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Are you considering whether or not to get tested for MTHFR? If you haven’t already, check out how getting tested for MTHFR changed the life of our founder, Jamie Horn. Read more >>
If you are ready to get tested, but are wondering what your options are, this post is for you!
There are three good options for getting tested for MTHFR. We’re here to help you navigate the pros and cons of each so that you can find out what your specific MTHFR mutation status actually is. Then, check out our great resources about what your unique status means for your health:
Treating MTHFR >>
Dosage >>
Choosing the Right Methylfolate Products >>
Methyl-Life’s preferred MTHFR testing options:
A genetic blood test your doctor can order
Holistic Heal’s DNA Panel for the Methylation Pathway
23andme’s Comprehensive DNA Panel
A genetic test your doctor can order
If you want an MTHFR mutation test, the most affordable approach is to have your doctor run the test for just the 677 & 1298 MTHFR mutations. Insurance companies are getting much more willing to cover this genetic test as more and more research becomes available. And more research is becoming available specifically about the 677 & 1298 SNPs (single nucleotide polymorphisms), which are two MTHFR SNPs that are linked to many different studies about cardiovascular disease, miscarriage, depression, neuropathy, dementia, Alzheimer’s, and more. Just get on pubmed.com and search for MTHFR. There’s a lot of clinical research that shows up!
The upside: it’s usually free or just the cost of your time, gas, and a copay ($10-40).
The downside: you only get a very small amount of information for this outlay (MTHFR 677 & 1298 status). Truthfully, there’s not a lot you can do with this result by itself. It’s not enough information to build a solid program for your individual health, since you do not know anything about the genes and enzymatic exchanges that happen before or after it. You won’t know what your status is for any of the other 40+ less-well-known MTHFR SNPs. You also don’t get to know what your status is for any of the other genetic SNPs that are important for what happens before and after the MTHFR enzymatic conversions along the methylation cycle pathway (i.e., COMT, MTR, MTRR, VDR, CBS, etc). And finally, you won’t get any information on genetic SNPs affecting other biopathways in your body. There are literally millions!
Holistic Heal’s DNA Panel for the Methylation Pathway
Another approach might be that you contact Holistic Heal (an organization we’re familiar and comfortable with) and have them run a full panel methylation test for you. You pay for a kit that gets sent to you, and then you do the test at home. It consists of doing a finger prick, which requires you to smear some blood into 3 small circles. This test, developed by Dr. Amy Yasko, focuses specifically on 30 key gene SNPs that are on the methylation pathway. These are genes that work together in the more complicated cases for those who have things like Autism and Chronic Fatigue. Dr. Yasko’s test is more comprehensive than the genetic test discussed above. It takes about 12 weeks to get your results back, but when you do, you will get a specialized protocol detailing what vitamin forms are the best for your body’s health based on each of the gene defects that is uncovered in the test. She also specializes in treating Autism, so if you want a detailed list of supplements to take, a forum & online support system, and/or you have Autism in your family, this is our recommendation!
The upside: you will get your MTHFR mutation status (677 & 1298, plus an additional MTHFR SNP), along with the 27 other most important SNPs around it in the methylation cycle. You get access to a mature support forum from someone considered the “nutrigenomic grandmother” in the field. If you have Autism or Chronic Fatigue, you might gain particular benefit, since these are Dr. Yasko’s specialties.
The downside: it’s a bit pricey at $500 per test. But we think it’s worth it, considering that it includes forum support & comes with the full breadth of Dr. Yasko’s learning and practice in this field.
