View allAll Photos Tagged Neurology
@tokyo
*Graflex Speed Graphics+Ektar 127mm f4.7+AgfaCT 120film(6x9)
*Viewing in LARGE SIZE is definitely the best!!
Illustration of the neurological connections in the brain controlling speech production.
Credit: Stefan Fuertinger and Kristina Simonyan, Icahn School of Medicine at Mount Sinai
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
NIH support from: National Institute on Deafness and other Communication Disorders
Brain medicine mental health care concept as hands holding an open pill capsule releasing gears to a human head made of machine cog wheels as a symbol for the pharmaceutical science of neurology and the treatment of psychological illness.
Neurologically Operated Robotic Automoton, or N.O.R.A. was meant to be Victor's solution to both preserving his beloved wife, and allowing her to continue to function in the world while he could focus on finding her a cure. Only the years as a human snow cone and constant battles Batman have not been kind to Nora. While technically still alive, her body and mind have suffered extensive tissue damage, and she can no longer control N.O.R.A. Instead Victor has taken over the controls. Now outfitted with a mammoth freeze cannon, hurling pissed off polar bears, and a doomsday failsafe that will trigger a cataclysmic nuclear winter, N.O.R.A. Will become the vehicle of Victor's ultimate revenge against Batman and a world whose heart has grown cold.
My entry for FBTB's Mech Madness 2012
HAPPY EASTER to Those that Celebrate. I personally don't but, I respectfully appreciate that it is important to some people and so would like to wish those that do, a very pleasant and peaceful day wherever you are in the world :-)
Phoenix 200 iso 35mm Film
Harman Technology
Fujica ST605N
Fujinon 55mm 1:2.2
Inbuilt light meter
f4 1/700
Home developed with Bellini C41 Kit.
No Crop, No filter, No Post production.
PS. I didn't put the snail shell on the cross. haha. It was absolutely just sitting there, bang smack in the middle of it. Unfortunately, it was deceased upon further inspection *awkward*. And my eyes missed manual focusing on the snail as the focal point. Never mind.
I pretty much always use manual focusing on all my lenses. Always have. Habit and how I like it. I have been lucky enough to do so with my eyesight again recently without issues after a few years unable to due to a neurological problem causing vision issues. So it means the absolute world to me to be able to see the world like this again and enjoy my long loved passion. Never take your vision for granted! And enjoy every single moment you have it. It is soooo precious.
:-D
I spent yesterday taking Janice to the neurologist for her routine exam, and then my dad to an orthopedist, to plan for knee surgery. Fortunately, I had my point-and-shoot! Here are some objects on the table in the first exam room.
*** EXCLUSIVE - VIDEO AVAILABLE *** BIRMINGHAM, UNITED KINGDOM - SEPTEMBER 13: Jody Robson, who believes she has Kleine Levin Syndrome, is pictured asleep, on September 13, 2015, in Birmingham, England. A MOTHER has no recollection of the birth of her first born because she was ASLEEP. Jody Robson, 24, from Birmingham, falls asleep for up to 11 days at a time and can take weeks to emerge from her stupor. Although she has not been formally diagnosed, Jody believes she has Kleine Levin Syndrome, a rare neurological disorder that sees those afflicted unable to rouse from sleep for days or even weeks on end. Jodyís episodes are so severe that she has no recollection of several Christmases and even slept through the birth of her first child. PHOTOGRAPH BY Nick Cunard / Barcroft Media UK Office, London. T +44 845 370 2233 W www.barcroftmedia.com USA Office, New York City. T +1 212 796 2458 W www.barcroftusa.com Indian Office, Delhi. T +91 11 4053 2429 W www.barcroftindia.com
The last remaining Ravenswood abandoned hospital is finally being rehabbed. Work started recently to make this old hospital into new retirement senior living, apartments will be made into supportive living. Before it closed, this building of the hospital was being used for Neurologic and Orthopedic spinal and brain care. I was born in Ravenswood hospital in the section that was demolished and turned into a french school. Lycee Francais
UCL Institute of Neurology, Queen Square, London WC1. Completed 1978.
Sony A7 + Canon FD 35mm f/2.0 SSC.
History
Thalidomide was created by Grünenthal in 1953 and was used in the late 1950s and early 1960s as a "wonder drug" to treat morning sickness, headaches, coughs, insomnia and colds. Thalidomide was marketed in the UK under the name Distaval in 1958, and advertisements emphasized the drug's complete safety, using phrases such as “non-toxic” and “no known toxicity”.
However, in 1961 an Australian doctor, William McBride, wrote to the Lancet after noticing an increase in deformed babies being born at his hospital – all to mothers who had taken Thalidomide.
Between 1958 and 1962 tens of thousands of women throughout Europe found that the baby they were carrying unaccountably miscarried, or, worse, after they gave birth were told it was stillborn. Thousands more discovered that their babies had severe birth defects, missing arms, legs, or with severe reductions to these limbs, or even worse, damage to their internal organs, brain, heart, kidneys, intestines, genitals, etc. During 1962 record keepers began to count all of the children living who were born damaged by the drug. The only complete records are of those who survived long enough to participate in the national compensation schemes, which were established in Germany, Britain, Japan, Sweden and Australia in the 1970s. The difficulty in uncovering the full toll of the disaster begins with the unknown numbers of miscarriages and stillbirths (possibly up to ten times the number of live births), and the widespread practice of infanticide.
The Thalidomide injuries did not stop once the babies were born. At the age of fifty, the Thalidomide Trust’s records show that around half of all survivors are coping with chronic pain – mainly from muscles and joints (musculo-skeletal pain), largely as a result of the challenges of living with missing or damaged limbs. For many, their bodies are deteriorating far faster than able-bodied people. Several have been told words to the effect “your body is getting the problems of someone in their seventies”, which at forty to fifty years of age is not good news. At least a quarter are coping with developing neurological problems, tingling, numbness, and pain in their affected limbs. This means that a person may be holding a cup, for instance, and the next thing they know is it has fallen to the floor and broken, because of the numbness in their hand. For these survivors, the disaster is still slowly unfolding in their day-to-day lives.
Grünenthal scientists were not only negligent in failing to withdraw the drug when reports of problems came in, or for failing to test it according to the standards of the time, but more than most companies they were very well placed to anticipate the possibility that Thalidomide would cause birth defects.
Grünenthal initially denied claims that the drug hadn’t been extensively tested according to the standards of the time, but once the scandal became undeniable, they sought to deflect blame and limit damage.
In 1961 Thalidomide was eventually withdrawn after being found to be a teratogan - a cause of birth defects. 12 years later, the UK company Distillers Biochemicals Limited (now Diageo) – which was responsible for distributing the drug in the UK – reached a compensation settlement following a legal battle by the families of those affected.
Based on incomplete medical evidence and unrealistic expectations of Thalidomide survivors future needs this settlement has turned out to be at an inadequate level. With all Thalidomide survivors in the UK now over the age of 50, it is no longer sufficient to deal with their rising cost of living, and the dramatic deterioration of their health.
To this day, Grünenthal have never accepted responsibility for the suffering caused by Thalidomide. On September 1st 2012, The Grünenthal Group released a statement containing an apology, stating that it "regrets" the consequences of the drug, which led to babies being born without limbs during the 1950s and 1960s. Although the statement was welcomed by some Thalidomide survivors, it is still not an acceptance of responsibility. They just want to live a comfortable life, and that means Grünenthal should be held accountable and pay for their mistake financially.
Spanish
Historia
La talidomida fue creado por Grünenthal en 1953 y fue utilizado a finales de 1950 y principios de 1960 como una "droga milagrosa" para el tratamiento de las náuseas, dolores de cabeza, tos, insomnio y resfriados. La talidomida fue comercializada en el Reino Unido bajo el nombre Distaval en 1958, y destacó los anuncios de seguridad completa del medicamento, utilizando frases como "no tóxico" y "no hay toxicidad conocida".
Sin embargo, en 1961 un médico australiano, William McBride, escribió a la revista The Lancet después de notar un aumento en los bebés que nacen deformes en su hospital - todo a las madres que habían tomado Talidomida.
Entre 1958 y 1962, decenas de miles de mujeres de toda Europa descubrieron que el bebé que llevaban inexplicablemente abortado, o, peor aún, después de dar a luz se les dijo que estaba muerto. Miles de personas descubrieron que sus bebés nacieron con defectos congénitos graves, los brazos, las piernas, que faltan o con reducciones severas a estos miembros, o peor aún, el daño a sus órganos internos, cerebro, corazón, riñones, intestinos, genitales, etc Durante 1962 guardianes de los registros empezó a contar toda la vida los niños que nacieron dañado por la droga. Los únicos registros completos son de los que sobrevivieron lo suficiente como para participar en los sistemas nacionales de indemnización, que se establecieron en Alemania, Gran Bretaña, Japón, Suecia y Australia en la década de 1970. La dificultad para descubrir el número de víctimas del desastre comienza con los números desconocidos de abortos involuntarios y mortinatos (posiblemente hasta diez veces el número de nacidos vivos), y la práctica generalizada del infanticidio.
