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In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
#deepdream code informatique de l'intelligence artificielle de Google spécifique "Fractal DDC " développé et dédié pour un nouvel art à La Demeure du Chaos - The Abode of Chaos ou comment les machines perçoivent La Demeure du Chaos - The Abode of Chaos
et si leurs regards étaient ce qui se cache derrière la matrice que nous percevons en tant qu'humains? ces multiples miroirs sont peut-être un autre monde plus réel ou plus éthéré... NB thierry bonne lecture de ce post et ses images dantesques.
Depuis quelques temps vous avez peut-être vu circuler sur les réseaux sociaux des images étranges, affublées d'un hashtag (mot-clé) #deepdream.
Deep Dream est un programme d'intelligence artificielle mis au point par les ingénieurs de Google. Ces derniers travaillent à la reconnaissance d'images pour, entre autres, améliorer la pertinence des recherches dans Google. Le 17 juin dernier ils ont publié un billet intitulé : "Inceptionnisme : plus loin dans les réseaux neuronaux".
Dans ce post ils expliquent comment ils ont réussi, dans leurs recherches, à faire analyser une image mais surtout générer des formes par l'ordinateur. Pour que l'intelligence artificielle puisse mieux reconnaître ce qui compose une image, les ingénieurs ont commencé par lui montrer des millions de photos.
Plusieurs couches de neurones
L'intelligence artificielle fonctionne ici en un ensemble de réseaux de neurones qu'il faut se figurer comme différentes couches. La première est chargée de regarder les bords et les angles d'une image.
Les couches intermédiaires cherchent quant à elles les formes et les différents éléments présents dans l'image comme une feuille ou une porte. Les derniers réseaux assemblent toutes ces informations pour en fournir des interprétations complexes, comme des arbres ou des bâtiments.
Pour comprendre au mieux comment fonctionnent ces couches, les ingénieurs ont tenté de pousser l'analyse de certaines. Ils résument ainsi la commande faite au système : "Quoi que tu vois, on veut le voir encore plus." C'est alors que l'intelligence artificielle a généré des formes au sein des clichés.
"Si un nuage ressemble un petit peu à un oiseau, alors le système va le faire ressembler encore plus à un oiseau, expliquent les ingénieurs. En réitérant l’action, le programme va reconnaître un oiseau plus fortement et ainsi de suite jusqu’à ce qu’un oiseau très détaillé apparaisse, comme sorti de nulle part."
"L'inceptionnisme"
Les images varient selon le réseau neuronal qui est amplifié. Par exemple, plus on sollicite les couches inférieures, plus des traits vont apparaître. Si on stimule d'avantage les couches supérieures, ce sont des objets qui émergent de l'image.
Les ingénieurs précisent d'ailleurs que comme l'ordinateur a enregistré beaucoup de clichés d'animaux durant son entraînement, il en reproduit souvent. Et parfois en les mixant, ce qui crée des créatures étranges.
Pour ces chercheurs, le Deep Dream a ainsi créé un mouvement artistique qu'ils appellent "l'#inceptionnisme", en référence à l'architecture des réseaux neuronaux.
Au début, cette expérimentation ne cherchait qu'à améliorer l'intelligence artificielle. Mais lorsque les ingénieurs ont posté ce billet, de nombreux internautes se sont intéressés à ce Deep Dream.
Google a donc rendu public le code utilisé pour générer ces images. Des informaticiens s'en sont emparés et ont mis au point des logiciels et des interfaces pour que les internautes puissent s'en servir.
Ce qui ne manque pas de plaire à Google. Les chercheurs encouragent à taguer les images #deepdream sur Twitter, Facebook ou Google+. "Il sera intéressant de voir quelles images les gens arrivent à générer", écrivent-ils.
Gero Misenböck gives a talk about optogenetics.
Strangely, this is the inorganic chemistry building, but those formulas on the blackboard are very organic.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
(1)
Connectome
In their words:
"A connectome is a synapse-resolution mapping of connections between
all neurons in a model organism's brain. In other words, a
synapse-resolution circuit diagram of the brain. Current approaches to
mapping the connectomes of model organisms employ serial block face
scanning electron microscopy (SBF-SEM) and transmission electron
microscopy (TEM). The only connectome that has been mapped out to date
has been from the flatworm, C. elegans, which has only around 300
neurons."
(2)
ConnectomeViewer
In their words:
"The field of Connectomics research benefits from recent advances in
structural neuroimaging technologies on all spatial scales. The need
for software tools to visualize and analyse the emerging data is
urgent. ... The Connectome Viewer application was developed to meet
the needs of basic and clinical neuroscientists, as well as complex
network scientists, providing an integrative, extensible platform to
visualize and analyze Connectomics data.With the Connectome File
Format, interlinking different datatypes such as networks, surface
data, and volumetric data is easy and might provide new ways of
analyzing and interacting with data."
