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The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
About Center for Biomaterials at Rutgers, The State University of New Jersey
Center for Biomaterials is a Multidisciplinary Center of Excellence for Tissue Engineering, Regenerative Medicine, Drug Delivery, Medical Devices, and Workforce Development based at Rutgers, The State University of New Jersey - that spans academia, industry and government.
As biomaterials scientists, our goal is to conduct state-of-the-art research in biomaterials science and engineering and to improve health care and the quality of life by developing advanced biomedical products for tissue repair and replacement, and the delivery of pharmaceutical agents. Our advanced research projects with licensing or partnering opportunities are in bone, nerve, drug delivery and X-ray visible medical implants. Our technologies have been translated into pre-clinical and clinical products, including a fully resorbable and x-ray visible coronary stent, an antimicrobial implant for the prevention of pacemaker infections, a surgical mesh for hernia repair, a bone regeneration scaffold and an ocular drug delivery system for the treatment of inflammatory eye disorders.
We have collaborations using additive manufacturing (3D printing), polymer processing, and scale-up of polymer synthesis. Our major facilities include certified class 10,000 (EN/ISO-14644 Class 7 US federal Standard 209) cleanroom. We have a large network of 60+ Industry collaborators and 30+ National and International Institutions. NJCBM also provides educational and workforce training for scientists and students in biomaterials and regenerative medicine and hosts Annual Symposia on "Biomaterials Science."
About Rutgers, The State University of New Jersey
Rutgers, The State University of New Jersey, is a leading national research university and the state of New Jersey's preeminent, comprehensive public institution of higher education. Established in 1766, the university is the eighth oldest higher education institution in the United States. Nearly 69,000 students and 22,000 full- and part-time faculty and staff learn, work, and serve the public at Rutgers locations across New Jersey and around the world. The university belongs to the Big Ten Academic Alliance, comprised of 14 world-class research universities, and is among the top 20 public U.S. universities for total R&D funding. Rutgers University-New Brunswick is the state's only public institution in the prestigious Association of American Universities.
As the premier public research university in the state, Rutgers is dedicated to teaching that meets the highest standards of excellence, to conducting cutting-edge research that breaks new ground and aids the state's economy, businesses, and industries, and to providing services, solutions, and clinical care that help individuals and the local, national, and global communities where they live. ored.rutgers.edu
Growing Sculpture In Bone: Leveraging the intelligence of human stem cells, Amy Karle created “Regenerative Reliquary”, 2016, a scaffold in the shape of a human hand design 3D printed in a biodegradable pegda hydrogel that disintegrates over time with the intention that stem cells seeded onto that design will eventually grow into tissue and mineralize into bone.
credit: Charlie Nordstrom
Entry in category 1. Object of study; Copyright CC-BY-NC-ND: Vera M. Kissling
A hydrogel coating with boron-containing nanoparticles to fight off drug-resistant bacteria, prepared on a glass slide by Dr. Giacomo Reina and imaged by Dr. Vera M. Kissling using a scanning electron microscope. Energy Dispersive X-ray Spectroscopy detection shows the presence of boron in the hydrogel, coloring it in blue, and silica in the glass slide (yellow). Intriguingly, this microscopic beach mirrors our macroscopic world, where our oceans contain most of the boron found on Earth and the sand of shores is made of silica.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
About Center for Biomaterials at Rutgers, The State University of New Jersey
Center for Biomaterials is a Multidisciplinary Center of Excellence for Tissue Engineering, Regenerative Medicine, Drug Delivery, Medical Devices, and Workforce Development based at Rutgers, The State University of New Jersey - that spans academia, industry and government.
As biomaterials scientists, our goal is to conduct state-of-the-art research in biomaterials science and engineering and to improve health care and the quality of life by developing advanced biomedical products for tissue repair and replacement, and the delivery of pharmaceutical agents. Our advanced research projects with licensing or partnering opportunities are in bone, nerve, drug delivery and X-ray visible medical implants. Our technologies have been translated into pre-clinical and clinical products, including a fully resorbable and x-ray visible coronary stent, an antimicrobial implant for the prevention of pacemaker infections, a surgical mesh for hernia repair, a bone regeneration scaffold and an ocular drug delivery system for the treatment of inflammatory eye disorders.
