View allAll Photos Tagged Internalizing
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
By Jake Maynard and Elena De La Paz
Active throughout the community, Jake and Elena use their skills and knowledge they’ve developed through a personal and constructive relationship with the Reno community and many mutual aid initiatives. They channel these experiences into their artistic practices, working primarily in photography and collage.
Through their pieces showing people both thriving and resisting, they hope to inspire people to think of what's possible if we work together, as well as internalize the juxtaposition of the interconnectedness between these two themes. We also hope to inspire people to find the power within themselves through their own experiences and struggles and to envision a better world within our community and beyond.
When we wake up we’re given another opportunity to make the best choices for ourselves. We can begin to acknowledge and reconcile our mistakes, internalize the lessons, and move onward. It takes time, but everyday we are alive, the day offers a chance for us to strengthen our practices (rituals, prayers, meditations, etc). Not everything can be fixed, but we can reignite our self-healing practice whenever we choose. The sooner, the better; why not start the day with healing?! What are some of your morning rituals?
Download Loosid app today, Our sober Community help you to get sober and organise sober events for sober fun.
Live link
#Nithyananda #NithyanandaSatsang #KAILASA #Kailaasa #Hinduism"
*LET ME EXPLAIN THIS MESSAGE.
*LISTEN DEEPLY. INTERNALIZE. JUST BY LISTENING, YOU WILL INTERNALISE AND YOU WILL START MANIFESTING!
*SHRAVANA FROM THE RIGHT PERSON MAKES THE TRUTH WHICH IS HEARD MANANA AND NIDIDHYASANA
*RIGHT LISTENING FROM THE RIGHT PERSON, MAKES THE TRUTH SINK INSIDE YOU AND THE TRUTH MANIFESTS AS REALITY IN YOUR LIFE.
*SCIENCE OF REJUVENATION THROUGH COLLECTIVE INTEGRITY
Live link
#Nithyananda #NithyanandaSatsang #KAILASA #Kailaasa #Hinduism"
*LET ME EXPLAIN THIS MESSAGE.
*LISTEN DEEPLY. INTERNALIZE. JUST BY LISTENING, YOU WILL INTERNALISE AND YOU WILL START MANIFESTING!
*SHRAVANA FROM THE RIGHT PERSON MAKES THE TRUTH WHICH IS HEARD MANANA AND NIDIDHYASANA
*RIGHT LISTENING FROM THE RIGHT PERSON, MAKES THE TRUTH SINK INSIDE YOU AND THE TRUTH MANIFESTS AS REALITY IN YOUR LIFE.
*SCIENCE OF REJUVENATION THROUGH COLLECTIVE INTEGRITY
When you internalize this great truth that
everything is a changing dream, you will not be
able to do whatever you want to do! You will only
do whatever the Cosmos wants you to do. You
will not be able to do whatever you want, because
the moment you understand this truth, tremendous
inner healing will start happening. The struggle
or the suffering will come to an end. One glimpse:
whatever is happening is a changing dream, it is
constantly changing, your ideas are changing, your
ideas about changing are changing, your ideas
about transformation are changing, your ideas
about problems are changing...the whole thing
changes.
Download your free copy of Living Enlightenment
People have a similar instinct to animals in the wild as to the calling within themselves to go to a place while not necessarily knowing the specifics as to where. Undomesticated animals have no restrictions regarding what holds them back or in an environment in which they lack from. We as humans can often internalize the lack we found in our daily lives through the conscious action of looking for more outside of it. People tend to not know where the trail of their journey leads to or what lies ahead at the end of it, all though that doesn’t mean that these individuals can not or won’t find their happiness in their lives already. Generally speaking, there is no preparation on living or where someone’s life will go at each step. Perhaps all that human beings need is the hopefulness that can be sought in themselves in order to listen to the beckoning call of their nature with an thankful answer.
5 The Ossified Hunger
Fifth shard in The Leviathan’s Maw
Within the greater mythos of The Frozen Threshold
This is not crystal—it is calcified appetite. The Ossified Hunger reveals a shard where the Leviathan’s devouring force has curled into form, fossilized mid-consumption. The jagged, layered anatomy is not inert—it is coiled intent, a micro-landscape shaped by the passage of mythic hunger through reality’s membrane.
The curling structure does not reach—it waits, poised in a state of suspended devouring. This is not motion—it is ritual posture, the Leviathan’s appetite made visible in anatomical stillness. The shard hums with the tension of what it once consumed—and what it still remembers.
Psychologically, this image speaks to the terror of internalized hunger—the moment when the devouring force is no longer external, but embedded, ossified within the psyche. The viewer does not witness destruction—they witness preserved consumption, a hunger that has become architecture.
This is not fossil—it is function, and it remains ready.
Andrew Wyeth - 1917 - 2009
______________________________________________
The watercolors in this show reflect Andrew Wyeth’s career-long project of transforming his subjects into forceful and compelling meditations on how we conceptualize what we see. The visual power of each painting relies on simple contrasts between dark and light. Much like ancient Chinese calligraphy or modern abstract expressionist techniques, Wyeth’s intuitive, efficient brushstrokes internalize the dynamic energy of gesture as they simultaneously define and anchor each composition’s overall structural framework. The viewer’s eye sees only what is necessary to construct meaning from experience.
Inspired as a teenager by the watercolors of Winslow Homer, Wyeth struggled to replicate the master’s rendering of atmospheric effects. In 1937, only one year after painting Tending the Net, Wyeth enjoyed commercial success with a sold-out exhibition of watercolors in New York City. By that time he had abandoned Homer’s tidy realism for a more expressive, color-saturated style. The work exhibited here exemplifies the maturing artist’s restless experimentation with paint application and texture that ultimately achieved an emotional status for the most mundane objects and environments.
Andrew Wyeth - 1917 - 2009
______________________________________________
The watercolors in this show reflect Andrew Wyeth’s career-long project of transforming his subjects into forceful and compelling meditations on how we conceptualize what we see. The visual power of each painting relies on simple contrasts between dark and light. Much like ancient Chinese calligraphy or modern abstract expressionist techniques, Wyeth’s intuitive, efficient brushstrokes internalize the dynamic energy of gesture as they simultaneously define and anchor each composition’s overall structural framework. The viewer’s eye sees only what is necessary to construct meaning from experience.
Inspired as a teenager by the watercolors of Winslow Homer, Wyeth struggled to replicate the master’s rendering of atmospheric effects. In 1937, only one year after painting Tending the Net, Wyeth enjoyed commercial success with a sold-out exhibition of watercolors in New York City. By that time he had abandoned Homer’s tidy realism for a more expressive, color-saturated style. The work exhibited here exemplifies the maturing artist’s restless experimentation with paint application and texture that ultimately achieved an emotional status for the most mundane objects and environments.
Andrew Wyeth - 1917 - 2009
______________________________________________
The watercolors in this show reflect Andrew Wyeth’s career-long project of transforming his subjects into forceful and compelling meditations on how we conceptualize what we see. The visual power of each painting relies on simple contrasts between dark and light. Much like ancient Chinese calligraphy or modern abstract expressionist techniques, Wyeth’s intuitive, efficient brushstrokes internalize the dynamic energy of gesture as they simultaneously define and anchor each composition’s overall structural framework. The viewer’s eye sees only what is necessary to construct meaning from experience.
Inspired as a teenager by the watercolors of Winslow Homer, Wyeth struggled to replicate the master’s rendering of atmospheric effects. In 1937, only one year after painting Tending the Net, Wyeth enjoyed commercial success with a sold-out exhibition of watercolors in New York City. By that time he had abandoned Homer’s tidy realism for a more expressive, color-saturated style. The work exhibited here exemplifies the maturing artist’s restless experimentation with paint application and texture that ultimately achieved an emotional status for the most mundane objects and environments.
Andrew Wyeth - 1917 - 2009
The Letter - 1979
______________________________________________
The watercolors in this show reflect Andrew Wyeth’s career-long project of transforming his subjects into forceful and compelling meditations on how we conceptualize what we see. The visual power of each painting relies on simple contrasts between dark and light. Much like ancient Chinese calligraphy or modern abstract expressionist techniques, Wyeth’s intuitive, efficient brushstrokes internalize the dynamic energy of gesture as they simultaneously define and anchor each composition’s overall structural framework. The viewer’s eye sees only what is necessary to construct meaning from experience.
Inspired as a teenager by the watercolors of Winslow Homer, Wyeth struggled to replicate the master’s rendering of atmospheric effects. In 1937, only one year after painting Tending the Net, Wyeth enjoyed commercial success with a sold-out exhibition of watercolors in New York City. By that time he had abandoned Homer’s tidy realism for a more expressive, color-saturated style. The work exhibited here exemplifies the maturing artist’s restless experimentation with paint application and texture that ultimately achieved an emotional status for the most mundane objects and environments.
