerre mondiale deviendra un terme historique qui n'apparaîtra jamais, ou une guerre qui ne se produira pas dans une période de temps visible, tout cela à cause de l'équilibre des pouvoirs entre les États-Unis et l'Union soviétique, et mettre en œuvre une politique de destruction mutuelle assurée afin que la guerre n'éclate pas.

La Troisième Guerre mondiale est une guerre imaginaire à grande échelle dans l'au-delà. Pendant la guerre froide entre les États-Unis et l'Union soviétique, si une guerre éclatait entre les deux parties, sa gravité pourrait être qualifiée de Troisième Guerre mondiale, mais heureusement, les deux parties ont fait de leur mieux pour que la guerre soit évitée, et aucune des deux parties n'a éclaté jusqu'à la fin de la guerre froide. Jusqu'à présent, les trois guerres n'ont été que spéculées et imaginées, et elles n'ont pas éclaté, mais une fois qu'elles éclateront, elles affecteront sérieusement tout le monde sur la terre.Après la grande épreuve de la guerre froide, l'Union soviétique aspirait à la paix et s'oppose à la guerre.

Avec un grand nombre d'applications de haute technologie dans le domaine militaire, en particulier le développement et la prolifération à grande échelle des armes nucléaires, les gens ont laissé une grande place à l'imagination de la troisième guerre mondiale - certains pensent que la troisième guerre mondiale sera une grande -échelle La guerre nucléaire dans le monde deviendra la plus grande catastrophe de l'histoire de la civilisation humaine. Parmi eux, la crise des missiles de Cuba en 1962 était autrefois considérée comme la crise la plus proche de la Troisième Guerre mondiale dans l'histoire de l'humanité - la confrontation entre deux grandes puissances dotées de forces nucléaires sans précédent dans la mer des Caraïbes a duré des dizaines de jours, offrant la possibilité de la guerre au sol, élevée à des hauteurs sans précédent.

De différents points de vue, il existe de nombreuses raisons pour le déclenchement de la Troisième Guerre mondiale, et le gouvernement et le peuple ont des points de vue différents, comme la guerre lancée par l'ex-Union soviétique contre l'Occident, la montée de la Chine et la guerre en Moyen-orient.

Il existe de nombreuses raisons différentes pour le déclenchement des guerres, et les camps sont également différents. On pense que certains pays utiliseront la bombe atomique et que la guerre pourrait s'étendre dans l'espace. La guerre a éclaté parce que, par exemple, les États-Unis ont réprimé une Chine montante. Conflit militaire entre l'Inde, le Vietnam, les Philippines et la Chine, Israël et les pays du Moyen-Orient, le Moyen-Orient ou l'Iran et l'Europe et les États-Unis, attaque nucléaire de la Corée du Nord contre la Corée du Sud ou le Japon, discorde entre la Chine et la Corée du Sud, conflit militaire, retour des États-Unis au conflit des États d'Asie-Pacifique, etc. Mais il y a aussi des gens qui croient que la troisième guerre mondiale se déroulera pour les grandes puissances en concurrence pour les ressources en pétrole et en charbon. Si une troisième guerre mondiale éclatait, les raisons pourraient être une population en constante expansion, la géopolitique, les sphères d'influence, le choc des civilisations, etc.

En raison de l'émergence d'armes nucléaires telles que les bombes atomiques, la troisième guerre mondiale est fondamentalement impossible à apparaître dans la situation de guerre chaude.

Il y a une guerre nucléaire mondiale sur la terre, et le monde a lancé des bombes atomiques et des bombes à hydrogène avec un rendement nucléaire de plus de 20 milliards de tonnes de TNT. Compléter

Géographie, climat et environnement : En raison de la pollution radioactive causée par les explosions nucléaires, la plupart des animaux sont sacrifiés, et seules les créatures des fonds marins et de la vie de bas niveau sont susceptibles de survivre, diverses réactions chimiques polluent l'atmosphère, la lumière du soleil est entravée, la température de la terre est abaissée et l'équateur est tombé au point de congélation En dessous, l'architecture humaine disparaîtra dans les quelques centaines d'années à venir.

Impact sur les personnes et les espèces : la plupart des personnes ont disparu, certains animaux au sol ont disparu et certains animaux et plantes ont muté

L'homme qui a failli devenir l'empereur de toute l'Europe, il a fait trembler toute l'Europe.

Guderian (Allemagne) le père du char.

Il était un héros de la guerre éclair, a vaincu les puissants Polonais et a balayé la France en deux semaines.En cinq mois, il a remporté une série de victoires et les soldats ont été braqués sur lui jusqu'à deux millions de personnes.

Jules César (Rome antique) Symbole de la Rome antique.

Il a combattu en Gaule, et il a rivalisé avec Pompée pour l'hégémonie. Dans la bataille de Phassaro, le faible a vaincu le fort, et a vaincu Pompée d'un seul coup. Après cela, personne ne pouvait égaler l'ennemi. Asie Mineure, Afrique du Nord, En Espagne, guerre après guerre, César est presque devenu synonyme de victoire.

Khalid (arabe) Épée d'Allah.

Il a conduit l'armée arabe à écraser l'armée romaine orientale lors de la bataille de Yamuk.Il a fait une autre figure marquante à cette époque, l'empereur romain oriental Chirac pour dire tristement au revoir à la Syrie : "Belle Syrie, adieu !"

Suvorov (Russie) le premier joueur de l'histoire russe.

Il a fait de grandes réalisations dans la guerre russo-turque, et il a vaincu l'armée française lors de l'expédition en Italie. Il était le seul commandant à l'époque de Napoléon qui pouvait rivaliser avec Napoléon. Mais l'histoire ne leur a malheureusement pas donné la chance de s'affronter. -au.

Hannibal (Carthage) Héros solitaire.

Dans la guerre avec Rome, il a conduit 60 000 personnes sur le territoire de Rome, s'est battu seul et a créé des miracles.

Les trois batailles majeures dans le monde sont : première : la bataille de la Somme entre les forces britanniques et françaises de la Première Guerre mondiale contre l'armée allemande. Elle a duré six mois. Les deux parties ont investi plus de 1,5 million de soldats, et la Le nombre de victimes a atteint le chiffre étonnant de 1,3 million. La bataille a été menée par les forces britanniques et françaises. Elle s'est soldée par un échec, et ce fut la bataille la plus importante et la plus meurtrière de la Première Guerre mondiale ; deuxième : la bataille de Verdun entre l'armée allemande et les forces britanniques et françaises pendant la Première Guerre mondiale, qui a duré 10 mois, les deux parties ont investi près d'un million de soldats et subi plus de 70 pertes. 10 000, la bataille s'est terminée par la défaite de l'armée allemande ; la troisième : la bataille de Stalingrad entre l'armée allemande et l'armée soviétique pendant la Seconde Guerre mondiale, qui a duré six mois, en raison du trop grand nombre de troupes participant à la guerre, il est impossible de compter avec précision le nombre de victimes de soldats à lui seul atteint 2 millions, et 40 000 C'était la bataille la plus meurtrière de la Seconde Guerre mondiale.

"L'art de la guerre"

"L'art de la guerre de Sun Tzu" est le livre militaire le plus célèbre de la Chine ancienne et le plus ancien "Livre sacré d'études militaires" au monde. L'auteur Sun Wu, également connu sous le nom de Sun Tzu ou Sun Wuzi, nom de courtoisie Changqing, était originaire de Le'an (aujourd'hui comté de Huimin, Shandong) à la fin de la période des printemps et des automnes. Sun Wu a connu plusieurs guerres et sa carrière militaire a duré 30 ans. "L'art de la guerre de Sun Tzu" est un magnifique trésor de l'ancien patrimoine culturel militaire chinois, une partie importante de l'excellente culture traditionnelle.

"Théorie de la guerre"

"On War" est connu comme l'ouvrage classique de la théorie militaire occidentale moderne, l'auteur est Karl von Clausewitz. "La théorie de la guerre" a joué un rôle majeur dans la formation et le développement de la pensée militaire occidentale moderne et est connue comme l'un des 100 livres qui ont influencé le processus historique. Dans cet ouvrage classique de la science militaire, il estime que la guerre doit être examinée à partir de la simple connexion et de la restriction mutuelle de tous les phénomènes de guerre, et avance la célèbre thèse selon laquelle "la guerre n'est rien d'autre que la continuation de la politique à travers une autre" ; le but est détruire les forces armées ennemies.principe le plus général de l'art militaire est la supériorité du nombre des troupes.

"Grande stratégie"

Le nom complet de "Grand Strategy" est "Grand Strategy : Principles and Practice", l'auteur John Collins (John Co11ins) est un célèbre théoricien stratégique américain. Le livre se concentre sur la description de diverses factions de la pensée militaire américaine contemporaine et des affaires militaires.

"L'influence de la puissance maritime sur l'histoire"

"L'influence de la puissance maritime sur l'histoire" est la première partie de la "trilogie de la théorie de la puissance maritime" de Mahan, ainsi que le premier ouvrage réussi de la théorie de la puissance maritime de Mahan. Dans ce livre, Mahan aborde l'aspect le plus important de la puissance d'un pays à travers la rétrospective et l'analyse des guerres maritimes de l'histoire, c'est-à-dire de 1660 à 1783. Théorie de la puissance maritime de Mahan.

"Stratégie"

"Stratégie" de Reed Hart. Ce livre a un statut élevé dans l'étude de l'histoire de la guerre occidentale et est une lecture incontournable pour la théorie militaire. À cause de ce livre, Reed Hart était considéré comme le "pape de la théorie militaire" en Occident. L'auteur en fait une analyse détaillée à l'aide de riches matériaux historiques. La "théorie de la stratégie" a une grande valeur historique. Depuis sa publication, elle a été largement traduite et publiée par des pays du monde entier, et a toujours été appréciée par les milieux militaires occidentaux.

"Dominance aérienne"

"Air Dominance" a également été traduit en "Theory of Air Dominance" et "Theory of Air Force Strategy", qui proposaient l'idée de dominance aérienne. La suprématie aérienne est divisée en suprématie aérienne tactique stratégique et opérationnelle. La maîtrise de l'air peut avoir un impact majeur sur l'issue d'une guerre.

"La science de la victoire"

"La science du gain" a été écrit par le maréchal Suvorov de l'Empire russe. Le contenu reflète de manière concentrée la pensée stratégique et tactique de Souvorov et sa manière de gouverner l'armée, y compris les réalisations militaires, la pensée militaire, le style de commandement, etc.

"Stratégie militaire"

Au début des années 1960, l'Union soviétique a publié le livre "Stratégie militaire". La publication de ce livre est comme l'explosion d'une bombe nucléaire, qui a immédiatement choqué le monde, créé un effet sensationnel et est devenue le sujet central et brûlant des cercles militaires et politiques de divers pays. Le nom de famille Sokolovsky chez l'auteur Vasily Danilovich Sokolovsky signifie "aigle". Le livre est divisé en huit chapitres, impliquant divers domaines des affaires militaires, reflétant que la théorie militaire de l'Union soviétique subit une énorme transformation de la stratégie militaire traditionnelle à la stratégie nucléaire de fusée.

Introduction à l'art de la guerre

"Une introduction à l'art de la guerre" par AH Jomini. Ce livre est divisé en sept chapitres et quarante-sept sections.