We have collaborations using additive manufacturing (3D printing), polymer processing, and scale-up of polymer synthesis. Our major facilities include certified class 10,000 (EN/ISO-14644 Class 7 US federal Standard 209) cleanroom. We have a large network of 60+ Industry collaborators and 30+ National and International Institutions. NJCBM also provides educational and workforce training for scientists and students in biomaterials and regenerative medicine and hosts Annual Symposia on "Biomaterials Science."
About Rutgers, The State University of New Jersey
Rutgers, The State University of New Jersey, is a leading national research university and the state of New Jersey's preeminent, comprehensive public institution of higher education. Established in 1766, the university is the eighth oldest higher education institution in the United States. Nearly 69,000 students and 22,000 full- and part-time faculty and staff learn, work, and serve the public at Rutgers locations across New Jersey and around the world. The university belongs to the Big Ten Academic Alliance, comprised of 14 world-class research universities, and is among the top 20 public U.S. universities for total R&D funding. Rutgers University-New Brunswick is the state's only public institution in the prestigious Association of American Universities.
As the premier public research university in the state, Rutgers is dedicated to teaching that meets the highest standards of excellence, to conducting cutting-edge research that breaks new ground and aids the state's economy, businesses, and industries, and to providing services, solutions, and clinical care that help individuals and the local, national, and global communities where they live. ored.rutgers.edu
Le biomimétisme propose le vivant comme modèle.
Incroyablement performante et résiliante, la nature est une source d'inspiration infinie pour innover, réinventer nos modes d'organisation et de développement, et remettre l'humanité en résonance avec son environnement.
La Biomim’review propose une galerie d’exemples d’innovations bio-inspirées.
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Agence conseil en stratégie, communication, RSE et Biomimétisme ; associé fondateur du Ceebios.
Le livret qui compile une série de fiches exemples est disponible sur commande. Relié, format double A4.
La série de fiches Biomim'review est également disponible sur demande.
Prenez contact svp via l'adresse contact@biomimexpo.com
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
About Center for Biomaterials at Rutgers, The State University of New Jersey
Center for Biomaterials is a Multidisciplinary Center of Excellence for Tissue Engineering, Regenerative Medicine, Drug Delivery, Medical Devices, and Workforce Development based at Rutgers, The State University of New Jersey - that spans academia, industry and government.
As biomaterials scientists, our goal is to conduct state-of-the-art research in biomaterials science and engineering and to improve health care and the quality of life by developing advanced biomedical products for tissue repair and replacement, and the delivery of pharmaceutical agents. Our advanced research projects with licensing or partnering opportunities are in bone, nerve, drug delivery and X-ray visible medical implants. Our technologies have been translated into pre-clinical and clinical products, including a fully resorbable and x-ray visible coronary stent, an antimicrobial implant for the prevention of pacemaker infections, a surgical mesh for hernia repair, a bone regeneration scaffold and an ocular drug delivery system for the treatment of inflammatory eye disorders.
We have collaborations using additive manufacturing (3D printing), polymer processing, and scale-up of polymer synthesis. Our major facilities include certified class 10,000 (EN/ISO-14644 Class 7 US federal Standard 209) cleanroom. We have a large network of 60+ Industry collaborators and 30+ National and International Institutions. NJCBM also provides educational and workforce training for scientists and students in biomaterials and regenerative medicine and hosts Annual Symposia on "Biomaterials Science."
About Rutgers, The State University of New Jersey
Rutgers, The State University of New Jersey, is a leading national research university and the state of New Jersey's preeminent, comprehensive public institution of higher education. Established in 1766, the university is the eighth oldest higher education institution in the United States. Nearly 69,000 students and 22,000 full- and part-time faculty and staff learn, work, and serve the public at Rutgers locations across New Jersey and around the world. The university belongs to the Big Ten Academic Alliance, comprised of 14 world-class research universities, and is among the top 20 public U.S. universities for total R&D funding. Rutgers University-New Brunswick is the state's only public institution in the prestigious Association of American Universities.