Product Description
Ripertamab is a monoclonal biologic of high purity, supplied as a lyophilized powder to ensure long-term stability and bioactivity. It selectively targets cell-surface receptors, modulating downstream signaling cascades to facilitate in-depth mechanistic studies. Its applications encompass receptor-ligand binding analysis, functional cellular assays, structural characterization, and preclinical translational models.
Molecular Background and Scientific Relevance
Receptor-targeted research is fundamental in understanding cellular physiology, signaling, and pathological mechanisms. Ripertamab was developed to provide a high-purity, stable, and reproducible biologic tool for receptor-focused investigations. By selectively binding to its target receptor, it modulates activation, inhibition, or internalization, allowing researchers to dissect complex receptor-mediated pathways with high precision. The biologic is widely utilized in oncology, immunology, and neurobiology research, supporting studies on proliferation, apoptosis, differentiation, migration, and receptor-ligand interactions.
Applications in Receptor Research
Ripertamab enables a wide array of experimental applications:
Receptor-Ligand Binding Studies: Quantitative binding assays, competitive inhibition, and receptor occupancy determination provide insights into receptor dynamics.
Product Description
Efbemalenograstim Alfa Solution (CAS 2200269‑79‑8) is a high-purity, recombinant, long-acting G-CSF fusion protein designed exclusively for laboratory and mechanistic research. Structurally, it consists of a dimer of human G-CSF molecules linked to a human IgG2 Fc fragment, forming a stable dimeric configuration that prolongs protein half-life through Fc-mediated recycling. This extended stability allows sustained receptor engagement, enabling precise studies of granulopoiesis, signal transduction, and progenitor cell proliferation under controlled experimental conditions.
In vitro and ex vivo models benefit from the prolonged G-CSF receptor activation provided by Efbemalenograstim Alfa, as it supports extended JAK/STAT signaling, particularly STAT3 and STAT5 phosphorylation. Researchers can monitor downstream transcriptional responses, anti-apoptotic gene expression, and differentiation kinetics in primary hematopoietic progenitor cells. The sterile solution format eliminates variability associated with lyophilized reconstitution, ensuring reproducible concentrations and reliable mechanistic observations in cell culture systems.
The design of Efbemalenograstim Alfa allows investigators to model long-term granulopoiesis, examine receptor internalization, and study feedback regulation of the G-CSF signaling pathway.
Product Description
Exendin 4, Biotin Labeled is a chemically modified analog of Exendin 4 (HY-13443), a potent and selective glucagon-like peptide-1 receptor (GLP-1R) agonist. Derived from the natural exendin sequence found in the saliva of the Gila monster (Heloderma suspectum), this biotinylated version retains full receptor activity while incorporating a biotin moiety that allows easy conjugation to streptavidin-based detection systems.
This modification expands its versatility for use in receptor binding assays, ligand-receptor mapping, fluorescence imaging, and high-throughput screening (HTS) of GLP-1–targeted compounds. Researchers often utilize Exendin 4, Biotin Labeled to visualize and quantify GLP-1 receptor expression, study receptor internalization pathways, and monitor ligand-induced signaling events.
As a long-acting GLP-1 receptor agonist, Exendin 4 mimics the biological actions of endogenous GLP-1 but exhibits enhanced stability and prolonged receptor activation, due to its resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). It plays a crucial role in the regulation of glucose metabolism, insulin secretion, appetite control, and β-cell survival.
The biotin labeling does not significantly alter its binding affinity or activity, allowing researchers to use it as a functional probe in receptor-ligand studies or in pull-down assays to isolate GLP-1R complexes.
I can’t pinpoint the exact moment I first stepped into Our Place, but I’ve come to believe it was nothing short of a divine blessing. My journey here has been transformative, not just for me, but for everyone I’ve had the privilege to connect with, particularly my fellow veterans. From 1980 to 1984, I served in the U.S. Army, a period that shaped me in profound ways. It was during those years that I internalized the core values of loyalty, teamwork, and service—values that have become the bedrock of my life and my recovery. These principles inspired me to create the Veterans’ Support Group at Our Place, a space where men and women who’ve served can come together to heal, grow, and support one another.
The Veterans’ Support Group is more than just a gathering; it’s a sanctuary of shared understanding and mutual respect. When we sit together, we bring with us the unspoken bond of comradeship forged in service. Our stories, though often marked by pain and struggle, are also filled with resilience and hope. In this space, we lean on one another, drawing strength from our collective experiences. We know what it means to work as a team, to have each other’s backs, and to ensure that no one is left behind in the journey of recovery.
On my path, I’ve discovered something extraordinary: the power of connection, a bond that transcends words. The friendships I’ve formed here are rooted in a deep sense of camaraderie and commitment to healing. Together, we’ve created an environment where trust, support, and encouragement flourish. This is the essence of Our Place—a community built on cooperation, service, and the unwavering belief that together, we can heal.
rp @iamrachelricketts: When we commit ourselves to authentic anti-racism it’s an all-hands on deck experience.⠀⠀⠀⠀⠀⠀⠀⠀⠀
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It requires our mental, emotional, physical and spiritual buy in. We appreciate that so long as white supremacy reigns supreme there are lives and livelihoods are on the line, so it is our obligation to give this work our ALL. ⠀⠀⠀⠀⠀⠀⠀⠀⠀
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We acknowledge the ways in which we have perpetuated white supremacy - through racism or internalized oppression - and commit ourselves to the deep inner work required to face our shadows and heal our hearts so we can contribute to healing the collective divide.⠀⠀⠀⠀⠀⠀⠀⠀⠀
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This work is also reflected in who we surround ourselves with (and equally who we do not). If your closest friends and family aren’t doing this work then you aren’t really doing yours. Your inner circle is a reflection of you and what you value - what is yours telling you?⠀⠀⠀⠀⠀⠀⠀⠀⠀
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When we are dedicated to fighting racial injustice we simply will not stand for those who continue to choose complacency and perpetuating harm.⠀⠀⠀⠀⠀⠀⠀⠀⠀
We need to bring people into this movement, without question. And sometimes engaging in such a discussion is precisely what is required, especially for the white folx cuz y’all are doing the most harm (collect your people)! But it is equally important to lead by example and make it clear that racism and white supremacist behaviors will not be tolerated. Boundaries need to be set and stuck to. They needn’t be mean or vindictive, but sometimes we can make the loudest point by being clear about what is unacceptable + being unwilling to engage with such behavior.⠀⠀⠀⠀⠀⠀⠀⠀⠀
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When you are authentically engage in anti-racism you will likely lose friends + family members. Your viewpoint goes against the status quo + demeans those with power and privilege. It can be a lonely place. You will give ish up. Without question. But oh what you will gain! Healing, connection, being on the right side of history + so much more. How have you freed yourself from the things you are not? Have you disassociated and disconnected yourself from the things and people not contributing to the right causes or contributing negatively? - #diversityandinclusion #nashvilleteacher #antiracism #highereducation #blackhistory #ally #teachershare #blackintheivory #whitefragility #changingthenarrative #ushistory #socialstudies #historyteacher #teacherproblems
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GSCASH... for a new beginning.
Friends, .
Let me introduce myself: my name is Devi Dayal Gautam a student, contesting.
not for the post of students representative for GSCASH but for the crusade that Ipropose to embark upon for gender justice for both women as well as men..
I find the issue of 'sensitisation' the most difficult and daunting all on the path to.
"sensitization", in this context, to me means culminating and inculcating in the society gender equality and gender justice. I find the issue most sensitive shorn of rhetoric.
such mutual aspects for each others' personal space that any encroachment cease not.
as a matter of coercion of law or any other form of compulsion but as a matter of.
internalization of the sensitivity to each others sense of self-respect and individualfreedom..
\ Internalisation of sensitization with regard to any crime from that of culpable.
acknowledge that crime rates (of any form) do not depend upon be level of stringency homicide to uncalled for sexual advances is most important as it has been universally.
of the laws but that of enforcement of the laws. The most recent example in this.
regard has been the debate upon capital punishment. In Canada the Crime ratewentbeefed up. .
down when capital punishment was abolished and the enforcement of punihment was.
Thus I propose to concentrate primarily upon the internalization of the education.
regarding mutual respect for each other's personal freedom and space and beef up the.
mechanism of punishment with respect to cases of sexual harassment.Questions have been there regarding impartiality of this body. I think this has.
.
been due to the failure of the past elected representatives that they were not able to.
infuse confidence in the general populace. I wish to change this by working for the.
cause in such ways that do not inspire any kinds of doubts and ward off any kinds of.
doubts regarding the body by involving the students in general in the entire process of.
sensitization. In nut and sheJI I wish to turn the exclusivist nature of GSCASH into a.
body not in the administration of the university but in the minds of the students. .
more transparent and open organization for this, I think, will further institutionalize this.
The body has been facing teething infrastructural problems which need urgent.
attention. Further I .
wish to integrate various other All.
organizations geared up to this issue to get .
India and Internationallogistical and Ideological support andfurther break the isolation of this much needed body..
I further propose to involve the studert community in deciding upon the.
instruments for furthering the sensitization agenda. Let the whole student community.
harassment on the campus. .
and not just this body to stand armin arm unitedly against any form of sexual .
Expecting Your Vote & Support .
Sd/-.
Devi Dayal Gautam.
for GSCASH Student Representative .
.
Ignore the critics!
That's something I will continue to do into 2025, and as we barrel into a year that promises to be unlike many others, it's something you should consider too.
Let me share something I've learned about dealing with criticism throughout my career - take in the good criticism, and ignore the other stuff! It's fascinating how good criticism - honest insight that can hide valuable wisdom, even when it doesn't feel that way - can help to move you forward. At the same time, it's stunning how easily it is for us to take in and internalize the hateful, agenda-oriented, anger-driven barbs that you might get along the way - and which cause us real damage.
Always keep in mind that you are always dealing with two types of critics. Some will share harsh feedback that contains insight that can help us grow. At the same time, others will share criticism that should be ignored, because it's agenda-oriented, or is driven by fear, jealousy, or other emotions. The key is learning the art of knowing which is which, and that's the key: you need to be selective about which criticism you take to heart.
Over the years, I've watched too many talented people get derailed by letting others' opinions overshadow their vision, ideas, and beliefs. I also know that I've often taken too much criticism to heart when I shouldn't have - as someone who spends time on a stage as a key part of their work, I've often had to learn the hard way how to take in what matters and ignore the rest!
Here's the key thing that I've learned and what I've noticed about innovators and change-makers, don't take it to heart. Often they are criticizing change, and not you. That's because if you're doing something truly groundbreaking, criticism is almost inevitable. Why? Because you're challenging the status quo, and that makes some people uncomfortable. Often, they won't know how to react and will lash out because you represent the thing they fear the most - change. But here's my advice: don't waste energy arguing with them - often, there is absolutely no upside. Accept their fear for who they are, and move on.
Another key way to manage criticism is to avoid the critics who offer useless critical insight! One of the most important lessons I've learned is about the people you surround yourself with. I cannot stress this enough – find those who lift you, rather than those who will drag you down. Spend time with those who see possibilities where others see problems. These are the people who will help you maintain that crucial positive mindset that drives creativity and innovation forward. You'll also find a huge difference between the constructive criticism they might offer vs. the destructive criticism of others.
This has become particularly important in the often toxic world which has become a core part of some social networks. Voyage into the sludge. that is Twitter or X or whatever it's called with a positive message, and you will soon be subjected to the scorn and criticism of those who seem to take joy in offering up a regular stream of hateful criticism. Most of it is useless in terms of being something to build upon. There's no upside - none - so why bother?
You should also put the issue of criticism into the light of science. Studies on the idea of defensive processing" found that people who maintain a strong sense of self-worth are better able to process criticism constructively, rather than needing to ignore it completely. That's because they excel at the idea of how to use criticism to their advantage. Think of criticism this way - your self-identity is a skyscraper. Each floor represents a different aspect of who you are - your professional abilities, your relationships, and your creative talents.
What the research found is ts that when you keep the whole building strong and well-maintained, a crack in one floor doesn't threaten the entire structure. You become better equipped to repair that crack because you're not afraid the whole building will collapse. Overall, the study found that we can condition ourselves to easily manage criticism and turn it into a strength.
The core conclusion was that when people took a moment to reflect on what truly mattered to them - their deep personal values, their meaningful relationships, their core strengths - they didn't just survive criticism; they thrived on it!
Remember, your unique perspective and talents are exactly what we need in this rapidly changing world. Don't let anyone's criticism dim that light.
I've seen too many brilliant ideas never reach their potential because someone listened to the wrong voices.
#Criticism #Growth #Resilience #Success #Confidence #Innovation #Authenticity #Leadership #Strength #Vision
Original post: jimcarroll.com/2024/12/daily-inspiration-25-things-for-20...
I learned long ago that the future just isn't a place we go - it's a direction we should always be focused on! It's not a place that we arrive at - it's a series of events that we strive to achieve to get to the opportunities it presents. It's not just a place that we arrive at and spend our time - it's an elusive target that is always out there, begging us to participate in what it offers.
