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Apeldoorn 06-11-2024
Defensiekampioenschap Functional Fitness georganiseerd door het Bureau Internationale Militaire Sport, (BIMS)
Apeldoorn 06-11-2024
Defensiekampioenschap Functional Fitness georganiseerd door het Bureau Internationale Militaire Sport, (BIMS)
Apeldoorn 06-11-2024
Defensiekampioenschap Functional Fitness georganiseerd door het Bureau Internationale Militaire Sport, (BIMS)
As per the latest research by PMR, the global functional brain imaging systems market is estimated to account for revenues worth US$ 7 Bn by the end of 2029. The functional brain imaging systems market report also projects a significant growth prospective with a projected average Y-o-Y growth rate of around 7% during the forecast period.
Oirschot, 10 juli 2025
Op de Generaal-majoor Ruyter van Steveninckkazerne in Oirschot vindt het BIMS evenement Functional fitness plaats waarbij verschillende nationaliteiten strijden om podium plaats.
Foto: Medaille uitreiking en BBQ
Apeldoorn 06-11-2024
Defensiekampioenschap Functional Fitness georganiseerd door het Bureau Internationale Militaire Sport, (BIMS)
Photographs from the 2014 Functional Programming eXchange, which took place in London, UK.
Skillscasts (film/code/slides) are available at skillsmatter.com/conferences/1819-functional-programming-...
Apeldoorn 06-11-2024
Defensiekampioenschap Functional Fitness georganiseerd door het Bureau Internationale Militaire Sport, (BIMS)
Oirschot, 10 juli 2025
Op de Generaal-majoor Ruyter van Steveninckkazerne in Oirschot vindt het BIMS evenement Functional fitness plaats waarbij verschillende nationaliteiten strijden om podium plaats.
Foto: Medaille uitreiking en BBQ
In-silico functional annotation of a hypothetical protein from Edwardsiella tarda revealed Proline metabolism and apoptosis in fish
Authors: Sk Injamamul Islam, Saloa Sanjida, Moslema Jahan Mou, Sarower Mahfuj, Saad Nasir
Abstract: Edwardsiella tarda is one of the most widespread pathogens in aquatic species. A wide variety of diseases can be caused by this microbe, including Edwardsiella septicaemia but clinical signs of infection differ between species of fish. The fact that the bacteria is resistant to a wide range of antimicrobials is extremely important. Furthermore, several proteins in its genome are classified as hypothetical proteins (HPs). As a result, the current work sought to elucidate the roles of an HP found in the genome of E.tarda. To determine the structure and function of this protein, many bioinformatics methods were used. To locate the homologous protein, the sequence similarity was searched across the available bioinformatics databases. Quality evaluation methods were used to predict and confirm the secondary and tertiary structure. Additionally, the active site and interacting proteins were examined using CASTp and the STRING server. An important biological activity of the HP is that it contains single functional domains that may be responsible for host-cell invasion and autolysis. Further, protein-protein interactions within selected HP revealed several functional partners that are essential for bacterial survival. One such partner is the proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase (putA) of E. tarda. In addition, molecular docking and simulation results showed stable bonding between HP and Proline metabolism protein. Finally, the current work shows that the annotated HP is associated with possible mitochondrial metabolism and autolysis formation activities, as well as having a stable binding with the putA protein, which might be of significant relevance to future bacterial genetics research.
Keywords: Hypothetical protein, molecular docking, putA protein,
autolysis, E. tarda
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