Las lesiones de la talidomida no se detuvo una vez que los bebés nacieron. A la edad de cincuenta años, los registros de la confianza talidomida muestran que cerca de la mitad de todos los sobrevivientes están lidiando con el dolor crónico - principalmente de músculos y articulaciones (dolor musculoesquelético), en gran parte como resultado de los desafíos de vivir con la falta o ramas dañadas. Para muchos, sus cuerpos se deterioran mucho más rápido que las personas sanas. Algunos han dicho palabras en el sentido de "su cuerpo está recibiendo los problemas de alguien en los setenta", que a los cuarenta o cincuenta años de edad no es una buena noticia. Al menos una cuarta están lidiando con el desarrollo de problemas neurológicos, hormigueo, entumecimiento y dolor en las extremidades afectadas. Esto significa que una persona puede ser la celebración de una taza, por ejemplo, y lo siguiente que sé es que ha caído al suelo y se rompe, debido a la sensación de adormecimiento en la mano. Para estos sobrevivientes, el desastre está siendo poco a poco se desarrolla en su día a día.
Grünenthal científicos no sólo fueron negligentes al no haber retirado la droga cuando los informes de problemas de vino, o por no probarlo de acuerdo a los estándares de la época, pero más que la mayoría de las empresas que estaban muy bien situados para prever la posibilidad de que la talidomida haría causar defectos de nacimiento.
Grünenthal inicialmente negó las acusaciones de que el medicamento no ha sido ampliamente probado de acuerdo con los estándares de la época, pero una vez que el escándalo se hizo innegable, trataron de desviar la culpa y limitar el daño.
En 1961, la talidomida fue finalmente retirada después de haber sido encontrado para ser un teratogan - una de las causas de los defectos congénitos. 12 años después, el Reino Unido, Distillers Company Limited (ahora Bioquímicos Diageo) - encargada de la distribución de la droga en el Reino Unido - llegó a un acuerdo de compensación después de una batalla legal por las familias de los afectados.
Sobre la base de evidencia incompleta médica y expectativas poco realistas de la talidomida futuro sobrevivientes necesita esta solución ha resultado ser en un nivel adecuado. Con todos los sobrevivientes de la talidomida en el Reino Unido ahora más de 50 años de edad, ya no es suficiente para hacer frente a su creciente costo de vida, y el dramático deterioro de su salud.
A día de hoy, Grünenthal nunca ha aceptado la responsabilidad por el sufrimiento causado por la talidomida. El 1 de septiembre de 2012, el Grupo Grünenthal emitió una declaración que contenga una disculpa, diciendo que "lamenta" las consecuencias de la droga, lo que llevó a los bebés que nacen sin extremidades durante los años 1950 y 1960. Aunque la declaración fue bien recibida por algunos sobrevivientes de la talidomida, no es todavía una aceptación de responsabilidad. Ellos sólo quieren vivir una vida cómoda, y eso quiere decir Grünenthal deben rendir cuentas y pagar por su error financieramente.
Italian
Storia
La talidomide è stato creato da Grünenthal nel 1953 ed è stato utilizzato alla fine del 1950 e 1960 come un "farmaco miracoloso" per curare la malattia di mattina, mal di testa, tosse, insonnia e raffreddori. La talidomide è stato commercializzato nel Regno Unito con il nome di Distaval nel 1958, e la pubblicità ha sottolineato sicurezza del farmaco, con frasi come "non tossico" e "nessuna tossicità conosciuto".
Tuttavia, nel 1961 un medico australiano, William McBride, ha scritto al Lancet dopo aver notato un aumento delle nascite di bimbi malformati essendo nati a suo ospedale - tutti da madri che avevano assunto talidomide.
Tra il 1958 e il 1962 decine di migliaia di donne in tutta Europa ha scoperto che il bambino che portavano inspiegabilmente abortito, o, peggio, dopo che ha dato alla luce hanno detto che era morto. Altre migliaia hanno scoperto che i loro bambini hanno gravi difetti di nascita, braccia, gambe, mancanti o con gravi riduzioni a queste arti, o peggio ancora, danni ai loro organi interni, cervello, cuore, reni, intestino, genitali, ecc Nel 1962 custodi record cominciò a contare tutta la vita i bambini che sono nati danneggiati dal farmaco. Le uniche registrazioni complete sono di coloro che sono sopravvissuti abbastanza a lungo per partecipare ai sistemi di indennizzo nazionali, che sono stati stabiliti in Germania, Gran Bretagna, Giappone, Svezia e Australia nel 1970. La difficoltà nello scoprire il bilancio del disastro inizia con i numeri sconosciuti di aborti spontanei e nati morti (forse fino a dieci volte il numero di nati vivi), e la pratica diffusa di infanticidio.
Le lesioni Talidomide non si è fermata una volta che i bambini sono nati. All'età di 50, del Trust talidomide i tabulati mostrano che circa la metà di tutti i sopravvissuti stanno affrontando con dolore cronico - principalmente da muscoli e le articolazioni (il dolore muscoloscheletrico), soprattutto a causa delle sfide della vita con mancanti o arti danneggiati. Per molti, i loro corpi si stanno deteriorando molto più veloce di persone abili. Molti hanno detto parole per l'effetto "il tuo corpo è sempre il problema di qualcuno nei loro anni settanta", che a 40-50 anni di età non è una buona notizia. Almeno un quarto stanno affrontando con lo sviluppo di problemi neurologici, formicolio, intorpidimento e dolore a carico degli arti colpiti. Ciò significa che una persona può essere in possesso di un tazza, per esempio, e la prossima cosa che so è che è caduto a terra e rotto, a causa del torpore in mano. Per questi sopravvissuti, il disastro è ancora lentamente svolgendo nel loro giorno per giorno la vita.
Grünenthal scienziati non erano solo negligenza nel non ritirare il farmaco quando i report di problemi è venuto in, o per non aver testarlo secondo gli standard del tempo, ma più che la maggior parte delle aziende erano molto ben disposti ad anticipare la possibilità che Thalidomide avrebbe causare difetti di nascita.
Grünenthal inizialmente smentito che il farmaco non era stato ampiamente testati secondo gli standard del tempo, ma una volta che lo scandalo è diventata innegabile, hanno cercato di deviare la colpa e di limitare i danni.
Nel 1961 talidomide è stata infine ritirata dopo essere stato trovato per essere un teratogan - una causa di difetti di nascita. 12 anni dopo, i Distillers Company Limited, Regno Unito Biochemicals (ora Diageo) - incaricata di distribuire il farmaco nel Regno Unito - ha raggiunto un accordo di compensazione a seguito di una battaglia legale da parte delle famiglie delle persone colpite.
Sulla base di prove mediche incomplete e le aspettative non realistiche del futuro Thalidomide sopravvissuti ha bisogno di questa soluzione si è rivelata essere ad un livello insufficiente. Con tutti i sopravvissuti Talidomide nel Regno Unito ora di età superiore ai 50 anni, non è più sufficiente per affrontare la loro crescente costo della vita, e il drammatico deterioramento della loro salute.
Fino ad oggi, la Grünenthal non hanno mai accettato la responsabilità per la sofferenza causata dal talidomide. Il 1 ° settembre 2012, il Gruppo Grünenthal ha rilasciato una dichiarazione che contiene delle scuse, affermando che esso "deplora" le conseguenze della droga, che ha portato a bambini nati senza arti nel corso del 1950 e 1960. Anche se la dichiarazione è stata accolta da alcuni sopravvissuti talidomide, non è ancora una assunzione di responsabilità. Vogliono solo vivere una vita comoda, e questo significa che Grünenthal dovrebbero essere ritenuti responsabili e pagare per il loro errore finanziario.