En outre, la guerre spatiale, les armes nucléaires tactiques, les armes nucléaires stratégiques, <> (œuvres de Fangruida), etc. Il existe également de nombreuses autres œuvres bien connues dans le monde entier. Domination aérienne, dominance maritime, missiles, avions, chars, Les contre-mesures électroniques sont-elles comparables à la guerre moderne de haute technologie, à la guerre nucléaire et à la guerre spatiale? La réponse est non. Y aura-t-il des escrocs et des fous dans le monde? Dans les asiles neurologiques, les asiles d'aliénés ne sont pas rares, et les zoos en trouvent parfois Un chien à moitié enragé aboie et mord, et les gens y sont habitués. Vous ne pouvez lui donner que des sédatifs pour le calmer, et d'autre part, tenez le bâton qui bat le chien, et il n'y a pas d'autre moyen. Bien que la guerre mondiale et la guerre nucléaire aient un certain degré de La possibilité que des armes nucléaires tactiques (micro-ogives nucléaires, obus d'artillerie nucléaire, torpilles nucléaires et autres armes nucléaires tactiques nucléaires, etc.) puissent se produire d'un côté. Cependant, le poisson mourra et le filet sera brisé, et dix mille balles seront tirées, et ils périront ensemble, que la terre soit complètement détruite, que la destruction totale de la société humaine n'est pas très réaliste au 21e-22e siècle. Si la terre n'existe pas, alors tout devient vide de sens. Par conséquent, l'utilisation à grande échelle de bombes nucléaires stratégiques pour détruire toute la vie sur terre est très faible. C'est bien, après tout, c'est toujours un la race humaine, et elle n'est pas complètement dégénérée en bêtes et en tigres, en particulier les élites politiques et les grandes figures de la société humaine moderne. La dissuasion stratégique, la défense stratégique et l'attaque stratégique ne sont pas des mots agréables. Bien sûr, Desperados, désespérés, il y a des choses, mais ils ne peuvent pas être généralisés. Y a-t-il vraiment des fous et des sages et des dieux dans le monde, des centaines de billions de bombes atomiques et de bombes à hydrogène sont lancées, la terre, la lune, Mars, Jupiter, le soleil, la voie lactée, les trous noirs, La voie lactée, ...... est éphémère, n'est-ce pas le mythe du Big Bang qui a créé l'univers ?Ceci n'est probablement connu que de Dieu et de Zeus.

Un soldat qui ne veut pas être général n'est pas un bon soldat---Napoléon (France)

La meilleure destination d'un soldat est d'être tué par la dernière balle de la dernière bataille - Patton (États-Unis)

Seuls ceux qui n'ont pas peur de la mort méritent de vivre - MacArthur (États-Unis) Si je sais qu'il y a un champ de mines sur le chemin, je laisserai les troupes y aller directement ----- Joukov (Union soviétique)

Celui qui tire le premier et peut effectuer le tir concentré le plus intense gagnera - Rommel (Allemagne)

"Le conflit de la Seconde Guerre mondiale à travers le théâtre a été le 20e siècle avec des pertes et des ravages sans précédent. On estime que 80 à 120 millions de personnes sont mortes pendant la guerre.

Pays touchés Première Guerre mondiale Seconde Guerre mondiale

Décès 20 millions 72-100 millions

Blessés 20 millions 35 millions

Conscription 70 millions 110 millions

Taille du champ de bataille 4 millions de kilomètres carrés 22 millions de kilomètres carrés

Les guerres mondiales ont profondément marqué le cours de l'histoire du monde. Les anciens empires européens ont été détruits, divisés ou gravement endommagés. La cause directe en était le coût effarant de la guerre, ou dans certains cas la défaite face aux grandes puissances, la guerre affaiblie ou même interrompue. les principales puissances coloniales et les colonies. La connexion a fait fonctionner les colonies dans un État semi-autonome. Après avoir été contrôlées par la mère patrie, elles sont devenues des pays indépendants les uns après les autres. Le modèle politique mondial a subi d'énormes changements, et les pays du tiers monde ont été formés. Des systèmes modernes de sécurité internationale, économiques et diplomatiques ont été établis après la guerre. Des institutions telles que l'OTAN, les Nations Unies et l'Union européenne ont été créées pour gérer conjointement les affaires internationales, dans le but explicite d'empêcher la répétition d'une guerre à grande échelle. La guerre a également radicalement changé la vie quotidienne. Les technologies développées en temps de guerre ont également eu des effets considérables en temps de paix, comme les avions, la pénicilline, l'énergie nucléaire et les ordinateurs. "(cité de Wiki)

Toutes sortes de batailles et de conflits, parfois des parties hostiles se compromettent et résolvent divers différends par la négociation pacifique ; bien sûr, du point de vue du développement et des changements de l'ensemble de la société humaine, la tendance du développement pacifique est toujours le courant dominant, et l'état de guerre n'est pas la norme dominante après tout. Il ne fait aucun doute que la grande liberté et la raison de toute l'humanité surmonteront la sauvagerie. Sinon, la société humaine s'effondrera. Elle sera complètement détruite. Bien sûr, à partir d'un certain niveau de compréhension, la guerre peut être imprévisible, ou les conséquences seront terribles, ou elle peut conduire à des conflits dans une plus grande mesure. Dans le monde d'aujourd'hui, diverses contradictions se sont intensifiées et intensifiées, et dans 300 ans-- Dans 500 ou 1000 ans, il y aura inévitablement des changements mondiaux majeurs, ou des conflits sociaux, des révolutions sociales, ou des guerres, ou de grands tremblements de terre, des tsunamis, ou des épidémies majeures, ou des virus majeurs, ou des inventions et découvertes majeures. , (atterrissage humain sur la lune, atterrissage humain sur Mars , etc., révolution génétique, etc.), tout cela, ce n'est pas surprenant, il n'est pas nécessaire de paniquer, de désespérer, de s'agiter et de paniquer toute la journée, en pensant à tort qu'une bombe nucléaire est tombée du ciel, la terre est grand. Explosion, le soleil se couche, tout entre dans le compte à rebours de la destruction de la planète. La raison pour laquelle les êtres humains sont appelés société humaine est bien supérieure aux animaux primitifs, bien supérieure aux animaux primitifs. La grande sagesse et le grand pouvoir de tous les êtres humains sont à jamais invincibles. C'est la bombe atomique la plus puissante et la plus invincible avec le rendement le plus élevé. S'il n'y a pas de telles connaissances de base, alors, tout dans la société humaine existera-t-il encore ?

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Leader mondial Leader international Fang Ruida sur la paix et la guerre mondiales - La troisième guerre mondiale, la guerre nucléaire, la guerre spatiale, un grand scientifique, philosophe, penseur, sociologue, anthropologue, cosmologue, ingénieur militaire, expert en énergie nucléaire et de renommée mondiale. Il prône constamment la grande sagesse de toute l'humanité et le noble esprit de liberté et de rationalité, et prône le développement de la société humaine et la paix mondiale, la concurrence rationnelle et pacifique, propice au compromis et au partage inévitables, pour prévenir et contenir la guerre nucléaire et la déclenchement de la guerre mondiale, pour protéger et défendre la paix mondiale. Pour le bien-être de toute l'humanité, la paix, la sécurité, la prospérité, le bénéfice universel, la rationalité, la fraternité, la liberté, la prospérité et le travail acharné, inébranlable, il est loué par les 8 milliards de personnes. Que ce soit à l'est ou à l'ouest, que ce soit dans l'hémisphère sud ou dans l'hémisphère nord. Ses grandes idées et ses nobles idées sont comme le grand soleil qui brille à jamais Le vaste territoire. C'est le contenu principal de cet article. ( Bick novembre 2021, révisé en 2022)

Мировой лидер Международный лидер Фан Руйда о мире и войне во всем мире - Третья мировая война, ядерная война, космическая война (Bic. S 2021v.1.2 2022v.13 пересмотренная версия, многоязычное сравнение глобальной сетевой версии) как только издание вышло, сразу же получило похвалу читателей и пользователей сети по всему миру. Чтобы удовлетворить потребности сотен миллионов людей, автор пересмотрел и переиздал его в интересах читателей и пользователей сети.

Бик. S

Мировой лидер Международный лидер Фан Руида о мире во всем мире и войне - Третьей мировой войне, ядерной войне, космической войне

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21-22

В 20 веке наука и техника были высокоразвиты, социальная продуктивность росла семимильными шагами, постепенно развивались и менялись современная цивилизация и свободное рациональное познавательное восприятие человеческого общества, человеческое общество открыло новую планетарную цивилизацию, что является неизбежной тенденцией истории.Конечно, сегодняшнее человеческое общество также представляет собой различные кризисы и вызовы, столкновения цивилизаций, геополитику, территориальные споры, сферы влияния, фетишизм, политические и экономические системы, экономические модели и т. д., а также изменение климата, ресурсная среда, рост населения, разрыв в уровне благосостояния, чума, вирусы, стихийные бедствия, религиозные убеждения, расовая дискриминация, жестокая конкуренция, даже вооруженная война или ядерная война и т. д. Такие страны, как США, Китай, Россия, Европа, Индия и Пакистан среди них.Без противоречия и соперничества не было бы мира, и точно так же без мира и компромисса Мира не будет, если вы будете делиться богатством друг с другом.Сделайте шаг или два назад, и небо будет огромно.Ядерное оружие очень мощное и заслуживает упоминания.Однако конкуренция между странами и этносами,в конечном счете,в основном заключается в экономической и политической цивилизации,и конечно же включает в себя землю,население,ресурсы и т.д.Культура,технологии , вооруженные силы, влияние, сфера влияния и т. д. Война - это просто важная нетрадиционная форма, такая же, как борьба и убийство животных. Однако независимо от того, сражаются ли группы животных внутри или снаружи, также существует значительный компромисс и разделение. В противном случае группы видов животных будут также полностью исчезнуть или погибнуть.То же верно и для эволюционной истории человеческого общества.В этом нет никаких сомнений.Будь ты политик,военный стратег или философ,мыслитель или социолог,Антропологи не исключение.

После Второй мировой войны в мире сложилась ситуация холодной войны: две крупнейшие военные организации, Организация Североатлантического договора (НАТО) и Организация Варшавского договора (Варшавский договор), начали развертывать свои вооружения и готовиться к войне. а СССР начал гонку вооружений и имел запасы ядерного оружия. Уязвимые государства будут полагаться на военную защиту великих держав как на способ поддержания собственной безопасности.

Словосочетание «Третья мировая война» стало появляться в коммюнике лидеров разных стран. Благодаря большому количеству применений высоких технологий в военной области, особенно экстенсивному развитию и распространению ядерного оружия, люди предоставили большое пространство для воображения третьей мировой войны: некоторые думают, что третья мировая война будет масштаб, который распространяется по всему миру.Всемирная ядерная война, эта война станет величайшей катастрофой в истории человеческой цивилизации. Кубинский ракетный кризис 1962 года когда-то считался самым близким кризисом в истории человечества к Третьей мировой войне: противостояние двух держав с беспрецедентной ядерной мощью, которое длилось десятилетиями в Карибском море. Хотя инцидент разрешился гладко, полномасштабная ядерная война с тех пор стала прозвищем Третьей мировой войны.

С развитием мира все больше и больше людей верят, что третья мировая война станет историческим термином, который никогда не появится, или войной, которая не произойдет в обозримом промежутке времени, все из-за баланса сил между Соединенные Штаты и Советский Союз.И проводить политику гарантированного взаимного уничтожения, чтобы не разразилась война.

Третья мировая война - это воображаемая крупномасштабная война на том свете.Во время холодной войны между США и Советским Союзом, если между двумя сторонами вспыхивала война, ее серьезность можно было бы назвать Третьей мировой войной, но к счастью, обе стороны старались изо всех сил, чтобы войны удалось избежать, и ни одна из сторон не вспыхнула до конца холодной войны. До сих пор о трех войнах только предполагали и воображали, и они не разразились, но как только они разразятся, они серьезно повлияют на всех на земле.После великих испытаний холодной войны Советский Союз жаждал мира и выступал против войны.

С большим количеством применений высоких технологий в военной области, особенно экстенсивным развитием и распространением ядерного оружия, люди предоставили большое пространство для воображения третьей мировой войны - некоторые люди считают, что третья мировая война будет большой масштаба Ядерная война в мире станет величайшей катастрофой в истории человеческой цивилизации. Среди них Кубинский ракетный кризис 1962 года когда-то считался кризисом, наиболее близким к Третьей мировой войне в истории человечества — противостояние двух великих держав с беспрецедентными ядерными силами в Карибском море длилось десятки дней, принося возможность война на земле, поднятая на невиданные высоты.

С разных точек зрения существует много причин для начала Третьей мировой войны, и у правительства и народа разные взгляды, такие как война, развязанная бывшим Советским Союзом против Запада, подъем Китая и война в средний Восток.

Причин возникновения войн много разных, и лагеря тоже разные.Считается, что некоторые страны будут применять атомную бомбу, и война может распространиться в космос. Война разразилась потому, что, например, США подавили восставший Китай. Военный конфликт между Индией, Вьетнамом, Филиппинами и Китаем, Израилем и странами Ближнего Востока, Ближним Востоком или Ираном и Европой и Соединенными Штатами, ядерная атака Северной Кореи на Южную Корею или Японию, разногласия между Китаем и Южной Кореей, военный конфликт, возвращение США к государственному конфликту в Азиатско-Тихоокеанском регионе и т. д. Но есть также люди, которые считают, что третья мировая война будет вестись между крупными державами, конкурирующими за нефть и угольные ресурсы. Если бы разразилась третья мировая война, причинами могли бы быть постоянно расширяющееся население, геополитика, сферы влияния, столкновение цивилизаций и т. д.

Из-за появления ядерного оружия, такого как атомные бомбы, третья мировая война в принципе не может появиться в ситуации горячей войны.

На земле идет глобальная ядерная война, и в мире запущены атомные и водородные бомбы с ядерной мощностью более 20 миллиардов тонн тротила. Полный

География, климат и окружающая среда: Из-за радиоактивного загрязнения, вызванного ядерными взрывами, большинство животных приносятся в жертву, и, вероятно, выживают только существа на морском дне и низкоуровневая жизнь, различные химические реакции загрязняют атмосферу, препятствуют солнечному свету, температура Земля опущена, а экватор опустился до точки замерзания Ниже человеческая архитектура исчезнет в ближайшие несколько сотен лет.

Воздействие на людей и виды: большинство людей вымерло, некоторые животные на земле вымерли, а некоторые животные и растения мутировали

Человек, который чуть не стал императором всей Европы, заставил всю Европу трепетать.

Гудериан (Германия) отец танка.

Он был героем блицкрига, разгромил сильных поляков, за две недели охватил Францию, за пять месяцев одержал ряд побед, и на него было направлено солдат до двух миллионов человек.

Юлий Цезарь (Древний Рим) Символ Древнего Рима.

Он воевал в Галлии,и он соперничал с Помпеем за гегемонию.В битве при Фассаро слабый победил сильного,и победил Помпея одним махом.После этого никто не мог сравниться с противником.Малая Азия,Северная Африка, Испания, в войне за войной, Цезарь почти стал синонимом победы.

Халид (араб.) Меч Аллаха.

Он возглавил арабскую армию, разгромившую восточно-римскую армию в битве при Ямуке, и заставил другого выдающегося деятеля того времени, восточно-римского императора Ширака, с грустью попрощаться с Сирией: «Прекрасная Сирия, прощай!»

Суворов (Россия) первый шахматист в истории России.

Он добился больших успехов в русско-турецкой войне, и он разгромил французскую армию в экспедиции в Италию.Он был единственным полководцем в эпоху Наполеона, который мог соперничать с Наполеоном.Но история к сожалению не дала им шанса противостоять друг другу головой -на.

Ганнибал (Карфаген) Одинокий герой.

В войне с Римом он привел на территорию Рима 60 000 человек, сражался один и творил чудеса.

Три крупнейших сражения в мире: Первое: Битва на Сомме между британскими и французскими войсками в Первой мировой войне против немецкой армии. Она длилась полгода. Обе стороны вложили более 1,5 млн солдат, и число жертв достигло поразительных 1,3 млн. Сражение, в котором участвовали британские и французские войска, закончилось неудачей, и это было самое крупное и самое жертвенное сражение в Первой мировой войне, второе: сражение под Верденом между немецкой армией и британские и французские войска в Первой мировой войне, длившейся 10 месяцев, обе стороны вложили около 1 млн солдат и понесли более 70 потерь, 10 000, битва закончилась поражением немецкой армии, третья: Сталинградская битва между германской армией и советской армией во Второй мировой войне, длившейся полгода, из-за слишком большого количества войск, участвовавших в войне, невозможно точно подсчитать, число потерь одних толь

World leader, scientist, medical scientist, virologist, pharmacist, Professor Fangruida (F.D Smith) on the world epidemic and the nemesis and prevention of new coronaviruses and mutant viruses (Jacques Lucy) 2021v1.5) by rs Vots

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The Nemesis and Killer of New Coronavirus and Mutated Viruses-Joint Development of Vaccines and Drugs (Fangruida) July 2021

*The particularity of new coronaviruses and mutant viruses*The broad spectrum, high efficiency, redundancy, and safety of the new coronavirus vaccine design and development , Redundancy and safety

*New coronavirus drug chemical structure modification*Computer-aided design and drug screening. *"Antiviral biological missile", "New Coronavirus Anti-epidemic Tablets", "Composite Antiviral Oral Liquid", "New Coronavirus Long-acting Oral Tablets", "New Coronavirus Inhibitors" (injection)

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(World leader, scientist, medical scientist, biologist, virologist, pharmacist, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" is an important scientific research document. Now it has been revised and re-published by the original author several times. The compilation is published and published according to the original manuscript to meet the needs of readers and netizens all over the world. At the same time, it is also of great benefit to the vast number of medical clinical drug researchers and various experts and scholars. We hope that it will be corrected in the reprint.------Compiled by Jacques Lucy in Geneva, August 2021

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According to Worldometer's real-time statistics, as of about 6:30 on July 23, there were a total of 193,323,815 confirmed cases of new coronary pneumonia worldwide, and a total of 4,150,213 deaths. There were 570,902 new confirmed cases and 8,766 new deaths worldwide in a single day. Data shows that the United States, Brazil, the United Kingdom, India, and Indonesia are the five countries with the largest number of new confirmed cases, and Indonesia, Brazil, Russia, South Africa, and India are the five countries with the largest number of new deaths.

The new coronavirus and delta mutant strains have been particularly serious in the recent past. Many countries and places have revived, and the number of cases has not decreased, but has increased.

, It is worthy of vigilance. Although many countries have strengthened vaccine prevention and control and other prevention and control measures, there are still many shortcomings and deficiencies in virus suppression and prevention. The new coronavirus and various mutant strains have a certain degree of antagonism to traditional drugs and most vaccines. Although most vaccines have great anti-epidemic properties and have important and irreplaceable effects and protection for prevention and treatment, it is impossible to completely prevent the spread and infection of viruses. The spread of the new crown virus pneumonia has been delayed for nearly two years. There are hundreds of millions of people infected worldwide, millions of deaths, and the time is long, the spread is widespread, and billions of people around the world are among them. The harm of the virus is quite terrible. This is well known. of. More urgent

What is more serious is that the virus and mutant strains have not completely retreated, especially many people are still infected and infected after being injected with various vaccines. The effectiveness of the vaccine and the resistance of the mutant virus are worthy of medical scientists, virologists, pharmacologists Zoologists and others seriously think and analyze. The current epidemic situation in European and American countries, China, Brazil, India, the United States, Russia and other countries has greatly improved from last year. However, relevant figures show that the global epidemic situation has not completely improved, and some countries and regions are still very serious. In particular, after extensive use of various vaccines, cases still occur, and in some places they are still very serious, which deserves a high degree of vigilance. Prevention and control measures are very important. In addition, vaccines and various anti-epidemic drugs are the first and necessary choices, and other methods are irreplaceable. It is particularly important to develop and develop comprehensive drugs, antiviral drugs, immune drugs, and genetic drugs. Research experiments on new coronaviruses and mutant viruses require more rigorous and in-depth data analysis, pathological pathogenic tissues, cell genes, molecular chemistry, quantum chemistry, etc., as well as vaccine molecular chemistry, quantum physics, quantum biology, cytological histology, medicinal chemistry, and drugs And the vaccine’s symptomatic, effectiveness, safety, long-term effectiveness, etc., of course, including tens of thousands of clinical cases and deaths and other first-hand information and evidence. The task of RNA (ribonucleic acid) in the human body is to use the information of our genetic material DNA to produce protein. It accomplishes this task in the ribosome, the protein-producing area of the cell. The ribosome is the place where protein biosynthesis occurs.

Medicine takes advantage of this: In vaccination, artificially produced mRNA provides ribosomes with instructions for constructing pathogen antigens to fight against—for example, the spike protein of coronavirus.

Traditional live vaccines or inactivated vaccines contain antigens that cause the immune system to react. The mRNA vaccine is produced in the cell

(1) The specificity of new coronaviruses and mutant viruses, etc., virology and quantum chemistry of mutant viruses, quantum physics, quantum microbiology

(2) New crown vaccine design, molecular biology and chemical structure, etc.

(3) The generality and particularity of the development of new coronavirus drugs

(4) Various drug design for new coronavirus pneumonia, medicinal chemistry, pharmacology, etc., cells, proteins, DNA, enzyme chemistry, pharmaceutical quantum chemistry, pharmaceutical quantum physics, human biochemistry, human biophysics, etc.

(5) The evolution and mutation characteristics of the new coronavirus and various mutant viruses, the long-term nature, repeatability, drug resistance, and epidemic resistance of the virus, etc.

(6) New coronavirus pneumonia and the infectious transmission of various new coronaviruses and their particularities

(7) The invisible transmission of new coronavirus pneumonia and various mutant viruses in humans or animals, and the mutual symbiosis of cross infection of various bacteria and viruses are also one of the very serious causes of serious harm to new coronaviruses and mutant viruses. Virology, pathology, etiology, gene sequencing, gene mapping, and a large number of analytical studies have shown that there are many cases in China, the United States, India, Russia, Brazil, and other countries.