As the premier public research university in the state, Rutgers is dedicated to teaching that meets the highest standards of excellence, to conducting cutting-edge research that breaks new ground and aids the state's economy, businesses, and industries, and to providing services, solutions, and clinical care that help individuals and the local, national, and global communities where they live. ored.rutgers.edu
Printed on the EnvisionTEC 3D Bioplotter by Shah Lab at Northwestern University for tissue and organ regeneration.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
Genauso vielfältig wie Art und Ort der Wunden sind auch die Produkte zur Wundversorgung. Bei Verbrennungswunden kommen beispielweise Hydrogele, antibakterielle Wundauflagen und Schutzverbände zum Einsatz.
Quelle: Bundesverband Medizintechnologie (BVMed)
Honorarfreie Verwendung im redaktionellen Kontext.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
About Center for Biomaterials at Rutgers, The State University of New Jersey
Center for Biomaterials is a Multidisciplinary Center of Excellence for Tissue Engineering, Regenerative Medicine, Drug Delivery, Medical Devices, and Workforce Development based at Rutgers, The State University of New Jersey - that spans academia, industry and government.
As biomaterials scientists, our goal is to conduct state-of-the-art research in biomaterials science and engineering and to improve health care and the quality of life by developing advanced biomedical products for tissue repair and replacement, and the delivery of pharmaceutical agents. Our advanced research projects with licensing or partnering opportunities are in bone, nerve, drug delivery and X-ray visible medical implants. Our technologies have been translated into pre-clinical and clinical products, including a fully resorbable and x-ray visible coronary stent, an antimicrobial implant for the prevention of pacemaker infections, a surgical mesh for hernia repair, a bone regeneration scaffold and an ocular drug delivery system for the treatment of inflammatory eye disorders.
We have collaborations using additive manufacturing (3D printing), polymer processing, and scale-up of polymer synthesis. Our major facilities include certified class 10,000 (EN/ISO-14644 Class 7 US federal Standard 209) cleanroom. We have a large network of 60+ Industry collaborators and 30+ National and International Institutions. NJCBM also provides educational and workforce training for scientists and students in biomaterials and regenerative medicine and hosts Annual Symposia on "Biomaterials Science."
About Rutgers, The State University of New Jersey
Rutgers, The State University of New Jersey, is a leading national research university and the state of New Jersey's preeminent, comprehensive public institution of higher education. Established in 1766, the university is the eighth oldest higher education institution in the United States. Nearly 69,000 students and 22,000 full- and part-time faculty and staff learn, work, and serve the public at Rutgers locations across New Jersey and around the world. The university belongs to the Big Ten Academic Alliance, comprised of 14 world-class research universities, and is among the top 20 public U.S. universities for total R&D funding. Rutgers University-New Brunswick is the state's only public institution in the prestigious Association of American Universities.
As the premier public research university in the state, Rutgers is dedicated to teaching that meets the highest standards of excellence, to conducting cutting-edge research that breaks new ground and aids the state's economy, businesses, and industries, and to providing services, solutions, and clinical care that help individuals and the local, national, and global communities where they live. ored.rutgers.edu
Co-culture of human macrophages with human mesenchymal stem cells (hMSCs) in a three-dimensional hydrogel scaffold for 15 days. Green: hMSCs; Blue: Live cells (hMSCs & macrophages); Red: Dead cells.
Credit: Stanford University Photo/Monica Lopez and Stuart Goodman
Lew Semprini, left, and Mitchell Rasmussen in the lab where groundwater-purifying hydrogel beads are made (photo courtesy OSU College of Engineering).
by Jesse Gatlin, University of Wyoming
Co-submitters: Abdullah Bashar Sami, April Kloxin, John Oakey
The microtubule cytoskeleton acts as a scaffold the cell uses to arrange and move its internal parts. This network of filamentous polymers is dynamic, constantly building and rebuilding itself to achieve different functional forms during different stages of the cell cycle. In interphase, microtubules organize into an arborous, astral array whose position dictates where the cell division machinery assembles during the next mitosis. To better understand the biophysical mechanisms that direct this positioning, we confine microtubule asters in cell-free extracts using photo-patterned hydrogel micro-enclosures and then visualize their behavior using time-lapse confocal microscopy. In this example, microtubules are labeled with an mCherry-Tau variant (red) and their growing ends with EB1-GFP (green). The enclosure is ~60 µm in diameter and the playback speed is 200x.
Hydrogel Silicon contact lens in keratoconus patient without ICRS surgery// Lente de contacto de hidrogel de silicona en paciente con queratocono sin cirugia de anillos. Cortesía/Courtesy Nuria Villalón
Printed on the EnvisionTEC 3D Bioplotter by Shah Lab at Northwestern University for tissue and organ regeneration.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
Printed on the EnvisionTEC 3D Bioplotter by Shah TEAM lab at Northwestern University.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
Anne Gillies, Fordson High School teacher, generates an alginate hydrogels for synthetic organs during a workshop in the NCRC on North Campus of the University of Michigan in Ann Arbor, MI on June 26, 2017.
The workshop is part of the Research Education and Activities for Classroom Teachers (REACT), providing education and resources for K-12 educators to learn and implement STEM researcher into their respective schools.
Photo: Joseph Xu/Senior Multimedia Content Producer, University of Michigan - College of Engineering
Audra Winter: Pharmaceutical Chemistry
Summer Undergraduate Research Fellowship (SURF)
Audra Winter, Advisor: Bruce Lee
Development of PEG-based Hydrogel Functionalized with SNAP or Release NO as a Novel Antibacterial Material
www.flickr.com/photos/michigantechcoe/sets/72157635041162...
Vespers, 2018. Photopolymers: Escherichia coli bacteria, hydrogel, chemical signals. New Ancient Collection. SFMOMA
Leveraging the intelligence of human stem cells, Amy Karle created Regenerative Reliquary a bioprinted scaffold in the shape of a human hand 3D-printed in a biodegradable PEGDA-hydrogel that disintegrates over time. The sculpture is installed in a bioreactor, with the intention that human Mesenchymal stem cells (hMSCs from an adult donor) seeded onto this design will eventually grow into tissue and mineralize into bone on the scaffold.
Credit: Ars Electronica / Vanessa Graf
PI: Subramanian Sankaranarayanan, Argonne National Laboratory
Conformational dynamics across lower critical solution temperature in a polymer brush structure grafted on metal nanoparticle.
Image credit: Sanket Deshmukh, Ganesh Kamath, Derrick Mancini, and Subramanian Sankaranarayanan, Argonne National Laboratory
Scientific Discipline: Materials Science
This research used resources of the Argonne Leadership Computing Facility at Argonne National Laboratory.
Printed on the EnvisionTEC 3D Bioplotter by Shah TEAM lab at Northwestern University.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
Printed on the EnvisionTEC 3D Bioplotter by Shah TEAM lab at Northwestern University.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
These images are from a TAH-BSO specimen obtained many years after the patient underwent uterine artery embolization (UAE) with polyvinyl alcohol microspheres for treatment of symptomatic leiomyomas. The largest leiomyoma was almost completely infarcted. Embolic material was seen in the uterus, tubes and ovaries. Chronic inflammation, fibrosis and giant cells are present around the microspheres.
Uterine artery embolization (UAE), performed by interventional radiologists, is a frequently utilized alternative to surgical treatment of symptomatic uterine leiomyomas (fibroids). The goal of embolotherapy is to produce infarction and, thereby, shrinkage of the leiomyomas.
A variety of embolic agents are approved by the U.S. Food and Drug Administration (FDA) for UAE. These include tris-acryl gelatin microspheres (TAGM; Embospheres, Merit, South Jordan, UT) , nonspherical and spherical polyvinyl alcohol (PVA) particles (various manufactures), calibrated acrylamido polyvinyl alcohol microspheres (a-PVAM; Bead Block, BTG, West Conshohocken, PA). Polyzene F–coated microsphere (Embozene, Boston Scientific) is the most recent addition of embolic agents for UAE. This agent consists of a hydrogel core of polymethylmethacrylate and a flexible shell of polyphosphazene, a synthesized inorganic biostable and biocompatible polymer.
Follow-up studies utilizing surgical specimens have shown that the embolic material is mainly present in leiomyomas and non-neoplastic myometrium but is also found in non-targeted sites such as cervix, endometrium, ovaries and fallopian tubes. Infarction is confined to leiomyomas.
Embolic material can cause vascular damage resulting in pseudoaneurysms. These are thought to be responsible for the finding of embolic material in extravascular spaces, usually in close proximity to damaged arteries.
Images contributed by Dr. Monika Vyas - @Mvgs1706
References:
-Maleki Z et al. Int J Gynecol Pathol; 2010; 29:260-268
-Chiesa AG, Hart WR. Int J Gynecol Pathol; 2004; 23:386-392.
-Kohi MP, Spies JB. Updates on Uterine Artery Embolization. Semin Intervent Radiol. 2018;35(1):48–55. doi:10.1055/s-0038-1636521
Printed on the EnvisionTEC 3D Bioplotter by Shah TEAM lab at Northwestern University.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
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These images show the microscopic appearance of trisacryl gelatin microsoheres utilized as an embolic material for the treatment of symptomatic uterine leiomyomas.
Uterine artery embolization (UAE), performed by interventional radiologists, is a frequently utilized alternative to surgical treatment of symptomatic uterine leiomyomas (fibroids). The goal of embolotherapy is to produce infarction and, thereby, shrinkage of the leiomyomas.
A variety of embolic agents are approved by the U.S. Food and Drug Administration (FDA) for UAE. These include tris-acryl gelatin microspheres (TAGM; Embospheres, Merit, South Jordan, UT) , nonspherical and spherical polyvinyl alcohol (PVA) particles (various manufactures), calibrated acrylamido polyvinyl alcohol microspheres (a-PVAM; Bead Block, BTG, West Conshohocken, PA). Polyzene F–coated microsphere (Embozene, Boston Scientific) is the most recent addition of embolic agents for UAE. This agent consists of a hydrogel core of polymethylmethacrylate and a flexible shell of polyphosphazene, a synthesized inorganic biostable and biocompatible polymer.
Follow-up studies utilizing surgical specimens have shown that the embolic material is mainly present in leiomyomas and non-neoplastic myometrium but is also found in non-targeted sites such as cervix, endometrium, ovaries and fallopian tubes. Infarction is confined to leiomyomas.
Embolic material can cause vascular damage resulting in pseudoaneurysms. These are thought to be responsible for the finding of embolic material in extravascular spaces, usually in close proximity to damaged arteries.
The assistance of Dr. Monika Vyas - @Mvgs1706 is gratefully acknowledged
References:
-Maleki Z et al. Int J Gynecol Pathol; 2010; 29:260-268
-Chiesa AG, Hart WR. Int J Gynecol Pathol; 2004; 23:386-392.
-Kohi MP, Spies JB. Updates on Uterine Artery Embolization. Semin Intervent Radiol. 2018;35(1):48–55. doi:10.1055/s-0038-1636521
Printed on the EnvisionTEC 3D Bioplotter by Shah TEAM lab at Northwestern University.
The 3D-Bioplotter® System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The 3D-Bioplotter® has the capacity of fabricating scaffolds using the widest range of materials of any singular rapid prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.
3D-Bioplotter®
envisiontec.com/3d-printers/3d-bioplotter/
Shah TEAM lab
This chart shows the distinguishing features of poylvinyl alcohol (PVA) particles and microspheres and trisacryl gelatin microspheres (TGM) that are utilized for uterine artery embolization for treatment of symptomatic uterine leiomyomas,
Uterine artery embolization (UAE), performed by interventional radiologists, is a frequently utilized alternative to surgical treatment of symptomatic uterine leiomyomas (fibroids). The goal of embolotherapy is to produce infarction and, thereby, shrinkage of the leiomyomas.
A variety of embolic agents are approved by the U.S. Food and Drug Administration (FDA) for UAE. These include tris-acryl gelatin microspheres (TAGM; Embospheres, Merit, South Jordan, UT) , nonspherical and spherical polyvinyl alcohol (PVA) particles (various manufactures), calibrated acrylamido polyvinyl alcohol microspheres (a-PVAM; Bead Block, BTG, West Conshohocken, PA). Polyzene F–coated microsphere (Embozene, Boston Scientific) is the most recent addition of embolic agents for UAE. This agent consists of a hydrogel core of polymethylmethacrylate and a flexible shell of polyphosphazene, a synthesized inorganic biostable and biocompatible polymer.
