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An exciting avenue for getting ideas about how a new drug might work is looking at individuals who are naturally immune or resistant to the disease. Steve Crohn lived in San Franciso in the 1970s, and lost his lover and 70 close friends to AIDS without having become infected himself. Blood tests suggested that his blood was impervious to HIV… Research found that a receptor on Steve’s blood cells called CCR2, that usually lets HIV into the cell, refused to budge – like a closed door on infection. People with mutations in the gene also showed reduced susceptibility, and a better prognosis. Importantly, Steve and others like him show no other bad effects of the mutation, suggesting that a drug that mimicked its effects would not damage other functions.
The next step is to use this knowledge to develop a drug in the ‘discovery’ phase…
This photo is a false-colour microscopy image of CCR5 receptors.
Notre-Dame de la Garde (Our Lady of the Guard), in French for Marseille’s citizens “la bonne mère” (the good (holy) mother), is a Catholic basilica in Marseille, France, and the city's best-known symbol. The site of a popular Assumption Day pilgrimage, it was the most visited site in Marseille. It was built on the foundations of an ancient fort at the highest natural point in Marseille, a 149 m (489 ft) limestone outcropping on the south side of the Old Port of Marseille.
The basilica consists of a lower church or crypt in the Romanesque style, carved from the rock, and an upper church of Neo-Byzantine style decorated with mosaics. A square 41 m (135 ft) bell tower topped by a 12.5 m (41 ft) belfry supports a monumental 11.2 m (37 ft) statue of the Madonna and Child made of copper gilded with gold leaf [Wikipedia.org]
“The Executioner” video and lighting stage for Excision, The Execution Tour 2013
Beama Visual Environments
Structural design and fabrication by Heavy Industries
Moteur :
Collecteur k-tec
Downpipe decat k-tec 2.5"
Inter tube 2.5"
Sortie grpN
Admission carbone sur mesure
Cartographie RSReprog
Rectif plénum
Support moteur renforcé k-tec
Anti couple vibra tec
Châssis :
Combiné BC Racing
Cales pentées
Magic camber Eibach
Kit gros freins 4 pistons wilwood en 300mm
Durites avia sur mesure
Pneus semis slick toyo r1r
Barre anti roulis whiteline
Oz Ultraleggera 16x7
Autres :
Demi arceau Wiechers
Barre avant/arrière Wiechers
Baquet fibre omp + harnais
Volant tulipé omp
Pont court twingo r1 14x69
Scangauge2 à la place de l'autoradio
Suppression des airbags
Suppression de la clim
Vidage complet (901kg avec la moitié du plein, le bac à casques avec 1 casque et un clé dynamométrique)
Panneaux de porte carbone
Levier de vitesse rrs + entourage carbone sur mesure