In addition to the viewer, this site also provides quite a variety of
that can be used to test different features and functions.
(3)
Human Connectome Project
In their words:
"The HCP will map the human connectome as accurately as possible in a
large number of normal adults and will make this data freely available
to the scientific community using a powerful, user-friendly
informatics platform."
"Successful charting of the human connectome in normal adults will be
enormously informative. Even more importantly, it will pave the way
for studies that reveal how brain circuitry changes during development
and aging and how it differs in numerous neurological and psychiatric
disorders. In short, it will transform our understanding of the human
brain in health and disease."
(4)
BrainMaps
In their words:
"Brain atlases have traditionally been one resolution and
non-interactive. The next-generation brain atlas is multiresolution,
highly interactive, and fully integrated with the latest research
literature. This is BrainMaps.org, a complete online brain atlas
founded on the principle that a brain atlas is a dynamic, interactive,
multiresolution research and didactic tool that facilitates brain
exploration and knowledge discovery."
As if that isn't enough, BrainMaps also has an API for
developers and and open source /
OpenGL-based 3D
viewer!
(5)
BrainMeta
In their words:
"BrainMeta was established for the purpose of accelerating the
development of neuroscience through web-based initiatives, which
include the development, implementation and support of a wide range of
neuroinformatics tools, services, and databases."
(6)
Allen Institute for Brain Science: Brain Atlas
In their words:
"A growing collection of online public resources integrating extensive
gene expression and neuroanatomical data, complete with a novel suite
of search and viewing tools."
(7)
Brain Museum: Comparative Mammalian Brain Collections
www.brainmuseum.org/index.html
In their words:
"This web site provides browsers with images and information from one
of the world's largest collection of well-preserved, sectioned and
stained brains of mammals. Viewers can see and download photographs of
brains of over 100 different species of mammals (including humans)
representing over 20 Mammalian Orders."
(8)
MSU: Brain Biodiversity Bank
www.msu.edu/~brains/index.html
In their words:
"The Brain Biodiversity Bank refers to the repository of images of and
information about brain specimens contained in the collections
associated with the National Museum of Health and Medicine at the
Armed Forces Institute of Pathology in Washington, DC. These
collections include, besides the Michigan State University Collection,
the Welker Collection from the University of Wisconsin, the
Yakovlev-Haleem Collection from Harvard University, the Meyer
Collection from the Johns Hopkins University, and the Huber-Crosby and
Crosby-Lauer Collections from the University of Michigan.
Our purpose here is to provide some examples of ways in which images
and information from the Collections, in digital format, can be used
in educational, research and commercial enterprises. Millions of
beautifully stained sections from hundreds of different brains,
assembled in many locations over the past century can be made
available for a broad variety of purposes."
Want more pics?
Wikipedia: List of neuroscience databases
en.wikipedia.org/wiki/List_of_neuroscience_databases
Want more neuro imaging software?
UCLA: Laboratory of Neuro-Imaging
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
Retinal ganglion fibers (green) convey visual information to the zebrafish tectum, or midbrain, where they overlap with fibers from dorsal raphe neurons, which signal arousal (red). Credit: NICHD
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
CRISPR/Cas9 engineering was used in mouse embryonic stem cells to insert a GFP tag in frame with the motor-neuron-specific transcription factor HB9. These cells were differentiated into motor neurons. The resulting motor neuron nuclei are labeled with the GFP reporter (green) and counterstained with antibodies against the neuronal marker Tuj1 (red). Credit: T. Macfarlan, NICHD
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In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
In Naked Knotted Neurons, a group of protesters, some injured, some choking on tear gas, escape violent confrontation with police and other forces by staggering into a safe house they find in the midst of chaos. Strangers to one another, they soon discover they are from different worlds: all were involved in protests, but in different places and times. A trio of dieties, Fate, Chance and Destiny, have gathered them together to charge them with a task: to create a new Hero to solve the world’s most intractable, knotted problems. How to get this message across? Puppets, riddles, and audience participation reveal the secrets the protesters need to fulfill this task.
Following their run at the International Fringe Festival in Edinburgh, Scotland, the Penn Theatre Ensemble presented the company-devised piece Naked Knotted Neurons at Annenberg Center Live on September 4th and 5th, 2015.
Wide ruled, 9 3/4in. x 7 1/2in., 100 Paged Notebook covered and spray painted lime green. Stenciled with a black neuron. Stencil is a one of a kind, hand drawn paper cut.
Infection of neurons (red) by the PRV α-herpesvirus (green) induces axonal swellings (arrows) that serve as exit sites for the virus to infect neighboring cells. (JCB 174(2) TOC2)
This image is available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
Reference: De Regge et al. (2006) J. Cell Biol. 174:267-275.
Published on: July 10, 2006.
Doi: 10.1083/jcb.200510156.
Read the full article at: