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Laboratorio di Trasduzione del Segnale della Fondazione Santa Lucia. Diretto dal Dott.ssa Daniela Barilà.
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Laboratorio di Trasduzione del Segnale della Fondazione Santa Lucia. Diretto dal Dott.ssa Daniela Barilà.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.
Laboratorio di Neurologia Sperimentale della Fondazione Santa Lucia. Diretto dal Prof. Nicola Mercuri.
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Prof. Nicola Mercuri, Responsabile del Laboratorio di Neurologia Sperimentale della Fondazione Santa Lucia.
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Laboratorio di Epigenetica e Trasduzione del Segnale della Fondazione Santa Lucia. Diretto dal Dott.ssa Daniela Palacios.
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CarolinaEast Medical Center: www.carolinaeasthealth.com/
Precision Race: www.precisionrace.com/
Carolina Brewing Company: www.carolinabrew.com/
Raleigh Neurology: www.raleighneurology.com/
Bike MS: secure.nationalmssociety.org/site/SPageNavigator/BIKE_HOM...
National Multiple Sclerosis Society:http://www.nationalmssociety.org/
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Help BikeMS New Bern Ride grow Sponsorship for 2017! Please copy the image URL to share on social media.
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Biogen: www.biogen.com/
DPR Construction: www.dpr.com/
Onslow Memorial Hospital: www.onslow.org/
CarolinaEast Medical Center: www.carolinaeasthealth.com/
Precision Race: www.precisionrace.com/
Carolina Brewing Company: www.carolinabrew.com/
Raleigh Neurology: www.raleighneurology.com/
Bike MS: secure.nationalmssociety.org/site/SPageNavigator/BIKE_HOM...
National Multiple Sclerosis Society:http://www.nationalmssociety.org/
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Help BikeMS New Bern Ride grow Sponsorship for 2017! Please copy the image URL to share on social media.
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Biogen: www.biogen.com/
DPR Construction: www.dpr.com/
Onslow Memorial Hospital: www.onslow.org/
CarolinaEast Medical Center: www.carolinaeasthealth.com/
Precision Race: www.precisionrace.com/
Carolina Brewing Company: www.carolinabrew.com/
Raleigh Neurology: www.raleighneurology.com/
Bike MS: secure.nationalmssociety.org/site/SPageNavigator/BIKE_HOM...
National Multiple Sclerosis Society:http://www.nationalmssociety.org/
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The Clinical Neurolgy panel: Anke Hensiek, William Whitehouse, Michèl Willemsen, Tom Crawford and Kate Sinclair
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CarolinaEast Medical Center: www.carolinaeasthealth.com/
Precision Race: www.precisionrace.com/
Carolina Brewing Company: www.carolinabrew.com/
Raleigh Neurology: www.raleighneurology.com/
Bike MS: secure.nationalmssociety.org/site/SPageNavigator/BIKE_HOM...
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In the event that you have lost a loved one because of neurology malpractice, you should be aware that you may be able to file a wrongful death claim on behalf of the decedent.
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Precision Race: www.precisionrace.com/
Carolina Brewing Company: www.carolinabrew.com/
Raleigh Neurology: www.raleighneurology.com/
Bike MS: secure.nationalmssociety.org/site/SPageNavigator/BIKE_HOM...
National Multiple Sclerosis Society:http://www.nationalmssociety.org/
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We are among the Best Neurologist in Jaipur. Best Neurology Hospital in Jaipur offers the best Neurological treatment services in Jaipur. Our team at Barala Hospital, under the guidance of Dr. Amit Barala, is able to provide most comprehensive treatment to the patients. The neurologists are the medical experts who specialize in neurology and are involved in the study of the nervous system of a human.
MedGlobal Volunteer Neurologist provides education during teaching rounds on the Neurology service at Nasser Hospital in the Gaza Strip.
Laboratorio di Biofilm Microbici della Fondazione Santa Lucia. Diretto dal Prof. Gianfranco Donelli.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.
www.medpagetoday.com/neurology/longcovid/102384
Autopsies Show COVID-19 in the Brain
What this means for neurologic COVID symptoms remains elusive
Early this year, leading researchers discussed what we knew -- and didn't know -- about COVID-19 and the brainopens in a new tab or window. Since then, new findings have emerged about SARS-CoV-2 and the nervous system, including the results of an autopsy study that showed the presence of the virus throughout the body and brain.
How can a respiratory pathogen like SARS-CoV-2 cause the nervous system to go haywire? That's the question researchers posed in January, and it's still being asked nearly a year later.
