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Rotavirus-Rotaviruses, representing the primary pathogens responsible for acute dehydrating diarrhea in children under the age of 3, are non-enveloped, double-stranded, RNA viruses belonging to the Reoviridae family. The mature, infectious, rotavirus particle, 100 nm in diameter, is an icosahedral, triple-layered particle (TLP) containing a genome formed by 11 segments of double-stranded RNA that code for 12 proteins, including six structural (VP1, VP2, VP3, VP4, VP6, and VP7) and six non-structural (NSP1-NSP6) proteins.