View allAll Photos Tagged RheumatoidArthritis
My wife has given her consent to my using this image of one of her Rheumatoid Arthritis treatments for this week's 'Handle With Care' theme.
Technical: this image started out as a focus stack of 15 images of the syringe on a mirror with a black background taken at f/10.0 (now that I know the sweet spot after last week's brilliant challenge!) and processed in Helicon Focus. The resulting image was then transferred to Photoshop for extensive dust-spot removal (on the mirror, not my sensor!). Back in Lightroom I applied sharpening to the whole image and a graduated filter to tone down the reflection. Finally, a radial 4-stop filter ensured the surrounding black areas were fully black!
Happy Macro Monday to everyone.
David Horace Buxton established a company in 1894
in Abbot, Maine to make his Buxton's Rheumatic Cure.
He sold his medicine to drug and general stores using
a specially constructed wagon now on display at the
Shelburne Museum.
-- Maine Memory. Net
-------------
You won't find the recipe online it is a secret formula.
Not sure if you drink it or rub It on. It is described as a
cureall so you probably drank it.
Even today there is no cure for rheumatoid arthritis
only products to make you feel better. This may have
had that effect.
-- Steve (below)
-------------
Amazing that the wagon has survived. This stuff may have contained some narcotics as well as alcohol. A lot of those vintage "miracle cures" did.
-- Curt (below)
Ribbon with a Heart.
-
I intended this piece to show solidarity with all of the "wear a ribbon to show support of the cure" causes, and I hope it will be taken as supporting the research necessary to cure all of these diseases.
I added a light pink blue, violet, and many-other colored heart to show support for all the "ribbon" causes.
The ribbon I display here is the blue and violet ribbon of Rheumatoid Arthritis, a hereditary disease that has taken its toll on my family. I have been in remission for many years, but have just come out of remission, and my physical abilities are rapidly decaying. I am seeing a specialist shortly, and maybe he will once again postpone the inevitable progression of this disease.
I can only hope. Until then I don't know how much art (or administration) I will be able to do; even my old friend the computer hurts me. I have so many unfinished projects, I may just start batch uploading them all.
One thing is sure - I have a VERY special image to celebrate the 3 month anniversary of Visual Mashups, and it WILL be there!
-----
As for this piece, it's a Special Blend - a full Compression and Diffusion - of many layers of mashups. For the heart, I blended a few of my early heart fractals, a heart from the founder of my new group Paint Creations, and flickr heart licensed under Creative Commons - derivations OK! Add to those the heart that the Great Heart of Art is based on, and then add in my own "Favoring the Heart," which is a mosaic containing 36 carefully chosen flickr favorites to make the shape of a heart.
For the ribbon, I found four standard versions of it using Google search, added a little variation to them, but also brought them together in size and angle, and blended and brightened them.
Then I montaged versions of the heart (the first version is a cut-up mosaic making up the back layer of blue) (the second version is the visible pink heart angled to the right). I then took the blue and violet ribbon, montaged it on top of the hearts, and then blended the results.
It looks particularly good in the larger sizes, the colors really burst out.
I hope you all enjoy this piece, and I hope I get to stay here working beside you for a long time.
Thanks for everything, everyone.
Arthritis Awareness is a cause very close to my heart, as I have Rheumatoid Arthritis. For many years, I believed that arthritis mainly affected older people, and was the odd twinge in the joint. That was until my auntie had it at the age of 20- it's her hand on the right hand side. I started to understand then more about how a condition such as arthritis can have a profound impact upon your life.
Then it happened to me, aged 28 and I felt like my whole world as I knew it had ended, probably because it had. My life now is utterly different from my life before, and I have swung from being housebound, to being back at work, and now I am housebound once more and using a wheelchair.
You see, there is no cure all for arthritis, and it doesn't discriminate, young, old, tall, short, slim, fat, it's an equal opportunities destroyer. The great thing is that as we progress, we learn more about this condition and how best to treat it.
If you would like to understand more about arthritis and the effect that it can have, please read this post, it's a good starting point:
batsgirl.blogspot.co.uk/2008/04/gorilla-in-your-house.html
Arthritis can't kill you, but it can take your life.
World Arthritis Day has been celebrated 1996 by ARI (Arthritis Rheumatism International) first. It is being celebrated each year on October 12th.
Now, people with arthritis from around the world join together to make their voices heard on this day. You can join in and raise this voice also!
The aims of World Arthritis Day are:
To raise awareness of arthritis in all its forms among the medical community, people with arthritis and the general public
To influence public policy by making decision-makers aware of the burden of arthritis and the steps which can be taken to ease it
To ensure all people with arthritis and their caregivers are aware of the vast support network available to them.
More info here
ummm, guys? i'm on page 14 of the current issue of arthritis today magazine.
while we're at it, go ahead and cross #11 off of the list!
today, i hurt.
walking to the subway took a little longer than usual.
i took the escalator down to the platform. normally, i take the stairs.
but tonight, my hips hurt.
the train is waiting for me. a welcome sign.
but there are no seats available.
and i am too timid and embarrassed to ask for a seat marked "disabled."
the next stop comes. someone gets up.
but a nurse is standing close to the free seat and i don't make a move.
how can i take away a seat from someone who has likely been on her feet all day?
the next stop comes. another seat opens.
but a woman a bit older than me is closer.
how can i ask someone for their seat when they look at me and see a young woman (who looks a few years younger than she actually is)?
so i stand and hold on to the pole.
my hips hurting, my heel burning.
so i hold the pole tighter.
and my fingers start to ache.
my face scrunched up in pain.
willing one of the men nearby to offer his seat.
but no one does.
my stop finally comes.
i hobble up the stairs (feeling 50 years older than i really am),
and over to the escalator.
a slow walk home.
tired, sad, fed up . . .
but i have to start the laundry.
an elderly neighbor is in the elevator when it stops on my floor.
he offers to ride to the basement to hold the door for me.
my knight in shining armor.
and he doesn't even know that i'm sick.
explore # 474
Dedicated to the memory of Gillian Ann Cox,
who finally succumbed after a very long battle
on 2nd May 2010, aged 61 years.
With love and thanks. We will all miss you.
In speaking with the nice guard outside today, he says Amgen is a laid-back place to work and the noise levels are typical for a warehouse. It is a large shipping warehouse for cancer treatment drugs. They recently expanded.
12000 Plantside Dr, Louisville, KY 40299
********
From Wikipedia - a little history:
The company has made at least five major corporate acquisitions.
Timeline
1980. William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Normam Davidson, Leroy Hood, Arnold Berk, John Carbon, Robert Schimke, Arno Motulsky, Marvin H. Caruthers, and Dave Gibson.[7]
1989. Amgen received approval for the first recombinant human erythropoetin product, Epogen, for the treatment of anemia associated with chronic kidney failure. Epogen (also marketed by Johnson and Johnson under the tradename Procrit) would later be approved for anemia due to cancer chemotherapy, anemia due to treatment with certain HIV drugs, and for the reduction of the need for transfusions associated with surgery.[8]
1991. In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy.[9] A 2002 meta-analysis found that Neupogen treatment reduced the risk of febrile neutropenia by 38%, reduced the risk of documented infection by 49%, and reduced the risk of infection-related mortality by 40%.[10]
1998. In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha).[8] A 2006 assessment by the National Institute of Clinical Excellence of the United Kingdom concluded that etanercept and related rheumatoid arthritis drugs later introduced by competitors "are effective treatments compared with placebo for RA patients who are not well controlled by conventional DMARDs, improving control of symptoms, improving physical function, and slowing radiographic changes in joints."[11] A more recent study demonstrated that compared to traditional disease-modifying anti-rheumatic drugs, treatment with etanercept improved survival, reduced cardiovascular events and reduced the incidence of hematological cancers.[12]
2010. On June 6, 2010 Amgen received FDA approval for Prolia, a protein drug for the treatment of post-menopausal osteoporosis.[13] In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%.[14]
2010 In November 2010 the FDA approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors.[15] The clinical trials primarily enrolled patients with breast or prostate cancer.
2012. Illegal marketing practices. The Los Angeles Times reported on December 18, 2012, that AMGEN pleaded guilty and agreed to pay $150 million in criminal penalty and $612 million to resolve 11 related whistleblower complaints. Federal prosecutors accused the company of pursuing profits while putting patients at risk.[16] Larry Husten, a contributor at Forbes.com elaborates on AMGEN's illegal marketing practices in this case, namely that the "government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices".[17] One of the drugs mentioned in the lawsuit had sales of $492 million in the third quarter of 2012, down 17% from the same quarter the previous year due to "reimbursement problems and label changes".[18]
2012. Amgen paid $762 million after pleading guilty to criminal charges of improper promotion and sale of misbranded drugs.[19]
2013. Lawmakers inserted text into the fiscal cliff bill that will allow the drugmaker to sell a class of drugs that includes Sensipar without government controls for an additional two years. The New York Times estimated that the paragraph in the fiscal cliff bill will cost taxpayers an estimated $500 million[20] but other assessments concluded that the change would protect seniors in rural areas and reduce overall Medicare spending.[21][22]
2015. In September the company announced it would acquire Dezima Pharma for more than $1.55 billion.[23] The same day the company announced a collaboration with Xencor on 6 early stage immuno-oncology and inflammation programmes. As part of the deal Amgen will pay $45 million upfront, with the deal being worth up to another $1.7 billion.[24][25]
2016. In September, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma.[26]
*******************
From the Wall Street Journal 5/29/21: A pathbreaking pill for lung cancer from Amgen Inc. was approved by the U.S. Food and Drug Administration, adding a new potential blockbuster to the biotech giant’s aging stable of drugs.
The drug, called Lumakras, was approved Friday to treat a portion of lung cancer patients with a particular genetic mutation who have already tried other therapies.
The mutation, known as KRAS, is among the most common found in cancers, but researchers struggled for so many years to find a medicine that can treat it that the mutation came to be considered “undruggable.”
Amgen Wins Approval for Pathbreaking Lung Cancer Drug (By Joseph Walker
Updated May 28, 2021 3:42 pm ET): www.wsj.com/articles/amgen-wins-approval-for-pathbreaking...
***********
It is ironic that stem-cell treatment is used in other Nations successfully in combating cancer, yet not in the USA.
Toronto, Canda. Hydroxychloroquine, prescription for Lupus or Rheumatoid Arthritis, being pushed by Donald Trump as a possible drug to combat #Covid19, with no evidence © Linda Dawn Hammond/ IndyFoto April 19, 2020.
After Christmas I started to get pain in my jaw but I have wisdom teeth forming so I was used to it. I started to sleep on my back to avoid sleeping on my face at night making things worse. I started to complain about pain in my legs and shoulders which I just put down to sleeping funny.
As time passed (a month or so) the pain and stiffness in my legs and arms got worse and I was having trouble getting up out of chairs/bed and walking was even slow at times.
I then started to get pins and needles in my hands and wrists which I thought was just RSI because I am always on a computer or playing xbox.
After 2 months we thought I should see a doctor as things really weren't improving and were clearly getting worse. I was ordered to have some blood tests which revealed I had some issues with inflammatory arthritis. It sounded insane as I am so young but its not unheard of.
With a lot more blood tests and an X-ray on my hands which by now had pretty much swollen and one was nearly unusable I was referred to a Rheumatologist.
I was told it would be a 6-9 month wait, but within 3 months i got a call for an appointment which seemed odd. I saw the specialist who confirmed that I have Rheumatoid Arthritis (RA).
I have it pretty bad, almost in every joint. Its rare in men and that's why I was called in so fast after they saw my blood tests. Finally I was being listened to and getting the help I need. Right there and then they drained fluid from both my knees and injected me with a steroid.
If you treat RA aggressively within the first year of it showing up there is a chance of it going into remission for a while before surfacing at older age. Seeing that I am so young they want to try and give some quality of life back before I have to deal with old age. So my treatment will be weekly injections in my arm and pills to be taken daily, physio and sessions in the pool.
Its going to be intense but by the end of that day the steroid had already started to work wonders and over the weekend I could now open jars, dress myself and walk up stairs with no problem. I am in the best care now and I am 30lbs lighter as well because all the stress caused me to lose weight.
Its been a shit 5 months but finally I am getting some relief, I am not cured but I am being treated by the right people.
So I am back, oh and in that time I became a Canadian permanent resident YAY!
Did you miss me?
Joint tissue from patients with rheumatoid arthritis (RA) contains high numbers
of B cells (white), the antibody-producing cells of the immune system. These cells produce high levels of the signaling molecule RANKL (green), which stimulate osteoclasts (red), causing bone to break down. Researchers aim to identify the specific B cell subsets and molecular pathways involved in the cells’ harmful effects so that they can find ways to target them selectively. The ultimate goal is to develop new RA treatments with fewer unwanted side effects.
Credit: Jennifer Anolik, M.D., Ph.D., University of Rochester
Funded by: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
I absolutely hate having to take all this shit!
I mostly don't.
I mostly pretend I am not ill.
I mostly can't be bothered to make up a weeks-worth.
But it's useful when done.
Mostly I take them, but periodically I can't be bothered to.
Then everything starts to hurt and I take them all again.
This is the reality of my life. Rheumatoid Arthritis. I've been diagnosed with it for about 5 years now. It was the second autoimmune disease that was discovered (the first being Hasimoto's Disease of the thyroid). They don't really know what triggers RA, all they've told me is that it's there in your DNA and something kickstarts it, like a bad cold. I do remember getting a really bad flu while I was living in the UK about a year before I noticed everything start, so maybe that was it. All I know is that my body hates me. My immune system doesn't function the way it should, it attacks my body because it can't distinguish between what's "me" and what's foreign - as far as my blood cells are concerned they're fighting the good fight, preventing my body from getting sick, but boy do they have it wrong!
At first I was half convinced they'd diagnosed me wrong, I barely had any symptoms, and then when things became apparent it was well managed by medications as it'd been caught early on.
But it seems my body too readily adjusts with medications. What was once effective suddenly doesn't cut the mustard anymore. When I left for my lengthy holiday in Canada I was feeling the best I had in years, but during the duration of my stay everything reversed itself. I wasn't getting the specialist treatment I needed and things got out of control. And it was certainly a shock to the system I can tell you. There were days that it was agony to get out of bed and put my feet on the floor. I just couldn't stand up. Getting up from a seat would take me numerous attempts and lots of psyching myself up, dependent on armrests to pull myself up. I was having trouble with everyday activities. Getting dressed and brushing my hair was sometimes a chore. I'd have to take stairs one at a time. Forget about going faster than a snail's pace when walking. Opening a jar? Forget it!
All those little things that people take for granted. And I hated having to ask people to help me. I tried to hide it from people as much as I could, didn't want them to know the extent of how bad things were. I hated feeling like a cripple and being dependent on someone else. I hated not being able to join in fun things that other people would organise. Even now I'm amazed at the support and patience of my ex-boyfriend as he helped me through this time when I was away from home and not sure how to cope with it all, even though I tried to hide it as much as possible from him too because I didn't want him to get frustrated with me.
It took me over a year of specialist 'attention' to get to the stage where I could even think about starting to work again once I arrived back home in Australia. I say attention loosely as I'd only ever see the specialist once every 3 months or so as she monitored my progress with different medications - hmmm, that one isn't doing what we'd like it to, so let's gradually take you off that and start you on this and see how we go.... that one doesn't work? Making you feel sick with all the side effects? Ok, we'll put you on this one, but before you can start that you'll need to go on a trial of this drug and see if you meet the requirements necessary to start this particular treatment.
But finally we've found something that's doing the best of them so far. Things still aren't 100%, and there's all the inevitable side effects to deal with, but it's a very far cry from where I started! I can now bend my knees and have a full grip (before i could only half close my fist because the swelling on my joints was so very bad), i can move without pain and the swelling has gone down. My energy levels might still wax and wane, but I can actually go out and do things and not get too tired and sore and don't need to spend the next day suffering from my 'excess'.
But it's a bit of a love/hate relationship with the medication that allows me this new freedom. I expect that diabetics are in much the same boat. Injections. And I HATE NEEDLES!!!! It's only once a fortnight, but I face the day of the injection with much dread. My father was talking to a friend that's a diabetic and he said that as it's a daily ritual for him he's completely used to it and can do it in a flash, but he felt that if he was in my situation when there is as long a break inbetween doses he'd be as traumatised as I feel. It's self-administered, but ever since the first time I did it and almost blacked out I always make sure that someone's there with me when I do it. In the end that person (my father) has become the person to push the needle because he was getting too frustrated with me psyching myself up to do it! The button to press to inject the med is quite stiff, and each time I'd pace my breathing and press down on it I'd find out that I didn't actually manage to do it and would have to start the whole process again. Call me a coward, but as I said I HATE needles, and the anticipation of the pain is just as bad as the pain itself!
But this is pretty much the story of my life from here on in. RA is for life. It's just a matter of managing it and not allowing it to progress and cause disfigurement. So far I've been lucky on that score, although my joints have little 'nibbles' in them that will never heal. I've heard various reports in the papers about Australian and UK research that says they've found a cure, but I'll believe that when I see it! I personally would be surprised if the pharmaceutical companies would allow such a thing to go on sale when they can make so much money on drugs to manage the disease. And trust me, there's a LOT of money in managing this condition! You'd be shocked how much just a single injection costs!
But still I'll live in hope that one day I won't need to do these hated injections ever again!
sara
new york city
diagnosed with rheumatoid arthritis at age 29
******
sara is the voice behind the single gal's guide to rheumatoid arthritis and the organizer of our recent sick chick club meet-ups in nyc.
she is such a terrific person, great friend and amazing advocate for people with RA and other autoimmune diseases. i am so happy to have met her! sadly (for me, at least), she is soon moving to baltimore. i know it's going to be great for her, but i'll miss my new friend!
this is the beginning of a project i am working on. my plan is to do a portrait series of people with autoimmune diseases (rheumatoid arthritis, lupus, ankylosing spondylitis, fibromyalgia, celiac disease, hashimoto's disease, etc.). often, these diseases strike people at a young age and are chronic. we don't usually look sick, but they never really go away. there are so many people out there who are struggling with these health issues, and the general public doesn't really understand. i want to give a face to these diseases to inform my friends and family at least, and the world at best, that we really aren't "too young to have that" and that even though we "don't look sick," we are. and we need your care and support.
with that, if any one wants to volunteer for a portrait session or has a friend or family member who might be interested, please flickr mail me or e-mail me at jodimckeephotography@gmail.com. thanks!!
This is me injecting Enbrel into the skin on my stomach. This drug is taken once a week for my rheumatoid arthritis. You can either inject it in your thigh or your stomach. I prefer my stomach.
FDA is strengthening an existing warning on some prescription and over-the-counter (OTC) drug labels to indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the chance of a heart attack, stroke, and death. To learn more, read the FDA Consumer Update.
This graphic is free of all copyright restrictions and available for use and redistribution without permission. Credit to the U.S. Food and Drug Administration is appreciated but not required. For more privacy and use information visit: www.flickr.com/people/fdaphotos/
FDA graphic by Michael J. Ermarth
For the more than 2.1 million Americans affected by rheumatoid arthritis, there is encouraging news about how antibiotic therapy can be a safe, low-cost way to manage many of the symptoms of the disease.
Rheumatoid arthritis causes pain, stiffness, warmth, redness and swelling, affecting many...
healthsame.com/arthritis/encouraging-news-rheumatoid-arth...
What is Arthritis?
Arthritis literally means “joint inflammation” and can affect joints in any part of the body. A joint is where two or more bones come together such as the knee, shoulder or wrist. Healthy joints are covered with a sponge-like material known as cartilage. The joint...
Patient has rheumatoid arthritis, treated with corticosteroids, leflunomide, and methotrexate. Fungal cultures are pending. I was able to find a lab that does an immunoperoxidase stain for Coccidioides on the bloc, also pending.
One in three adult Americans suffer from some form of arthritis and the disease affects about twice as many women as men.
Arthritic diseases include rheumatoid arthritis and psoriatic arthritis, which are autoimmune diseases; septic arthritis, caused by joint infection; and the more common...
In the immune system, T helper cells stimulate B cells to produce antibodies that fight potential disease-causing infections. In people with rheumatoid arthritis (RA), however, B cells produce autoantibodies that attack the body’s own healthy tissues. Researchers have identified a specific type of T helper cells, called T peripheral helper (Tph) cells (stained blue). These cells stimulate B cells (green) to produce autoantibodies in the joints of people with RA. Understanding this mechanism may help scientists develop new treatment targets for the disease.
Photographer: Michael B. Brenner, M.D., and Deepak Rao, M.D., Ph.D., Brigham and Women’s Hospital, Boston.
If your pet has been diagnosed with arthritis you might find Green-lipped mussel (Perna canaliculus) is included in some glucosamine based treatments. Green lipped mussel has been found to inhibit inflammation in the joints and is useful in the treatment of rheumatoid arthritis and...
healthsame.com/arthritis/green-lipped-mussel-extract-trea...
The treatment options for rheumatoid arthritis has come a long way. From medications to therapies to immune system modulators, there are options available aplenty to get rid of the pain and discomfort caused due to this ailment. Read out more about how you can soothe your inflamed joints and muscles with the help of an apt solution if you are suffering from rheumatoid arthritis…https://hcah.in/health-advantage/treatments-for-rheumatoid-arthritis-at-home/
Arthritis, which is a condition that affects one in three adult Americans, is one that affects the bone joints in the body. Because there is no cure, many sufferers are forced to cope with it’s painful effects. Arthritis in the knee is one of the common ailments and can make it difficult...
Introduction
Arthritis is a general term which is applied to a number of painful conditions affecting the joints and bones. There are about 100 different types of arthritis.
Arthritis is normally associated with older people, but it can affect people at any age, even children. This is called...
For those suffering from arthritis in the spine, palindromic arthritis, viral arthritis, and/or cervical arthritis, coping techniques are simply not the answer. Lumbar arthritis, shoulder arthritis, viral arthritis, and/or psoriasis arthritis sufferers, for example, desire permanent arthritis...
Rheumatoid Arthritis, also known as “RA” is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. It is a disabling and painful inflammatory condition, which can lead to substantial loss of mobility due to pain and joint destruction. The...
This photograph shows a Sequenom chip after it has been in the nanodispenser and loaded with single nucleotide polymorphism (SNP) samples from an assay plate. The SNP genotyping system is being used to try to identify genetic factors that would increase susceptibility to rheumatoid arthritis using specimens from people with rheumatoid arthritis and specimens from controls. The principal investigator for this work was Daniel L. Kastner, M.D., Ph.D., who was the NIAMS Clinical Director and Chief of the Genetics and Genomics Branch when the photo was taken.
Photographer: Rhoda Baer
This photograph shows multiple assay plates containing single nucleotide polymorphism (SNP) assay products produced from DNA obtained from people with rheumatoid arthritis and from controls in a mixer. These samples are mixed before the assay plates are loaded into the nanodispenser which then transfers a small amount of the SNP sample onto a chip to be read by the mass spectrometry system, a part of the high throughput SNP genotyping system. The purpose of this research is to identify genetic factors that would increase susceptibility to rheumatoid arthritis. The principal investigator for this work was Daniel L. Kastner, M.D., Ph.D., who was the NIAMS Clinical Director and Chief of the Genetics and Genomics Branch when the photo was taken.
Photographer: Rhoda Baer