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In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
Salk #researchers and #collaborators have achieved critical insight into the size of #neural connections, putting the #memory capacity of the #brain far higher than common estimates. The new work also answers a longstanding question as to how the brain is so energy efficient and could help #engineers build #computers that are incredibly powerful but also #conserve #energy .
"This is a real bombshell in the field of #neuroscience," says Terry Sejnowski, Salk professor and co-senior author of the paper, which was published in eLife. "We discovered the key to unlocking the design principle for how #hippocampal #neurons function with low energy but high computation power. Our new measurements of the brain's memory capacity increase conservative estimates by a factor of 10 to at least a #petabyte, in the same ballpark as the #World #Wide #Web ."
Our memories and thoughts are the result of patterns of #electrical and #chemical activity in the brain. A key part of the activity happens when branches of neurons, much like electrical wire, interact at certain junctions, known as synapses. An output 'wire' (an axon) from one neuron connects to an input 'wire' (a dendrite) of a second neuron. Signals travel across the synapse as chemicals called neurotransmitters to tell the receiving neuron whether to convey an electrical signal to other neurons. Each neuron can have thousands of these synapses with thousands of other neurons.
Testing Ankyrin-G (which goes to axon initial segment, pseudocolored to blue) with one of my GFP constructs (the green is transfection here) and Hoechst (pseudocolored to red, highlighting cell nuclei)
Leica DMRE 40x
"Dixie is not from the south as her name might suggest. She is comfortable around strangers loves a good game of Candy Land. Her interests include hopping frolicking and planting herbs. She likes to put almost anything in her mouth...please be careful. Dixie is another mischeivious neuron that is a manifestation of my own rebellious neurons that cause a movement disorder.
(1)
Connectome
In their words:
"A connectome is a synapse-resolution mapping of connections between
all neurons in a model organism's brain. In other words, a
synapse-resolution circuit diagram of the brain. Current approaches to
mapping the connectomes of model organisms employ serial block face
scanning electron microscopy (SBF-SEM) and transmission electron
microscopy (TEM). The only connectome that has been mapped out to date
has been from the flatworm, C. elegans, which has only around 300
neurons."
(2)
ConnectomeViewer
In their words:
"The field of Connectomics research benefits from recent advances in
structural neuroimaging technologies on all spatial scales. The need
for software tools to visualize and analyse the emerging data is
urgent. ... The Connectome Viewer application was developed to meet
the needs of basic and clinical neuroscientists, as well as complex
network scientists, providing an integrative, extensible platform to
visualize and analyze Connectomics data.With the Connectome File
Format, interlinking different datatypes such as networks, surface
data, and volumetric data is easy and might provide new ways of
analyzing and interacting with data."
In addition to the viewer, this site also provides quite a variety of
that can be used to test different features and functions.
(3)
Human Connectome Project
In their words:
"The HCP will map the human connectome as accurately as possible in a
large number of normal adults and will make this data freely available
to the scientific community using a powerful, user-friendly
informatics platform."
"Successful charting of the human connectome in normal adults will be
enormously informative. Even more importantly, it will pave the way
for studies that reveal how brain circuitry changes during development
and aging and how it differs in numerous neurological and psychiatric
disorders. In short, it will transform our understanding of the human
brain in health and disease."
(4)
BrainMaps
In their words:
"Brain atlases have traditionally been one resolution and
non-interactive. The next-generation brain atlas is multiresolution,
highly interactive, and fully integrated with the latest research
literature. This is BrainMaps.org, a complete online brain atlas
founded on the principle that a brain atlas is a dynamic, interactive,
multiresolution research and didactic tool that facilitates brain
exploration and knowledge discovery."
As if that isn't enough, BrainMaps also has an API for
developers and and open source /
OpenGL-based 3D
viewer!
(5)
BrainMeta
In their words:
"BrainMeta was established for the purpose of accelerating the
development of neuroscience through web-based initiatives, which
include the development, implementation and support of a wide range of
neuroinformatics tools, services, and databases."
(6)
Allen Institute for Brain Science: Brain Atlas
In their words:
"A growing collection of online public resources integrating extensive
gene expression and neuroanatomical data, complete with a novel suite
of search and viewing tools."
(7)
Brain Museum: Comparative Mammalian Brain Collections
www.brainmuseum.org/index.html
In their words:
"This web site provides browsers with images and information from one
of the world's largest collection of well-preserved, sectioned and
stained brains of mammals. Viewers can see and download photographs of
brains of over 100 different species of mammals (including humans)
representing over 20 Mammalian Orders."