Neurologic complications of COVID are diverse and can be long-lasting, noted Avindra Nath, MD, of the National Institute of Neurological Disorders and Stroke, at the time. "They are largely immune-mediated, the brain endothelial cells being a major target," he told MedPage Today.
Research throughout the year supported this view. In July, an autopsy study of nine COVID patientsopens in a new tab or window showed vascular damage with serum proteins leaking into the brain parenchyma, accompanied by widespread endothelial cell activation. Consistent with other studiesopens in a new tab or window, SARS-CoV-2 virus was not detected in the brain.
But in December, an autopsy report of 44 peopleopens in a new tab or window who died with COVID-19 in the first year of the pandemic showed that SARS-CoV-2 virus had spread throughout the body -- including the brain -- and persisted in tissue for months.
Despite this, there was little evidence of inflammation or direct viral cytopathology outside the respiratory tract, reported Daniel Chertow, MD, MPH, of the NIH Clinical Center and the National Institute of Allergy and Infectious Diseases, and co-authors in Nature.
"We did a total of 44 autopsies and in 11 of those, we were able to do a detailed evaluation of the brain," Chertow told MedPage Today. "In most of those individuals where we had brain [samples], we did find evidence of viral RNA and protein across multiple regions we sampled."
"And in one of those patients, using a modified Vero cell line that expresses the human ACE2 and TMPRSS2 receptors, we actually were able to culture virus from the brain," he continued. "So we were able to show not just the presence of viral components -- RNA and protein -- but also live, replication-competent virus."
Several factors set this autopsy study apart from others, Chertow pointed out. The postmortem interval was short, a median of 22 hours, he said.
"In addition, at the time of autopsy, we freshly dissected brain tissue," he added. "We collected tissue from 10 different regions of the brain, and from each of those regions, we preserved tissues in different ways that were amenable for the types of downstream analyses we did."
The findings may not be generalizable, Chertow cautioned. "Everybody in our cohort was unvaccinated because the study was done during the first year of the pandemic, before the vaccine was available," he said. "And most of the people were older and had significant comorbidities." The cohort included predominantly severe and ultimately fatal COVID cases, and results might not apply to younger, healthier, or vaccinated individuals.
Despite its limitations, the study showed that SARS-CoV-2 has the potential to disseminate to cells and tissues throughout the body and the brain, though it leaves important questions unanswered.
"This is a meticulously done detailed study showing that SARS-CoV-2 infection is indeed systemic and involves many organ systems, including the brain," observed Ziyad Al-Aly, MD, of Washington University in St. Louis, who wasn't involved with the research.
"What the study doesn't show is the presence of inflammation, cytopathology, or a clear mechanistic explanation of the neurologic complications of SARS-CoV-2 infection," Al-Aly told MedPage Today.
"Much more needs to be done to help us understand the mechanisms underpinning the neurologic injury we see so vividly in people with COVID-19 both in the acute and the long COVID phase of the disease," he added.
Also contributing to the knowledge of COVID and the brain in 2022 was the case report of a 27-year-old epilepsy surgery patientopens in a new tab or window who recovered from COVID without respiratory compromise.
Extracellular vesicles isolated from her brain biopsy tissue showed the presence of viral nucleocapsid protein, which was associated with endothelial cell activation, fibrinogen leakage, and immune cell infiltration, reported Nath and co-authors in Neurology.
"We never found the virus," Nath told MedPage Today. "We found the viral protein, but no RNA."
Few researchers have found the virus, Nath noted. And when they do find it, "it's not like they're finding overwhelming amounts of virus in the brain," he pointed out. "They find very small amounts of it."
"The question is, really, how significant is it?" he added. "Is it driving the pathology or is it just sitting there? That still remains to be understood."
Laboratorio di Neurobiofisica della Fondazione Santa Lucia. Diretto dalla Dott.ssa Cristina Zona.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.
The mist covers the forest reminding me the haunting stories my elders use to tell me when i was young. Just like a fairy tale.
Laboratorio per lo Studio delle Atassie della Fondazione Santa Lucia. Diretto dal Prof.ssa Maria Leggio.
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Help BikeMS New Bern Ride grow Sponsorship for 2017! Please copy the image URL to share on social media.
