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The most common theory for the toponymy of Brussels is that it derives from the Old Dutch Broeksel or other spelling variants, which means marsh (broek) and home (sel) or "home in the marsh". The origin of the settlement that was to become Brussels lies in Saint Gaugericus' construction of a chapel on an island in the river Senne around 580. Saint Vindicianus, the bishop of Cambrai made the first recorded reference to the place "Brosella" in 695 when it was still a hamlet. The official founding of Brussels is usually situated around 979, when Duke Charles of Lower Lotharingia transferred the relics of Saint Gudula from Moorsel to the Saint Gaugericus chapel. Charles would construct the first permanent fortification in the city, doing so on that same island.
[From the Wiki entry: en.wikipedia.org/wiki/Brussels ]