Follow-up studies utilizing surgical specimens have shown that the embolic material is mainly present in leiomyomas and non-neoplastic myometrium but is also found in non-targeted sites such as cervix, endometrium, ovaries and fallopian tubes. Infarction is confined to leiomyomas.
Embolic material can cause vascular damage resulting in pseudoaneurysms. These are thought to be responsible for the finding of embolic material in extravascular spaces, usually in close proximity to damaged arteries.
The assistance of Dr. Monika Vyas - @Mvgs1706 is gratefully acknowledged
References:
-Maleki Z et al. Int J Gynecol Pathol; 2010; 29:260-268
-Chiesa AG, Hart WR. Int J Gynecol Pathol; 2004; 23:386-392.
-Kohi MP, Spies JB. Updates on Uterine Artery Embolization. Semin Intervent Radiol. 2018;35(1):48–55. doi:10.1055/s-0038-1636521
June 18, 2021-- A hydrogel that forms a barrier to keep heart tissue from adhering to surrounding tissue after surgery was developed and successfully tested in rodents by a team of University of California San Diego researchers. The team of engineers, scientists and physicians also conducted a pilot study on porcine hearts, with promising results.
They describe their work in the June 18, 2021 issue of Nature Communications.
These are the magnified particulates from the sputum expelled by the body with hydrogel pockets encasing them.
Embozene® microspheres are spherical, tightly calibrated, biocompatible, non-resorbable, hydrogel microspheres coated with an inorganic perfluorinated polymer (Polyzene®-F). They are available in a range of sizes suitable for embolic therapy. Embozene® Microspheres are available as colored and opaque (non-colored) microspheres. Colored microspheres are color coded by size.
In this case they were therapeutically embolized to the liver to treat a hepatic neoplasm.
Images contributed by Dr. Michael Feely - @MFeelyDO
Shannon Bakarich, a PhD candidate at the ARC Centre of Excellence for Electromaterials Science, has come up with a solution in the form of 3D printed, fibre-reinforced hydrogels.To create his toughened hydrogel, Shannon simultaneously prints with two inks on a 3D printer customised with a UV curing system. One ink cures into a soft and wet hydrogel and the other, to a hard and stiff plastic which forms the reinforcing ‘fibres’ within the structure.
Tissue from the skeletal muscle of pigs is spun in detergent until only the fibrous extracellular matrix remains.
Dilapan-S ® is an osmotic hygroscopic dilator produced from a patented Aquacryl ® hydrogel. It is a rigid gel stick that increases in volume by absorbing fluids from the cervical canal, thereby gradually dilating the cervix. The 4 mm thin rod can expand up to 15 mm in 12-24 hours. This allows to gradually dilate and soften the cervix. Simultaneously, Dilapan-S ® initiates the release of endogenous prostaglandin that causes collagen degradation that softens the cervix.
This cervical dilator arrived in a sample container along with a stillborn fetus.
Images contributed by Dr. Leon Metlay - @leon_metlay
Leveraging the intelligence of human stem cells, Amy Karle created Regenerative Reliquary a bioprinted scaffold in the shape of a human hand 3D-printed in a biodegradable PEGDA-hydrogel that disintegrates over time.
The sculpture is installed in a bioreactor, with the intention that human Mesenchymal stem cells (hMSCs from an adult donor) seeded onto this design will eventually grow into tissue and mineralize into bone on the scaffold.
Credit: Florian Voggeneder
This image shows geometrically defined cellular patterns with hydrogels bioprinted using computer-assisted design software. The circular pattern was created using fibroblast cells engineered to express green or red fluorescent proteins.
Credit: National Center for Advancing Translational Sciences, Paige Derr
Leveraging the intelligence of human stem cells, Amy Karle created Regenerative Reliquary a bioprinted scaffold in the shape of a human hand 3D-printed in a biodegradable PEGDA-hydrogel that disintegrates over time.