23andme’s Comprehensive DNA Panel
Another great option is to get your genetics test done through 23andme.com, which is a wonderful non-profit organization. You pay $99, and the company sends you a test kit which consists of a vial for saliva collection (you just spit into it). Once you fill it, you send it back to them and wait for your results. The main thing you get with 23andme results is a raw data file that provides results for hundreds of thousands of gene SNPs. You can download these results and do whatever you want with them! However, since it’s not very readable on its own, the best thing to do with it is to pay a partner company to “transform it” for you. For somewhere between $20-40, these partner companies will give you a readable report. Typically, green is used to show any gene that is considered “normal” or not mutated, yellow for any gene that is considered to be a “single” mutation (one mutation from either the biological mother or father, but not both), and red for any gene that is a “double” mutation (or one mutation from both the biological mother and father). We’ve included some of these 23andme data transformation companies below.
The upside:it’s incredibly affordable and provides you data for a huge number of genes in your body across many different biopathway systems.
The downside:if you wait, it’s likely that the FDA will continue to reduce the number of genes that 23andme can test and provide results for. (Yes, this has already been done. Current versions of the test show far fewer gene results than earlier versions.) Another downside is that there is no medical authority available through 23andme to interpret the results with clear, experienced guidance for how to manage the them. You have to do a lot of the research on the gene results yourself, or find and work with forums who have this information.
23andme Raw Data Transformers (creating a human-readable results report)
MTHFR Support
Doctor’s Data
Genetic Genie
Livewello
The post MTHFR Testing Options appeared first on Methyl-Life.
gorilla at the zoo.
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Maximum likelihood phylogeny of known Papaver S-alleles and putative S-alleles from other taxa.
The Papaver S-alleles (alleles PrsS1, PrsS3 PrsS8 and PnSn1 in bold) identified by [5] and [6] form highly divergent lineages that include recently identified sequences from P. mcconnellii but show no close associations with any non-Papaver sequences. All sequences from P. californicus form a distinct monophyletic clade while sequences from A. munita and R. coulteri show some poorly supported shared polymorphism. P. californicus linked sequences S2d and S2e from parental plant 2 are found in separate sub-clades as are co-inherited sequences S3a and S3b from parent 3 (italics). Sequences used in crosses for A. munita and P. californicus are indicated as text.
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Anne et Patrick Poirier développent une œuvre polymorphe dans laquelle la photographie occupe, dès leurs débuts en 1967, une place aussi centrale que méconnue, au même titre que la sculpture ou l’installation. Au fil des ans et de leurs expérimentations, ils n’ont cessé de développer un corpus d’œuvres, explorant sans a priori et sans limite les possibilités du médium photographique. Cette exposition, qui réunit près de 200 tirages, en propose la première rétrospective.
A species which is variable in flower colour and leaf spotting. Cambourne seems to have almost the full range of colour combinations.
–carretón común, mancaperros–
= M. hispida Gaertn.
= M. lappacea Desr.
= M. polymorpha subsp. polycarpa (Willd.) Romero Zarco
Vegetación arvense, ruderal y viaria, 0–1500 m.a. Subcosmopolita. Presente en todo el territorio.
This look is for all of the iconic Vampire Horror Movies so I did a Sexy Vampire.
Products Used:
Polymorph Plastic for the teeth
General beauty makeup
Contacts are photoshopped
–carretón común, mancaperros–
= M. hispida Gaertn.
= M. lappacea Desr.
= M. polymorpha subsp. polycarpa (Willd.) Romero Zarco
Vegetación arvense, ruderal y viaria, 0–1500 m.a. Subcosmopolita. Presente en todo el territorio.