Japanese
サリドマイドは1953年にGrünenthalによって作成されたとつわり、頭痛、咳、不眠や風邪を治療するための「特効薬」として、1950年代後半から1960年代初頭に使用された。サリドマイドは1958年に名称Distavalの下に英国で販売された、と広告はそのような「非毒性」と「知られていない毒性」などのフレーズを使用して、薬剤の完全な安全性を強調した。
サリドマイドを取っていた母親にすべて - しかし、1961年にオーストラリアの医師、ウィリアム·マクブライドは、彼の病院で生まれた赤ちゃん変形の増加に気付いた後、Lancet誌に手紙を書いた。
1958と1962の間で十ヨーロッパ全土の女性の何千人もの彼らは誕生それは死産だったと言われたた後に、彼らがどういうわけか運んでいた赤ちゃんが、悪化し流産し、またはことがわかった。もっと自分の赤ちゃんは1962レコードキーパーの間に脚、またはなど彼らの内臓、脳、心臓、腎臓、腸、生殖器、これらの手足、またはさらに悪いことに、ダメージに深刻な減少を伴う重度の先天性欠損、不足している武器を持っていたことを発見した何千も薬剤によって損傷生まれた生きたすべての子を数えるようになった。唯一の完全な記録は、1970年代にドイツ、イギリス、日本、スウェーデン、オーストラリアで設立された国家補償方式、に参加するのに十分な長生き残った人々のである。災害を完全に通行料を暴くの難しさは、流産や死産の未知数（おそらく生児出生の10倍の数まで）、および嬰児の広範な練習から始まる。
赤ちゃんが生まれた後にサリドマイドの怪我は停止しませんでした。主に筋肉や関節（筋骨格痛）から、大部分が欠落しているか損傷し手足と共に生きるの挑戦の結果として - 50歳の時、サリドマイドトラストの記録は、すべての生存者の約半数が慢性疼痛に対処していることを示している。多くの人にとって、自分の体は健常人よりもはるかに速く悪化している。いくつかは、年齢の四〇から五〇歳で良いニュースではない、「あなたの体は70代の誰かの問題を得ている」旨の言葉を言われている。少なくとも、四半期には、彼らの影響を受けた四肢の発達神経学的な問題、うずき、しびれ、痛みに対処されています。これは、人が、たとえば、カップを保持することができ、彼らが知っている次の事は、それが原因で彼らの手のしびれのため、床に落ちたし、壊れていることを意味します。これらの生存者のために、災害はまだゆっくりと彼らの日々の生活の中で展開されている。
Grünenthalの科学者は問題の報告が入ってきたときだけでなく、薬剤を撤回することができないで怠慢だったか、失敗するのは時間の基準に従ってそれをテストするための、より多くの企業よりも、彼らは非常によく可能性を予想するために置かれたサリドマイドだろうと先天性欠損症を引き起こす。
Grünenthalは当初、薬物が広く、時間の基準に従ってテストされていなかったの主張を否定したが、スキャンダルは否定できないとなったら、それらを非難し、限界ダメージを偏向しようとした。
先天性欠損症の原因は - 1961年にサリドマイドは、最終的にteratoganであることが判明された後に撤回された。 12年後、英国の会社ラーズ·バイオケミカルズ·リミテッド（現ディアジオ） - 英国で薬物を分配するための責任があった - 被災者の家族による法廷闘争以下の補償和解に達した。
この和解は、不十分なレベルであることが判明した不完全な医学的証拠とサリドマイド生存者の将来の非現実的な期待に基づいている必要がありますベース。英国内のすべてのサリドマイドの生存者で、今50歳以上、それはもはや彼らの生活費の上昇、そして自分の健康の劇的な悪化に対処するのに十分ではありません。
この日に、Grünenthalはサリドマイドによって引き起こされる苦しみの責任を受け入れたことがありません。 9月1日2012年、Grünenthalグループは、赤ちゃんへ導いたそれを "後悔"薬の影響は、1950年代と1960年代に手足ずに生まれていることを示す、謝罪を含む声明を発表した。文はいくつかのサリドマイド生存者に歓迎されたものの、それはまだ責任の受け入れではありません。彼らはただ、快適な生活をしたい、それがGrünenthalが責任を負うと財政的に自分の過ちのために支払うべきであることを意味します。
Saridomaido wa 1953-nen ni Grünenthal ni yotte sakusei sa reta to tsuwari, zutsū, seki, fumin ya kaze o chiryō suru tame no `tokkōyaku' to shite, 1950-nendai kōhan kara 1960-nendai shotō ni shiyō sa reta. Saridomaido wa 1958-nen ni meishō Distaval no shita ni Igirisu de hanbai sa reta, to kōkoku wa sono yō na `hi dokusei' to `shira rete inai dokusei' nado no furēzu o shiyō shite, yakuzai no kanzen'na anzen-sei o kyōchō shita. Saridomaido o totte ita hahaoya ni subete - shikashi, 1961-nen ni ōsutoraria no ishi, U~Iriamu· makuburaido wa, kare no byōin de umareta akachan henkei no zōka ni kidzuita nochi, ransetto-shi ni tegami o kaita. 1958 To 1962 no ma de jū yōroppa zendo no josei no nan sen-ri mo no karera wa tanjō soreha shizandatta to iwa retata nochi ni, karera ga dō iu wake ka hakonde ita akachan ga, akka shi ryūzan shi, matawa koto ga wakatta. Motto jibun no akachan wa 1962 rekōdokīpā no ma ni ashi, matawa nado karera no naizō, nō, shinzō, jinzō, chō, seishokki, korera no teashi, matawa saraniwaruikoto ni, damēji ni shinkokuna genshō o tomonau jūdo no senten-sei kesson, fusoku shite iru buki o motte ita koto o hakken shita nan sen mo yakuzai ni yotte sonshō umareta ikita subete no ko o kazoeru yō ni natta. Yuiitsu no kanzen'na kiroku wa, 1970-nendai ni Doitsu, Igirisu, Nihon, suu~ēden, ōsutoraria de setsuritsu sa reta kokka hoshō hōshiki, ni sanka suru no ni jūbun'na naga ikinokotta hitobito nodearu. Saigai o kanzen ni tsūkō-ryō o abaku no muzukashi-sa wa, ryūzan ya shizan no michisū (osoraku nama-ji shussei no 10-bai no kazu made), oyobi midorigo no kōhan'na renshū kara hajimaru. Akachan ga umareta nochi ni Saridomaido no kega wa teishi shimasendeshita. Omoni kin'niku ya kansetsu (suji kokkaku-tsū) kara, daibubun ga ketsuraku shite iru ka sonshō shi teashi to tomoniikiru no chōsen no kekka to shite - 50-sai no toki, saridomaidotorasuto no kiroku wa, subete no seizon-sha no yaku hansū ga mansei tōtsū ni taisho shite iru koto o shimeshite iru. Ōku no hito ni totte, jibun no karada wa kenjō hito yori mo haruka ni hayaku akka shite iru. Ikutsu ka wa, nenrei no shi rei kara go rei-saide yoi nyūsude wanai, `anata no karada wa 70-dai no dareka no mondai o ete iru' mune no kotoba o iwa rete iru. Sukunakutomo, shihanki ni wa, karera no eikyō o uketa shishi no hattatsu shinkeigakutekina mondai, uzuki, shibire, itami ni taisho sa rete imasu. Kore wa, hito ga, tatoeba, kappu o hoji suru koto ga deki, karera ga shitte iru tsugi no koto wa, sore ga gen'in de karera no te no shibire no tame, yuka ni ochitashi, kowarete iru koto o imi shimasu. Korera no seizon-sha no tame ni, saigai wa mada yukkuri to karera no hibi no seikatsu no naka de tenkai sa rete iru. Grünenthal no kagaku-sha wa mondai no hōkoku ga haitte kita toki dakedenaku, yakuzai o tekkai suru koto ga dekinaide taimandatta ka, shippai suru no wa jikan no kijun ni shitagatte sore o tesuto suru tame no, yori ōku no kigyō yori mo, karera wa hijō ni yoku kanōsei o yosō suru tame ni oka reta Saridomaidodarou to senten-sei kesson-shō o hikiokosu. Grünenthal wa tōsho, yakubutsu ga hiroku, jikan no kijun ni shitagatte tesuto sa rete inakatta no shuchō o hitei shitaga, sukyandaru wa hiteidekinai to nattara, sorera o hinan shi, genkai damēji o henkō shiyou to shita. Senten-sei kesson-shō no gen'in wa - 1961-nen ni Saridomaido wa, saishūtekini teratogandearu koto ga hanmei sa reta nochi ni tekkai sa reta. 12-Nen-go, Igirisu no kaisha rāzu· baiokemikaruzu· rimiteddo (gen diajio) - Igirisu de yakubutsu o bunpai suru tame no sekinin ga atta - hisai-sha no kazoku ni yoru hōtei tōsō ika no hoshō wakai ni tasshita. Kono wakai wa, fujūbun'na reberudearu koto ga hanmei shita fukanzen'na igaku-teki shōko to Saridomaido seizon-sha no shōrai no higenjitsutekina kitai ni motodzuite iru hitsuyō ga arimasu bēsu. Igirisu-nai no subete no Saridomaido no seizon-sha de, ima 50-sai ijō, sore wa mohaya karera no seikatsu-hi no jōshō, soshite jibun no kenkō no gekitekina akka ni taisho suru no ni jūbunde wa arimasen. Kono Ni~Tsu ni, Grünenthal wa Saridomaido ni yotte hikiokosa reru kurushimi no sekinin o ukeireta koto ga arimasen. 9 Tsuki 1-nichi 2012-nen, Grünenthal gurūpu wa, akachan e michibiita sore o" kōkai"-yaku no eikyō wa, 1950-nendai to 1960-nendai ni teashizu ni umarete iru koto o shimesu, shazai o fukumu seimei o happyō shita. Bun wa ikutsu ka no Saridomaido seizon-sha ni kangei sa reta mono no, sore wa mada sekinin no ukeirede wa arimasen. Karera wa tada, kaitekina seikatsu o shitai, sore ga Grünenthal ga sekininwoou to zaisei-teki ni jibun no ayamachi no tame ni shiharaubekidearu koto o imi shimasu.
Welsh
Thalidomid ei greu gan Grünenthal ym 1953 ac fe'i defnyddiwyd yn y 1950au hwyr a'r 1960au cynnar fel "cyffur rhyfeddod" i drin salwch bore, cur pen, peswch, anhunedd ac annwyd. Thalidomid ei farchnata yn y DU o dan yr enw Distaval ym 1958, a hysbysebion yn pwysleisio diogelwch cyflawn y cyffur, gan ddefnyddio ymadroddion megis "heb fod yn wenwynig" a "dim gwenwyndra hysbys".
Fodd bynnag, yn 1961 meddyg Awstralia, William McBride, ysgrifennodd at y Lancet ar ôl sylwi cynnydd mewn babanod deformed cael eu geni yn ei ysbyty - i gyd i famau a oedd wedi cymryd Thalidomide.
Rhwng 1958 a 1962 degau o filoedd o ferched ledled Ewrop gwelwyd bod y baban eu bod yn cario miscarried anesboniadwy, neu, yn waeth, ar ôl iddynt roi genedigaeth Dywedwyd wrthym ei fod yn farw-anedig. Mae miloedd mwy darganfod bod gan eu babanod namau geni difrifol, breichiau goll, coesau, neu gyda gostyngiadau difrifol i aelodau hyn, neu hyd yn oed yn waeth, difrod i'w organau mewnol, yr ymennydd, y galon, yr arennau, coluddion, organau cenhedlu, ac ati Yn ystod 1962 geidwaid record dechreuodd i gyfrif pob un o'r plant sy'n byw a anwyd niweidio gan y cyffur. Yr unig cofnodion cyflawn yn y rhai a oroesodd yn ddigon hir i gymryd rhan yn y cynlluniau iawndal cenedlaethol, a sefydlwyd yn yr Almaen, Prydain, Japan, Sweden ac Awstralia yn y 1970au. Yr anhawster mewn datgelu y doll llawn y drychineb yn dechrau gyda nifer anhysbys o gamesgor a marw-enedigaethau (o bosibl hyd at ddeg gwaith y nifer o enedigaethau byw), ac mae'r arfer cyffredin o babanladdiad.
Nid oedd yr anafiadau Thalidomide oedd yn rhoi'r gorau unwaith y bydd y babanod eu geni. Ar hanner cant oed, cofnodion yr Ymddiriedolaeth Thalidomid yn dangos bod tua hanner yr holl goroeswyr yn ymdopi â phoen cronig - yn bennaf o gyhyrau a chymalau (poen cyhyrysgerbydol), yn bennaf o ganlyniad i heriau o fyw gyda aelodau goll neu wedi'u difrodi. I lawer, mae eu cyrff yn dirywio yn llawer gyflymach na phobl abl. Mae nifer wedi cael gwybod y geiriau i'r perwyl "eich corff yn cael y problemau y bydd rhywun yn eu saithdegau", a oedd yn 40-50 mlwydd oed nad yw newyddion da. Mae o leiaf chwarter yn ymdopi â datblygu problemau niwrolegol, pinnau bach, diffyg teimlad, a phoen yn eu coesau yr effeithir arnynt. Mae hyn yn golygu y gall person gael ei dal cwpan, er enghraifft, a'r peth nesaf eu bod yn gwybod ei fod wedi disgyn i'r llawr ac yn torri, oherwydd y diffyg teimlad yn eu llaw. Ar gyfer goroeswyr hyn, mae'r drychineb yn dal yn datblygu yn araf yn eu bywydau o ddydd i ddydd.
Gwyddonwyr Grünenthal oedd nid yn unig yn esgeulus wrth fethu i dynnu'r cyffur pan ddaeth adroddiadau am broblemau mewn, neu am fethu i brofi ei fod yn ôl y safonau ar y pryd, ond yn fwy na'r rhan fwyaf o gwmnïau eu bod mewn sefyllfa dda iawn i ragweld y posibilrwydd y byddai Thalidomide achosi namau geni.
Grünenthal i ddechrau gwadu honiadau nad oedd y cyffur wedi cael ei brofi'n helaeth yn ôl y safonau ar y pryd, ond unwaith y bydd y sgandal daeth yn ddiymwad, maent yn ceisio symud y bai a therfyn difrod.
Ym 1961 Thalidomide ei dynnu'n ôl yn y pen draw ar ôl ei gael i fod yn teratogan - un o achosion o namau geni. 12 mlynedd yn ddiweddarach, mae'r DU Distillers Biochemicals cwmni Limited (Diageo erbyn hyn) - a oedd yn gyfrifol am ddosbarthu'r cyffur yn y DU - cyrraedd setliad iawndal yn dilyn brwydr gyfreithiol gan deuluoedd y rhai yr effeithir arnynt.
Yn seiliedig ar dystiolaeth feddygol anghyflawn a disgwyliadau afrealistig o oroeswyr Thalidomide anghenion y dyfodol setliad hwn wedi troi allan i fod ar lefel annigonol. Gyda'r holl goroeswyr Thalidomid yn y DU bellach dros 50 oed, ei bod yn ddigonol i ddelio â'u cynnydd mewn costau byw, ac mae'r dirywiad dramatig ar eu hiechyd mwyach.
Hyd heddiw, erioed Grünenthal wedi derbyn cyfrifoldeb am y dioddefaint a achosir gan Thalidomide. Ar 1 Medi 2012, rhyddhawyd y Grŵp Grünenthal datganiad sy'n cynnwys ymddiheuriad, gan ddweud ei fod yn "difaru" y canlyniadau y cyffur, a arweiniodd at fabanod yn cael eu geni heb aelodau yn ystod y 1950au a'r 1960au. Er bod y datganiad yn ei groesawu gan rai goroeswyr Thalidomid, nid yw'n dal i fod yn derbyn cyfrifoldeb. Maent yn unig yn awyddus i fyw bywyd cyfforddus, ac mae hynny'n golygu y dylai Grünenthal fod yn atebol ac yn talu am eu camgymeriad yn ariannol.
Capt. (Dr.) Wesley Reynolds studies a patient’s computed tomography scan at the Mike O’Callaghan Federal Medical Center March 18, 2014, at Nellis Air Force Base, Nev. March is brain injury awareness month. According to the Brain Injury Association of America, about 75 percent of traumatic brain injuries are concussions or other forms of mild TBIs. Reynolds is a 99th Medical Operations Squadron neurologist. (U.S. Air Force photo by Senior Airman Jason Couillard/Released)
Bio: www.ninds.nih.gov/find_people/ninds/bio_walter_koroshetz.htm
Credit: National Institute of Neurological Disorders and Stroke
The Bethune International Peace Hospital uses stem cell technology to treat rare degenerative neurologic disorders such as ALS (Lou Gerhig's Disease), MS, and Parkinson's disease.
Laboratorio di Neuropsicofisiologia Sperimentale della Fondazione Santa Lucia. Diretto dal Dott. Giacomo Koch.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.
Nov 19 2008
NOOOOOOOOOOOOOO!!!!!
Actually, I'm not really upset about anything. I just thought it would look cool. And I'm procrastinating. My neurology written exam is on Friday.
Texture and Broken Glass.
Medical Moment
The evidence for the value of primary care is clear: better quality of life, more
productive longevity, and lower costs as a result of reduced hospitalization
improved prevention and better coordination of chronic disease care. The
nation must take immediate steps to address the issues that threaten primary
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purchasers, health plans, and the medical profession itself to take immediate
action to create a comprehensive national health care workforce policy with a
focus on primary care; adopt a patient-centered physician guided model of
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payment policies to support the value of care provided by primary care physicians. The consequences of failing to act will be higher costs, greater inefficiency,
lower quality, more uninsured persons, and growing patient and physician
dissatisfaction. Averting the collapse of primary care is the best cure for an ailing
health care system.
Examination Anaesthesia is a detailed guide to aid the approach of anaesthetic trainees sitting the final fellowship examination of the Australian and New Zealand College of Anaesthetists (ANZCA).
The format of the ANZCA final examination has evolved in recent years, and this update to the exam guide aims to keep pace with those developments. All of the requirements of the FANZCA training scheme and components of the final examination are detailed, including a breakdown of the marking scheme and recent results.
Relevant resources (including new developments on the College website, textbooks, journals and exam courses) and practical strategies for restructuring life around exam preparation are provided. Separate chapters based on the major components of the written and clinical examinations, and a broad list of reference and review articles are included.
New to this Edition
•details the new examination format (altered component weighting, spatial and temporal separation of medical and anaesthesia vivas)
•upgraded information on exam preparation courses
•expanded chapter on approaching the written components of the exam
•expansion of medical viva chapter to 21 case examples with increased representation of cardiovascular, endocrine and neurological conditions
•dissection of recent examinations, listing short answer and viva questions under relevant topic headings to aid study
•rewritten data interpretation section with a focus relating to anaesthetic practice; many new radiographs, electrocardiographs and other tabulated data (including echocardiography, arterial blood gas analysis, coagulation studies and sleep studies)
•complete update of the reference and review article section
Author Information:
Christopher Thomas BMedSc MBBS FANZCA
Consultant Visiting Medical Officer (Anaesthesia), The Ipswich Hospital; Specialist Anaesthetist, St Andrew’s Ipswich Hospital & Ipswich Day Hospital; Clinical Senior Lecturer, School of Medicine, University of Queensland, Brisbane, Queensland
Christopher Butler MBBS FANZCA MPH&TM CertDHM PGDipEcho
Senior Staff Specialist, Department of Anaesthesia, The Townsville Hospital; Clinical Senior Lecturer, School of Medicine, James Cook University, Townsville, Queensland
Click here to find out more or to purchase this book.
www.medical-explorer.com/epilepsy.php
Epilepsy (sometimes referred to as a seizure disorder) is a common chronic neurological condition that is characterized by recurrent unprovoked epileptic seizures. It affects approximately 50 million people worldwide.It is usually controlled, but not cured, with medication – although surgery may be considered in difficult cases.
Laboratorio di Epigenetica e Trasduzione del Segnale della Fondazione Santa Lucia. Diretto dal Dott.ssa Daniela Palacios.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.
Time Line
nuk-tnl-editorial-prod-staticassets.s3.amazonaws.com/2014...
History
Thalidomide was created by Grünenthal in 1953 and was used in the late 1950s and early 1960s as a "wonder drug" to treat morning sickness, headaches, coughs, insomnia and colds. Thalidomide was marketed in the UK under the name Distaval in 1958, and advertisements emphasized the drug's complete safety, using phrases such as “non-toxic” and “no known toxicity”.
However, in 1961 an Australian doctor, William McBride, wrote to the Lancet after noticing an increase in deformed babies being born at his hospital – all to mothers who had taken Thalidomide.
Between 1958 and 1962 tens of thousands of women throughout Europe found that the baby they were carrying unaccountably miscarried, or, worse, after they gave birth were told it was stillborn. Thousands more discovered that their babies had severe birth defects, missing arms, legs, or with severe reductions to these limbs, or even worse, damage to their internal organs, brain, heart, kidneys, intestines, genitals, etc. During 1962 record keepers began to count all of the children living who were born damaged by the drug. The only complete records are of those who survived long enough to participate in the national compensation schemes, which were established in Germany, Britain, Japan, Sweden and Australia in the 1970s. The difficulty in uncovering the full toll of the disaster begins with the unknown numbers of miscarriages and stillbirths (possibly up to ten times the number of live births), and the widespread practice of infanticide.
The Thalidomide injuries did not stop once the babies were born. At the age of fifty, the Thalidomide Trust’s records show that around half of all survivors are coping with chronic pain – mainly from muscles and joints (musculo-skeletal pain), largely as a result of the challenges of living with missing or damaged limbs. For many, their bodies are deteriorating far faster than able-bodied people. Several have been told words to the effect “your body is getting the problems of someone in their seventies”, which at forty to fifty years of age is not good news. At least a quarter are coping with developing neurological problems, tingling, numbness, and pain in their affected limbs. This means that a person may be holding a cup, for instance, and the next thing they know is it has fallen to the floor and broken, because of the numbness in their hand. For these survivors, the disaster is still slowly unfolding in their day-to-day lives.
Grünenthal scientists were not only negligent in failing to withdraw the drug when reports of problems came in, or for failing to test it according to the standards of the time, but more than most companies they were very well placed to anticipate the possibility that Thalidomide would cause birth defects.
Grünenthal initially denied claims that the drug hadn’t been extensively tested according to the standards of the time, but once the scandal became undeniable, they sought to deflect blame and limit damage.
In 1961 Thalidomide was eventually withdrawn after being found to be a teratogan - a cause of birth defects. 12 years later, the UK company Distillers Biochemicals Limited (now Diageo) – which was responsible for distributing the drug in the UK – reached a compensation settlement following a legal battle by the families of those affected.
Based on incomplete medical evidence and unrealistic expectations of Thalidomide survivors future needs this settlement has turned out to be at an inadequate level. With all Thalidomide survivors in the UK now over the age of 50, it is no longer sufficient to deal with their rising cost of living, and the dramatic deterioration of their health.
To this day, Grünenthal have never accepted responsibility for the suffering caused by Thalidomide. On September 1st 2012, The Grünenthal Group released a statement containing an apology, stating that it "regrets" the consequences of the drug, which led to babies being born without limbs during the 1950s and 1960s. Although the statement was welcomed by some Thalidomide survivors, it is still not an acceptance of responsibility. They just want to live a comfortable life, and that means Grünenthal should be held accountable and pay for their mistake financially.
Spanish
Historia
La talidomida fue creado por Grünenthal en 1953 y fue utilizado a finales de 1950 y principios de 1960 como una "droga milagrosa" para el tratamiento de las náuseas, dolores de cabeza, tos, insomnio y resfriados. La talidomida fue comercializada en el Reino Unido bajo el nombre Distaval en 1958, y destacó los anuncios de seguridad completa del medicamento, utilizando frases como "no tóxico" y "no hay toxicidad conocida".
Sin embargo, en 1961 un médico australiano, William McBride, escribió a la revista The Lancet después de notar un aumento en los bebés que nacen deformes en su hospital - todo a las madres que habían tomado Talidomida.
Entre 1958 y 1962, decenas de miles de mujeres de toda Europa descubrieron que el bebé que llevaban inexplicablemente abortado, o, peor aún, después de dar a luz se les dijo que estaba muerto. Miles de personas descubrieron que sus bebés nacieron con defectos congénitos graves, los brazos, las piernas, que faltan o con reducciones severas a estos miembros, o peor aún, el daño a sus órganos internos, cerebro, corazón, riñones, intestinos, genitales, etc Durante 1962 guardianes de los registros empezó a contar toda la vida los niños que nacieron dañado por la droga. Los únicos registros completos son de los que sobrevivieron lo suficiente como para participar en los sistemas nacionales de indemnización, que se establecieron en Alemania, Gran Bretaña, Japón, Suecia y Australia en la década de 1970. La dificultad para descubrir el número de víctimas del desastre comienza con los números desconocidos de abortos involuntarios y mortinatos (posiblemente hasta diez veces el número de nacidos vivos), y la práctica generalizada del infanticidio.
Las lesiones de la talidomida no se detuvo una vez que los bebés nacieron. A la edad de cincuenta años, los registros de la confianza talidomida muestran que cerca de la mitad de todos los sobrevivientes están lidiando con el dolor crónico - principalmente de músculos y articulaciones (dolor musculoesquelético), en gran parte como resultado de los desafíos de vivir con la falta o ramas dañadas. Para muchos, sus cuerpos se deterioran mucho más rápido que las personas sanas. Algunos han dicho palabras en el sentido de "su cuerpo está recibiendo los problemas de alguien en los setenta", que a los cuarenta o cincuenta años de edad no es una buena noticia. Al menos una cuarta están lidiando con el desarrollo de problemas neurológicos, hormigueo, entumecimiento y dolor en las extremidades afectadas. Esto significa que una persona puede ser la celebración de una taza, por ejemplo, y lo siguiente que sé es que ha caído al suelo y se rompe, debido a la sensación de adormecimiento en la mano. Para estos sobrevivientes, el desastre está siendo poco a poco se desarrolla en su día a día.
Grünenthal científicos no sólo fueron negligentes al no haber retirado la droga cuando los informes de problemas de vino, o por no probarlo de acuerdo a los estándares de la época, pero más que la mayoría de las empresas que estaban muy bien situados para prever la posibilidad de que la talidomida haría causar defectos de nacimiento.
Grünenthal inicialmente negó las acusaciones de que el medicamento no ha sido ampliamente probado de acuerdo con los estándares de la época, pero una vez que el escándalo se hizo innegable, trataron de desviar la culpa y limitar el daño.
En 1961, la talidomida fue finalmente retirada después de haber sido encontrado para ser un teratogan - una de las causas de los defectos congénitos. 12 años después, el Reino Unido, Distillers Company Limited (ahora Bioquímicos Diageo) - encargada de la distribución de la droga en el Reino Unido - llegó a un acuerdo de compensación después de una batalla legal por las familias de los afectados.
Sobre la base de evidencia incompleta médica y expectativas poco realistas de la talidomida futuro sobrevivientes necesita esta solución ha resultado ser en un nivel adecuado. Con todos los sobrevivientes de la talidomida en el Reino Unido ahora más de 50 años de edad, ya no es suficiente para hacer frente a su creciente costo de vida, y el dramático deterioro de su salud.
A día de hoy, Grünenthal nunca ha aceptado la responsabilidad por el sufrimiento causado por la talidomida. El 1 de septiembre de 2012, el Grupo Grünenthal emitió una declaración que contenga una disculpa, diciendo que "lamenta" las consecuencias de la droga, lo que llevó a los bebés que nacen sin extremidades durante los años 1950 y 1960. Aunque la declaración fue bien recibida por algunos sobrevivientes de la talidomida, no es todavía una aceptación de responsabilidad. Ellos sólo quieren vivir una vida cómoda, y eso quiere decir Grünenthal deben rendir cuentas y pagar por su error financieramente.
Italian
Storia
La talidomide è stato creato da Grünenthal nel 1953 ed è stato utilizzato alla fine del 1950 e 1960 come un "farmaco miracoloso" per curare la malattia di mattina, mal di testa, tosse, insonnia e raffreddori. La talidomide è stato commercializzato nel Regno Unito con il nome di Distaval nel 1958, e la pubblicità ha sottolineato sicurezza del farmaco, con frasi come "non tossico" e "nessuna tossicità conosciuto".
Tuttavia, nel 1961 un medico australiano, William McBride, ha scritto al Lancet dopo aver notato un aumento delle nascite di bimbi malformati essendo nati a suo ospedale - tutti da madri che avevano assunto talidomide.
Tra il 1958 e il 1962 decine di migliaia di donne in tutta Europa ha scoperto che il bambino che portavano inspiegabilmente abortito, o, peggio, dopo che ha dato alla luce hanno detto che era morto. Altre migliaia hanno scoperto che i loro bambini hanno gravi difetti di nascita, braccia, gambe, mancanti o con gravi riduzioni a queste arti, o peggio ancora, danni ai loro organi interni, cervello, cuore, reni, intestino, genitali, ecc Nel 1962 custodi record cominciò a contare tutta la vita i bambini che sono nati danneggiati dal farmaco. Le uniche registrazioni complete sono di coloro che sono sopravvissuti abbastanza a lungo per partecipare ai sistemi di indennizzo nazionali, che sono stati stabiliti in Germania, Gran Bretagna, Giappone, Svezia e Australia nel 1970. La difficoltà nello scoprire il bilancio del disastro inizia con i numeri sconosciuti di aborti spontanei e nati morti (forse fino a dieci volte il numero di nati vivi), e la pratica diffusa di infanticidio.
Le lesioni Talidomide non si è fermata una volta che i bambini sono nati. All'età di 50, del Trust talidomide i tabulati mostrano che circa la metà di tutti i sopravvissuti stanno affrontando con dolore cronico - principalmente da muscoli e le articolazioni (il dolore muscoloscheletrico), soprattutto a causa delle sfide della vita con mancanti o arti danneggiati. Per molti, i loro corpi si stanno deteriorando molto più veloce di persone abili. Molti hanno detto parole per l'effetto "il tuo corpo è sempre il problema di qualcuno nei loro anni settanta", che a 40-50 anni di età non è una buona notizia. Almeno un quarto stanno affrontando con lo sviluppo di problemi neurologici, formicolio, intorpidimento e dolore a carico degli arti colpiti. Ciò significa che una persona può essere in possesso di un tazza, per esempio, e la prossima cosa che so è che è caduto a terra e rotto, a causa del torpore in mano. Per questi sopravvissuti, il disastro è ancora lentamente svolgendo nel loro giorno per giorno la vita.
Grünenthal scienziati non erano solo negligenza nel non ritirare il farmaco quando i report di problemi è venuto in, o per non aver testarlo secondo gli standard del tempo, ma più che la maggior parte delle aziende erano molto ben disposti ad anticipare la possibilità che Thalidomide avrebbe causare difetti di nascita.
Grünenthal inizialmente smentito che il farmaco non era stato ampiamente testati secondo gli standard del tempo, ma una volta che lo scandalo è diventata innegabile, hanno cercato di deviare la colpa e di limitare i danni.
Nel 1961 talidomide è stata infine ritirata dopo essere stato trovato per essere un teratogan - una causa di difetti di nascita. 12 anni dopo, i Distillers Company Limited, Regno Unito Biochemicals (ora Diageo) - incaricata di distribuire il farmaco nel Regno Unito - ha raggiunto un accordo di compensazione a seguito di una battaglia legale da parte delle famiglie delle persone colpite.
Sulla base di prove mediche incomplete e le aspettative non realistiche del futuro Thalidomide sopravvissuti ha bisogno di questa soluzione si è rivelata essere ad un livello insufficiente. Con tutti i sopravvissuti Talidomide nel Regno Unito ora di età superiore ai 50 anni, non è più sufficiente per affrontare la loro crescente costo della vita, e il drammatico deterioramento della loro salute.
Fino ad oggi, la Grünenthal non hanno mai accettato la responsabilità per la sofferenza causata dal talidomide. Il 1 ° settembre 2012, il Gruppo Grünenthal ha rilasciato una dichiarazione che contiene delle scuse, affermando che esso "deplora" le conseguenze della droga, che ha portato a bambini nati senza arti nel corso del 1950 e 1960. Anche se la dichiarazione è stata accolta da alcuni sopravvissuti talidomide, non è ancora una assunzione di responsabilità. Vogliono solo vivere una vita comoda, e questo significa che Grünenthal dovrebbero essere ritenuti responsabili e pagare per il loro errore finanziario.
More History
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History
Thalidomide was created by Grünenthal in 1953 and was used in the late 1950s and early 1960s as a "wonder drug" to treat morning sickness, headaches, coughs, insomnia and colds. Thalidomide was marketed in the UK under the name Distaval in 1958, and advertisements emphasized the drug's complete safety, using phrases such as “non-toxic” and “no known toxicity”.
However, in 1961 an Australian doctor, William McBride, wrote to the Lancet after noticing an increase in deformed babies being born at his hospital – all to mothers who had taken Thalidomide.
Between 1958 and 1962 tens of thousands of women throughout Europe found that the baby they were carrying unaccountably miscarried, or, worse, after they gave birth were told it was stillborn. Thousands more discovered that their babies had severe birth defects, missing arms, legs, or with severe reductions to these limbs, or even worse, damage to their internal organs, brain, heart, kidneys, intestines, genitals, etc. During 1962 record keepers began to count all of the children living who were born damaged by the drug. The only complete records are of those who survived long enough to participate in the national compensation schemes, which were established in Germany, Britain, Japan, Sweden and Australia in the 1970s. The difficulty in uncovering the full toll of the disaster begins with the unknown numbers of miscarriages and stillbirths (possibly up to ten times the number of live births), and the widespread practice of infanticide.
The Thalidomide injuries did not stop once the babies were born. At the age of fifty, the Thalidomide Trust’s records show that around half of all survivors are coping with chronic pain – mainly from muscles and joints (musculo-skeletal pain), largely as a result of the challenges of living with missing or damaged limbs. For many, their bodies are deteriorating far faster than able-bodied people. Several have been told words to the effect “your body is getting the problems of someone in their seventies”, which at forty to fifty years of age is not good news. At least a quarter are coping with developing neurological problems, tingling, numbness, and pain in their affected limbs. This means that a person may be holding a cup, for instance, and the next thing they know is it has fallen to the floor and broken, because of the numbness in their hand. For these survivors, the disaster is still slowly unfolding in their day-to-day lives.
Grünenthal scientists were not only negligent in failing to withdraw the drug when reports of problems came in, or for failing to test it according to the standards of the time, but more than most companies they were very well placed to anticipate the possibility that Thalidomide would cause birth defects.
Grünenthal initially denied claims that the drug hadn’t been extensively tested according to the standards of the time, but once the scandal became undeniable, they sought to deflect blame and limit damage.
In 1961 Thalidomide was eventually withdrawn after being found to be a teratogan - a cause of birth defects. 12 years later, the UK company Distillers Biochemicals Limited (now Diageo) – which was responsible for distributing the drug in the UK – reached a compensation settlement following a legal battle by the families of those affected.
Based on incomplete medical evidence and unrealistic expectations of Thalidomide survivors future needs this settlement has turned out to be at an inadequate level. With all Thalidomide survivors in the UK now over the age of 50, it is no longer sufficient to deal with their rising cost of living, and the dramatic deterioration of their health.
To this day, Grünenthal have never accepted responsibility for the suffering caused by Thalidomide. On September 1st 2012, The Grünenthal Group released a statement containing an apology, stating that it "regrets" the consequences of the drug, which led to babies being born without limbs during the 1950s and 1960s. Although the statement was welcomed by some Thalidomide survivors, it is still not an acceptance of responsibility. They just want to live a comfortable life, and that means Grünenthal should be held accountable and pay for their mistake financially.
Spanish
Historia
La talidomida fue creado por Grünenthal en 1953 y fue utilizado a finales de 1950 y principios de 1960 como una "droga milagrosa" para el tratamiento de las náuseas, dolores de cabeza, tos, insomnio y resfriados. La talidomida fue comercializada en el Reino Unido bajo el nombre Distaval en 1958, y destacó los anuncios de seguridad completa del medicamento, utilizando frases como "no tóxico" y "no hay toxicidad conocida".
Sin embargo, en 1961 un médico australiano, William McBride, escribió a la revista The Lancet después de notar un aumento en los bebés que nacen deformes en su hospital - todo a las madres que habían tomado Talidomida.
Entre 1958 y 1962, decenas de miles de mujeres de toda Europa descubrieron que el bebé que llevaban inexplicablemente abortado, o, peor aún, después de dar a luz se les dijo que estaba muerto. Miles de personas descubrieron que sus bebés nacieron con defectos congénitos graves, los brazos, las piernas, que faltan o con reducciones severas a estos miembros, o peor aún, el daño a sus órganos internos, cerebro, corazón, riñones, intestinos, genitales, etc Durante 1962 guardianes de los registros empezó a contar toda la vida los niños que nacieron dañado por la droga. Los únicos registros completos son de los que sobrevivieron lo suficiente como para participar en los sistemas nacionales de indemnización, que se establecieron en Alemania, Gran Bretaña, Japón, Suecia y Australia en la década de 1970. La dificultad para descubrir el número de víctimas del desastre comienza con los números desconocidos de abortos involuntarios y mortinatos (posiblemente hasta diez veces el número de nacidos vivos), y la práctica generalizada del infanticidio.
Las lesiones de la talidomida no se detuvo una vez que los bebés nacieron. A la edad de cincuenta años, los registros de la confianza talidomida muestran que cerca de la mitad de todos los sobrevivientes están lidiando con el dolor crónico - principalmente de músculos y articulaciones (dolor musculoesquelético), en gran parte como resultado de los desafíos de vivir con la falta o ramas dañadas. Para muchos, sus cuerpos se deterioran mucho más rápido que las personas sanas. Algunos han dicho palabras en el sentido de "su cuerpo está recibiendo los problemas de alguien en los setenta", que a los cuarenta o cincuenta años de edad no es una buena noticia. Al menos una cuarta están lidiando con el desarrollo de problemas neurológicos, hormigueo, entumecimiento y dolor en las extremidades afectadas. Esto significa que una persona puede ser la celebración de una taza, por ejemplo, y lo siguiente que sé es que ha caído al suelo y se rompe, debido a la sensación de adormecimiento en la mano. Para estos sobrevivientes, el desastre está siendo poco a poco se desarrolla en su día a día.
Grünenthal científicos no sólo fueron negligentes al no haber retirado la droga cuando los informes de problemas de vino, o por no probarlo de acuerdo a los estándares de la época, pero más que la mayoría de las empresas que estaban muy bien situados para prever la posibilidad de que la talidomida haría causar defectos de nacimiento.
Grünenthal inicialmente negó las acusaciones de que el medicamento no ha sido ampliamente probado de acuerdo con los estándares de la época, pero una vez que el escándalo se hizo innegable, trataron de desviar la culpa y limitar el daño.
En 1961, la talidomida fue finalmente retirada después de haber sido encontrado para ser un teratogan - una de las causas de los defectos congénitos. 12 años después, el Reino Unido, Distillers Company Limited (ahora Bioquímicos Diageo) - encargada de la distribución de la droga en el Reino Unido - llegó a un acuerdo de compensación después de una batalla legal por las familias de los afectados.
Sobre la base de evidencia incompleta médica y expectativas poco realistas de la talidomida futuro sobrevivientes necesita esta solución ha resultado ser en un nivel adecuado. Con todos los sobrevivientes de la talidomida en el Reino Unido ahora más de 50 años de edad, ya no es suficiente para hacer frente a su creciente costo de vida, y el dramático deterioro de su salud.
A día de hoy, Grünenthal nunca ha aceptado la responsabilidad por el sufrimiento causado por la talidomida. El 1 de septiembre de 2012, el Grupo Grünenthal emitió una declaración que contenga una disculpa, diciendo que "lamenta" las consecuencias de la droga, lo que llevó a los bebés que nacen sin extremidades durante los años 1950 y 1960. Aunque la declaración fue bien recibida por algunos sobrevivientes de la talidomida, no es todavía una aceptación de responsabilidad. Ellos sólo quieren vivir una vida cómoda, y eso quiere decir Grünenthal deben rendir cuentas y pagar por su error financieramente.
Italian
Storia
La talidomide è stato creato da Grünenthal nel 1953 ed è stato utilizzato alla fine del 1950 e 1960 come un "farmaco miracoloso" per curare la malattia di mattina, mal di testa, tosse, insonnia e raffreddori. La talidomide è stato commercializzato nel Regno Unito con il nome di Distaval nel 1958, e la pubblicità ha sottolineato sicurezza del farmaco, con frasi come "non tossico" e "nessuna tossicità conosciuto".
Tuttavia, nel 1961 un medico australiano, William McBride, ha scritto al Lancet dopo aver notato un aumento delle nascite di bimbi malformati essendo nati a suo ospedale - tutti da madri che avevano assunto talidomide.
Tra il 1958 e il 1962 decine di migliaia di donne in tutta Europa ha scoperto che il bambino che portavano inspiegabilmente abortito, o, peggio, dopo che ha dato alla luce hanno detto che era morto. Altre migliaia hanno scoperto che i loro bambini hanno gravi difetti di nascita, braccia, gambe, mancanti o con gravi riduzioni a queste arti, o peggio ancora, danni ai loro organi interni, cervello, cuore, reni, intestino, genitali, ecc Nel 1962 custodi record cominciò a contare tutta la vita i bambini che sono nati danneggiati dal farmaco. Le uniche registrazioni complete sono di coloro che sono sopravvissuti abbastanza a lungo per partecipare ai sistemi di indennizzo nazionali, che sono stati stabiliti in Germania, Gran Bretagna, Giappone, Svezia e Australia nel 1970. La difficoltà nello scoprire il bilancio del disastro inizia con i numeri sconosciuti di aborti spontanei e nati morti (forse fino a dieci volte il numero di nati vivi), e la pratica diffusa di infanticidio.
Le lesioni Talidomide non si è fermata una volta che i bambini sono nati. All'età di 50, del Trust talidomide i tabulati mostrano che circa la metà di tutti i sopravvissuti stanno affrontando con dolore cronico - principalmente da muscoli e le articolazioni (il dolore muscoloscheletrico), soprattutto a causa delle sfide della vita con mancanti o arti danneggiati. Per molti, i loro corpi si stanno deteriorando molto più veloce di persone abili. Molti hanno detto parole per l'effetto "il tuo corpo è sempre il problema di qualcuno nei loro anni settanta", che a 40-50 anni di età non è una buona notizia. Almeno un quarto stanno affrontando con lo sviluppo di problemi neurologici, formicolio, intorpidimento e dolore a carico degli arti colpiti. Ciò significa che una persona può essere in possesso di un tazza, per esempio, e la prossima cosa che so è che è caduto a terra e rotto, a causa del torpore in mano. Per questi sopravvissuti, il disastro è ancora lentamente svolgendo nel loro giorno per giorno la vita.