The sculpture is installed in a bioreactor, with the intention that human Mesenchymal stem cells (hMSCs from an adult donor) seeded onto this design will eventually grow into tissue and mineralize into bone on the scaffold.
Credit: Florian Voggeneder
Entry in category 1. Object of study; Copyright CC-BY-NC-ND: Outman Akouissi
Electronics matching the mechanics of the human skin or brain allow the creation of wearable and implantable devices for the most diverse healthcare applications. Soft electrical conductors are key for the fabrication of such electronics. To achieve this goal, we are developing a new composite (conductive jello) made of hydrogel and gold nanoparticles.
In this Scanning Electron Microscopy image, two-dimensional gold nanoflakes on the surface of the hydrogel have formed “natural” structures similar to the Pyramides d’Euseigne in Valais. We believe that these structures have formed during the synthesis and processing of the sample, when the flakes protected the underlying gel from drying and external light.
This is another example showing how nature can repeat its structures and geometries at all scales, even at dimension of a millionth of the thickness of a hair.
Leveraging the intelligence of human stem cells, Amy Karle created Regenerative Reliquary a bioprinted scaffold in the shape of a human hand 3D-printed in a biodegradable PEGDA-hydrogel that disintegrates over time.
The sculpture is installed in a bioreactor, with the intention that human Mesenchymal stem cells (hMSCs from an adult donor) seeded onto this design will eventually grow into tissue and mineralize into bone on the scaffold.
Credit: Florian Voggeneder
These Lenses are made of Hydrogel a special material that's approved by the TGA (Therapeutic Goods Administration) for the Australian market.Visit our website pimpmyeyes.com.au to see our latest products and offers.
Polyacrylamide, a polymer of the acrylamide monomer, is a popular colorless hydrogel material that has been shown to be stable, non-toxic, non-allergenic, non-absorbable, and non-biodegradable. It was originally introduced to cosmetic surgery under the name of Royamid in Ukraine in the late 1980s. Medical uses are as an injectable implant and in wound dressings. It has many other uses including water purification and food packaging.
Initially, polyacrylamide appeared to be an ideal soft tissue filler material. However, it has now been demonstrated that numerous complications can occur following polyacrylamide injections. These can develop from several months to several years after injection. They include migration, pain, infection, tissue firmness, and disfigurement.
These images are from the lip of a patient who had polyacrylamide injected for cosmetic purposes. Note the granulomatous reaction to this material best seen in the right image.
Images contributed by Dr. Marro Magalhaes - @Dr_MMagalhaes
Leveraging the intelligence of human stem cells, Amy Karle created Regenerative Reliquary a bioprinted scaffold in the shape of a human hand 3D-printed in a biodegradable PEGDA-hydrogel that disintegrates over time. The sculpture is installed in a bioreactor, with the intention that human Mesenchymal stem cells (hMSCs from an adult donor) seeded onto this design will eventually grow into tissue and mineralize into bone on the scaffold.
Credit: Ars Electronica / Vanessa Graf
ماسك يعمل على ترطيب وتغذية ومعالجة مشاكل البشرة وتجديد الخلايا
العلبة الواحدة تحتوي على 4 ماسكات
68 ريال
Mùa đông này cùng chàng diện lens đôi thì còn gì bằng.Có ai thích được cùng người yêu mang lens đôi không nè . #WINTER mùa đông ấp áp cùng chàng ..
▶ Lens đóng gói Vỉ #Cao_Cấp, Êm Như Không Đeo
▶ Chống tia #UV , trao đổi #Oxygen cực tốt cho mắt.
▶ #SandwichProcess và #AquaCapsule_80% tạo sự êm ái suốt cả ngày dài.
▶ Nhiều người nổi tiếng tin dùng: Châu Bùi, Phở Đặc Biệt, An Japan, Sun HT, Bảo Anh, Blogger Rư , Milan Minh Thư, Yuu Quỳnh Nhi ..v.v.
Bạn có thể tham khảo thêm nhiều mẫu kính áp tròng Silicone Hydrogel tại đây nhé:
niceeyes.vn/collections/silicone-hydrogel/
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