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A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin. The group led by Dr. George Georgiou developed the new antibody-production approach to improve upon processes used previously to identify new drugs for arthritis, cancer and other diseases. The new approach developed in collaboration with Dr. Brent Iverson in the Department of Chemistry and Biochemistry is faster and has other advantages.
Above photo:
Postdoctoral student Yariv Mazor (on the right), lead author of the journal article, engineered antibodies to an anthrax toxin called PA. Graduate student Thomas Van Blarcom (on the left), then used a method called APEx, co-developed by Georgiou and Iverson’s lab, to identify the bacteria-bound antibodies that attached best to the PA. Van Blarcom then grew large numbers of those bacteria to begin refining the steps needed for mass-scale production of promising therapeutic antibodies.
Fifteen biomedical engineering students from The University of Texas at Austin recently traveled to Houston to experience moments like these as part of a summer internship program at the Texas Medical Center.
The internship’s goal: give these undergrads and eight at Rice University the rare opportunity to see what it’s like to be a doctor who also conducts research. That often intense dual world is one of their career choices.
The summer program mirrors the career’s intensity, while providing an intimate knowledge of the human body, and exposure to research and to people receiving medical care. In doing so, the internship has been a career stepping stone for former participants.
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
A formula-style race car and a 1937 Chevy were among the components of a prize-winning display by a team from the Society of Automotive Engineers (SAE) student chapter at The University of Texas at Austin College of Engineering. The UT Austin team won the prestigious Honeywell Award for the second year in a row at the 2001 SAE World Congress and Exhibition in Detroit.
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A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin. The group led by Dr. George Georgiou developed the new antibody-production approach to improve upon processes used previously to identify new drugs for arthritis, cancer and other diseases. The new approach developed in collaboration with Dr. Brent Iverson in the Department of Chemistry and Biochemistry is faster and has other advantages.
Above photo:
Postdoctoral student Yariv Mazor (on the right), lead author of the journal article, engineered antibodies to an anthrax toxin called PA. Graduate student Thomas Van Blarcom (on the left), then used a method called APEx, co-developed by Georgiou and Iverson’s lab, to identify the bacteria-bound antibodies that attached best to the PA. Van Blarcom then grew large numbers of those bacteria to begin refining the steps needed for mass-scale production of promising therapeutic antibodies.
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Center for Manufacturing Excellence Technician James McPhail gives some advice on setting up a router table to a team that is putting the finishing touches on their 'Cajon', a type of African bass drum, they are building as their capstone project. Photo by Robert Jordan/Ole Miss Communications
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Yuang Guo, a masters student in environmental engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Alydia Jura, an undergraduate in mechanical engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Yuang Guo, a masters student in environmental engineering studying amidst the colors and quiet of the Courtyard between the Electrical and Engineering and Computer Science building and the George G. Brown Laboratories building on the North Campus of the University of Michigan in Ann Arbor on Wednesday afternoon, October 12, 2022.
Fall colors are taking over the campus as temperatures begin to drop.
Photo: Brenda Ahearn/University of Michigan, College of Engineering, Communications and Marketing
Kelly Morris and Katy Whitman stain the wood panels that will become the front and back of the wood and leather photo album their team is completing as their capstone project. Photo by Robert Jordan/Ole Miss Communications