Grünenthal scienziati non erano solo negligenza nel non ritirare il farmaco quando i report di problemi è venuto in, o per non aver testarlo secondo gli standard del tempo, ma più che la maggior parte delle aziende erano molto ben disposti ad anticipare la possibilità che Thalidomide avrebbe causare difetti di nascita.
Grünenthal inizialmente smentito che il farmaco non era stato ampiamente testati secondo gli standard del tempo, ma una volta che lo scandalo è diventata innegabile, hanno cercato di deviare la colpa e di limitare i danni.
Nel 1961 talidomide è stata infine ritirata dopo essere stato trovato per essere un teratogan - una causa di difetti di nascita. 12 anni dopo, i Distillers Company Limited, Regno Unito Biochemicals (ora Diageo) - incaricata di distribuire il farmaco nel Regno Unito - ha raggiunto un accordo di compensazione a seguito di una battaglia legale da parte delle famiglie delle persone colpite.
Sulla base di prove mediche incomplete e le aspettative non realistiche del futuro Thalidomide sopravvissuti ha bisogno di questa soluzione si è rivelata essere ad un livello insufficiente. Con tutti i sopravvissuti Talidomide nel Regno Unito ora di età superiore ai 50 anni, non è più sufficiente per affrontare la loro crescente costo della vita, e il drammatico deterioramento della loro salute.
Fino ad oggi, la Grünenthal non hanno mai accettato la responsabilità per la sofferenza causata dal talidomide. Il 1 ° settembre 2012, il Gruppo Grünenthal ha rilasciato una dichiarazione che contiene delle scuse, affermando che esso "deplora" le conseguenze della droga, che ha portato a bambini nati senza arti nel corso del 1950 e 1960. Anche se la dichiarazione è stata accolta da alcuni sopravvissuti talidomide, non è ancora una assunzione di responsabilità. Vogliono solo vivere una vita comoda, e questo significa che Grünenthal dovrebbero essere ritenuti responsabili e pagare per il loro errore finanziario.
Laboratorio per lo Studio delle Atassie della Fondazione Santa Lucia. Diretto dal Prof.ssa Maria Leggio.
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Laboratorio di Neuroimmagini Funzionali della Fondazione Santa Lucia. Diretto dal Dott. Marco Bozzali.
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Laboratorio di Biofilm Microbici della Fondazione Santa Lucia. Diretto dal Prof. Gianfranco Donelli.
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I use my art, in any media, to often work through life's issues especially physical pain. Most of the time I am a half-full kind of gal - today has been a black pit day. So I have worked through some issues and released the pain through imagery. I will sleep better now and tomorrow will be brighter! Thank God!!
Laboratorio di Neurologia Sperimentale della Fondazione Santa Lucia. Diretto dal Prof. Nicola Mercuri.
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Laboratorio di Neuroanatomia della Fondazione Santa Lucia. Diretto dalla Dott.ssa Francesca Fusco.
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Go to Page 322 in the Internet Archive
Title: Neurological bulletin. Clinical studies of nervous and mental diseases in the Neurological Department of Columbia University, v.3
Creator: Tilney, Frederick, 1875-1938
Creator: Columbia University. Dept. of Neurology
Publisher: New York, Paul B. Hoeber
Sponsor: Open Knowledge Commons
Contributor: Columbia University Libraries
Date: 1918
Vol: v.3
Language: eng
Suspended in 1920. Union list of serials
If you have questions concerning reproductions, please contact the Contributing Library.
Note: The colors, contrast and appearance of these illustrations are unlikely to be true to life. They are derived from scanned images that have been enhanced for machine interpretation and have been altered from their originals.
Read/Download from the Internet Archive
Laboratorio di Neuropsichiatria della Fondazione Santa Lucia. Diretto dal Dott. Gianfranco Spalletta.
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Part of Pripyats Hospital 126
Hospital No. 126, received the first victims of the Chernobyl accident, the basement still harbours some of their radioactive clothing. Shortly after the accident, firefighters arrived to try to extinguish the fires. First on the scene was a Chernobyl Power Station firefighter brigade under the command of Lieutenant Volodymyr Pravik, who died on 9 May 1986 of acute radiation sickness. They were not told how dangerously radioactive the smoke and the debris were.
"We didn't know much about radiation. Even those who worked there had no idea. There was no water left in the trucks. Misha filled a cistern and we aimed the water at the top. Then those boys who died went up to the roof – Vashchik, Kolya and others, and Volodya Pravik.... They went up the ladder ... and I never saw them again".
From eyewitness accounts of the firefighters involved before they died, one described his experience of the radiation as "tasting like metal", and feeling a sensation similar to that of pins and needles all over his face.
Rabies vaccination in dogs and cats is of paramount importance. In usa has been infected with rabies and in recent years dozens of cases of rabies-infested animals have been discovered that have not been immunized by a emergency vet as required by law, infecting all mammals including humans and caused by RNA virus. Transmission of the disease is mainly caused by biting, but the clinical signs are not specific but can cause neurological spasms and signs, rabies is incurable and in the case of clinical signs, the disease can not be treated.
Emergency vet think that The cause of rabies is viral and belongs to a family of RNA viruses and is one of the first diseases to be developed against the vaccine in 1885. The disease affects all mammals and it is now known that every few minutes a person dies in the world of rabies, especially in developing countries. The spread of the virus is global and can be transmitted by any individual belonging to the mammals (eg, dogs, cats, foxes, cows, etc.).
How do you get the disease? How does the disease progress?
1.The virus is secreted in the infected animal's saliva. The transmission is carried out by an animal bite whose saliva contains the virus or by contact with the saliva with exposed wounds. The virus migrates in the nervous system toward the spinal cord, where it proliferate quickly and rises toward the brain. When it reaches the brain, clinical signs begin to appear and the virus is secreted in the animal's saliva, sometimes the secretion of saliva occurs before the onset of clinical signs (sometimes even two weeks before).
2. The time from the bite to the onset of the signs can last from one day to the next, depending on the distance of the bitten area and the amount of virus injected (bite more than licking).
What are the clinical signs of rabies infection?
The disease can affect any mammal of any age. The clinical signs are not very specific and can be
Primary signs - restlessness, lack of eating, personality changes and vomiting and vomiting
In more advanced stages - depression, extreme restlessness, demancy, aggression, change of voice, fearless attack, difficulties in swallowing and eating, eating feces and non-food items.
In humans, the main clinical signs are fear of water (hydrophobia). Patients with the disease can not drink even a glass of water and are affected by paralyzing fear as a result of contact with water.
What is the reccommand treatment of the rabid animal by emergency vet?
Emergency vet do not treat an animal suspected of rabies and we send it to quarantine for about 10 days to see if the animal develops clinical signs that are suspicious of the disease.
A person bitten by a suspected rabid animal must go to the Ministry of Health and receive a passive vaccination against rabies as soon as possible. As soon as clinical signs appear, the disease is incurable.
Have not you vaccinated your pet yet?
For more pet tips and advice, please visit our channel:
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Laboratorio di Neuropsicologia Comportamentale della Fondazione Santa Lucia. Diretto dal Dott. Ugo Nocentini.
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Laboratorio di Neuroembriologia Molecolare della Fondazione Santa Lucia. Diretto dal Dott. Francesco Cecconi.
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Laboratorio di Neurobiofisica della Fondazione Santa Lucia. Diretto dalla Dott.ssa Cristina Zona.
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An Ode To Your Brain
I came across this video on You Tube and have to share it with you. It's called "Ode to the Brain" and I think it is wonderful.
A simple 3 minute and 42 second introduction to Neurology set to music and beautiful images.
your brain stores masses of information. The human brain is a mass of jelly you can hold in your hand and yet it can contemplate the vastness of interstellar space.
The brain encodes what we know in cells called Neurons and there is something like 100 Trillion neural connections
Your brain contains the equivalent of 20 million volumes of information and has been described as a very big place inside a very small space.
Information flows in as energy and explodes into a sensory experience.
No longer at the mercy of the reptile brain we can change ourselves. Think of the possibilities
mp3: symphonyofscience.com "Ode to the Brain" is the ninth episode in the Symphony of Science music video series. Through the powerful words of scientists Carl Sagan, Robert Winston, Vilayanur Ramachandran, Jill Bolte Taylor, Bill Nye, and Oliver Sacks, it covers different aspects the brain including its evolution, neuron networks, folding, and more. The material sampled for this video comes from Carl Sagan's Cosmos, Jill Bolte Taylor's TED Talk, Vilayanur Ramachandran's TED Talk, Bill Nye's Brain episode, BBC's "The Human Body", Oliver Sachs' TED Talk, Discovery Channel's "Human Body: Pushing the Limits", and more.