(8)
MSU: Brain Biodiversity Bank
www.msu.edu/~brains/index.html
In their words:
"The Brain Biodiversity Bank refers to the repository of images of and
information about brain specimens contained in the collections
associated with the National Museum of Health and Medicine at the
Armed Forces Institute of Pathology in Washington, DC. These
collections include, besides the Michigan State University Collection,
the Welker Collection from the University of Wisconsin, the
Yakovlev-Haleem Collection from Harvard University, the Meyer
Collection from the Johns Hopkins University, and the Huber-Crosby and
Crosby-Lauer Collections from the University of Michigan.
Our purpose here is to provide some examples of ways in which images
and information from the Collections, in digital format, can be used
in educational, research and commercial enterprises. Millions of
beautifully stained sections from hundreds of different brains,
assembled in many locations over the past century can be made
available for a broad variety of purposes."
Want more pics?
Wikipedia: List of neuroscience databases
en.wikipedia.org/wiki/List_of_neuroscience_databases
Want more neuro imaging software?
UCLA: Laboratory of Neuro-Imaging
Presynaptic microtubules (green) and postsynaptic actins (red) at neuromuscular junction 4. The neuron surface is shown in blue. Credit: Q. Wang and M. Serpe, NICHD
Date: October 2008
Medium: Digital Photography Montage
Dimensions: w 24” x h 24” (Larger and Smaller Sizes Available)
© 2008 Tony DeVarco
The original photo for this piece was taken on May 17, 2008 in San Francisco's Yebra Buena Gardens.
"The synapse is like the soul of the brain."
Jasper Johns
Neurons and astrocytes isolated from rat hippocampus stained for DNA (blue), neuronal-specific βIII-tubulin (green) and astrocyte-specific GFAP (red).
Neurobiology
DISTINCTION FOR CATEGORY 4
Copyright: CC-BY-NC-ND: Rajib Schubert
Description of the author:
Here we are looking into a live awake mouse's brain while it is listening to music. As the music plays, the neurons labelled in green and red with a genetically encoded calcium sensor get activated which allows us to visualise the dance they do as they process the audio input via flashes of electrical activity. This ballad is not only aesthetically pleasing but also very informative as we see how neural processing occurs in real time with a tangible stimulus which we can relate to deep inside.
Comment of the Jury:
A distinction goes to the video “Ballade of the neurons”. The video enables an amazing glimpse into the brain of a mouse as it hears music. Neural processes are shown in real time. “You see the message being transmitted, and you want to know what the message is”, wrote the Jury.
Kommentar der Jury:
Eine Auszeichnung erhält das Video «Neuronenballade». Das Video ermöglicht einen überraschenden Blick in das Gehirn einer Maus, während sie Musik hört. Es zeigt die neuronalen Prozesse in Echtzeit. «Man sieht die Botschaft, die übertragen wird und möchte wissen, was die Botschaft ist», schreibt dazu die Jury.
Commentaire du jury:
La vidéo « Balade neuronale » a reçu une mention. Ce film offre un aperçu étonnant de ce qui se passe dans le cerveau d’une souris qui écoute de la musique. Il montre les processus neuronaux en temps réel. « On voit le message transmis et on voudrait connaître son contenu », commente le jury.
The head houses the brain, a collection of about 950,000 neurons. These neurons are specialized, and they communicate with specific neighboring neurons. This division of tasks is part of why a bee's brain, which is a fraction of the size of the bee's head, can perform complex tasks that might ordinarily require a bigger brain. A system of nerves allows the brain to communicate with the rest of the body.
On its head, a bee has two sensory antennae. It also has five eyes -- three simple eyes, or ocelli, and two compound eyes. The compound eyes are made of lots of small, repeating eye parts called ommatidia. In each compound eye, about 150 ommatidia specialize in seeing patterns. This allows bees to detect polarized light -- something human beings cannot do.
Like most insects, a bee has complex mouth parts that it uses to eat and drink. The sizes and shapes of these parts can vary from species to species, but in general, most have:
Paired mandibles, or jaws
A glossa, or tongue
A labrum and two maxillae
The labrum and maxillae are like lips. They support a proboscis, or tube for collecting nectar.
images.search.yahoo.com/images/view?back=http%3A%2F%2Fsea...
+of+each+part&sigr=15o35s2i2&sigi=15hcvkp66&sigb=11lcmioj8&fr=yfp-t-435-s){kind=link}
Ben A. Barres received his B.S. in Life Sciences from M.I.T. in 1976, his M.D. from Dartmouth Medical School in 1979, and his Ph.D. from Harvard Medical School in 1990. His lab focuses on neuron-glial interactions in the central nervous system and on their relevance to CNS regeneration and remyelination.
He likes home coffee roasting and Harry Potter.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
Painting by Machiko Edmondson. Armory Week 2009. Art Comments coverage at www.artcomments.com. New York, NY
Neural Stimulation Research. hiPSC derived neurons forming networks InVitro allows drug screening of known phenotypes. The plasticity of aligning cells combined with an electronic MIMO interface provides an environment for the study of novel cybernetic interactions.
The Calhoun School's project for Sunday, June 26.
"Most of the activities that create the neuron connections in brains which lead to higher-level academic research and achievement are things that require time and space and experiential education" - Steven J. Nelson, Calhoun’s head of school, speaking to the NY Times about the school's schedule.
Entry in category 4. Video loop; © CC-BY-NC-ND: Mathieu Niquille
Capturing this video in living mouse brain tissue, we stole few intimate minutes of the neuronal migration choreography. The high resolution allows us to appreciate the beauty of their inner dance. How often thousands of hidden and infinitely small phenomena are the anonymous ground of what we agree to call “perfection” is, to me, a drive to stay humble regarding our contribution to science.
Here we looked at the endogenously fluorescent sensing units of interneurons during their journey through the developing brain. Images were acquired every two minutes along 1h20 using the resonant mode of a Nikon A1 confocal microscope through a 60x oil-immersion objective and with a 3x digital zoom. The field of view is 70x60µm and the raw gray scale pictures were turned into REDhot color coding.
Foundations of the Neuron Doctrine
(History of Neuroscience) by Gordon M. Shepherd
Out of their Minds: The Lives and Discoveries of 15 Great Computer Scientists by Dennis Shasha and Cathy Lazere
i102106 147
*deep in the cerebral cortex of our brains live 30 billion neurons who communicate with each other shaping our thoughts. Most are compatible, cooperative and will allow to be dominated by reason. Deep in the recesses of the brain, not much known about them live the "dark" one's, the ones we may not know or want to acknowledge their existence. They are dormant and may stay so throughout our entire lives. But beware of hate, for when out of control, in no time it will awaken the dark one's, inflaming and contaminating all the good neutrons, making murder a most likely result.
Stefan Krikl, 2005; from my diaries
p.s. best viewed on black for effect.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
Confocal microscopy image of an individual transmedulla neuron, called Tm3, in the Drosophila optic lobe. Left panel: photoreceptors (red) and a Tm3 neuron labelled with GFP (green). Right panel: an individual Tm3 neuron (green) and a Tm3 neuron traced from a confocal microscopy image (grey). Credit: P. Muthuirulan and C.H. Lee, NICHD
pieces of pyramidal cells are green, potassium channel (Kv1.5) immunoreactivity is red, & blood vessels look like black holes. at 500x magnification on a confocal microscope.
Por fin os puedo compartir este post… que va cargadito de ilusión… aunque ahora ya repuesta, y con las neuronas frescas vengo a contaros como fue todo!!!..
Lo increíble que puede ser, conocer a gente por internet.. no solo se consiguen grandes amores, si no amistades irrompibles.
Este es el caso de Diana y mio, nos conocimos en un foro de perritos.. sí! De perritos… ella y yo tenemos yorkies, y eso fue lo que poco a poco en cada conversación hizo nuestra amistad tan fuerte.
El año pasado decidieron dar el sí ante el altar, y aunque es verdad… os debo las fotos de los novios, hoy quiero compartirles el momento tan emotivo que vivimos sus amigos y familia el día de su baby shower.
Habichuela, como así le llamo, al ser pequeñito que por ahora vive en la barriguita de Diana, sorprendió a muchos con su llegada, y aunque mas la mami que el papi, siempre va con nervios que espera que todo salga bien ( supongo que todas las mamis pasan por eso ) … a día de hoy, el embarazo va muy bien.
Tal vez este baby shower, fue tan premeditado, antes que fuese concebido habichuela… sabéis esas conversaciones locas q uno tiene, y empieza diciendo.. pues cuando me saque la lotería… pillaré esto o lo otro?..... algo parecido pasó con nosotras, diciendo, el día que tengas una bebe, hay que hacer un baby shower!!!, y es que claro, aquí en España no se suele vivir así, aunque, esto va entrando poco a poco.