That's why you need to stop thinking about the future as just a destination - you need to think about it as a direction to take! It's a lighthouse beacon screaming out to you from the fog, providing you desperately needed insight on where you need to go to avoid the hazards of disruption, the challenges of the fast currents of relentless changes, and the relentless swells of ongoing volatility that it tosses your way.
Follow the guidance it is offering you.
I can't emphasize enough that shaping your future is more about adopting a particular way of thinking rather than just reaching a specific goal. This way of thinking involves several key elements that are critical to what you do: it's a directional mindset that has several key characteristics.
- a forward orientation: The most important thing you can do is to make sure you are always focusing on what's ahead instead of dwelling on the past. This means understanding and anticipating future trends, proactively adapting to change, and constantly seeking new knowledge and skills - and starting to act on that forward orientation rather than acting on today and yesterday.
- a mindset of continuous reinvention: A directional mindset acknowledges that the future is not a static endpoint but a journey of continuous adaptation, a story that involves relentless evolution. You must be prepared to reinvent yourself, your skills, and even your business model to stay relevant and thrive in our rapidly changing world - and do this on a continuous basis as a part of the voyage.
an openness to opportunity: You can't keep clinging to today or looking back with fondness at yesterday. A directional mindset is characterized by
- a willingness to embrace new possibilities, challenge assumptions, and explore uncharted territories - and do that nonstop. It's about seeing the future not as a threat, but as a landscape full of potential opportunities waiting to be discovered and shaped, and acting on those opportunities NOW.
- continuous proactive action: A directional mindset is not passive; it's a mindset that is all about taking action, making decisions, and moving forward despite uncertainty. It's about understanding that the future is not something that simply happens to you; it's something you actively create through your choices and actions. The steps involved are making those choices instead of avoiding them.
- a core of mental flexibility: A directional mindset recognizes that the path to the future is rarely straightforward. It requires agility, the ability to adjust course, and a willingness to learn from setbacks. You need to be comfortable with ambiguity embrace the fact that the future is full of twists and turns - and move yourself accordingly.
By cultivating a directional mindset - one of action, not stagnation - you become more than just a passive passenger on the journey to the future. You become an active participant, a navigator, and a creator, shaping your destiny before others shape it for you.
Over the years, I've seen this mindset in some of the more successful Fortune 500 executives and organizations I've spent time with worldwide. Successful future-oriented leaders and companies share a common trait - they understand that thriving tomorrow requires more than just planning for a fixed endpoint - they are focused equally on the voyage that is involved in getting there.
When I spend time with major manufacturing clients, I see many who are fixated on "the way we've always done things" who then get blindsided by disruption. The winners? I see that they're busy scanning the horizon, tracking emerging technologies and trends, and positioning themselves to capitalize on what's next. They invest a lot of time in building the foundation for the voyage, knowing that it involves a lot of specific steps, rather than just some grandiose one-time project.
I've also seen it with a few healthcare organizations. One hospital network I advised completely reimagined its care delivery model around virtual health solutions long before COVID hit. When the pandemic arrived, they were ready while others scrambled - because they knew that the future was telling that the virtualization of healthcare was a clear destination and that it would involve a lot of investment to get there.
The most innovative organizations I work with cultivate what I call "opportunity radar" - they're constantly sensing and responding to weak signals of change. A retail client detected early signs of the subscription economy trend and launched a wildly successful subscription box service while competitors watched from the sidelines. Again, when the volatility of the pandemic hit, they were better positioned than their competitors.
A major energy company I spent time with didn't just talk about renewable energy disruption - they committed billions to transforming their infrastructure and talent base. They challenged their business model because they could see that we are shifting to a world in which local energy microgrids are becoming a key part of the overall energy grid. They did everything they could to shift their thinking to this reality and act upon the many steps it would take to get there - so much so that this architecture became their mindset, not just a destination.
Notice a trend? All of these organizations had a common leadership mindset - you can't just think about the future, you have to act on it as a series of steps to take. The companies that own tomorrow understand that the path forward isn't linear - it's a routine. I tell my clients: develop your change muscles. Build your ability to pivot, experiment, and course-correct as the landscape shifts. The future belongs to the agile.
The organizations that internalize this directional mindset - that watch the navigational beacon that is tomorrow - don't just survive in a world of exponential change - they thrive on it.
They become the disruptors rather than the disrupted.
The question is: are you cultivating the directional mindset needed to shape it, rather than be shaped by it?
#Future #Direction #Innovation #Change #Leadership #Mindset #Opportunity #Disruption #Transformation #Vision
Original post: jimcarroll.com/2024/12/daily-inspiration-25-things-for-20...