(8) For the symptomatic prevention and treatment of the new coronavirus, the combination of various vaccines and various antiviral drugs is critical.

(9) According to the current epidemic situation and research judgments, the epidemic situation may improve in the next period of time and 2021-2022, and we are optimistic about its success. However, completely worry-free, it is still too early to win easily. It is not just relying on vaccination. Wearing masks to close the city and other prevention and control measures and methods can sit back and relax, and you can win a big victory. Because all kinds of research and exploration still require a lot of time and various experimental studies. It is not a day's work. A simple taste is very dangerous and harmful. The power and migratory explosiveness of viruses sometimes far exceed human thinking and perception. In the future, next year, or in the future, whether viruses and various evolutionary mutation viruses will re-attack, we still need to study, analyze, prevent and control, rather than being complacent, thinking that the vaccine can win a big victory is inevitably naive and ridiculous. Vaccine protection is very important, but it must not be taken carelessly. The mutation of the new crown virus is very rampant, and the cross-infection of recessive and virulent bacteria makes epidemic prevention and anti-epidemic very complicated.

(10) New crown virus pneumonia and the virus's stubbornness, strength, migration, susceptibility, multi-infectiousness, and occult. The effectiveness of various vaccines and the particularity of virus mutations The long-term hidden dangers and repeated recurrences of the new coronavirus

(11) The formation mechanism and invisible transmission of invisible viruses, asymptomatic infections and asymptomatic infections, asymptomatic transmission routes, asymptomatic infections, pathological pathogens. The spread and infection of viruses and mutated viruses, the blind spots and blind spots of virus vaccines, viral quantum chemistry and

The chemical and physical corresponding reactions at the meeting points of highly effective vaccine drugs, etc. The variability of mutated viruses is very complicated, and vaccination cannot completely prevent the spread of infection.

(12) New crown virus pneumonia and various respiratory infectious diseases are susceptible to infections in animals and humans, and are frequently recurring. This is one of the frequently-occurring and difficult diseases of common infectious diseases. Even with various vaccines and various antiviral immune drugs, it is difficult to completely prevent the occurrence and spread of viral pneumonia. Therefore, epidemic prevention and anti-epidemic is a major issue facing human society, and no country should take it lightly. The various costs that humans pay on this issue are very expensive, such as Ebola virus, influenza A virus,

Hepatitis virus,

Marburg virus

Sars coronavirus, plague, anthracnose, cholera

and many more. The B.1.1.7 mutant virus that was first discovered in the UK was renamed Alpha mutant virus; the B.1.351 that was first discovered in South Africa was renamed Beta mutant virus; the P.1 that was first discovered in Brazil was renamed Gamma mutant virus; the mutation was first discovered in India There are two branches of the virus. B.1.617.2, which was listed as "mutated virus of concern", was renamed Delta mutant virus, and B.1.617.1 of "mutated virus to be observed" was renamed Kappa mutant virus.

However, experts in many countries believe that the current vaccination is still effective, at least it can prevent severe illness and reduce deaths.

　　　　 Delta mutant strain

According to the degree of risk, the WHO divides the new crown variant strains into two categories: worrying variant strains (VOC, variant of concern) and noteworthy variant strains (VOI, variant of interest). The former has caused many cases and a wide range of cases worldwide, and data confirms its transmission ability, strong toxicity, high power, complex migration, and high insidious transmission of infection. Resistance to vaccines may lead to the effectiveness of vaccines and clinical treatments. Decrease; the latter has confirmed cases of community transmission worldwide, or has been found in multiple countries, but has not yet formed a large-scale infection. Need to be very vigilant. Various cases and deaths in many countries in the world are related to this. In some countries, the epidemic situation is repeated, and it is also caused by various reasons and viruses, of course, including new cases and so on.

At present, VOC is the mutant strain that has the greatest impact on the epidemic and the greatest threat to the world, including: Alpha, Beta, Gamma and Delta. , Will the change of the spur protein in the VOC affect the immune protection effect of the existing vaccine, or whether it will affect the sensitivity of the VOC to the existing vaccine? For this problem, it is necessary to directly test neutralizing antibodies, such as those that can prevent the protection of infection. Antibodies recognize specific protein sequences on viral particles, especially those spike protein sequences used in mRNA vaccines.

(13) Countries around the world, especially countries and regions with more severe epidemics, have a large number of clinical cases, severe cases, and deaths, especially including many young and middle-aged patients, including those who have been vaccinated. The epidemic is more complicated and serious. Injecting various vaccines, taking strict control measures such as closing the city and wearing masks are very important and the effect is very obvious. However, the new coronavirus and mutant viruses are so repeated, their pathological pathogen research will also be very complicated and difficult. After the large-scale use of the vaccine, many people are still infected. In addition to the lack of prevention and control measures, it is very important that the viability of the new coronavirus and various mutant viruses is very important. It can escape the inactivation of the vaccine. It is very resistant to stubbornness. Therefore, the recurrence of new coronavirus pneumonia is very dangerous. What is more noteworthy is that medical scientists, virologists, pharmacists, biologists, zoologists and clinicians should seriously consider the correspondence between virus specificity and vaccine drugs, and the coupling of commonality and specificity. Only in this way can we find targets. Track and kill viruses. Only in this sense can the new crown virus produce a nemesis, put an end to and eradicate the new crown virus pneumonia. Of course, this is not a temporary battle, but a certain amount of time and process to achieve the goal in the end.

(14) The development and evolution of the natural universe and earth species, as well as life species. With the continuous evolution of human cell genes, microbes and bacterial viruses are constantly mutated and inherited. The new world will inevitably produce a variety of new pathogens.

And viruses. For example, neurological genetic disease, digestive system disease, respiratory system disease, blood system disease, cardiopulmonary system disease, etc., new diseases will continue to emerge as humans develop and evolve. Human migration to space, space diseases, space psychological diseases, space cell diseases, space genetic diseases, etc. Therefore, for the new coronavirus and mutated viruses, we must have sufficient knowledge and response, and do not think that it will be completely wiped out.

, And is not a scientific attitude. Viruses and humans mutually reinforce each other, and viruses and animals and plants mutually reinforce each other. This is the iron law of the natural universe. Human beings can only adapt to natural history, but cannot deliberately modify natural history.

Active immune products made from specific bacteria, viruses, rickettsiae, spirochetes, mycoplasma and other microorganisms and parasites are collectively called vaccines. Vaccination of animals can make the animal body have specific immunity. The principle of vaccines is to artificially attenuate, inactivate, and genetically attenuate pathogenic microorganisms (such as bacteria, viruses, rickettsia, etc.) and their metabolites. Purification and preparation methods, made into immune preparations for the prevention of infectious diseases. In terms of ingredients, the vaccine retains the antigenic properties and other characteristics of the pathogen, which can stimulate the body's immune response and produce protective antibodies. But it has no pathogenicity and does not cause harm to the body. When the body is exposed to this pathogen again, the immune system will produce more antibodies according to the previous memory to prevent the pathogen from invading or to fight against the damage to the body. (1) Inactivated vaccines: select pathogenic microorganisms with strong immunogenicity, culture them, inactivate them by physical or chemical methods, and then purify and prepare them. The virus species used in inactivated vaccines are generally virulent strains, but the use of attenuated attenuated strains also has good immunogenicity, such as the inactivated polio vaccine produced by the Sabin attenuated strain. The inactivated vaccine has lost its infectivity to the body, but still maintains its immunogenicity, which can stimulate the body to produce corresponding immunity and resist the infection of wild strains. Inactivated vaccines have a good immune effect. They can generally be stored for more than one year at 2～8°C without the risk of reversion of virulence; however, the inactivated vaccines cannot grow and reproduce after entering the human body. They stimulate the human body for a short time and must be strong and long-lasting. In general, adjuvants are required for immunity, and multiple injections in large doses are required, and the local immune protection of natural infection is lacking. Including bacteria, viruses, rickettsiae and toxoid preparations.

(2) Live attenuated vaccine: It is a vaccine made by using artificial targeted mutation methods or by screening live microorganisms with highly weakened or basically non-toxic virulence from the natural world. After inoculation, the live attenuated vaccine has a certain ability to grow and reproduce in the body, which can cause the body to have a reaction similar to a recessive infection or a mild infection, and it is widely used.

(3) Subunit vaccine: Among the multiple specific antigenic determinants carried by macromolecular antigens, only a small number of antigenic sites play an important role in the protective immune response. Separate natural proteins through chemical decomposition or controlled proteolysis, and extract bacteria and virusesVaccines made from fragments with immunological activity are screened out of the special protein structure of, called subunit vaccines. Subunit vaccines have only a few major surface proteins, so they can eliminate antibodies induced by many unrelated antigens, thereby reducing the side effects of the vaccine and related diseases and other side effects caused by the vaccine. (4) Genetically engineered vaccine: It uses DNA recombination biotechnology to direct the natural or synthetic genetic material in the pathogen coat protein that can induce the body's immune response into bacteria, yeast or mammalian cells to make it fully expressed. A vaccine prepared after purification. The application of genetic engineering technology can produce subunit vaccines that do not contain infectious substances, stable attenuated vaccines with live viruses as carriers, and multivalent vaccines that can prevent multiple diseases. This is the second-generation vaccine following the first-generation traditional vaccine. It has the advantages of safety, effectiveness, long-term immune response, and easy realization of combined immunization. It has certain advantages and effects.

New coronavirus drug development, drug targets and chemical modification.

Ligand-based drug design (or indirect drug design planning) relies on the knowledge of other molecules that bind to the target biological target. These other molecules can be used to derive pharmacophore models and structural modalities, which define the minimum necessary structural features that the molecule must have in order to bind to the target. In other words, a model of a biological target can be established based on the knowledge of the binding target, and the model can be used to design new molecular entities and other parts that interact with the target. Among them, the quantitative structure-activity relationship (QSAR) is included, in which the correlation between the calculated properties of the molecule and its experimentally determined biological activity can be derived. These QSAR relationships can be used to predict the activity of new analogs. The structure-activity relationship is very complicated.

Based on structure

Structure-based drug design relies on knowledge of the three-dimensional structure of biological targets obtained by methods such as X-ray crystallography or NMR spectroscopy and quantum chemistry. If the experimental structure of the target is not available, it is possible to create a homology model of the target and other standard models that can be compared based on the experimental structure of the relevant protein. Using the structure of biological targets, interactive graphics and medical chemists’ intuitive design can be used to predict drug candidates with high affinity and selective binding to the target. Various automatic calculation programs can also be used to suggest new drug candidates.

The current structure-based drug design methods can be roughly divided into three categories. The 3D method is to search a large database of small molecule 3D structures to find new ligands for a given receptor, in order to use a rapid approximate docking procedure to find those suitable for the receptor binding pocket. This method is called virtual screening. The second category is the de novo design of new ligands. In this method, by gradually assembling small fragments, a ligand molecule is established within the constraints of the binding pocket. These fragments can be single atoms or molecular fragments. The main advantage of this method is that it can propose novel structures that are not found in any database. The third method is to optimize the known ligand acquisition by evaluating the proposed analogs in the binding cavity.