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Biogen: www.biogen.com/
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Onslow Memorial Hospital: www.onslow.org/
CarolinaEast Medical Center: www.carolinaeasthealth.com/
Precision Race: www.precisionrace.com/
Carolina Brewing Company: www.carolinabrew.com/
Raleigh Neurology: www.raleighneurology.com/
Bike MS: secure.nationalmssociety.org/site/SPageNavigator/BIKE_HOM...
National Multiple Sclerosis Society:http://www.nationalmssociety.org/
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Laboratorio di Neurobiofisica della Fondazione Santa Lucia. Diretto dalla Dott.ssa Cristina Zona.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.
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Laboratorio di Biofilm Microbici della Fondazione Santa Lucia. Diretto dal Prof. Gianfranco Donelli.
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Taitin Hamilton already speaks Spanish, is learning French and aims for a total of six spoken languages. He graduated high school at 16 and has a knack for academics. Taitin Hamilton is also passionate about extreme sports such as snowboarding, skydiving, and rock climbing. He is a licensed skydiver.
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The best neuro hospitals in Jaipur treating disorders related to nervous system. The best top neurology hospitals care for the brain and spinal cord in the central nervous system. Also, neuro hospitals in Jaipur address issues with the peripheral nervous system which include eyes, skin, ears and other sensory receptors. Doctors at Neurology Hospital in Jaipur treat disorders affecting the brain, neurological disorders such as headaches, brain infections etc.
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#WorldStrokeDay 2018
Suffering a #stroke can cause many significant and challenging mental and physical changes; but, continuing to work toward recovery is important.
Finding your new normal after a stroke won’t happen all at once—and that’s OK. Developing a new routine and tracking small, step-by-step goals will help.
Your medical team is there to help. Keep them informed of progress, concerns and changes to how you can support your own therapy.
UCSF Neurology. Stephen Hauser greeted me at the Weill Institute for Neurosciences at UCSF with the kind of presence that immediately quiets a room, not through authority, but warmth. There’s something patient and steady in his demeanor. The kind of person who, even after decades at the front lines of medicine, still makes you feel like he’s right there with you, fully. No distance. No armor.
Hauser is best known for transforming our understanding and treatment of multiple sclerosis. For much of the twentieth century, MS remained a stubborn mystery. The prevailing theories focused on T cells. But Hauser, drawing from both intuition and evidence, kept coming back to the role of B cells. It was an unpopular view for years. He persisted.
That persistence changed the world. Through careful experiments and dogged collaboration with immunologists and neurologists across continents, Hauser and his team developed a B cell-targeted therapy that dramatically altered the course of the disease. What had been a cruel and unpredictable spiral for patients became something that could be slowed, managed, even arrested. The treatment, now used around the globe, is one of the clearest examples in modern medicine of science reshaping fate. Millions of people are living freer lives because he stayed the course.
But that isn’t the whole story. In person, Hauser radiates kindness. He listens more than he speaks. He remembers small things and follows up. During our visit, he was quick to credit his colleagues and trainees. There is no trace of the solitary genius trope. Instead, you get the sense of a man who believes deeply in teams, in shared discovery, in lifting others.
He writes about this beautifully in his memoir, The Face Laughs While the Brain Cries. It’s an honest, often poetic look at his life in medicine—his own early fears, the patients who shaped him, the losses, the breakthroughs. The title comes from a moment that only a neurologist might recognize: the face of a patient with a certain kind of brain injury, smiling mechanically while the person inside weeps. That kind of dissonance, between surface and soul, is something Hauser has spent a lifetime trying to bridge.
There is something sacred about the work he does. Not in a lofty, abstract sense, but in the way he remains present with patients. The way he speaks about them, decades after seeing them last. The way he still seems a little awed by biology itself.
As we wrapped our session, I asked him what still drives him. He paused for a long moment before answering. Then he said, “Because it’s not finished. There is still more we don’t understand than we do.” He smiled. “And I still believe we can help.”
That, in the end, might be the most remarkable thing about Stephen Hauser. Not just what he’s accomplished, but that after all this time, he still walks forward with wonder.
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World’s largest rehabilitation research event: ACRM Annual Conference 2019 CHICAGO :: Progress in Rehabilitation Research :: Translation to Clinical Practice :: ACRMconference.org
Laboratorio di Biofilm Microbici della Fondazione Santa Lucia. Diretto dal Prof. Gianfranco Donelli.
DIRITTI DI UTILIZZO: gratuitamente su ogni tipo di supporto a soli scopi d'informazione relativi alla Fondazione Santa Lucia IRCCS. Per chiedere autorizzazione ad altri usi, scrivi a: ufficio.stampa@hsantalucia.it.