Con todas las ilusiones puestas, me puse en ello, y aunque confieso que fue muuuuuy agotador, sobre todo por terminar pedidos en Barcelona, cuadrar todo lo del curso, y proyectos que por ahora … no os puedo contar.. todo se me hizo muy grande.
Llegue a Valencia, con la tarta para 40 personas, sobre las piernas, no podía ni moverme ni un poquito por miedo a que se estropeara algo, 4 horas en coche … una tortura!, sin embargo, puedo decir que VALIO LA PENA!!!!... como le digo a Diana… por mi habichuela… todo y más!!!...
40 galletas decoradas con fondant, y cerca de 70 mini cupcakes, de crema de queso con mago, y chocolate con almendra, fueron lo que acompañaron a la mesa dulce.
Todo decorado con mis ilustraciones de niña y niño… fue un momento tan pero tan bonito… que me da nostalgia recordarlo.
Lo curioso de todo, que fui la primera en enterarme que Habichuela venía a este mundo y como guinda del pastel, fui la única que sabía si era niño o niña, al momento de hacerle la eco a ella, solo estaba ella y el marido, evidentemente, el doctor se lo dijo a Javi, y este me lo dijo a mi, para poder realizar toda la fiesta, confieso que guardar tremeeeeeendo secreto fue horrible!! Mas cuando a diario conversaba con ella, y hablar del bebe en masculino o femenino era delicado.
Y la pregunta es… y como revelabais si era niña o niño? .. muy fácil! Solo tenían que partir el pastel, y dependiendo del color del bizcocho, rosa o celeste, se sabía que era ¡!!.. a muchos se nos escapó la lagrimita… fue un momento completamente memorable!!!...
Aquí os dejo todo el reportaje fotográfico, bastante largo, pero muy completo! Que espero que os guste mucho.
En breve subiré a nuestra tienda de Artesanio, toda la colección de babyshower para vuestra mesa dulce.
Una vez mas, muchísimas gracias por leernos ^__^
Fanno fatica i miei neuroni in un'afosa giornata estiva a carburare.
Ho caldo, ho davvero caldo.
Sono buttata sul letto avvolta da apatia e sudore, a braccia aperte. Stamattina non ho nemmeno fatto il letto.
Guardo in aria e come al solito mi aspetto che la madonna vestita con body nero e calze a rete scenda per darmi la definitiva benedizione e consacrarmi alla follia o concedermi il beneficio dell'illuminazione divina. E come al solito invece la vergine puttana non esiste e io in un semicollasso spontaneo perdo ogni logica e mi abbandono alla mia solita masturbazione mentale (che non porta assolutamente nessun beneficio, ma, al contrario, danneggia gravemente). E penso alle cose più svariate...
Cazzo! I "becchi di cicogna" sono davvero antiestetici, la testa mi prude, dovrei andare a fare una doccia. Mi rompo troppo. Dopo. Io mantengo la parola data!
Già, oggi è la classica giornata rotta di cazzo, quando le palle girano a mille e quando fai il resoconto degli ultimi avvenimenti, perchè ancora non avevi avuto il tempo di fermarti a riflettere.
Sdegno, c'è tanto sdegno nell'aria perchè penso alle tante parole dette e ascoltate : INUTILI.
Non arrivo a capire molte cose, e mentre il computer emana musiche ministriche penso al caos da big bang che ho nella testa, penso alle responsabilità di cui potrei e vorrei lavarmi le mani e che invece si accumulano e mi fanno sentire in colpa anche di cose di cui non dovrei. Penso ai giochetti delle persone, penso allo scomparire e ricomparire di illusionistiprendiperculo, penso a falsi sorrisi di opportunisti. Penso alle promesse degli amici, che amo, follemente, ma che non ci sono, che sono "momentaneamente" impegnati, ma non li condanno nè giudico. La solitudine mi appartiene da sempre. Se ci sono tanto meglio, se no sticazzi, si fa come ho sempre fatto. Penso che non sto facendo foto, penso che dovrei studiare, penso che odio i conoscenti, penso che le famiglie si sgretolano e che non ci sono soldi, c'è la crisi, c'è la fottutissima crisi.
Penso che stare in casa per troppo tempo non faccia bene, si, ne sono pienamente convinta. Altro che casalinghe disperate!
Io sto sul letto, così e la macchina lì sulla mensola.
E mentre non trovo le risposte è arrivata, è arrivata l'idea per una foto.