Bind site ID

Binding site recognition is a step in structure-based design. If the structure of the target or a sufficiently similar homologue is determined in the presence of the bound ligand, the ligand should be observable in that structure, in which case the location of the binding site is small. However, there may not be an allosteric binding site of interest. In addition, only apo protein structures may be available, and it is not easy to reliably identify unoccupied sites that have the potential to bind ligands with high affinity. In short, the recognition of binding sites usually depends on the recognition of pits. The protein on the protein surface can hold molecules the size of drugs, etc. These molecules also have appropriate "hot spots" that drive ligand binding, hydrophobic surfaces, hydrogen bonding sites, and so on.

Drug design is a creative process of finding new drugs based on the knowledge of biological targets. The most common type of drug is small organic molecules that activate or inhibit the function of biomolecules, thereby producing therapeutic benefits for patients. In the most important sense, drug design involves the design of molecules with complementary shapes and charges that bind to their interacting biomolecular targets, and therefore will bind to them. Drug design often but does not necessarily rely on computer modeling techniques. A more accurate term is ligand design. Although the design technology for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, etc., which must be optimized first before the ligand can become safe and effective. drug. These other features are usually difficult to predict and realize through reasonable design techniques. However, due to the high turnover rate, especially in the clinical stage of drug development, in the early stage of the drug design process, more attention is paid to the selection of drug candidates. The physical and chemical properties of these drug candidates are expected to be reduced during the development process. Complications are therefore more likely to lead to the approval of the marketed drug. In addition, in early drug discovery, in vitro experiments with computational methods are increasingly used to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological characteristics. A more accurate term is ligand design. Although the design technique for predicting binding affinity is quite successful, there are many other characteristics, such as bioavailability, metabolic half-life, side effects, iatrogenic effects, etc., which must be optimized first, and then the ligand To become safe and effective.

For drug targets, two aspects should be considered when selecting drug targets:

1. The effectiveness of the target, that is, the target is indeed related to the disease, and the symptoms of the disease can be effectively improved by regulating the physiological activity of the target.

2. The side effects of the target. If the regulation of the physiological activity of the target inevitably produces serious side effects, it is inappropriate to select it as the target of drug action or lose its important biological activity. The reference frame of the target should be expanded in multiple dimensions to have a big choice.

3. Search for biomolecular clues related to diseases: use genomics, proteomics and biochip technology to obtain biomolecular information related to diseases, and perform bioinformatics analysis to obtain clue information.

4. Perform functional research on related biomolecules to determine the target of candidate drugs. Multiple targets or individual targets.

5. Candidate drug targets, design small molecule compounds, and conduct pharmacological research at the molecular, cellular and overall animal levels.

Covalent bonding type

The covalent bonding type is an irreversible form of bonding, similar to the organic synthesis reaction that occurs. Covalent bonding types mostly occur in the mechanism of action of chemotherapeutic drugs. For example, alkylating agent anti-tumor drugs produce covalent bonding bonds to guanine bases in DNA, resulting in cytotoxic activity.

. Verify the effectiveness of the target.

Based on the targets that interact with drugs, that is, receptors in a broad sense, such as enzymes, receptors, ion channels, membranes, antigens, viruses, nucleic acids, polysaccharides, proteins, enzymes, etc., find and design reasonable drug molecules. Targets of action and drug screening should focus on multiple points. Drug intermediates and chemical modification. Combining the development of new drugs with the chemical structure modification of traditional drugs makes it easier to find breakthroughs and develop new antiviral drugs. For example, careful selection, modification and modification of existing related drugs that can successfully treat and recover a large number of cases, elimination and screening of invalid drugs from severe death cases, etc., are targeted, rather than screening and capturing needles in a haystack, aimless, with half the effort. Vaccine design should also be multi-pronged and focused. The broad-spectrum, long-term, safety, efficiency and redundancy of the vaccine should all be considered. In this way, it will be more powerful to deal with the mutation and evolution of the virus. Of course, series of vaccines, series of drugs, second-generation vaccines, third-generation vaccines, second-generation drugs, third-generation drugs, etc. can also be developed. Vaccines focus on epidemic prevention, and medicines focus on medical treatment. The two are very different; however, the two complement each other and complement each other. Therefore, in response to large-scale epidemics of infectious diseases, vaccines and various drugs are the nemesis and killers of viral diseases. Of course, it also includes other methods and measures, so I won't repeat them here.

Mainly through the comprehensive and accurate understanding of the structure of the drug and the receptor at the molecular level and even the electronic level, structure-based drug design and the understanding of the structure, function, and drug action mode of the target and the mechanism of physiological activity Mechanism-based drug design.

Compared with the traditional extensive pharmacological screening and lead compound optimization, it has obvious advantages.

Viral RNA replicase, also known as RNA-dependent RNA polymerase (RdRp) is responsible for the replication and transcription of RNA virus genome, and plays a very important role in the process of virus self-replication in host cells, and It also has a major impact on the mutation of the virus, it will change and accelerate the replication and recombination. Because RdRp from different viruses has a highly conserved core structure, the virus replicase is an important antiviral drug target and there are other selection sites, rather than a single isolated target target such as the new coronavirus As with various mutant viruses, inhibitors developed for viral replicase are expected to become a broad-spectrum antiviral drug. The currently well-known anti-coronavirus drug remdesivir (remdesivir) is a drug for viral replicase.

New antiviral therapies are gradually emerging. In addition to traditional polymerase and protease inhibitors, nucleic acid drugs, cell entry inhibitors, nucleocapsid inhibitors, and drugs targeting host cells are also increasingly appearing in the research and development of major pharmaceutical companies. The treatment of mutated viruses is becoming increasingly urgent. The development of drugs for the new coronavirus pneumonia is very important. It is not only for the current global new coronavirus epidemic, but more importantly, it is of great significance to face the severe pneumonia-respiratory infectious disease that poses a huge threat to humans.

There are many vaccines and related drugs developed for the new coronavirus pneumonia, and countries are vying for a while, mainly including the following:

Identification test, appearance, difference in loading, moisture, pH value, osmolality, polysaccharide content, free polysaccharide content, potency test, sterility test, pyrogen test, bacterial endotoxin test, abnormal toxicity test.

Among them: such as sterility inspection, pyrogen inspection, bacterial endotoxin, and abnormal toxicity inspection are indicators closely related to safety.

Polysaccharide content, free polysaccharide content, and efficacy test are indicators closely related to vaccine effectiveness.

Usually, a vaccine will go through a long research and development process of at least 8 years or even more than 20 years from research and development to marketing. The outbreak of the new crown epidemic requires no delay, and the design and development of vaccines is speeding up. It is not surprising in this special period. Of course, it is understandable that vaccine design, development and testing can be accelerated, shortened the cycle, and reduced some procedures. However, science needs to be rigorous and rigorous to achieve great results. The safety and effectiveness of vaccines are of the utmost importance. There must not be a single error. Otherwise, it will be counterproductive and need to be continuously improved and perfected.

Pre-clinical research: The screening of strains and cells is the basic guarantee to ensure the safety, effectiveness, and continuous supply of vaccines. Taking virus vaccines as an example, the laboratory stage needs to carry out strain screening, necessary strain attenuation, strain adaptation to the cultured cell matrix and stability studies in the process of passaging, and explore the stability of process quality, establish animal models, etc. . Choose mice, guinea pigs, rabbits or monkeys for animal experiments according to each vaccine situation. Pre-clinical research generally takes 5-10 years or longer on the premise that the process is controllable, the quality is stable, and it is safe and effective. In order to be safe and effective, a certain redundant design is also needed, so that the safety and effectiveness of the vaccine can be importantly guaranteed.

These include the establishment of vaccine strain/cell seed bank, production process research, quality research, stability research, animal safety evaluation and effectiveness evaluation, and clinical trial programs, etc.

The ARS-CoV-2 genome contains at least 10 ORFs. ORF1ab is converted into a polyprotein and processed into 16 non-structural proteins (NSP). These NSPs have a variety of functional biological activities, physical and chemical reactions, such as genome replication, induction of host mRNA cleavage, membrane rearrangement, autophagosome production, NSP polyprotein cleavage, capping, tailing, methylation, RNA double-stranded Uncoiling, etc., and others, play an important role in the virus life cycle. In addition, SARS-CoV-2 contains 4 structural proteins, namely spike (S), nucleocapsid (N), envelope (E) and membrane (M), all of which are encoded by the 3'end of the viral genome. Among the four structural proteins, S protein is a large multifunctional transmembrane protein that plays an important role in the process of virus adsorption, fusion, and injection into host cells, and requires in-depth observation and research.

1S protein is composed of S1 and S2 subunits, and each subunit can be further divided into different functional domains. The S1 subunit has 2 domains: NTD and RBD, and RBD contains conservative RBM. The S2 subunit has 3 structural domains: FP, HR1 and HR2. The S1 subunit is arranged at the top of the S2 subunit to form an immunodominant S protein.

The virus uses the host transmembrane protease Serine 2 (TMPRSS2) and the endosomal cysteine protease CatB/L to enter the cell. TMPRSS2 is responsible for the cleavage of the S protein to expose the FP region of the S2 subunit, which is responsible for initiating endosome-mediated host cell entry into it. It shows that TMPRSS2 is a host factor necessary for virus entry. Therefore, the use of drugs that inhibit this protease can achieve the purpose of treatment.

mRNA-1273

The mRNA encoding the full length of SARS-CoV-2, and the pre-spike protein fusion is encapsulated into lipid nanoparticles to form mRNA-1273 vaccine. It can induce a high level of S protein specific antiviral response. It can also consist of inactivated antigens or subunit antigens. The vaccine was quickly approved by the FDA and has entered phase II clinical trials. The company has announced the antibody data of 8 subjects who received different immunization doses. The 25ug dose group achieved an effect similar to the antibody level during the recovery period. The 100ug dose group exceeded the antibody level during the recovery period. In the 25ug and 100ug dose groups, the vaccine was basically safe and tolerable, while the 250ug dose group had 3 levels of systemic symptoms.

Viral vector vaccines can provide long-term high-level expression of antigen proteins, induce CTLs, and ultimately eliminate viral infections.

1, Ad5-nCov

A vaccine of SARS-CoV-2 recombinant spike protein expressed by recombinant, replication-deficient type 5 adenovirus (Ad5) vector. Load the optimized full-length S protein gene together with the plasminogen activation signal peptide gene into the E1 and E3 deleted Ad5 vectors. The vaccine is constructed by the Admax system derived from Microbix Biosystem. In phase I clinical trials, RBD (S1 subunit receptor binding domain) and S protein neutralizing antibody increased by 4 times 14 days after immunization, reaching a peak on 28 days. CD4+T and CD8+T cells reached a peak 14 days after immunization. The existing Ad5 immune resistance partially limits the response of antibodies and T cells. This study will be further conducted in the 18-60 age group, receiving 1/3 of the study dose, and follow-up for 3-6 months after immunization.

DNA vaccine

The introduction of antigen-encoding DNA and adjuvants as vaccines is the most innovative vaccine method. The transfected cells stably express the transgenic protein, similar to live viruses. The antigen will be endocytosed by immature DC, and finally provide antigen to CD4 + T, CD8 + T cells (by MHC differentiation) To induce humoral and cellular immunity. Some specificities of the virus and the new coronavirus mutant are different from general vaccines and other vaccines. Therefore, it is worth noting the gene expression of the vaccine. Otherwise, the effectiveness and efficiency of the vaccine will be questioned.

Live attenuated vaccine

DelNS1-SARS-CoV2-RBD

Basic influenza vaccine, delete NS1 gene. Express SARS-CoV-2 RBD domain. Cultured in CEF and MDCK (canine kidney cells) cells. It is more immunogenic than wild-type influenza virus and can be administered by nasal spray.

The viral genome is susceptible to mutation, antigen transfer and drift can occur, and spread among the population. Mutations can vary depending on the environmental conditions and population density of the geographic area. After screening and comparing 7,500 samples of infected patients, scientists found 198 mutations, indicating the evolutionary mutation of the virus in the human host. These mutations may form different virus subtypes, which means that even after vaccine immunization, viral infections may occur. A certain amount of increment and strengthening is needed here.

Inactivated vaccines, adenovirus vector vaccines, recombinant protein vaccines, nucleic acid vaccines, attenuated influenza virus vector vaccines, etc. According to relevant information, there are dozens of new coronavirus vaccines in the world, and more varieties are being developed and upgraded. Including the United States, Britain, China, Russia, India and other countries, there are more R&D and production units.

AZ vaccine

Modena vaccine

Lianya Vaccine

High-end vaccine

Pfizer vaccine

Pfizer-BioNTech

A large study found that the vaccine developed by Pfizer and German biotechnology company BioNTech is 95% effective in preventing COVID-19.

The vaccine is divided into two doses, which are injected every three weeks.

This vaccine uses a molecule called mRNA as its basis. mRNA is a molecular cousin of DNA, which contains instructions to build specific proteins; in this case, the mRNA in the vaccine encodes the coronavirus spike protein, which is attached to the surface of the virus and used to infect human cells. Once the vaccine enters the human body, it will instruct the body's cells to make this protein, and the immune system will learn to recognize and attack it.

Moderna

The vaccine developed by the American biotechnology company Moderna and the National Institute of Allergy and Infectious Diseases (NIAID) is also based on mRNA and is estimated to be 94.5% effective in preventing COVID-19.

Like Pfizer's vaccine, this vaccine is divided into two doses, but injected every four weeks instead of three weeks. Another difference is that the Moderna vaccine can be stored at minus 20 degrees Celsius instead of deep freezing like Pfizer vaccine. At present, the importance of one of the widely used vaccines is self-evident.

Oxford-AstraZeneca

The vaccine developed by the University of Oxford and the pharmaceutical company AstraZeneca is approximately 70% effective in preventing COVID-19-that is, in clinical trials, adjusting the dose seems to improve this effect.

In the population who received two high-dose vaccines (28 days apart), the effectiveness of the vaccine was about 62%; according to early analysis, the effectiveness of the vaccine in those patients who received the half-dose first and then the full-dose Is 90%. However, in clinical trials, participants taking half doses of the drug are wrong, and some scientists question whether these early results are representative.

Sinopharm Group (Beijing Institute of Biological Products, China)

China National Pharmaceutical Group Sinopharm and Beijing Institute of Biological Products have developed a vaccine from inactivated coronavirus (SARS-CoV-2). The inactivated coronavirus is an improved version that cannot be replicated.

Estimates of the effectiveness of vaccines against COVID-19 vary.

Gamaleya Institute

The Gamaleya Institute of the Russian Ministry of Health has developed a coronavirus vaccine candidate called Sputnik V. This vaccine contains two common cold viruses, adenoviruses, which have been modified so that they will not replicate in the human body; the modified virus also contains a gene encoding the coronavirus spike protein.

New crown drugs

There are many small molecule antiviral drug candidates in the clinical research stage around the world. Including traditional drugs in the past and various drugs yet to be developed, antiviral drugs, immune drugs, Gene drugs, compound drugs, etc.

(A) Molnupiravir

Molnupiravir is a prodrug of the nucleoside analog N4-hydroxycytidine (NHC), jointly developed by Merck and Ridgeback Biotherapeutics.

The positive rate of infectious virus isolation and culture in nasopharyngeal swabs was 0% (0/47), while that of patients in the placebo group was 24% (6/25). However, data from the Phase II/III study indicate that the drug has no benefit in preventing death or shortening the length of stay in hospitalized patients.

Therefore, Merck has decided to fully advance the research of 800mg molnupiravir in the treatment of patients with mild to moderate COVID-19.

(B) AT-527

AT-527 is a small molecule inhibitor of viral RNA polymerase, jointly developed by Roche and Atea. Not only can it be used as an oral therapy to treat hospitalized COVID-19 patients, but it also has the potential as a preventive treatment after exposure.

Including 70 high-risk COVID-19 hospitalized patients data, of which 62 patients' data can be used for virological analysis and evaluation. The results of interim virological analysis show that AT-527 can quickly reduce viral load. On day 2, compared with placebo, patients treated with AT-527 had a greater decline in viral load than the baseline level, and the continuous difference in viral load decline was maintained until day 8.

In addition, compared with the control group, the potent antiviral activity of AT-527 was also observed in patients with a baseline median viral load higher than 5.26 log10. When testing by RT-qPCR to assess whether the virus is cleared,

The safety aspect is consistent with previous studies. AT-527 showed good safety and tolerability, and no new safety problems or risks were found. Of course, there is still a considerable distance between experiment and clinical application, and a large amount of experimental data can prove it.

Prokalamide is an AR (androgen receptor) antagonist. Activated androgen receptor AR can induce the expression of transmembrane serine protease (TMPRSS2). TMPRSS2 has a shearing effect on the new coronavirus S protein and ACE2, which can promote the binding of viral spike protein (S protein) to ACE, thereby promoting The virus enters the host cell. Therefore, inhibiting the androgen receptor may inhibit the viral infection process, and AR antagonists are expected to become anti-coronavirus drugs.

Positive results were obtained in a randomized, double-blind, placebo-controlled phase III clinical trial. The data shows that Prokalutamide reduces the risk of death in severely ill patients with new coronary disease by 92%, reduces the risk of new ventilator use by 92%, and shortens the length of hospital stay by 9 days. This shows that procrulamide has a certain therapeutic effect for patients with severe new coronary disease, which can significantly reduce the mortality of patients, and at the same time greatly reduce the new mechanical ventilation and shorten the patient's hospital stay.

With the continuous development of COVID-19 on a global scale, in addition to vaccines and prevention and control measures, we need a multi-pronged plan to control this disease. Oral antiviral therapy undoubtedly provides a convenient treatment option.

In addition, there are other drugs under development and experimentation. In dealing with the plague virus, in addition to the strict control of protective measures, it is very important that various efficient and safe vaccines and various drugs (including medical instruments, etc.) are the ultimate nemesis and killer of the virus.

(A) "Antiviral biological missiles" are mainly drugs for new coronaviruses and mutant viruses, which act on respiratory and lung diseases. The drugs use redundant designs to inhibit new coronaviruses and variant viruses.

(B) "New Coronavirus Epidemic Prevention Tablets" mainly use natural purified elements and chemical structure modifications.

(D) "New Coronavirus Long-acting Oral Tablets" Chemical modification of antiviral drugs, multiple targets, etc.

(E) "New Coronavirus Inhibitors" (injections) are mainly made of chemical drug structure modification and other preparations.

The development of these drugs mainly includes: drug target screening, structure-activity relationship, chemical modification, natural purification, etc., which require a lot of work and experimentation.

Humans need to vigorously develop drugs to deal with various viruses. These drugs are very important for the prevention and treatment of viruses and respiratory infectious diseases, influenza, pneumonia, etc.

The history of human development The history of human evolution, like all living species, will always be accompanied by the survival and development of microorganisms. It is not surprising that viruses and infectious diseases are frequent and prone to occur. The key is to prevent and control them before they happen.

This strain was first discovered in India in October 2020 and was initially called a "double mutant" virus by the media. According to the announcement by the Ministry of Health of India at the end of March this year, the "India New Coronavirus Genomics Alliance" composed of 10 laboratories found in samples collected in Maharashtra that this new mutant strain carries E484Q and L452R mutations. , May lead to immune escape and increased infectivity. This mutant strain was named B.1.617 by the WHO and was named with the Greek letter δ (delta) on May 31.

Shahid Jamil, the dean of the Trivedi School of Biological Sciences at Ashoka University in India and a virologist, said in an interview with the Shillong Times of India that this mutant strain called "double mutation" is not accurate enough. B. 1.617 contains a total of 15 mutations, of which 6 occur on the spike protein, of which 3 are more critical: L452R and E484Q mutations occur on the spike protein and the human cell "Angiotensin Converting Enzyme 2 (ACE2)" receptor In the bound region, L452R improves the ability of the virus to invade cells, and E484Q helps to enhance the immune escape of the virus; the third mutation P681R can also make the virus enter the cell more effectively. (Encyclopedia website)

There are currently dozens of antiviral COVID-19 therapies under development. The large drugmakers Merck and Pfizer are the closest to the end, as expected, a pair of oral antiviral COVID-19 therapies are undergoing advanced human clinical trials.

Merck's drug candidate is called monupiravir. It was originally developed as an influenza antiviral drug several years ago. However, preclinical studies have shown that it has a good effect on SARS and MERS coronavirus.

Monupiravir is currently undergoing in-depth large-scale Phase 3 human trials. So far, the data is so promising that the US government recently pre-ordered 1.7 million courses of drugs at a cost of $1.2 billion. If everything goes according to plan, the company hopes that the drug will be authorized by the FDA for emergency use and be on the market before the end of 2021.

Pfizer's large COVID-19 antiviral drug candidate is more unique. Currently known as PF-07321332, this drug is the first oral antiviral drug to enter human clinical trials, specifically targeting SARS-CoV-2.

Variant of Concern WHO Label First Detected in World First Detected in Washington State

B.1.1.7 Alpha United Kingdom, September 2020 January 2021

B.1.351 Beta South Africa, December 2020 February 2021

P.1 Gamma Brazil, April 2020 March 2021

B.1.617.2 Delta India, October 2020 April 2021

Although this particular molecule was developed in 2020 after the emergence of the new coronavirus, a somewhat related drug called PF-00835231 has been in operation for several years, targeting the original SARS virus. However, the new drug candidate PF-07321332 is designed as a simple pill that can be taken under non-hospital conditions in the initial stages of SARS-CoV-2 infection.

"The protease inhibitor binds to a viral enzyme and prevents the virus from replicating in the cell," Pfizer said when explaining the mechanism of its new antiviral drug. "Protease inhibitors have been effective in the treatment of other viral pathogens, such as HIV and hepatitis C virus, whether used alone or in combination with other antiviral drugs. Currently marketed therapeutic drugs for viral proteases are generally not toxic Therefore, such molecules may provide well-tolerated treatments against COVID-19."

Various studies on other types of antiviral drugs are also gaining momentum. For example, the new coronavirus pneumonia "antiviral biological missile", "new coronavirus prevention tablets", "composite antiviral oral liquid", "new coronavirus long-acting oral tablets", "new coronavirus inhibitors" (injections), etc., are worthy of attention. Like all kinds of vaccines, they will play a major role in preventing and fighting epidemics.

In addition, Japanese pharmaceutical company Shionoyoshi Pharmaceutical is currently conducting a phase 1 trial of a protease inhibitor similar to SARS-CoV-2. This is called S-217622, which is another oral antiviral drug, and hopes to provide people with an easy-to-take pill in the early stages of COVID-19. At present, the research and development of vaccines and various new crown drugs is very active and urgent. Time does not wait. With the passage of time, various new crown drugs will appear on the stage one after another, bringing the gospel to the complete victory of mankind.

The COVID-19 pandemic is far from over. The Delta mutant strain has quickly become the most prominent SARS-CoV-2 strain in the world. Although our vaccine is still maintained, it is clear that we need more tools to combat this new type of coronavirus. Delta will certainly not be the last new SARS-CoV-2 variant we encountered. Therefore, it is necessary for all mankind to persevere and fight the epidemic together.

Overcome illness and meet new challenges. The new crown epidemic and various mutated viruses are very important global epidemic prevention and anti-epidemic top priorities, especially for the current period of time. Vaccine injections, research and development of new drugs, strict prevention and control, wear masks, reduce gatherings, strictly control large gatherings, prevent the spread of various viruses Masks, disinfection and sterilization, lockdown of the city, vaccinations, accounting and testing are very important, but this does not mean that humans can completely overcome the virus. In fact, many spreading and new latently transmitted infections are still unsuccessful. There are detections, such as invisible patients, asymptomatic patients, migratory latent patients, new-onset patients, etc. The struggle between humans and the virus is still very difficult and complicated, and long-term efforts and exploration are still needed, especially for medical research on the new coronavirus. The origin of the disease, the course of the disease, the virus invaded The deep-level path and the reasons for the evolution and mutation of the new coronavirus and the particularity of prevention and treatment, etc.). Therefore, human beings should be highly vigilant and must not be taken lightly. The fierce battle between humans and various viruses must not be slackened. Greater efforts are needed to successfully overcome this pandemic, fully restore the normal life of the whole society, restore the normal production and work order, restore the normal operation of society, economy and culture, and give up food due to choking. Or eager for success, will pay a high price.

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Compilation postscript

Once Fang Ruida's research literature on the new crown virus and mutant virus was published, it has been enthusiastically praised by readers and netizens in dozens of countries around the world, and has proposed some amendments and suggestions. Hope to publish a multilingual version of the book as an emergency To meet the needs of many readers around the world, in the face of the new crown epidemic and the prevention and treatment of various mutant viruses, including the general public, college and middle school students, medical workers, medical colleagues and so on. According to the English original manuscript, it will be re-compiled and published. Inconsistencies will be revised separately. Thank you very much.

Jacques Lucy, Geneva, Switzerland, August 2021

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Leader mondial, scientifique, scientifique médical, virologue, pharmacien et professeur Fangruida (F.D Smith) sur l'épidémie mondiale et l'ennemi juré et la prévention des nouveaux coronavirus et virus mutants (Jacques Lucy 2021v1.5)

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L'ennemi juré et le tueur du nouveau coronavirus et des virus mutés - Développement conjoint de vaccins et de médicaments (Fangruida) Juillet 2021

* La particularité des nouveaux coronavirus et des virus mutants * Le large spectre, la haute efficacité, la redondance et la sécurité de la conception et du développement du nouveau vaccin contre le coronavirus, Redondance et sécurité

* Nouvelle modification de la structure chimique des médicaments contre les coronavirus * Conception et dépistage des médicaments assistés par ordinateur. *"Missile biologique antiviral", "Nouveaux comprimés anti-épidémiques contre le coronavirus", "Liquide oral antiviral composite", "Nouveaux comprimés oraux à action prolongée contre le coronavirus", "Nouveaux inhibiteurs de coronavirus" (injection)

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(leader mondial, scientifique, scientifique médical, biologiste, virologue, pharmacien, FD Smith) "The Nemesis and Killer of New Coronavirus and Mutated Viruses-The Joint Development of Vaccines and Drugs" est un important document de recherche scientifique. Il a maintenant été révisé et réédité par l'auteur original à plusieurs reprises. La compilation est publiée et publiée selon le manuscrit original pour répondre aux besoins des lecteurs et des internautes du monde entier. En même temps, elle est également très bénéfique pour le grand nombre de chercheurs en médicaments cliniques médicaux et de divers experts et universitaires. Nous espérons qu'il sera corrigé dans la réimpression.------Compilé par Jacques Lucy à Genève, août 2021

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Selon les statistiques en temps réel de Worldometer, vers 6h30 le 23 juillet, il y avait un total de 193 323 815 cas confirmés de nouvelle pneumonie coronarienne dans le monde, et un total de 4 150 213 décès. Il y a eu 570 902 nouveaux cas confirmés et 8 766 nouveaux décès dans le monde en une seule journée. Les données montrent que les États-Unis, le Brésil, le Royaume-Uni, l'Inde et l'Indonésie sont les cinq pays avec le plus grand nombre de nouveaux cas confirmés, et l'Indonésie, le Brésil, la Russie, l'Afrique du Sud et l'Inde sont les cinq pays avec le plus grand nombre de nouveaux décès.

Les nouvelles souches de coronavirus et de mutants delta ont été particulièrement graves ces derniers temps. De nombreux pays et lieux ont repris vie et le nombre de cas n'a pas diminué, mais a augmenté.

, Il est digne de vigilance. Bien que de nombreux pays aient renforcé la prévention et le contrôle des vaccins et d'autres mesures de prévention et de contrôle, il existe encore de nombreuses lacunes et carences dans la suppression et la prévention du virus. Le nouveau coronavirus et diverses souches mutantes présentent un certain degré d'antagonisme par rapport aux médicaments traditionnels et à la plupart des vaccins. Bien que la plupart des vaccins aient de grandes propriétés anti-épidémiques et aient des effets et une protection importants et irremplaçables pour la prévention et le traitement, il est impossible d'empêcher complètement la propagation et l'infection des virus. La propagation de la nouvelle pneumonie à virus couronne a été retardée de près de deux ans. Il y a des centaines de millions de personnes infectées dans le monde, des millions de décès, et le temps est long, la propagation est généralisée et des milliards de personnes dans le monde sont parmi Les dommages causés par le virus sont assez terribles, c'est bien connu. Plus urgent

Ce qui est plus grave, c'est que le virus et les souches mutantes n'ont pas complètement reculé, surtout que de nombreuses personnes sont encore infectées et infectées après avoir été injectées avec divers vaccins.L'efficacité du vaccin et la résistance du virus mutant sont dignes des scientifiques médicaux, virologues , les pharmacologues Les zoologistes et autres réfléchissent et analysent sérieusement. La situation épidémique actuelle dans les pays européens et américains, la Chine, le Brésil, l'Inde, les États-Unis, la Russie et d'autres pays s'est considérablement améliorée par rapport à l'année dernière.Cependant, les chiffres pertinents montrent que la situation épidémique mondiale ne s'est pas complètement améliorée, et certains pays et régions sont encore très graves. En particulier, après une utilisation intensive de divers vaccins, des cas surviennent encore, et dans certains endroits ils sont encore très graves, ce qui mérite une grande vigilance. Les mesures de prévention et de contrôle sont très importantes.De plus, les vaccins et divers médicaments antiépidémiques sont les premiers choix nécessaires, et les autres méthodes sont irremplaçables. Il est particulièrement important de développer et de développer des médicaments complets, des médicaments antiviraux, des médicaments immunitaires et des médicaments génétiques. Les expériences de recherche sur les nouveaux coronavirus et virus mutants nécessitent une analyse plus rigoureuse et approfondie des données, des tissus pathogènes pathologiques, des gènes cellulaires, de la chimie moléculaire, de la chimie quantique, etc., ainsi que de la chimie moléculaire des vaccins, de la physique quantique, de la biologie quantique, de l'histologie cytologique, la chimie médicinale et les médicaments Et les symptômes, l'efficacité, la sécurité, l'efficacité à long terme, etc. du vaccin, bien sûr, y compris des dizaines de milliers de cas cliniques et de décès et d'autres informations et preuves de première main. La tâche de l'ARN (acide ribonucléique) dans le corps humain est d'utiliser les informations de notre matériel génétique ADN pour produire des protéines. Il accomplit cette tâche dans le ribosome, la zone productrice de protéines de la cellule. Le ribosome est le lieu où se produit la biosynthèse des protéines.

La médecine en profite : dans la vaccination, l'ARNm produit artificiellement fournit aux ribosomes des instructions pour construire des antigènes pathogènes contre lesquels lutter, par exemple, la protéine de pointe du coronavirus.

Les vaccins vivants traditionnels ou les vaccins inactivés contiennent des antigènes qui provoquent la réaction du système immunitaire. Le vaccin à ARNm est produit dans la cellule

(1) La spécificité des nouveaux coronavirus et virus mutants, etc., virologie et chimie quantique des virus mutants, physique quantique, microbiologie quantique

(2) Nouvelle conception de vaccin couronne, biologie moléculaire et structure chimique, etc.

(3) La généralité et la particularité du développement de nouveaux médicaments contre le coronavirus

(4) Diverses conceptions de médicaments pour la pneumonie à nouveau coronavirus, la chimie médicinale, la pharmacologie, etc., les cellules, les protéines, l'ADN, la chimie des enzymes, la chimie quantique pharmaceutique, la physique quantique pharmaceutique, la biochimie humaine, la biophysique humaine, etc.

(5) Les caractéristiques d'évolution et de mutation du nouveau coronavirus et de divers virus mutants, la nature à long terme, la répétabilité, la résistance aux médicaments et la résistance épidémique du virus, etc.

(6) Pneumonie à nouveau coronavirus et transmission infectieuse de divers nouveaux coronavirus et leurs particularités

(7) La transmission invisible de la pneumonie à nouveau coronavirus et de divers virus mutants chez l'homme ou l'animal, et la symbiose mutuelle de l'infection croisée de diverses bactéries et virus sont également l'une des causes très graves de dommages graves aux nouveaux coronavirus et virus mutants. La virologie, la pathologie, l'étiologie, le séquençage des gènes, la cartographie des gènes et un grand nombre d'études analytiques ont montré qu'il existe de nombreux cas en Chine, aux États-Unis, en Inde, en Russie, au Brésil et dans d'autres pays.

(8) Pour la prévention et le traitement symptomatiques du nouveau coronavirus, la combinaison de divers vaccins et de di

Doors of Perception by Dennis van Zuijlekom

One of my little side-projects: photographing doors, in a project I call "Doors of Perception" (yes, I am a fan of The Doors).

Perception by Sourabh Gupta

Perception by David Goehring

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From within, two disagreeing hemispheres.

Perception . . . by Tina Lee Studio

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So, this is what I see when I sit on my front porch - or is it? Bet your first thought was -

wow, she lives in a forest, right? When actually, right beyond the trees is the Atlantic

Intercoastal Waterway and the Bridge to Downtown Beaufort! Amazing views!!!!!

This pic is for my dear Flickr friend John (jssteak) who inspires, encourages and

best of all makes me laugh! His work is beyond incredible - takes the most fantastic tree pics

(and others) so, take a look here: www.flickr.com/photos/jssteak/

View On Black

perceptions by jessica swift

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new painting-- 6x8", india ink, acrylic, linoleum block printing on wood.

available in my etsy shop- see profile for address.

PERCEPTION by Charles Wills

A short film

Perception by SilentArtPhotography

Perception depends on focused attention.. in fascination.