Can anyone confirm id? On cuckoo flower Cardamine pratensis N Scotland. Looking at the NBN map this find appears to be new for the VC of Caithness (& quite remote from the nearest N Scotland record shown as in the Bettyhill area). It seems colour polymorphism has been studied in this beetle (The origin of extensive colour polymorphism in Plateumaris sericea (Chrysomelidae, Coleoptera). Kurachi M1, Takaku Y, Komiya Y, Hariyama
The abstract from that study states :
"Evidence is presented to demonstrate that colour polymorphism in a beetle arises from structural colours produced by a five-layered reflector in the elytron. The colour of leaf beetles, Plateumaris sericea, ranges across the visible spectrum from blackish-blue to red. The elytra have two distinct layers: epicuticle and exocuticle. Morphological observations reveal that the multilayer structure within the exocuticle differs little among the different colour morphs but the layers within the epicuticle have characteristic thicknesses corresponding to the observed colour. The reflectors, consisting of five layers within the epicuticle, are responsible for all the different colours observed in P. sericea, as shown by theoretical analyses for a multilayer stack, and by showing that removal of the elytral surface, including epicuticle, results in the disappearance of the iridesce colour. " The larvae are considered to feed on the roots of aquatic plants while the adults seem to feed on pollen. It is a widespread and common species but maybe less so in Caithness than some other areas unless it is just under recorded.
Among the species of diurnal herons (Ardeinae) showing light-dark colour polymorphism in plumage, colour phase is age-related in one species, closely associated with geography in three species, and found in most populations in three closely related species of reef herons. In Pacific Reef Herons Egretta sacra white-phased birds sought prey by a flight, land, and freeze hunting style in breaking surf, while dark birds pursued prey by actively walking or running on reef flats. On Mangaia, in the southern Cook Islands, more white-phased birds used the windward side of the island and more dark-phased birds used the lee side. On Rarotonga, 204 km from Mangaia, reef herons foraged almost exclusively in shaded streams and no entirely white-phased bird was encountered. These results provide the first evidence of differences in hunting techniques associated with colour morph and only the second observation of differences in habitat use by white- and dark-phased herons at single localities. As such they support Murton's (1971) idea that colour polymorphism serves herons in their role as predators.
Arduino and custom grip made from Polymorph. 5 buttons will form a text-entry device similar to the Microwriter or Cykey. Just need some help with the code!!
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A mineral is a naturally-occurring, solid, inorganic, crystalline substance having a fairly definite chemical composition and having fairly definite physical properties. At its simplest, a mineral is a naturally-occurring solid chemical. Currently, there are over 6100 named and described minerals - about 200 of them are common and about 20 of them are very common. Mineral classification is based on anion chemistry. Major categories of minerals are: elements, sulfides, oxides, halides, carbonates, sulfates, phosphates, and silicates.
The carbonate minerals all contain one or more carbonate (CO3-2) anions.
Aragonite has the same chemistry as calcite - it is calcium carbonate (CaCO3). Why is it a different mineral? Aragonite has a different molecular structure - the atoms are packed differently. Different minerals having the same chemical formula are called polymorphs (another good example is graphite & diamond - both C).
The difference in atomic-level packing between calcite and aragonite can be seen at the level of mineral hand samples. Aragonite forms crystals in the orthorhombic class. Many aragonite crystals are acicular (needle-like). Many aragonites form pseudohexagonal crystals, the result of 6 orthorhombic prisms growing parallel to each other. The specimen seen here is a top view of a cyclic-twinned, pseudohexagonal aragonite mass.
Aragonite is slightly harder than calcite, at H=3.5 to 4, occurs in many colors, and easily bubbles in acid. Aragonite is a little bit heavier than calcite, due to closer packing of atoms.
Most modern seashells & coral skeletons are composed of the aragonite. Whitish-colored lime sand beaches in the world are aragonitic. Occasionally, "whitings" are seen in shallow, warm ocean environments. Whitings (cloudy, milky seawater) turn out to be loaded with tiny hair-like needles of aragonite.
In the rock record, aragonitic or aragonite-rich sediments convert to calcite over time. Cenozoic-aged carbonate sedimentary rocks are often aragonitic. Mesozoic- and Paleozoic-aged carbonates are almost always calcitic. Many ancient fossils have had their aragonitic shells dissolved away. Ancient shells that were originally calcitic are often still well preserved.
Locality: unrecorded / undisclosed, but possibly from Spain
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Photo gallery of aragonite: