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El MUNCYT acoge Big Neurona, un museo móvil interactivo con forma de neurona gigante. Esta instalación ha sido inaugurada por el alcalde de A Coruña, Don Xulio Ferreiro. Big Neurona es un laberinto de espejos en el que se muestran las diferentes partes que componen las neuronas y se realizan juegos y otras actividades. Estará abierta al público desde el 22 de enero al 26 de junio
Excitatory pyramidal neurons from mouse visual cortex.
Render by Amy Sterling from
reconstructions by Seung Lab, Princeton Neuroscience Institute using images acquired by The Allen Institute. Funded by IARPA MICrONS. Rendered in Cinema 4D using Otoy Octane GPU renderer.
An example of a brain cell I was able to cause to fluoresce. There are actually 4 cell-bodies in this image capture of a mouse brain.
This in vivo 2-photon image was created using viral vectors from the viral gene transfer core, a facility established in 2008 by the Picower Institute and the McGovern Institute to make viral vectors accessible to the MIT neuroscience community.
Image courtesy of Sam Clark, McGovern Institute for Brain Research at MIT
With this image, I wanted to show how magnificent and intriguing are the elementary processing units of the mammalian central nervous system. The image shows three "Layer 5 pyramidal neurons" visualized ex-vivo, in a coronal slice from the mouse brain containing the primary visual cortex. The unique morphology of these neurons is revealed by a fluorescent dye (Alex 594) injected into each cell via a patch clamp pipette (seen on the bottom-right corner of each neuron) and excited with a 820nm two photon laser. I found this image significant and interesting for the “Discovery Channel” theme because the morphology of pyramidal neurons, mostly characterized by the several dendrite branches ramifying from the cell body, is revealed after the combined use of the patch clamp technique and laser-scanning fluorescence microscopy. Indeed, the precise manipulation of the micropipette under the microscope allowed to inject the fluorescent dye in each neuron while keeping them alive for further experimental use. Strikingly, the cellular morphology tell us a lot about the function of pyramidal neurons, that - as a TV antenna does - continuously receive and compute information in the brain.
Alex Moreau
Image: E18 hippocampal neurons stained with MAPT (red) and Doublecortin (green). The two proteins overlap in the proximal dendrites, but doublecortin is more abundant in the growth cones and periphery. As a result, the periphery appears green while the more proximal regions of the cells are yellow. The single longer process of this cell, presumably an axon, has a low doublecortin content and so appears red. Blue staining is the nuclear DNA. Protocol on datasheet.
Part of a series of illustrations created for UC San Francisco to illustrate their work on the role of neurons in regulating thirst. This image shows a neuron made of water.
Tyrosine Hydroxylase Immunostaining in Substantia Nigra. NIKON E600 light microscope. This microphotograph appeared at FAPESP journal in February, 2007.
Synapse trio between excitatory neurons of mouse visual cortex.
Render by Amy Sterling from
reconstructions by Seung Lab, Princeton Neuroscience Institute using images acquired by The Allen Institute. Funded by IARPA MICrONS. Rendered in Cinema 4D using Otoy Octane GPU renderer.
Part of a series of illustrations created for UC San Francisco to illustrate their work on the role of neurons in regulating thirst. This image shows a coronal splash, but with the tips morphing into neurons.
*Neuroni Specchio*
"L’uomo piglia a materia anche se stesso, e si costruisce, sissignori, come una casa. Voi credete di conoscervi se non vi costruite in qualche modo?E ch’io possa conoscervi se non vi costruisco a modo mio?E voi me, se non mi costruite a modo vostro?Possiamo conoscere soltanto quello a cui riusciamo a dar forma. Ma che conoscenza può essere?E’ forse questa forma la cosa stessa?Sì, tanto per me, quanto per voi.;ma non così per me come per voi: tanto vero che io non mi riconosco nella forma che mi date voi, né voi in quella che vi do io; e la stessa cosa non è uguale per tutti e anche per ciascuno di noi può di continuo cangiare, e difatti cangia di continuo. Eppure, non c’è altra realtà fuori di questa, se non cioè nella forma momentanea che riusciamo a dare a noi stessi, agli altri, alle cose. La realtà che ho io per voi è nella forma che voi mi date; ma è realtà per voi e non per me; la realtà che voi avete per me è nella forma che io vi do; ma è realtà per me e non per voi; e per me stesso io non ho altra realtà se non nella forma che riesco a darmi. E come? Ma costruendomi, appunto”
Luigi Pirandello – Uno, nessuno e centomila
www.culturalismi.com/culturalismi/la-vignetta-del-mese/un...