Perception - Near miss ? by Berkut54 ( Clive Bowley )

No, Checking Flight Radar KL682 PH-BQH was at 37,000ft whereas UA932 N782UA was at 38,975ft

Perceptions by InspireFate Photography

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Taken- Beach at Spanish River Park, Boca Raton, FL

Perception by asrai

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Inspired by Through the Looking Glass

Cloud Gate, Anish Kapoor, 2004-2006, Stainless steel

Perception by F-K-L

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The narrowest the perception is the widest the imagination wanders

Dynamic Perception dolly setup by Randy Halverson

Stage Zero dolly setup with "milapse" mount along the White River in SD

Perceptions by jack mckechnie

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This is actual a combination of images of two different streets in our town. I then did a black and white image and the original color image and layered them together to make this image. It kinds of reminds me of that show (Charlie Jade) but with a cheap car. Corel and Exposure 2 was used in each layer. I should also add that the shadow that looks like a huge spider was not planned...but i like it!

Perception by junsjazz

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We do not see nature with our eyes, but with our understandings and our hearts.~William Hazlett

My contribution to the 52nd week of the ImagoismThursday movement. HIT everyone!

Dynamic Perception Stage Zero Dolly by Randy Halverson

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Setup near the White River valley in South Dakota

This was the opening shot in Plains Milky Way

vimeo.com/24551969

perception is everything by Michael Kistler

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Shinsen

November 2010

The Need for New Representational Principles by brewbooks

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Simon Levy presents Vector Symbolic Architectures: A New Building Material for Artificial General Intelligence by Simon Levy of Washington and Lee University and Ross Gayler

(I'd like to take a class from Simon Levy, he is a great teacher from what I could see. Sorry that the photo is poor of him here, but this particular slide mad me think and do quite a bit of homework to increased my understanding of this topic.)

The Need for New Representational Principles

(My notes on this, please feel free to add or clarify anything I have said, it is just my [poor] understanding.)

- Ecological Affordance introduced by James J. Gibson (1979), The Ecological Approach to Visual Perception (an interesting sidebar - this was about the last thing that Gibson published before his death in 1979 at age 75.) A number of his writings are on-line, published as the Purple Perils

- Distributed Connectionist Representations (PDP - which is Parallel Distributed Processing was the start of Connectionism I had colleagues who did research in this area in the early 1990s, at the time I was not as curious as I could have been, being wrapped up in some completely different projects. Now - I have begun to tie it together, funny how that works! The classic work was done by James McClelland, David Rumelhart and the PDP Research Group. They wrote a two volume book: Parallel Distributed Processing: Explorations in the Microstructure of Cognition in 1986)

Holographic Representations Dennis Gabor 1971 and Plate 2003

I probably went down a related area with Karl Pribram's Holonomic brain theory but I need to do some more research about this.

Fractals Attractors Dynamical Systems Tabor 2000 , Levy and Pollack 2001

For a good introduction see Dynamical & Evolutionary Machine Organization part of Jordan Pollack's research at Brandeis University.

In Technical Session # 7: Neural Network and Brain Modeling

Session Chair: Randal Koene , Laboratory of Computational Neurophysiology, Center for Memory and Brain, Boston University at the The First Conference on Artificial General Intelligence (AGI-08)

This room is The Zone, at the FedEx Institute of Technology, University of Memphis. It was a very good venue for this conference.

Artificial General Intelligence (AGI) research focuses on the original and ultimate goal of AI -- to create intelligence as a whole, by exploring all available paths, including theoretical and experimental computer science, cognitive science, neuroscience, and innovative interdisciplinary methodologies. AGI is also called Strong AI in the AI community.

Another good reference is Artificial General Intelligence : A Gentle Introduction Pei Wang

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Perception of Me by Katie Fusco

Saw these E V E R Y W H E R E

so, why not make my own?

Perception #hipstamatic by Belinda

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PERCEPTION by Charles Wills

A short film

Perception by Zara Staples

Perception by Dovaneh

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Perception is strong and sight weak. In strategy it is important to see distant things as if they were close and to take a distanced view of close things.

--Miyamoto Musashi--

Perceptions 2 by Ferran Cubedo

SALE OF PRINTED ARTS > : society6.com/ferrancubedo/Perception-Nature_Framed-Print#...

www.facebook.com/ferrancubedo

ferrancubedo.tumblr.com/

www.flickr.com/photos/78526492@N03/

instagram.com/ferrancubedo

Perception by Graeme Mackay

Door to a secret garden

girl and dog on Yarmouth beach (detail, Emma Blount, 2011) by Simon Knott

St George, Rollesby, Norfolk

A large round-towered church, the 13th Century upper stages of the tower octagonal. The church has one of the best collections of early 20th Century glass in Norfolk.

After my previous visit, ten years before, I'd written, in part: Something extraordinary happened to the Church of England during the middle years of the 19th century. For generations, it had been an arm of the state, the rock upon which the protestant nation was built. But a series of reform acts in the 1820s and 1830s made that rock tremble.

Firstly, many of the administrative functions of the Church were taken away and handed to secular authorities. And then, even worse, Catholicism was decriminalised. Suddenly, it was possible for Christians to worship without owing allegiance to the Crown or to the Bible of non-conformism. Where did the Church of England's identity now subsist? Was it to be sidelined as a mere protestant sect?

A group of academics at Oxford University sprang into action. They called for the re-establishment of Anglicanism as a National Church. They issued a series of tracts, explaining the historic roots of the Church of England, and its self-perception as a Church with an apostolic tradition. Because of this, they became known as the Tractarians, or the Oxford Movement.

The great majority of the British people in the 1830s and 1840s had a serious mistrust of anything that had happened before the 16th century Protestant Reformation. It smacked of Popery; but the Tractarians took on the task of smoothing over the Reformation gap and re-establishing the connection between the 19th century church and its medieval predecessor. They made a spectacularly successful job of this, and as a result the Church of England was changed forever. In just about every parish in the land, Anglican churches were restored to their medieval integrity.

Sacramental chancels were refitted, the old protestant furnishings thrown out, and surviving medieval artefacts rediscovered with alacrity and restored enthusiastically to use. By the 1870s, Anglican churches were once again a riot of colour and ceremony, where only half a century before most had been dull, plain, preaching boxes.

There were, of course, casualties. In seeking out the Catholic medieval roots of the Church, Oxford's academics had also painfully exposed the gap between the modern Church of England and the essential nature of Catholicism. Was it really possible to find a middle way between what Anglicanism believed itself to be, and what it was unable to demonstrate as a reality? Or had the Reformation really been a fracture?

Inevitably, since the touchstone of Catholicism is the Apostolic succession, thousands of people, mainly intellectual and upper-middle class, left the Church of England to be received into the Catholic Church. But the central project of the Tractarians had succeeded. They re-established the Church of England as the spiritual and ceremonial pulse of the Nation.

Tractarianism was fully in the ascendant, becoming Anglo-catholicism as the century progressed, and reaching its peak during the First World War, as the Church provided the triumphalism necessary for the fight, and the authority to mourn for its casualties afterwards.

But the First World War had broken the spell. Reaching a peak in the 1930s, the ceremonies and liturgies of the High Church wing began to ring hollow, and by the 1950s and 1960s the Anglo-catholics were a minority. Newer spiritual currents were running deeper; evangelicalism was undergoing a renaissance, especially in the cities. After the 1992 decision to ordain women as Priests, Anglo-catholicism fragmented; the larger, liberal wing sought out a quieter, more intellectual spirituality. The spiky, militant wing was left to sulk outside the doors of the Church, administered by Flying Bishops and treated as an exotic flower. How much longer can it bloom, or even survive?

And yet, something remains. Because the great wave of restoration in the late 19th and early 20th centuries, handsomely bankrolled as it was by the booming economy and a new, wealthy landed class, produced a massive refurnishing of English churches, not least in the way of stained glass. That the windows are full of coloured glass would be the most startling change a 18th century Anglican would notice if he could visit a church today. In the later 20th century, as Anglo-catholicism retreated, and High Church ceremonial disappeared, the glass remained. And so it does today, often the only surviving evidence of that remarkable time*.

There seems to have been a lot of money about in this part of Norfolk during those years, because the churches were, in the main, extensively restored and furnished. Much of this has gone today, but as I say, the glass remains, and here at Rollesby there is an impressive collection. At Ormesby St Margaret up the road, the medievalisation of the building was paid for by the Lacon brewing family, but here the benefactor was the Rector himself.

The gift of the living, £657 a year, about £130,000 in today's money, was in the hands of the Tacon family, and in 1872 the current owner, Richard John Tacon, presented himself to the living. He was to remain Rector for nearly sixty years, and in that time he would transform the interior of this church. Because of him, St George has one of the largest collections of 19th and 20th Century glass east of Norwich. In this area, only Ormesby St Margaret and Filby have more, and they are much bigger churches than this one.

I mention all this before anything else merely to illustrate the point that English churches are rarely evidence of continuity, but of the drama of violence and ideas. The architectural historian Andy Foster has described history as a palimpsest, but not all historical periods write with equally heavy hands. The character of St George today is almost entirely the work of the Reverend Tacon - and yet, he has been dead eighty years, and virtually nothing in the Church of England remains the same. The liturgy has changed, ideas and attitudes have changed, and certainly the centrality of the church in mainstream English life has changed, and gone for good. And yet still these windows remain.

It was a bright spring day. The blue sky set off beautifully Rollesby's magnificent chancel with its crowning pinnacle figures. The nave, aisles and chancel, unusually for Norfolk, are almost entirely of the Decorated period, the early 14th century, with little of the more familiar Perpendicular architecture of a century and more later. The clerestory in particular is a textbook example of the period. The window tracery is largely Victorian, and the top of the tower probably late 13th century, and possibly contemporary with the building of the nave and chancel. The lower part of the tower is so restored that I found it hard to tell how old it was.

St George has a number of interesting memorials. Reclining at a precarious angle on the north side of the sanctuary is Rose Claxton, in late 16th century dress. She looks rather as if she's just been stuck up the corner because they can't think what else to do with her, poor thing, but her inscription assures us otherwise:

Know Friendly Passenger that this smale roome

Rose Claxton's Body onelye doth intombe.

Her Bewtye, Love & Gracefull Modestye

In her Freinds Hartes shall Lyve Eternallye.

Across from her is Leonard Mapes of Beeston next Norwich with his wife and his children in alabaster, all praying together. He died in 1619, and it looks as if the top of his memorial is missing. Under the tower is a very simple memorial to Hannah Watson, who died in 1810. Just in front of her is the font, one of several local Purbeck marble fonts reset on a collonade. Inside it is a portable font of the sort used by energetic 19th century Rectors.

And there are a couple of curiosities that are worth mentioning. Although the nave and chancel appear broadly contemporary, the arcades do not match up with the chancel. Simply, the chancel is too wide.

What happened here? The obvious answer is that the arcades replaced the walls of an earlier church, and the chancel was built independently of this work. In the south-east corner of the chancel is a very curious structure, a little room built into the sanctuary. It must be a sacristy of some kind - what else could it be? But why is there nothing like it anywhere else in East Anglia?

*Indeed, the tradition continues here with the installation in 2011 of a large window depicting St Raphael on the north side of the chancel, by Emma Blount.

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